IZUMO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.76819106
2cilium or flagellum-dependent cell motility (GO:0001539)5.64487676
3acrosome reaction (GO:0007340)5.51846167
4B cell receptor signaling pathway (GO:0050853)5.50860713
5fusion of sperm to egg plasma membrane (GO:0007342)5.20106049
6CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.05417120
7acrosome assembly (GO:0001675)4.86227100
8cell wall macromolecule catabolic process (GO:0016998)4.81217531
9cell wall macromolecule metabolic process (GO:0044036)4.81217531
10positive regulation of gamma-delta T cell activation (GO:0046645)4.73400240
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.45693730
12positive thymic T cell selection (GO:0045059)4.42438725
13regulation of B cell receptor signaling pathway (GO:0050855)4.40733971
14multicellular organism reproduction (GO:0032504)4.38925660
15B cell homeostasis (GO:0001782)4.30712125
16mannose metabolic process (GO:0006013)4.29085717
17negative regulation of erythrocyte differentiation (GO:0045647)4.24102876
18sperm-egg recognition (GO:0035036)4.21269050
19plasma membrane fusion (GO:0045026)4.15999085
20epithelial cilium movement (GO:0003351)4.13699740
21axonemal dynein complex assembly (GO:0070286)4.12598924
22regulation of interferon-beta biosynthetic process (GO:0045357)4.10895835
23sequestering of actin monomers (GO:0042989)4.07916658
24calcium ion-dependent exocytosis (GO:0017156)4.07507292
25thymic T cell selection (GO:0045061)4.06305059
26sperm capacitation (GO:0048240)4.01721538
27activation of MAPKKK activity (GO:0000185)4.01559424
28germinal center formation (GO:0002467)4.00201391
29T cell migration (GO:0072678)3.97690940
30NIK/NF-kappaB signaling (GO:0038061)3.96739757
31response to muramyl dipeptide (GO:0032495)3.96420668
32cell-cell recognition (GO:0009988)3.91278685
33reproduction (GO:0000003)3.91214396
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.90462500
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.88416089
36response to type I interferon (GO:0034340)3.77529876
37regulation of histone H3-K27 methylation (GO:0061085)3.76704179
38cellular response to type I interferon (GO:0071357)3.76679668
39type I interferon signaling pathway (GO:0060337)3.76679668
40cilium movement (GO:0003341)3.70751401
41positive regulation of B cell differentiation (GO:0045579)3.67738768
42regulation of gamma-delta T cell activation (GO:0046643)3.64733605
43negative regulation of inclusion body assembly (GO:0090084)3.63692455
44positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62993853
45regulation of cilium movement (GO:0003352)3.57480814
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57478831
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.57478831
48modulation by symbiont of host immune response (GO:0052553)3.57478831
49positive regulation by symbiont of host defense response (GO:0052509)3.57478831
50modulation by symbiont of host defense response (GO:0052031)3.57478831
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57478831
52spermatid development (GO:0007286)3.53653847
53binding of sperm to zona pellucida (GO:0007339)3.51699276
54positive regulation of protein homooligomerization (GO:0032464)3.50981420
55protein localization to cilium (GO:0061512)3.46049325
56motile cilium assembly (GO:0044458)3.44666510
57synaptic vesicle maturation (GO:0016188)3.42089261
58interferon-gamma-mediated signaling pathway (GO:0060333)3.34647591
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33775183
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.33554607
61negative regulation of cell killing (GO:0031342)3.33554607
62macrophage activation involved in immune response (GO:0002281)3.32567679
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32305419
64T cell lineage commitment (GO:0002360)3.31014391
65organic cation transport (GO:0015695)3.30259815
66positive T cell selection (GO:0043368)3.29008759
67glutamate secretion (GO:0014047)3.27638443
68regulation of ARF GTPase activity (GO:0032312)3.27270034
69regulation of B cell differentiation (GO:0045577)3.26345275
70T cell selection (GO:0045058)3.25612978
71regulation of inclusion body assembly (GO:0090083)3.24252439
72regulation of type I interferon-mediated signaling pathway (GO:0060338)3.22410474
73immunoglobulin mediated immune response (GO:0016064)3.19081781
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.18207003
75synaptic vesicle exocytosis (GO:0016079)3.17928703
76regulation of short-term neuronal synaptic plasticity (GO:0048172)3.16295505
77modulation by symbiont of host cellular process (GO:0044068)3.15520996
78regulation of gamma-delta T cell differentiation (GO:0045586)3.14172076
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12905863
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12862322
81positive regulation of interferon-alpha production (GO:0032727)3.12615549
82regulation of T-helper 2 cell differentiation (GO:0045628)3.07667675
83modulation by virus of host process (GO:0019054)3.04822804
84chromosome condensation (GO:0030261)3.04454979
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01767110
86single fertilization (GO:0007338)3.00671082
87detection of bacterium (GO:0016045)2.97589919
88negative regulation of toll-like receptor signaling pathway (GO:0034122)2.97461626
89mature B cell differentiation (GO:0002335)2.96828473
90mature B cell differentiation involved in immune response (GO:0002313)2.94573896
91phosphatidylethanolamine biosynthetic process (GO:0006646)2.93554037
92peroxisome fission (GO:0016559)2.92387625
93negative regulation of protein oligomerization (GO:0032460)2.92067267
94regulation of synaptic vesicle exocytosis (GO:2000300)2.91379927
95regulation of beta-amyloid formation (GO:1902003)2.90836723
96regulation of amyloid precursor protein catabolic process (GO:1902991)2.90598645
97regulation of interferon-alpha production (GO:0032647)2.87182093
98lymphocyte homeostasis (GO:0002260)2.86993179
99positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.85134759
100cellular response to virus (GO:0098586)2.84118767
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83938182
102positive regulation of B cell proliferation (GO:0030890)2.82909023
103myeloid dendritic cell differentiation (GO:0043011)2.82313092
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81165663
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81165663
106positive regulation of Rap GTPase activity (GO:0032854)2.81060567
107membrane depolarization during action potential (GO:0086010)2.80824979
108synaptic vesicle docking involved in exocytosis (GO:0016081)2.80197113
109primary amino compound metabolic process (GO:1901160)2.79251458
110regulation of B cell proliferation (GO:0030888)2.78766085
111mucosal-associated lymphoid tissue development (GO:0048537)2.78712815
112Peyers patch development (GO:0048541)2.78712815
113regulation of synaptic vesicle transport (GO:1902803)2.78045109
114defense response to protozoan (GO:0042832)2.77829901
115positive regulation of myotube differentiation (GO:0010831)2.77279442
116leukocyte aggregation (GO:0070486)2.76409448
117lactate metabolic process (GO:0006089)2.75806034
118regulation of oxidative phosphorylation (GO:0002082)2.74658002
119detection of other organism (GO:0098543)2.74501133
120antigen processing and presentation of endogenous antigen (GO:0019883)2.74210087
121negative regulation of granulocyte differentiation (GO:0030853)2.73789870
122neurotransmitter secretion (GO:0007269)2.73721452
123histone H3 deacetylation (GO:0070932)2.73678060
124DNA packaging (GO:0006323)2.73663535
125histone H4 deacetylation (GO:0070933)2.73052453
126negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.72839860
127regulation of interferon-gamma biosynthetic process (GO:0045072)2.72821226
128regulation of interleukin-2 biosynthetic process (GO:0045076)2.72106730
129lymphocyte migration (GO:0072676)2.70534092
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70143374
131neuronal action potential propagation (GO:0019227)2.69527646
132neuromuscular process controlling posture (GO:0050884)2.68910504
133positive regulation of B cell activation (GO:0050871)2.68540053
134phosphatidylethanolamine metabolic process (GO:0046337)2.68193145
135B cell proliferation (GO:0042100)2.66588320
136antigen receptor-mediated signaling pathway (GO:0050851)2.66047614
137regulation of chromatin binding (GO:0035561)2.65790951
138natural killer cell differentiation (GO:0001779)2.64679335
139response to peptidoglycan (GO:0032494)2.64082035
140myeloid dendritic cell activation (GO:0001773)2.62864510
141activation of JUN kinase activity (GO:0007257)2.62827917
142response to protozoan (GO:0001562)2.61871856
143histone H3-K36 demethylation (GO:0070544)2.60782662
144piRNA metabolic process (GO:0034587)2.60466879
145cerebellar Purkinje cell differentiation (GO:0021702)2.60353443
146serotonin metabolic process (GO:0042428)2.58759859
147cellular response to arsenic-containing substance (GO:0071243)2.58201483
148cellular potassium ion homeostasis (GO:0030007)2.56756790
149negative thymic T cell selection (GO:0045060)2.55434222
150locomotory exploration behavior (GO:0035641)2.51566914
151negative T cell selection (GO:0043383)2.51382667
152protein localization to synapse (GO:0035418)2.47601245
153synaptonemal complex organization (GO:0070193)2.42395817
154proline transport (GO:0015824)2.42281122
155regulation of microtubule-based movement (GO:0060632)2.42013582
156sodium ion export (GO:0071436)2.41819581
157male meiosis (GO:0007140)2.40942485
158regulation of vesicle fusion (GO:0031338)2.39790810
159negative regulation of dendrite morphogenesis (GO:0050774)2.38448887
160positive regulation of cellular amide metabolic process (GO:0034250)2.35192788
161energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.34960621
162ATP hydrolysis coupled proton transport (GO:0015991)2.34960621
163regulation of ARF protein signal transduction (GO:0032012)2.32210089
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.31533714
165microtubule severing (GO:0051013)2.29580033
166oxygen transport (GO:0015671)2.27550782
167positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.27383320
168prepulse inhibition (GO:0060134)2.27028240
169neurotransmitter transport (GO:0006836)2.26738844
170regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26448807
171erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.26400183
172L-phenylalanine catabolic process (GO:0006559)2.26400183
173fertilization (GO:0009566)2.25373434
174sexual reproduction (GO:0019953)2.24224976
175nucleoside diphosphate catabolic process (GO:0009134)2.24138368
176activation of protein kinase A activity (GO:0034199)2.23905975
177positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.22884539
178ventricular system development (GO:0021591)2.22576379
179regulation of isotype switching to IgG isotypes (GO:0048302)2.22278572
180alpha-linolenic acid metabolic process (GO:0036109)2.20773061
181regulation of cellular amide metabolic process (GO:0034248)2.18941616
182cholesterol catabolic process (GO:0006707)2.15777018
183sterol catabolic process (GO:0016127)2.15777018
184neurotransmitter-gated ion channel clustering (GO:0072578)2.13372827
185spermatogenesis (GO:0007283)2.13094918
186response to pheromone (GO:0019236)2.12461428
187regulation of protein kinase A signaling (GO:0010738)2.12121871
188fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.12107669
189sodium ion homeostasis (GO:0055078)2.12088635
190protein polyglutamylation (GO:0018095)2.11966612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22765738
2MYC_22102868_ChIP-Seq_BL_Human4.13588774
3VDR_21846776_ChIP-Seq_THP-1_Human3.60625595
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19104458
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.77873349
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.70929151
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64005412
8TCF7_22412390_ChIP-Seq_EML_Mouse2.42119579
9KDM2B_26808549_Chip-Seq_DND41_Human2.40358034
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38001955
11MAF_26560356_Chip-Seq_TH1_Human2.36818878
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28961589
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.28584813
14MAF_26560356_Chip-Seq_TH2_Human2.26898459
15VDR_24763502_ChIP-Seq_THP-1_Human2.24976007
16REST_21632747_ChIP-Seq_MESCs_Mouse2.17265359
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09473016
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08413134
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07048300
20P68_20966046_ChIP-Seq_HELA_Human2.06338901
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05702862
22UTX_26944678_Chip-Seq_JUKART_Human2.05370215
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02309197
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00184274
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00179152
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97977653
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.85783049
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81703274
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78054998
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74606286
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72010298
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.70644731
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70228779
34DROSHA_22980978_ChIP-Seq_HELA_Human1.70163723
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70037145
36SA1_27219007_Chip-Seq_ERYTHROID_Human1.65859625
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64846550
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60229602
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.59583097
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56978595
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.56070432
42CIITA_25753668_ChIP-Seq_RAJI_Human1.55145600
43RACK7_27058665_Chip-Seq_MCF-7_Human1.54474166
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.51451130
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50789898
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.50461497
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49133104
48MYB_26560356_Chip-Seq_TH1_Human1.47847556
49KDM2B_26808549_Chip-Seq_K562_Human1.47487922
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.47105143
51PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44297167
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42522724
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.41122169
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39500724
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.38948228
56SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38754366
57MYB_26560356_Chip-Seq_TH2_Human1.38429696
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36692053
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36258885
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34452563
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34303858
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32964199
63PHF8_20622854_ChIP-Seq_HELA_Human1.32771999
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32762979
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32130427
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32045573
67E2F1_20622854_ChIP-Seq_HELA_Human1.29113071
68RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28748137
69NCOR1_26117541_ChIP-Seq_K562_Human1.28283170
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28262534
71CREB1_26743006_Chip-Seq_LNCaP_Human1.27791175
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.27543893
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27281131
74SPI1_23127762_ChIP-Seq_K562_Human1.26564088
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26557302
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26528379
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26387160
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24468181
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24274034
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22822744
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21192569
82NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20951741
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19247392
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15981215
85* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15980329
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14925200
87RARA_24833708_ChIP-Seq_LIVER_Mouse1.14386536
88CTCF_21964334_Chip-Seq_Bcells_Human1.14377988
89SA1_27219007_Chip-Seq_Bcells_Human1.14184781
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13689773
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13548408
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13091211
93RUNX_20019798_ChIP-Seq_JUKART_Human1.12910399
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12507613
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12242998
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12224034
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.12023244
98SPI1_23547873_ChIP-Seq_NB4_Human1.11969787
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11881999
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11009213
101KDM2B_26808549_Chip-Seq_REH_Human1.10840133
102CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10766595
103SMAD4_21799915_ChIP-Seq_A2780_Human1.09916538
104P300_27268052_Chip-Seq_Bcells_Human1.09435924
105* TP63_22573176_ChIP-Seq_HFKS_Human1.09365408
106TAF15_26573619_Chip-Seq_HEK293_Human1.07633890
107ETS1_21867929_ChIP-Seq_TH2_Mouse1.07322190
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07230837
109IRF8_27001747_Chip-Seq_BMDM_Mouse1.07134806
110VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06395844
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06388946
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06038012
113RARB_24833708_ChIP-Seq_LIVER_Mouse1.05767699
114SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05723874
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05334544
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04892469
117CBP_20019798_ChIP-Seq_JUKART_Human1.04892469
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04266187
119GBX2_23144817_ChIP-Seq_PC3_Human1.04204565
120DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04012249
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98803415
122RNF2_27304074_Chip-Seq_ESCs_Mouse0.97117815
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96643050
124ELF1_20517297_ChIP-Seq_JURKAT_Human0.96168167
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95906744
126EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95517656
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95517656
128ZNF274_21170338_ChIP-Seq_K562_Hela0.95145374
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94427246
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93183669
131AR_25329375_ChIP-Seq_VCAP_Human0.93088952
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92910961
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90877768
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90771322
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90309049
136RXR_22158963_ChIP-Seq_LIVER_Mouse0.90128356
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88965737
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88512965
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88277001
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87631407
141FLI1_21867929_ChIP-Seq_TH2_Mouse0.86815357
142RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86715270
143BCL6_27268052_Chip-Seq_Bcells_Human0.84602608
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83770338
145LXR_22292898_ChIP-Seq_THP-1_Human0.83104047
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83091725
147CTCF_27219007_Chip-Seq_Bcells_Human0.82311191
148MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81680691
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81669205
150ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81278296
151MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80352732
152GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.80286106
153MYC_27129775_Chip-Seq_CORNEA_Mouse0.79972891
154LXR_22158963_ChIP-Seq_LIVER_Mouse0.78934003
155CTCF_20526341_ChIP-Seq_ESCs_Human0.76627466
156SMC4_20622854_ChIP-Seq_HELA_Human0.76489660
157STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75879852
158FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75416644
159SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75321609
160GATA1_26923725_Chip-Seq_HPCs_Mouse0.74429808
161P53_21459846_ChIP-Seq_SAOS-2_Human0.74186441
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74110632
163EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.73845928
164SMAD3_21741376_ChIP-Seq_ESCs_Human0.73809452
165GATA3_21867929_ChIP-Seq_TH1_Mouse0.73110882
166TET1_21490601_ChIP-Seq_MESCs_Mouse0.72573088
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72420008
168NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.72240848
169FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71338389
170BCOR_27268052_Chip-Seq_Bcells_Human0.71013413
171PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70905591
172FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70739162
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.70278722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.79508221
2MP0003303_peritoneal_inflammation3.44339394
3MP0004859_abnormal_synaptic_plasticity3.30869766
4MP0003436_decreased_susceptibility_to3.16293515
5MP0002822_catalepsy3.01638656
6MP0002452_abnormal_antigen_presenting2.53190823
7MP0003329_amyloid_beta_deposits2.42610385
8MP0001968_abnormal_touch/_nociception2.40592612
9MP0002735_abnormal_chemical_nociception2.40524437
10MP0002420_abnormal_adaptive_immunity2.34789904
11MP0001819_abnormal_immune_cell2.30764622
12MP0003635_abnormal_synaptic_transmissio2.28509153
13MP0002398_abnormal_bone_marrow2.24954435
14MP0009046_muscle_twitch2.20139754
15MP0003183_abnormal_peptide_metabolism2.16660407
16MP0005025_abnormal_response_to2.15957653
17MP0009745_abnormal_behavioral_response2.07913434
18MP0005451_abnormal_body_composition2.05369506
19MP0000716_abnormal_immune_system2.04524254
20MP0002736_abnormal_nociception_after2.02695587
21MP0006276_abnormal_autonomic_nervous1.99065903
22MP0002064_seizures1.95004180
23MP0010386_abnormal_urinary_bladder1.92715416
24MP0004947_skin_inflammation1.81959901
25MP0003698_abnormal_male_reproductive1.81697936
26MP0002733_abnormal_thermal_nociception1.80554170
27MP0003880_abnormal_central_pattern1.78859109
28MP0004858_abnormal_nervous_system1.78037172
29MP0003172_abnormal_lysosome_physiology1.76831581
30MP0002419_abnormal_innate_immunity1.76055864
31MP0005083_abnormal_biliary_tract1.74829417
32MP0002163_abnormal_gland_morphology1.74684369
33MP0000604_amyloidosis1.72934171
34MP0001970_abnormal_pain_threshold1.72334023
35MP0009333_abnormal_splenocyte_physiolog1.72174618
36MP0001984_abnormal_olfaction1.71212494
37MP0002572_abnormal_emotion/affect_behav1.70381634
38MP0001348_abnormal_lacrimal_gland1.70099788
39MP0002405_respiratory_system_inflammati1.69550975
40MP0002063_abnormal_learning/memory/cond1.69286444
41MP0004270_analgesia1.69272677
42MP0002429_abnormal_blood_cell1.66648511
43MP0001986_abnormal_taste_sensitivity1.63232523
44MP0008872_abnormal_physiological_respon1.63153508
45MP0000689_abnormal_spleen_morphology1.61835737
46MP0000685_abnormal_immune_system1.61380061
47MP0002272_abnormal_nervous_system1.60989907
48MP0008260_abnormal_autophagy1.60866783
49MP0002722_abnormal_immune_system1.59182821
50MP0002139_abnormal_hepatobiliary_system1.59153176
51MP0000703_abnormal_thymus_morphology1.57821371
52MP0002396_abnormal_hematopoietic_system1.55634986
53MP0005645_abnormal_hypothalamus_physiol1.53487461
54MP0001873_stomach_inflammation1.52709981
55MP0001835_abnormal_antigen_presentation1.52555921
56MP0008569_lethality_at_weaning1.52033249
57MP0003879_abnormal_hair_cell1.50729658
58MP0005646_abnormal_pituitary_gland1.49393618
59MP0002909_abnormal_adrenal_gland1.49047623
60MP0002734_abnormal_mechanical_nocicepti1.47856480
61MP0005365_abnormal_bile_salt1.47665626
62MP0001501_abnormal_sleep_pattern1.47362867
63MP0003300_gastrointestinal_ulcer1.43757575
64MP0001845_abnormal_inflammatory_respons1.42948906
65MP0010155_abnormal_intestine_physiology1.38925618
66MP0001905_abnormal_dopamine_level1.38166084
67MP0005058_abnormal_lysosome_morphology1.35884430
68MP0005379_endocrine/exocrine_gland_phen1.35608408
69MP0001502_abnormal_circadian_rhythm1.32621223
70MP0001929_abnormal_gametogenesis1.28870202
71MP0003633_abnormal_nervous_system1.28275205
72MP0003091_abnormal_cell_migration1.27414898
73MP0002166_altered_tumor_susceptibility1.27083232
74MP0002067_abnormal_sensory_capabilities1.23592892
75MP0005535_abnormal_body_temperature1.22733936
76MP0002876_abnormal_thyroid_physiology1.22500425
77MP0009278_abnormal_bone_marrow1.21517011
78MP0002933_joint_inflammation1.21224575
79MP0001765_abnormal_ion_homeostasis1.20896780
80MP0008875_abnormal_xenobiotic_pharmacok1.20793800
81MP0001440_abnormal_grooming_behavior1.19736144
82MP0009780_abnormal_chondrocyte_physiolo1.19310809
83MP0005085_abnormal_gallbladder_physiolo1.18244385
84MP0001853_heart_inflammation1.18135527
85MP0005671_abnormal_response_to1.14952486
86MP0005670_abnormal_white_adipose1.13791449
87MP0002638_abnormal_pupillary_reflex1.12895181
88MP0001790_abnormal_immune_system1.11882269
89MP0005387_immune_system_phenotype1.11882269
90MP0008874_decreased_physiological_sensi1.09742592
91MP0005666_abnormal_adipose_tissue1.07032052
92MP0004381_abnormal_hair_follicle1.06285735
93MP0005423_abnormal_somatic_nervous1.06273435
94MP0004510_myositis1.04150438
95MP0003763_abnormal_thymus_physiology1.03541240
96MP0002557_abnormal_social/conspecific_i1.02324377
97MP0000678_abnormal_parathyroid_gland1.02006987
98MP0002653_abnormal_ependyma_morphology1.01974675
99MP0005360_urolithiasis1.01763948
100MP0005636_abnormal_mineral_homeostasis1.01698142
101MP0002928_abnormal_bile_duct1.00437457
102MP0005310_abnormal_salivary_gland0.99878657
103MP0000003_abnormal_adipose_tissue0.99588945
104MP0004808_abnormal_hematopoietic_stem0.99553055
105MP0005584_abnormal_enzyme/coenzyme_acti0.98497910
106MP0010329_abnormal_lipoprotein_level0.98193676
107MP0003631_nervous_system_phenotype0.97733889
108MP0004811_abnormal_neuron_physiology0.97668003
109MP0005375_adipose_tissue_phenotype0.96532433
110MP0001486_abnormal_startle_reflex0.96010493
111MP0003866_abnormal_defecation0.95333372
112MP0008961_abnormal_basal_metabolism0.93284367
113MP0001533_abnormal_skeleton_physiology0.92391382
114MP0002148_abnormal_hypersensitivity_rea0.92330745
115MP0002184_abnormal_innervation0.91979992
116MP0008469_abnormal_protein_level0.91769290
117MP0003453_abnormal_keratinocyte_physiol0.91565964
118MP0003075_altered_response_to0.91341136
119MP0002132_abnormal_respiratory_system0.91247913
120MP0004924_abnormal_behavior0.88451494
121MP0005386_behavior/neurological_phenoty0.88451494
122MP0002998_abnormal_bone_remodeling0.86268135
123MP0002254_reproductive_system_inflammat0.85863977
124MP0000013_abnormal_adipose_tissue0.84567930
125MP0002138_abnormal_hepatobiliary_system0.83272944
126MP0009840_abnormal_foam_cell0.82919833
127MP0005332_abnormal_amino_acid0.82507389
128MP0005377_hearing/vestibular/ear_phenot0.82393024
129MP0003878_abnormal_ear_physiology0.82393024
130MP0003868_abnormal_feces_composition0.81783279
131MP0002161_abnormal_fertility/fecundity0.81407330
132MP0005000_abnormal_immune_tolerance0.81325619
133MP0009785_altered_susceptibility_to0.81074367
134MP0001800_abnormal_humoral_immune0.80226009
135MP0002066_abnormal_motor_capabilities/c0.79597321
136MP0001756_abnormal_urination0.78405770
137MP0002019_abnormal_tumor_incidence0.77035029
138MP0005464_abnormal_platelet_physiology0.76807469
139MP0002118_abnormal_lipid_homeostasis0.76069007
140MP0001346_abnormal_lacrimal_gland0.75153943
141MP0002723_abnormal_immune_serum0.75056063
142MP0005166_decreased_susceptibility_to0.73391513
143MP0001664_abnormal_digestion0.73233264
144MP0002693_abnormal_pancreas_physiology0.72743100
145MP0002006_tumorigenesis0.72610253
146MP0005076_abnormal_cell_differentiation0.72533952
147MP0004142_abnormal_muscle_tone0.72453775
148MP0000955_abnormal_spinal_cord0.72075863
149MP0000609_abnormal_liver_physiology0.69480943
150MP0000858_altered_metastatic_potential0.69312852
151MP0005397_hematopoietic_system_phenotyp0.67618177
152MP0001545_abnormal_hematopoietic_system0.67618177
153MP0005167_abnormal_blood-brain_barrier0.66702023
154MP0003045_fibrosis0.65833359
155MP0002136_abnormal_kidney_physiology0.65091179
156MP0005409_darkened_coat_color0.62775383
157MP0000249_abnormal_blood_vessel0.62622167
158MP0000313_abnormal_cell_death0.61735817
159MP0003191_abnormal_cellular_cholesterol0.58462666
160MP0001849_ear_inflammation0.57098871
161MP0003705_abnormal_hypodermis_morpholog0.54526813
162MP0009115_abnormal_fat_cell0.54263697

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.21966611
2Gastrointestinal stroma tumor (HP:0100723)6.19972605
3Absent/shortened dynein arms (HP:0200106)6.16064295
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.16064295
5Chronic bronchitis (HP:0004469)5.34080385
6Nasal polyposis (HP:0100582)5.15224711
7Agammaglobulinemia (HP:0004432)4.83602533
8Abnormal respiratory motile cilium physiology (HP:0012261)4.72736993
9Colitis (HP:0002583)4.63225566
10Myokymia (HP:0002411)4.49148015
11Rhinitis (HP:0012384)4.25721463
12Abnormality of the nasal mucosa (HP:0000433)4.25485908
13Emphysema (HP:0002097)4.24946511
14Abnormal respiratory epithelium morphology (HP:0012253)4.09636392
15Abnormal respiratory motile cilium morphology (HP:0005938)4.09636392
16Meningitis (HP:0001287)4.00349958
17Cellulitis (HP:0100658)3.97050579
18Bronchitis (HP:0012387)3.90585820
19Abnormal ciliary motility (HP:0012262)3.85720590
20Hypothermia (HP:0002045)3.71833392
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.67366420
22Infertility (HP:0000789)3.63439494
23Mediastinal lymphadenopathy (HP:0100721)3.63171512
24Gastrointestinal inflammation (HP:0004386)3.62794672
25Lymphopenia (HP:0001888)3.55349948
26Inflammation of the large intestine (HP:0002037)3.52989404
27Bronchiectasis (HP:0002110)3.46624069
28Vasculitis (HP:0002633)3.36818874
29Abnormality of cells of the lymphoid lineage (HP:0012140)3.29926687
30IgM deficiency (HP:0002850)3.26060257
31Recurrent viral infections (HP:0004429)3.22776905
32IgA deficiency (HP:0002720)3.20143083
33Panhypogammaglobulinemia (HP:0003139)3.13799032
34Recurrent pneumonia (HP:0006532)3.13204755
35Eczematoid dermatitis (HP:0000976)3.11331821
36Increased IgE level (HP:0003212)3.10950057
37Recurrent bronchitis (HP:0002837)2.94922778
38Restrictive lung disease (HP:0002091)2.94015392
39Recurrent lower respiratory tract infections (HP:0002783)2.93392084
40Obstructive lung disease (HP:0006536)2.87372365
41Chronic obstructive pulmonary disease (HP:0006510)2.87372365
42Abnormal gallbladder physiology (HP:0012438)2.84076427
43Cholecystitis (HP:0001082)2.84076427
44Hypertensive crisis (HP:0100735)2.82043465
45Supranuclear gaze palsy (HP:0000605)2.80720268
46Papilloma (HP:0012740)2.78629354
47Verrucae (HP:0200043)2.78629354
48Gastrointestinal infarctions (HP:0005244)2.75591387
49Annular pancreas (HP:0001734)2.69038242
50Recurrent fungal infections (HP:0002841)2.69012607
51Hypokalemic alkalosis (HP:0001949)2.66964402
52Basal cell carcinoma (HP:0002671)2.64236279
53Visual hallucinations (HP:0002367)2.62800758
54Neuroendocrine neoplasm (HP:0100634)2.60197321
55Focal motor seizures (HP:0011153)2.58962610
56Progressive cerebellar ataxia (HP:0002073)2.57839048
57Hypoplasia of the thymus (HP:0000778)2.57580042
58Recurrent bacterial skin infections (HP:0005406)2.57140299
59Slow saccadic eye movements (HP:0000514)2.52769789
60Asymmetric septal hypertrophy (HP:0001670)2.49685858
61Abnormality of the lower motor neuron (HP:0002366)2.48455044
62Recurrent cutaneous fungal infections (HP:0011370)2.48337237
63Chronic mucocutaneous candidiasis (HP:0002728)2.48337237
64Abnormality of the fingertips (HP:0001211)2.48142926
65Pheochromocytoma (HP:0002666)2.47985893
66Abnormality of T cell physiology (HP:0011840)2.47428530
67Neurofibrillary tangles (HP:0002185)2.46799150
68Squamous cell carcinoma (HP:0002860)2.45237125
69Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45228342
70Chronic sinusitis (HP:0011109)2.44511726
71Recurrent abscess formation (HP:0002722)2.42284256
72Abnormality of macrophages (HP:0004311)2.41232720
73Epileptic encephalopathy (HP:0200134)2.39876241
74Decreased circulating renin level (HP:0003351)2.37951171
75Focal seizures (HP:0007359)2.35996699
76Hyperactive renin-angiotensin system (HP:0000841)2.35317151
77Truncal ataxia (HP:0002078)2.35041516
78Hypercortisolism (HP:0001578)2.33673931
79Severe visual impairment (HP:0001141)2.30174936
80Thin bony cortex (HP:0002753)2.28056719
81Retinal dysplasia (HP:0007973)2.25511096
82Recurrent sinusitis (HP:0011108)2.24949390
83Osteomyelitis (HP:0002754)2.23319233
84Chronic otitis media (HP:0000389)2.23158776
85Nephronophthisis (HP:0000090)2.22327759
86Deep palmar crease (HP:0006191)2.21850003
87Adrenal overactivity (HP:0002717)2.18337620
88Papilledema (HP:0001085)2.17805341
89Hyperacusis (HP:0010780)2.15688424
90Peripheral hypomyelination (HP:0007182)2.13899285
91Aplasia/Hypoplasia of the thymus (HP:0010515)2.13829957
92Recurrent otitis media (HP:0000403)2.13485356
93Recurrent skin infections (HP:0001581)2.12909615
94Gingivitis (HP:0000230)2.10802972
95Medial flaring of the eyebrow (HP:0010747)2.08388391
96Febrile seizures (HP:0002373)2.07565502
97Nuclear cataract (HP:0100018)2.07183121
98Failure to thrive in infancy (HP:0001531)2.05367081
99Depression (HP:0000716)2.05002994
100Pulmonary infiltrates (HP:0002113)2.04772018
101Male infertility (HP:0003251)2.04695986
102Ankle clonus (HP:0011448)2.03671157
103Hyperaldosteronism (HP:0000859)2.03001310
104Fatigue (HP:0012378)2.00633650
105IgG deficiency (HP:0004315)2.00576184
106Cerebral inclusion bodies (HP:0100314)1.98964659
107Flattened epiphyses (HP:0003071)1.98613436
108Impaired vibration sensation in the lower limbs (HP:0002166)1.98189064
109Alkalosis (HP:0001948)1.97533906
110Easy fatigability (HP:0003388)1.95956242
111Progressive inability to walk (HP:0002505)1.95757753
112Menstrual irregularities (HP:0000858)1.94813477
113Abnormality of the peritoneum (HP:0002585)1.94762412
114Recurrent gram-negative bacterial infections (HP:0005420)1.94052949
115J-shaped sella turcica (HP:0002680)1.93181775
116Hepatitis (HP:0012115)1.93001613
117Conjugated hyperbilirubinemia (HP:0002908)1.92533747
118Seborrheic dermatitis (HP:0001051)1.92491724
119Atonic seizures (HP:0010819)1.89788051
120Limb dystonia (HP:0002451)1.87081930
121Encephalitis (HP:0002383)1.85574540
122Abnormality of T cells (HP:0002843)1.85404499
123Leukopenia (HP:0001882)1.85056941
124Psychosis (HP:0000709)1.84047792
125Urinary urgency (HP:0000012)1.83992553
126Anxiety (HP:0000739)1.83253340
127Hyperkalemia (HP:0002153)1.82966214
128Abnormality of saccadic eye movements (HP:0000570)1.82610909
129Lymphoma (HP:0002665)1.81430006
130Pustule (HP:0200039)1.81128958
131Mitral stenosis (HP:0001718)1.80471151
132Hemorrhage of the eye (HP:0011885)1.80252265
133Nephrogenic diabetes insipidus (HP:0009806)1.80185006
134Resting tremor (HP:0002322)1.79364808
135Chest pain (HP:0100749)1.79003222
136Large eyes (HP:0001090)1.77109771
137Abnormality of the renal medulla (HP:0100957)1.76705618
138Gaze-evoked nystagmus (HP:0000640)1.74972126
139Sepsis (HP:0100806)1.74608632
140Cerebral hemorrhage (HP:0001342)1.74392601
141Abnormal eating behavior (HP:0100738)1.74382503
142Urticaria (HP:0001025)1.73922835
143Obstructive sleep apnea (HP:0002870)1.73701286
144Arthralgia (HP:0002829)1.73137698
145Action tremor (HP:0002345)1.72955004
146Viral hepatitis (HP:0006562)1.72666735
147Absence seizures (HP:0002121)1.72128494
148Abnormal hair whorl (HP:0010721)1.72104201
149Polyphagia (HP:0002591)1.71058452
150Urinary bladder sphincter dysfunction (HP:0002839)1.70821055
151Limb ataxia (HP:0002070)1.70792698
152Neuronal loss in central nervous system (HP:0002529)1.70672449
153Type II lissencephaly (HP:0007260)1.69447051
154Postural instability (HP:0002172)1.67521106
155Hypertriglyceridemia (HP:0002155)1.67375213
156Turricephaly (HP:0000262)1.67274604
157Global brain atrophy (HP:0002283)1.66892991
158Growth hormone excess (HP:0000845)1.66779904
159Segmental peripheral demyelination/remyelination (HP:0003481)1.66776280
160Megalencephaly (HP:0001355)1.65941016
161Premature loss of primary teeth (HP:0006323)1.65639191
162Spinal canal stenosis (HP:0003416)1.65413835
163Skin ulcer (HP:0200042)1.65174880
164Agitation (HP:0000713)1.64829535
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.64184558
166Increased IgM level (HP:0003496)1.63993379
167Focal dystonia (HP:0004373)1.63699813
168Myositis (HP:0100614)1.63336599
169Hyperphosphatemia (HP:0002905)1.62801955
170Craniofacial dystonia (HP:0012179)1.62787446
171Poikiloderma (HP:0001029)1.62636414
172Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62243887
173Vascular calcification (HP:0004934)1.61859712
174Abnormality of chloride homeostasis (HP:0011422)1.59005176
175Torticollis (HP:0000473)1.58603831
176Bradykinesia (HP:0002067)1.58311546
177Renal salt wasting (HP:0000127)1.57016794
178Spastic gait (HP:0002064)1.56953931
179Generalized tonic-clonic seizures (HP:0002069)1.56928830
180Gait imbalance (HP:0002141)1.56573306
181Hyperventilation (HP:0002883)1.56423286
182Poor suck (HP:0002033)1.56068045
183Abnormality of calcium-phosphate metabolism (HP:0100530)1.55873968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.29504424
2LMTK23.87784452
3PDK43.79963287
4PDK33.79963287
5MAP3K123.24049615
6TESK12.90656017
7NTRK32.75751136
8BLK2.65937475
9TRIB32.65376659
10PTK2B2.19195619
11GRK52.09332998
12PRKD32.06960689
13RIPK42.00387872
14PDK21.96839240
15MAP3K131.85362859
16SIK31.85297640
17MAP3K101.82414963
18SMG11.77050501
19IRAK41.74312461
20MAP3K91.73480756
21CDK121.69294040
22EEF2K1.64718228
23MAP2K71.62029927
24MAP2K31.58950618
25DAPK21.55587727
26KSR21.52132978
27MAP4K11.50872590
28SIK21.40523908
29NEK91.32262174
30SIK11.29638549
31MAP3K41.28786741
32MAP3K21.28717736
33DDR21.27746016
34ARAF1.25936031
35TYK21.24350616
36STK381.19845113
37MAP2K41.19746521
38MINK11.18122725
39NTRK21.17233253
40NTRK11.17000606
41WNK41.13920626
42MAPK121.13727777
43BCKDK1.13517520
44CDK191.12747472
45GRK71.11108243
46IKBKB1.10267688
47ZAP701.09687929
48MAP3K11.07824118
49PDK11.07289633
50FGFR41.06602971
51DAPK11.06220812
52RET1.04411479
53TBK11.02885526
54MAP3K141.01661899
55MAPK111.01368739
56BRAF1.01094708
57GRK61.00845555
58IRAK11.00680906
59JAK11.00251080
60SYK0.99616710
61MAPKAPK50.98929854
62BRD40.98387752
63JAK30.97528144
64TNK20.96627805
65PRKD20.94612855
66TAOK20.94222753
67CAMKK10.93330985
68WNK10.89144371
69PASK0.88151429
70CDK40.86155183
71IKBKE0.84098494
72MARK20.83026156
73LYN0.80666162
74NME20.80018630
75DYRK1B0.77764164
76UHMK10.77662420
77CDK50.77431130
78ICK0.77430696
79TAOK10.75793069
80CSK0.74792332
81PRKCH0.74536092
82MAPK150.73927133
83CASK0.73735097
84TXK0.73732649
85FES0.73521705
86MAP2K60.73376450
87MAP3K110.72968921
88PAK60.71202086
89BMPR1B0.70073097
90CDC42BPA0.69137284
91PINK10.68108573
92HCK0.68062724
93ADRBK10.66947473
94ERN10.66865973
95BMPR20.66645675
96FRK0.66464700
97RPS6KL10.66137544
98RPS6KC10.66137544
99FGFR30.65721892
100MAPK130.64399901
101BTK0.63743614
102STK390.63723350
103PRKCG0.63046514
104ADRBK20.62297509
105PIM20.61668829
106IRAK20.60942141
107MARK30.60754531
108SGK2230.60405576
109SGK4940.60405576
110PDPK10.60120101
111JAK20.59024736
112PKN20.58302819
113PLK40.58005863
114CHUK0.57294545
115ITK0.56632995
116TYRO30.55788094
117CAMKK20.55608635
118IRAK30.54598931
119PRKCQ0.54242687
120EPHA40.54161126
121TESK20.53158369
122RAF10.50622173
123SGK20.50371849
124MAP3K70.50098556
125EPHA30.49933809
126MAPK70.49891943
127FLT30.49482821
128MAPK40.48574311
129RPS6KA60.47528783
130KIT0.45856487
131FGR0.45373896
132MAP3K80.44097230
133LRRK20.43899849
134RPS6KA20.43528824
135LCK0.42841082
136PRKG20.42731680
137CAMK2A0.42454558
138CAMK1D0.42229548
139HIPK20.41667616
140MOS0.41517547
141MAP2K20.41430505
142MYLK0.40902343
143PHKG10.40774160
144PHKG20.40774160
145TEC0.40117672
146SGK30.39390677
147CAMK1G0.38891871
148MTOR0.38583537
149CSF1R0.37456176
150CAMK10.35207538
151TNIK0.35026619

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.15461566
2Autoimmune thyroid disease_Homo sapiens_hsa053202.73554748
3Graft-versus-host disease_Homo sapiens_hsa053322.52528988
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41151395
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26167732
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23552199
7Collecting duct acid secretion_Homo sapiens_hsa049662.19953316
8Leishmaniasis_Homo sapiens_hsa051402.10924550
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00088236
10Asthma_Homo sapiens_hsa053101.94279164
11Amphetamine addiction_Homo sapiens_hsa050311.90064695
12Insulin secretion_Homo sapiens_hsa049111.84628490
13Influenza A_Homo sapiens_hsa051641.82191947
14Acute myeloid leukemia_Homo sapiens_hsa052211.81552343
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80418629
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.79157950
17Other glycan degradation_Homo sapiens_hsa005111.78558555
18Viral myocarditis_Homo sapiens_hsa054161.76130234
19Osteoclast differentiation_Homo sapiens_hsa043801.69305993
20Circadian entrainment_Homo sapiens_hsa047131.68358950
21Olfactory transduction_Homo sapiens_hsa047401.68333744
22Taste transduction_Homo sapiens_hsa047421.66944464
23Nicotine addiction_Homo sapiens_hsa050331.65786553
24Measles_Homo sapiens_hsa051621.61015045
25Toxoplasmosis_Homo sapiens_hsa051451.59348251
26Herpes simplex infection_Homo sapiens_hsa051681.56412875
27Antigen processing and presentation_Homo sapiens_hsa046121.49527860
28Pyruvate metabolism_Homo sapiens_hsa006201.49031415
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48137673
30Morphine addiction_Homo sapiens_hsa050321.47945861
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47792877
32Cocaine addiction_Homo sapiens_hsa050301.47533321
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46677249
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44187177
35Renin secretion_Homo sapiens_hsa049241.42173992
36Salivary secretion_Homo sapiens_hsa049701.39738226
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.39656022
38Glutamatergic synapse_Homo sapiens_hsa047241.39528805
39GABAergic synapse_Homo sapiens_hsa047271.38411711
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38028874
41Long-term potentiation_Homo sapiens_hsa047201.37054086
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35812676
43Tuberculosis_Homo sapiens_hsa051521.35618609
44Non-small cell lung cancer_Homo sapiens_hsa052231.31528102
45Propanoate metabolism_Homo sapiens_hsa006401.25585146
46Hepatitis B_Homo sapiens_hsa051611.24804709
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23763757
48Dopaminergic synapse_Homo sapiens_hsa047281.22774250
49Epstein-Barr virus infection_Homo sapiens_hsa051691.22196343
50Vibrio cholerae infection_Homo sapiens_hsa051101.19078883
51Staphylococcus aureus infection_Homo sapiens_hsa051501.19017579
52Gastric acid secretion_Homo sapiens_hsa049711.17975091
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.17058083
54Cholinergic synapse_Homo sapiens_hsa047251.16492897
55Glycerolipid metabolism_Homo sapiens_hsa005611.16340907
56Pancreatic secretion_Homo sapiens_hsa049721.14685930
57Bile secretion_Homo sapiens_hsa049761.14443949
58Apoptosis_Homo sapiens_hsa042101.13138242
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09639455
60Chronic myeloid leukemia_Homo sapiens_hsa052201.08940044
61Hepatitis C_Homo sapiens_hsa051601.06542151
62Type I diabetes mellitus_Homo sapiens_hsa049401.05638670
63Primary immunodeficiency_Homo sapiens_hsa053401.04804325
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04773223
65Fatty acid biosynthesis_Homo sapiens_hsa000611.04034413
66Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02888694
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00789791
68Notch signaling pathway_Homo sapiens_hsa043300.98641741
69Glucagon signaling pathway_Homo sapiens_hsa049220.98538606
70Viral carcinogenesis_Homo sapiens_hsa052030.97698152
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96681954
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95896695
73TNF signaling pathway_Homo sapiens_hsa046680.95840674
74ABC transporters_Homo sapiens_hsa020100.92905603
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.89957793
76Type II diabetes mellitus_Homo sapiens_hsa049300.88211044
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88205334
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88110412
79HTLV-I infection_Homo sapiens_hsa051660.86739291
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86735970
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.86485501
82Fatty acid degradation_Homo sapiens_hsa000710.86427433
83mTOR signaling pathway_Homo sapiens_hsa041500.84675014
84Phenylalanine metabolism_Homo sapiens_hsa003600.83605071
85Calcium signaling pathway_Homo sapiens_hsa040200.82089492
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.81133521
87Pancreatic cancer_Homo sapiens_hsa052120.80496509
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79102344
89ErbB signaling pathway_Homo sapiens_hsa040120.78872125
90Rheumatoid arthritis_Homo sapiens_hsa053230.77915914
91MAPK signaling pathway_Homo sapiens_hsa040100.77332359
92Systemic lupus erythematosus_Homo sapiens_hsa053220.76553614
93HIF-1 signaling pathway_Homo sapiens_hsa040660.75508370
94Nitrogen metabolism_Homo sapiens_hsa009100.74832352
95Endometrial cancer_Homo sapiens_hsa052130.73862541
96Fatty acid metabolism_Homo sapiens_hsa012120.73264602
97Hematopoietic cell lineage_Homo sapiens_hsa046400.72575958
98cAMP signaling pathway_Homo sapiens_hsa040240.72124072
99Choline metabolism in cancer_Homo sapiens_hsa052310.71657947
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71628506
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.71033003
102Serotonergic synapse_Homo sapiens_hsa047260.71012920
103B cell receptor signaling pathway_Homo sapiens_hsa046620.70967519
104Cardiac muscle contraction_Homo sapiens_hsa042600.70809385
105Tryptophan metabolism_Homo sapiens_hsa003800.70565347
106Fructose and mannose metabolism_Homo sapiens_hsa000510.70446237
107PPAR signaling pathway_Homo sapiens_hsa033200.70264287
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70184232
109Oxidative phosphorylation_Homo sapiens_hsa001900.70175373
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69856427
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.69212510
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67801677
113Sulfur relay system_Homo sapiens_hsa041220.67224547
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66118559
115Glioma_Homo sapiens_hsa052140.65881858
116T cell receptor signaling pathway_Homo sapiens_hsa046600.65816822
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65110773
118Peroxisome_Homo sapiens_hsa041460.62818938
119Prostate cancer_Homo sapiens_hsa052150.61988270
120Parkinsons disease_Homo sapiens_hsa050120.61880031
121Thyroid hormone synthesis_Homo sapiens_hsa049180.61452238
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.61162528
123Allograft rejection_Homo sapiens_hsa053300.61044784
124Renal cell carcinoma_Homo sapiens_hsa052110.60560606
125Alzheimers disease_Homo sapiens_hsa050100.59885031
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59425738
127Insulin signaling pathway_Homo sapiens_hsa049100.59365072
128Arginine biosynthesis_Homo sapiens_hsa002200.57797000
129Estrogen signaling pathway_Homo sapiens_hsa049150.56635897
130Oxytocin signaling pathway_Homo sapiens_hsa049210.55278580
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54754032
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53665301
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.52423623
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50960042
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50947257
136Dorso-ventral axis formation_Homo sapiens_hsa043200.49812394
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48667408
138African trypanosomiasis_Homo sapiens_hsa051430.48345401
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48337681
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48314407
141Tyrosine metabolism_Homo sapiens_hsa003500.48120825
142Chemokine signaling pathway_Homo sapiens_hsa040620.47519231
143Inositol phosphate metabolism_Homo sapiens_hsa005620.46378811
144Colorectal cancer_Homo sapiens_hsa052100.45093423
145Bladder cancer_Homo sapiens_hsa052190.43659508
146Alcoholism_Homo sapiens_hsa050340.42656176
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.42400402
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42367985
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41234583
150GnRH signaling pathway_Homo sapiens_hsa049120.41059751
151FoxO signaling pathway_Homo sapiens_hsa040680.40958022
152Prolactin signaling pathway_Homo sapiens_hsa049170.40923989
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40586125
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.40527810
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40335395
156Shigellosis_Homo sapiens_hsa051310.40260953
157Endocytosis_Homo sapiens_hsa041440.40177469
158Pentose phosphate pathway_Homo sapiens_hsa000300.39579212
159Phagosome_Homo sapiens_hsa041450.38855090
160Insulin resistance_Homo sapiens_hsa049310.38730770
161Glycosaminoglycan degradation_Homo sapiens_hsa005310.38439647
162Long-term depression_Homo sapiens_hsa047300.38010960
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37709487
164Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37081070
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36622855
166Prion diseases_Homo sapiens_hsa050200.36069834
167VEGF signaling pathway_Homo sapiens_hsa043700.34968586
168Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34188726

Most similar genes based on co-expression Upload to Enrichr

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