JADE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.78591924
2negative regulation of cell killing (GO:0031342)4.63649907
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.63649907
4positive thymic T cell selection (GO:0045059)4.21533348
5regulation of gamma-delta T cell differentiation (GO:0045586)4.00842928
6positive T cell selection (GO:0043368)3.97349376
7negative T cell selection (GO:0043383)3.91000897
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.88822584
9negative thymic T cell selection (GO:0045060)3.87381579
10regulation of B cell receptor signaling pathway (GO:0050855)3.81939174
11thymic T cell selection (GO:0045061)3.76113493
12regulation of gamma-delta T cell activation (GO:0046643)3.71980136
13leukocyte aggregation (GO:0070486)3.68098051
14antigen processing and presentation of endogenous antigen (GO:0019883)3.61229215
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60437719
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60437719
17regulation of integrin activation (GO:0033623)3.60358709
18T cell selection (GO:0045058)3.59991705
19positive regulation of Rap GTPase activity (GO:0032854)3.57538471
20response to type I interferon (GO:0034340)3.56648823
21type I interferon signaling pathway (GO:0060337)3.53798038
22cellular response to type I interferon (GO:0071357)3.53798038
23detection of bacterium (GO:0016045)3.50963182
24NIK/NF-kappaB signaling (GO:0038061)3.45795596
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.45529003
26embryonic process involved in female pregnancy (GO:0060136)3.44341495
27detection of other organism (GO:0098543)3.42491282
28signal complex assembly (GO:0007172)3.41663578
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33920348
30protein localization to endosome (GO:0036010)3.32225876
31regulation of ARF protein signal transduction (GO:0032012)3.27803595
32tolerance induction (GO:0002507)3.24737917
33regulation of Rap GTPase activity (GO:0032317)3.23648527
34regulation of type I interferon-mediated signaling pathway (GO:0060338)3.22219781
35cellular response to zinc ion (GO:0071294)3.17030963
36negative regulation of T cell mediated immunity (GO:0002710)3.16028596
37response to interleukin-15 (GO:0070672)3.12017153
38negative regulation of lymphocyte mediated immunity (GO:0002707)3.11702112
39positive regulation of protein homooligomerization (GO:0032464)3.08956628
40regulation of ARF GTPase activity (GO:0032312)3.08076970
41negative regulation of leukocyte mediated immunity (GO:0002704)3.04517428
42response to laminar fluid shear stress (GO:0034616)3.01595735
43locomotory exploration behavior (GO:0035641)3.00747736
44mannose metabolic process (GO:0006013)3.00277408
45proline biosynthetic process (GO:0006561)2.98969646
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98719366
47regulation of interleukin-12 biosynthetic process (GO:0045075)2.95839916
48B cell receptor signaling pathway (GO:0050853)2.94328805
49B cell homeostasis (GO:0001782)2.92279988
50regulation of necroptotic process (GO:0060544)2.90880081
51negative regulation of protein oligomerization (GO:0032460)2.90720335
52response to muramyl dipeptide (GO:0032495)2.90096084
53antigen processing and presentation via MHC class Ib (GO:0002475)2.88949543
54synaptic vesicle endocytosis (GO:0048488)2.88182494
55T cell migration (GO:0072678)2.82294833
56regulation of histone H3-K27 methylation (GO:0061085)2.80709733
57negative regulation of type 2 immune response (GO:0002829)2.78779975
58CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77554854
59embryonic placenta development (GO:0001892)2.76571214
60negative regulation of interleukin-12 production (GO:0032695)2.76260576
61regulation of antigen processing and presentation (GO:0002577)2.76005485
62regulation of alpha-beta T cell proliferation (GO:0046640)2.75274963
63negative regulation of innate immune response (GO:0045824)2.75228483
64interferon-gamma-mediated signaling pathway (GO:0060333)2.74641731
65negative regulation of phagocytosis (GO:0050765)2.71473041
66positive regulation of Cdc42 GTPase activity (GO:0043089)2.70726378
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.68760453
68cellular response to interleukin-15 (GO:0071350)2.68583045
69regulation of T cell tolerance induction (GO:0002664)2.68095634
70negative regulation of granulocyte differentiation (GO:0030853)2.67927780
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.67399230
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66800417
73T cell homeostasis (GO:0043029)2.65852321
74cellular extravasation (GO:0045123)2.63929985
75detection of external biotic stimulus (GO:0098581)2.63056496
76oxygen transport (GO:0015671)2.62288109
77immunoglobulin mediated immune response (GO:0016064)2.61212364
78regulation of T-helper 2 cell differentiation (GO:0045628)2.61071319
79synaptic vesicle maturation (GO:0016188)2.60755219
80lymphocyte homeostasis (GO:0002260)2.59351061
81positive regulation of granulocyte differentiation (GO:0030854)2.59052577
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.58871482
83regulation of defense response to virus by virus (GO:0050690)2.57367232
84hepatocyte apoptotic process (GO:0097284)2.56574327
85regulation of interferon-beta biosynthetic process (GO:0045357)2.56514890
86negative regulation of erythrocyte differentiation (GO:0045647)2.54919420
87negative regulation of stress fiber assembly (GO:0051497)2.54796903
88response to peptidoglycan (GO:0032494)2.54219294
89regulation of interleukin-2 biosynthetic process (GO:0045076)2.54033281
90negative regulation of actin filament bundle assembly (GO:0032232)2.53906143
91positive regulation of histone deacetylation (GO:0031065)2.53134487
92negative regulation of necroptotic process (GO:0060546)2.52492218
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52445327
94modulation by symbiont of host cellular process (GO:0044068)2.52047437
95regulation of protein homooligomerization (GO:0032462)2.51562905
96regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51515988
97negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51281294
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.50324337
99response to host (GO:0075136)2.50324337
100response to host defenses (GO:0052200)2.50324337
101regulation of natural killer cell mediated immunity (GO:0002715)2.50042803
102regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50042803
103activation of Rac GTPase activity (GO:0032863)2.50024695
104interferon-gamma secretion (GO:0072643)2.49521387
1053-UTR-mediated mRNA stabilization (GO:0070935)2.49484301
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46693428
107positive regulation by organism of defense response of other organism involved in symbiotic interact2.46693428
108modulation by symbiont of host immune response (GO:0052553)2.46693428
109positive regulation by symbiont of host defense response (GO:0052509)2.46693428
110modulation by symbiont of host defense response (GO:0052031)2.46693428
111modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46693428
112modulation by virus of host process (GO:0019054)2.45643358
113regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.45531129
114T cell costimulation (GO:0031295)2.45415093
115natural killer cell differentiation (GO:0001779)2.45241571
116negative regulation of Ras GTPase activity (GO:0034261)2.45000110
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44426336
118macrophage activation involved in immune response (GO:0002281)2.43584240
119regulation of B cell differentiation (GO:0045577)2.42137414
120activation of JUN kinase activity (GO:0007257)2.41013680
121stress fiber assembly (GO:0043149)2.40943517
122lymphocyte costimulation (GO:0031294)2.39967323
123activated T cell proliferation (GO:0050798)2.37426572
124antigen receptor-mediated signaling pathway (GO:0050851)2.37100640
125peptidyl-threonine phosphorylation (GO:0018107)2.36907584
126T cell receptor signaling pathway (GO:0050852)2.36868071
127regulation of regulatory T cell differentiation (GO:0045589)2.36712656
128monocyte differentiation (GO:0030224)2.33137507
129neuromuscular process controlling balance (GO:0050885)2.32750362
130neuromuscular process controlling posture (GO:0050884)2.32511900
131positive regulation of B cell differentiation (GO:0045579)2.31806300
132negative regulation of viral release from host cell (GO:1902187)2.31346603
133mature B cell differentiation (GO:0002335)2.30638909
134sodium ion export (GO:0071436)2.30211424
135regulation of macrophage chemotaxis (GO:0010758)2.29749242
136mast cell degranulation (GO:0043303)2.29052560
137mast cell activation involved in immune response (GO:0002279)2.29052560
138regulation of clathrin-mediated endocytosis (GO:2000369)2.28866628
139adaptation of signaling pathway (GO:0023058)2.27791248
140replication fork processing (GO:0031297)2.25057789
141poly(A)+ mRNA export from nucleus (GO:0016973)2.23458778
142interferon-gamma production (GO:0032609)2.23074222
143adenosine receptor signaling pathway (GO:0001973)2.22848016
144mitotic G1 DNA damage checkpoint (GO:0031571)2.22708988
145positive regulation of Rac GTPase activity (GO:0032855)2.22698666
146histone H3-K36 demethylation (GO:0070544)2.22037851
147immune response-activating cell surface receptor signaling pathway (GO:0002429)2.20992590
148peptidyl-threonine modification (GO:0018210)2.20250416
149synaptic vesicle exocytosis (GO:0016079)2.19894782
150germinal center formation (GO:0002467)2.18629396
151leukocyte cell-cell adhesion (GO:0007159)2.18618751
152regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.18033645
153pre-miRNA processing (GO:0031054)2.16392787
154negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.16302607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28878521
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.52077009
3MYC_22102868_ChIP-Seq_BL_Human3.17682194
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98634128
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.71712684
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.71503741
7VDR_21846776_ChIP-Seq_THP-1_Human2.66811596
8KDM2B_26808549_Chip-Seq_DND41_Human2.49455058
9TCF7_22412390_ChIP-Seq_EML_Mouse2.45900019
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.44330090
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.42736317
12RUNX_20019798_ChIP-Seq_JUKART_Human2.31929641
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.19099803
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18855917
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18664508
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11994156
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10680305
18MAF_26560356_Chip-Seq_TH1_Human2.02879629
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.97392225
20SPI1_23127762_ChIP-Seq_K562_Human1.94098236
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.91663949
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89568220
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.89384435
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89084619
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.88578702
26LXR_22292898_ChIP-Seq_THP-1_Human1.85845584
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.83235691
28UTX_26944678_Chip-Seq_JUKART_Human1.80847838
29KDM2B_26808549_Chip-Seq_K562_Human1.80254941
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78271218
31DROSHA_22980978_ChIP-Seq_HELA_Human1.75528322
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.74574897
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74552339
34ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69459340
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65868071
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65377500
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61232481
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60612104
39MYB_26560356_Chip-Seq_TH1_Human1.58819085
40VDR_24763502_ChIP-Seq_THP-1_Human1.58544676
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55417443
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54980052
43MYB_26560356_Chip-Seq_TH2_Human1.52340657
44SPI1_23547873_ChIP-Seq_NB4_Human1.48044042
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44806903
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43543689
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.42993686
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42404387
49SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40501419
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36640041
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33734690
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.31390736
53SCL_19346495_ChIP-Seq_HPC-7_Human1.30892552
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.29775149
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29428554
56MAF_26560356_Chip-Seq_TH2_Human1.29071452
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28574220
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.25370239
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25181932
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23998735
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21949403
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21898005
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21202354
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21066300
65CIITA_25753668_ChIP-Seq_RAJI_Human1.20917765
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20181138
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19760077
68P68_20966046_ChIP-Seq_HELA_Human1.18499860
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15474518
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15210289
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14165801
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13953582
73RACK7_27058665_Chip-Seq_MCF-7_Human1.13850210
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12950050
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11667447
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10525004
77GATA1_22025678_ChIP-Seq_K562_Human1.10204113
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09092118
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.08706935
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.08420105
81BCOR_27268052_Chip-Seq_Bcells_Human1.07824165
82BP1_19119308_ChIP-ChIP_Hs578T_Human1.07435155
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06605728
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05623744
85GATA3_27048872_Chip-Seq_THYMUS_Human1.05225950
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03932780
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03928604
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03635257
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02985421
90REST_21632747_ChIP-Seq_MESCs_Mouse1.01993364
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01970251
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01624892
93GATA1_19941826_ChIP-Seq_K562_Human1.01531026
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01500335
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.98613861
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98180251
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98172158
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97823148
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97637618
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97630143
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97461533
102RUNX1_27514584_Chip-Seq_MCF-7_Human0.96407046
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96064391
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95092293
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94673202
106SMC4_20622854_ChIP-Seq_HELA_Human0.94655476
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94224030
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93948495
109PU_27001747_Chip-Seq_BMDM_Mouse0.93489786
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.93227605
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92423609
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92059731
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91418258
114CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91377100
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91302672
116CREB1_26743006_Chip-Seq_LNCaP_Human0.91091155
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90733472
118NCOR1_26117541_ChIP-Seq_K562_Human0.87806717
119AR_21572438_ChIP-Seq_LNCaP_Human0.87169001
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.86057650
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85416853
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.85006404
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84898965
124REST_18959480_ChIP-ChIP_MESCs_Mouse0.84771023
125SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84383982
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84265333
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83539305
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83346876
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81083218
130GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80189095

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.40901585
2MP0009278_abnormal_bone_marrow3.15048936
3MP0003705_abnormal_hypodermis_morpholog2.71104698
4MP0000685_abnormal_immune_system2.62030598
5MP0003763_abnormal_thymus_physiology2.59540839
6MP0003172_abnormal_lysosome_physiology2.59362864
7MP0005387_immune_system_phenotype2.51278934
8MP0001790_abnormal_immune_system2.51278934
9MP0001835_abnormal_antigen_presentation2.47823787
10MP0003300_gastrointestinal_ulcer2.44784176
11MP0003303_peritoneal_inflammation2.41187502
12MP0001800_abnormal_humoral_immune2.37844418
13MP0003045_fibrosis2.37691567
14MP0003724_increased_susceptibility_to2.37058687
15MP0008961_abnormal_basal_metabolism2.29279319
16MP0005671_abnormal_response_to2.27404546
17MP0000569_abnormal_digit_pigmentation2.25325131
18MP0002822_catalepsy2.24632061
19MP0004510_myositis2.18099946
20MP0005451_abnormal_body_composition2.13113083
21MP0001545_abnormal_hematopoietic_system1.98005588
22MP0005397_hematopoietic_system_phenotyp1.98005588
23MP0005174_abnormal_tail_pigmentation1.97997179
24MP0005058_abnormal_lysosome_morphology1.95809269
25MP0002166_altered_tumor_susceptibility1.92114883
26MP0006082_CNS_inflammation1.88077271
27MP0004381_abnormal_hair_follicle1.87911328
28MP0005310_abnormal_salivary_gland1.87633303
29MP0002398_abnormal_bone_marrow1.87561242
30MP0002452_abnormal_antigen_presenting1.85806528
31MP0002723_abnormal_immune_serum1.85276655
32MP0005000_abnormal_immune_tolerance1.78672529
33MP0002420_abnormal_adaptive_immunity1.77904352
34MP0001819_abnormal_immune_cell1.75848266
35MP0001873_stomach_inflammation1.73756354
36MP0002006_tumorigenesis1.71229410
37MP0003866_abnormal_defecation1.68920691
38MP0005076_abnormal_cell_differentiation1.68828402
39MP0002405_respiratory_system_inflammati1.67565069
40MP0001348_abnormal_lacrimal_gland1.66055968
41MP0003635_abnormal_synaptic_transmissio1.64135432
42MP0005464_abnormal_platelet_physiology1.62888586
43MP0001851_eye_inflammation1.61627368
44MP0002396_abnormal_hematopoietic_system1.61598845
45MP0008057_abnormal_DNA_replication1.61496885
46MP0008260_abnormal_autophagy1.61106637
47MP0003075_altered_response_to1.60921967
48MP0000716_abnormal_immune_system1.60039383
49MP0000689_abnormal_spleen_morphology1.59765994
50MP0000703_abnormal_thymus_morphology1.54213975
51MP0001533_abnormal_skeleton_physiology1.47085468
52MP0003787_abnormal_imprinting1.46251467
53MP0010155_abnormal_intestine_physiology1.44746657
54MP0000015_abnormal_ear_pigmentation1.42268573
55MP0002722_abnormal_immune_system1.41775236
56MP0002909_abnormal_adrenal_gland1.40838802
57MP0002063_abnormal_learning/memory/cond1.39388726
58MP0001501_abnormal_sleep_pattern1.39191112
59MP0002009_preneoplasia1.38462654
60MP0000858_altered_metastatic_potential1.37423523
61MP0003436_decreased_susceptibility_to1.35527064
62MP0008995_early_reproductive_senescence1.33191885
63MP0002064_seizures1.31581706
64MP0008874_decreased_physiological_sensi1.31088628
65MP0005025_abnormal_response_to1.29721958
66MP0002998_abnormal_bone_remodeling1.27729287
67MP0004808_abnormal_hematopoietic_stem1.25794084
68MP0002419_abnormal_innate_immunity1.25118443
69MP0002572_abnormal_emotion/affect_behav1.23754681
70MP0009046_muscle_twitch1.22742550
71MP0001849_ear_inflammation1.22383740
72MP0009745_abnormal_behavioral_response1.20992016
73MP0002429_abnormal_blood_cell1.19559462
74MP0005167_abnormal_blood-brain_barrier1.17561638
75MP0010234_abnormal_vibrissa_follicle1.17521677
76MP0008569_lethality_at_weaning1.17046689
77MP0005645_abnormal_hypothalamus_physiol1.16693797
78MP0009333_abnormal_splenocyte_physiolog1.14226331
79MP0004947_skin_inflammation1.13782520
80MP0008877_abnormal_DNA_methylation1.13070045
81MP0003453_abnormal_keratinocyte_physiol1.12208025
82MP0001853_heart_inflammation1.09598600
83MP0002877_abnormal_melanocyte_morpholog1.05147297
84MP0001845_abnormal_inflammatory_respons1.03159571
85MP0002138_abnormal_hepatobiliary_system1.01934850
86MP0003633_abnormal_nervous_system1.01837368
87MP0000371_diluted_coat_color0.99280949
88MP0009780_abnormal_chondrocyte_physiolo0.99236548
89MP0005646_abnormal_pituitary_gland0.99233930
90MP0004185_abnormal_adipocyte_glucose0.97067678
91MP0002132_abnormal_respiratory_system0.97060825
92MP0002933_joint_inflammation0.96973193
93MP0002928_abnormal_bile_duct0.93540515
94MP0003091_abnormal_cell_migration0.93437318
95MP0008469_abnormal_protein_level0.93252956
96MP0005409_darkened_coat_color0.89812274
97MP0002796_impaired_skin_barrier0.88834701
98MP0005621_abnormal_cell_physiology0.87547121
99MP0005666_abnormal_adipose_tissue0.84634964
100MP0010307_abnormal_tumor_latency0.83204596
101MP0009840_abnormal_foam_cell0.83146660
102MP0000465_gastrointestinal_hemorrhage0.82198158
103MP0005075_abnormal_melanosome_morpholog0.80436587
104MP0004130_abnormal_muscle_cell0.79793037
105MP0001502_abnormal_circadian_rhythm0.79588601
106MP0005171_absent_coat_pigmentation0.79453069
107MP0003283_abnormal_digestive_organ0.79329140
108MP0002148_abnormal_hypersensitivity_rea0.78295322
109MP0005023_abnormal_wound_healing0.76763019
110MP0004233_abnormal_muscle_weight0.75334716
111MP0005670_abnormal_white_adipose0.75325225
112MP0003566_abnormal_cell_adhesion0.74127531
113MP0003191_abnormal_cellular_cholesterol0.73429921
114MP0003183_abnormal_peptide_metabolism0.73425617
115MP0000604_amyloidosis0.73120829
116MP0004811_abnormal_neuron_physiology0.71839436
117MP0001970_abnormal_pain_threshold0.71028161
118MP0005375_adipose_tissue_phenotype0.70965703
119MP0005166_decreased_susceptibility_to0.69705292
120MP0003690_abnormal_glial_cell0.69090870
121MP0000003_abnormal_adipose_tissue0.68967904
122MP0004264_abnormal_extraembryonic_tissu0.68834793
123MP0000490_abnormal_crypts_of0.68742784
124MP0003448_altered_tumor_morphology0.67166112
125MP0002693_abnormal_pancreas_physiology0.66943179
126MP0009785_altered_susceptibility_to0.66326352
127MP0003329_amyloid_beta_deposits0.65975939
128MP0001486_abnormal_startle_reflex0.65852030
129MP0000678_abnormal_parathyroid_gland0.65529236
130MP0000249_abnormal_blood_vessel0.65418516
131MP0010352_gastrointestinal_tract_polyps0.63995027
132MP0003828_pulmonary_edema0.63787611
133MP0009115_abnormal_fat_cell0.63480170
134MP0002019_abnormal_tumor_incidence0.62196068

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)3.93892420
2Annular pancreas (HP:0001734)3.81978055
3Colitis (HP:0002583)3.78453931
4Abnormality of the fingertips (HP:0001211)3.54000412
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.41476510
6Inflammation of the large intestine (HP:0002037)3.36992029
7Cerebral aneurysm (HP:0004944)3.28657953
8Recurrent fungal infections (HP:0002841)3.27032440
9Gastrointestinal inflammation (HP:0004386)3.21258666
10Abnormality of mucopolysaccharide metabolism (HP:0011020)3.10309871
11Abnormality of polysaccharide metabolism (HP:0011012)3.10309871
12Abnormality of glycosaminoglycan metabolism (HP:0004371)3.10309871
13Urinary glycosaminoglycan excretion (HP:0003541)3.02716932
14Mucopolysacchariduria (HP:0008155)3.02716932
15Dysostosis multiplex (HP:0000943)2.99477526
16Elevated erythrocyte sedimentation rate (HP:0003565)2.96708109
17Recurrent viral infections (HP:0004429)2.92215821
18Panhypogammaglobulinemia (HP:0003139)2.84161588
19Urethral obstruction (HP:0000796)2.71532580
20T lymphocytopenia (HP:0005403)2.69300862
21Gastrointestinal infarctions (HP:0005244)2.65509743
22Abnormality of macrophages (HP:0004311)2.63121089
23Eczematoid dermatitis (HP:0000976)2.60391911
24Lymphopenia (HP:0001888)2.59620267
25Increased IgM level (HP:0003496)2.58270355
26Recurrent cutaneous fungal infections (HP:0011370)2.55894899
27Chronic mucocutaneous candidiasis (HP:0002728)2.55894899
28Intestinal fistula (HP:0100819)2.54087723
29Slow saccadic eye movements (HP:0000514)2.53328226
30IgA deficiency (HP:0002720)2.53249300
31Abnormality of T cell number (HP:0011839)2.53129500
32Fatigue (HP:0012378)2.51815731
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.49609636
34Broad face (HP:0000283)2.49280502
35Chronic otitis media (HP:0000389)2.48233511
36Agammaglobulinemia (HP:0004432)2.44987122
37Recurrent skin infections (HP:0001581)2.40572149
38Orchitis (HP:0100796)2.39787479
39Poikiloderma (HP:0001029)2.38966422
40Febrile seizures (HP:0002373)2.37891530
41Basal cell carcinoma (HP:0002671)2.36603614
42Viral hepatitis (HP:0006562)2.36042836
43Gingivitis (HP:0000230)2.35573750
44Focal motor seizures (HP:0011153)2.34238323
45Abnormality of T cells (HP:0002843)2.33294560
46Recurrent abscess formation (HP:0002722)2.33062251
47Male infertility (HP:0003251)2.32228052
48Dysmetric saccades (HP:0000641)2.31134301
49Granulocytopenia (HP:0001913)2.30704937
50Polygenic inheritance (HP:0010982)2.24673874
51Chest pain (HP:0100749)2.22192584
52Nasal polyposis (HP:0100582)2.21404685
53Spontaneous hematomas (HP:0007420)2.17793213
54Ocular albinism (HP:0001107)2.16931921
55Abnormality of the nasal mucosa (HP:0000433)2.15469736
56Interstitial pulmonary disease (HP:0006530)2.14532572
57Epistaxis (HP:0000421)2.13355267
58IgM deficiency (HP:0002850)2.13119614
59Acute lymphatic leukemia (HP:0006721)2.13056889
60Cellulitis (HP:0100658)2.12313937
61Restrictive lung disease (HP:0002091)2.11339443
62Urticaria (HP:0001025)2.10332935
63Volvulus (HP:0002580)2.08848175
64Osteomyelitis (HP:0002754)2.08835710
65Albinism (HP:0001022)2.08826238
66Macroorchidism (HP:0000053)2.08646134
67Papilledema (HP:0001085)2.08486613
68Autoimmune thrombocytopenia (HP:0001973)2.07422014
69Facial hemangioma (HP:0000329)2.06344828
70Subacute progressive viral hepatitis (HP:0006572)2.05785246
71Ulnar bowing (HP:0003031)2.05683182
72Hypoplasia of the thymus (HP:0000778)2.05639282
73Hematochezia (HP:0002573)2.05350818
74Atonic seizures (HP:0010819)2.05262004
75Recurrent bronchitis (HP:0002837)2.04822733
76Syringomyelia (HP:0003396)2.04652439
77Spinal cord lesions (HP:0100561)2.04652439
78Recurrent gram-negative bacterial infections (HP:0005420)2.04398328
79Increased CSF protein (HP:0002922)2.04316516
80Pulmonary embolism (HP:0002204)2.04081878
81Focal seizures (HP:0007359)2.02492350
82Visual hallucinations (HP:0002367)2.01955493
83Myokymia (HP:0002411)2.00822896
84Retrobulbar optic neuritis (HP:0100654)2.00076784
85Optic neuritis (HP:0100653)2.00076784
86Arterial thrombosis (HP:0004420)2.00035694
87Pulmonary infiltrates (HP:0002113)1.98535072
88Impaired smooth pursuit (HP:0007772)1.98488771
89Polycythemia (HP:0001901)1.97905799
90Hemiplegia (HP:0002301)1.97751305
91Abnormality of T cell physiology (HP:0011840)1.97546065
92Sepsis (HP:0100806)1.97470543
93Distal lower limb amyotrophy (HP:0008944)1.96931403
94Obstructive lung disease (HP:0006536)1.96880905
95Chronic obstructive pulmonary disease (HP:0006510)1.96880905
96Encephalitis (HP:0002383)1.96668497
97Progressive hearing impairment (HP:0001730)1.96118023
98Gingival bleeding (HP:0000225)1.95840417
99Mediastinal lymphadenopathy (HP:0100721)1.95763748
100Recurrent bacterial skin infections (HP:0005406)1.95338380
101Meningitis (HP:0001287)1.94483251
102Postural instability (HP:0002172)1.93066608
103Persistence of primary teeth (HP:0006335)1.91623819
104Hypergammaglobulinemia (HP:0010702)1.91299881
105Coarse hair (HP:0002208)1.91256396
106Micronodular cirrhosis (HP:0001413)1.90691716
107Asymmetric septal hypertrophy (HP:0001670)1.90336246
108Obstructive sleep apnea (HP:0002870)1.90254515
109Hemoptysis (HP:0002105)1.85632970
110Prolonged bleeding time (HP:0003010)1.85230675
111Autoimmune hemolytic anemia (HP:0001890)1.85152067
112Glucose intolerance (HP:0000833)1.85068001
113Anorexia (HP:0002039)1.84946077
114Heterotopia (HP:0002282)1.84805495
115Hypercortisolism (HP:0001578)1.84027871
116Short chin (HP:0000331)1.83144627
117Increased IgE level (HP:0003212)1.82550400
118Abnormality of the periventricular white matter (HP:0002518)1.82413469
119Malnutrition (HP:0004395)1.82062532
120Emphysema (HP:0002097)1.79752193
121Skin ulcer (HP:0200042)1.78672393
122Iris hypopigmentation (HP:0007730)1.78607091
123Gastrointestinal dysmotility (HP:0002579)1.78242019
124Myositis (HP:0100614)1.76533327
125Clumsiness (HP:0002312)1.75802625
126Verrucae (HP:0200043)1.75420578
127Papilloma (HP:0012740)1.75420578
128Increased connective tissue (HP:0009025)1.75324799
129Hyperacusis (HP:0010780)1.74640319
130Rib fusion (HP:0000902)1.74310714
131Recurrent sinusitis (HP:0011108)1.73308263
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72120232
133Myocardial infarction (HP:0001658)1.72035579
134IgG deficiency (HP:0004315)1.71464927
135Stomatitis (HP:0010280)1.70167490
136Striae distensae (HP:0001065)1.67371584
137Gastrointestinal stroma tumor (HP:0100723)1.67169491
138Increased cerebral lipofuscin (HP:0011813)1.67129012
139Esophageal varix (HP:0002040)1.67000475
140Progressive sensorineural hearing impairment (HP:0000408)1.66760237
141Cheilitis (HP:0100825)1.66511909
142Turricephaly (HP:0000262)1.66196835
143Abnormality of oral frenula (HP:0000190)1.64942424
144Abnormality of the thoracic spine (HP:0100711)1.64818688
145Teleangiectasia of the skin (HP:0100585)1.64067787
146Dilatation of the ascending aorta (HP:0005111)1.63932527
147Chronic diarrhea (HP:0002028)1.63474608
148Abnormality of male internal genitalia (HP:0000022)1.63453774
149Frequent falls (HP:0002359)1.63388885
150Lymphoma (HP:0002665)1.63097179
151Arterial tortuosity (HP:0005116)1.63038894
152Abnormality of the peritoneum (HP:0002585)1.62695280
153Growth hormone excess (HP:0000845)1.62267233
154Leukocytosis (HP:0001974)1.61733991
155Vasculitis (HP:0002633)1.61463799
156Abnormality of binocular vision (HP:0011514)1.60575701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.54975121
2ERN12.95872590
3SMG12.68342791
4MAPK152.60330192
5MAP3K62.54531856
6ICK2.31681181
7MAP2K32.10514976
8SIK12.09823070
9RIPK42.06458188
10TYRO32.00745097
11PRKD22.00722511
12SIK21.98078114
13MAP3K91.93083680
14MAP3K131.92200074
15EEF2K1.90557477
16FGR1.79769119
17CDK121.71968722
18TNK21.69632022
19CSK1.69182188
20MAP3K31.65788547
21JAK31.60480067
22DAPK11.58583076
23TAOK11.56991837
24TRIB31.56471197
25TXK1.54602018
26MAP3K111.54117876
27BMX1.51921810
28FES1.44122344
29JAK11.42153895
30DDR21.39457717
31PRKCH1.37738405
32PDGFRA1.37252644
33EPHA41.31912051
34TGFBR21.28588112
35HIPK21.28516449
36NTRK31.26063349
37TYK21.25464131
38MATK1.20347589
39ALK1.19370264
40PINK11.18772662
41EPHB11.18140778
42TTN1.15088671
43RIPK11.14429953
44PRKD31.10559126
45MARK21.08973962
46CAMK1D1.08756569
47HCK1.07985981
48TAOK31.07695759
49STK381.06834453
50MAP3K101.06805299
51CAMK1G1.06361640
52ZAP701.04212389
53MAP3K141.01487328
54UHMK10.99927779
55CDC42BPA0.99595899
56ITK0.98960034
57DMPK0.97867873
58PKN20.97036124
59SYK0.96961167
60MAP3K70.96833442
61CSF1R0.96576149
62KSR20.94102149
63STK100.93212767
64PDGFRB0.93207296
65JAK20.92713566
66LCK0.92529346
67CAMKK10.91100347
68PRPF4B0.90778772
69PTK60.88961623
70PAK60.88785647
71SGK30.87363850
72CDK40.86370053
73DAPK20.86103661
74MAPK120.85103501
75TAOK20.83924870
76RPS6KB20.82464556
77PDPK10.82122788
78MELK0.81878814
79FGFR30.80779515
80IKBKE0.80645781
81NTRK20.80362299
82RAF10.79622879
83GRK60.78826870
84CDK60.77252662
85LMTK20.73223885
86MAP2K20.72891004
87PIM10.72431942
88MAPK70.71976143
89MTOR0.71627670
90PDK10.71434116
91TRPM70.68752555
92IKBKB0.66944822
93FGFR40.66728551
94CHUK0.64958095
95MAP3K10.64231179
96RET0.63147968
97PASK0.63079032
98MST1R0.61828941
99IRAK20.61383895
100STK110.60550312
101LYN0.60348644
102CDK90.60018142
103SGK10.59491168
104KIT0.58372547
105BTK0.58232786
106IRAK30.58012295
107MAPK110.57462781
108RPS6KL10.57174288
109RPS6KC10.57174288
110YES10.57168052
111MARK30.56765739
112RPS6KA60.56279363
113EPHA20.53223770
114LRRK20.52358654
115MAP3K20.51294994
116NEK60.51057934
117CAMK40.50145313
118SIK30.47741558
119EGFR0.47331654
120MAPK100.45922640
121MAP3K40.45893678
122SGK20.45611599
123PAK40.45209496
124NME20.44895256
125TBK10.44526979
126BLK0.44209693
127NEK90.43484017
128CDK50.43429118
129RPS6KA20.43337136
130IRAK40.43263812
131BMPR20.42369429
132PRKG20.41588160
133MAP3K80.41355000
134TEC0.40281239

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.15679848
2B cell receptor signaling pathway_Homo sapiens_hsa046621.96482601
3Autoimmune thyroid disease_Homo sapiens_hsa053201.90662356
4Allograft rejection_Homo sapiens_hsa053301.89654841
5Graft-versus-host disease_Homo sapiens_hsa053321.86909740
6Olfactory transduction_Homo sapiens_hsa047401.62061804
7Other glycan degradation_Homo sapiens_hsa005111.58643565
8T cell receptor signaling pathway_Homo sapiens_hsa046601.54434142
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53953121
10Viral myocarditis_Homo sapiens_hsa054161.48888765
11Osteoclast differentiation_Homo sapiens_hsa043801.48607671
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43396096
13mTOR signaling pathway_Homo sapiens_hsa041501.42342035
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38688821
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34823387
16Chemokine signaling pathway_Homo sapiens_hsa040621.34126956
17Dorso-ventral axis formation_Homo sapiens_hsa043201.33768726
18Long-term potentiation_Homo sapiens_hsa047201.33313511
19Hepatitis C_Homo sapiens_hsa051601.26432971
20Morphine addiction_Homo sapiens_hsa050321.26122469
21VEGF signaling pathway_Homo sapiens_hsa043701.25222227
22Fatty acid biosynthesis_Homo sapiens_hsa000611.24797923
23Chronic myeloid leukemia_Homo sapiens_hsa052201.24138831
24Renal cell carcinoma_Homo sapiens_hsa052111.20613395
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.18113138
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16781048
27Thyroid cancer_Homo sapiens_hsa052161.15831136
28Acute myeloid leukemia_Homo sapiens_hsa052211.15199481
29Leishmaniasis_Homo sapiens_hsa051401.15174074
30Type II diabetes mellitus_Homo sapiens_hsa049301.15006864
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13798524
32GnRH signaling pathway_Homo sapiens_hsa049121.12276547
33Circadian rhythm_Homo sapiens_hsa047101.11891571
34Measles_Homo sapiens_hsa051621.10128785
35Prolactin signaling pathway_Homo sapiens_hsa049171.10023571
36Salivary secretion_Homo sapiens_hsa049701.09695681
37Amphetamine addiction_Homo sapiens_hsa050311.09408678
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.08966716
39Apoptosis_Homo sapiens_hsa042101.06670650
40ErbB signaling pathway_Homo sapiens_hsa040121.05954582
41Nicotine addiction_Homo sapiens_hsa050331.05910704
42Estrogen signaling pathway_Homo sapiens_hsa049151.05288821
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05206925
44Notch signaling pathway_Homo sapiens_hsa043301.03083547
45Glutamatergic synapse_Homo sapiens_hsa047241.03040467
46Choline metabolism in cancer_Homo sapiens_hsa052311.02693926
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.02276752
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02179609
49Circadian entrainment_Homo sapiens_hsa047131.01832862
50MAPK signaling pathway_Homo sapiens_hsa040101.01685994
51Insulin secretion_Homo sapiens_hsa049111.00429845
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00351705
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00244112
54Gastric acid secretion_Homo sapiens_hsa049710.99133761
55HTLV-I infection_Homo sapiens_hsa051660.99096690
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98029316
57Glioma_Homo sapiens_hsa052140.97949413
58Non-small cell lung cancer_Homo sapiens_hsa052230.97141424
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96745967
60Pancreatic cancer_Homo sapiens_hsa052120.96183010
61Oxytocin signaling pathway_Homo sapiens_hsa049210.92982474
62Asthma_Homo sapiens_hsa053100.92726359
63Cholinergic synapse_Homo sapiens_hsa047250.92149374
64Viral carcinogenesis_Homo sapiens_hsa052030.91605273
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91187832
66Platelet activation_Homo sapiens_hsa046110.90629690
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89631552
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89494228
69Type I diabetes mellitus_Homo sapiens_hsa049400.89369700
70Hepatitis B_Homo sapiens_hsa051610.89097530
71GABAergic synapse_Homo sapiens_hsa047270.88918330
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88488437
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.88180204
74Renin secretion_Homo sapiens_hsa049240.87917754
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87772721
76Prostate cancer_Homo sapiens_hsa052150.87143634
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.86406621
78Colorectal cancer_Homo sapiens_hsa052100.86020780
79Synaptic vesicle cycle_Homo sapiens_hsa047210.85635465
80Inositol phosphate metabolism_Homo sapiens_hsa005620.85380471
81Dopaminergic synapse_Homo sapiens_hsa047280.84664672
82Tuberculosis_Homo sapiens_hsa051520.84039359
83Cocaine addiction_Homo sapiens_hsa050300.83969033
84Small cell lung cancer_Homo sapiens_hsa052220.83964204
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.83704036
86Hematopoietic cell lineage_Homo sapiens_hsa046400.83672798
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83644650
88Epstein-Barr virus infection_Homo sapiens_hsa051690.81651119
89cAMP signaling pathway_Homo sapiens_hsa040240.81391936
90Lysine degradation_Homo sapiens_hsa003100.81245966
91Shigellosis_Homo sapiens_hsa051310.81100622
92Adherens junction_Homo sapiens_hsa045200.80303953
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.78949457
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78333251
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77606390
96Rap1 signaling pathway_Homo sapiens_hsa040150.77411401
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77324182
98Long-term depression_Homo sapiens_hsa047300.76810007
99Insulin resistance_Homo sapiens_hsa049310.76346319
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75378548
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74904614
102FoxO signaling pathway_Homo sapiens_hsa040680.74316159
103Gap junction_Homo sapiens_hsa045400.73565836
104Toxoplasmosis_Homo sapiens_hsa051450.73516697
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72611191
106Endocytosis_Homo sapiens_hsa041440.72527474
107Endometrial cancer_Homo sapiens_hsa052130.72415172
108Calcium signaling pathway_Homo sapiens_hsa040200.71970419
109Antigen processing and presentation_Homo sapiens_hsa046120.71788256
110TNF signaling pathway_Homo sapiens_hsa046680.71451285
111Staphylococcus aureus infection_Homo sapiens_hsa051500.70899176
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70607709
113Insulin signaling pathway_Homo sapiens_hsa049100.70279136
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.69165584
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68354343
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66795928
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66129949
118Malaria_Homo sapiens_hsa051440.65122479
119Influenza A_Homo sapiens_hsa051640.64552096
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.63328142
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60231850
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.59009189
123African trypanosomiasis_Homo sapiens_hsa051430.58988491
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58957605
125Herpes simplex infection_Homo sapiens_hsa051680.58391348
126MicroRNAs in cancer_Homo sapiens_hsa052060.57974546
127Proteoglycans in cancer_Homo sapiens_hsa052050.57598411
128Ras signaling pathway_Homo sapiens_hsa040140.57144771
129HIF-1 signaling pathway_Homo sapiens_hsa040660.56922082
130Bladder cancer_Homo sapiens_hsa052190.51910661
131Focal adhesion_Homo sapiens_hsa045100.50445782
132Pentose phosphate pathway_Homo sapiens_hsa000300.46896970
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46484805
134Legionellosis_Homo sapiens_hsa051340.45712589

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