IZUMO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.68225813
2axonemal dynein complex assembly (GO:0070286)9.52709517
3epithelial cilium movement (GO:0003351)9.43385413
4spermatid development (GO:0007286)9.17774151
5single fertilization (GO:0007338)7.77442792
6cilium movement (GO:0003341)7.70293724
7regulation of cilium movement (GO:0003352)7.53089116
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.22718773
9sperm capacitation (GO:0048240)7.12529496
10male meiosis (GO:0007140)6.99868792
11spermatid nucleus differentiation (GO:0007289)6.67544025
12synaptonemal complex organization (GO:0070193)6.62599742
13synaptonemal complex assembly (GO:0007130)6.55786957
14piRNA metabolic process (GO:0034587)6.42232408
15microtubule depolymerization (GO:0007019)6.33995260
16fertilization (GO:0009566)6.28536575
17spermatogenesis (GO:0007283)6.02340601
18male gamete generation (GO:0048232)6.00127622
19negative regulation of inclusion body assembly (GO:0090084)5.97898131
20organic cation transport (GO:0015695)5.91582276
21behavioral response to nicotine (GO:0035095)5.61816233
22gamete generation (GO:0007276)5.52719674
23calcium ion-dependent exocytosis (GO:0017156)5.52407897
24cell recognition (GO:0008037)5.26018513
25regulation of inclusion body assembly (GO:0090083)5.19991054
26response to pheromone (GO:0019236)5.16827058
27cellular process involved in reproduction in multicellular organism (GO:0022412)5.14911854
28L-fucose catabolic process (GO:0042355)5.14280855
29fucose catabolic process (GO:0019317)5.14280855
30L-fucose metabolic process (GO:0042354)5.14280855
31germ cell development (GO:0007281)5.07042658
32ventricular system development (GO:0021591)4.89454814
33glycerol ether metabolic process (GO:0006662)4.60132615
34chromosome organization involved in meiosis (GO:0070192)4.59378789
35sexual reproduction (GO:0019953)4.42311690
36single strand break repair (GO:0000012)4.38835196
37regulation of microtubule-based movement (GO:0060632)4.36777068
38multicellular organismal reproductive process (GO:0048609)4.33701556
39microtubule severing (GO:0051013)4.30640929
40DNA methylation involved in gamete generation (GO:0043046)4.30518514
41ether metabolic process (GO:0018904)4.25171928
42chromosome condensation (GO:0030261)4.21561820
43meiotic nuclear division (GO:0007126)4.16478738
44male meiosis I (GO:0007141)4.14057209
45cellular ketone body metabolic process (GO:0046950)4.13333116
46chaperone-mediated protein complex assembly (GO:0051131)4.02442417
47DNA packaging (GO:0006323)3.91589580
48kynurenine metabolic process (GO:0070189)3.80172651
49DNA deamination (GO:0045006)3.73678232
50ketone body metabolic process (GO:1902224)3.71749330
51tryptophan catabolic process (GO:0006569)3.68724250
52indole-containing compound catabolic process (GO:0042436)3.68724250
53indolalkylamine catabolic process (GO:0046218)3.68724250
54detection of light stimulus involved in sensory perception (GO:0050962)3.68452320
55detection of light stimulus involved in visual perception (GO:0050908)3.68452320
56centriole assembly (GO:0098534)3.63748127
57protein K11-linked deubiquitination (GO:0035871)3.63252516
58indolalkylamine metabolic process (GO:0006586)3.52467359
59monoubiquitinated protein deubiquitination (GO:0035520)3.49616375
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48673687
61multicellular organismal development (GO:0007275)3.47464357
62seminiferous tubule development (GO:0072520)3.47137055
63platelet dense granule organization (GO:0060155)3.45969600
64left/right pattern formation (GO:0060972)3.45399536
65microtubule polymerization or depolymerization (GO:0031109)3.41171542
66protein-cofactor linkage (GO:0018065)3.40071846
67centriole replication (GO:0007099)3.38339743
68protein complex biogenesis (GO:0070271)3.34926081
69negative regulation of telomere maintenance (GO:0032205)3.32017127
70respiratory chain complex IV assembly (GO:0008535)3.29146142
71meiosis I (GO:0007127)3.27656724
72preassembly of GPI anchor in ER membrane (GO:0016254)3.26499273
73kidney morphogenesis (GO:0060993)3.23959049
74tryptophan metabolic process (GO:0006568)3.22358936
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16000347
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.16000347
77NADH dehydrogenase complex assembly (GO:0010257)3.16000347
78mitochondrial respiratory chain complex assembly (GO:0033108)3.14930409
79neural tube formation (GO:0001841)3.11919705
80protein polyglutamylation (GO:0018095)3.11673404
81water-soluble vitamin biosynthetic process (GO:0042364)3.09305550
82positive regulation of macrophage activation (GO:0043032)3.07966517
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02200385
84cytochrome complex assembly (GO:0017004)3.01265065
85genitalia morphogenesis (GO:0035112)3.01081395
86carnitine transport (GO:0015879)2.97929617
87amino-acid betaine transport (GO:0015838)2.97929617
88nucleus organization (GO:0006997)2.96746237
89mannosylation (GO:0097502)2.96679767
90nonmotile primary cilium assembly (GO:0035058)2.96474484
91regulation of spindle checkpoint (GO:0090231)2.94982966
92meiotic cell cycle (GO:0051321)2.90280651
93cornea development in camera-type eye (GO:0061303)2.90087989
94negative regulation of mast cell activation (GO:0033004)2.89237904
95neuronal action potential (GO:0019228)2.88400815
96protein localization to cilium (GO:0061512)2.87798861
97regulation of action potential (GO:0098900)2.87442359
98polyol catabolic process (GO:0046174)2.85015491
99alditol metabolic process (GO:0019400)2.84982190
100carnitine transmembrane transport (GO:1902603)2.81246487
101cilium organization (GO:0044782)2.80842632
102regulation of nuclear cell cycle DNA replication (GO:0033262)2.80549296
103protein refolding (GO:0042026)2.78336913
104synapsis (GO:0007129)2.78239288
105regulation of hexokinase activity (GO:1903299)2.76699411
106regulation of glucokinase activity (GO:0033131)2.76699411
107S-adenosylmethionine metabolic process (GO:0046500)2.75292303
108sequestering of actin monomers (GO:0042989)2.74913961
109glycolytic process (GO:0006096)2.74201230
110nucleoside diphosphate phosphorylation (GO:0006165)2.73829851
111cilium assembly (GO:0042384)2.73071079
112cellular component assembly involved in morphogenesis (GO:0010927)2.71686816
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69587003
114gamma-aminobutyric acid transport (GO:0015812)2.69412792
115tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67666344
116RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67666344
117microtubule-based movement (GO:0007018)2.67069600
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66014145
119indole-containing compound metabolic process (GO:0042430)2.65768441
120ubiquinone biosynthetic process (GO:0006744)2.64926346
121peptidyl-threonine dephosphorylation (GO:0035970)2.64520277
122cilium morphogenesis (GO:0060271)2.63538163
123cellular biogenic amine catabolic process (GO:0042402)2.63415245
124amine catabolic process (GO:0009310)2.63415245
125reciprocal meiotic recombination (GO:0007131)2.63332964
126reciprocal DNA recombination (GO:0035825)2.63332964
127synaptic transmission, cholinergic (GO:0007271)2.63080780
128reflex (GO:0060004)2.63030089
129photoreceptor cell maintenance (GO:0045494)2.62876843
130dopamine transport (GO:0015872)2.62876196
131intraciliary transport (GO:0042073)2.62738846
132somite rostral/caudal axis specification (GO:0032525)2.61436024
133phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61004340
134retinal cone cell development (GO:0046549)2.60011990
135behavioral response to ethanol (GO:0048149)2.59543469
136GTP biosynthetic process (GO:0006183)2.59507629
137meiotic cell cycle process (GO:1903046)2.57605974
138GPI anchor metabolic process (GO:0006505)2.57187689
139replication fork processing (GO:0031297)2.56429350
140nephron tubule morphogenesis (GO:0072078)2.56243446
141nephron epithelium morphogenesis (GO:0072088)2.56243446
142sulfation (GO:0051923)2.55872024
143pyrimidine nucleobase catabolic process (GO:0006208)2.55352604
144single-organism membrane fusion (GO:0044801)2.55310841
145primary amino compound metabolic process (GO:1901160)2.54672651
146regulation of centriole replication (GO:0046599)2.52867816
147ubiquinone metabolic process (GO:0006743)2.52539384
148auditory receptor cell stereocilium organization (GO:0060088)2.51675134
149macroautophagy (GO:0016236)2.51317956
150spinal cord motor neuron differentiation (GO:0021522)2.51042383
151glycerol metabolic process (GO:0006071)2.51016025
152DNA double-strand break processing (GO:0000729)2.49480504
153axoneme assembly (GO:0035082)2.48657763
154adaptation of signaling pathway (GO:0023058)2.46635857
155inositol phosphate catabolic process (GO:0071545)2.46324947
156L-methionine salvage (GO:0071267)2.45777784
157L-methionine biosynthetic process (GO:0071265)2.45777784
158amino acid salvage (GO:0043102)2.45777784
159positive regulation of defense response to virus by host (GO:0002230)2.45543142
160fucosylation (GO:0036065)2.44973702
161RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.42568811
162mitotic sister chromatid cohesion (GO:0007064)2.41792638
163neuronal action potential propagation (GO:0019227)2.41628727
164gene silencing by RNA (GO:0031047)2.41137177
165regulation of mesoderm development (GO:2000380)2.41125389
166chromatin silencing (GO:0006342)2.40901646
167interferon-gamma secretion (GO:0072643)2.39348440
168lactate metabolic process (GO:0006089)2.37576919
169UTP biosynthetic process (GO:0006228)2.32807467
170cell wall macromolecule metabolic process (GO:0044036)17.4208492
171cell wall macromolecule catabolic process (GO:0016998)17.4208492
172fusion of sperm to egg plasma membrane (GO:0007342)15.2108289
173sperm motility (GO:0030317)12.5630957
174multicellular organism reproduction (GO:0032504)12.5192291
175acrosome assembly (GO:0001675)12.2892671
176sperm-egg recognition (GO:0035036)12.0389335
177plasma membrane fusion (GO:0045026)11.5935849
178acrosome reaction (GO:0007340)11.0996390
179cell-cell recognition (GO:0009988)10.7926389
180reproduction (GO:0000003)10.7200931
181cilium or flagellum-dependent cell motility (GO:0001539)10.5151048
182binding of sperm to zona pellucida (GO:0007339)10.2380271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.66446221
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.08587674
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.00900079
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00169108
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79572350
6GBX2_23144817_ChIP-Seq_PC3_Human2.73461266
7EZH2_22144423_ChIP-Seq_EOC_Human2.55405290
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.39026583
9VDR_22108803_ChIP-Seq_LS180_Human2.29086713
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27615199
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25703073
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22899622
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19760918
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.16816185
15FUS_26573619_Chip-Seq_HEK293_Human2.14608273
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13854288
17IGF1R_20145208_ChIP-Seq_DFB_Human2.12483548
18KAP1_22055183_ChIP-Seq_ESCs_Mouse2.10573593
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.10308846
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09888859
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08378433
22EWS_26573619_Chip-Seq_HEK293_Human1.99837935
23ZNF274_21170338_ChIP-Seq_K562_Hela1.97552705
24ER_23166858_ChIP-Seq_MCF-7_Human1.96947323
25TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.96473856
26P300_19829295_ChIP-Seq_ESCs_Human1.96380688
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.93740871
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.91777992
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83023439
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82088216
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.81077012
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.78840945
33GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.78294552
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78237920
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77250780
36KDM2B_26808549_Chip-Seq_REH_Human1.76492925
37IRF1_19129219_ChIP-ChIP_H3396_Human1.73512338
38STAT1_17558387_ChIP-Seq_HELA_Human1.73273789
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.71856869
40MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70792604
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65424154
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.63538164
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62831495
44GATA3_21867929_ChIP-Seq_CD8_Mouse1.62034342
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.61975418
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61023539
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.60284210
48TP53_22573176_ChIP-Seq_HFKS_Human1.58137468
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53799566
50SOX2_22085726_ChIP-Seq_NPCs_Mouse1.53778602
51BCAT_22108803_ChIP-Seq_LS180_Human1.53689566
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53062222
53FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52823796
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52718494
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50238730
56LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.48553589
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48222743
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.47372922
59MYC_18940864_ChIP-ChIP_HL60_Human1.44665143
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.43853248
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42864474
62GATA3_21867929_ChIP-Seq_TH1_Mouse1.41991840
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41562132
64AR_25329375_ChIP-Seq_VCAP_Human1.41295882
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41182814
66STAT3_23295773_ChIP-Seq_U87_Human1.40875255
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39984442
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.39984442
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39586163
70SOX2_19829295_ChIP-Seq_ESCs_Human1.38810627
71NANOG_19829295_ChIP-Seq_ESCs_Human1.38810627
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.38387067
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36476576
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35450422
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34944835
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34540457
77CBP_20019798_ChIP-Seq_JUKART_Human1.34540457
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34539550
79SMAD4_21799915_ChIP-Seq_A2780_Human1.34232312
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34198324
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.32554277
82TCF4_23295773_ChIP-Seq_U87_Human1.32528706
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.31581831
84EST1_17652178_ChIP-ChIP_JURKAT_Human1.31534203
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31443831
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31188256
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30964291
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30653914
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.30473040
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.30207719
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.30167696
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29383777
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28738665
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28680342
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27828163
96TCF4_22108803_ChIP-Seq_LS180_Human1.27610122
97GF1_26923725_Chip-Seq_HPCs_Mouse1.27106672
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22947638
99P300_18555785_Chip-Seq_ESCs_Mouse1.22532250
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22181245
101P53_22387025_ChIP-Seq_ESCs_Mouse1.21558382
102NCOR_22424771_ChIP-Seq_293T_Human1.21536104
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.21368264
104REST_21632747_ChIP-Seq_MESCs_Mouse1.21138053
105RUNX2_22187159_ChIP-Seq_PCA_Human1.21023118
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20782570
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.20513762
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18927203
109P53_21459846_ChIP-Seq_SAOS-2_Human1.18922170
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18491782
111FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18062789
112AR_20517297_ChIP-Seq_VCAP_Human1.17567082
113RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17184000
114ESRRB_18555785_Chip-Seq_ESCs_Mouse1.16605977
115EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16091268
116SPI1_26923725_Chip-Seq_HPCs_Mouse1.15614175
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15560834
118HOXB7_26014856_ChIP-Seq_BT474_Human1.15142167
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.14948783
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13978854
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.11616225
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11472060
123CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11456857
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10695929
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.09898904
126ERA_21632823_ChIP-Seq_H3396_Human1.09454040
127KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09205072
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.08934120
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08929347
130MYC_19829295_ChIP-Seq_ESCs_Human1.08806107
131AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08637547
132NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08287254
133ESET_19884257_ChIP-Seq_ESCs_Mouse1.05716447
134TAF15_26573619_Chip-Seq_HEK293_Human1.05707079
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.05606816
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.04833960
137CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03144303
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.02993314
139RARA_24833708_ChIP-Seq_LIVER_Mouse1.02982802
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02768766
141LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02221799
142VDR_23849224_ChIP-Seq_CD4+_Human1.01939047
143GF1B_26923725_Chip-Seq_HPCs_Mouse1.01777357
144NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.01734386
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01553925
146SOX9_26525672_Chip-Seq_HEART_Mouse1.01484746
147AR_21572438_ChIP-Seq_LNCaP_Human1.01099725
148RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00754831
149RNF2_27304074_Chip-Seq_NSC_Mouse1.00708554
150NANOG_20526341_ChIP-Seq_ESCs_Human1.00524760
151SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99448264
152FOXH1_21741376_ChIP-Seq_EPCs_Human0.99381627
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99343703
154PU1_27457419_Chip-Seq_LIVER_Mouse0.99129032
155RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98478138
156TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97970181
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97970181
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.97937171
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97907889
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97657246
161TAF2_19829295_ChIP-Seq_ESCs_Human0.97631290
162STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97187847
163FLI1_21867929_ChIP-Seq_CD8_Mouse0.96744499
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96563103
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96441906
166REST_18959480_ChIP-ChIP_MESCs_Mouse0.94931208
167GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94526033
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94350161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11627360
2MP0001929_abnormal_gametogenesis5.57301490
3MP0008877_abnormal_DNA_methylation4.30935414
4MP0002210_abnormal_sex_determination3.54253774
5MP0002161_abnormal_fertility/fecundity3.31765727
6MP0002653_abnormal_ependyma_morphology3.31026483
7MP0001145_abnormal_male_reproductive3.02006597
8MP0003195_calcinosis2.90231027
9MP0005670_abnormal_white_adipose2.78722987
10MP0000653_abnormal_sex_gland2.64498928
11MP0000569_abnormal_digit_pigmentation2.45095588
12MP0001986_abnormal_taste_sensitivity2.26215818
13MP0004233_abnormal_muscle_weight2.08355725
14MP0006072_abnormal_retinal_apoptosis2.07976197
15MP0002876_abnormal_thyroid_physiology2.07453603
16MP0005645_abnormal_hypothalamus_physiol2.07369427
17MP0003787_abnormal_imprinting2.04863892
18MP0005410_abnormal_fertilization15.9698878
19MP0003880_abnormal_central_pattern1.97005736
20MP0009745_abnormal_behavioral_response1.95109887
21MP0004147_increased_porphyrin_level1.94354043
22MP0002837_dystrophic_cardiac_calcinosis1.88828515
23MP0004885_abnormal_endolymph1.86174218
24MP0005623_abnormal_meninges_morphology1.81207255
25MP0006292_abnormal_olfactory_placode1.78221020
26MP0001501_abnormal_sleep_pattern1.74303081
27MP0002272_abnormal_nervous_system1.69709383
28MP0003136_yellow_coat_color1.68468729
29MP0000372_irregular_coat_pigmentation1.68129494
30MP0002638_abnormal_pupillary_reflex1.67187098
31MP0004142_abnormal_muscle_tone1.63835333
32MP0000427_abnormal_hair_cycle1.63792614
33MP0005646_abnormal_pituitary_gland1.63557843
34MP0005084_abnormal_gallbladder_morpholo1.54867398
35MP0001529_abnormal_vocalization1.50490228
36MP0001486_abnormal_startle_reflex1.47469563
37MP0001485_abnormal_pinna_reflex1.43372149
38MP0002938_white_spotting1.43199701
39MP0003283_abnormal_digestive_organ1.40973341
40MP0009046_muscle_twitch1.39890273
41MP0006276_abnormal_autonomic_nervous1.38592786
42MP0002160_abnormal_reproductive_system1.37844140
43MP0002557_abnormal_social/conspecific_i1.33463164
44MP0008058_abnormal_DNA_repair1.31120937
45MP0002282_abnormal_trachea_morphology1.30801005
46MP0002735_abnormal_chemical_nociception1.30287100
47MP0004742_abnormal_vestibular_system1.29811601
48MP0002572_abnormal_emotion/affect_behav1.29296281
49MP0000631_abnormal_neuroendocrine_gland1.28442189
50MP0004924_abnormal_behavior1.28412525
51MP0005386_behavior/neurological_phenoty1.28412525
52MP0003646_muscle_fatigue1.28385962
53MP0002064_seizures1.27200186
54MP0001984_abnormal_olfaction1.24875223
55MP0001970_abnormal_pain_threshold1.22157722
56MP0002234_abnormal_pharynx_morphology1.22130802
57MP0003718_maternal_effect1.21704059
58MP0002733_abnormal_thermal_nociception1.20845063
59MP0005379_endocrine/exocrine_gland_phen1.19963144
60MP0002102_abnormal_ear_morphology1.18176452
61MP0002163_abnormal_gland_morphology1.16573714
62MP0003252_abnormal_bile_duct1.12314982
63MP0002138_abnormal_hepatobiliary_system1.11197659
64MP0002067_abnormal_sensory_capabilities1.08385638
65MP0001919_abnormal_reproductive_system1.07484043
66MP0001765_abnormal_ion_homeostasis1.05149770
67MP0003121_genomic_imprinting1.01224804
68MP0005075_abnormal_melanosome_morpholog1.01008474
69MP0002063_abnormal_learning/memory/cond0.99018117
70MP0003635_abnormal_synaptic_transmissio0.98268649
71MP0002751_abnormal_autonomic_nervous0.95760738
72MP0010386_abnormal_urinary_bladder0.95337426
73MP0001905_abnormal_dopamine_level0.94272573
74MP0005085_abnormal_gallbladder_physiolo0.93304563
75MP0002734_abnormal_mechanical_nocicepti0.92445287
76MP0005423_abnormal_somatic_nervous0.92388454
77MP0005647_abnormal_sex_gland0.87582738
78MP0001502_abnormal_circadian_rhythm0.84963643
79MP0005332_abnormal_amino_acid0.84779208
80MP0008775_abnormal_heart_ventricle0.84594629
81MP0002095_abnormal_skin_pigmentation0.84473799
82MP0008789_abnormal_olfactory_epithelium0.81314267
83MP0004215_abnormal_myocardial_fiber0.80853891
84MP0005167_abnormal_blood-brain_barrier0.80682178
85MP0000230_abnormal_systemic_arterial0.80664858
86MP0000647_abnormal_sebaceous_gland0.78382553
87MP0001963_abnormal_hearing_physiology0.78220527
88MP0010094_abnormal_chromosome_stability0.76070182
89MP0005389_reproductive_system_phenotype0.70767177
90MP0002269_muscular_atrophy0.59492428
91MP0002928_abnormal_bile_duct0.58404366
92MP0005636_abnormal_mineral_homeostasis0.58156406
93MP0003115_abnormal_respiratory_system0.55501889
94MP0008995_early_reproductive_senescence0.55094290
95MP0003699_abnormal_female_reproductive0.51322177
96MP0004133_heterotaxia0.49535666
97MP0005551_abnormal_eye_electrophysiolog0.49383983
98MP0001324_abnormal_eye_pigmentation0.49203003
99MP0003011_delayed_dark_adaptation0.48665946
100MP0010307_abnormal_tumor_latency0.46052755
101MP0000358_abnormal_cell_content/0.45706055
102MP0001119_abnormal_female_reproductive0.45565406
103MP0001293_anophthalmia0.44328703
104MP0008057_abnormal_DNA_replication0.43191432
105MP0006036_abnormal_mitochondrial_physio0.42394769
106MP0001764_abnormal_homeostasis0.41488222
107MP0004036_abnormal_muscle_relaxation0.40004997
108MP0003633_abnormal_nervous_system0.39691960
109MP0002139_abnormal_hepatobiliary_system0.39278096
110MP0005253_abnormal_eye_physiology0.38982297
111MP0005666_abnormal_adipose_tissue0.38815886
112MP0003890_abnormal_embryonic-extraembry0.38210312
113MP0003111_abnormal_nucleus_morphology0.37359677
114MP0004019_abnormal_vitamin_homeostasis0.37159077
115MP0006035_abnormal_mitochondrial_morpho0.35129036
116MP0002971_abnormal_brown_adipose0.34997996
117MP0005174_abnormal_tail_pigmentation0.33761824
118MP0005409_darkened_coat_color0.33694187
119MP0009115_abnormal_fat_cell0.33474281
120MP0002736_abnormal_nociception_after0.31099739
121MP0003878_abnormal_ear_physiology0.30508213
122MP0005377_hearing/vestibular/ear_phenot0.30508213
123MP0001730_embryonic_growth_arrest0.30432950
124MP0003329_amyloid_beta_deposits0.30167302
125MP0005535_abnormal_body_temperature0.29666794
126MP0003950_abnormal_plasma_membrane0.28776884
127MP0002132_abnormal_respiratory_system0.27425855
128MP0008875_abnormal_xenobiotic_pharmacok0.27096684
129MP0002009_preneoplasia0.26048582
130MP0003631_nervous_system_phenotype0.25378400
131MP0003861_abnormal_nervous_system0.25225834
132MP0005319_abnormal_enzyme/_coenzyme0.24938372
133MP0009278_abnormal_bone_marrow0.24686923
134MP0002084_abnormal_developmental_patter0.24008274
135MP0001968_abnormal_touch/_nociception0.23888240
136MP0005391_vision/eye_phenotype0.23629148
137MP0000313_abnormal_cell_death0.23247269
138MP0003786_premature_aging0.23237782
139MP0004811_abnormal_neuron_physiology0.23049241
140MP0002152_abnormal_brain_morphology0.22925625
141MP0002405_respiratory_system_inflammati0.20786372
142MP0001545_abnormal_hematopoietic_system0.20410375
143MP0005397_hematopoietic_system_phenotyp0.20410375
144MP0001697_abnormal_embryo_size0.18923257
145MP0005365_abnormal_bile_salt0.18235933
146MP0000015_abnormal_ear_pigmentation0.17969407
147MP0001672_abnormal_embryogenesis/_devel0.17642294
148MP0005380_embryogenesis_phenotype0.17642294
149MP0002752_abnormal_somatic_nervous0.17001965
150MP0008872_abnormal_physiological_respon0.16278671
151MP0004043_abnormal_pH_regulation0.16271967
152MP0003984_embryonic_growth_retardation0.15882839
153MP0002169_no_abnormal_phenotype0.15863673
154MP0005195_abnormal_posterior_eye0.15743399
155MP0002873_normal_phenotype0.15600836
156MP0000604_amyloidosis0.15005876
157MP0002229_neurodegeneration0.13299446
158MP0003705_abnormal_hypodermis_morpholog0.13151210
159MP0002693_abnormal_pancreas_physiology0.13128623
160MP0002088_abnormal_embryonic_growth/wei0.13124883
161MP0000432_abnormal_head_morphology0.13104498
162MP0000534_abnormal_ureter_morphology0.12923402
163MP0004145_abnormal_muscle_electrophysio0.12779256
164MP0001661_extended_life_span0.12358629
165MP0002085_abnormal_embryonic_tissue0.12176880

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.28103856
2Abnormal respiratory motile cilium morphology (HP:0005938)9.24418699
3Abnormal respiratory epithelium morphology (HP:0012253)9.24418699
4Rhinitis (HP:0012384)7.61986442
5Abnormal ciliary motility (HP:0012262)7.60419747
6Chronic bronchitis (HP:0004469)7.27305352
7Nasal polyposis (HP:0100582)6.39105221
8Infertility (HP:0000789)6.07897280
9Abnormality of the nasal mucosa (HP:0000433)5.24319184
10Bronchitis (HP:0012387)4.55339166
11Bronchiectasis (HP:0002110)4.51124591
12Pancreatic cysts (HP:0001737)4.40601786
13Male infertility (HP:0003251)4.09460397
14Congenital stationary night blindness (HP:0007642)3.93250504
15True hermaphroditism (HP:0010459)3.85244439
16Medial flaring of the eyebrow (HP:0010747)3.78361933
17Nephronophthisis (HP:0000090)3.70924622
18Recurrent sinusitis (HP:0011108)3.57516319
19Abnormal spermatogenesis (HP:0008669)3.56525348
20Attenuation of retinal blood vessels (HP:0007843)3.29920584
21Recurrent otitis media (HP:0000403)3.20306159
22Chronic hepatic failure (HP:0100626)3.19518860
23Pendular nystagmus (HP:0012043)2.96985735
24Hyperventilation (HP:0002883)2.90560396
25Abnormal rod and cone electroretinograms (HP:0008323)2.86732452
26Gait imbalance (HP:0002141)2.85497193
27Congenital primary aphakia (HP:0007707)2.85345061
28Abnormality of alanine metabolism (HP:0010916)2.83366283
29Hyperalaninemia (HP:0003348)2.83366283
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83366283
31Abolished electroretinogram (ERG) (HP:0000550)2.81606873
32Abnormality of the renal medulla (HP:0100957)2.77988278
33Inability to walk (HP:0002540)2.76710713
34Recurrent bronchitis (HP:0002837)2.74028375
35Tongue fasciculations (HP:0001308)2.68763353
36Azoospermia (HP:0000027)2.66196019
37Abnormality of midbrain morphology (HP:0002418)2.59942572
38Molar tooth sign on MRI (HP:0002419)2.59942572
39Tubulointerstitial nephritis (HP:0001970)2.59465520
40Gaze-evoked nystagmus (HP:0000640)2.57582988
41Muscle fibrillation (HP:0010546)2.50192880
42Progressive inability to walk (HP:0002505)2.47822526
43Nephrogenic diabetes insipidus (HP:0009806)2.44334973
44Progressive cerebellar ataxia (HP:0002073)2.39731705
45Impulsivity (HP:0100710)2.39237513
46Tubular atrophy (HP:0000092)2.36024806
47Renal cortical cysts (HP:0000803)2.34077357
48Sclerocornea (HP:0000647)2.33530913
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30890251
50Genetic anticipation (HP:0003743)2.22956878
51Broad-based gait (HP:0002136)2.21327205
52Lissencephaly (HP:0001339)2.21154925
53Chronic sinusitis (HP:0011109)2.20678353
54Increased corneal curvature (HP:0100692)2.20325688
55Keratoconus (HP:0000563)2.20325688
56Anencephaly (HP:0002323)2.20145456
57Acute necrotizing encephalopathy (HP:0006965)2.19185592
58Polyuria (HP:0000103)2.19129782
59Large for gestational age (HP:0001520)2.18504913
60Poor coordination (HP:0002370)2.15454405
61Concave nail (HP:0001598)2.11434610
62Vaginal atresia (HP:0000148)2.10616811
63Optic disc pallor (HP:0000543)2.09830332
64Tubulointerstitial abnormality (HP:0001969)2.09680342
65Genital tract atresia (HP:0001827)2.09158705
66Bony spicule pigmentary retinopathy (HP:0007737)2.08947968
67Mitochondrial inheritance (HP:0001427)2.08714169
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.08401811
69Aplasia/Hypoplasia of the lens (HP:0008063)2.06340924
703-Methylglutaconic aciduria (HP:0003535)2.06004324
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05633704
72Increased CSF lactate (HP:0002490)2.03486013
73Hypothermia (HP:0002045)2.03065919
74Furrowed tongue (HP:0000221)2.00981251
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2300703
76Dynein arm defect of respiratory motile cilia (HP:0012255)12.9701642
77Absent/shortened dynein arms (HP:0200106)12.9701642
78Acute encephalopathy (HP:0006846)1.98850020
79Progressive macrocephaly (HP:0004481)1.98324887
80Severe muscular hypotonia (HP:0006829)1.96123662
81Male pseudohermaphroditism (HP:0000037)1.95431934
82Abnormality of saccadic eye movements (HP:0000570)1.95218764
83Retinal dysplasia (HP:0007973)1.95093168
84Pachygyria (HP:0001302)1.95023971
85Congenital, generalized hypertrichosis (HP:0004540)1.94475626
86Absent speech (HP:0001344)1.94276749
87Occipital encephalocele (HP:0002085)1.91371207
88Hemiparesis (HP:0001269)1.88212900
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.87121200
90Protruding tongue (HP:0010808)1.87015402
91Decreased circulating renin level (HP:0003351)1.87011618
92Abnormal mitochondria in muscle tissue (HP:0008316)1.86402975
93Optic nerve hypoplasia (HP:0000609)1.83244599
94Febrile seizures (HP:0002373)1.80744961
95Abnormal urine output (HP:0012590)1.80709380
96Patellar aplasia (HP:0006443)1.80287392
97Stomach cancer (HP:0012126)1.80264475
98Impaired smooth pursuit (HP:0007772)1.79731584
99Hepatocellular necrosis (HP:0001404)1.79144979
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.78896150
101Hypoplasia of the fovea (HP:0007750)1.78896150
102Abnormality of the pons (HP:0007361)1.75664296
103Tachypnea (HP:0002789)1.75652898
104Hepatic necrosis (HP:0002605)1.74513923
105Abnormality of macular pigmentation (HP:0008002)1.73266823
106Postaxial hand polydactyly (HP:0001162)1.73174691
107Postaxial foot polydactyly (HP:0001830)1.72724236
108Hypomagnesemia (HP:0002917)1.72630912
109Methylmalonic acidemia (HP:0002912)1.72572794
110Asplenia (HP:0001746)1.71938748
111Aplasia/Hypoplasia of the patella (HP:0006498)1.69984658
112Heterotopia (HP:0002282)1.69467559
113Abnormality of the labia minora (HP:0012880)1.69453190
114Gonadotropin excess (HP:0000837)1.69001984
115Congenital hepatic fibrosis (HP:0002612)1.68895445
116Aplasia/hypoplasia of the uterus (HP:0008684)1.68873237
117Decreased central vision (HP:0007663)1.68221726
118Intestinal atresia (HP:0011100)1.67718756
119Abnormal gallbladder physiology (HP:0012438)1.66865418
120Cholecystitis (HP:0001082)1.66865418
121Abnormality of ocular smooth pursuit (HP:0000617)1.65471505
122Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.62472221
123Stage 5 chronic kidney disease (HP:0003774)1.62205183
124Type 2 muscle fiber atrophy (HP:0003554)1.62015543
125Easy fatigability (HP:0003388)1.61256814
126Facial cleft (HP:0002006)1.60666850
127Dyschromatopsia (HP:0007641)1.59101404
128Tubulointerstitial fibrosis (HP:0005576)1.58593573
129Supernumerary spleens (HP:0009799)1.57551618
130Fatigable weakness (HP:0003473)1.57166966
131Abnormality of the neuromuscular junction (HP:0003398)1.57166966
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.55615674
133Cerebellar dysplasia (HP:0007033)1.55554758
134Spastic tetraparesis (HP:0001285)1.53318528
135Pancreatic fibrosis (HP:0100732)1.53211506
136Abnormal biliary tract physiology (HP:0012439)1.46160325
137Bile duct proliferation (HP:0001408)1.46160325
138Abnormal drinking behavior (HP:0030082)1.45874529
139Polydipsia (HP:0001959)1.45874529
140Abnormality of renal excretion (HP:0011036)1.45202167
141Oculomotor apraxia (HP:0000657)1.41891464
142Asymmetric septal hypertrophy (HP:0001670)1.41702654
143Abnormality of the renal cortex (HP:0011035)1.40642843
144Short ribs (HP:0000773)1.40251463
145Sensory axonal neuropathy (HP:0003390)1.39935303
146Renal dysplasia (HP:0000110)1.39452219
147Hypoplasia of the capital femoral epiphysis (HP:0003090)1.35499969
148Broad foot (HP:0001769)1.34933412
149Renovascular hypertension (HP:0100817)1.34557539
150Chronic otitis media (HP:0000389)1.34380015
151Slow saccadic eye movements (HP:0000514)1.34336800
152Abnormality of permanent molar morphology (HP:0011071)1.34245386
153Abnormality of the dental root (HP:0006486)1.34245386
154Taurodontia (HP:0000679)1.34245386
155Muscle fiber atrophy (HP:0100295)1.33211435
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.31374952
157Microglossia (HP:0000171)1.31226478
158Limb ataxia (HP:0002070)1.29972038
159Choroideremia (HP:0001139)1.26796320
160Bundle branch block (HP:0011710)1.25766600
161Cystic liver disease (HP:0006706)1.25306112
162Abnormality of molar (HP:0011077)1.25060720
163Abnormality of molar morphology (HP:0011070)1.25060720
164Constricted visual fields (HP:0001133)1.24994080
165Papillary thyroid carcinoma (HP:0002895)1.23832075
166Abnormality of the dental pulp (HP:0006479)1.22492814
167Median cleft lip (HP:0000161)1.21548740
168Type II lissencephaly (HP:0007260)1.20582724
169Double outlet right ventricle (HP:0001719)1.20260459
170Congenital malformation of the right heart (HP:0011723)1.20260459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.01218086
2PDK39.01218086
3PDK26.11797418
4FRK5.07773582
5TESK14.96452530
6PRKD33.82364315
7ICK3.66655980
8ADRBK23.31768757
9BMPR1B3.16576651
10MAP4K23.03697573
11WNK32.59143912
12GRK12.51316081
13ZAK2.47622938
14ACVR1B2.37067061
15INSRR2.27790498
16TLK12.21005893
17TAOK32.12407852
18NUAK11.96549459
19WNK41.90479902
20STK391.89793421
21PTK2B1.89508724
22CASK1.87895122
23MAPK131.84951032
24MAP3K41.74303682
25DAPK21.70138056
26TXK1.65198751
27OXSR11.59003209
28TNIK1.57721786
29STK381.46124788
30PNCK1.37658057
31TRIM281.37468059
32NEK21.35024861
33MKNK21.30863222
34TGFBR11.27759544
35PLK41.27286282
36DYRK1B1.21055457
37PLK21.17064573
38DYRK21.16307796
39ADRBK11.15847586
40PDK11.15206582
41IRAK11.14470006
42MARK11.14373061
43LMTK21.09548695
44PAK31.08911098
45TIE11.01989653
46BCR0.98294368
47PRKCE0.95685119
48PHKG10.89432585
49PHKG20.89432585
50CAMKK20.87616729
51BCKDK0.86563775
52MAP3K100.84785534
53CHEK20.83657420
54CSNK1G20.81850192
55CDK120.81331750
56CSNK1G10.77428746
57KIT0.76852244
58VRK10.76760285
59TYRO30.74631481
60CSNK1G30.74370322
61TESK20.72505071
62CCNB10.71732195
63MKNK10.69481019
64ERBB30.67869778
65DYRK30.67718872
66WEE10.67568866
67GRK70.65345104
68MAPKAPK30.64570848
69PIK3CA0.64177393
70EPHA40.63243486
71RIPK40.63136485
72PDPK10.60538388
73MAPK150.58604501
74BRSK20.58369140
75IKBKB0.58363858
76WNK10.57827164
77NTRK30.57737832
78TTK0.56311323
79RPS6KA50.55995182
80MAP2K60.54834828
81PASK0.54450552
82STK30.54408489
83CSNK1A1L0.53934445
84NME10.52551842
85IRAK20.51552370
86FLT30.50016051
87FGFR20.49726750
88PRKACA0.49204026
89SIK20.49033322
90YES10.48790311
91PLK30.48166742
92STK38L0.47307587
93CHEK10.47138837
94CSNK1A10.46157206
95CAMK10.44767614
96TEC0.44679826
97MST40.44066656
98EIF2AK30.43473161
99PRKCI0.42137199
100STK160.41551139
101NLK0.39984526
102OBSCN0.38004252
103CHUK0.37890598
104MUSK0.35850378
105FER0.35159830
106PAK10.33895052
107ITK0.33631346
108CDK30.32685468
109PINK10.31961717
110TNK20.31625982
111CDK80.31524617
112NEK60.30853475
113CDC70.30311979
114ATM0.29631021
115MAP2K10.29030175
116RIPK10.28578651
117PLK10.27309997
118EEF2K0.26878561
119ATR0.26199562
120PKN10.25897651
121PRKCG0.25709097
122BRSK10.22812327
123PRKG20.21544275
124PBK0.18403867
125CAMK1G0.17688513
126AKT30.16944811
127MTOR0.16284386
128MARK30.15993642
129ZAP700.15687223
130NTRK20.15464568
131PDGFRB0.14046630
132PAK20.12954399
133CSNK2A20.12320703
134EGFR0.12310202
135CSNK2A10.12101544
136CDK150.12005567
137PRKCZ0.11797307
138CDK60.09513485
139CDK180.09064288
140CDK11A0.08600046
141PRKG10.08066976
142BRAF0.07829965
143PRKAA10.07458443
144MARK20.07306032
145CDK20.07280215
146CSNK1D0.07244123
147PRKCQ0.07026795
148RPS6KA10.06549275
149PAK40.06351523
150GSK3B0.05936173
151MAPKAPK50.05930088
152RPS6KB10.05878481
153CDK140.05407240
154STK100.04691831
155MAP3K50.04223504
156CAMKK10.03437912
157PRKACG0.03099952
158CDK10.02876877
159CDK40.02812950
160PRKCD0.02189824
161MAP3K10.01517309
162CAMK2A0.01229764
163AURKA0.00704229
164PRKCA0.00461158
165MAP4K1-0.0140189
166STK11-0.0064785
167MAPK8-0.0057659
168MAP2K7-0.0044145
169PRKCB-0.0037760
170PRKDC-0.0008824
171CSF1R-0.0008513

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.32684032
2Fatty acid biosynthesis_Homo sapiens_hsa000614.00074885
3Pyruvate metabolism_Homo sapiens_hsa006203.48178593
4Vitamin B6 metabolism_Homo sapiens_hsa007503.27399139
5Basal transcription factors_Homo sapiens_hsa030223.11090630
6Propanoate metabolism_Homo sapiens_hsa006402.98252062
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.86423711
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.84496892
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.69854687
10Linoleic acid metabolism_Homo sapiens_hsa005912.63286773
11Phototransduction_Homo sapiens_hsa047442.59763213
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58849618
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57540598
14Butanoate metabolism_Homo sapiens_hsa006502.47820302
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.42788998
16Pentose phosphate pathway_Homo sapiens_hsa000302.42325008
17Selenocompound metabolism_Homo sapiens_hsa004502.40177000
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38716242
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.38405719
20Glucagon signaling pathway_Homo sapiens_hsa049222.29433763
21Nitrogen metabolism_Homo sapiens_hsa009102.26693655
22Oxidative phosphorylation_Homo sapiens_hsa001902.25147556
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23220118
24Maturity onset diabetes of the young_Homo sapiens_hsa049502.15275511
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13260795
26Nicotine addiction_Homo sapiens_hsa050332.06535333
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.98915084
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97971025
29Glycerolipid metabolism_Homo sapiens_hsa005611.90607920
30Oocyte meiosis_Homo sapiens_hsa041141.89774542
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81366646
32Fanconi anemia pathway_Homo sapiens_hsa034601.78447252
33Protein export_Homo sapiens_hsa030601.77051442
34PPAR signaling pathway_Homo sapiens_hsa033201.75755379
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70928338
36RNA polymerase_Homo sapiens_hsa030201.68496252
37Parkinsons disease_Homo sapiens_hsa050121.67664362
38Tryptophan metabolism_Homo sapiens_hsa003801.67626976
39Mineral absorption_Homo sapiens_hsa049781.66333366
40Carbon metabolism_Homo sapiens_hsa012001.62852247
41Caffeine metabolism_Homo sapiens_hsa002321.53753159
42Huntingtons disease_Homo sapiens_hsa050161.51462427
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50429160
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48160162
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.46583895
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.41749651
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.36930767
48Cardiac muscle contraction_Homo sapiens_hsa042601.36184627
49Fructose and mannose metabolism_Homo sapiens_hsa000511.35200227
50Olfactory transduction_Homo sapiens_hsa047401.32428110
51Fat digestion and absorption_Homo sapiens_hsa049751.25284435
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25210731
53Peroxisome_Homo sapiens_hsa041461.24773984
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22660022
55Purine metabolism_Homo sapiens_hsa002301.22466757
56Biosynthesis of amino acids_Homo sapiens_hsa012301.21383214
57Ether lipid metabolism_Homo sapiens_hsa005651.19501869
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18893211
59RNA transport_Homo sapiens_hsa030131.18773310
60Glutathione metabolism_Homo sapiens_hsa004801.18347038
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18205316
62Renin-angiotensin system_Homo sapiens_hsa046141.17468014
63Morphine addiction_Homo sapiens_hsa050321.16090425
64RNA degradation_Homo sapiens_hsa030181.15883161
65Dorso-ventral axis formation_Homo sapiens_hsa043201.14395965
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14044326
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.13108617
68Collecting duct acid secretion_Homo sapiens_hsa049661.12727282
69Amphetamine addiction_Homo sapiens_hsa050311.12308424
70Fatty acid degradation_Homo sapiens_hsa000711.09871474
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07554917
72Fatty acid metabolism_Homo sapiens_hsa012121.07169102
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06202975
74One carbon pool by folate_Homo sapiens_hsa006701.05680873
75Type I diabetes mellitus_Homo sapiens_hsa049401.05262238
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04417458
77Asthma_Homo sapiens_hsa053101.01415274
78Alzheimers disease_Homo sapiens_hsa050101.00432154
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.99249100
80mRNA surveillance pathway_Homo sapiens_hsa030150.98722837
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96817604
82Antigen processing and presentation_Homo sapiens_hsa046120.95815861
83Non-homologous end-joining_Homo sapiens_hsa034500.93376227
84Chemical carcinogenesis_Homo sapiens_hsa052040.91325467
85Retinol metabolism_Homo sapiens_hsa008300.90783461
86Graft-versus-host disease_Homo sapiens_hsa053320.88219042
87Systemic lupus erythematosus_Homo sapiens_hsa053220.87838421
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86260971
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85681031
90GABAergic synapse_Homo sapiens_hsa047270.84783827
91Regulation of autophagy_Homo sapiens_hsa041400.81653967
92Renin secretion_Homo sapiens_hsa049240.80052582
93Serotonergic synapse_Homo sapiens_hsa047260.79258598
94Allograft rejection_Homo sapiens_hsa053300.79170894
95Glutamatergic synapse_Homo sapiens_hsa047240.76889337
96beta-Alanine metabolism_Homo sapiens_hsa004100.76276024
97Bile secretion_Homo sapiens_hsa049760.75409753
98Proteasome_Homo sapiens_hsa030500.75158311
99N-Glycan biosynthesis_Homo sapiens_hsa005100.72947881
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72465572
101Primary immunodeficiency_Homo sapiens_hsa053400.69789938
102Synaptic vesicle cycle_Homo sapiens_hsa047210.69708284
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67356472
104Autoimmune thyroid disease_Homo sapiens_hsa053200.66934571
105Insulin secretion_Homo sapiens_hsa049110.64205404
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63763158
107Steroid biosynthesis_Homo sapiens_hsa001000.61921334
108Thyroid hormone synthesis_Homo sapiens_hsa049180.60948938
109Arachidonic acid metabolism_Homo sapiens_hsa005900.60175514
110Legionellosis_Homo sapiens_hsa051340.59793668
111Hedgehog signaling pathway_Homo sapiens_hsa043400.58302490
112Inositol phosphate metabolism_Homo sapiens_hsa005620.56389659
113Protein digestion and absorption_Homo sapiens_hsa049740.55126310
114Histidine metabolism_Homo sapiens_hsa003400.54486953
115Ovarian steroidogenesis_Homo sapiens_hsa049130.53570023
116Metabolic pathways_Homo sapiens_hsa011000.53208094
117Estrogen signaling pathway_Homo sapiens_hsa049150.52979570
118Pyrimidine metabolism_Homo sapiens_hsa002400.52797969
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51593794
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50838186
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50309658
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49920567
123Vitamin digestion and absorption_Homo sapiens_hsa049770.49809803
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.49089256
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48235974
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47235395
127Calcium signaling pathway_Homo sapiens_hsa040200.46390403
128Homologous recombination_Homo sapiens_hsa034400.46233373
129Pancreatic secretion_Homo sapiens_hsa049720.45074452
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.44778526
131Ribosome_Homo sapiens_hsa030100.42805503
132Long-term potentiation_Homo sapiens_hsa047200.42460409
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42082776
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.41284047
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40892828
136Circadian rhythm_Homo sapiens_hsa047100.40782847
137ABC transporters_Homo sapiens_hsa020100.40105110
138Taste transduction_Homo sapiens_hsa047420.38947728
139Dopaminergic synapse_Homo sapiens_hsa047280.37766537
140Endocytosis_Homo sapiens_hsa041440.37264399
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36492975
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35306589
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32845598
144Gastric acid secretion_Homo sapiens_hsa049710.32701749
145Salivary secretion_Homo sapiens_hsa049700.32486469
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22990035
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22789452
148Salmonella infection_Homo sapiens_hsa051320.20914645
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18836700
150Sulfur metabolism_Homo sapiens_hsa009200.18823644
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.17930252
152AMPK signaling pathway_Homo sapiens_hsa041520.16801162
153cAMP signaling pathway_Homo sapiens_hsa040240.15274871
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14870754
155Alcoholism_Homo sapiens_hsa050340.14787117
156Circadian entrainment_Homo sapiens_hsa047130.13895285
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13399092
158Spliceosome_Homo sapiens_hsa030400.13231541
159Sulfur relay system_Homo sapiens_hsa041220.12672153
160Viral carcinogenesis_Homo sapiens_hsa052030.11984825
161Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11637707

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