IZUMO1R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative thymic T cell selection (GO:0045060)8.65963614
2negative T cell selection (GO:0043383)8.46648085
3positive thymic T cell selection (GO:0045059)7.83508312
4positive regulation of gamma-delta T cell activation (GO:0046645)7.54468713
5regulation of isotype switching to IgG isotypes (GO:0048302)7.52582393
6thymic T cell selection (GO:0045061)7.39473424
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.27049237
8regulation of T cell tolerance induction (GO:0002664)7.26950157
9leukocyte aggregation (GO:0070486)7.13178484
10positive T cell selection (GO:0043368)6.73124886
11T cell selection (GO:0045058)6.59666861
12tolerance induction (GO:0002507)6.52083965
13cellular response to interleukin-15 (GO:0071350)6.40117120
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.31187644
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.27149337
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.27149337
17response to interleukin-15 (GO:0070672)6.16833910
18lymphocyte costimulation (GO:0031294)6.08703767
19T cell costimulation (GO:0031295)6.08489615
20T cell receptor signaling pathway (GO:0050852)5.97419637
21regulation of gamma-delta T cell differentiation (GO:0045586)5.97062343
22positive regulation of tolerance induction (GO:0002645)5.93785469
23regulation of gamma-delta T cell activation (GO:0046643)5.58161205
24T cell migration (GO:0072678)5.53272402
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44942678
26sequestering of actin monomers (GO:0042989)5.41986121
27antigen processing and presentation of endogenous antigen (GO:0019883)5.21329865
28negative regulation of cell killing (GO:0031342)5.19953868
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.19953868
30regulation of tolerance induction (GO:0002643)5.17102407
31regulation of interleukin-2 biosynthetic process (GO:0045076)4.97850056
32antigen receptor-mediated signaling pathway (GO:0050851)4.91225287
33regulation of alpha-beta T cell proliferation (GO:0046640)4.86148245
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.83733487
35positive regulation of alpha-beta T cell proliferation (GO:0046641)4.77187325
36regulation of T cell receptor signaling pathway (GO:0050856)4.64630216
37interferon-gamma production (GO:0032609)4.49904304
38regulation of regulatory T cell differentiation (GO:0045589)4.48886739
39regulation of B cell receptor signaling pathway (GO:0050855)4.37953493
40regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.37935346
41regulation of isotype switching (GO:0045191)4.34010835
42regulation of type I interferon-mediated signaling pathway (GO:0060338)4.24332648
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.21125743
44regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.13007783
45regulation of response to interferon-gamma (GO:0060330)4.12093093
46positive regulation of interleukin-2 production (GO:0032743)4.07454121
47response to type I interferon (GO:0034340)4.02346683
48cellular response to type I interferon (GO:0071357)4.01629194
49type I interferon signaling pathway (GO:0060337)4.01629194
50regulation of immunoglobulin mediated immune response (GO:0002889)3.94624820
51positive regulation of humoral immune response (GO:0002922)3.88214913
52antigen processing and presentation via MHC class Ib (GO:0002475)3.87674771
53regulation of B cell mediated immunity (GO:0002712)3.80532635
54regulation of immunoglobulin production (GO:0002637)3.77911372
55mast cell activation (GO:0045576)3.74989538
56regulation of defense response to virus by virus (GO:0050690)3.74724958
57positive regulation of natural killer cell mediated immunity (GO:0002717)3.73889347
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.73889347
59positive regulation of lamellipodium assembly (GO:0010592)3.73802990
60positive regulation of interleukin-4 production (GO:0032753)3.70577060
61regulation of interleukin-4 production (GO:0032673)3.64329635
62regulation of natural killer cell mediated immunity (GO:0002715)3.63948293
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.63948293
64tumor necrosis factor-mediated signaling pathway (GO:0033209)3.62708998
65positive regulation of isotype switching (GO:0045830)3.61887231
66negative regulation of B cell mediated immunity (GO:0002713)3.57220506
67negative regulation of immunoglobulin mediated immune response (GO:0002890)3.57220506
68negative regulation of type 2 immune response (GO:0002829)3.52700815
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.52188638
70positive regulation of B cell mediated immunity (GO:0002714)3.49634647
71positive regulation of immunoglobulin mediated immune response (GO:0002891)3.49634647
72cellular response to interferon-beta (GO:0035458)3.46743743
73leukocyte cell-cell adhesion (GO:0007159)3.45892820
74negative regulation of T cell mediated immunity (GO:0002710)3.44164041
75regulation of respiratory burst (GO:0060263)3.41499964
76T cell differentiation (GO:0030217)3.41412367
77positive regulation of T cell activation (GO:0050870)3.34336574
78immune response-activating cell surface receptor signaling pathway (GO:0002429)3.34084447
79NIK/NF-kappaB signaling (GO:0038061)3.33473592
80T cell activation (GO:0042110)3.26794055
81negative regulation of lymphocyte mediated immunity (GO:0002707)3.26758069
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.26356120
83interferon-gamma-mediated signaling pathway (GO:0060333)3.23641026
84positive regulation of calcium-mediated signaling (GO:0050850)3.19931497
85positive regulation of lamellipodium organization (GO:1902745)3.19733130
86T cell homeostasis (GO:0043029)3.17554685
87regulation of leukocyte mediated cytotoxicity (GO:0001910)3.15493579
88regulation of interleukin-2 production (GO:0032663)3.11538294
89regulation of immunoglobulin secretion (GO:0051023)3.11391598
90positive regulation of DNA recombination (GO:0045911)3.09433377
91negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.08247377
92positive regulation of T cell differentiation in thymus (GO:0033089)3.05811743
93negative regulation of T cell receptor signaling pathway (GO:0050860)3.05018163
94alpha-beta T cell differentiation (GO:0046632)3.04396626
95natural killer cell activation (GO:0030101)3.03876108
96regulation of T cell activation (GO:0050863)3.03749633
97positive regulation of immunoglobulin production (GO:0002639)3.02713848
98regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.97453712
99alpha-beta T cell activation (GO:0046631)2.97435127
100positive regulation of macrophage differentiation (GO:0045651)2.96823252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.88726667
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.12956340
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.83820402
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.70902902
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.45356460
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.10499907
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.83654502
8RUNX_20019798_ChIP-Seq_JUKART_Human3.68206605
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.41068779
10MYB_26560356_Chip-Seq_TH2_Human3.37328142
11MYC_22102868_ChIP-Seq_BL_Human3.20009175
12MAF_26560356_Chip-Seq_TH1_Human3.06932652
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.01490025
14UTX_26944678_Chip-Seq_JUKART_Human2.90474244
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82686778
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.78022923
17MYB_26560356_Chip-Seq_TH1_Human2.75377771
18MAF_26560356_Chip-Seq_TH2_Human2.35059292
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32723204
20E2F7_22180533_ChIP-Seq_HELA_Human2.28397490
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22055665
22GATA3_27048872_Chip-Seq_THYMUS_Human2.17368825
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.13017990
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.09631106
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.00748941
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90730721
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87726751
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87315873
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.84222372
30SPI1_23547873_ChIP-Seq_NB4_Human1.80997684
31VDR_21846776_ChIP-Seq_THP-1_Human1.80490432
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72725437
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68426772
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61113869
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53036472
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51332427
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46624981
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46556373
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40967123
40GATA3_26560356_Chip-Seq_TH2_Human1.38471979
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37719220
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37472051
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.36329196
44VDR_24763502_ChIP-Seq_THP-1_Human1.35968129
45TCF7_22412390_ChIP-Seq_EML_Mouse1.34952457
46KDM2B_26808549_Chip-Seq_DND41_Human1.32454825
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32234956
48VDR_23849224_ChIP-Seq_CD4+_Human1.29659432
49SPI1_23127762_ChIP-Seq_K562_Human1.29317988
50FOXP3_21729870_ChIP-Seq_TREG_Human1.28031552
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27326597
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23666674
53CIITA_25753668_ChIP-Seq_RAJI_Human1.22852700
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19092386
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18025090
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17428836
57SCL_19346495_ChIP-Seq_HPC-7_Human1.17204310
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16156984
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14624863
60PU_27001747_Chip-Seq_BMDM_Mouse1.14605780
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07407975
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07229976
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06954990
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04559132
65GABP_17652178_ChIP-ChIP_JURKAT_Human1.01740594
66KDM2B_26808549_Chip-Seq_JURKAT_Human0.97281601
67EGR1_19374776_ChIP-ChIP_THP-1_Human0.96251860
68FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92541601
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91442987
70FLI1_27457419_Chip-Seq_LIVER_Mouse0.90669779
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90491770
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90220408
73KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88768187
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88117194
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87909059
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85528132
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84906817
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84740136
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84277415
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83531096
81ELK3_25401928_ChIP-Seq_HUVEC_Human0.82199399
82E2F4_17652178_ChIP-ChIP_JURKAT_Human0.78115322
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76862922
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74908161
85CTCF_26484167_Chip-Seq_Bcells_Mouse0.74565059
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73819238
87RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73731881
88EST1_17652178_ChIP-ChIP_JURKAT_Human0.73583853
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.71436847
90SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.70065683
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69963865
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.68663827
93FLI1_21867929_ChIP-Seq_CD8_Mouse0.68122670
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68027721
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.67697353
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67116126
97BCL6_27268052_Chip-Seq_Bcells_Human0.67005712
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66915098
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.66130920
100ELK1_19687146_ChIP-ChIP_HELA_Human0.65533069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.23336902
2MP0005671_abnormal_response_to5.19287527
3MP0000685_abnormal_immune_system3.74547275
4MP0001835_abnormal_antigen_presentation3.72717097
5MP0002166_altered_tumor_susceptibility3.62019026
6MP0001800_abnormal_humoral_immune3.21276305
7MP0006082_CNS_inflammation3.07979782
8MP0002006_tumorigenesis3.07942464
9MP0005000_abnormal_immune_tolerance3.06347239
10MP0009333_abnormal_splenocyte_physiolog3.01839624
11MP0005387_immune_system_phenotype2.97302285
12MP0001790_abnormal_immune_system2.97302285
13MP0009785_altered_susceptibility_to2.91718143
14MP0002420_abnormal_adaptive_immunity2.89456625
15MP0002723_abnormal_immune_serum2.87530712
16MP0002398_abnormal_bone_marrow2.86944144
17MP0001819_abnormal_immune_cell2.86262326
18MP0003724_increased_susceptibility_to2.72421855
19MP0005025_abnormal_response_to2.64974740
20MP0000703_abnormal_thymus_morphology2.58473302
21MP0002452_abnormal_antigen_presenting2.55845587
22MP0002405_respiratory_system_inflammati2.50450703
23MP0000716_abnormal_immune_system2.50376950
24MP0002933_joint_inflammation2.36568041
25MP0002722_abnormal_immune_system2.33368679
26MP0004947_skin_inflammation2.33275423
27MP0001873_stomach_inflammation2.30293807
28MP0003866_abnormal_defecation2.26253617
29MP0000689_abnormal_spleen_morphology2.25883443
30MP0010155_abnormal_intestine_physiology2.16452420
31MP0002396_abnormal_hematopoietic_system2.10726506
32MP0002429_abnormal_blood_cell1.98576258
33MP0004510_myositis1.95893192
34MP0003436_decreased_susceptibility_to1.92394579
35MP0005310_abnormal_salivary_gland1.87082636
36MP0003300_gastrointestinal_ulcer1.76657530
37MP0002419_abnormal_innate_immunity1.69891053
38MP0001845_abnormal_inflammatory_respons1.65400691
39MP0002148_abnormal_hypersensitivity_rea1.62123718
40MP0001853_heart_inflammation1.55786232
41MP0000858_altered_metastatic_potential1.43489518
42MP0001851_eye_inflammation1.41382371
43MP0004381_abnormal_hair_follicle1.34443063
44MP0005464_abnormal_platelet_physiology1.28880638
45MP0008469_abnormal_protein_level1.23316904
46MP0003448_altered_tumor_morphology1.16252363
47MP0005451_abnormal_body_composition1.14917000
48MP0002019_abnormal_tumor_incidence1.08183712
49MP0005023_abnormal_wound_healing1.06445522
50MP0001348_abnormal_lacrimal_gland1.03353386
51MP0000465_gastrointestinal_hemorrhage1.02012400
52MP0000490_abnormal_crypts_of0.98424040
53MP0003303_peritoneal_inflammation0.96884338
54MP0003077_abnormal_cell_cycle0.94899246
55MP0002822_catalepsy0.94881468
56MP0001533_abnormal_skeleton_physiology0.94174442
57MP0003045_fibrosis0.89276583
58MP0004808_abnormal_hematopoietic_stem0.88242835
59MP0000604_amyloidosis0.87972529
60MP0009763_increased_sensitivity_to0.85543726
61MP0002998_abnormal_bone_remodeling0.82235439
62MP0003329_amyloid_beta_deposits0.81021020
63MP0003787_abnormal_imprinting0.78726875
64MP0008057_abnormal_DNA_replication0.73566001
65MP0009765_abnormal_xenobiotic_induced0.70922015
66MP0002009_preneoplasia0.69561060
67MP0009764_decreased_sensitivity_to0.69103724
68MP0000477_abnormal_intestine_morphology0.68702208
69MP0008877_abnormal_DNA_methylation0.68067616
70MP0010352_gastrointestinal_tract_polyps0.66730417
71MP0005075_abnormal_melanosome_morpholog0.63537236
72MP0003795_abnormal_bone_structure0.60607159
73MP0002693_abnormal_pancreas_physiology0.59736211
74MP0008569_lethality_at_weaning0.56632390
75MP0010234_abnormal_vibrissa_follicle0.56624898
76MP0000343_altered_response_to0.55637817
77MP0002163_abnormal_gland_morphology0.53980183
78MP0010094_abnormal_chromosome_stability0.53081651
79MP0003221_abnormal_cardiomyocyte_apopto0.51973568
80MP0003453_abnormal_keratinocyte_physiol0.51835088
81MP0004957_abnormal_blastocyst_morpholog0.49026869
82MP0001216_abnormal_epidermal_layer0.48910584
83MP0003693_abnormal_embryo_hatching0.48551647
84MP0003111_abnormal_nucleus_morphology0.47391695
85MP0000609_abnormal_liver_physiology0.47262359
86MP0001191_abnormal_skin_condition0.47246327
87MP0002909_abnormal_adrenal_gland0.46561952
88MP0001545_abnormal_hematopoietic_system0.46187654
89MP0005397_hematopoietic_system_phenotyp0.46187654
90MP0002132_abnormal_respiratory_system0.45903112
91MP0008872_abnormal_physiological_respon0.45669291
92MP0001119_abnormal_female_reproductive0.44015928
93MP0001243_abnormal_dermal_layer0.43487618
94MP0000313_abnormal_cell_death0.43056193
95MP0002138_abnormal_hepatobiliary_system0.42808860
96MP0008007_abnormal_cellular_replicative0.42313786
97MP0002136_abnormal_kidney_physiology0.41308963
98MP0005076_abnormal_cell_differentiation0.40924767
99MP0001663_abnormal_digestive_system0.39329235
100MP0008961_abnormal_basal_metabolism0.35593037

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)6.85493506
2T lymphocytopenia (HP:0005403)6.83483997
3Abnormality of T cell number (HP:0011839)6.72517033
4Recurrent bronchitis (HP:0002837)6.39323147
5Elevated erythrocyte sedimentation rate (HP:0003565)6.36862680
6Combined immunodeficiency (HP:0005387)6.34089064
7IgG deficiency (HP:0004315)6.14761310
8Increased IgM level (HP:0003496)5.90541150
9Abnormality of T cells (HP:0002843)5.72563151
10Stomatitis (HP:0010280)5.69482963
11IgM deficiency (HP:0002850)5.64249204
12Recurrent cutaneous fungal infections (HP:0011370)5.51427097
13Chronic mucocutaneous candidiasis (HP:0002728)5.51427097
14Autoimmune hemolytic anemia (HP:0001890)5.31630764
15B lymphocytopenia (HP:0010976)4.86554375
16Abnormality of B cell number (HP:0010975)4.86554375
17Recurrent fungal infections (HP:0002841)4.81683123
18Eczematoid dermatitis (HP:0000976)4.58736524
19Abnormality of T cell physiology (HP:0011840)4.56650951
20Chronic diarrhea (HP:0002028)4.32529492
21Lymphopenia (HP:0001888)4.27354489
22Panhypogammaglobulinemia (HP:0003139)4.27124280
23Chronic otitis media (HP:0000389)4.24338635
24Pustule (HP:0200039)4.14481893
25IgA deficiency (HP:0002720)4.14358144
26Abnormality of cells of the lymphoid lineage (HP:0012140)4.13595699
27Abnormality of eosinophils (HP:0001879)4.01512577
28Abnormality of the fingertips (HP:0001211)3.82816419
29Myositis (HP:0100614)3.77039453
30Bronchitis (HP:0012387)3.76765727
31Nasal polyposis (HP:0100582)3.76384567
32Recurrent viral infections (HP:0004429)3.74138061
33Thyroiditis (HP:0100646)3.63744811
34Hypoplasia of the thymus (HP:0000778)3.58160086
35Hypergammaglobulinemia (HP:0010702)3.50400952
36Leukocytosis (HP:0001974)3.47139652
37Recurrent sinusitis (HP:0011108)3.45496023
38Joint swelling (HP:0001386)3.42145819
39Eosinophilia (HP:0001880)3.22936579
40Abnormality of the nasal mucosa (HP:0000433)3.13797729
41Recurrent otitis media (HP:0000403)3.03194278
42Reduced subcutaneous adipose tissue (HP:0003758)3.00141412
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.99316608
44Granulocytopenia (HP:0001913)2.96077343
45Hemoptysis (HP:0002105)2.95904415
46Recurrent skin infections (HP:0001581)2.94037560
47Basal cell carcinoma (HP:0002671)2.90598684
48Vasculitis (HP:0002633)2.83228596
49Gastrointestinal infarctions (HP:0005244)2.77295835
50Cheilitis (HP:0100825)2.71619688
51Lymphoma (HP:0002665)2.68324618
52Agammaglobulinemia (HP:0004432)2.66038224
53Retrobulbar optic neuritis (HP:0100654)2.64505475
54Optic neuritis (HP:0100653)2.64505475
55Thrombocytosis (HP:0001894)2.52995448
56Recurrent abscess formation (HP:0002722)2.45264270
57Gastrointestinal stroma tumor (HP:0100723)2.41668523
58Meningitis (HP:0001287)2.41294044
59Pulmonary infiltrates (HP:0002113)2.39184950
60Poikiloderma (HP:0001029)2.32337170
61Emphysema (HP:0002097)2.29108822
62Obstructive lung disease (HP:0006536)2.26809208
63Chronic obstructive pulmonary disease (HP:0006510)2.26809208
64Mediastinal lymphadenopathy (HP:0100721)2.24962864
65Increased density of long bones (HP:0006392)2.21968734
66Orchitis (HP:0100796)2.20654311
67Autoimmune thrombocytopenia (HP:0001973)2.20287641
68Encephalitis (HP:0002383)2.17829427
69Bronchiectasis (HP:0002110)2.15052978
70Hepatitis (HP:0012115)2.12741189
71Amyotrophic lateral sclerosis (HP:0007354)2.10736231
72Chronic sinusitis (HP:0011109)2.08066305
73Entropion (HP:0000621)2.04350161
74Abnormality of the endocardium (HP:0004306)2.04268251
75Abnormality of the prostate (HP:0008775)1.99265721
76Keratoconjunctivitis sicca (HP:0001097)1.97846514
77Gingivitis (HP:0000230)1.93185472
78Seborrheic dermatitis (HP:0001051)1.92951396
79Pulmonary fibrosis (HP:0002206)1.86733547
80Skin rash (HP:0000988)1.86186404
81Microcytic anemia (HP:0001935)1.84689126
82Papilloma (HP:0012740)1.83267966
83Verrucae (HP:0200043)1.83267966
84Gangrene (HP:0100758)1.79810850
85Increased IgE level (HP:0003212)1.77101017
86Arthralgia (HP:0002829)1.76540000
87Keratoconjunctivitis (HP:0001096)1.76495173
88Skin ulcer (HP:0200042)1.75692937
89Ureteral stenosis (HP:0000071)1.75021895
90Aplasia/Hypoplasia of the thymus (HP:0010515)1.73787886
91Inflammation of the large intestine (HP:0002037)1.71102237
92Gastrointestinal inflammation (HP:0004386)1.71088442
93Neutropenia (HP:0001875)1.66593418
94Spontaneous hematomas (HP:0007420)1.65827657
95Abnormality of DNA repair (HP:0003254)1.64536340
96Basal ganglia calcification (HP:0002135)1.63946892
97Anorexia (HP:0002039)1.63599261
98Large eyes (HP:0001090)1.62908664
99Pulmonary embolism (HP:0002204)1.60129671
100Polyneuropathy (HP:0001271)1.60033254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.50985852
2MAP4K15.43836175
3FGFR45.18544631
4IKBKE3.87712213
5ZAP703.64589523
6JAK33.57138907
7TYK23.40544531
8FGFR32.69968951
9KDR2.66535381
10TESK22.52295969
11ITK2.43230483
12MAP3K122.37458891
13JAK12.23841039
14STK102.15966436
15TBK12.13462040
16KIT2.10863783
17LCK2.10501200
18BLK1.80645704
19NLK1.64305909
20MAP3K141.49733143
21GRK61.42800456
22TEC1.31355166
23SYK1.27720833
24PRKCH1.27461249
25MAP3K131.24337549
26HCK1.21372760
27CSK1.20423827
28NME21.16192920
29EEF2K1.13012003
30PRKCQ1.06069165
31MAPK110.92511099
32BTK0.88192576
33LRRK20.88015796
34JAK20.86517889
35TESK10.84704601
36LYN0.81936798
37TYRO30.77375291
38MARK30.72459350
39TAOK10.71597400
40IKBKB0.69116291
41IRAK40.64132483
42SIK30.62894822
43MARK20.57959496
44MAP2K60.57808171
45SIK20.55462213
46CLK10.55021615
47FGFR10.54303956
48ILK0.52253127
49FYN0.51903856
50MYLK0.49825095
51TNK20.48502180
52MST40.47968910
53CHUK0.46878703
54NTRK20.46756147
55EPHA30.45796126
56TLK10.44695335
57INSR0.43722049
58CSF1R0.43566540
59RPS6KA40.42500086
60IGF1R0.41707021
61PDGFRB0.41612093
62FGFR20.41061623
63PDK10.40402078
64FES0.38903256
65PRKD20.38234941
66LIMK10.37348782
67MAP3K70.35831229
68RPS6KA50.34829316
69MAP3K100.34559398
70PIM10.33678374
71EIF2AK10.33317828
72TAOK30.33277847
73CDC70.32403027
74CSNK1A1L0.31700157
75PASK0.30240694
76TGFBR20.26688653
77CSNK1G10.26387025
78BUB10.26248823
79RAF10.25769935
80CSNK1G30.25718194
81TGFBR10.23771375
82DMPK0.22460098
83HIPK20.22281511
84MELK0.20280375
85MAPK30.20196118
86EGFR0.19788720
87CDK40.19730233
88ABL10.18585312
89SIK10.16178628
90IRAK10.15901596
91ACVR1B0.15805416
92PRKCD0.14293838
93SRC0.13109815
94SRPK10.13064194
95DAPK10.12765553
96ALK0.12550371
97ROCK20.11688438
98DAPK30.11516114
99BRD40.11483303
100MAP3K80.09323809

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.27011398
2T cell receptor signaling pathway_Homo sapiens_hsa046604.32214472
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.25252386
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.20151922
5Measles_Homo sapiens_hsa051623.16766250
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.12367242
7Allograft rejection_Homo sapiens_hsa053302.90671504
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.54229713
9Viral myocarditis_Homo sapiens_hsa054162.42859017
10Autoimmune thyroid disease_Homo sapiens_hsa053202.41990185
11Hematopoietic cell lineage_Homo sapiens_hsa046402.33198699
12Antigen processing and presentation_Homo sapiens_hsa046122.10073357
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86457466
14Leishmaniasis_Homo sapiens_hsa051401.75963812
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74978122
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72256502
17Herpes simplex infection_Homo sapiens_hsa051681.71695225
18Graft-versus-host disease_Homo sapiens_hsa053321.68771315
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.66817041
20Asthma_Homo sapiens_hsa053101.60049369
21Osteoclast differentiation_Homo sapiens_hsa043801.57362246
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53879851
23Pancreatic cancer_Homo sapiens_hsa052121.35345423
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32033992
25Hepatitis B_Homo sapiens_hsa051611.29086633
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28794852
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24664554
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22386410
29Shigellosis_Homo sapiens_hsa051311.20848117
30Toxoplasmosis_Homo sapiens_hsa051451.20451220
31Chemokine signaling pathway_Homo sapiens_hsa040621.19339225
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.13446549
33B cell receptor signaling pathway_Homo sapiens_hsa046621.12330962
34Ribosome_Homo sapiens_hsa030101.10081117
35HTLV-I infection_Homo sapiens_hsa051661.09665558
36Caffeine metabolism_Homo sapiens_hsa002321.01495970
37Influenza A_Homo sapiens_hsa051640.95612601
38Prolactin signaling pathway_Homo sapiens_hsa049170.91496334
39Hepatitis C_Homo sapiens_hsa051600.90028834
40Proteasome_Homo sapiens_hsa030500.89248494
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85798017
42Colorectal cancer_Homo sapiens_hsa052100.85105589
43p53 signaling pathway_Homo sapiens_hsa041150.84496355
44Viral carcinogenesis_Homo sapiens_hsa052030.83432606
45Malaria_Homo sapiens_hsa051440.83282216
46RNA degradation_Homo sapiens_hsa030180.82071754
47VEGF signaling pathway_Homo sapiens_hsa043700.81020716
48Apoptosis_Homo sapiens_hsa042100.77138397
49Epstein-Barr virus infection_Homo sapiens_hsa051690.74336719
50Spliceosome_Homo sapiens_hsa030400.72180511
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70538618
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70449101
53Type I diabetes mellitus_Homo sapiens_hsa049400.68261547
54TNF signaling pathway_Homo sapiens_hsa046680.67123988
55Acute myeloid leukemia_Homo sapiens_hsa052210.66025498
56Tuberculosis_Homo sapiens_hsa051520.59636523
57Staphylococcus aureus infection_Homo sapiens_hsa051500.57134014
58Platelet activation_Homo sapiens_hsa046110.56458654
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55402673
60Nucleotide excision repair_Homo sapiens_hsa034200.54383630
61Non-homologous end-joining_Homo sapiens_hsa034500.54027621
62Mismatch repair_Homo sapiens_hsa034300.53732547
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52703597
64Basal transcription factors_Homo sapiens_hsa030220.51276594
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51006179
66DNA replication_Homo sapiens_hsa030300.50259481
67Legionellosis_Homo sapiens_hsa051340.49687996
68Base excision repair_Homo sapiens_hsa034100.49234610
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46552310
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45356150
71Homologous recombination_Homo sapiens_hsa034400.44205401
72Notch signaling pathway_Homo sapiens_hsa043300.42488884
73Salmonella infection_Homo sapiens_hsa051320.41397231
74Other glycan degradation_Homo sapiens_hsa005110.40873806
75Cell cycle_Homo sapiens_hsa041100.40347954
76Inositol phosphate metabolism_Homo sapiens_hsa005620.36741933
77Endocytosis_Homo sapiens_hsa041440.34793541
78Rap1 signaling pathway_Homo sapiens_hsa040150.33676448
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.32681893
80Chronic myeloid leukemia_Homo sapiens_hsa052200.30972390
81Choline metabolism in cancer_Homo sapiens_hsa052310.30149957
82Rheumatoid arthritis_Homo sapiens_hsa053230.29810635
83mRNA surveillance pathway_Homo sapiens_hsa030150.27565350
84RNA transport_Homo sapiens_hsa030130.26715347
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26240022
86Adherens junction_Homo sapiens_hsa045200.26097552
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24721851
88Pertussis_Homo sapiens_hsa051330.23434783
89Pentose phosphate pathway_Homo sapiens_hsa000300.19946230
90RNA polymerase_Homo sapiens_hsa030200.19002496
91Small cell lung cancer_Homo sapiens_hsa052220.18455597
92MAPK signaling pathway_Homo sapiens_hsa040100.17009301
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16592868
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16090364
95Pathways in cancer_Homo sapiens_hsa052000.15675700
96Ras signaling pathway_Homo sapiens_hsa040140.13660410
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.12102116
98Non-small cell lung cancer_Homo sapiens_hsa052230.11817019
99Pyrimidine metabolism_Homo sapiens_hsa002400.10700333
100FoxO signaling pathway_Homo sapiens_hsa040680.10028269

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