JAK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.44764117
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.44764117
3positive regulation of gamma-delta T cell activation (GO:0046645)6.69470798
4antigen processing and presentation of endogenous antigen (GO:0019883)6.61042747
5regulation of gamma-delta T cell differentiation (GO:0045586)5.70619721
6regulation of gamma-delta T cell activation (GO:0046643)5.19194968
7positive thymic T cell selection (GO:0045059)4.94574992
8negative T cell selection (GO:0043383)4.85644579
9negative thymic T cell selection (GO:0045060)4.83050861
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.73268661
11* response to interleukin-15 (GO:0070672)4.52571651
12thymic T cell selection (GO:0045061)4.41335264
13cellular response to interleukin-15 (GO:0071350)4.37197274
14positive regulation by symbiont of host defense response (GO:0052509)4.25927669
15modulation by symbiont of host defense response (GO:0052031)4.25927669
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.25927669
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.25927669
18positive regulation by organism of defense response of other organism involved in symbiotic interact4.25927669
19modulation by symbiont of host immune response (GO:0052553)4.25927669
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.20254759
21tolerance induction (GO:0002507)4.19661730
22positive regulation of B cell differentiation (GO:0045579)4.16152941
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.12742391
24positive T cell selection (GO:0043368)4.11950086
25T cell migration (GO:0072678)4.09502626
26negative regulation of erythrocyte differentiation (GO:0045647)4.08219098
27T cell selection (GO:0045058)4.07153241
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05516016
29negative regulation of cell killing (GO:0031342)4.05516016
30detection of bacterium (GO:0016045)4.04557413
31detection of other organism (GO:0098543)4.04385161
32negative regulation of T cell mediated immunity (GO:0002710)4.01309834
33antigen processing and presentation via MHC class Ib (GO:0002475)3.96717974
34regulation of B cell receptor signaling pathway (GO:0050855)3.96005040
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.93379958
36interferon-gamma production (GO:0032609)3.88467690
37regulation of B cell differentiation (GO:0045577)3.87125813
38neutrophil activation involved in immune response (GO:0002283)3.83548412
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.75581659
40regulation of interleukin-2 biosynthetic process (GO:0045076)3.64583016
41cellular extravasation (GO:0045123)3.58744158
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57381282
43* negative regulation of leukocyte mediated immunity (GO:0002704)3.56374079
44macrophage activation involved in immune response (GO:0002281)3.54200522
45B cell receptor signaling pathway (GO:0050853)3.50092550
46regulation of tolerance induction (GO:0002643)3.50005964
47leukocyte aggregation (GO:0070486)3.48382537
48regulation of T cell mediated cytotoxicity (GO:0001914)3.47683471
49T cell receptor signaling pathway (GO:0050852)3.44523922
50positive regulation of interleukin-2 production (GO:0032743)3.41318926
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39427626
52positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39395427
53NIK/NF-kappaB signaling (GO:0038061)3.39037219
54germinal center formation (GO:0002467)3.37973993
55interferon-gamma-mediated signaling pathway (GO:0060333)3.36511897
56antigen receptor-mediated signaling pathway (GO:0050851)3.32439328
57neutrophil activation (GO:0042119)3.32220711
58defense response to protozoan (GO:0042832)3.32010962
59positive regulation of histone deacetylation (GO:0031065)3.31969848
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.30842578
61regulation of type I interferon-mediated signaling pathway (GO:0060338)3.30267775
62regulation of response to interferon-gamma (GO:0060330)3.25365331
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25169563
64B cell mediated immunity (GO:0019724)3.23927142
65regulation of isotype switching to IgG isotypes (GO:0048302)3.23916408
66response to muramyl dipeptide (GO:0032495)3.23895154
67myeloid cell activation involved in immune response (GO:0002275)3.23891696
68regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.22406828
69detection of external biotic stimulus (GO:0098581)3.22287941
70T cell costimulation (GO:0031295)3.22105859
71* T cell homeostasis (GO:0043029)3.21054213
72* negative regulation of interleukin-12 production (GO:0032695)3.20804681
73negative regulation of innate immune response (GO:0045824)3.20682520
74ribosomal small subunit assembly (GO:0000028)3.20657454
75regulation of regulatory T cell differentiation (GO:0045589)3.19746187
76respiratory burst (GO:0045730)3.19709839
77mature B cell differentiation (GO:0002335)3.18688115
78negative regulation of phagocytosis (GO:0050765)3.18517619
79regulation of T cell tolerance induction (GO:0002664)3.16253119
80lymphocyte costimulation (GO:0031294)3.16129499
81response to peptidoglycan (GO:0032494)3.15837225
82regulation of interferon-beta biosynthetic process (GO:0045357)3.15694496
83leukocyte degranulation (GO:0043299)3.13671815
84positive regulation of isotype switching (GO:0045830)3.13046918
85lymph node development (GO:0048535)3.11695819
86regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.09273256
87positive regulation of antigen processing and presentation (GO:0002579)3.09115803
88* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.08938253
89viral transcription (GO:0019083)3.07936077
90dendritic cell chemotaxis (GO:0002407)3.07495138
91granulocyte activation (GO:0036230)3.06490330
92regulation of antigen processing and presentation (GO:0002577)3.06462163
93natural killer cell differentiation (GO:0001779)3.06088344
94positive regulation of natural killer cell differentiation (GO:0032825)3.05534686
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01312762
96positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.00902981
97response to host immune response (GO:0052572)3.00745434
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00745434
99regulation of alpha-beta T cell proliferation (GO:0046640)2.98908643
100dendritic cell migration (GO:0036336)2.95844055
101regulation of cell killing (GO:0031341)2.93765722
102regulation of interleukin-2 production (GO:0032663)2.93158507
103Peyers patch development (GO:0048541)2.91735530
104mucosal-associated lymphoid tissue development (GO:0048537)2.91735530
105leukocyte migration involved in inflammatory response (GO:0002523)2.90616575
106detection of biotic stimulus (GO:0009595)2.89282996
107translational termination (GO:0006415)2.89086188
108* negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88914613
109megakaryocyte development (GO:0035855)2.88691804
110positive regulation of protein deacetylation (GO:0090312)2.87016037
111regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86034032
112regulation of natural killer cell mediated immunity (GO:0002715)2.86034032
113* lymphocyte homeostasis (GO:0002260)2.85147861
114positive regulation of humoral immune response (GO:0002922)2.84606133
115positive regulation of tolerance induction (GO:0002645)2.83724340
116myeloid dendritic cell activation (GO:0001773)2.83201017
117response to type I interferon (GO:0034340)2.83057275
118morphogenesis of an endothelium (GO:0003159)2.82891824
119endothelial tube morphogenesis (GO:0061154)2.82891824
120regulation of T cell receptor signaling pathway (GO:0050856)2.81368222
121natural killer cell activation (GO:0030101)2.81006988
122mast cell activation (GO:0045576)2.79158802
123definitive hemopoiesis (GO:0060216)2.76039646
124cellular response to type I interferon (GO:0071357)2.75718730
125type I interferon signaling pathway (GO:0060337)2.75718730
126response to protozoan (GO:0001562)2.73158304
127leukocyte cell-cell adhesion (GO:0007159)2.72388379
128positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.70568269
129positive regulation of natural killer cell mediated immunity (GO:0002717)2.70568269
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.70053829
131positive regulation of B cell mediated immunity (GO:0002714)2.68551341
132positive regulation of immunoglobulin mediated immune response (GO:0002891)2.68551341
133positive regulation of immunoglobulin production (GO:0002639)2.65242405
134CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.65179371
135activated T cell proliferation (GO:0050798)2.64403124
136myeloid dendritic cell differentiation (GO:0043011)2.63827703
137positive regulation of defense response to virus by host (GO:0002230)2.62409604
138immunoglobulin mediated immune response (GO:0016064)2.61836645
139T cell proliferation (GO:0042098)2.61354297
140regulation of isotype switching (GO:0045191)2.60394726
141positive regulation of granulocyte differentiation (GO:0030854)2.60134529
142* leukocyte homeostasis (GO:0001776)2.59477276
143mature B cell differentiation involved in immune response (GO:0002313)2.57043229
144regulation of leukocyte mediated cytotoxicity (GO:0001910)2.56912952
145positive regulation of DNA recombination (GO:0045911)2.56594774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.49472890
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.13481414
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.02332968
4MYC_22102868_ChIP-Seq_BL_Human3.87347286
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.41353016
6VDR_21846776_ChIP-Seq_THP-1_Human3.02722985
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.00943157
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86149844
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79320317
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.78345072
11SCL_19346495_ChIP-Seq_HPC-7_Human2.69353956
12MAF_26560356_Chip-Seq_TH1_Human2.59366539
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.47447061
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47043972
15MYB_26560356_Chip-Seq_TH2_Human2.46734622
16* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.40831044
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38741872
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.36685811
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36235717
20RUNX_20019798_ChIP-Seq_JUKART_Human2.34792135
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32623721
22MYB_26560356_Chip-Seq_TH1_Human2.31385815
23UTX_26944678_Chip-Seq_JUKART_Human2.26745394
24TCF7_22412390_ChIP-Seq_EML_Mouse2.26006553
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.21679327
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21291534
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05683324
28VDR_24763502_ChIP-Seq_THP-1_Human2.00468521
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.92036817
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.88934406
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.86408784
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86092791
33SPI1_23547873_ChIP-Seq_NB4_Human1.85572263
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85177850
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84410929
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84090868
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.84008827
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.83203552
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80929312
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78944423
41* MAF_26560356_Chip-Seq_TH2_Human1.78661968
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75736347
43KDM2B_26808549_Chip-Seq_DND41_Human1.74797961
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72982068
45CIITA_25753668_ChIP-Seq_RAJI_Human1.71251773
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70784196
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.66893348
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.64782835
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62519620
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60785760
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54407371
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50311834
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45148130
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.41841532
55SPI1_23127762_ChIP-Seq_K562_Human1.41840892
56VDR_24787735_ChIP-Seq_THP-1_Human1.40489812
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.38453760
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35999599
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34785365
60GATA3_27048872_Chip-Seq_THYMUS_Human1.34725452
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.33190926
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32218158
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30866389
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30479891
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23396026
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22984988
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22923808
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20841693
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18840090
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17732575
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16770335
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16383967
73* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14107988
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12108761
75NCOR1_26117541_ChIP-Seq_K562_Human1.11803755
76* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11623724
77* FOXP3_21729870_ChIP-Seq_TREG_Human1.09711172
78LXR_22292898_ChIP-Seq_THP-1_Human1.09690640
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09684318
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09622984
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05839466
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05717630
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.04714540
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03086640
85* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02102718
86PU_27001747_Chip-Seq_BMDM_Mouse1.01218736
87KDM2B_26808549_Chip-Seq_JURKAT_Human1.00911865
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99828178
89VDR_23849224_ChIP-Seq_CD4+_Human0.99622174
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98544475
91XRN2_22483619_ChIP-Seq_HELA_Human0.98333953
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97001250
93GATA1_22025678_ChIP-Seq_K562_Human0.95111953
94CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94626503
95BCOR_27268052_Chip-Seq_Bcells_Human0.94220533
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93743105
97* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93563136
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93141932
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92391047
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92223867
101E2F1_21310950_ChIP-Seq_MCF-7_Human0.90455553
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90368662
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89738548
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.89030077
105IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88375466
106* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87345413
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87040002
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86664003
109ELF1_20517297_ChIP-Seq_JURKAT_Human0.85560802
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85556984
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84843337
112* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84211573
113MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83656191
114GATA3_26560356_Chip-Seq_TH2_Human0.83265520
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83122680
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83018711
117RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81415019
118GATA1_19941826_ChIP-Seq_K562_Human0.81003972
119RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80782622
120SPI1_20517297_ChIP-Seq_HL60_Human0.80571172
121MYC_19030024_ChIP-ChIP_MESCs_Mouse0.80428431
122BCL6_27268052_Chip-Seq_Bcells_Human0.79988314
123KDM5A_27292631_Chip-Seq_BREAST_Human0.77863305
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.75481036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.81895931
2MP0000685_abnormal_immune_system3.44758389
3MP0001835_abnormal_antigen_presentation3.32931201
4* MP0001800_abnormal_humoral_immune3.03069595
5MP0005671_abnormal_response_to3.01943152
6* MP0005387_immune_system_phenotype2.80336193
7* MP0001790_abnormal_immune_system2.80336193
8MP0003300_gastrointestinal_ulcer2.79856087
9* MP0002396_abnormal_hematopoietic_system2.76729447
10* MP0002398_abnormal_bone_marrow2.55143976
11MP0003436_decreased_susceptibility_to2.49698271
12* MP0002723_abnormal_immune_serum2.48846167
13* MP0002452_abnormal_antigen_presenting2.46092586
14MP0005000_abnormal_immune_tolerance2.45848188
15* MP0002420_abnormal_adaptive_immunity2.45594453
16MP0001873_stomach_inflammation2.41816836
17* MP0001819_abnormal_immune_cell2.41000039
18MP0003724_increased_susceptibility_to2.36015630
19MP0009785_altered_susceptibility_to2.31845737
20MP0004808_abnormal_hematopoietic_stem2.29543702
21MP0003303_peritoneal_inflammation2.29420022
22* MP0005025_abnormal_response_to2.24212036
23MP0009333_abnormal_splenocyte_physiolog2.22656596
24* MP0000716_abnormal_immune_system2.19372302
25* MP0000689_abnormal_spleen_morphology2.16693916
26MP0002166_altered_tumor_susceptibility2.13483058
27* MP0002722_abnormal_immune_system2.13219297
28MP0002405_respiratory_system_inflammati2.09086687
29* MP0000703_abnormal_thymus_morphology2.04886611
30MP0005464_abnormal_platelet_physiology2.02168870
31* MP0010155_abnormal_intestine_physiology1.99957206
32MP0000465_gastrointestinal_hemorrhage1.95826777
33* MP0002429_abnormal_blood_cell1.93079704
34MP0009278_abnormal_bone_marrow1.91695012
35MP0002419_abnormal_innate_immunity1.85482523
36MP0001545_abnormal_hematopoietic_system1.77758983
37MP0005397_hematopoietic_system_phenotyp1.77758983
38* MP0003866_abnormal_defecation1.75191087
39MP0001853_heart_inflammation1.70272640
40MP0002148_abnormal_hypersensitivity_rea1.70184714
41MP0004510_myositis1.63939717
42MP0002933_joint_inflammation1.63259985
43MP0002006_tumorigenesis1.60553978
44MP0010352_gastrointestinal_tract_polyps1.58206282
45MP0004947_skin_inflammation1.57677511
46* MP0001845_abnormal_inflammatory_respons1.54384993
47MP0000490_abnormal_crypts_of1.52363874
48MP0006082_CNS_inflammation1.51623084
49MP0004381_abnormal_hair_follicle1.40072910
50MP0002132_abnormal_respiratory_system1.31165913
51MP0010368_abnormal_lymphatic_system1.29698663
52MP0008057_abnormal_DNA_replication1.23012514
53MP0002277_abnormal_respiratory_mucosa1.22555820
54MP0008469_abnormal_protein_level1.21608015
55MP0003191_abnormal_cellular_cholesterol1.19134192
56MP0002019_abnormal_tumor_incidence1.17199819
57MP0005075_abnormal_melanosome_morpholog1.15057092
58MP0000858_altered_metastatic_potential1.12658582
59MP0008260_abnormal_autophagy1.11945754
60MP0010094_abnormal_chromosome_stability1.09710727
61MP0001533_abnormal_skeleton_physiology1.08447502
62MP0003077_abnormal_cell_cycle1.06524273
63MP0001851_eye_inflammation1.05512536
64MP0001879_abnormal_lymphatic_vessel1.00729943
65MP0003448_altered_tumor_morphology1.00218347
66MP0008961_abnormal_basal_metabolism0.99227173
67MP0005670_abnormal_white_adipose0.99037330
68MP0005310_abnormal_salivary_gland0.98383584
69MP0003828_pulmonary_edema0.98047167
70MP0005174_abnormal_tail_pigmentation0.97739303
71MP0005451_abnormal_body_composition0.96481477
72MP0004883_abnormal_blood_vessel0.93676716
73MP0005023_abnormal_wound_healing0.91390059
74MP0003183_abnormal_peptide_metabolism0.91296438
75MP0005076_abnormal_cell_differentiation0.90255186
76MP0001986_abnormal_taste_sensitivity0.89532691
77MP0003693_abnormal_embryo_hatching0.87986373
78MP0003566_abnormal_cell_adhesion0.87269605
79MP0005166_decreased_susceptibility_to0.86318939
80MP0003111_abnormal_nucleus_morphology0.84078861
81MP0002009_preneoplasia0.83591999
82MP0006054_spinal_hemorrhage0.81884865
83MP0003075_altered_response_to0.81681968
84MP0009763_increased_sensitivity_to0.80605236
85MP0000609_abnormal_liver_physiology0.79234256
86MP0009840_abnormal_foam_cell0.78151767
87MP0005390_skeleton_phenotype0.76407265
88MP0000343_altered_response_to0.75990374
89MP0002138_abnormal_hepatobiliary_system0.75834633
90MP0008007_abnormal_cellular_replicative0.75701980
91MP0010307_abnormal_tumor_latency0.75207393
92MP0000313_abnormal_cell_death0.72157929
93MP0004957_abnormal_blastocyst_morpholog0.70657436
94MP0000015_abnormal_ear_pigmentation0.70301446
95MP0004185_abnormal_adipocyte_glucose0.70204405
96* MP0000477_abnormal_intestine_morphology0.67833072
97MP0009764_decreased_sensitivity_to0.67612248
98MP0003172_abnormal_lysosome_physiology0.66836706
99MP0000249_abnormal_blood_vessel0.65971136
100MP0000598_abnormal_liver_morphology0.65325762
101MP0002693_abnormal_pancreas_physiology0.65222553
102MP0008058_abnormal_DNA_repair0.65084906
103MP0000350_abnormal_cell_proliferation0.64458996
104MP0005164_abnormal_response_to0.64365716
105MP0001663_abnormal_digestive_system0.62844331
106MP0002998_abnormal_bone_remodeling0.62595560
107MP0002086_abnormal_extraembryonic_tissu0.62525084
108MP0005666_abnormal_adipose_tissue0.61330729
109MP0003806_abnormal_nucleotide_metabolis0.60466741
110MP0003045_fibrosis0.58477884
111MP0003795_abnormal_bone_structure0.58048080
112MP0002088_abnormal_embryonic_growth/wei0.57972969
113MP0003943_abnormal_hepatobiliary_system0.57832434
114MP0000604_amyloidosis0.57237235
115MP0003984_embryonic_growth_retardation0.56677903
116MP0009765_abnormal_xenobiotic_induced0.56316037
117MP0001915_intracranial_hemorrhage0.56283332
118MP0002254_reproductive_system_inflammat0.56262714
119MP0008873_increased_physiological_sensi0.55337225
120MP0008004_abnormal_stomach_pH0.52393596
121MP0003690_abnormal_glial_cell0.49976625
122MP0005381_digestive/alimentary_phenotyp0.49787095
123MP0008874_decreased_physiological_sensi0.48643698
124MP0001348_abnormal_lacrimal_gland0.46639155
125MP0004130_abnormal_muscle_cell0.44765098
126MP0002136_abnormal_kidney_physiology0.43578387
127MP0005319_abnormal_enzyme/_coenzyme0.43246533
128MP0003252_abnormal_bile_duct0.41595131
129MP0005058_abnormal_lysosome_morphology0.40592574
130MP0002928_abnormal_bile_duct0.40366436

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.21930703
2IgM deficiency (HP:0002850)5.21569087
3Nasal polyposis (HP:0100582)4.62114248
4Abnormality of the nasal mucosa (HP:0000433)4.58043997
5Recurrent bronchitis (HP:0002837)4.55734024
6Elevated erythrocyte sedimentation rate (HP:0003565)4.50622127
7Recurrent viral infections (HP:0004429)4.30227627
8Recurrent fungal infections (HP:0002841)4.23980450
9T lymphocytopenia (HP:0005403)4.22456932
10Abnormality of macrophages (HP:0004311)4.21885372
11Myositis (HP:0100614)4.09606410
12Gastrointestinal infarctions (HP:0005244)4.05991030
13Abnormality of T cell number (HP:0011839)3.98063714
14Thrombocytosis (HP:0001894)3.93923252
15Inflammation of the large intestine (HP:0002037)3.92552942
16Spontaneous hematomas (HP:0007420)3.90171627
17Gastrointestinal inflammation (HP:0004386)3.90136630
18Recurrent cutaneous fungal infections (HP:0011370)3.73795335
19Chronic mucocutaneous candidiasis (HP:0002728)3.73795335
20Keratoconjunctivitis sicca (HP:0001097)3.65550992
21Abnormality of the fingertips (HP:0001211)3.61245465
22Eczematoid dermatitis (HP:0000976)3.59100532
23Recurrent gram-negative bacterial infections (HP:0005420)3.58232031
24* Abnormality of T cells (HP:0002843)3.53829397
25Keratoconjunctivitis (HP:0001096)3.47990490
26Prolonged bleeding time (HP:0003010)3.42391236
27Pustule (HP:0200039)3.37957744
28Colitis (HP:0002583)3.27401879
29Increased IgM level (HP:0003496)3.11344808
30Agammaglobulinemia (HP:0004432)3.07043623
31Cellulitis (HP:0100658)3.06972551
32Increased IgE level (HP:0003212)3.05749830
33Lymphopenia (HP:0001888)3.03805804
34IgA deficiency (HP:0002720)3.00432850
35Hypochromic anemia (HP:0001931)2.97428052
36Chronic diarrhea (HP:0002028)2.96490813
37Epistaxis (HP:0000421)2.94716041
38Abnormality of cells of the lymphoid lineage (HP:0012140)2.94633484
39Recurrent abscess formation (HP:0002722)2.85470874
40Urticaria (HP:0001025)2.85073061
41Vasculitis (HP:0002633)2.83119394
42Gingivitis (HP:0000230)2.82725316
43* Abnormality of T cell physiology (HP:0011840)2.81849615
44* Abnormal delayed hypersensitivity skin test (HP:0002963)2.81420568
45Interstitial pulmonary disease (HP:0006530)2.77936864
46* Meningitis (HP:0001287)2.76411119
47Gastrointestinal stroma tumor (HP:0100723)2.75525318
48B lymphocytopenia (HP:0010976)2.74996442
49Abnormality of B cell number (HP:0010975)2.74996442
50Hypochromic microcytic anemia (HP:0004840)2.70633971
51Hemoptysis (HP:0002105)2.66534384
52Recurrent skin infections (HP:0001581)2.66378436
53Verrucae (HP:0200043)2.66362384
54Papilloma (HP:0012740)2.66362384
55Stomatitis (HP:0010280)2.66058102
56Chronic sinusitis (HP:0011109)2.66010221
57Abnormal platelet volume (HP:0011876)2.66008232
58Chest pain (HP:0100749)2.65546140
59Autoimmune thrombocytopenia (HP:0001973)2.64035220
60IgG deficiency (HP:0004315)2.63577678
61* Panhypogammaglobulinemia (HP:0003139)2.62602040
62Emphysema (HP:0002097)2.61481138
63Basal cell carcinoma (HP:0002671)2.59140182
64Anorexia (HP:0002039)2.58535697
65Lymphoma (HP:0002665)2.57274693
66Recurrent sinusitis (HP:0011108)2.56358619
67Gingival bleeding (HP:0000225)2.56268274
68Abnormality of the pleura (HP:0002103)2.53529231
69Petechiae (HP:0000967)2.52588629
70Abnormal platelet function (HP:0011869)2.50258913
71Impaired platelet aggregation (HP:0003540)2.50258913
72Gangrene (HP:0100758)2.49578888
73Combined immunodeficiency (HP:0005387)2.49479535
74Mediastinal lymphadenopathy (HP:0100721)2.48458306
75Papilledema (HP:0001085)2.48097372
76Arterial thrombosis (HP:0004420)2.47214455
77Orchitis (HP:0100796)2.44069319
78Severe combined immunodeficiency (HP:0004430)2.43578768
79Bronchitis (HP:0012387)2.43208955
80Recurrent bacterial skin infections (HP:0005406)2.41057961
81Eosinophilia (HP:0001880)2.38338960
82Episodic fever (HP:0001954)2.35860597
83Granulocytopenia (HP:0001913)2.35349969
84Increased density of long bones (HP:0006392)2.34964470
85Leukocytosis (HP:0001974)2.33788828
86Hematochezia (HP:0002573)2.32787187
87Encephalitis (HP:0002383)2.32180005
88Reticulocytopenia (HP:0001896)2.29977815
89Abnormality of the prostate (HP:0008775)2.29042872
90Joint swelling (HP:0001386)2.28609255
91Abnormality of eosinophils (HP:0001879)2.25565293
92Pulmonary infiltrates (HP:0002113)2.23523819
93Acute myeloid leukemia (HP:0004808)2.21614049
94Cheilitis (HP:0100825)2.20526604
95Amaurosis fugax (HP:0100576)2.19991588
96Obstructive lung disease (HP:0006536)2.19126757
97Chronic obstructive pulmonary disease (HP:0006510)2.19126757
98Sepsis (HP:0100806)2.18920147
99Stomach cancer (HP:0012126)2.17631636
100Pulmonary embolism (HP:0002204)2.16662218
101Poikiloderma (HP:0001029)2.16420647
102Retrobulbar optic neuritis (HP:0100654)2.15757458
103Optic neuritis (HP:0100653)2.15757458
104Keratitis (HP:0000491)2.14700241
105Skin ulcer (HP:0200042)2.14643862
106Acute hepatic failure (HP:0006554)2.12458563
107Premature loss of primary teeth (HP:0006323)2.12167027
108Glomerulopathy (HP:0100820)2.10650634
109Increased mean platelet volume (HP:0011877)2.08185279
110Fatigue (HP:0012378)2.06040696
111Abnormality of cells of the erythroid lineage (HP:0012130)2.04957539
112Skin rash (HP:0000988)2.04302434
113Periodontitis (HP:0000704)2.03943532
114Thyroiditis (HP:0100646)2.02247592
115Microcytic anemia (HP:0001935)2.01795628
116Restrictive lung disease (HP:0002091)1.96448398
117Abnormal number of erythroid precursors (HP:0012131)1.96011641
118Abnormality of the endocardium (HP:0004306)1.95958525
119Polyneuropathy (HP:0001271)1.94889515
120Hypergammaglobulinemia (HP:0010702)1.93895975
121Persistence of primary teeth (HP:0006335)1.93754579
122Polycythemia (HP:0001901)1.93713969
123Leukopenia (HP:0001882)1.93515490
124Viral hepatitis (HP:0006562)1.93151518
125Arthralgia (HP:0002829)1.91636906
126Hyperacusis (HP:0010780)1.87596657
127Autoimmune hemolytic anemia (HP:0001890)1.86594619
128Osteomyelitis (HP:0002754)1.81085303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.69012219
2RIPK43.87067552
3EEF2K3.57225829
4TXK2.90179110
5KDR2.47591642
6PKN22.47026657
7TYK22.34194508
8ZAP702.33950979
9FGFR42.28570790
10TRIB32.23999651
11* JAK32.22682482
12MAP3K102.14882038
13STK102.14522271
14PRPF4B2.10624761
15GRK61.92702905
16KIT1.88457593
17BTK1.85724214
18ITK1.82325061
19TGFBR21.82306107
20BLK1.79169355
21JAK11.71369657
22FLT31.69991467
23CSF1R1.68620624
24ERN11.64515089
25EPHB11.61240792
26IKBKE1.54751915
27TIE11.51191044
28TEC1.49323408
29TBK11.47802088
30MAP2K31.45469024
31CDK121.43777550
32MAP3K141.43662398
33TGFBR11.42179950
34SIK21.39942069
35FGFR31.37220559
36SYK1.36504899
37* LCK1.35419494
38NLK1.33346287
39LRRK21.32904222
40HCK1.25194176
41NME21.24021258
42CLK11.20920827
43CSK1.15974371
44MAP3K31.07166321
45SIK11.06475583
46CDK41.03852560
47FES1.03148648
48EPHA31.03092935
49IKBKB1.02984003
50FGR1.02205790
51PIM11.01651550
52BMPR21.01083697
53JAK20.99825429
54PTK60.98177509
55IRAK40.96792856
56MAP3K70.94777771
57TTN0.92470078
58NEK20.90449365
59RPS6KA40.86754071
60MAP3K130.85645086
61MAP3K10.84082185
62MARK30.83571192
63SMG10.81279941
64CAMKK20.80654653
65RPS6KB20.79581656
66LYN0.76755485
67MAP2K60.76125763
68CHUK0.75890976
69TNK20.74165973
70IRAK30.73706792
71CAMKK10.71023964
72ALK0.68691323
73HIPK20.67148957
74SIK30.66926765
75PASK0.66674767
76MATK0.66247249
77TAOK30.65991933
78PRKCH0.64856036
79CDC42BPA0.63428244
80MAPK70.63248561
81CDC70.60746360
82PIK3CG0.60651806
83FYN0.60198480
84PRKCQ0.56679089
85YES10.55853148
86CDK90.52602773
87MAP3K110.52334652
88CAMK1D0.51219011
89BRD40.50758364
90TSSK60.49335601
91MAP3K80.49112708
92PRKD20.48358962
93MAPK110.47669334
94STK40.46459238
95CDK60.46095458
96TAOK20.45877996
97PDK10.45853183
98MAPK40.44246504
99GRK70.43983606
100MARK20.41934622
101PTK2B0.41247273
102STK110.40284974
103MAP2K20.40266192
104RPS6KA60.40216576
105PDPK10.38837579
106TAOK10.38775025
107PIM20.37462598
108TRPM70.37438523
109MAPKAPK20.35454349
110ATR0.35142792
111IRAK20.34484012
112MTOR0.34461721
113MELK0.33902776
114CDK70.32557164
115RPS6KC10.31657211
116RPS6KL10.31657211
117MAPK30.29633777
118CAMK1G0.29121096
119RET0.29023799
120KSR20.28811360
121EGFR0.27452521
122RIPK10.27219131
123MAP3K50.26034535
124PAK40.25656189
125SGK30.25244486
126MAPK120.25179602
127TESK20.25171170
128IRAK10.25109993
129CDK190.24856736
130ABL10.24694242
131PRKCD0.23224756

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary immunodeficiency_Homo sapiens_hsa053403.99292639
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.92646759
3B cell receptor signaling pathway_Homo sapiens_hsa046622.70878272
4T cell receptor signaling pathway_Homo sapiens_hsa046602.62026209
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.58908061
6Type I diabetes mellitus_Homo sapiens_hsa049402.52298527
7* Measles_Homo sapiens_hsa051622.36393958
8Antigen processing and presentation_Homo sapiens_hsa046122.29905962
9DNA replication_Homo sapiens_hsa030302.25661931
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.21977666
11Osteoclast differentiation_Homo sapiens_hsa043802.10162589
12Leishmaniasis_Homo sapiens_hsa051402.09799480
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09001144
14Hematopoietic cell lineage_Homo sapiens_hsa046402.08579492
15* Jak-STAT signaling pathway_Homo sapiens_hsa046301.91905134
16Acute myeloid leukemia_Homo sapiens_hsa052211.91675632
17Herpes simplex infection_Homo sapiens_hsa051681.76779929
18Ribosome_Homo sapiens_hsa030101.72144409
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68324969
20Mismatch repair_Homo sapiens_hsa034301.58600188
21Base excision repair_Homo sapiens_hsa034101.56206049
22Toxoplasmosis_Homo sapiens_hsa051451.50829158
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48347012
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46018450
25Viral myocarditis_Homo sapiens_hsa054161.42624635
26Chronic myeloid leukemia_Homo sapiens_hsa052201.41968256
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35367359
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.32559488
29Hepatitis B_Homo sapiens_hsa051611.31950560
30Allograft rejection_Homo sapiens_hsa053301.28802046
31Influenza A_Homo sapiens_hsa051641.26019389
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25695380
33Rheumatoid arthritis_Homo sapiens_hsa053231.23695816
34Platelet activation_Homo sapiens_hsa046111.20285649
35Apoptosis_Homo sapiens_hsa042101.16365406
36Staphylococcus aureus infection_Homo sapiens_hsa051501.15088494
37TNF signaling pathway_Homo sapiens_hsa046681.15029219
38* HTLV-I infection_Homo sapiens_hsa051661.13555279
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12582427
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12154038
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12135401
42* Chemokine signaling pathway_Homo sapiens_hsa040621.11188964
43Shigellosis_Homo sapiens_hsa051311.09781528
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09489423
45Pancreatic cancer_Homo sapiens_hsa052121.07304436
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05697031
47Spliceosome_Homo sapiens_hsa030401.04207056
48Malaria_Homo sapiens_hsa051441.03809533
49African trypanosomiasis_Homo sapiens_hsa051431.03047116
50One carbon pool by folate_Homo sapiens_hsa006700.99889875
51Notch signaling pathway_Homo sapiens_hsa043300.98086654
52* Epstein-Barr virus infection_Homo sapiens_hsa051690.95389043
53Legionellosis_Homo sapiens_hsa051340.95018123
54Small cell lung cancer_Homo sapiens_hsa052220.94314118
55Prolactin signaling pathway_Homo sapiens_hsa049170.93092799
56VEGF signaling pathway_Homo sapiens_hsa043700.91820217
57* Viral carcinogenesis_Homo sapiens_hsa052030.88131007
58Graft-versus-host disease_Homo sapiens_hsa053320.87223819
59Non-homologous end-joining_Homo sapiens_hsa034500.86210101
60Hepatitis C_Homo sapiens_hsa051600.85020857
61Non-small cell lung cancer_Homo sapiens_hsa052230.83444381
62Lysine degradation_Homo sapiens_hsa003100.82365264
63Tuberculosis_Homo sapiens_hsa051520.80464647
64Phagosome_Homo sapiens_hsa041450.79570656
65Homologous recombination_Homo sapiens_hsa034400.77401685
66Insulin resistance_Homo sapiens_hsa049310.76304280
67Pertussis_Homo sapiens_hsa051330.76108956
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.74565634
69Autoimmune thyroid disease_Homo sapiens_hsa053200.74020708
70Asthma_Homo sapiens_hsa053100.72837126
71HIF-1 signaling pathway_Homo sapiens_hsa040660.72382401
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71538289
73Colorectal cancer_Homo sapiens_hsa052100.71149135
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69623865
75Nucleotide excision repair_Homo sapiens_hsa034200.69572264
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63847603
77p53 signaling pathway_Homo sapiens_hsa041150.63596223
78RNA transport_Homo sapiens_hsa030130.62510671
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.61961175
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61684514
81Other glycan degradation_Homo sapiens_hsa005110.61659779
82Cell cycle_Homo sapiens_hsa041100.58805398
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57492285
84ABC transporters_Homo sapiens_hsa020100.56647872
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55453793
86RNA degradation_Homo sapiens_hsa030180.54871994
87Caffeine metabolism_Homo sapiens_hsa002320.53443222
88Endocytosis_Homo sapiens_hsa041440.51196471
89Salmonella infection_Homo sapiens_hsa051320.49674545
90Dorso-ventral axis formation_Homo sapiens_hsa043200.49111028
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48721651
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.48427312
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.48060208
94mTOR signaling pathway_Homo sapiens_hsa041500.47003814
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46777722
96Choline metabolism in cancer_Homo sapiens_hsa052310.46478200
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45916217
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45112938
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44726472
100MAPK signaling pathway_Homo sapiens_hsa040100.44351519
101mRNA surveillance pathway_Homo sapiens_hsa030150.44320664
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.44110571
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.42836461
104Thyroid cancer_Homo sapiens_hsa052160.42736828
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41576356
106Renal cell carcinoma_Homo sapiens_hsa052110.41473833
107Pentose phosphate pathway_Homo sapiens_hsa000300.39646916
108Pathways in cancer_Homo sapiens_hsa052000.39574542
109MicroRNAs in cancer_Homo sapiens_hsa052060.39564787
110Regulation of autophagy_Homo sapiens_hsa041400.39155658
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39146122
112Fanconi anemia pathway_Homo sapiens_hsa034600.38725323
113Pyrimidine metabolism_Homo sapiens_hsa002400.38278225
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37922849
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37598058
116FoxO signaling pathway_Homo sapiens_hsa040680.36414061
117Sulfur relay system_Homo sapiens_hsa041220.36316938
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35528124
119Systemic lupus erythematosus_Homo sapiens_hsa053220.33986934
120Inositol phosphate metabolism_Homo sapiens_hsa005620.32305513
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31788508
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30362887
123Endometrial cancer_Homo sapiens_hsa052130.29658847
124Lysosome_Homo sapiens_hsa041420.26800680
125GnRH signaling pathway_Homo sapiens_hsa049120.24682648
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23588728
127Type II diabetes mellitus_Homo sapiens_hsa049300.23411914
128Ras signaling pathway_Homo sapiens_hsa040140.23408935
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21905270
130Prostate cancer_Homo sapiens_hsa052150.20182950
131Rap1 signaling pathway_Homo sapiens_hsa040150.17362964
132Arachidonic acid metabolism_Homo sapiens_hsa005900.17058724
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.15005498

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