JAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.54494659
2cell-substrate junction assembly (GO:0007044)4.70025347
3keratinocyte proliferation (GO:0043616)4.19184317
4establishment of tissue polarity (GO:0007164)4.18184741
5establishment of planar polarity (GO:0001736)4.18184741
6lateral sprouting from an epithelium (GO:0060601)4.00248896
7bundle of His cell to Purkinje myocyte communication (GO:0086069)3.93711788
8cell adhesion mediated by integrin (GO:0033627)3.81641326
9glomerulus development (GO:0032835)3.67053185
10* Notch signaling involved in heart development (GO:0061314)3.63809943
11endocardial cushion morphogenesis (GO:0003203)3.61663886
12epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.60904961
13hemidesmosome assembly (GO:0031581)3.52666601
14gap junction assembly (GO:0016264)3.47099308
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44100062
16chondrocyte proliferation (GO:0035988)3.40605267
17skin morphogenesis (GO:0043589)3.40095523
18mesodermal cell differentiation (GO:0048333)3.37251075
19mesenchyme morphogenesis (GO:0072132)3.34831942
20regulation of keratinocyte proliferation (GO:0010837)3.31735879
21atrioventricular valve morphogenesis (GO:0003181)3.26344612
22cardiac epithelial to mesenchymal transition (GO:0060317)3.23506770
23establishment of skin barrier (GO:0061436)3.20885990
24metanephric mesenchyme development (GO:0072075)3.16291235
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.16027344
26axon extension involved in axon guidance (GO:0048846)3.16027344
27renal filtration (GO:0097205)3.13265873
28basement membrane organization (GO:0071711)3.10533294
29coronary vasculature morphogenesis (GO:0060977)3.05726340
30fibroblast migration (GO:0010761)3.05520471
31polarized epithelial cell differentiation (GO:0030859)3.03320532
32surfactant homeostasis (GO:0043129)3.01644781
33cell proliferation involved in kidney development (GO:0072111)2.97119871
34* neuronal stem cell maintenance (GO:0097150)2.96910935
35regulation of apoptotic process involved in morphogenesis (GO:1902337)2.95072996
36regulation of somitogenesis (GO:0014807)2.94640788
37negative regulation of anoikis (GO:2000811)2.93341600
38wound healing, spreading of epidermal cells (GO:0035313)2.93286288
39* heart valve morphogenesis (GO:0003179)2.91873484
40negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.89341827
41branching involved in salivary gland morphogenesis (GO:0060445)2.89286382
42regulation of water loss via skin (GO:0033561)2.89265972
43mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.88848163
44vascular endothelial growth factor signaling pathway (GO:0038084)2.88542688
45kidney mesenchyme development (GO:0072074)2.87877018
46notochord development (GO:0030903)2.82276975
47regulation of transforming growth factor beta2 production (GO:0032909)2.81532005
48retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81368850
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81353503
50semaphorin-plexin signaling pathway (GO:0071526)2.80963892
51cochlea morphogenesis (GO:0090103)2.80720188
52adherens junction assembly (GO:0034333)2.80663072
53negative regulation of epidermis development (GO:0045683)2.80020647
54regulation of establishment of planar polarity (GO:0090175)2.79361191
55positive regulation of p38MAPK cascade (GO:1900745)2.77998705
56negative regulation of chondrocyte differentiation (GO:0032331)2.77566920
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76020126
58ganglion development (GO:0061548)2.75641352
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.74356390
60regulation of macrophage cytokine production (GO:0010935)2.74177856
61collagen fibril organization (GO:0030199)2.73807449
62extracellular matrix disassembly (GO:0022617)2.73562417
63regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.72779120
64intermediate filament organization (GO:0045109)2.72698111
65* cell surface receptor signaling pathway involved in heart development (GO:0061311)2.71446390
66growth hormone receptor signaling pathway (GO:0060396)2.71103295
67regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.70467230
68camera-type eye morphogenesis (GO:0048593)2.69328321
69cell proliferation involved in metanephros development (GO:0072203)2.69240981
70regulation of axon extension involved in axon guidance (GO:0048841)2.67503258
71regulation of cardioblast differentiation (GO:0051890)2.67449435
72focal adhesion assembly (GO:0048041)2.67168967
73cell-substrate adherens junction assembly (GO:0007045)2.67168967
74suckling behavior (GO:0001967)2.66840574
75cell differentiation involved in metanephros development (GO:0072202)2.65309877
76apical protein localization (GO:0045176)2.65123455
77neuron fate commitment (GO:0048663)2.64314577
78endodermal cell differentiation (GO:0035987)2.63836913
79neuron remodeling (GO:0016322)2.63194394
80G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.62990190
81heart valve formation (GO:0003188)2.60841290
82limb bud formation (GO:0060174)2.60806509
83hippo signaling (GO:0035329)2.60693323
84adherens junction organization (GO:0034332)2.60659631
85ventricular trabecula myocardium morphogenesis (GO:0003222)2.60418222
86asymmetric protein localization (GO:0008105)2.60228327
87glomerular filtration (GO:0003094)2.60198081
88chemical homeostasis within a tissue (GO:0048875)2.59872253
89substrate-dependent cell migration (GO:0006929)2.59524861
90negative regulation of oligodendrocyte differentiation (GO:0048715)2.59517070
91negative regulation of axon extension involved in axon guidance (GO:0048843)2.59177957
92regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.59008390
93negative regulation of catenin import into nucleus (GO:0035414)2.58693253
94epidermis development (GO:0008544)2.58250449
95lens fiber cell development (GO:0070307)2.58088639
96regulation of endothelial cell chemotaxis (GO:2001026)2.57231962
97collagen metabolic process (GO:0032963)2.56954551
98cell migration involved in sprouting angiogenesis (GO:0002042)2.56829157
99negative regulation of keratinocyte proliferation (GO:0010839)2.56149844
100cell junction assembly (GO:0034329)2.56048003
101nephron tubule formation (GO:0072079)2.56000003
102collagen catabolic process (GO:0030574)2.55918497
103epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55507906
104protein localization to cell surface (GO:0034394)2.54964285
105regulation of integrin activation (GO:0033623)2.54872562
106epithelial cell-cell adhesion (GO:0090136)2.54869581
107wound healing, spreading of cells (GO:0044319)2.54193475
108bone remodeling (GO:0046849)2.53737049
109endothelial cell morphogenesis (GO:0001886)2.51965420
110positive regulation of macrophage cytokine production (GO:0060907)2.51616004
111endothelial cell chemotaxis (GO:0035767)2.50965917
112post-anal tail morphogenesis (GO:0036342)2.50946452
113mesonephric tubule development (GO:0072164)2.50093128
114non-canonical Wnt signaling pathway (GO:0035567)2.49905526
115* mesenchymal cell development (GO:0014031)2.48340589
116positive regulation of astrocyte differentiation (GO:0048711)2.48187081
117regulation of chemokine-mediated signaling pathway (GO:0070099)2.47477008
118positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47182585
119lens morphogenesis in camera-type eye (GO:0002089)2.45786509
120pathway-restricted SMAD protein phosphorylation (GO:0060389)2.45230413
121ectoderm development (GO:0007398)2.45049712
122regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44881129
123ureteric bud development (GO:0001657)2.44378704
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44121342
125paraxial mesoderm development (GO:0048339)2.43588490
126positive regulation of cellular amide metabolic process (GO:0034250)2.42819531
127spinal cord association neuron differentiation (GO:0021527)2.42518770
128cell junction organization (GO:0034330)2.42173089
129multicellular organismal macromolecule metabolic process (GO:0044259)2.41337506
130epithelial to mesenchymal transition (GO:0001837)2.41218883
131mesonephric epithelium development (GO:0072163)2.39241321
132modulation by symbiont of host defense response (GO:0052031)2.38147859
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.38147859
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.38147859
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.38147859
136modulation by symbiont of host immune response (GO:0052553)2.38147859
137positive regulation by symbiont of host defense response (GO:0052509)2.38147859
138positive regulation of epithelial to mesenchymal transition (GO:0010718)2.36574296
139regulation of mesonephros development (GO:0061217)2.36267064
140negative regulation of cartilage development (GO:0061037)2.36166433
141outer ear morphogenesis (GO:0042473)2.34329427
142mammary gland development (GO:0030879)2.34084914
143* neural crest cell development (GO:0014032)2.33151586
144negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.32787526
145myelin assembly (GO:0032288)2.32526030
146muscle cell migration (GO:0014812)2.30868712
147* cardiac septum morphogenesis (GO:0060411)2.29554505
148ventricular septum morphogenesis (GO:0060412)2.29224710
149lymph vessel development (GO:0001945)2.28810478
150glomerular visceral epithelial cell development (GO:0072015)2.27553556
151regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.27518541
152positive regulation of monocyte chemotaxis (GO:0090026)2.25914615
153regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.25285774
154sequestering of extracellular ligand from receptor (GO:0035581)2.25276177
155cellular response to vitamin (GO:0071295)2.25171297
156myoblast migration (GO:0051451)2.24729348
157bone trabecula formation (GO:0060346)2.23644437
158cellular response to growth hormone stimulus (GO:0071378)2.23218266
159positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.22277743
160planar cell polarity pathway involved in neural tube closure (GO:0090179)2.22064994
161smooth muscle tissue development (GO:0048745)2.22000860
162positive regulation of endothelial cell apoptotic process (GO:2000353)2.21909516
163lymphangiogenesis (GO:0001946)2.21392704
164regulation of mononuclear cell migration (GO:0071675)2.21257101
165regulation of glomerulus development (GO:0090192)2.20903434
166* kidney epithelium development (GO:0072073)2.19069677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TP63_17297297_ChIP-ChIP_HaCaT_Human6.57592237
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.19661383
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.49823883
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.00059650
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.91222209
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.82463871
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.71542304
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.43560127
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40382237
10* CJUN_26792858_Chip-Seq_BT549_Human2.33497465
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27848629
12* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.25307251
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17941840
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17941840
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16053505
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.11106629
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00140261
18CLOCK_20551151_ChIP-Seq_293T_Human2.00095491
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99141504
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98764183
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.97031903
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.93317819
23* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93307223
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.91847027
25* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.89965095
26* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.89965095
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86433774
28* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84014261
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80923071
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.80042388
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74572239
32* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.71871355
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71676479
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70715985
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.68939997
36SOX9_24532713_ChIP-Seq_HFSC_Mouse1.64329437
37* TP53_18474530_ChIP-ChIP_U2OS_Human1.61882617
38* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61846150
39* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61030985
40AHR_22903824_ChIP-Seq_MCF-7_Human1.59660232
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58860309
42* SOX2_20726797_ChIP-Seq_SW620_Human1.58811945
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.58082661
44VDR_24787735_ChIP-Seq_THP-1_Human1.56678322
45BRD4_25478319_ChIP-Seq_HGPS_Human1.55839383
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.53516476
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.51088823
48* FOXO3_23340844_ChIP-Seq_DLD1_Human1.48358484
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47882208
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45961325
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.44110426
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.42588778
53* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42588719
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39512371
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39512371
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39512371
57* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37140505
58* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37140505
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37089712
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32903981
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32593630
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31190364
63* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.31133399
64SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30152928
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28392042
66TP53_16413492_ChIP-PET_HCT116_Human1.28183445
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26139283
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26115960
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25114676
70* UBF1/2_26484160_Chip-Seq_HMECs_Human1.24289860
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24146565
72ZNF263_19887448_ChIP-Seq_K562_Human1.23549745
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22833377
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.22144182
75* TP63_23658742_ChIP-Seq_EP156T_Human1.21986251
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21713457
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21516088
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20913878
79GBX2_23144817_ChIP-Seq_PC3_Human1.19767485
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19321702
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.19271750
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.19247501
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16632737
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15558637
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13941500
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13889746
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.13298484
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12101158
89SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11197061
90* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09464364
91EZH2_22144423_ChIP-Seq_EOC_Human1.08455972
92KLF5_25053715_ChIP-Seq_YYC3_Human1.06732601
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06540375
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.06475060
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05618439
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.05494861
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05388374
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05296857
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04963772
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04542574
101* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02801152
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02556602
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02538116
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02506810
105RXR_22108803_ChIP-Seq_LS180_Human1.01958726
106* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01635642
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.00753207
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00241586
109TAF15_26573619_Chip-Seq_HEK293_Human1.00179424
110* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00086331
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99885813
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98829894
113ISL1_27105846_Chip-Seq_CPCs_Mouse0.97310380
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97307475
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97050735
116* RNF2_27304074_Chip-Seq_ESCs_Mouse0.96917952
117* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96840479
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96032937
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95796101
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95077749
121* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93117508
122* GATA3_24758297_ChIP-Seq_MCF-7_Human0.92040837
123* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90631857
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89776378
125* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89207403
126SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88093099
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87834619
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87729549
129* GATA4_25053715_ChIP-Seq_YYC3_Human0.87435657
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.87127438
131AR_21572438_ChIP-Seq_LNCaP_Human0.86717562
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.86159041
133* TBX20_22328084_ChIP-Seq_HEART_Mouse0.84241390
134* TBX20_22080862_ChIP-Seq_HEART_Mouse0.84241390
135EED_16625203_ChIP-ChIP_MESCs_Mouse0.83312486
136* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.80667553
137* RING1B_27294783_Chip-Seq_NPCs_Mouse0.80354262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.25807227
2MP0002009_preneoplasia3.15957640
3MP0003941_abnormal_skin_development3.09087038
4MP0003705_abnormal_hypodermis_morpholog2.68232607
5MP0004272_abnormal_basement_membrane2.64146210
6MP0005275_abnormal_skin_tensile2.59874683
7MP0010030_abnormal_orbit_morphology2.44386882
8MP0000566_synostosis2.43018605
9MP0000537_abnormal_urethra_morphology2.35977320
10MP0009053_abnormal_anal_canal2.29996770
11MP0003566_abnormal_cell_adhesion2.25084714
12MP0003279_aneurysm2.23437861
13MP0001958_emphysema2.00920261
14MP0009384_cardiac_valve_regurgitation1.97788690
15MP0005409_darkened_coat_color1.96393481
16MP0005377_hearing/vestibular/ear_phenot1.86027331
17MP0003878_abnormal_ear_physiology1.86027331
18MP0002138_abnormal_hepatobiliary_system1.85403940
19MP0001879_abnormal_lymphatic_vessel1.83116998
20MP0005171_absent_coat_pigmentation1.80791839
21MP0005084_abnormal_gallbladder_morpholo1.73668034
22MP0003942_abnormal_urinary_system1.71366340
23MP0010368_abnormal_lymphatic_system1.68063279
24MP0001346_abnormal_lacrimal_gland1.65724714
25MP0002282_abnormal_trachea_morphology1.65334010
26MP0005257_abnormal_intraocular_pressure1.61725809
27MP0005508_abnormal_skeleton_morphology1.61546058
28MP0002295_abnormal_pulmonary_circulatio1.58828024
29MP0003950_abnormal_plasma_membrane1.57571358
30MP0005623_abnormal_meninges_morphology1.57283993
31MP0000383_abnormal_hair_follicle1.54168372
32MP0009250_abnormal_appendicular_skeleto1.54137342
33* MP0000767_abnormal_smooth_muscle1.53870939
34MP0005503_abnormal_tendon_morphology1.53461465
35MP0003453_abnormal_keratinocyte_physiol1.52726539
36MP0002877_abnormal_melanocyte_morpholog1.52044784
37MP0010352_gastrointestinal_tract_polyps1.52033016
38MP0002006_tumorigenesis1.51103507
39MP0002254_reproductive_system_inflammat1.50706452
40MP0002234_abnormal_pharynx_morphology1.49501730
41MP0000762_abnormal_tongue_morphology1.48728911
42MP0005248_abnormal_Harderian_gland1.48270755
43MP0002060_abnormal_skin_morphology1.46794276
44MP0003828_pulmonary_edema1.46540157
45MP0006054_spinal_hemorrhage1.45917410
46MP0005023_abnormal_wound_healing1.43582349
47MP0000534_abnormal_ureter_morphology1.42135036
48MP0004858_abnormal_nervous_system1.41823434
49MP0001299_abnormal_eye_distance/1.39352187
50MP0003091_abnormal_cell_migration1.38959387
51MP0008789_abnormal_olfactory_epithelium1.38791672
52MP0010678_abnormal_skin_adnexa1.36224682
53MP0002249_abnormal_larynx_morphology1.35708349
54MP0009278_abnormal_bone_marrow1.35584767
55MP0002098_abnormal_vibrissa_morphology1.33728969
56MP0002166_altered_tumor_susceptibility1.32733210
57MP0003385_abnormal_body_wall1.32252628
58MP0003937_abnormal_limbs/digits/tail_de1.31659342
59MP0000778_abnormal_nervous_system1.31485232
60MP0000579_abnormal_nail_morphology1.28499945
61MP0000049_abnormal_middle_ear1.27465310
62MP0003448_altered_tumor_morphology1.27145380
63MP0000733_abnormal_muscle_development1.27124032
64MP0003755_abnormal_palate_morphology1.26858992
65MP0002697_abnormal_eye_size1.26831505
66MP0010234_abnormal_vibrissa_follicle1.21617242
67MP0003115_abnormal_respiratory_system1.20912440
68MP0003136_yellow_coat_color1.19545503
69MP0005076_abnormal_cell_differentiation1.18817646
70MP0010771_integument_phenotype1.17224502
71MP0005390_skeleton_phenotype1.16983299
72MP0005501_abnormal_skin_physiology1.14939794
73MP0002896_abnormal_bone_mineralization1.14620520
74MP0002233_abnormal_nose_morphology1.13654070
75* MP0002928_abnormal_bile_duct1.11202025
76* MP0005197_abnormal_uvea_morphology1.09477485
77* MP0002092_abnormal_eye_morphology1.07673237
78MP0000462_abnormal_digestive_system1.04366079
79MP0002277_abnormal_respiratory_mucosa1.02787970
80MP0000428_abnormal_craniofacial_morphol1.02750406
81MP0000163_abnormal_cartilage_morphology1.02479986
82MP0003724_increased_susceptibility_to1.02475021
83MP0003315_abnormal_perineum_morphology1.00994239
84* MP0001286_abnormal_eye_development0.99874637
85MP0005187_abnormal_penis_morphology0.99657246
86MP0002111_abnormal_tail_morphology0.98967051
87MP0001293_anophthalmia0.98596755
88MP0000432_abnormal_head_morphology0.98002912
89MP0002938_white_spotting0.95718358
90MP0000647_abnormal_sebaceous_gland0.95336163
91MP0000516_abnormal_urinary_system0.94032935
92MP0005367_renal/urinary_system_phenotyp0.94032935
93MP0000377_abnormal_hair_follicle0.94008369
94MP0002133_abnormal_respiratory_system0.93177901
95MP0005388_respiratory_system_phenotype0.93177901
96MP0001849_ear_inflammation0.92917052
97MP0002115_abnormal_skeleton_extremities0.92855532
98MP0005499_abnormal_olfactory_system0.92728392
99MP0005394_taste/olfaction_phenotype0.92728392
100* MP0001614_abnormal_blood_vessel0.92699929
101MP0000751_myopathy0.91909014
102MP0002932_abnormal_joint_morphology0.91885579
103MP0005595_abnormal_vascular_smooth0.90522041
104* MP0001915_intracranial_hemorrhage0.89791747
105MP0003935_abnormal_craniofacial_develop0.89029108
106MP0001533_abnormal_skeleton_physiology0.88903232
107MP0001175_abnormal_lung_morphology0.88858438
108MP0002108_abnormal_muscle_morphology0.88717180
109MP0002116_abnormal_craniofacial_bone0.87763869
110MP0002796_impaired_skin_barrier0.86768363
111* MP0002925_abnormal_cardiovascular_devel0.86349861
112MP0002177_abnormal_outer_ear0.86039218
113* MP0003943_abnormal_hepatobiliary_system0.85682443
114MP0005083_abnormal_biliary_tract0.85545342
115MP0002109_abnormal_limb_morphology0.84530932
116MP0000858_altered_metastatic_potential0.84517764
117MP0005164_abnormal_response_to0.83730348
118MP0002089_abnormal_postnatal_growth/wei0.83211933
119MP0006138_congestive_heart_failure0.82963794
120MP0001243_abnormal_dermal_layer0.82920662
121MP0000627_abnormal_mammary_gland0.82488563
122MP0000467_abnormal_esophagus_morphology0.82406091
123MP0001216_abnormal_epidermal_layer0.80659873
124MP0000613_abnormal_salivary_gland0.79184547
125MP0002113_abnormal_skeleton_development0.79079564
126MP0004883_abnormal_blood_vessel0.78991776
127MP0005397_hematopoietic_system_phenotyp0.78794727
128* MP0005193_abnormal_anterior_eye0.73850269
129MP0002095_abnormal_skin_pigmentation0.70486214
130MP0001340_abnormal_eyelid_morphology0.69867752
131MP0002084_abnormal_developmental_patter0.69195929
132MP0004264_abnormal_extraembryonic_tissu0.67776540
133MP0003119_abnormal_digestive_system0.66407024
134* MP0003861_abnormal_nervous_system0.64956784
135MP0000569_abnormal_digit_pigmentation0.63002133
136MP0000013_abnormal_adipose_tissue0.61841190

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)4.83240596
2Plantar hyperkeratosis (HP:0007556)4.04047707
3Abnormality of nail color (HP:0100643)3.53231417
4Premature rupture of membranes (HP:0001788)3.42265281
5Vascular tortuosity (HP:0004948)3.34106288
6Atrophic scars (HP:0001075)3.10930435
7Aortic aneurysm (HP:0004942)3.01367344
8Pigmentary retinal degeneration (HP:0001146)2.93368628
9Aortic dissection (HP:0002647)2.79395837
10Nail dystrophy (HP:0008404)2.76731292
11Abnormality of the nasal septum (HP:0000419)2.76668469
12Palmoplantar hyperkeratosis (HP:0000972)2.75421196
13* Chorioretinal atrophy (HP:0000533)2.73169191
14Alopecia of scalp (HP:0002293)2.69110422
15Palmar hyperkeratosis (HP:0010765)2.67670912
16Short nail (HP:0001799)2.65845593
17Selective tooth agenesis (HP:0001592)2.65456709
18Aplasia of the phalanges of the hand (HP:0009802)2.65210667
19Aplasia involving bones of the extremities (HP:0009825)2.65210667
20Aplasia involving bones of the upper limbs (HP:0009823)2.65210667
21Lip pit (HP:0100267)2.60918066
22Hypoplasia of the iris (HP:0007676)2.52919344
23Syringomyelia (HP:0003396)2.51662188
24Spinal cord lesions (HP:0100561)2.51662188
25Protrusio acetabuli (HP:0003179)2.50635256
26Thick nail (HP:0001805)2.49777218
27Abnormal pancreas size (HP:0012094)2.47540506
28Milia (HP:0001056)2.45265691
29Mixed hearing impairment (HP:0000410)2.44469546
30Vitreoretinal degeneration (HP:0000655)2.43224642
31Synostosis involving the elbow (HP:0003938)2.43077168
32Humeroradial synostosis (HP:0003041)2.43077168
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38939077
34Shallow orbits (HP:0000586)2.38797575
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.35934496
36Osteolytic defects of the hand bones (HP:0009699)2.35934496
37Unilateral renal agenesis (HP:0000122)2.26384125
38Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.25070918
39Neonatal short-limb short stature (HP:0008921)2.24602058
40Hypoplasia of dental enamel (HP:0006297)2.24404357
41Abnormality of incisor morphology (HP:0011063)2.23795824
42Fragile skin (HP:0001030)2.23771396
43Abnormality of dentin (HP:0010299)2.22566833
44Wormian bones (HP:0002645)2.22339512
45Dilatation of the ascending aorta (HP:0005111)2.22103890
46Arterial tortuosity (HP:0005116)2.21832959
47Right ventricular cardiomyopathy (HP:0011663)2.21775354
48Split foot (HP:0001839)2.18178588
49Follicular hyperkeratosis (HP:0007502)2.17170678
50Abnormality of the distal phalanges of the toes (HP:0010182)2.17006605
51Epiphyseal dysplasia (HP:0002656)2.15948568
52Fused cervical vertebrae (HP:0002949)2.15342928
53* Pulmonary artery stenosis (HP:0004415)2.12408637
54Tibial bowing (HP:0002982)2.11129087
55Peritonitis (HP:0002586)2.10467127
56Nuclear cataract (HP:0100018)2.10432614
57Coronal craniosynostosis (HP:0004440)2.08298074
58Morphological abnormality of the middle ear (HP:0008609)2.07608123
59Broad face (HP:0000283)2.06864173
60Shawl scrotum (HP:0000049)2.06449976
61Soft skin (HP:0000977)2.05972208
62Aplasia cutis congenita (HP:0001057)2.04500027
63Ridged nail (HP:0001807)2.03775988
64Subacute progressive viral hepatitis (HP:0006572)2.03531686
65Potter facies (HP:0002009)2.02722575
66Facial shape deformation (HP:0011334)2.02722575
67Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.02018486
68Vertebral hypoplasia (HP:0008417)2.02018486
69Mitral valve prolapse (HP:0001634)2.01319738
70Hypotrichosis (HP:0001006)2.01080705
71Short hallux (HP:0010109)2.00452385
72Abnormal vertebral ossification (HP:0100569)1.99555564
73Camptodactyly of toe (HP:0001836)1.99398890
74Cerebral aneurysm (HP:0004944)1.98450297
75Pili torti (HP:0003777)1.97280793
76Tarsal synostosis (HP:0008368)1.97258670
77Absent eyelashes (HP:0000561)1.97167387
78Wide anterior fontanel (HP:0000260)1.96139191
79Anomalous pulmonary venous return (HP:0010772)1.95898607
80Absent frontal sinuses (HP:0002688)1.95887170
81Increased connective tissue (HP:0009025)1.95861751
82Bicornuate uterus (HP:0000813)1.95801171
83Abnormality of the pulmonary veins (HP:0011718)1.94178516
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.93926895
85Abnormality of molar morphology (HP:0011070)1.93278727
86Abnormality of molar (HP:0011077)1.93278727
87Bell-shaped thorax (HP:0001591)1.93160102
88Synostosis involving bones of the feet (HP:0009140)1.92750004
89Synostosis involving bones of the lower limbs (HP:0009138)1.92750004
90Ankyloglossia (HP:0010296)1.92158202
91Myelomeningocele (HP:0002475)1.91583564
92Cutaneous syndactyly (HP:0012725)1.89521275
93Hypoplastic labia majora (HP:0000059)1.86089847
94Cutaneous finger syndactyly (HP:0010554)1.86005783
95Asymmetry of the thorax (HP:0001555)1.85981440
96Absent eyebrow (HP:0002223)1.85700940
97Onycholysis (HP:0001806)1.85361409
98Abnormality of the dental root (HP:0006486)1.84955893
99Taurodontia (HP:0000679)1.84955893
100Abnormality of permanent molar morphology (HP:0011071)1.84955893
101Hypodontia (HP:0000668)1.84955745
102Hypoplastic ischia (HP:0003175)1.84845588
103Woolly hair (HP:0002224)1.84791648
104Natal tooth (HP:0000695)1.83185327
105Bronchomalacia (HP:0002780)1.82575078
106Advanced eruption of teeth (HP:0006288)1.81910124
107Sparse scalp hair (HP:0002209)1.81233491
108Urethral obstruction (HP:0000796)1.81163127
109Oligodontia (HP:0000677)1.80896078
110Abnormality of the labia majora (HP:0012881)1.80761029
111Pterygium (HP:0001059)1.80263469
112Bladder diverticulum (HP:0000015)1.79216439
113Abnormality of the lacrimal duct (HP:0011481)1.78857358
114Abnormality of the middle phalanges of the toes (HP:0010183)1.78542090
115Absent toe (HP:0010760)1.78508398
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.77906414
117Short 4th metacarpal (HP:0010044)1.77906414
118Synostosis of carpal bones (HP:0005048)1.77776476
119Esophageal atresia (HP:0002032)1.77762208
120* Vertebral arch anomaly (HP:0008438)1.77622648
121Sprengel anomaly (HP:0000912)1.77092467
122Laryngomalacia (HP:0001601)1.76183157
123Abnormality of the pubic bones (HP:0003172)1.75627747
124Aplasia/Hypoplasia of the hallux (HP:0008362)1.75557050
125Abnormality of secondary sexual hair (HP:0009888)1.75017052
126Abnormality of the axillary hair (HP:0100134)1.75017052
127Mitral regurgitation (HP:0001653)1.74708145
128Vertebral clefting (HP:0008428)1.73557214
129Abnormal hair laboratory examination (HP:0003328)1.73123699
130Hematochezia (HP:0002573)1.72934004
131Stomach cancer (HP:0012126)1.72462302
132Femoral bowing (HP:0002980)1.71991634
133Anonychia (HP:0001798)1.71474299
134Ulnar bowing (HP:0003031)1.70830534
135Abnormality of the ischium (HP:0003174)1.70677553
136Abnormality of the nasolacrimal system (HP:0000614)1.69702839
137Hepatoblastoma (HP:0002884)1.69627066
138Abnormal blistering of the skin (HP:0008066)1.69471566
139Spinal rigidity (HP:0003306)1.68406986
140Midline defect of the nose (HP:0004122)1.67719833
141Spondylolisthesis (HP:0003302)1.66529129
142Abnormal ossification of hand bones (HP:0005921)1.65715878
143Bicuspid aortic valve (HP:0001647)1.64748705
144Xerostomia (HP:0000217)1.64129380
145Flat acetabular roof (HP:0003180)1.63970185
146Broad metatarsal (HP:0001783)1.63813212
147Ankle contracture (HP:0006466)1.63785605
148Elbow flexion contracture (HP:0002987)1.63598144
149Bilateral microphthalmos (HP:0007633)1.63572181
150Popliteal pterygium (HP:0009756)1.62930145
151Abnormality of the lower motor neuron (HP:0002366)1.62699856
152Limited hip movement (HP:0008800)1.62160977
153Abnormality of the dental pulp (HP:0006479)1.61696705
154Focal segmental glomerulosclerosis (HP:0000097)1.59805737
155Abnormality of oral frenula (HP:0000190)1.58239300
156Corneal erosion (HP:0200020)1.57988545
157Genu recurvatum (HP:0002816)1.57570317
158Tetraparesis (HP:0002273)1.53951052
159Aortic regurgitation (HP:0001659)1.53340839
160Neurofibrillary tangles (HP:0002185)1.52870054
161Blue irides (HP:0000635)1.52579554
162Tracheomalacia (HP:0002779)1.52107493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.41134413
2NTRK13.90796669
3MAP3K143.49278463
4LATS13.49207306
5ZAK2.82676373
6MAP3K32.75776301
7PBK2.73069417
8ERBB32.63118954
9EPHB22.59816148
10TRPM72.44895348
11FRK2.27143682
12LMTK22.15768640
13EPHA32.06138481
14TTN2.05365542
15STK31.93470519
16BMPR21.93438524
17STK38L1.91970896
18NUAK11.77428681
19TAOK21.64963885
20EPHA21.63045192
21CHUK1.62601337
22MKNK21.55881249
23FGFR31.54613085
24TAF11.53921727
25MST41.47658293
26ICK1.40073149
27MKNK11.35051469
28BCR1.34175291
29ERBB41.33848794
30NTRK21.29746090
31FER1.29550921
32RIPK11.27751376
33EPHA41.22199892
34BMX1.21745128
35CASK1.20540090
36STK101.20119352
37IKBKB1.19482201
38PNCK1.17171924
39PIK3CA1.16049581
40PDGFRA1.15448437
41ARAF1.15159231
42MAPK151.14515112
43JAK31.13614593
44MET1.12375129
45MAP3K21.12175791
46KSR11.10037603
47RPS6KA41.09068019
48PTK61.08794173
49PKN21.08653857
50TESK11.08478429
51TGFBR21.08323032
52CDK61.04878982
53LATS21.01555071
54TNIK1.00595091
55STK391.00030636
56YES10.98739296
57EPHB10.98561421
58TBK10.98527621
59STK240.97657747
60NLK0.97308369
61FLT30.96111210
62ROCK20.93925057
63PAK40.92016367
64DMPK0.91987002
65MAP3K100.91395414
66SIK10.88156180
67TYK20.84831278
68MST1R0.84790557
69ERBB20.84646407
70MYLK0.84428932
71KSR20.83007141
72MTOR0.82999211
73TYRO30.82653205
74PTK20.81290652
75LRRK20.81174034
76MOS0.80991055
77TIE10.80496022
78PDGFRB0.80258320
79PIM10.80222957
80GRK10.76475869
81MARK10.76459786
82ROCK10.74975444
83IKBKE0.74272867
84MAP3K130.74070955
85MAP2K30.73574799
86CAMK1G0.72943223
87MAP3K90.71408641
88NEK60.71216221
89SIK30.69858192
90BRD40.68693835
91PLK20.67759928
92IRAK30.65821499
93PAK20.64285320
94EEF2K0.59336072
95MAPKAPK20.57764151
96RET0.55894830
97ABL10.55863478
98TRIB30.55359382
99STK40.55331045
100BMPR1B0.54563083
101PAK30.54184212
102PTK2B0.54008214
103MAPKAPK30.53712918
104FGFR10.53659094
105CDK120.52791617
106FGFR40.51612934
107MAP3K60.51573957
108LIMK10.51067551
109WNK10.50494170
110ABL20.50430556
111CLK10.49867304
112INSR0.49278533
113DYRK1B0.47541041
114MAPK70.47320420
115CAMK1D0.47276190
116OBSCN0.46780156
117EIF2AK20.46485263
118NEK90.46296161
119SGK20.46228360
120RPS6KA20.45090472
121MARK30.44991292
122IGF1R0.44341985
123MAP2K10.44255182
124FGFR20.43516648
125JAK10.42423603
126CSNK1A1L0.41638092
127GSK3A0.40748368
128CDK80.40711415
129CDK90.38346333
130IRAK40.38114408
131MAP2K70.37423621
132PIM20.36976445
133CDC42BPA0.36035611
134RPS6KB20.35298433
135MAP3K80.35231887
136PRKCE0.35124391
137IRAK10.34374124
138PRKD10.32393205
139STK380.31364507
140SRC0.31235239
141PRKG20.30499822
142CSNK1G20.30244777
143TGFBR10.29812850
144PRPF4B0.29556679
145RAF10.29525424
146MAP3K50.29490337
147IRAK20.28050166
148CSNK1G10.26090636
149RPS6KB10.24650814

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.55855166
2Adherens junction_Homo sapiens_hsa045202.17482890
3Basal cell carcinoma_Homo sapiens_hsa052172.15731286
4TGF-beta signaling pathway_Homo sapiens_hsa043502.09478401
5Hippo signaling pathway_Homo sapiens_hsa043902.06483853
6Small cell lung cancer_Homo sapiens_hsa052222.06076987
7Malaria_Homo sapiens_hsa051441.94336833
8Focal adhesion_Homo sapiens_hsa045101.88998495
9Proteoglycans in cancer_Homo sapiens_hsa052051.88035143
10Leishmaniasis_Homo sapiens_hsa051401.87674279
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.76785312
12Phototransduction_Homo sapiens_hsa047441.76703579
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71551225
14* TNF signaling pathway_Homo sapiens_hsa046681.71516536
15MicroRNAs in cancer_Homo sapiens_hsa052061.70043462
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65983984
17Graft-versus-host disease_Homo sapiens_hsa053321.63965824
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60262293
19Toxoplasmosis_Homo sapiens_hsa051451.57823779
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55732261
21Amoebiasis_Homo sapiens_hsa051461.52212178
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49096680
23Steroid biosynthesis_Homo sapiens_hsa001001.46768593
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.46374513
25Viral myocarditis_Homo sapiens_hsa054161.44530681
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43128828
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.41457022
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39637087
29Chronic myeloid leukemia_Homo sapiens_hsa052201.33939046
30Legionellosis_Homo sapiens_hsa051341.32006477
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29002969
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.27372568
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26888598
34Melanoma_Homo sapiens_hsa052181.26253341
35Allograft rejection_Homo sapiens_hsa053301.25912137
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24629816
37* Notch signaling pathway_Homo sapiens_hsa043301.24470219
38ErbB signaling pathway_Homo sapiens_hsa040121.21859644
39Rheumatoid arthritis_Homo sapiens_hsa053231.21453985
40Prostate cancer_Homo sapiens_hsa052151.20124632
41Pathways in cancer_Homo sapiens_hsa052001.19737263
42Dilated cardiomyopathy_Homo sapiens_hsa054141.19600743
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18454109
44Salmonella infection_Homo sapiens_hsa051321.16628422
45Bladder cancer_Homo sapiens_hsa052191.16208843
46Dorso-ventral axis formation_Homo sapiens_hsa043201.16112508
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15462642
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14847858
49Osteoclast differentiation_Homo sapiens_hsa043801.11446161
50p53 signaling pathway_Homo sapiens_hsa041151.11025904
51Shigellosis_Homo sapiens_hsa051311.10411787
52Protein digestion and absorption_Homo sapiens_hsa049741.10221250
53Hedgehog signaling pathway_Homo sapiens_hsa043401.08701979
54HTLV-I infection_Homo sapiens_hsa051661.07749038
55Apoptosis_Homo sapiens_hsa042101.05912331
56Influenza A_Homo sapiens_hsa051641.05563108
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05387538
58Tight junction_Homo sapiens_hsa045301.05013162
59Gap junction_Homo sapiens_hsa045401.03787022
60Pertussis_Homo sapiens_hsa051330.98319615
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97904593
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96499025
63Retinol metabolism_Homo sapiens_hsa008300.94842373
64Wnt signaling pathway_Homo sapiens_hsa043100.91861913
65African trypanosomiasis_Homo sapiens_hsa051430.91861323
66Pancreatic cancer_Homo sapiens_hsa052120.90649946
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.87706637
68Measles_Homo sapiens_hsa051620.87241321
69Endometrial cancer_Homo sapiens_hsa052130.86663912
70Thyroid cancer_Homo sapiens_hsa052160.85773955
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84723163
72Staphylococcus aureus infection_Homo sapiens_hsa051500.84040415
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83637562
74Tuberculosis_Homo sapiens_hsa051520.83618478
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82829375
76Herpes simplex infection_Homo sapiens_hsa051680.82111064
77Hepatitis B_Homo sapiens_hsa051610.81577694
78Rap1 signaling pathway_Homo sapiens_hsa040150.81534064
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81445382
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80744215
81Mineral absorption_Homo sapiens_hsa049780.78081931
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77875061
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.77802069
84Estrogen signaling pathway_Homo sapiens_hsa049150.77664090
85Phagosome_Homo sapiens_hsa041450.77093318
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76849099
87Thyroid hormone synthesis_Homo sapiens_hsa049180.76845353
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.75479653
89FoxO signaling pathway_Homo sapiens_hsa040680.74763622
90Complement and coagulation cascades_Homo sapiens_hsa046100.73122877
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72738663
92Prolactin signaling pathway_Homo sapiens_hsa049170.70620086
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69840567
94Choline metabolism in cancer_Homo sapiens_hsa052310.68225332
95Axon guidance_Homo sapiens_hsa043600.68081829
96Autoimmune thyroid disease_Homo sapiens_hsa053200.67983681
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67096235
98Hematopoietic cell lineage_Homo sapiens_hsa046400.66775810
99Chemokine signaling pathway_Homo sapiens_hsa040620.63822811
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63535804
101Melanogenesis_Homo sapiens_hsa049160.62165573
102Hepatitis C_Homo sapiens_hsa051600.60576210
103Lysine degradation_Homo sapiens_hsa003100.60027188
104Chemical carcinogenesis_Homo sapiens_hsa052040.59543583
105Arginine and proline metabolism_Homo sapiens_hsa003300.58782116
106Sphingolipid metabolism_Homo sapiens_hsa006000.58544758
107Circadian rhythm_Homo sapiens_hsa047100.58530741
108HIF-1 signaling pathway_Homo sapiens_hsa040660.58186933
109Renal cell carcinoma_Homo sapiens_hsa052110.57438458
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57240092
111Prion diseases_Homo sapiens_hsa050200.57052454
112Histidine metabolism_Homo sapiens_hsa003400.56671715
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56646972
114PPAR signaling pathway_Homo sapiens_hsa033200.55076027
115Insulin signaling pathway_Homo sapiens_hsa049100.54931344
116Acute myeloid leukemia_Homo sapiens_hsa052210.54395973
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.53508300
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53265372
119Inositol phosphate metabolism_Homo sapiens_hsa005620.52767482
120Ras signaling pathway_Homo sapiens_hsa040140.52632421
121Glycerolipid metabolism_Homo sapiens_hsa005610.52360809
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52244235
123Long-term depression_Homo sapiens_hsa047300.52131278
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52048899
125MAPK signaling pathway_Homo sapiens_hsa040100.51442576
126GnRH signaling pathway_Homo sapiens_hsa049120.51062315
127Bile secretion_Homo sapiens_hsa049760.51004130
128Renin secretion_Homo sapiens_hsa049240.50703932
129AMPK signaling pathway_Homo sapiens_hsa041520.50362312
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.50271886
131Platelet activation_Homo sapiens_hsa046110.49301981
132Colorectal cancer_Homo sapiens_hsa052100.49042991
133Ovarian steroidogenesis_Homo sapiens_hsa049130.47510013
134Glioma_Homo sapiens_hsa052140.47049991
135ABC transporters_Homo sapiens_hsa020100.46306215
136VEGF signaling pathway_Homo sapiens_hsa043700.45697365
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43160827
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36737735
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36355229
140Fatty acid biosynthesis_Homo sapiens_hsa000610.33902601
141Galactose metabolism_Homo sapiens_hsa000520.33201004
142Nitrogen metabolism_Homo sapiens_hsa009100.31042156
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30810201
144N-Glycan biosynthesis_Homo sapiens_hsa005100.29117076
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28150275
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26398850
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26332036

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