JADE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.86106515
2nuclear pore organization (GO:0006999)5.80671605
3nuclear pore complex assembly (GO:0051292)5.65008589
4Golgi transport vesicle coating (GO:0048200)5.08910916
5COPI coating of Golgi vesicle (GO:0048205)5.08910916
6DNA synthesis involved in DNA repair (GO:0000731)5.02911609
7chromosome organization involved in meiosis (GO:0070192)4.87782395
8folic acid-containing compound biosynthetic process (GO:0009396)4.40753605
9sister chromatid cohesion (GO:0007062)4.36250856
10DNA replication-dependent nucleosome assembly (GO:0006335)4.21069700
11DNA replication-dependent nucleosome organization (GO:0034723)4.21069700
12histone H2A monoubiquitination (GO:0035518)4.13844110
13regulation of gene silencing by RNA (GO:0060966)4.08782788
14regulation of posttranscriptional gene silencing (GO:0060147)4.08782788
15regulation of gene silencing by miRNA (GO:0060964)4.08782788
16pore complex assembly (GO:0046931)4.05081350
17heterochromatin organization (GO:0070828)4.03449555
18mitotic nuclear envelope disassembly (GO:0007077)3.97328707
19male meiosis I (GO:0007141)3.91719102
20pre-miRNA processing (GO:0031054)3.90320219
21DNA unwinding involved in DNA replication (GO:0006268)3.88975944
22IMP biosynthetic process (GO:0006188)3.83910916
23mitotic chromosome condensation (GO:0007076)3.80290140
24nuclear envelope disassembly (GO:0051081)3.79342591
25membrane disassembly (GO:0030397)3.79342591
26nucleobase biosynthetic process (GO:0046112)3.77181587
27negative regulation of histone methylation (GO:0031061)3.74611962
28regulation of histone H3-K9 methylation (GO:0051570)3.66489550
29purine nucleobase biosynthetic process (GO:0009113)3.60559319
30mitotic sister chromatid cohesion (GO:0007064)3.59557905
31establishment of integrated proviral latency (GO:0075713)3.58369915
32chromatin assembly (GO:0031497)3.57976891
33DNA strand elongation (GO:0022616)3.57745310
34gene silencing by RNA (GO:0031047)3.53853733
35dosage compensation (GO:0007549)3.53661553
36regulation of meiosis I (GO:0060631)3.53482923
37meiotic nuclear division (GO:0007126)3.53246111
38protein localization to kinetochore (GO:0034501)3.51211733
39DNA methylation involved in gamete generation (GO:0043046)3.49292022
40CENP-A containing nucleosome assembly (GO:0034080)3.45893076
41paraxial mesoderm development (GO:0048339)3.42210572
42regulation of RNA export from nucleus (GO:0046831)3.40880384
43male meiosis (GO:0007140)3.39823381
44synaptonemal complex assembly (GO:0007130)3.37343630
45protein localization to chromosome (GO:0034502)3.36601330
46regulation of DNA endoreduplication (GO:0032875)3.33656587
47DNA duplex unwinding (GO:0032508)3.32219319
48DNA geometric change (GO:0032392)3.30577735
49meiosis I (GO:0007127)3.28209894
50telomere maintenance via semi-conservative replication (GO:0032201)3.24586074
51regulation of transcription from RNA polymerase I promoter (GO:0006356)3.22734693
52translesion synthesis (GO:0019985)3.21939549
53meiotic cell cycle process (GO:1903046)3.21435271
54piRNA metabolic process (GO:0034587)3.20670030
55anterior/posterior axis specification, embryo (GO:0008595)3.19865666
56DNA replication initiation (GO:0006270)3.16615331
57histone H3-K36 demethylation (GO:0070544)3.14495122
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13223403
59oocyte development (GO:0048599)3.12704360
60protein K6-linked ubiquitination (GO:0085020)3.12667933
61meiotic chromosome segregation (GO:0045132)3.10644190
62double-strand break repair via nonhomologous end joining (GO:0006303)3.09860832
63non-recombinational repair (GO:0000726)3.09860832
64mitotic metaphase plate congression (GO:0007080)3.08099680
65regulation of helicase activity (GO:0051095)3.07802668
66histone exchange (GO:0043486)3.05898699
67regulation of centriole replication (GO:0046599)3.05772181
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05662148
69DNA topological change (GO:0006265)3.04993303
70IMP metabolic process (GO:0046040)3.04835134
71kinetochore organization (GO:0051383)3.04430450
72resolution of meiotic recombination intermediates (GO:0000712)3.03712173
73synaptonemal complex organization (GO:0070193)3.02966913
74trophectodermal cell differentiation (GO:0001829)3.02846132
75metaphase plate congression (GO:0051310)3.02138416
76regulation of sister chromatid segregation (GO:0033045)3.02127509
77regulation of mitotic sister chromatid separation (GO:0010965)3.02127509
78regulation of mitotic sister chromatid segregation (GO:0033047)3.02127509
79regulation of sister chromatid cohesion (GO:0007063)3.01635351
80protein complex localization (GO:0031503)3.01448367
81DNA ligation (GO:0006266)3.01373524
82attachment of spindle microtubules to kinetochore (GO:0008608)2.99132578
83chromosome condensation (GO:0030261)2.97743836
84sister chromatid segregation (GO:0000819)2.94611667
85histone H2A ubiquitination (GO:0033522)2.94514025
86chromatin assembly or disassembly (GO:0006333)2.93919670
87mRNA transport (GO:0051028)2.93393215
88nuclear envelope organization (GO:0006998)2.92926365
89regulation of centrosome cycle (GO:0046605)2.91529579
90DNA packaging (GO:0006323)2.91465780
91gene silencing (GO:0016458)2.90765559
92establishment of chromosome localization (GO:0051303)2.90046394
93cellular protein complex localization (GO:0034629)2.89936340
94formation of translation preinitiation complex (GO:0001731)2.89569306
95COPII vesicle coating (GO:0048208)2.88590785
96negative regulation of meiosis (GO:0045835)2.88083059
97regulation of DNA damage checkpoint (GO:2000001)2.88016931
98positive regulation of mitotic sister chromatid separation (GO:1901970)2.88006367
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88006367
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88006367
101postreplication repair (GO:0006301)2.87630117
102somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87319335
103somatic hypermutation of immunoglobulin genes (GO:0016446)2.87319335
104chromatin remodeling at centromere (GO:0031055)2.87127619
105ATP-dependent chromatin remodeling (GO:0043044)2.86602249
106DNA replication-independent nucleosome organization (GO:0034724)2.86496115
107DNA replication-independent nucleosome assembly (GO:0006336)2.86496115
108peptidyl-lysine dimethylation (GO:0018027)2.86249400
109spindle assembly checkpoint (GO:0071173)2.85787406
110regulation of spindle organization (GO:0090224)2.84708920
111protein localization to chromosome, centromeric region (GO:0071459)2.83143050
112regulation of chromosome segregation (GO:0051983)2.82638170
113mitotic spindle assembly checkpoint (GO:0007094)2.82027844
114negative regulation of chromosome segregation (GO:0051985)2.81927968
115DNA strand elongation involved in DNA replication (GO:0006271)2.81912652
116histone H2B ubiquitination (GO:0033523)2.81692857
117regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81187422
118histone H3-K9 demethylation (GO:0033169)2.80916465
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80792940
120mitotic spindle checkpoint (GO:0071174)2.80188862
121establishment of apical/basal cell polarity (GO:0035089)2.79775317
122regulation of gene silencing (GO:0060968)2.79027971
123monoubiquitinated protein deubiquitination (GO:0035520)2.78883107
124chromosome organization (GO:0051276)2.78713364
125mitotic recombination (GO:0006312)2.78713159
126regulation of centrosome duplication (GO:0010824)2.78596389
127glucocorticoid receptor signaling pathway (GO:0042921)2.78330847
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.77988875
129DNA replication checkpoint (GO:0000076)2.77883327
130regulation of translational fidelity (GO:0006450)2.76972662
131spindle checkpoint (GO:0031577)2.76871862
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76549077
133negative regulation of sister chromatid segregation (GO:0033046)2.76549077
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.76549077
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76549077
136positive regulation of chromosome segregation (GO:0051984)2.74325141
137telomere maintenance via recombination (GO:0000722)2.74103045
138mitotic sister chromatid segregation (GO:0000070)2.73620641
139sex determination (GO:0007530)2.73586307
140nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.73545210
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73293018
142chromosome segregation (GO:0007059)2.72425452
143negative regulation of DNA repair (GO:0045738)2.72249713
144ribosome assembly (GO:0042255)2.71869414
145regulation of nucleobase-containing compound transport (GO:0032239)2.71713512
146DNA conformation change (GO:0071103)2.68573667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.97612924
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.19831004
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.11199062
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.38883283
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.33719606
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.05008711
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.01344567
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79212690
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49706556
10NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46686511
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.46454193
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37922857
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.34768423
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33718956
15AR_21909140_ChIP-Seq_LNCAP_Human2.25602096
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23447917
17MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06796644
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01208226
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98418388
20RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90100885
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89849363
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88979448
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88979448
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88979448
25ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84744751
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83231406
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79719429
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78071731
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75180184
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74914715
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72751693
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72236443
33XRN2_22483619_ChIP-Seq_HELA_Human1.68744931
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.66384683
35MYC_22102868_ChIP-Seq_BL_Human1.63459010
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.62813741
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62205407
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.61081239
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.59559060
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.59307458
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59294028
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.57677739
43KDM5A_27292631_Chip-Seq_BREAST_Human1.56788803
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56686529
45TFEB_21752829_ChIP-Seq_HELA_Human1.55782154
46ELK1_19687146_ChIP-ChIP_HELA_Human1.54658479
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53943110
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51853952
49VDR_23849224_ChIP-Seq_CD4+_Human1.49700872
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.47692082
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46777555
52GABP_19822575_ChIP-Seq_HepG2_Human1.44212323
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44018409
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43043675
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42629144
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42063785
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40025520
58DCP1A_22483619_ChIP-Seq_HELA_Human1.38294798
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.37173112
60CIITA_25753668_ChIP-Seq_RAJI_Human1.35980529
61FOXP3_21729870_ChIP-Seq_TREG_Human1.35568428
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30355464
63CHD1_26751641_Chip-Seq_LNCaP_Human1.28773966
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.28527016
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28503035
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27465412
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26521829
68TTF2_22483619_ChIP-Seq_HELA_Human1.26036236
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.24020117
70JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23114517
71GATA1_22025678_ChIP-Seq_K562_Human1.23046978
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19903577
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18269457
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.17096491
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17004387
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16848699
77CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16661660
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16186027
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14330017
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14152718
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12504037
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11471366
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11418036
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08764382
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08474794
86TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07652411
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06152113
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05866401
89TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05133327
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05129794
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04770487
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04621073
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.04099465
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02319643
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02019310
96ZNF263_19887448_ChIP-Seq_K562_Human1.01773318
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01017321
98CLOCK_20551151_ChIP-Seq_293T_Human0.98475787
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98185013
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97799850
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97306551
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96698804
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96678481
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95599621
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94523026
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93885797
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93728427
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93643743
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92041953
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91648469
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90417543
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.85860638
113WT1_19549856_ChIP-ChIP_CCG9911_Human0.82371461
114TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80833627
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80665157
116MYC_18940864_ChIP-ChIP_HL60_Human0.80355560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting3.78342579
2MP0008877_abnormal_DNA_methylation3.55297093
3MP0003693_abnormal_embryo_hatching3.51517743
4MP0004957_abnormal_blastocyst_morpholog3.10194331
5MP0008057_abnormal_DNA_replication3.09705953
6MP0010094_abnormal_chromosome_stability3.02185161
7MP0002877_abnormal_melanocyte_morpholog2.97925017
8MP0004264_abnormal_extraembryonic_tissu2.92160943
9MP0003121_genomic_imprinting2.76160587
10MP0003111_abnormal_nucleus_morphology2.71211727
11MP0010352_gastrointestinal_tract_polyps2.67757924
12MP0003077_abnormal_cell_cycle2.60904281
13MP0005076_abnormal_cell_differentiation2.53758534
14MP0010030_abnormal_orbit_morphology2.39766084
15MP0001730_embryonic_growth_arrest2.28673777
16MP0008058_abnormal_DNA_repair2.25591857
17MP0003890_abnormal_embryonic-extraembry2.22169347
18MP0010307_abnormal_tumor_latency2.13447725
19MP0003283_abnormal_digestive_organ2.07810656
20MP0004197_abnormal_fetal_growth/weight/1.99922149
21MP0006054_spinal_hemorrhage1.97010461
22MP0003786_premature_aging1.93699824
23MP0008007_abnormal_cellular_replicative1.90950746
24MP0003119_abnormal_digestive_system1.90322496
25MP0002084_abnormal_developmental_patter1.89979993
26MP0008995_early_reproductive_senescence1.88230116
27MP0002086_abnormal_extraembryonic_tissu1.82594478
28MP0000350_abnormal_cell_proliferation1.82419879
29MP0005380_embryogenesis_phenotype1.80585247
30MP0001672_abnormal_embryogenesis/_devel1.80585247
31MP0003122_maternal_imprinting1.78941498
32MP0001697_abnormal_embryo_size1.75265574
33MP0003984_embryonic_growth_retardation1.70862170
34MP0002088_abnormal_embryonic_growth/wei1.69212671
35MP0003787_abnormal_imprinting1.68829935
36MP0010234_abnormal_vibrissa_follicle1.64499288
37MP0003136_yellow_coat_color1.61829569
38MP0002085_abnormal_embryonic_tissue1.58803290
39MP0009697_abnormal_copulation1.56482036
40MP0003705_abnormal_hypodermis_morpholog1.54078569
41MP0003567_abnormal_fetal_cardiomyocyte1.49589814
42MP0002080_prenatal_lethality1.48117131
43MP0002210_abnormal_sex_determination1.46569731
44MP0000383_abnormal_hair_follicle1.46226321
45MP0000537_abnormal_urethra_morphology1.43076536
46MP0004233_abnormal_muscle_weight1.41412925
47MP0008932_abnormal_embryonic_tissue1.40310125
48MP0003718_maternal_effect1.39671631
49MP0000566_synostosis1.38853379
50MP0001145_abnormal_male_reproductive1.36257488
51MP0001286_abnormal_eye_development1.32526221
52MP0000013_abnormal_adipose_tissue1.31277202
53MP0010678_abnormal_skin_adnexa1.31149525
54MP0001944_abnormal_pancreas_morphology1.27248851
55MP0009703_decreased_birth_body1.27102339
56MP0003566_abnormal_cell_adhesion1.26841421
57MP0001929_abnormal_gametogenesis1.26436272
58MP0000678_abnormal_parathyroid_gland1.21668801
59MP0005187_abnormal_penis_morphology1.21178404
60MP0002693_abnormal_pancreas_physiology1.20807779
61MP0009672_abnormal_birth_weight1.18575822
62MP0001293_anophthalmia1.16961574
63MP0000653_abnormal_sex_gland1.15365468
64MP0002653_abnormal_ependyma_morphology1.14466637
65MP0002233_abnormal_nose_morphology1.12107117
66MP0002249_abnormal_larynx_morphology1.11439859
67MP0002796_impaired_skin_barrier1.11359116
68MP0001346_abnormal_lacrimal_gland1.11017452
69MP0003942_abnormal_urinary_system1.08387236
70MP0003943_abnormal_hepatobiliary_system1.06429016
71MP0006072_abnormal_retinal_apoptosis1.06299004
72MP0000569_abnormal_digit_pigmentation1.04606161
73MP0003861_abnormal_nervous_system1.02687868
74MP0000003_abnormal_adipose_tissue1.01509398
75MP0000313_abnormal_cell_death1.01442544
76MP0005409_darkened_coat_color1.00191415
77MP0002009_preneoplasia0.99338993
78MP0000647_abnormal_sebaceous_gland0.99036295
79MP0000428_abnormal_craniofacial_morphol0.98905666
80MP0000579_abnormal_nail_morphology0.98771453
81MP0003878_abnormal_ear_physiology0.97228312
82MP0005377_hearing/vestibular/ear_phenot0.97228312
83MP0009780_abnormal_chondrocyte_physiolo0.97157980
84MP0005220_abnormal_exocrine_pancreas0.96478900
85MP0003385_abnormal_body_wall0.96471362
86MP0000432_abnormal_head_morphology0.94375384
87MP0004808_abnormal_hematopoietic_stem0.94060708
88MP0006292_abnormal_olfactory_placode0.93987634
89MP0003755_abnormal_palate_morphology0.91369030
90MP0004185_abnormal_adipocyte_glucose0.90960266
91MP0004133_heterotaxia0.90826409
92MP0003115_abnormal_respiratory_system0.90523901
93MP0003315_abnormal_perineum_morphology0.90146362
94MP0000762_abnormal_tongue_morphology0.89717463
95MP0001849_ear_inflammation0.88284348
96MP0003699_abnormal_female_reproductive0.87852232
97MP0001119_abnormal_female_reproductive0.87107522
98MP0002161_abnormal_fertility/fecundity0.85778259
99MP0004272_abnormal_basement_membrane0.84604998
100MP0003195_calcinosis0.84552178
101MP0005389_reproductive_system_phenotype0.84032057
102MP0005384_cellular_phenotype0.83782372
103MP0000049_abnormal_middle_ear0.83674765
104MP0005501_abnormal_skin_physiology0.83623066
105MP0009053_abnormal_anal_canal0.82988305
106MP0003941_abnormal_skin_development0.82052916
107MP0001661_extended_life_span0.81710268
108MP0002938_white_spotting0.81319575
109MP0002697_abnormal_eye_size0.80740480
110MP0003937_abnormal_limbs/digits/tail_de0.80102642
111MP0002160_abnormal_reproductive_system0.79852647
112MP0002019_abnormal_tumor_incidence0.78267037
113MP0005621_abnormal_cell_physiology0.77915544
114MP0003936_abnormal_reproductive_system0.77166602
115MP0005623_abnormal_meninges_morphology0.76377529
116MP0001299_abnormal_eye_distance/0.75111036
117MP0002254_reproductive_system_inflammat0.75033779
118MP0002925_abnormal_cardiovascular_devel0.74686409
119MP0005367_renal/urinary_system_phenotyp0.73775402
120MP0000516_abnormal_urinary_system0.73775402
121MP0004043_abnormal_pH_regulation0.73469128
122MP0003935_abnormal_craniofacial_develop0.72878052
123MP0002116_abnormal_craniofacial_bone0.72465808
124MP0002098_abnormal_vibrissa_morphology0.72340371
125MP0001915_intracranial_hemorrhage0.72142714
126MP0002092_abnormal_eye_morphology0.71477896
127MP0003698_abnormal_male_reproductive0.70053134
128MP0000490_abnormal_crypts_of0.67951247
129MP0002111_abnormal_tail_morphology0.66828389
130MP0003300_gastrointestinal_ulcer0.66454410
131MP0005379_endocrine/exocrine_gland_phen0.65884664
132MP0002896_abnormal_bone_mineralization0.65470113
133MP0005248_abnormal_Harderian_gland0.65150149
134MP0000462_abnormal_digestive_system0.65049034
135MP0002909_abnormal_adrenal_gland0.63258637

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)4.48288487
2Hyperinsulinemic hypoglycemia (HP:0000825)4.07171304
3Ependymoma (HP:0002888)4.03745661
4Missing ribs (HP:0000921)4.02076050
5Hypoglycemic seizures (HP:0002173)3.58446561
6Volvulus (HP:0002580)3.51521201
7Colon cancer (HP:0003003)3.41014490
8Metaphyseal cupping (HP:0003021)3.16679907
9Medulloblastoma (HP:0002885)3.10288547
10Biliary tract neoplasm (HP:0100574)3.09083129
11Pancreatic islet-cell hyperplasia (HP:0004510)3.04958724
12Abnormality of endocrine pancreas physiology (HP:0012093)3.02923819
13Abnormality of the pancreatic islet cells (HP:0006476)3.02923819
14Selective tooth agenesis (HP:0001592)3.01878365
15Degeneration of anterior horn cells (HP:0002398)3.01750696
16Abnormality of the anterior horn cell (HP:0006802)3.01750696
17Astrocytoma (HP:0009592)3.00997278
18Abnormality of the astrocytes (HP:0100707)3.00997278
19Abnormal pancreas size (HP:0012094)2.95897589
20Embryonal renal neoplasm (HP:0011794)2.90885770
21Symptomatic seizures (HP:0011145)2.88310990
22Abnormal biliary tract morphology (HP:0012440)2.86706006
23Hypoglycemic coma (HP:0001325)2.71943265
24Neoplasm of the oral cavity (HP:0100649)2.70388205
25Glioma (HP:0009733)2.66288813
26Spinal muscular atrophy (HP:0007269)2.61231038
27Abnormal lung lobation (HP:0002101)2.55941696
28Broad distal phalanx of finger (HP:0009836)2.53467862
29Papillary thyroid carcinoma (HP:0002895)2.52809464
30Hand muscle atrophy (HP:0009130)2.49342113
31Meckel diverticulum (HP:0002245)2.47939901
32Rhabdomyosarcoma (HP:0002859)2.47926284
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.45196135
34Ovarian neoplasm (HP:0100615)2.44701374
35Prominent metopic ridge (HP:0005487)2.42208027
36Hyperglycemia (HP:0003074)2.35237286
37Absent radius (HP:0003974)2.34920279
38Abnormality of the preputium (HP:0100587)2.30860213
39Abnormality of chromosome segregation (HP:0002916)2.28865418
40Duplication of thumb phalanx (HP:0009942)2.28787713
41Abnormality of the ileum (HP:0001549)2.27423481
42Deviation of the thumb (HP:0009603)2.27198663
43Abnormal sex determination (HP:0012244)2.26325508
44Sex reversal (HP:0012245)2.26325508
45Gastrointestinal carcinoma (HP:0002672)2.25654350
46Malignant gastrointestinal tract tumors (HP:0006749)2.25654350
47Male infertility (HP:0003251)2.24269263
48Abnormality of chromosome stability (HP:0003220)2.23941994
49Truncal obesity (HP:0001956)2.20581627
50Impulsivity (HP:0100710)2.16073886
51Spastic diplegia (HP:0001264)2.15805857
52Abnormality of the metopic suture (HP:0005556)2.14506752
53Hypoplastic labia majora (HP:0000059)2.14244841
54Abnormality of the labia minora (HP:0012880)2.13079412
55Pelvic girdle muscle weakness (HP:0003749)2.12955806
56Sandal gap (HP:0001852)2.12777659
57Aplasia involving forearm bones (HP:0009822)2.11702659
58Absent forearm bone (HP:0003953)2.11702659
59Deep philtrum (HP:0002002)2.08839352
60Increased nuchal translucency (HP:0010880)2.08360577
61Duodenal stenosis (HP:0100867)2.08140738
62Small intestinal stenosis (HP:0012848)2.08140738
63Proximal placement of thumb (HP:0009623)2.06813045
64Agnosia (HP:0010524)2.06211135
65Abnormality of the calcaneus (HP:0008364)2.05546508
66Chromsome breakage (HP:0040012)2.02515161
67Neoplasm of the pancreas (HP:0002894)2.01194588
68Short humerus (HP:0005792)2.01085800
69Neoplasm of striated muscle (HP:0009728)2.00975594
70Hepatoblastoma (HP:0002884)2.00972831
71Abnormality of the duodenum (HP:0002246)1.99026875
72Cortical dysplasia (HP:0002539)1.99021810
73Intestinal atresia (HP:0011100)1.98098253
74Aplasia/hypoplasia of the humerus (HP:0006507)1.97271416
75Birth length less than 3rd percentile (HP:0003561)1.97047411
76Intestinal polyposis (HP:0200008)1.96971649
77Uterine neoplasm (HP:0010784)1.96084441
78Reticulocytopenia (HP:0001896)1.94953418
79Oligodactyly (hands) (HP:0001180)1.94826519
80Amaurosis fugax (HP:0100576)1.92882823
81Embryonal neoplasm (HP:0002898)1.92768001
82Atrophy/Degeneration involving motor neurons (HP:0007373)1.92652182
83Intestinal polyp (HP:0005266)1.92131917
84Gonadal dysgenesis (HP:0000133)1.90626928
85Macroorchidism (HP:0000053)1.90620045
86Obsessive-compulsive behavior (HP:0000722)1.89956043
87Facial hemangioma (HP:0000329)1.89436063
88Progressive external ophthalmoplegia (HP:0000590)1.88679475
89Horizontal nystagmus (HP:0000666)1.88082727
90Freckling (HP:0001480)1.87354691
91Orthostatic hypotension (HP:0001278)1.87221068
92Atresia of the external auditory canal (HP:0000413)1.85742701
93Prominent nose (HP:0000448)1.85337675
94Abnormality of the labia majora (HP:0012881)1.84950616
95Capillary hemangiomas (HP:0005306)1.84442310
96Gonadotropin excess (HP:0000837)1.83895668
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83824486
98Choanal atresia (HP:0000453)1.83665393
99Leiomyosarcoma (HP:0100243)1.83459199
100Uterine leiomyosarcoma (HP:0002891)1.83459199
101Ectopic kidney (HP:0000086)1.83426393
102Osteomalacia (HP:0002749)1.82089125
103Diastasis recti (HP:0001540)1.81998231
104Basal cell carcinoma (HP:0002671)1.81302226
105Nephroblastoma (Wilms tumor) (HP:0002667)1.81102029
106Myelodysplasia (HP:0002863)1.80709880
107Abnormality of the lower motor neuron (HP:0002366)1.80325397
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80155713
109Breast carcinoma (HP:0003002)1.79817126
110Anal stenosis (HP:0002025)1.79536546
111Large hands (HP:0001176)1.79181832
112Micronodular cirrhosis (HP:0001413)1.79078480
113Neoplasm of the small intestine (HP:0100833)1.78641821
114Rectal prolapse (HP:0002035)1.78582311
115Neoplasm of the rectum (HP:0100743)1.78351124
116Oligodactyly (HP:0012165)1.78007101
117Shoulder girdle muscle weakness (HP:0003547)1.77121581
118Shawl scrotum (HP:0000049)1.76086931
119Cafe-au-lait spot (HP:0000957)1.76043382
120Transposition of the great arteries (HP:0001669)1.75527921
121Abnormal connection of the cardiac segments (HP:0011545)1.75527921
122Abnormal ventriculo-arterial connection (HP:0011563)1.75527921
123Microvesicular hepatic steatosis (HP:0001414)1.73302493
124Resting tremor (HP:0002322)1.73282339
125High anterior hairline (HP:0009890)1.73092952
126Skull defect (HP:0001362)1.72859329
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.72468852
128Muscle fibrillation (HP:0010546)1.72357306
129Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72282830
130Insulin-resistant diabetes mellitus (HP:0000831)1.71987183
131Facial cleft (HP:0002006)1.71710324
132Tongue fasciculations (HP:0001308)1.71535685
133Delayed puberty (HP:0000823)1.71113171
134Abnormality of the musculature of the pelvis (HP:0001469)1.69446773
135Abnormality of the hip-girdle musculature (HP:0001445)1.69446773
136Broad thumb (HP:0011304)1.69108679
137Neoplasm of the colon (HP:0100273)1.68408385
138Testicular neoplasm (HP:0010788)1.68059367
139Broad palm (HP:0001169)1.67707784
140Abnormality of the carotid arteries (HP:0005344)1.67097041
141Abnormality of the fetal cardiovascular system (HP:0010948)1.64809928
142Abnormal umbilical cord blood vessels (HP:0011403)1.64809928
143Single umbilical artery (HP:0001195)1.64809928
144Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64150603
145Microglossia (HP:0000171)1.64118545
146Tubulointerstitial nephritis (HP:0001970)1.63555501
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.61327067
148Triphalangeal thumb (HP:0001199)1.60960589
149Overlapping toe (HP:0001845)1.60954568
150Generalized hypotonia (HP:0001290)1.60877274
151Horseshoe kidney (HP:0000085)1.60757734
152Abnormality of the dental root (HP:0006486)1.60211634
153Taurodontia (HP:0000679)1.60211634
154Abnormality of permanent molar morphology (HP:0011071)1.60211634
155Hypospadias (HP:0000047)1.60196464
156Partial duplication of thumb phalanx (HP:0009944)1.57231973
157Bifid tongue (HP:0010297)1.56898263
158Hypobetalipoproteinemia (HP:0003563)1.56876015
159Short nail (HP:0001799)1.56682806
160Type I transferrin isoform profile (HP:0003642)1.56382409
161Midline defect of the nose (HP:0004122)1.56262228
162Abnormality of the phalanges of the hallux (HP:0010057)1.55275252
163Enlarged penis (HP:0000040)1.54280737
164Radioulnar synostosis (HP:0002974)1.53214010
165Asymmetry of the thorax (HP:0001555)1.53154956
166Abnormality of dentin (HP:0010299)1.52837150
167Abnormal number of incisors (HP:0011064)1.52790435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.34990080
2PASK3.77959688
3CDC73.66874460
4WEE13.03783737
5SCYL22.80240184
6NEK22.42417266
7BRSK22.37616128
8PLK42.35083684
9BRD42.29163447
10EPHA22.28137186
11TAF12.25292854
12PBK2.14251193
13RPS6KB22.12280398
14WNK32.09991216
15CAMK1G2.09376251
16SMG11.96041306
17NEK11.89242146
18VRK21.84331078
19TTK1.82303922
20LATS11.82284500
21PKN21.78668381
22ACVR1B1.59817065
23EEF2K1.58697184
24CDK71.57980138
25PLK11.57774164
26ATR1.52246492
27LATS21.46367393
28BMX1.42803163
29EIF2AK31.42260232
30SRPK11.41062612
31PLK31.40417930
32INSRR1.40103108
33CHEK11.39773650
34FLT31.37130004
35TSSK61.35747487
36PRKD31.33205808
37AURKB1.31560648
38MAP3K21.29971404
39MST1R1.26854903
40MAP3K101.25744984
41PDK21.22223555
42PTK61.21664147
43MTOR1.21232730
44BUB11.20667902
45ATM1.19361522
46STK31.18747296
47TRIB31.15104436
48PDGFRA1.14953968
49CHEK21.14080207
50PAK41.13142774
51CDK41.13069555
52CDK61.09794936
53FRK1.08931255
54MAPK151.08512650
55ERBB41.05089346
56ALK1.02574054
57MAP3K81.00976947
58STK161.00916004
59BRSK11.00113097
60EIF2AK10.98323672
61DYRK30.96787298
62TGFBR10.96026962
63CDK20.94497783
64CDK90.93410744
65RPS6KA40.90990674
66MELK0.89949063
67CDK190.89309636
68STK38L0.88709410
69MET0.87824170
70PRKCI0.87106044
71TESK10.84500621
72STK100.83543599
73STK40.82894150
74CDC42BPA0.77629113
75FGFR10.77608450
76EIF2AK20.76585964
77KSR10.76077128
78MAP3K30.74822024
79TYRO30.74755084
80ERBB30.73376876
81AKT30.73039755
82MKNK10.72974493
83TRIM280.72283095
84NEK90.72092341
85CDK10.71345275
86PNCK0.70348781
87BRAF0.66500101
88PRKDC0.65944558
89CDK30.65846560
90CASK0.64904464
91PTK20.63970128
92HIPK20.63160959
93STK390.62537175
94PDGFRB0.62250909
95RIPK10.60833842
96TLK10.60644421
97RPS6KB10.58471808
98MKNK20.58013037
99FGFR20.56940396
100YES10.56801249
101CAMK1D0.56286573
102MST40.55377019
103MAPK140.53887105
104FGR0.52915953
105AURKA0.52647295
106MARK30.52620734
107MAPKAPK30.52570824
108ZAK0.50461312
109VRK10.48836046
110CHUK0.48585097
111PIM10.47911927
112CSNK1E0.47654046
113AKT10.46199467
114NUAK10.45613569
115MAP3K90.45399031
116CSNK2A20.44276046
117ICK0.44272318
118AKT20.42459070
119NME20.42064028
120PAK20.41365490
121MAP2K20.39784547
122CSNK1D0.39626118
123GSK3B0.38706271
124WNK10.38240136
125PDK30.36114386
126PDK40.36114386
127CDK80.36050147
128MAPK10.35209874
129CDK11A0.34080118
130FGFR40.33081839
131RET0.32404758
132IRAK30.31768982
133PRPF4B0.31617333
134DYRK1B0.31146983
135LRRK20.30855118
136FER0.30334492

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.86258060
2Mismatch repair_Homo sapiens_hsa034303.28776453
3DNA replication_Homo sapiens_hsa030303.20558079
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20487032
5RNA transport_Homo sapiens_hsa030133.15389367
6Cell cycle_Homo sapiens_hsa041102.67160412
7One carbon pool by folate_Homo sapiens_hsa006702.56938897
8Spliceosome_Homo sapiens_hsa030402.48751528
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46335230
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.35182442
11mRNA surveillance pathway_Homo sapiens_hsa030152.23046720
12Nucleotide excision repair_Homo sapiens_hsa034202.18229884
13Homologous recombination_Homo sapiens_hsa034402.12661622
14Non-homologous end-joining_Homo sapiens_hsa034501.98634756
15Protein export_Homo sapiens_hsa030601.95664981
16Selenocompound metabolism_Homo sapiens_hsa004501.95144525
17Fanconi anemia pathway_Homo sapiens_hsa034601.84145011
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.79635967
19Base excision repair_Homo sapiens_hsa034101.77775323
20RNA degradation_Homo sapiens_hsa030181.70509577
21Basal transcription factors_Homo sapiens_hsa030221.68542678
22RNA polymerase_Homo sapiens_hsa030201.51531625
23Systemic lupus erythematosus_Homo sapiens_hsa053221.47749831
24Antigen processing and presentation_Homo sapiens_hsa046121.44860339
25Viral carcinogenesis_Homo sapiens_hsa052031.41390662
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41086191
27Thyroid cancer_Homo sapiens_hsa052161.39451140
28p53 signaling pathway_Homo sapiens_hsa041151.37956649
29Steroid biosynthesis_Homo sapiens_hsa001001.35958055
30Pyruvate metabolism_Homo sapiens_hsa006201.29459269
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23429674
32Oocyte meiosis_Homo sapiens_hsa041141.22922984
33Pyrimidine metabolism_Homo sapiens_hsa002401.20156205
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19571943
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18722799
36N-Glycan biosynthesis_Homo sapiens_hsa005101.18589579
37Hippo signaling pathway_Homo sapiens_hsa043901.17548407
38Vitamin B6 metabolism_Homo sapiens_hsa007501.14234310
39Alcoholism_Homo sapiens_hsa050341.14023004
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12181345
41Sulfur relay system_Homo sapiens_hsa041221.10904341
42mTOR signaling pathway_Homo sapiens_hsa041501.10702776
43Adherens junction_Homo sapiens_hsa045201.08895066
44Small cell lung cancer_Homo sapiens_hsa052221.08455688
45MicroRNAs in cancer_Homo sapiens_hsa052061.06763984
46Lysine degradation_Homo sapiens_hsa003101.05957181
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05821838
48TGF-beta signaling pathway_Homo sapiens_hsa043500.99498548
49Carbon metabolism_Homo sapiens_hsa012000.96927363
50HTLV-I infection_Homo sapiens_hsa051660.96145741
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94382677
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93927289
53Epstein-Barr virus infection_Homo sapiens_hsa051690.93865423
54Propanoate metabolism_Homo sapiens_hsa006400.91371111
55Type II diabetes mellitus_Homo sapiens_hsa049300.91110811
56Tight junction_Homo sapiens_hsa045300.86267615
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.83258503
58Herpes simplex infection_Homo sapiens_hsa051680.78461360
59Type I diabetes mellitus_Homo sapiens_hsa049400.78048173
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76811320
61Endometrial cancer_Homo sapiens_hsa052130.76237099
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75825011
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75816231
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75454767
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74812284
66Prostate cancer_Homo sapiens_hsa052150.74699103
67Chronic myeloid leukemia_Homo sapiens_hsa052200.72724099
68Hedgehog signaling pathway_Homo sapiens_hsa043400.72512401
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72229191
70Basal cell carcinoma_Homo sapiens_hsa052170.72169643
71Bladder cancer_Homo sapiens_hsa052190.71226789
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69582604
73Colorectal cancer_Homo sapiens_hsa052100.69579722
74Arginine biosynthesis_Homo sapiens_hsa002200.67805010
75Proteasome_Homo sapiens_hsa030500.67536950
76Dorso-ventral axis formation_Homo sapiens_hsa043200.65469300
77Purine metabolism_Homo sapiens_hsa002300.63301514
78Glucagon signaling pathway_Homo sapiens_hsa049220.59980638
79Insulin resistance_Homo sapiens_hsa049310.59113841
80Pentose phosphate pathway_Homo sapiens_hsa000300.58609591
81Folate biosynthesis_Homo sapiens_hsa007900.58433714
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58172073
83Insulin secretion_Homo sapiens_hsa049110.57190750
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56586100
85Proteoglycans in cancer_Homo sapiens_hsa052050.56566523
86Legionellosis_Homo sapiens_hsa051340.55383593
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54947508
88Melanoma_Homo sapiens_hsa052180.54733232
89Notch signaling pathway_Homo sapiens_hsa043300.54338456
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54085368
91Fatty acid elongation_Homo sapiens_hsa000620.54041951
92Prolactin signaling pathway_Homo sapiens_hsa049170.52806050
93Fatty acid metabolism_Homo sapiens_hsa012120.52267604
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51085622
95FoxO signaling pathway_Homo sapiens_hsa040680.50432152
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50209914
97Galactose metabolism_Homo sapiens_hsa000520.50173748
98ErbB signaling pathway_Homo sapiens_hsa040120.49689995
99Non-small cell lung cancer_Homo sapiens_hsa052230.48823301
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47992224
101Pathways in cancer_Homo sapiens_hsa052000.47827062
102Arginine and proline metabolism_Homo sapiens_hsa003300.47502488
103Wnt signaling pathway_Homo sapiens_hsa043100.46035635
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45285041
105AMPK signaling pathway_Homo sapiens_hsa041520.44600049
106beta-Alanine metabolism_Homo sapiens_hsa004100.42236753
107Ribosome_Homo sapiens_hsa030100.41942968
108Estrogen signaling pathway_Homo sapiens_hsa049150.41172825
109Fatty acid biosynthesis_Homo sapiens_hsa000610.40287398
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.40185311
111Focal adhesion_Homo sapiens_hsa045100.39361178
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38988215
113Thyroid hormone synthesis_Homo sapiens_hsa049180.35950748
114Pancreatic cancer_Homo sapiens_hsa052120.35437121
115Inositol phosphate metabolism_Homo sapiens_hsa005620.35140297
116Insulin signaling pathway_Homo sapiens_hsa049100.34071494
117Renal cell carcinoma_Homo sapiens_hsa052110.32920778
118Vitamin digestion and absorption_Homo sapiens_hsa049770.31061477
119Phenylalanine metabolism_Homo sapiens_hsa003600.30453817
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30147358
121Hepatitis B_Homo sapiens_hsa051610.29221884
122Apoptosis_Homo sapiens_hsa042100.28807489
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.28694260
124Prion diseases_Homo sapiens_hsa050200.28439770
125Acute myeloid leukemia_Homo sapiens_hsa052210.26867541
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26815435
127ECM-receptor interaction_Homo sapiens_hsa045120.22220180
128Biosynthesis of amino acids_Homo sapiens_hsa012300.22173097
129Influenza A_Homo sapiens_hsa051640.21950048
130Circadian rhythm_Homo sapiens_hsa047100.21765549
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20427313
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.19453446

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