JAG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.62489986
2desmosome organization (GO:0002934)6.36871090
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.39415094
4plasma membrane repair (GO:0001778)4.47092602
5cell-substrate junction assembly (GO:0007044)4.23225786
6lymph vessel development (GO:0001945)4.08038719
7cytoskeletal anchoring at plasma membrane (GO:0007016)3.87760069
8ventricular cardiac muscle cell action potential (GO:0086005)3.83520003
9cell communication involved in cardiac conduction (GO:0086065)3.81583713
10molting cycle (GO:0042303)3.73849897
11hair cycle (GO:0042633)3.73849897
12regulation of hippo signaling (GO:0035330)3.68085914
13activation of Rac GTPase activity (GO:0032863)3.49467831
14regulation of water loss via skin (GO:0033561)3.39274281
15epithelial cell differentiation involved in prostate gland development (GO:0060742)3.38993682
16vascular endothelial growth factor signaling pathway (GO:0038084)3.36687554
17sarcomere organization (GO:0045214)3.32982586
18keratinocyte proliferation (GO:0043616)3.32033845
19regulation of cardioblast differentiation (GO:0051890)3.30124990
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.29994319
21negative regulation of potassium ion transmembrane transport (GO:1901380)3.29888920
22cardiac myofibril assembly (GO:0055003)3.28822299
23keratinization (GO:0031424)3.27451610
24layer formation in cerebral cortex (GO:0021819)3.24878220
25peptidyl-tyrosine autophosphorylation (GO:0038083)3.24443766
26endothelium development (GO:0003158)3.24370183
27establishment of skin barrier (GO:0061436)3.23032619
28endothelial cell chemotaxis (GO:0035767)3.19645358
29collecting duct development (GO:0072044)3.19521647
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.17805852
31negative regulation of cell fate specification (GO:0009996)3.14713304
32epithelial cell-cell adhesion (GO:0090136)3.11653440
33cell migration in hindbrain (GO:0021535)3.10437943
34regulation of secondary heart field cardioblast proliferation (GO:0003266)3.08308730
35regulation of cardioblast proliferation (GO:0003264)3.08308730
36regulation of heart rate by cardiac conduction (GO:0086091)3.03085969
37COPI coating of Golgi vesicle (GO:0048205)3.00809620
38Golgi transport vesicle coating (GO:0048200)3.00809620
39lymphangiogenesis (GO:0001946)3.00067351
40planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99720878
41surfactant homeostasis (GO:0043129)2.98974112
42insulin-like growth factor receptor signaling pathway (GO:0048009)2.97626001
43gap junction assembly (GO:0016264)2.93991106
44regulation of translational fidelity (GO:0006450)2.93895701
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93200274
46cardiac conduction (GO:0061337)2.90578897
47protein localization to endosome (GO:0036010)2.90495618
48cardiac muscle cell action potential involved in contraction (GO:0086002)2.89782180
49ectoderm development (GO:0007398)2.87183183
50maternal placenta development (GO:0001893)2.86667978
51negative regulation of keratinocyte proliferation (GO:0010839)2.86280464
52basement membrane organization (GO:0071711)2.82488685
53polarized epithelial cell differentiation (GO:0030859)2.81688022
54regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81295435
55regulation of clathrin-mediated endocytosis (GO:2000369)2.80889093
56cardiac muscle cell action potential (GO:0086001)2.78749735
57cell communication by electrical coupling (GO:0010644)2.77915210
58myofibril assembly (GO:0030239)2.76347725
59intermediate filament organization (GO:0045109)2.75231737
60regulation of transforming growth factor beta2 production (GO:0032909)2.74367522
61adherens junction assembly (GO:0034333)2.73489189
62cardiac muscle contraction (GO:0060048)2.73385167
63retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73208297
64regulation of hair follicle development (GO:0051797)2.72855640
65positive regulation of epidermis development (GO:0045684)2.72616477
66negative regulation of chondrocyte differentiation (GO:0032331)2.71936661
67positive regulation of epidermal cell differentiation (GO:0045606)2.71558961
68atrioventricular valve morphogenesis (GO:0003181)2.70276528
69embryonic heart tube development (GO:0035050)2.70132128
70sodium ion export (GO:0071436)2.69839990
71proline biosynthetic process (GO:0006561)2.68466385
72regulation of early endosome to late endosome transport (GO:2000641)2.68421207
73positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.66506513
74mitotic G1 DNA damage checkpoint (GO:0031571)2.66277512
75branching involved in salivary gland morphogenesis (GO:0060445)2.66145899
76skin development (GO:0043588)2.65042516
77endothelial cell differentiation (GO:0045446)2.64460972
78virion attachment to host cell (GO:0019062)2.63012394
79adhesion of symbiont to host cell (GO:0044650)2.63012394
80cell junction assembly (GO:0034329)2.62538482
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62462551
82establishment of apical/basal cell polarity (GO:0035089)2.62117435
83synaptic vesicle maturation (GO:0016188)2.61819426
84adherens junction organization (GO:0034332)2.61453089
85protein retention in ER lumen (GO:0006621)2.61067991
86renal system development (GO:0072001)2.60401368
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.60322365
88negative regulation of fatty acid transport (GO:2000192)2.59278794
89regulation of glucose import in response to insulin stimulus (GO:2001273)2.59088298
90regulation of p38MAPK cascade (GO:1900744)2.58610422
91positive regulation of synapse maturation (GO:0090129)2.58591274
92coronary vasculature morphogenesis (GO:0060977)2.58164761
93muscle filament sliding (GO:0030049)2.58062203
94actin-myosin filament sliding (GO:0033275)2.58062203
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57343683
96multicellular organismal water homeostasis (GO:0050891)2.57300765
97focal adhesion assembly (GO:0048041)2.57192771
98cell-substrate adherens junction assembly (GO:0007045)2.57192771
99chemical homeostasis within a tissue (GO:0048875)2.57162275
100regulation of synapse maturation (GO:0090128)2.55813114
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55134581
102Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54659811
103negative regulation of Ras GTPase activity (GO:0034261)2.54588957
104negative regulation of catenin import into nucleus (GO:0035414)2.52732478
105keratinocyte differentiation (GO:0030216)2.51993889
106cell-cell junction maintenance (GO:0045217)2.51788374
107regulation of fatty acid beta-oxidation (GO:0031998)2.51726435
108positive regulation of keratinocyte differentiation (GO:0045618)2.50708422
109epidermis development (GO:0008544)2.50338881
110endothelial cell morphogenesis (GO:0001886)2.49791019
111regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.48512469
112asymmetric protein localization (GO:0008105)2.48214712
113establishment of monopolar cell polarity (GO:0061162)2.47844961
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.47844961
115neural tube development (GO:0021915)2.45661770
116* apoptotic process involved in morphogenesis (GO:0060561)2.45217149
117regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45082054
118negative regulation of cell size (GO:0045792)2.44930896
119cardiac muscle cell development (GO:0055013)2.44823539
120regulation of receptor binding (GO:1900120)2.44230909
121regulation of axon extension involved in axon guidance (GO:0048841)2.44025046
122cell junction organization (GO:0034330)2.43904646
123positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.43271134
124heart trabecula formation (GO:0060347)2.42899052
125negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.42400854
126regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.42108649
127positive regulation of hair follicle development (GO:0051798)2.41783195
128positive regulation of hair cycle (GO:0042635)2.41783195
129cardiac cell development (GO:0055006)2.41436689
130actomyosin structure organization (GO:0031032)2.41007510
131establishment of planar polarity (GO:0001736)2.40957668
132establishment of tissue polarity (GO:0007164)2.40957668
133regulation of establishment of planar polarity (GO:0090175)2.40160316
134activation of protein kinase A activity (GO:0034199)2.39350648
135branching involved in mammary gland duct morphogenesis (GO:0060444)2.38920409
136cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.38494629
137endothelial tube morphogenesis (GO:0061154)2.38389476
138morphogenesis of an endothelium (GO:0003159)2.38389476
139establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38255374
140apical protein localization (GO:0045176)2.38015406
141protein localization to microtubule (GO:0035372)2.37663182
142renal filtration (GO:0097205)2.37254853
143regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36772988
144cardiac muscle cell proliferation (GO:0060038)2.36366682
145G1 DNA damage checkpoint (GO:0044783)2.34588614
146oocyte development (GO:0048599)2.33620676
147protein targeting to plasma membrane (GO:0072661)2.33161478
148regulation of glomerular filtration (GO:0003093)2.32529421
149semaphorin-plexin signaling pathway (GO:0071526)2.31978864
150positive regulation of protein kinase C signaling (GO:0090037)2.31755073
151cell junction maintenance (GO:0034331)2.30803491
152growth hormone secretion (GO:0030252)2.30521078
153regulation of skeletal muscle contraction (GO:0014819)2.29340487
154peptide cross-linking (GO:0018149)2.29047451
155cell migration involved in sprouting angiogenesis (GO:0002042)2.28614189
156axon extension involved in axon guidance (GO:0048846)2.27739359
157neuron projection extension involved in neuron projection guidance (GO:1902284)2.27739359
158negative regulation of potassium ion transport (GO:0043267)2.27193317
159ephrin receptor signaling pathway (GO:0048013)2.27023280
160regulation of membrane repolarization (GO:0060306)2.26771807
161establishment of nucleus localization (GO:0040023)2.26383113
162non-canonical Wnt signaling pathway (GO:0035567)2.25796195
163dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.24367649
164hippo signaling (GO:0035329)2.24204636
165stress fiber assembly (GO:0043149)2.24093139
166glial cell proliferation (GO:0014009)2.23774821
167regulation of synapse structural plasticity (GO:0051823)2.23592121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.18076370
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.67748441
3ZNF263_19887448_ChIP-Seq_K562_Human3.32055175
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.07786434
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30492896
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27199020
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.25425855
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19870420
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.13220354
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02661698
11* KDM2B_26808549_Chip-Seq_K562_Human2.00915197
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97002597
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95942518
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86216773
15ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84787792
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84569987
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.83413302
18SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78967511
19KDM2B_26808549_Chip-Seq_DND41_Human1.77033026
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.75540391
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73040277
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.69090401
23VDR_21846776_ChIP-Seq_THP-1_Human1.66785572
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66676998
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60234857
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60234857
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.59736929
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.57245816
29* LXR_22292898_ChIP-Seq_THP-1_Human1.57241423
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.57085097
31KDM2B_26808549_Chip-Seq_JURKAT_Human1.56711099
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52901539
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.49422759
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.49295498
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.48748829
36EZH2_22144423_ChIP-Seq_EOC_Human1.48166300
37DROSHA_22980978_ChIP-Seq_HELA_Human1.47620521
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44737080
39* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44174965
40* RNF2_27304074_Chip-Seq_ESCs_Mouse1.43389478
41* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43312250
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43183575
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.43118208
44MYC_22102868_ChIP-Seq_BL_Human1.43022732
45* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42191251
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40423917
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.40102272
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39575216
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39549132
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38478703
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38083706
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37125758
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37021231
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36467877
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36467877
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36467877
57* CTCF_27219007_Chip-Seq_Bcells_Human1.36199475
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35789099
59* EZH2_27294783_Chip-Seq_ESCs_Mouse1.35333436
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.35150212
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34406834
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.33788354
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32849546
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.32705245
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.29411179
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.29411179
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.28513607
68* TET1_21490601_ChIP-Seq_MESCs_Mouse1.27561468
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26614056
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26352381
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.26255469
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25228687
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.24280968
74HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24003733
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23435005
76* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23348954
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.22677363
78* CREB1_26743006_Chip-Seq_LNCaP_Human1.21993606
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.21829952
80* TP63_22573176_ChIP-Seq_HFKS_Human1.21185022
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20544446
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.19752562
83* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19656815
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19629949
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19026861
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18554581
87ATF3_27146783_Chip-Seq_COLON_Human1.16589237
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15610983
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15348435
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14900069
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14663775
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14550244
93AHR_22903824_ChIP-Seq_MCF-7_Human1.13804813
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13182247
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13128165
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12589591
97CLOCK_20551151_ChIP-Seq_293T_Human1.12418286
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11357418
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11352936
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11231295
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11199588
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11015591
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11015591
104SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10967476
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10721801
106* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10448151
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06307695
108FOXO3_23340844_ChIP-Seq_DLD1_Human1.06298831
109KLF5_25053715_ChIP-Seq_YYC3_Human1.06275176
110SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05274458
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04356422
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03993668
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03833964
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.02547163
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02014921
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00956284
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00822330
118SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00808680
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.98460858
120* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97725293
121PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.97049610
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96955173
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96891832
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96627811
125P68_20966046_ChIP-Seq_HELA_Human0.96260711
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.95409494
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95233564
128SMC4_20622854_ChIP-Seq_HELA_Human0.95170078
129TP53_22127205_ChIP-Seq_IMR90_Human0.94578404
130AR_21572438_ChIP-Seq_LNCaP_Human0.94282182
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94220286
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94139270
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93937421
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93852131
135* CHD1_26751641_Chip-Seq_LNCaP_Human0.93443684
136NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93036504
137* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92451027
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91396308
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90223047
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89921910
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89611540
142AR_21909140_ChIP-Seq_LNCAP_Human0.88848926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology3.41898538
2MP0010234_abnormal_vibrissa_follicle3.39447573
3MP0003705_abnormal_hypodermis_morpholog3.26198260
4MP0005409_darkened_coat_color3.25490211
5MP0002234_abnormal_pharynx_morphology3.12985356
6MP0002796_impaired_skin_barrier2.94152871
7MP0000566_synostosis2.87096027
8MP0000751_myopathy2.85537997
9MP0002254_reproductive_system_inflammat2.66757653
10MP0001849_ear_inflammation2.66618459
11MP0005275_abnormal_skin_tensile2.45928667
12MP0004084_abnormal_cardiac_muscle2.45250555
13MP0002837_dystrophic_cardiac_calcinosis2.18765470
14MP0003941_abnormal_skin_development2.14373246
15MP0000383_abnormal_hair_follicle2.12052124
16MP0002249_abnormal_larynx_morphology2.08836877
17MP0010030_abnormal_orbit_morphology2.03123932
18MP0010678_abnormal_skin_adnexa2.02149412
19MP0000762_abnormal_tongue_morphology1.98912400
20MP0000467_abnormal_esophagus_morphology1.94200668
21MP0001346_abnormal_lacrimal_gland1.94142401
22MP0003566_abnormal_cell_adhesion1.91320133
23MP0001879_abnormal_lymphatic_vessel1.88117728
24MP0004272_abnormal_basement_membrane1.87508634
25MP0003646_muscle_fatigue1.82978059
26MP0005623_abnormal_meninges_morphology1.82427287
27MP0005367_renal/urinary_system_phenotyp1.74747808
28MP0000516_abnormal_urinary_system1.74747808
29MP0003453_abnormal_keratinocyte_physiol1.73765728
30MP0002098_abnormal_vibrissa_morphology1.73498891
31MP0004036_abnormal_muscle_relaxation1.72467688
32MP0005501_abnormal_skin_physiology1.70585921
33MP0002060_abnormal_skin_morphology1.67014677
34MP0005451_abnormal_body_composition1.62489700
35MP0002877_abnormal_melanocyte_morpholog1.61960910
36MP0000537_abnormal_urethra_morphology1.61874839
37MP0002909_abnormal_adrenal_gland1.61312298
38MP0000733_abnormal_muscle_development1.59981706
39MP0003315_abnormal_perineum_morphology1.58362130
40MP0004858_abnormal_nervous_system1.58282141
41MP0004215_abnormal_myocardial_fiber1.56846801
42MP0005330_cardiomyopathy1.51672383
43MP0000750_abnormal_muscle_regeneration1.50957570
44MP0000647_abnormal_sebaceous_gland1.50819981
45MP0004859_abnormal_synaptic_plasticity1.50803696
46MP0004185_abnormal_adipocyte_glucose1.50242718
47MP0006138_congestive_heart_failure1.49532470
48MP0003283_abnormal_digestive_organ1.49455615
49MP0004087_abnormal_muscle_fiber1.48816864
50MP0004381_abnormal_hair_follicle1.43810292
51MP0004782_abnormal_surfactant_physiolog1.38519464
52MP0005076_abnormal_cell_differentiation1.36579105
53MP0004145_abnormal_muscle_electrophysio1.35546225
54MP0008961_abnormal_basal_metabolism1.35053196
55MP0008789_abnormal_olfactory_epithelium1.34439725
56* MP0001216_abnormal_epidermal_layer1.33562396
57MP0010771_integument_phenotype1.26610485
58MP0009053_abnormal_anal_canal1.24506758
59MP0010630_abnormal_cardiac_muscle1.22447768
60MP0002653_abnormal_ependyma_morphology1.19725522
61MP0000749_muscle_degeneration1.19686125
62MP0005670_abnormal_white_adipose1.19425924
63MP0000377_abnormal_hair_follicle1.18397075
64MP0002106_abnormal_muscle_physiology1.17332986
65MP0005167_abnormal_blood-brain_barrier1.17313933
66MP0000003_abnormal_adipose_tissue1.16734234
67MP0004233_abnormal_muscle_weight1.13959341
68MP0002972_abnormal_cardiac_muscle1.12772131
69MP0000759_abnormal_skeletal_muscle1.12696237
70MP0005620_abnormal_muscle_contractility1.11404570
71MP0000534_abnormal_ureter_morphology1.08899264
72MP0005499_abnormal_olfactory_system1.07816338
73MP0005394_taste/olfaction_phenotype1.07816338
74MP0004264_abnormal_extraembryonic_tissu1.07191825
75MP0000427_abnormal_hair_cycle1.04532710
76MP0004130_abnormal_muscle_cell1.04156833
77MP0005187_abnormal_penis_morphology1.01223282
78MP0005375_adipose_tissue_phenotype1.00455189
79MP0004484_altered_response_of1.00162732
80MP0009780_abnormal_chondrocyte_physiolo0.99970255
81MP0004270_analgesia0.99819539
82MP0009931_abnormal_skin_appearance0.97205353
83MP0003137_abnormal_impulse_conducting0.96969321
84MP0000678_abnormal_parathyroid_gland0.96812717
85MP0002269_muscular_atrophy0.96411258
86MP0005369_muscle_phenotype0.94807012
87MP0000747_muscle_weakness0.94706787
88MP0000767_abnormal_smooth_muscle0.94590162
89MP0003119_abnormal_digestive_system0.94106243
90MP0002108_abnormal_muscle_morphology0.93084905
91MP0005385_cardiovascular_system_phenoty0.92024716
92MP0001544_abnormal_cardiovascular_syste0.92024716
93MP0004085_abnormal_heartbeat0.91650822
94MP0003385_abnormal_body_wall0.90292468
95MP0005248_abnormal_Harderian_gland0.90208000
96MP0003828_pulmonary_edema0.89941089
97MP0008775_abnormal_heart_ventricle0.89809418
98MP0009379_abnormal_foot_pigmentation0.89117241
99MP0005666_abnormal_adipose_tissue0.86516598
100MP0003123_paternal_imprinting0.86459172
101MP0001299_abnormal_eye_distance/0.86456956
102MP0002697_abnormal_eye_size0.86393112
103* MP0003935_abnormal_craniofacial_develop0.84926059
104* MP0003755_abnormal_palate_morphology0.80595831
105MP0001348_abnormal_lacrimal_gland0.79649458
106MP0002127_abnormal_cardiovascular_syste0.78853849
107MP0001784_abnormal_fluid_regulation0.78577194
108MP0000462_abnormal_digestive_system0.78519684
109MP0009278_abnormal_bone_marrow0.78363877
110MP0000428_abnormal_craniofacial_morphol0.78061626
111MP0002233_abnormal_nose_morphology0.77870644
112MP0010352_gastrointestinal_tract_polyps0.76749272
113MP0010368_abnormal_lymphatic_system0.76602365
114MP0001851_eye_inflammation0.75802247
115MP0000627_abnormal_mammary_gland0.75283779
116MP0001730_embryonic_growth_arrest0.74950709
117MP0002925_abnormal_cardiovascular_devel0.74730652
118MP0008260_abnormal_autophagy0.74701436
119MP0000013_abnormal_adipose_tissue0.74233641
120MP0005257_abnormal_intraocular_pressure0.74185958
121MP0003091_abnormal_cell_migration0.73972937
122MP0003045_fibrosis0.73545548
123MP0002089_abnormal_postnatal_growth/wei0.73185467
124MP0005023_abnormal_wound_healing0.72347269
125MP0001188_hyperpigmentation0.69372528
126MP0005058_abnormal_lysosome_morphology0.67807732
127MP0003984_embryonic_growth_retardation0.66943293
128MP0002086_abnormal_extraembryonic_tissu0.66180207
129MP0002896_abnormal_bone_mineralization0.64275720
130MP0001661_extended_life_span0.62914051
131MP0002088_abnormal_embryonic_growth/wei0.61003216
132MP0005380_embryogenesis_phenotype0.60713377
133MP0001672_abnormal_embryogenesis/_devel0.60713377
134MP0002822_catalepsy0.60684975
135MP0001340_abnormal_eyelid_morphology0.59578857
136MP0004197_abnormal_fetal_growth/weight/0.58210085
137MP0002932_abnormal_joint_morphology0.57295006
138* MP0002116_abnormal_craniofacial_bone0.55319949
139* MP0002111_abnormal_tail_morphology0.54615226
140MP0001614_abnormal_blood_vessel0.53769289

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)6.52884858
2Right ventricular cardiomyopathy (HP:0011663)4.85948083
3Fragile nails (HP:0001808)4.74640354
4Atrophic scars (HP:0001075)4.70818413
5Onycholysis (HP:0001806)3.98578085
6Pili torti (HP:0003777)3.86742043
7Plantar hyperkeratosis (HP:0007556)3.82787650
8Sudden death (HP:0001699)3.77478267
9Abnormality of nail color (HP:0100643)3.73323631
10Hypotrichosis (HP:0001006)3.66663118
11Hyporeflexia of lower limbs (HP:0002600)3.47578205
12Ventricular tachycardia (HP:0004756)3.45326351
13Increased connective tissue (HP:0009025)3.44703192
14Ventricular fibrillation (HP:0001663)3.23402461
15Woolly hair (HP:0002224)3.18037941
16Muscle fiber splitting (HP:0003555)3.14355644
17Fragile skin (HP:0001030)3.05686104
18Difficulty running (HP:0009046)3.04350074
19Broad face (HP:0000283)2.96932105
20Nail dystrophy (HP:0008404)2.89290912
21Exercise-induced myalgia (HP:0003738)2.85740813
22Difficulty climbing stairs (HP:0003551)2.74857242
23Hyperacusis (HP:0010780)2.69594865
24Type 1 muscle fiber predominance (HP:0003803)2.66391510
25Trismus (HP:0000211)2.64487602
26Esophageal atresia (HP:0002032)2.61851699
27Cerebral aneurysm (HP:0004944)2.57493350
28Scapular winging (HP:0003691)2.56307988
29Septate vagina (HP:0001153)2.55975946
30Exercise-induced muscle cramps (HP:0003710)2.53072849
31Palmoplantar hyperkeratosis (HP:0000972)2.46082385
32Ulnar bowing (HP:0003031)2.43145669
33Abnormality of the salivary glands (HP:0010286)2.40517125
34Increased variability in muscle fiber diameter (HP:0003557)2.39988890
35Ankyloglossia (HP:0010296)2.38434031
36Thick nail (HP:0001805)2.35712338
37Neoplasm of the heart (HP:0100544)2.34951627
38Abnormality of the neuromuscular junction (HP:0003398)2.33849129
39Fatigable weakness (HP:0003473)2.33849129
40Shallow orbits (HP:0000586)2.32050478
41Palmar hyperkeratosis (HP:0010765)2.31450335
42Bronchomalacia (HP:0002780)2.29603482
43Insomnia (HP:0100785)2.29538848
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.28325266
45Myopathic facies (HP:0002058)2.26831047
46Bundle branch block (HP:0011710)2.22835477
47Dysmetric saccades (HP:0000641)2.21796425
48Calf muscle hypertrophy (HP:0008981)2.19355984
49Abnormality of the distal phalanges of the toes (HP:0010182)2.19195310
50Abnormality of the calf musculature (HP:0001430)2.18128234
51Abnormality of skeletal muscle fiber size (HP:0012084)2.17990550
52Oligodontia (HP:0000677)2.17964676
53Abnormal blistering of the skin (HP:0008066)2.17620671
54Syncope (HP:0001279)2.16777655
55Thin bony cortex (HP:0002753)2.16448383
56Ventricular arrhythmia (HP:0004308)2.16146263
57Germ cell neoplasia (HP:0100728)2.15315896
58Mildly elevated creatine phosphokinase (HP:0008180)2.13899010
59Advanced eruption of teeth (HP:0006288)2.12898318
60Skin pits (HP:0100276)2.12648789
61Popliteal pterygium (HP:0009756)2.12182452
62Myotonia (HP:0002486)2.10380742
63Curly hair (HP:0002212)2.10286006
64Flat acetabular roof (HP:0003180)2.09878701
65Distal upper limb amyotrophy (HP:0007149)2.09565098
66Upper limb amyotrophy (HP:0009129)2.09565098
67Elfin facies (HP:0004428)2.08893049
68Abnormal hair laboratory examination (HP:0003328)2.08211213
69Diaphragmatic weakness (HP:0009113)2.08085060
70Aplasia cutis congenita (HP:0001057)2.06891103
71Alacrima (HP:0000522)2.06816339
72Ridged nail (HP:0001807)2.06007008
73Absent eyelashes (HP:0000561)2.04270311
74Overriding aorta (HP:0002623)2.03122235
75Short nail (HP:0001799)2.01717074
76Hamartoma of the eye (HP:0010568)2.01379227
77Atrial fibrillation (HP:0005110)2.00598211
78Acanthosis nigricans (HP:0000956)1.99847780
79Distal lower limb muscle weakness (HP:0009053)1.99239567
80Pterygium (HP:0001059)1.98647123
81Muscle hypertrophy of the lower extremities (HP:0008968)1.98360707
82Bulbar palsy (HP:0001283)1.97467912
83Primary atrial arrhythmia (HP:0001692)1.96033376
84Renovascular hypertension (HP:0100817)1.95464872
85EMG: myopathic abnormalities (HP:0003458)1.94544015
86Stridor (HP:0010307)1.94541487
87Achilles tendon contracture (HP:0001771)1.93660823
88Round ear (HP:0100830)1.93142524
89Neonatal death (HP:0003811)1.92398004
90Lip pit (HP:0100267)1.91589454
91Supraventricular arrhythmia (HP:0005115)1.91139414
92Hypoplasia of dental enamel (HP:0006297)1.89931720
93EMG: neuropathic changes (HP:0003445)1.89849287
94Laryngomalacia (HP:0001601)1.86622321
95Natal tooth (HP:0000695)1.85574965
96Aplasia involving bones of the extremities (HP:0009825)1.84658419
97Aplasia involving bones of the upper limbs (HP:0009823)1.84658419
98Aplasia of the phalanges of the hand (HP:0009802)1.84658419
99Supraventricular tachycardia (HP:0004755)1.83788552
100Abnormality of the left ventricular outflow tract (HP:0011103)1.82398258
101Subaortic stenosis (HP:0001682)1.82398258
102Bladder diverticulum (HP:0000015)1.81773556
103Short 4th metacarpal (HP:0010044)1.81612443
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81612443
105Skull defect (HP:0001362)1.80519831
106Unilateral renal agenesis (HP:0000122)1.80425355
107Renal duplication (HP:0000075)1.78139960
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.76299232
109Sparse scalp hair (HP:0002209)1.75075574
110Selective tooth agenesis (HP:0001592)1.74770032
111Periauricular skin pits (HP:0100277)1.73119290
112Preauricular pit (HP:0004467)1.73119290
113Abnormality of the lower motor neuron (HP:0002366)1.72824908
114Down-sloping shoulders (HP:0200021)1.72671133
115Flat cornea (HP:0007720)1.72431942
116Abnormality of the gastric mucosa (HP:0004295)1.72089963
117Distal lower limb amyotrophy (HP:0008944)1.72079223
118Anonychia (HP:0001798)1.72013739
119Abnormality of oral frenula (HP:0000190)1.72004903
120Easy fatigability (HP:0003388)1.71555779
121Spinal rigidity (HP:0003306)1.70835071
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70081135
123Absent hand (HP:0004050)1.69923613
124Long palpebral fissure (HP:0000637)1.69566422
125Lymphangioma (HP:0100764)1.69058754
126Conjunctival hamartoma (HP:0100780)1.68203357
127Cervical subluxation (HP:0003308)1.68095801
128Ureteral duplication (HP:0000073)1.67913885
129Vertebral arch anomaly (HP:0008438)1.67379498
130Spinal cord compression (HP:0002176)1.66856801
131Lower limb amyotrophy (HP:0007210)1.66597824
132Abnormal atrioventricular conduction (HP:0005150)1.65229502
133Palmoplantar keratoderma (HP:0000982)1.65123224
134Axonal loss (HP:0003447)1.63878562
135Limb-girdle muscle atrophy (HP:0003797)1.62592880
136Deviation of the thumb (HP:0009603)1.62382692
137Obstructive sleep apnea (HP:0002870)1.62330532
138Alopecia of scalp (HP:0002293)1.61983036
139Pointed chin (HP:0000307)1.61812680
140Sparse eyelashes (HP:0000653)1.61722339
141Nasolacrimal duct obstruction (HP:0000579)1.60053788
142Breast hypoplasia (HP:0003187)1.59910951
143Abnormality of the Achilles tendon (HP:0005109)1.59218558
144Cerebral inclusion bodies (HP:0100314)1.59069912
145Premature rupture of membranes (HP:0001788)1.57943321
146Bowel incontinence (HP:0002607)1.57338050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.79891233
2MST1R3.67844437
3PKN23.48146375
4SMG13.03387795
5TTN3.02864001
6RIPK13.01841189
7EEF2K2.72304234
8MAP3K92.39906778
9TIE12.20403249
10LATS12.19816275
11FER2.15698228
12PRKD32.15476646
13ARAF2.10165902
14KDR2.06951151
15MAPKAPK32.01450060
16DMPK1.98043722
17LATS21.95072645
18PHKG11.93731171
19PHKG21.93731171
20EPHA21.92581081
21IRAK31.84827670
22ICK1.79902949
23LMTK21.76634884
24TAOK11.74587841
25MAPK151.70149900
26KSR21.63719890
27MAP3K21.51197279
28NME21.50417371
29PDGFRA1.49609473
30EPHB21.43868987
31CAMK1D1.41153403
32RPS6KB21.40266688
33PTK61.38147750
34MAP3K101.37684307
35PAK61.37248505
36ALK1.33290347
37RET1.29772000
38BMX1.27874968
39NEK11.21791328
40TYRO31.21183252
41MAP3K31.15966326
42STK381.10814669
43MAP3K11.09455282
44NTRK11.06059304
45PTK21.03689933
46BRAF1.03431751
47CDK121.02178799
48NME11.00946791
49CDC42BPA0.98660530
50NTRK20.97709715
51PIM20.97344350
52MAP3K70.96866571
53MTOR0.95415734
54TGFBR20.93284165
55PRKD10.91076700
56PRPF4B0.90984048
57OBSCN0.90487453
58MARK10.87177768
59NTRK30.86789472
60MUSK0.85145760
61DAPK20.84877331
62MAP3K130.84782491
63MINK10.82504988
64MAP3K60.82379848
65SIK10.81736071
66FGFR20.79855910
67MAP3K40.77864964
68TNK20.77664158
69MAP2K40.77650061
70STK110.76131669
71MAP2K10.71483496
72TESK10.71267948
73CAMKK10.70691571
74FGFR10.70665524
75RPS6KA20.69248889
76MARK20.68902924
77EPHB10.68509456
78PAK30.68199837
79ILK0.66642848
80PAK20.66364193
81PDK40.65266430
82PDK30.65266430
83PDPK10.65020678
84PRKD20.64167142
85ERN10.62661149
86MAP2K20.62383532
87LRRK20.61760568
88MAPK120.60829412
89ROCK10.59246039
90AKT20.59017546
91PAK40.57613046
92RPS6KA10.55475698
93IRAK20.53812123
94MAP2K60.53032903
95MAP2K30.52737105
96TRPM70.52377689
97PRKCH0.51082686
98DDR20.50814961
99RPS6KL10.50747335
100RPS6KC10.50747335
101FGFR40.50350211
102SIK20.49956931
103TSSK60.49677481
104MAP3K110.48714642
105TGFBR10.48489603
106ERBB20.48120110
107PTK2B0.47449260
108MAP3K80.47165097
109KSR10.44865256
110PRKAA20.44818788
111PDGFRB0.43970654
112SCYL20.43435015
113PRKCI0.43243020
114CDK50.41205275
115MET0.40875003
116CAMK1G0.40783455
117PRKG20.40331900
118DYRK1B0.40165741
119CDK70.38829610
120NEK60.37786964
121AURKA0.37507260
122PRKAA10.37391840
123STK38L0.37348825
124RAF10.36582189
125CAMK2G0.36010090
126CAMK10.35093023
127RPS6KA60.33535497
128CAMK40.33127570
129ROCK20.33028239
130MAPK80.32852595
131PDK20.32447444
132RPS6KB10.29892935
133MAPK110.28962849
134CDK80.27829664
135CDK90.25903028
136SGK30.25720107
137MAPKAPK50.25631651
138MAPK100.25429660
139CAMK2B0.24628958

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.33325427
2Dilated cardiomyopathy_Homo sapiens_hsa054142.16783962
3Basal cell carcinoma_Homo sapiens_hsa052171.88692245
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86987748
5Dorso-ventral axis formation_Homo sapiens_hsa043201.72116927
6ECM-receptor interaction_Homo sapiens_hsa045121.68269429
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66171092
8Hedgehog signaling pathway_Homo sapiens_hsa043401.65418040
9Estrogen signaling pathway_Homo sapiens_hsa049151.57082909
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56592535
11Focal adhesion_Homo sapiens_hsa045101.54285457
12Hippo signaling pathway_Homo sapiens_hsa043901.51198935
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51173256
14GnRH signaling pathway_Homo sapiens_hsa049121.47419573
15Endometrial cancer_Homo sapiens_hsa052131.41087495
16VEGF signaling pathway_Homo sapiens_hsa043701.39970610
17Sulfur relay system_Homo sapiens_hsa041221.39097774
18Type II diabetes mellitus_Homo sapiens_hsa049301.38833251
19Phenylalanine metabolism_Homo sapiens_hsa003601.38690052
20Arginine biosynthesis_Homo sapiens_hsa002201.38292300
21Adherens junction_Homo sapiens_hsa045201.38125916
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37733882
23Axon guidance_Homo sapiens_hsa043601.37091826
24Glioma_Homo sapiens_hsa052141.36598510
25mTOR signaling pathway_Homo sapiens_hsa041501.35792937
26Melanogenesis_Homo sapiens_hsa049161.35365698
27Tight junction_Homo sapiens_hsa045301.35200601
28Oxytocin signaling pathway_Homo sapiens_hsa049211.34539466
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33579331
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32432085
31Gastric acid secretion_Homo sapiens_hsa049711.29952967
32Proteoglycans in cancer_Homo sapiens_hsa052051.28667352
33Fructose and mannose metabolism_Homo sapiens_hsa000511.28420833
34Renal cell carcinoma_Homo sapiens_hsa052111.27423713
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25713314
36Insulin secretion_Homo sapiens_hsa049111.25325171
37Olfactory transduction_Homo sapiens_hsa047401.24444120
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.23810999
39Amoebiasis_Homo sapiens_hsa051461.23361475
40Long-term potentiation_Homo sapiens_hsa047201.23244840
41* Notch signaling pathway_Homo sapiens_hsa043301.22922335
42Prion diseases_Homo sapiens_hsa050201.21225155
43Circadian entrainment_Homo sapiens_hsa047131.19887300
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.18506616
45Small cell lung cancer_Homo sapiens_hsa052221.18164355
46Gap junction_Homo sapiens_hsa045401.16407469
47Pentose phosphate pathway_Homo sapiens_hsa000301.15230136
48Chronic myeloid leukemia_Homo sapiens_hsa052201.14899582
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.14895008
50Bladder cancer_Homo sapiens_hsa052191.14425336
51Insulin signaling pathway_Homo sapiens_hsa049101.13465544
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12399216
53Biosynthesis of amino acids_Homo sapiens_hsa012301.11982066
54Lysine degradation_Homo sapiens_hsa003101.11484243
55Insulin resistance_Homo sapiens_hsa049311.11098680
56Cholinergic synapse_Homo sapiens_hsa047251.10573739
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09475613
58Cardiac muscle contraction_Homo sapiens_hsa042601.08813645
59ErbB signaling pathway_Homo sapiens_hsa040121.08134038
60Salivary secretion_Homo sapiens_hsa049701.07593386
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06641339
62Non-small cell lung cancer_Homo sapiens_hsa052231.04427102
63Renin secretion_Homo sapiens_hsa049241.04277046
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01135283
65Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00994050
66Neurotrophin signaling pathway_Homo sapiens_hsa047221.00893634
67Rap1 signaling pathway_Homo sapiens_hsa040150.99864033
68Arginine and proline metabolism_Homo sapiens_hsa003300.98028909
69Vitamin B6 metabolism_Homo sapiens_hsa007500.97671403
70Fatty acid biosynthesis_Homo sapiens_hsa000610.96988952
71Thyroid cancer_Homo sapiens_hsa052160.95607241
72Wnt signaling pathway_Homo sapiens_hsa043100.94267818
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93683995
74cAMP signaling pathway_Homo sapiens_hsa040240.93491086
75Amphetamine addiction_Homo sapiens_hsa050310.93160334
76Dopaminergic synapse_Homo sapiens_hsa047280.92694260
77Synaptic vesicle cycle_Homo sapiens_hsa047210.92191274
78MicroRNAs in cancer_Homo sapiens_hsa052060.91341004
79Colorectal cancer_Homo sapiens_hsa052100.91151469
80Prolactin signaling pathway_Homo sapiens_hsa049170.89423738
81Pathways in cancer_Homo sapiens_hsa052000.88419033
82Glucagon signaling pathway_Homo sapiens_hsa049220.87397987
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87314428
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.86300962
85MAPK signaling pathway_Homo sapiens_hsa040100.85413011
86Cocaine addiction_Homo sapiens_hsa050300.84819333
87Calcium signaling pathway_Homo sapiens_hsa040200.84227476
88Galactose metabolism_Homo sapiens_hsa000520.84026962
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82794942
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.82460853
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82172317
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82056495
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80269995
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80075198
95Toxoplasmosis_Homo sapiens_hsa051450.79180733
96Inositol phosphate metabolism_Homo sapiens_hsa005620.78111782
97Protein digestion and absorption_Homo sapiens_hsa049740.77730300
98Acute myeloid leukemia_Homo sapiens_hsa052210.77264214
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76937970
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.76861723
101Glutamatergic synapse_Homo sapiens_hsa047240.76040459
102Ras signaling pathway_Homo sapiens_hsa040140.75589981
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75386156
104HIF-1 signaling pathway_Homo sapiens_hsa040660.75183263
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74850935
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.73967293
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73603839
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73395151
109Choline metabolism in cancer_Homo sapiens_hsa052310.72900850
110AMPK signaling pathway_Homo sapiens_hsa041520.72798517
111Long-term depression_Homo sapiens_hsa047300.71197435
112Melanoma_Homo sapiens_hsa052180.70811956
113Prostate cancer_Homo sapiens_hsa052150.70765421
114GABAergic synapse_Homo sapiens_hsa047270.70506911
115Oocyte meiosis_Homo sapiens_hsa041140.70277159
116Pancreatic cancer_Homo sapiens_hsa052120.70117503
117Taste transduction_Homo sapiens_hsa047420.70071120
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67817524
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67017248
120Viral myocarditis_Homo sapiens_hsa054160.65446985
121Platelet activation_Homo sapiens_hsa046110.65445100
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.65070706
123Carbon metabolism_Homo sapiens_hsa012000.63448476
124Endocytosis_Homo sapiens_hsa041440.62742680
125Other glycan degradation_Homo sapiens_hsa005110.60753670
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59050044
127Pyruvate metabolism_Homo sapiens_hsa006200.55575737
128Bile secretion_Homo sapiens_hsa049760.55258607
129Ovarian steroidogenesis_Homo sapiens_hsa049130.54906015

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