JADE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.97568904
2regulation of gene silencing by RNA (GO:0060966)5.93794503
3regulation of posttranscriptional gene silencing (GO:0060147)5.93794503
4regulation of gene silencing by miRNA (GO:0060964)5.93794503
5nuclear pore complex assembly (GO:0051292)5.90725717
6establishment of integrated proviral latency (GO:0075713)4.78111924
7folic acid-containing compound biosynthetic process (GO:0009396)4.69797690
8regulation of helicase activity (GO:0051095)4.64148507
9IMP biosynthetic process (GO:0006188)4.52723312
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.51852362
11regulation of mitotic spindle checkpoint (GO:1903504)4.51852362
12regulation of histone H3-K9 methylation (GO:0051570)4.46033088
13negative regulation of DNA-dependent DNA replication (GO:2000104)4.44117993
14nucleobase biosynthetic process (GO:0046112)4.42792355
15pore complex assembly (GO:0046931)4.41585298
16histone exchange (GO:0043486)4.36081879
17negative regulation of translation, ncRNA-mediated (GO:0040033)4.34640166
18regulation of translation, ncRNA-mediated (GO:0045974)4.34640166
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.34640166
20DNA unwinding involved in DNA replication (GO:0006268)4.32257006
21DNA replication-dependent nucleosome organization (GO:0034723)4.28520946
22DNA replication-dependent nucleosome assembly (GO:0006335)4.28520946
23negative regulation of histone methylation (GO:0031061)4.27245748
24negative regulation of mitotic sister chromatid separation (GO:2000816)4.20742004
25negative regulation of sister chromatid segregation (GO:0033046)4.20742004
26negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.20742004
27negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.20742004
28negative regulation of mitotic sister chromatid segregation (GO:0033048)4.20742004
29purine nucleobase biosynthetic process (GO:0009113)4.17887798
30negative regulation of chromosome segregation (GO:0051985)4.15361528
31DNA replication initiation (GO:0006270)4.14436732
32protein localization to kinetochore (GO:0034501)4.13051775
33somatic diversification of immune receptors via somatic mutation (GO:0002566)4.09641058
34somatic hypermutation of immunoglobulin genes (GO:0016446)4.09641058
35mitotic nuclear envelope disassembly (GO:0007077)4.07280632
36determination of adult lifespan (GO:0008340)4.00016551
37pre-miRNA processing (GO:0031054)3.97283452
38heterochromatin organization (GO:0070828)3.91628276
39mitotic metaphase plate congression (GO:0007080)3.90400137
40protein K6-linked ubiquitination (GO:0085020)3.90028975
41paraxial mesoderm development (GO:0048339)3.87746809
42IMP metabolic process (GO:0046040)3.87588404
43DNA duplex unwinding (GO:0032508)3.83296565
44regulation of gene silencing (GO:0060968)3.83117090
45nuclear envelope disassembly (GO:0051081)3.82934032
46membrane disassembly (GO:0030397)3.82934032
47spindle checkpoint (GO:0031577)3.82130783
48DNA geometric change (GO:0032392)3.81983851
49mitotic spindle checkpoint (GO:0071174)3.80788643
50regulation of telomere maintenance via telomerase (GO:0032210)3.80296726
51regulation of mitotic sister chromatid separation (GO:0010965)3.75846886
52regulation of mitotic sister chromatid segregation (GO:0033047)3.75846886
53regulation of sister chromatid segregation (GO:0033045)3.75846886
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.73835080
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.73835080
56regulation of translational fidelity (GO:0006450)3.66914017
57anterior/posterior axis specification, embryo (GO:0008595)3.66815164
58mitotic spindle assembly checkpoint (GO:0007094)3.66254984
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.64871434
60L-serine metabolic process (GO:0006563)3.63845898
61regulation of nuclear cell cycle DNA replication (GO:0033262)3.59679243
62mitotic sister chromatid segregation (GO:0000070)3.59568932
63establishment of apical/basal cell polarity (GO:0035089)3.58274786
64regulation of chromosome segregation (GO:0051983)3.57786287
65spindle assembly checkpoint (GO:0071173)3.57417441
66dosage compensation (GO:0007549)3.56697384
67establishment of viral latency (GO:0019043)3.52290829
68embryonic process involved in female pregnancy (GO:0060136)3.49822880
69metaphase plate congression (GO:0051310)3.49029407
70chromatin assembly (GO:0031497)3.47995971
71sister chromatid segregation (GO:0000819)3.47004315
72regulation of DNA endoreduplication (GO:0032875)3.42515658
73regulation of mitotic spindle organization (GO:0060236)3.40672562
74histone H2A monoubiquitination (GO:0035518)3.39912534
75negative regulation of DNA recombination (GO:0045910)3.39340189
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.38599979
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.38599979
78positive regulation of mitotic sister chromatid separation (GO:1901970)3.38599979
79DNA double-strand break processing (GO:0000729)3.37681964
80regulation of spindle organization (GO:0090224)3.35586259
81protein complex localization (GO:0031503)3.35024134
82protein localization to chromosome, centromeric region (GO:0071459)3.33365621
83negative regulation of mitosis (GO:0045839)3.33140206
84regulation of translational termination (GO:0006449)3.32985698
85ATP-dependent chromatin remodeling (GO:0043044)3.32193855
86mitotic sister chromatid cohesion (GO:0007064)3.24285891
87chromatin remodeling at centromere (GO:0031055)3.23839637
88positive regulation of chromosome segregation (GO:0051984)3.22892996
89DNA strand elongation involved in DNA replication (GO:0006271)3.20580211
90mitotic G2/M transition checkpoint (GO:0044818)3.17592679
91formation of translation preinitiation complex (GO:0001731)3.16535103
92kinetochore organization (GO:0051383)3.16096747
93trophectodermal cell differentiation (GO:0001829)3.15248133
94mitotic chromosome condensation (GO:0007076)3.14909856
95tetrahydrofolate metabolic process (GO:0046653)3.14869821
96DNA replication checkpoint (GO:0000076)3.13495243
97DNA damage response, detection of DNA damage (GO:0042769)3.10811093
98regulation of protein polyubiquitination (GO:1902914)3.10757627
99ribosome assembly (GO:0042255)3.10261857
100DNA strand elongation (GO:0022616)3.09671931
101negative regulation of DNA repair (GO:0045738)3.07968586
102negative regulation of gene silencing (GO:0060969)3.03552325
103kinetochore assembly (GO:0051382)3.03291893
104regulation of cell fate specification (GO:0042659)3.03289923
105negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.03002825
106negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.02578131
107non-recombinational repair (GO:0000726)3.02128284
108double-strand break repair via nonhomologous end joining (GO:0006303)3.02128284
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01616498
110negative regulation of nuclear division (GO:0051784)3.00954201
111negative regulation of chromatin modification (GO:1903309)2.99781082
112response to X-ray (GO:0010165)2.99598847
113regulation of centrosome cycle (GO:0046605)2.98856056
114DNA ligation (GO:0006266)2.98809573
115ncRNA catabolic process (GO:0034661)2.96928310
116regulation of spindle checkpoint (GO:0090231)2.96493425
117regulation of SMAD protein import into nucleus (GO:0060390)2.95348680
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95293407
119regulation of sister chromatid cohesion (GO:0007063)2.94176072
120positive regulation of histone H3-K4 methylation (GO:0051571)2.92643689
121meiotic chromosome segregation (GO:0045132)2.92294823
122establishment of monopolar cell polarity (GO:0061162)2.91955711
123establishment or maintenance of monopolar cell polarity (GO:0061339)2.91955711
124negative regulation of histone modification (GO:0031057)2.90564070
125chaperone-mediated protein complex assembly (GO:0051131)2.90115540
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.90014578
127DNA conformation change (GO:0071103)2.89678458
128DNA strand renaturation (GO:0000733)2.89108186
129lysine metabolic process (GO:0006553)2.88669798
130lysine catabolic process (GO:0006554)2.88669798
131nuclear envelope organization (GO:0006998)2.88162833
132establishment of chromosome localization (GO:0051303)2.87417793
133ribosome biogenesis (GO:0042254)2.87295532
134CENP-A containing nucleosome assembly (GO:0034080)2.87174427
135polarized epithelial cell differentiation (GO:0030859)2.86756533
136protein localization to chromosome (GO:0034502)2.86136784
137chromatin assembly or disassembly (GO:0006333)2.86130962
138negative regulation of telomerase activity (GO:0051974)2.85035827
139spindle assembly involved in mitosis (GO:0090307)2.84259423
140regulation of centriole replication (GO:0046599)2.83661319
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83141917
142RNA-dependent DNA replication (GO:0006278)2.83023211
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.82553201
144attachment of spindle microtubules to kinetochore (GO:0008608)2.82151971
145pteridine-containing compound biosynthetic process (GO:0042559)2.81961605
146telomere maintenance via telomerase (GO:0007004)2.81817369
147DNA replication-independent nucleosome organization (GO:0034724)2.80464414
148DNA replication-independent nucleosome assembly (GO:0006336)2.80464414
149glycine metabolic process (GO:0006544)2.79788602
150regulation of chromatin silencing (GO:0031935)2.79468467
151mRNA transport (GO:0051028)2.79242985
152intra-S DNA damage checkpoint (GO:0031573)2.78857489
153telomere maintenance via semi-conservative replication (GO:0032201)2.77353187
154folic acid metabolic process (GO:0046655)2.77079135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.04631602
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.16554386
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.47311582
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35588585
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.33111164
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.33111164
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.33111164
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32940455
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.09609366
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95761101
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82902951
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.81386743
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.73801429
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.69376589
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69246360
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.61349600
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40027527
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.34968457
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.34159972
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27387999
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20303185
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16431227
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15379843
24TCF3_18692474_ChIP-Seq_MEFs_Mouse2.14245112
25ESR1_15608294_ChIP-ChIP_MCF-7_Human2.13873314
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.13328391
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07106754
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00315512
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.99885864
30TCF3_18692474_ChIP-Seq_MESCs_Mouse1.99123426
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.98956736
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.96862292
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94261838
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93130935
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.93066353
36AR_21909140_ChIP-Seq_LNCAP_Human1.92215621
37EWS_26573619_Chip-Seq_HEK293_Human1.91274721
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90621822
39FUS_26573619_Chip-Seq_HEK293_Human1.90435069
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87205677
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84148355
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81845619
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81235782
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80919351
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70413043
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66274607
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65324647
48MYC_18940864_ChIP-ChIP_HL60_Human1.60975938
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.54426408
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53888322
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53588259
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.51239681
53XRN2_22483619_ChIP-Seq_HELA_Human1.45872692
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44370924
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42870591
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.40335757
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.38481756
58SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33470800
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33302701
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31261683
61POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31082041
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30505616
63KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30157165
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28878121
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28347775
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.28199272
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28079836
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27329344
69P300_19829295_ChIP-Seq_ESCs_Human1.26745368
70MYC_22102868_ChIP-Seq_BL_Human1.26169348
71SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26159328
72ZNF263_19887448_ChIP-Seq_K562_Human1.23339179
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22309824
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21915638
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21833033
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21812645
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19831442
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19252639
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19073776
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.18979110
81ZNF274_21170338_ChIP-Seq_K562_Hela1.18600740
82KDM5A_27292631_Chip-Seq_BREAST_Human1.15028539
83VDR_23849224_ChIP-Seq_CD4+_Human1.13012563
84TAF15_26573619_Chip-Seq_HEK293_Human1.12560359
85NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12134801
86NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11836762
87TFEB_21752829_ChIP-Seq_HELA_Human1.10437546
88FOXP3_21729870_ChIP-Seq_TREG_Human1.10362648
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.07937933
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.07284611
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06801614
92KAP1_27257070_Chip-Seq_ESCs_Mouse1.06200130
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04883968
94DCP1A_22483619_ChIP-Seq_HELA_Human1.04466874
95TTF2_22483619_ChIP-Seq_HELA_Human1.04422152
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04212000
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03980306
98ELK1_19687146_ChIP-ChIP_HELA_Human1.01797326
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00667731
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00584044
101POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00453482
102POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00052679
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99963900
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99269834
105CIITA_25753668_ChIP-Seq_RAJI_Human0.99230948
106TP63_19390658_ChIP-ChIP_HaCaT_Human0.97445685
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95992063
108NANOG_16518401_ChIP-PET_MESCs_Mouse0.95273097
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94932183
110THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94834090
111GABP_19822575_ChIP-Seq_HepG2_Human0.94718444
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92306944
113IGF1R_20145208_ChIP-Seq_DFB_Human0.91675914
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90322229
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89874943
116SRF_21415370_ChIP-Seq_HL-1_Mouse0.89804989
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89220581
118IRF1_19129219_ChIP-ChIP_H3396_Human0.88270813
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.87827410
120ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86893466
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86468319
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86040465
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84781982
124GABP_17652178_ChIP-ChIP_JURKAT_Human0.84216275
125TP63_17297297_ChIP-ChIP_HaCaT_Human0.83521007
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83190237
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82909342
128VDR_22108803_ChIP-Seq_LS180_Human0.82775827
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80942003
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.80027450
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79846308
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79309025
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.79045919
134SOX9_26525672_Chip-Seq_HEART_Mouse0.76437760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.84082591
2MP0010094_abnormal_chromosome_stability3.66122612
3MP0004957_abnormal_blastocyst_morpholog3.58131368
4MP0003111_abnormal_nucleus_morphology3.51990148
5MP0010352_gastrointestinal_tract_polyps3.51603261
6MP0003693_abnormal_embryo_hatching3.49383534
7MP0003077_abnormal_cell_cycle2.95785477
8MP0003806_abnormal_nucleotide_metabolis2.93358590
9MP0003705_abnormal_hypodermis_morpholog2.80018843
10MP0010307_abnormal_tumor_latency2.43624912
11MP0002877_abnormal_melanocyte_morpholog2.42512148
12MP0001188_hyperpigmentation2.38914273
13MP0008058_abnormal_DNA_repair2.35535858
14MP0010234_abnormal_vibrissa_follicle2.34310786
15MP0004264_abnormal_extraembryonic_tissu2.24959545
16MP0001730_embryonic_growth_arrest2.24743601
17MP0003941_abnormal_skin_development2.10950243
18MP0000350_abnormal_cell_proliferation2.09912548
19MP0003123_paternal_imprinting2.08849738
20MP0004197_abnormal_fetal_growth/weight/2.06667374
21MP0001672_abnormal_embryogenesis/_devel2.03901567
22MP0005380_embryogenesis_phenotype2.03901567
23MP0002086_abnormal_extraembryonic_tissu2.02660358
24MP0002084_abnormal_developmental_patter1.99927395
25MP0008007_abnormal_cellular_replicative1.93381189
26MP0004133_heterotaxia1.85374835
27MP0001697_abnormal_embryo_size1.84793831
28MP0005076_abnormal_cell_differentiation1.84643983
29MP0003984_embryonic_growth_retardation1.83244883
30MP0003567_abnormal_fetal_cardiomyocyte1.82824211
31MP0002088_abnormal_embryonic_growth/wei1.81487542
32MP0002085_abnormal_embryonic_tissue1.75858485
33MP0003890_abnormal_embryonic-extraembry1.72866277
34MP0003136_yellow_coat_color1.72340990
35MP0003119_abnormal_digestive_system1.69888169
36MP0008932_abnormal_embryonic_tissue1.59610740
37MP0003786_premature_aging1.56502601
38MP0003566_abnormal_cell_adhesion1.56489213
39MP0002080_prenatal_lethality1.52685007
40MP0008877_abnormal_DNA_methylation1.48220001
41MP0003283_abnormal_digestive_organ1.45658697
42MP0006072_abnormal_retinal_apoptosis1.43281866
43MP0001293_anophthalmia1.41582495
44MP0005623_abnormal_meninges_morphology1.41320295
45MP0005367_renal/urinary_system_phenotyp1.41135605
46MP0000516_abnormal_urinary_system1.41135605
47MP0003121_genomic_imprinting1.37215205
48MP0002938_white_spotting1.34836172
49MP0002653_abnormal_ependyma_morphology1.23431107
50MP0001177_atelectasis1.19847408
51MP0009703_decreased_birth_body1.18732936
52MP0009697_abnormal_copulation1.15540833
53MP0005266_abnormal_metabolism1.15461486
54MP0009672_abnormal_birth_weight1.14173174
55MP0004185_abnormal_adipocyte_glucose1.14003003
56MP0000049_abnormal_middle_ear1.11286225
57MP0002254_reproductive_system_inflammat1.09638913
58MP0009379_abnormal_foot_pigmentation1.07134685
59MP0000428_abnormal_craniofacial_morphol1.06374717
60MP0006035_abnormal_mitochondrial_morpho1.06185698
61MP0001915_intracranial_hemorrhage1.05835108
62MP0000313_abnormal_cell_death1.02466970
63MP0002210_abnormal_sex_determination1.02281507
64MP0000537_abnormal_urethra_morphology1.01554180
65MP0001145_abnormal_male_reproductive1.01368902
66MP0002233_abnormal_nose_morphology1.00756134
67MP0004272_abnormal_basement_membrane1.00407769
68MP0005023_abnormal_wound_healing0.98345877
69MP0001485_abnormal_pinna_reflex0.97945930
70MP0003718_maternal_effect0.97154696
71MP0000631_abnormal_neuroendocrine_gland0.97057328
72MP0000490_abnormal_crypts_of0.96899399
73MP0003861_abnormal_nervous_system0.96786723
74MP0003122_maternal_imprinting0.95317287
75MP0002160_abnormal_reproductive_system0.94660574
76MP0001299_abnormal_eye_distance/0.94339479
77MP0002019_abnormal_tumor_incidence0.92672962
78MP0005670_abnormal_white_adipose0.92463894
79MP0009053_abnormal_anal_canal0.90484602
80MP0005085_abnormal_gallbladder_physiolo0.90123744
81MP0001849_ear_inflammation0.89974090
82MP0002111_abnormal_tail_morphology0.89371268
83MP0001661_extended_life_span0.89335481
84MP0002697_abnormal_eye_size0.87398772
85MP0001529_abnormal_vocalization0.86966752
86MP0002139_abnormal_hepatobiliary_system0.85763280
87MP0005666_abnormal_adipose_tissue0.85428778
88MP0006054_spinal_hemorrhage0.84271316
89MP0000653_abnormal_sex_gland0.83921826
90MP0005248_abnormal_Harderian_gland0.83842884
91MP0005377_hearing/vestibular/ear_phenot0.82721549
92MP0003878_abnormal_ear_physiology0.82721549
93MP0006292_abnormal_olfactory_placode0.82457622
94MP0002925_abnormal_cardiovascular_devel0.81426624
95MP0008995_early_reproductive_senescence0.79611030
96MP0001286_abnormal_eye_development0.79115533
97MP0002396_abnormal_hematopoietic_system0.78472046
98MP0002751_abnormal_autonomic_nervous0.78443780
99MP0005365_abnormal_bile_salt0.77242847
100MP0002009_preneoplasia0.76063580
101MP0005389_reproductive_system_phenotype0.75885170
102MP0000003_abnormal_adipose_tissue0.75734112
103MP0003937_abnormal_limbs/digits/tail_de0.75250193
104MP0001929_abnormal_gametogenesis0.74652535
105MP0005501_abnormal_skin_physiology0.74105995
106MP0002092_abnormal_eye_morphology0.73936305
107MP0002796_impaired_skin_barrier0.72735833
108MP0003252_abnormal_bile_duct0.72312512
109MP0005187_abnormal_penis_morphology0.71988478
110MP0003936_abnormal_reproductive_system0.71523857
111MP0005395_other_phenotype0.71116064
112MP0005375_adipose_tissue_phenotype0.69427834
113MP0002277_abnormal_respiratory_mucosa0.68077466
114MP0005621_abnormal_cell_physiology0.67988608
115MP0005391_vision/eye_phenotype0.67300328
116MP0000432_abnormal_head_morphology0.66817113
117MP0005384_cellular_phenotype0.66723552
118MP0003186_abnormal_redox_activity0.66624734
119MP0003698_abnormal_male_reproductive0.66093441
120MP0003787_abnormal_imprinting0.64809681
121MP0010030_abnormal_orbit_morphology0.64509557
122MP0000371_diluted_coat_color0.63969112
123MP0003938_abnormal_ear_development0.63875356
124MP0002736_abnormal_nociception_after0.63499229
125MP0002269_muscular_atrophy0.63255125
126MP0008770_decreased_survivor_rate0.62754698
127MP0002127_abnormal_cardiovascular_syste0.62690466
128MP0003755_abnormal_palate_morphology0.62652250
129MP0001984_abnormal_olfaction0.61091560
130MP0001119_abnormal_female_reproductive0.61004742
131MP0002102_abnormal_ear_morphology0.60742672
132MP0008789_abnormal_olfactory_epithelium0.60423123
133MP0000647_abnormal_sebaceous_gland0.59637079
134MP0002081_perinatal_lethality0.57832730
135MP0000579_abnormal_nail_morphology0.57758615
136MP0002090_abnormal_vision0.57076628
137MP0000703_abnormal_thymus_morphology0.56240302
138MP0005253_abnormal_eye_physiology0.53882889
139MP0003115_abnormal_respiratory_system0.53749277
140MP0003646_muscle_fatigue0.53378497

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.55771645
2Abnormality of the labia minora (HP:0012880)4.20390833
3Astrocytoma (HP:0009592)4.18128767
4Abnormality of the astrocytes (HP:0100707)4.18128767
5Neoplasm of the oral cavity (HP:0100649)4.01166894
6Medulloblastoma (HP:0002885)3.97411454
7Septo-optic dysplasia (HP:0100842)3.75509752
8Colon cancer (HP:0003003)3.66053458
9Rhabdomyosarcoma (HP:0002859)3.60383963
10Glioma (HP:0009733)3.56958824
11Chromsome breakage (HP:0040012)3.49761944
12Nephroblastoma (Wilms tumor) (HP:0002667)3.44897028
13Biliary tract neoplasm (HP:0100574)3.38161887
14Birth length less than 3rd percentile (HP:0003561)3.37702589
15Embryonal renal neoplasm (HP:0011794)3.25642698
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24474451
17Missing ribs (HP:0000921)3.19267250
18Abnormal lung lobation (HP:0002101)3.18845216
19Absent radius (HP:0003974)3.11328200
20Agnosia (HP:0010524)3.09810662
21Breast hypoplasia (HP:0003187)3.08894566
22Short humerus (HP:0005792)3.07992619
23Aplasia/hypoplasia of the humerus (HP:0006507)3.07740146
24Supernumerary spleens (HP:0009799)3.02526314
25Neoplasm of striated muscle (HP:0009728)2.92262423
26Aplasia involving forearm bones (HP:0009822)2.85339933
27Absent forearm bone (HP:0003953)2.85339933
28Rib fusion (HP:0000902)2.82081531
29Selective tooth agenesis (HP:0001592)2.77972196
30Impulsivity (HP:0100710)2.72759873
31Abnormality of chromosome stability (HP:0003220)2.68402194
32Abnormality of pyrimidine metabolism (HP:0004353)2.67959684
33Basal cell carcinoma (HP:0002671)2.59462430
34Shawl scrotum (HP:0000049)2.57867549
35Hypoglycemic seizures (HP:0002173)2.57374705
36Absent septum pellucidum (HP:0001331)2.57115876
37Abnormality of the septum pellucidum (HP:0007375)2.56759618
38Deviation of the thumb (HP:0009603)2.54448612
39Bilateral microphthalmos (HP:0007633)2.54387364
40Pancreatic islet-cell hyperplasia (HP:0004510)2.54070900
41Homocystinuria (HP:0002156)2.53622505
42Abnormality of homocysteine metabolism (HP:0010919)2.53622505
43Pseudobulbar signs (HP:0002200)2.52128882
44Delayed puberty (HP:0000823)2.49887711
45Abnormality of the anterior horn cell (HP:0006802)2.48238164
46Degeneration of anterior horn cells (HP:0002398)2.48238164
47Volvulus (HP:0002580)2.47908594
48Absent thumb (HP:0009777)2.46143859
49Abnormality of the salivary glands (HP:0010286)2.45571151
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.45139890
51Proximal placement of thumb (HP:0009623)2.42886399
52Abnormal hair whorl (HP:0010721)2.41581390
53Abdominal situs inversus (HP:0003363)2.40785223
54Abnormality of abdominal situs (HP:0011620)2.40785223
55Abnormal biliary tract morphology (HP:0012440)2.40279756
56Esophageal atresia (HP:0002032)2.34404374
57Hypochromic microcytic anemia (HP:0004840)2.33977994
58Maternal diabetes (HP:0009800)2.32844130
59Spastic diplegia (HP:0001264)2.32790820
60Adenoma sebaceum (HP:0009720)2.31365190
61Angiofibromas (HP:0010615)2.31365190
62Small intestinal stenosis (HP:0012848)2.31175165
63Duodenal stenosis (HP:0100867)2.31175165
64Hepatoblastoma (HP:0002884)2.29062101
65Neoplasm of the pancreas (HP:0002894)2.28023281
66Stenosis of the external auditory canal (HP:0000402)2.27553916
67Gastrointestinal carcinoma (HP:0002672)2.27109176
68Malignant gastrointestinal tract tumors (HP:0006749)2.27109176
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27068943
70Amaurosis fugax (HP:0100576)2.25619746
71Ovarian neoplasm (HP:0100615)2.22127356
72Abnormality of the lower motor neuron (HP:0002366)2.16412714
73Neoplasm of the adrenal cortex (HP:0100641)2.15729035
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.15496594
75Increased nuchal translucency (HP:0010880)2.14819848
76Intrahepatic cholestasis (HP:0001406)2.14528450
77Vertebral clefting (HP:0008428)2.14089591
7811 pairs of ribs (HP:0000878)2.14055857
79Multiple enchondromatosis (HP:0005701)2.12580109
80Neoplasm of the small intestine (HP:0100833)2.11712200
81Patellar aplasia (HP:0006443)2.11213385
82Aqueductal stenosis (HP:0002410)2.10852596
83Meckel diverticulum (HP:0002245)2.09192822
84Methylmalonic acidemia (HP:0002912)2.09046546
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05825473
86Neoplasm of the rectum (HP:0100743)2.05765165
87Oral leukoplakia (HP:0002745)2.05541704
88Squamous cell carcinoma (HP:0002860)2.05465404
89Short hallux (HP:0010109)2.05045841
90Chronic bronchitis (HP:0004469)2.03668045
91Neoplasm of the colon (HP:0100273)2.03092189
92Intestinal atresia (HP:0011100)2.00520076
93Anal stenosis (HP:0002025)2.00421415
94Abnormality of the preputium (HP:0100587)1.98845010
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98628503
96Short 1st metacarpal (HP:0010034)1.98628503
97Cafe-au-lait spot (HP:0000957)1.98414108
98Triphalangeal thumb (HP:0001199)1.98108963
99Bifid tongue (HP:0010297)1.97831059
100Reticulocytopenia (HP:0001896)1.97359736
101Sandal gap (HP:0001852)1.97046978
102Aplasia/Hypoplasia of the patella (HP:0006498)1.96784529
103Abnormality of the ileum (HP:0001549)1.96091719
104Choanal stenosis (HP:0000452)1.95160579
105Optic nerve hypoplasia (HP:0000609)1.92879203
106Myelodysplasia (HP:0002863)1.92233550
107Carpal bone hypoplasia (HP:0001498)1.92052195
108Abnormal number of incisors (HP:0011064)1.91689207
109Hypogonadotrophic hypogonadism (HP:0000044)1.91158280
110Gastrointestinal atresia (HP:0002589)1.91017553
111Abnormality of serum amino acid levels (HP:0003112)1.90860251
112Supernumerary ribs (HP:0005815)1.90831435
113Horseshoe kidney (HP:0000085)1.90144037
114Hyperinsulinemic hypoglycemia (HP:0000825)1.89783841
115Ectopic kidney (HP:0000086)1.89223051
116Intestinal polyposis (HP:0200008)1.87703433
117Vertebral fusion (HP:0002948)1.87627949
118Facial cleft (HP:0002006)1.87578384
119Uterine neoplasm (HP:0010784)1.87333263
120Aplasia/Hypoplasia of the hallux (HP:0008362)1.86919803
121Hyperglycinemia (HP:0002154)1.86779933
122Hypoplastic female external genitalia (HP:0012815)1.86374323
123Supernumerary bones of the axial skeleton (HP:0009144)1.85404233
124Intestinal polyp (HP:0005266)1.85207156
125Cellular immunodeficiency (HP:0005374)1.85033915
126Cortical dysplasia (HP:0002539)1.84534027
127Abnormality of the clitoris (HP:0000056)1.83369321
128Rectal fistula (HP:0100590)1.82001692
129Rectovaginal fistula (HP:0000143)1.82001692
130Sloping forehead (HP:0000340)1.81489788
131Hand muscle atrophy (HP:0009130)1.81236209
132Embryonal neoplasm (HP:0002898)1.80578699
133Abnormality of the pons (HP:0007361)1.79799210
134Breast aplasia (HP:0100783)1.79184345
135Facial hemangioma (HP:0000329)1.78959070
136Metaphyseal cupping (HP:0003021)1.78766189
137Anophthalmia (HP:0000528)1.77911766
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75700125
1392-3 toe syndactyly (HP:0004691)1.75612435
140Hypopigmentation of the fundus (HP:0007894)1.75175946
141Duplicated collecting system (HP:0000081)1.74735075
142Hyperglycinuria (HP:0003108)1.73987221
143Abnormality of the duodenum (HP:0002246)1.72917529
144Limb hypertonia (HP:0002509)1.72210340
145Abnormality of the carotid arteries (HP:0005344)1.72106629
146Hemivertebrae (HP:0002937)1.71511417
147IgM deficiency (HP:0002850)1.71278117
148Pancreatic fibrosis (HP:0100732)1.70329981
149Abnormality of methionine metabolism (HP:0010901)1.70294240
150Urethral obstruction (HP:0000796)1.69896619
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69829293
152Labial hypoplasia (HP:0000066)1.69488130
153Abnormality of serine family amino acid metabolism (HP:0010894)1.67209720
154Abnormality of glycine metabolism (HP:0010895)1.67209720
155Hypoplasia of the pons (HP:0012110)1.66521955
156Aplasia/Hypoplasia of the breasts (HP:0010311)1.65658378
157Pendular nystagmus (HP:0012043)1.63944503
158Shoulder girdle muscle weakness (HP:0003547)1.63836284
159Wide nose (HP:0000445)1.63714079
160Increased hepatocellular lipid droplets (HP:0006565)1.63410699
161Gonadotropin excess (HP:0000837)1.63287174
162Megaloblastic anemia (HP:0001889)1.63215755
163Abnormality of the pancreatic islet cells (HP:0006476)1.61112473
164Abnormality of endocrine pancreas physiology (HP:0012093)1.61112473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.62635642
2EPHA24.50596502
3WEE13.80673514
4CDC73.67910493
5TAF12.76237860
6TNIK2.65227812
7TTK2.59279274
8VRK22.56101252
9NEK22.43120956
10AKT32.37446404
11NEK12.37061176
12RPS6KB22.36739821
13NUAK12.22335595
14FLT32.05949701
15SRPK12.03510274
16PASK2.03117815
17MST42.01697705
18PNCK2.00077689
19SCYL21.98081507
20BRD41.96825460
21BUB11.92993875
22PLK11.80188858
23PBK1.79961851
24CDK71.79360050
25BRSK21.76472223
26PKN21.75621641
27LATS11.74384666
28NLK1.67676878
29TSSK61.64653005
30ATR1.54248708
31ZAK1.53767642
32CHEK21.53276008
33TRIM281.51296730
34EEF2K1.46956543
35TLK11.43982119
36PLK31.42195878
37STK161.41598113
38CHEK11.40729651
39DYRK21.38161844
40CDK41.36786434
41ACVR1B1.36580133
42AURKB1.30607127
43DYRK31.28518695
44BMPR1B1.27660326
45ALK1.26108844
46ATM1.25761019
47NME11.22411931
48CDK61.18078834
49MTOR1.14673887
50EIF2AK21.13668441
51MET1.13090750
52TGFBR11.08297001
53MAP3K81.08267673
54CDK191.06068266
55CDK21.04435834
56MAPKAPK31.01690880
57PAK41.01253323
58BCKDK1.00796672
59MKNK11.00117876
60STK40.98553647
61AURKA0.96868032
62MKNK20.96626271
63STK38L0.96131434
64FRK0.92917971
65PDGFRA0.90619114
66PDK20.87667216
67PIM10.87526380
68RIPK10.86737412
69PLK40.85286379
70PRKCI0.85069238
71EIF2AK10.83504441
72MELK0.83117696
73STK30.82860849
74LATS20.81749398
75MAP3K40.79151543
76VRK10.77790972
77CSNK1D0.75957821
78PLK20.74521792
79FER0.73430520
80OXSR10.73307962
81CDK10.72407169
82STK100.69915252
83CSNK1G10.69344417
84CSNK2A20.66527875
85STK240.66361285
86TEC0.66339247
87ERBB40.64506968
88EIF2AK30.64110909
89CSNK1E0.63327025
90CDK90.62126371
91PRKDC0.61792521
92CDK30.61610579
93RPS6KA40.61441686
94MAP3K100.60980920
95AKT20.56594360
96BRSK10.55726409
97MAPK140.54286317
98CLK10.53003481
99CASK0.52933713
100FGFR10.52902532
101RPS6KB10.51662706
102GRK10.50236264
103PDK30.50072636
104PDK40.50072636
105CAMK1G0.49501288
106YES10.48533887
107DMPK0.48094936
108AKT10.47553178
109PTK60.45962977
110MAPK10.45008509
111RPS6KA50.43019999
112TIE10.43010714
113UHMK10.42905090
114CSNK2A10.42557380
115GSK3B0.42110993
116CAMK1D0.41969527
117SGK20.40762811
118CSNK1G20.40443170
119WNK30.39430280
120DYRK1A0.35120000
121SMG10.34809259
122ICK0.33619589
123MAPK100.29852969
124FGFR30.27620144
125SGK4940.27569479
126SGK2230.27569479
127EGFR0.27151989
128PAK20.27021332
129GSK3A0.25942715
130TTN0.24727309
131PRKCE0.24531406
132PRKCG0.24261129
133BMX0.22909601
134FGFR20.18395305
135PRKAA10.18352665
136PTK20.18318935
137RPS6KA10.18155396

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.98136109
2One carbon pool by folate_Homo sapiens_hsa006703.77970531
3DNA replication_Homo sapiens_hsa030303.66941056
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58064449
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.15156621
6RNA transport_Homo sapiens_hsa030133.02266014
7Proteasome_Homo sapiens_hsa030502.55607446
8Spliceosome_Homo sapiens_hsa030402.46975900
9Cell cycle_Homo sapiens_hsa041102.36677256
10Homologous recombination_Homo sapiens_hsa034402.31713392
11Non-homologous end-joining_Homo sapiens_hsa034502.23063148
12Nucleotide excision repair_Homo sapiens_hsa034202.21574862
13Fanconi anemia pathway_Homo sapiens_hsa034602.20925481
14Selenocompound metabolism_Homo sapiens_hsa004502.10419409
15mRNA surveillance pathway_Homo sapiens_hsa030152.01494141
16Base excision repair_Homo sapiens_hsa034101.96759519
17Nitrogen metabolism_Homo sapiens_hsa009101.94544610
18Systemic lupus erythematosus_Homo sapiens_hsa053221.86766644
19Protein export_Homo sapiens_hsa030601.78342986
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73428324
21p53 signaling pathway_Homo sapiens_hsa041151.69471099
22Vitamin B6 metabolism_Homo sapiens_hsa007501.58073878
23RNA degradation_Homo sapiens_hsa030181.54588902
24RNA polymerase_Homo sapiens_hsa030201.52902360
25Propanoate metabolism_Homo sapiens_hsa006401.45444840
26Pyrimidine metabolism_Homo sapiens_hsa002401.42670363
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40173137
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38500343
29Biosynthesis of amino acids_Homo sapiens_hsa012301.38166999
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37955866
31Basal transcription factors_Homo sapiens_hsa030221.33713217
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32932147
33Lysine degradation_Homo sapiens_hsa003101.31278227
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30426590
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29128138
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.28696657
37Arginine biosynthesis_Homo sapiens_hsa002201.27443304
38Parkinsons disease_Homo sapiens_hsa050121.24397136
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23952866
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.23485947
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21543630
42Huntingtons disease_Homo sapiens_hsa050161.21230740
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.20972967
44Oxidative phosphorylation_Homo sapiens_hsa001901.16599644
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.15682297
46Steroid biosynthesis_Homo sapiens_hsa001001.13853417
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11230511
48Viral carcinogenesis_Homo sapiens_hsa052031.10095870
49MicroRNAs in cancer_Homo sapiens_hsa052060.98789851
50Folate biosynthesis_Homo sapiens_hsa007900.92843683
51Thyroid cancer_Homo sapiens_hsa052160.91247545
52Ribosome_Homo sapiens_hsa030100.90340437
53Caffeine metabolism_Homo sapiens_hsa002320.87967772
54Hippo signaling pathway_Homo sapiens_hsa043900.87381933
55Oocyte meiosis_Homo sapiens_hsa041140.86631291
56Wnt signaling pathway_Homo sapiens_hsa043100.85144571
57Alcoholism_Homo sapiens_hsa050340.84492867
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82371600
59TGF-beta signaling pathway_Homo sapiens_hsa043500.82000185
60Carbon metabolism_Homo sapiens_hsa012000.78779972
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77700760
62Adherens junction_Homo sapiens_hsa045200.76753962
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76424570
64Tryptophan metabolism_Homo sapiens_hsa003800.74986047
65Bladder cancer_Homo sapiens_hsa052190.70792225
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70573739
67mTOR signaling pathway_Homo sapiens_hsa041500.70146822
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66310909
69Alzheimers disease_Homo sapiens_hsa050100.65313936
70Purine metabolism_Homo sapiens_hsa002300.65177233
71Notch signaling pathway_Homo sapiens_hsa043300.64183364
72Phototransduction_Homo sapiens_hsa047440.63680294
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.63330194
74Tight junction_Homo sapiens_hsa045300.63284558
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63148040
76Small cell lung cancer_Homo sapiens_hsa052220.62709848
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.62244978
78Basal cell carcinoma_Homo sapiens_hsa052170.60988313
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60187990
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59427927
81Galactose metabolism_Homo sapiens_hsa000520.57250933
82Cardiac muscle contraction_Homo sapiens_hsa042600.52623354
83HTLV-I infection_Homo sapiens_hsa051660.52048169
84Hedgehog signaling pathway_Homo sapiens_hsa043400.51899879
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51689688
86AMPK signaling pathway_Homo sapiens_hsa041520.49297509
87Antigen processing and presentation_Homo sapiens_hsa046120.47960957
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47505538
89Arginine and proline metabolism_Homo sapiens_hsa003300.45716358
90Metabolic pathways_Homo sapiens_hsa011000.44253442
91Nicotine addiction_Homo sapiens_hsa050330.44177429
92Glucagon signaling pathway_Homo sapiens_hsa049220.43278069
93Epstein-Barr virus infection_Homo sapiens_hsa051690.43049152
94Phenylalanine metabolism_Homo sapiens_hsa003600.42667213
95Prostate cancer_Homo sapiens_hsa052150.42002681
96Fructose and mannose metabolism_Homo sapiens_hsa000510.41473215
97Fat digestion and absorption_Homo sapiens_hsa049750.41300146
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39814866
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37816049
100Fatty acid degradation_Homo sapiens_hsa000710.37189149
101Fatty acid elongation_Homo sapiens_hsa000620.36527362
102Pentose phosphate pathway_Homo sapiens_hsa000300.36408773
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34108565
104Glutathione metabolism_Homo sapiens_hsa004800.33893453
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32845206
106Taste transduction_Homo sapiens_hsa047420.32760007
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31762658
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30304515
109Complement and coagulation cascades_Homo sapiens_hsa046100.29921164
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29816808
111Pathways in cancer_Homo sapiens_hsa052000.29601457
112Herpes simplex infection_Homo sapiens_hsa051680.29454457
113beta-Alanine metabolism_Homo sapiens_hsa004100.29052290
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28998778
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28764921
116Insulin resistance_Homo sapiens_hsa049310.28722080
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27323995
118Fatty acid biosynthesis_Homo sapiens_hsa000610.26967340
119Colorectal cancer_Homo sapiens_hsa052100.26563310
120Tyrosine metabolism_Homo sapiens_hsa003500.26549678
121Pyruvate metabolism_Homo sapiens_hsa006200.26531809
122Vitamin digestion and absorption_Homo sapiens_hsa049770.25555391
123Fatty acid metabolism_Homo sapiens_hsa012120.25121355
124Chemical carcinogenesis_Homo sapiens_hsa052040.24560608
125Retinol metabolism_Homo sapiens_hsa008300.24237557
126FoxO signaling pathway_Homo sapiens_hsa040680.23118756
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22948941
128Butanoate metabolism_Homo sapiens_hsa006500.22781231
129Melanoma_Homo sapiens_hsa052180.22243780
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22082566
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21752617
132Circadian rhythm_Homo sapiens_hsa047100.20807414
133Serotonergic synapse_Homo sapiens_hsa047260.10289679
134Olfactory transduction_Homo sapiens_hsa047400.09106387
135Regulation of autophagy_Homo sapiens_hsa041400.07986041
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.07042182
137Peroxisome_Homo sapiens_hsa041460.06678309

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