ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	9.97425093
2	cilium or flagellum-dependent cell motility (GO:0001539)	9.72642025
3	spermatid development (GO:0007286)	9.53400897
4	motile cilium assembly (GO:0044458)	9.52087274
5	cilium movement (GO:0003341)	8.46790990
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	7.79678803
7	single fertilization (GO:0007338)	7.68958285
8	regulation of cilium movement (GO:0003352)	7.54456679
9	sperm capacitation (GO:0048240)	7.12196916
10	spermatid nucleus differentiation (GO:0007289)	6.95056019
11	synaptonemal complex organization (GO:0070193)	6.88461943
12	male meiosis (GO:0007140)	6.86588452
13	synaptonemal complex assembly (GO:0007130)	6.84504764
14	microtubule depolymerization (GO:0007019)	6.62250324
15	piRNA metabolic process (GO:0034587)	6.42943884
16	negative regulation of inclusion body assembly (GO:0090084)	6.35082713
17	fertilization (GO:0009566)	6.31268606
18	spermatogenesis (GO:0007283)	6.24223336
19	male gamete generation (GO:0048232)	6.21855730
20	sexual reproduction (GO:0019953)	6.01497339
21	organic cation transport (GO:0015695)	5.86873432
22	gamete generation (GO:0007276)	5.72004019
23	calcium ion-dependent exocytosis (GO:0017156)	5.64298737
24	regulation of inclusion body assembly (GO:0090083)	5.39542965
25	single strand break repair (GO:0000012)	5.33057904
26	germ cell development (GO:0007281)	5.23128786
27	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.19468087
28	cell recognition (GO:0008037)	5.13341800
29	glycerol ether metabolic process (GO:0006662)	5.08821441
30	ventricular system development (GO:0021591)	4.99584362
31	ether metabolic process (GO:0018904)	4.70334106
32	chromosome organization involved in meiosis (GO:0070192)	4.66085322
33	multicellular organismal reproductive process (GO:0048609)	4.50901426
34	regulation of microtubule-based movement (GO:0060632)	4.48360310
35	protein K11-linked deubiquitination (GO:0035871)	4.41649357
36	microtubule severing (GO:0051013)	4.24950054
37	chromosome condensation (GO:0030261)	4.22922303
38	male meiosis I (GO:0007141)	4.18305866
39	DNA methylation involved in gamete generation (GO:0043046)	4.18286530
40	meiotic nuclear division (GO:0007126)	4.04456659
41	monoubiquitinated protein deubiquitination (GO:0035520)	3.99867077
42	seminiferous tubule development (GO:0072520)	3.92827599
43	DNA packaging (GO:0006323)	3.90978735
44	chaperone-mediated protein complex assembly (GO:0051131)	3.79199777
45	left/right pattern formation (GO:0060972)	3.65424393
46	multicellular organismal development (GO:0007275)	3.63374277
47	genitalia morphogenesis (GO:0035112)	3.57572846
48	sequestering of actin monomers (GO:0042989)	3.54542215
49	microtubule polymerization or depolymerization (GO:0031109)	3.48519288
50	meiosis I (GO:0007127)	3.28985067
51	glycolytic process (GO:0006096)	3.16316699
52	alditol metabolic process (GO:0019400)	3.14140485
53	nucleoside diphosphate phosphorylation (GO:0006165)	3.12328389
54	centriole assembly (GO:0098534)	3.10157820
55	nucleus organization (GO:0006997)	3.09535321
56	GTP biosynthetic process (GO:0006183)	3.09414878
57	polyol catabolic process (GO:0046174)	3.06228409
58	meiotic cell cycle (GO:0051321)	3.01437506
59	protein refolding (GO:0042026)	2.99250783
60	protein polyglutamylation (GO:0018095)	2.96452240
61	cilium organization (GO:0044782)	2.91536620
62	positive regulation of macrophage activation (GO:0043032)	2.90871803
63	cilium assembly (GO:0042384)	2.82763340
64	lactate metabolic process (GO:0006089)	2.82430146
65	amino-acid betaine transport (GO:0015838)	2.81619396
66	carnitine transport (GO:0015879)	2.81619396
67	chromatin silencing (GO:0006342)	2.80163875
68	glycerol metabolic process (GO:0006071)	2.77690847
69	microtubule-based movement (GO:0007018)	2.76734567
70	cellular component assembly involved in morphogenesis (GO:0010927)	2.76128132
71	UTP biosynthetic process (GO:0006228)	2.75097833
72	regulation of spindle checkpoint (GO:0090231)	2.73173072
73	centriole replication (GO:0007099)	2.72130471
74	protein localization to cilium (GO:0061512)	2.69132807
75	carnitine transmembrane transport (GO:1902603)	2.66098258
76	cilium morphogenesis (GO:0060271)	2.59370524
77	synapsis (GO:0007129)	2.56608310
78	nucleosome disassembly (GO:0006337)	2.56437911
79	protein-DNA complex disassembly (GO:0032986)	2.56437911
80	mitotic sister chromatid cohesion (GO:0007064)	2.55952707
81	meiotic cell cycle process (GO:1903046)	2.55287373
82	axoneme assembly (GO:0035082)	2.53748957
83	UTP metabolic process (GO:0046051)	2.50554798
84	macroautophagy (GO:0016236)	2.50518435
85	intraciliary transport (GO:0042073)	2.48802586
86	interferon-gamma secretion (GO:0072643)	2.41669965
87	cell redox homeostasis (GO:0045454)	2.40920683
88	cell wall macromolecule catabolic process (GO:0016998)	15.8831631
89	cell wall macromolecule metabolic process (GO:0044036)	15.8831631
90	fusion of sperm to egg plasma membrane (GO:0007342)	14.5458620
91	sperm motility (GO:0030317)	13.8185478
92	acrosome assembly (GO:0001675)	11.9006630
93	multicellular organism reproduction (GO:0032504)	11.7409207
94	sperm-egg recognition (GO:0035036)	11.6823607
95	acrosome reaction (GO:0007340)	11.4093919
96	plasma membrane fusion (GO:0045026)	11.1050344
97	epithelial cilium movement (GO:0003351)	10.6154705
98	binding of sperm to zona pellucida (GO:0007339)	10.5870620
99	cell-cell recognition (GO:0009988)	10.4785160
100	reproduction (GO:0000003)	10.4684879

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	9.04015774
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.78455989
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.62897971
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.54912226
5	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.44442764
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.63664362
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.56817707
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.36559116
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.25095442
10	VDR_22108803_ChIP-Seq_LS180_Human	2.23839219
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.23121721
12	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.21627891
13	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	2.06166593
14	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	2.00932580
15	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.99530280
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.97982738
17	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.95735503
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.89885693
19	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.84047650
20	KDM2B_26808549_Chip-Seq_REH_Human	1.83261035
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.80569336
22	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.80484276
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74814693
24	STAT1_17558387_ChIP-Seq_HELA_Human	1.74675708
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.74207340
26	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.70241126
27	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.69496124
28	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.64356260
29	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.63233032
30	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.63075302
31	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.60923722
32	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.58083404
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.57012707
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.55059167
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50041456
36	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48047507
37	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.46248343
38	REST_21632747_ChIP-Seq_MESCs_Mouse	1.40735463
39	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.40475729
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40036030
41	CBP_20019798_ChIP-Seq_JUKART_Human	1.40036030
42	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.39290494
43	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.37948469
44	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36967405
45	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36712864
46	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.35287219
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.32544494
48	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.31762775
49	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.31531574
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.30325939
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28512025
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28504620
53	P53_22387025_ChIP-Seq_ESCs_Mouse	1.27591021
54	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.27030156
55	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.26131886
56	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.22783048
57	P300_18555785_Chip-Seq_ESCs_Mouse	1.22179453
58	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.21733637
59	P53_21459846_ChIP-Seq_SAOS-2_Human	1.20896136
60	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20104547
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20104547
62	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.18704125
63	GF1_26923725_Chip-Seq_HPCs_Mouse	1.18081114
64	KLF4_18555785_Chip-Seq_ESCs_Mouse	1.15086121
65	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.13787189
66	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.13234663
67	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.12755154
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.12543274
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12497638
70	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.11277228
71	ESRRB_18555785_Chip-Seq_ESCs_Mouse	1.09417190
72	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.09281292
73	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.09021010
74	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.07911119
75	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07287175
76	SOX9_26525672_Chip-Seq_HEART_Mouse	1.07063327
77	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.05936426
78	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05518252
79	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05378264
80	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.04966230
81	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	1.03327310
82	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.02416649
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01405260
84	PU1_27457419_Chip-Seq_LIVER_Mouse	1.00426546
85	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.99539662
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99304005
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.99188631
88	GF1B_26923725_Chip-Seq_HPCs_Mouse	0.98718408
89	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.98062954
90	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96755922
91	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.96658358
92	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96298984
93	NFYB_21822215_ChIP-Seq_K562_Human	0.95905647
94	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.95845544
95	FUS_26573619_Chip-Seq_HEK293_Human	0.94718425
96	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.94272174
97	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93852564
98	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.92357603
99	LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.90580838
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.90576105

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003698_abnormal_male_reproductive	6.20859385
2	MP0001929_abnormal_gametogenesis	5.62340110
3	MP0008877_abnormal_DNA_methylation	4.08444885
4	MP0002210_abnormal_sex_determination	3.44781405
5	MP0002161_abnormal_fertility/fecundity	3.37868417
6	MP0001145_abnormal_male_reproductive	2.92663827
7	MP0005670_abnormal_white_adipose	2.63772671
8	MP0000653_abnormal_sex_gland	2.54473354
9	MP0002653_abnormal_ependyma_morphology	2.19732570
10	MP0005410_abnormal_fertilization	16.3881571
11	MP0005623_abnormal_meninges_morphology	1.48333960
12	MP0004233_abnormal_muscle_weight	1.44715906
13	MP0002160_abnormal_reproductive_system	1.42980845
14	MP0002282_abnormal_trachea_morphology	1.40515549
15	MP0001765_abnormal_ion_homeostasis	1.33014485
16	MP0002102_abnormal_ear_morphology	1.20913371
17	MP0008058_abnormal_DNA_repair	1.11730844
18	MP0009046_muscle_twitch	1.07228436
19	MP0001984_abnormal_olfaction	1.00958604
20	MP0005647_abnormal_sex_gland	0.98779338
21	MP0003646_muscle_fatigue	0.98071670
22	MP0002234_abnormal_pharynx_morphology	0.94858815
23	MP0005636_abnormal_mineral_homeostasis	0.75689948
24	MP0005389_reproductive_system_phenotype	0.70444760
25	MP0003011_delayed_dark_adaptation	0.66505910
26	MP0002928_abnormal_bile_duct	0.63765347
27	MP0008995_early_reproductive_senescence	0.62236802
28	MP0001324_abnormal_eye_pigmentation	0.59634981
29	MP0004019_abnormal_vitamin_homeostasis	0.54730613
30	MP0002736_abnormal_nociception_after	0.53980391
31	MP0005551_abnormal_eye_electrophysiolog	0.53741016
32	MP0003115_abnormal_respiratory_system	0.51754053
33	MP0005666_abnormal_adipose_tissue	0.50724114
34	MP0004036_abnormal_muscle_relaxation	0.47722394
35	MP0010094_abnormal_chromosome_stability	0.45038989
36	MP0002971_abnormal_brown_adipose	0.44700521
37	MP0002269_muscular_atrophy	0.44138707
38	MP0001764_abnormal_homeostasis	0.43426060
39	MP0002139_abnormal_hepatobiliary_system	0.43336559
40	MP0003699_abnormal_female_reproductive	0.42901943
41	MP0003878_abnormal_ear_physiology	0.42699596
42	MP0005377_hearing/vestibular/ear_phenot	0.42699596
43	MP0005253_abnormal_eye_physiology	0.42632721
44	MP0003329_amyloid_beta_deposits	0.42464690
45	MP0000358_abnormal_cell_content/	0.40930816
46	MP0006036_abnormal_mitochondrial_physio	0.39408697
47	MP0004742_abnormal_vestibular_system	0.38489027
48	MP0000569_abnormal_digit_pigmentation	0.36832031
49	MP0001968_abnormal_touch/_nociception	0.36606334
50	MP0003950_abnormal_plasma_membrane	0.35494584
51	MP0003633_abnormal_nervous_system	0.35281282
52	MP0009115_abnormal_fat_cell	0.34167076
53	MP0002693_abnormal_pancreas_physiology	0.33660760
54	MP0004811_abnormal_neuron_physiology	0.32945372
55	MP0001293_anophthalmia	0.32793074
56	MP0004133_heterotaxia	0.30915566
57	MP0001119_abnormal_female_reproductive	0.30156465
58	MP0008057_abnormal_DNA_replication	0.29411232
59	MP0005391_vision/eye_phenotype	0.29041284
60	MP0005083_abnormal_biliary_tract	0.28805376
61	MP0005423_abnormal_somatic_nervous	0.28726016
62	MP0004145_abnormal_muscle_electrophysio	0.27050264
63	MP0004270_analgesia	0.26994123
64	MP0006035_abnormal_mitochondrial_morpho	0.26992444
65	MP0001727_abnormal_embryo_implantation	0.26737360
66	MP0003631_nervous_system_phenotype	0.26158745
67	MP0008569_lethality_at_weaning	0.25138256
68	MP0002152_abnormal_brain_morphology	0.25083125
69	MP0000604_amyloidosis	0.24525183
70	MP0001849_ear_inflammation	0.22601803
71	MP0002132_abnormal_respiratory_system	0.22496979
72	MP0003861_abnormal_nervous_system	0.22345494
73	MP0000751_myopathy	0.21451339
74	MP0010307_abnormal_tumor_latency	0.21426662
75	MP0006072_abnormal_retinal_apoptosis	0.20942765
76	MP0002169_no_abnormal_phenotype	0.20880227
77	MP0002873_normal_phenotype	0.20634854
78	MP0005365_abnormal_bile_salt	0.20619494
79	MP0002229_neurodegeneration	0.20566405
80	MP0003111_abnormal_nucleus_morphology	0.20559014
81	MP0000534_abnormal_ureter_morphology	0.20379688
82	MP0003786_premature_aging	0.19854951
83	MP0002752_abnormal_somatic_nervous	0.19613139
84	MP0005319_abnormal_enzyme/_coenzyme	0.19357008
85	MP0001348_abnormal_lacrimal_gland	0.18926663
86	MP0003942_abnormal_urinary_system	0.18551343
87	MP0002909_abnormal_adrenal_gland	0.17960467
88	MP0005195_abnormal_posterior_eye	0.17835275
89	MP0008875_abnormal_xenobiotic_pharmacok	0.16953087
90	MP0002572_abnormal_emotion/affect_behav	0.16566385
91	MP0005397_hematopoietic_system_phenotyp	0.16387926
92	MP0001545_abnormal_hematopoietic_system	0.16387926
93	MP0003948_abnormal_gas_homeostasis	0.16189462
94	MP0004084_abnormal_cardiac_muscle	0.16151585
95	MP0005174_abnormal_tail_pigmentation	0.15725376
96	MP0001529_abnormal_vocalization	0.15275665
97	MP0003959_abnormal_lean_body	0.14835154
98	MP0005535_abnormal_body_temperature	0.14598197
99	MP0001963_abnormal_hearing_physiology	0.14536556
100	MP0000462_abnormal_digestive_system	0.14004226

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.70541911
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.70541911
3	Abnormal respiratory motile cilium physiology (HP:0012261)	9.49877981
4	Abnormal ciliary motility (HP:0012262)	7.93641754
5	Chronic bronchitis (HP:0004469)	7.46443190
6	Rhinitis (HP:0012384)	7.39988106
7	Infertility (HP:0000789)	6.29705918
8	Nasal polyposis (HP:0100582)	6.23094362
9	Abnormality of the nasal mucosa (HP:0000433)	5.11871715
10	Bronchitis (HP:0012387)	4.37741788
11	Bronchiectasis (HP:0002110)	4.34413292
12	Male infertility (HP:0003251)	4.16952100
13	Nephronophthisis (HP:0000090)	3.90603135
14	Recurrent sinusitis (HP:0011108)	3.73506986
15	Recurrent otitis media (HP:0000403)	3.18075897
16	Abnormal spermatogenesis (HP:0008669)	3.06267783
17	Abnormality of the renal medulla (HP:0100957)	2.95496150
18	Tubulointerstitial nephritis (HP:0001970)	2.93908061
19	Medial flaring of the eyebrow (HP:0010747)	2.92036997
20	Abnormality of midbrain morphology (HP:0002418)	2.61245834
21	Molar tooth sign on MRI (HP:0002419)	2.61245834
22	Tubular atrophy (HP:0000092)	2.34400820
23	Recurrent bronchitis (HP:0002837)	2.31940853
24	Tubulointerstitial abnormality (HP:0001969)	2.18473656
25	Impulsivity (HP:0100710)	2.00452067
26	Absent/shortened dynein arms (HP:0200106)	14.0341074
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	14.0341074
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	13.1333501
29	Gait imbalance (HP:0002141)	1.99883755
30	Azoospermia (HP:0000027)	1.99500677
31	Congenital primary aphakia (HP:0007707)	1.97176826
32	Asymmetric septal hypertrophy (HP:0001670)	1.89634458
33	Cholecystitis (HP:0001082)	1.86815835
34	Abnormal gallbladder physiology (HP:0012438)	1.86815835
35	Gonadotropin excess (HP:0000837)	1.86231602
36	Chronic sinusitis (HP:0011109)	1.79782117
37	Dyschromatopsia (HP:0007641)	1.74116647
38	Spastic tetraparesis (HP:0001285)	1.73826937
39	Postaxial foot polydactyly (HP:0001830)	1.73352028
40	Decreased central vision (HP:0007663)	1.69714657
41	Nephrogenic diabetes insipidus (HP:0009806)	1.67312500
42	Stage 5 chronic kidney disease (HP:0003774)	1.66759358
43	Aplasia/Hypoplasia of the lens (HP:0008063)	1.63075104
44	Abnormal biliary tract physiology (HP:0012439)	1.62447317
45	Bile duct proliferation (HP:0001408)	1.62447317
46	Abnormality of permanent molar morphology (HP:0011071)	1.59928673
47	Abnormality of the dental root (HP:0006486)	1.59928673
48	Taurodontia (HP:0000679)	1.59928673
49	Heterotopia (HP:0002282)	1.58027452
50	Abnormality of renal excretion (HP:0011036)	1.57521643
51	Congenital hepatic fibrosis (HP:0002612)	1.55676548
52	Abnormality of the renal cortex (HP:0011035)	1.54867579
53	Bundle branch block (HP:0011710)	1.52852004
54	Vaginal atresia (HP:0000148)	1.50078309
55	Tubulointerstitial fibrosis (HP:0005576)	1.49974120
56	Postaxial hand polydactyly (HP:0001162)	1.49259149
57	Abnormality of molar (HP:0011077)	1.49073685
58	Abnormality of molar morphology (HP:0011070)	1.49073685
59	Optic nerve hypoplasia (HP:0000609)	1.48754921
60	Abnormal drinking behavior (HP:0030082)	1.47315709
61	Polydipsia (HP:0001959)	1.47315709
62	Abnormality of the dental pulp (HP:0006479)	1.47043154
63	Poor coordination (HP:0002370)	1.46944819
64	Oculomotor apraxia (HP:0000657)	1.45690740
65	Genital tract atresia (HP:0001827)	1.45078372
66	Abnormality of saccadic eye movements (HP:0000570)	1.43071167
67	Pancreatic fibrosis (HP:0100732)	1.40620152
68	Choroideremia (HP:0001139)	1.39433960
69	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.39165642
70	Constricted visual fields (HP:0001133)	1.39035173
71	Cystic liver disease (HP:0006706)	1.38004876
72	Sensory axonal neuropathy (HP:0003390)	1.36584129
73	Fibular hypoplasia (HP:0003038)	1.35725114
74	Vascular calcification (HP:0004934)	1.34654135
75	Abnormality of ocular smooth pursuit (HP:0000617)	1.33044520
76	True hermaphroditism (HP:0010459)	1.32952531
77	Short ribs (HP:0000773)	1.32818266
78	Tongue fasciculations (HP:0001308)	1.31883026
79	Impaired smooth pursuit (HP:0007772)	1.29634137
80	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.29418606
81	Bell-shaped thorax (HP:0001591)	1.27918622
82	Abnormality of the lower motor neuron (HP:0002366)	1.26839603
83	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.26640589
84	Hemorrhage of the eye (HP:0011885)	1.26208065
85	Supernumerary spleens (HP:0009799)	1.25998602
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.24893758
87	Retrobulbar optic neuritis (HP:0100654)	1.24514619
88	Optic neuritis (HP:0100653)	1.24514619
89	Congenital malformation of the right heart (HP:0011723)	1.21936395
90	Double outlet right ventricle (HP:0001719)	1.21936395
91	Abnormality of dentin (HP:0010299)	1.21868678
92	Cardiovascular calcification (HP:0011915)	1.21680444
93	Abnormality of the neuromuscular junction (HP:0003398)	1.20146300
94	Fatigable weakness (HP:0003473)	1.20146300
95	Muscle fibrillation (HP:0010546)	1.19133076
96	Facial cleft (HP:0002006)	1.18730463
97	Renal dysplasia (HP:0000110)	1.16086309
98	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.14731018
99	Renovascular hypertension (HP:0100817)	1.14619660
100	Easy fatigability (HP:0003388)	1.13277407

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK4	9.79997087
2	PDK3	9.79997087
3	PDK2	6.37641191
4	TESK1	4.06665431
5	PRKD3	3.23962025
6	ICK	3.07445926
7	PTK2B	1.69137909
8	WNK4	1.62410245
9	STK39	1.62223213
10	PNCK	1.57595966
11	DYRK1B	1.24010808
12	STK38	1.12342854
13	PDK1	1.12098527
14	NEK2	1.07463062
15	IRAK1	1.04649212
16	LMTK2	0.91559160
17	DYRK3	0.91374134
18	IRAK2	0.66395055
19	MAP2K6	0.64646543
20	TYRO3	0.62467860
21	MAPK15	0.61927476
22	WNK1	0.56686093
23	NTRK2	0.55853798
24	PLK4	0.54171498
25	PASK	0.53838403
26	RIPK4	0.53376300
27	PDPK1	0.50829305
28	CHEK2	0.44812368
29	CAMK1G	0.44160585
30	CCNB1	0.44101966
31	STK3	0.40084023
32	MUSK	0.36289074
33	TTK	0.35984840
34	CHEK1	0.32914868
35	PINK1	0.32338993
36	PRKCG	0.27241345
37	PAK1	0.27111336
38	EEF2K	0.27107442
39	STK38L	0.25741545
40	TESK2	0.24520227
41	PKN1	0.21737933
42	ATM	0.21357232
43	PAK2	0.20980453
44	MARK2	0.19540397
45	MARK1	0.15872530
46	CAMKK1	0.15208988
47	NEK6	0.14425467
48	CDK15	0.14227669
49	MAPKAPK5	0.14040999
50	PRKCZ	0.13602361
51	YES1	0.13547069
52	MAP3K10	0.12768975
53	WEE1	0.12657293
54	PRKAA1	0.12580465
55	MTOR	0.12386124
56	ATR	0.12285336
57	PRKG2	0.12049835
58	CDK18	0.11877041
59	CDK12	0.11140683
60	CDK11A	0.10886426
61	PRKG1	0.10143361
62	CDC7	0.09479294
63	RPS6KB1	0.08967464
64	CDK14	0.08108007
65	PLK1	0.08092134
66	BRSK2	0.07725513
67	MARK3	0.07706920
68	PRKCQ	0.07457903
69	WNK3	0.07423604
70	PRKACG	0.06968456
71	CSNK2A1	0.05195115
72	MAP3K5	0.04379078
73	GSK3B	0.04356609
74	CAMK2A	0.03838798
75	CSNK2A2	0.03419406
76	PAK6	0.03039996
77	PRKACB	0.03011267
78	PRKCB	0.03009377
79	CSNK1D	0.02612054
80	STK11	0.02320075
81	GSK3A	0.01986749
82	RPS6KA1	0.01866484
83	MAPK8	0.00666141
84	CDK1	0.00456338
85	CDK2	0.00314667
86	PAK4	0.00157072
87	PRKACA	0.00082933
88	MAP2K7	-0.0251034
89	EPHB1	-0.0249385
90	CAMK1	-0.0240045
91	MINK1	-0.0192735
92	MAPK4	-0.0188754
93	MAPK10	-0.0185293
94	BMPR1B	-0.0143753
95	DYRK2	-0.0078675
96	PRKCD	-0.0076118
97	CDK6	-0.0066334
98	RPS6KA3	-0.0063592
99	PRKCA	-0.0022610
100	EGFR	-0.0007551

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	4.58862848
2	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.18517880
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.77678810
4	Pyruvate metabolism_Homo sapiens_hsa00620	3.74365747
5	Propanoate metabolism_Homo sapiens_hsa00640	2.86274492
6	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.76697720
7	Glucagon signaling pathway_Homo sapiens_hsa04922	2.65870185
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.63634797
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.60646346
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.57215375
11	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.55373434
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.17322098
13	Basal transcription factors_Homo sapiens_hsa03022	2.11226380
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.07141525
15	Oocyte meiosis_Homo sapiens_hsa04114	1.88339442
16	Glycerolipid metabolism_Homo sapiens_hsa00561	1.87543188
17	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.76772934
18	PPAR signaling pathway_Homo sapiens_hsa03320	1.75738176
19	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.74408489
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.64538499
21	Mineral absorption_Homo sapiens_hsa04978	1.55436291
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.53953208
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46574557
24	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.46235266
25	Carbon metabolism_Homo sapiens_hsa01200	1.45165143
26	Amphetamine addiction_Homo sapiens_hsa05031	1.43677518
27	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.39943738
28	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.39704863
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.26953928
30	Huntingtons disease_Homo sapiens_hsa05016	1.25239500
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.24474629
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.23976585
33	Fat digestion and absorption_Homo sapiens_hsa04975	1.23677772
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23656059
35	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.23142427
36	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.22131959
37	Renin secretion_Homo sapiens_hsa04924	1.15993033
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15682461
39	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.09196219
40	Fatty acid degradation_Homo sapiens_hsa00071	1.08651841
41	Purine metabolism_Homo sapiens_hsa00230	1.08164427
42	Fatty acid metabolism_Homo sapiens_hsa01212	1.05474763
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04950785
44	Glutathione metabolism_Homo sapiens_hsa00480	1.03414385
45	Antigen processing and presentation_Homo sapiens_hsa04612	1.01011796
46	Bile secretion_Homo sapiens_hsa04976	0.92963567
47	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.91616202
48	Insulin secretion_Homo sapiens_hsa04911	0.88673449
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88356967
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.87269867
51	mRNA surveillance pathway_Homo sapiens_hsa03015	0.79617509
52	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.76753727
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.74100924
54	Sulfur metabolism_Homo sapiens_hsa00920	0.71180822
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.71075593
56	Estrogen signaling pathway_Homo sapiens_hsa04915	0.68469032
57	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66464711
58	Calcium signaling pathway_Homo sapiens_hsa04020	0.66272976
59	Long-term potentiation_Homo sapiens_hsa04720	0.64725957
60	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.62024212
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.61654112
62	RNA transport_Homo sapiens_hsa03013	0.61606827
63	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.60879932
64	Salivary secretion_Homo sapiens_hsa04970	0.60707323
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.59377958
66	Protein digestion and absorption_Homo sapiens_hsa04974	0.58452827
67	Gastric acid secretion_Homo sapiens_hsa04971	0.57916083
68	Pancreatic secretion_Homo sapiens_hsa04972	0.57447712
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.57263047
70	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56475086
71	Taste transduction_Homo sapiens_hsa04742	0.55221960
72	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.55104261
73	Renin-angiotensin system_Homo sapiens_hsa04614	0.54900120
74	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.54795518
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.51724014
76	Circadian entrainment_Homo sapiens_hsa04713	0.51324691
77	Legionellosis_Homo sapiens_hsa05134	0.48555659
78	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.48187617
79	Metabolic pathways_Homo sapiens_hsa01100	0.46192996
80	ABC transporters_Homo sapiens_hsa02010	0.44718947
81	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43574491
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.42187583
83	AMPK signaling pathway_Homo sapiens_hsa04152	0.32133550
84	Endocytosis_Homo sapiens_hsa04144	0.29952125
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29498258
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.28746264
87	VEGF signaling pathway_Homo sapiens_hsa04370	0.24709114
88	Alcoholism_Homo sapiens_hsa05034	0.22630090
89	Pyrimidine metabolism_Homo sapiens_hsa00240	0.22111854
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.17458399
91	Cocaine addiction_Homo sapiens_hsa05030	0.16814539
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.14446089
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.10383429
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.09871726
95	Retinol metabolism_Homo sapiens_hsa00830	0.09395975
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.08434021
97	Vibrio cholerae infection_Homo sapiens_hsa05110	0.07547410
98	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.06254735
99	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.05203556
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.03424597

IZUMO3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »