JAM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.50589220
2* ensheathment of neurons (GO:0007272)7.19908375
3* axon ensheathment (GO:0008366)7.19908375
4* myelination (GO:0042552)7.16375601
5long-chain fatty acid biosynthetic process (GO:0042759)5.75643788
6negative regulation of neurotransmitter secretion (GO:0046929)5.21355600
7myelin maintenance (GO:0043217)5.16497215
8cholesterol biosynthetic process (GO:0006695)4.93187007
9oligodendrocyte differentiation (GO:0048709)4.86532099
10negative regulation of neurotransmitter transport (GO:0051589)4.65184780
11apical protein localization (GO:0045176)4.53818774
12regulation of collateral sprouting (GO:0048670)4.52266494
13asymmetric protein localization (GO:0008105)4.51863346
14eye photoreceptor cell differentiation (GO:0001754)4.51699391
15photoreceptor cell differentiation (GO:0046530)4.51699391
16astrocyte development (GO:0014002)4.50298364
17glycerophospholipid catabolic process (GO:0046475)4.44256985
18negative regulation of protein localization to cell surface (GO:2000009)4.40180000
19peripheral nervous system axon ensheathment (GO:0032292)4.37144139
20myelination in peripheral nervous system (GO:0022011)4.37144139
21sterol biosynthetic process (GO:0016126)4.33424783
22creatine metabolic process (GO:0006600)4.28079826
23substantia nigra development (GO:0021762)4.17218362
24establishment of mitochondrion localization (GO:0051654)4.07639398
25positive regulation of oligodendrocyte differentiation (GO:0048714)4.06304344
26adhesion of symbiont to host cell (GO:0044650)4.04562634
27virion attachment to host cell (GO:0019062)4.04562634
28response to redox state (GO:0051775)3.96623664
29peptidyl-tyrosine autophosphorylation (GO:0038083)3.93539650
30negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.90100740
31presynaptic membrane organization (GO:0097090)3.86016872
32isoprenoid biosynthetic process (GO:0008299)3.79879010
33presynaptic membrane assembly (GO:0097105)3.77821000
34L-amino acid import (GO:0043092)3.76610393
35limb bud formation (GO:0060174)3.63366563
36long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.57290871
37positive regulation of action potential (GO:0045760)3.52932722
38axonal fasciculation (GO:0007413)3.42677203
39postsynaptic membrane organization (GO:0001941)3.41310544
40cerebral cortex radially oriented cell migration (GO:0021799)3.40119957
41negative regulation of axonogenesis (GO:0050771)3.36078598
42protein palmitoylation (GO:0018345)3.34505079
43import into cell (GO:0098657)3.30191853
44long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.27855594
45amyloid precursor protein metabolic process (GO:0042982)3.27469691
46magnesium ion transport (GO:0015693)3.27182502
47nucleotide transmembrane transport (GO:1901679)3.23210326
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.20545975
49axon extension involved in axon guidance (GO:0048846)3.20545975
50endothelium development (GO:0003158)3.20179325
51GPI anchor biosynthetic process (GO:0006506)3.19184645
52lateral sprouting from an epithelium (GO:0060601)3.19070926
53response to methylmercury (GO:0051597)3.17573398
54negative regulation of axon extension (GO:0030517)3.17408054
55neuron cell-cell adhesion (GO:0007158)3.16461723
56pyrimidine nucleobase catabolic process (GO:0006208)3.14769154
57preassembly of GPI anchor in ER membrane (GO:0016254)3.14087961
58response to lipoprotein particle (GO:0055094)3.11397854
59GPI anchor metabolic process (GO:0006505)3.06509916
60glial cell development (GO:0021782)3.05862435
61cellular response to epinephrine stimulus (GO:0071872)3.04875396
62adhesion of symbiont to host (GO:0044406)3.01073274
63fatty-acyl-CoA biosynthetic process (GO:0046949)2.99806608
64neuron recognition (GO:0008038)2.99603621
65paraxial mesoderm development (GO:0048339)2.98056197
66amino acid import (GO:0043090)2.96661466
67peripheral nervous system development (GO:0007422)2.93784114
68adult walking behavior (GO:0007628)2.91999093
69enteric nervous system development (GO:0048484)2.90615843
70neural nucleus development (GO:0048857)2.88827004
71membrane tubulation (GO:0097320)2.88657731
72negative regulation of JUN kinase activity (GO:0043508)2.87860132
73cellular response to hepatocyte growth factor stimulus (GO:0035729)2.85868951
74response to hepatocyte growth factor (GO:0035728)2.85868951
75lymphangiogenesis (GO:0001946)2.83712928
76glycosylceramide metabolic process (GO:0006677)2.81213969
77fatty-acyl-CoA metabolic process (GO:0035337)2.79774771
78very long-chain fatty acid metabolic process (GO:0000038)2.78301236
79positive regulation of glial cell differentiation (GO:0045687)2.78228396
80organ growth (GO:0035265)2.77121202
81neuronal stem cell maintenance (GO:0097150)2.76313140
82response to epinephrine (GO:0071871)2.75512267
83axon development (GO:0061564)2.75094582
84Leydig cell differentiation (GO:0033327)2.74724687
85Notch signaling involved in heart development (GO:0061314)2.73649027
86neuronal ion channel clustering (GO:0045161)2.73097588
87glial cell differentiation (GO:0010001)2.72014458
88negative chemotaxis (GO:0050919)2.70757467
89outer ear morphogenesis (GO:0042473)2.67962655
90retinal ganglion cell axon guidance (GO:0031290)2.67817463
91ear development (GO:0043583)2.67425186
92protein neddylation (GO:0045116)2.67149344
93dendritic spine morphogenesis (GO:0060997)2.66010777
94ganglion development (GO:0061548)2.64737969
95Golgi to plasma membrane protein transport (GO:0043001)2.64281266
96negative regulation of myoblast differentiation (GO:0045662)2.62205667
97regulation of somitogenesis (GO:0014807)2.61807384
98artery development (GO:0060840)2.60855861
99lymph vessel development (GO:0001945)2.60152879
100peptidyl-cysteine modification (GO:0018198)2.58559582
101response to lead ion (GO:0010288)2.56826357
102nerve growth factor signaling pathway (GO:0038180)2.56399930
103regulation of lipoprotein metabolic process (GO:0050746)2.55223301
104positive regulation of gliogenesis (GO:0014015)2.53953089
105cranial nerve development (GO:0021545)2.52239369
106microtubule polymerization or depolymerization (GO:0031109)2.51963432
107neuron remodeling (GO:0016322)2.51958410
108mannosylation (GO:0097502)2.50603754
109regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.49288043
110neurotransmitter uptake (GO:0001504)2.47909256
111cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.47603673
112regulation of oligodendrocyte differentiation (GO:0048713)2.47509392
113negative regulation of axon guidance (GO:1902668)2.47223263
114cellular response to monoamine stimulus (GO:0071868)2.46994174
115cellular response to catecholamine stimulus (GO:0071870)2.46994174
116positive regulation of actin filament depolymerization (GO:0030836)2.46509879
117epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.46206115
118neuronal action potential propagation (GO:0019227)2.45397972
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44714900
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.41255976
121appendage development (GO:0048736)2.39740529
122limb development (GO:0060173)2.39740529
123vocalization behavior (GO:0071625)2.38454782
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37127278
125cell migration involved in sprouting angiogenesis (GO:0002042)2.36999520
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.35112576
127axon extension (GO:0048675)2.34939001
128spinal cord association neuron differentiation (GO:0021527)2.33870515
129forebrain neuron differentiation (GO:0021879)2.30211225
130negative regulation of chondrocyte differentiation (GO:0032331)2.29435017
131tongue development (GO:0043586)2.29393261
132cell-cell signaling involved in cell fate commitment (GO:0045168)2.29112833
133nucleobase catabolic process (GO:0046113)2.29077937
134chondrocyte proliferation (GO:0035988)2.28750068
135negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.25973835
136ventricular trabecula myocardium morphogenesis (GO:0003222)2.25533174
137regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.25455822
138developmental induction (GO:0031128)2.24385788
139endocardial cushion morphogenesis (GO:0003203)2.24042191
140positive regulation of synapse assembly (GO:0051965)2.23834932
141vascular endothelial growth factor signaling pathway (GO:0038084)2.22808365
142regulation of synapse structural plasticity (GO:0051823)2.22449768
143regulation of non-canonical Wnt signaling pathway (GO:2000050)2.22328538
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21480949
145establishment of nucleus localization (GO:0040023)2.20819850
146ephrin receptor signaling pathway (GO:0048013)2.19234524
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.17910491
148camera-type eye morphogenesis (GO:0048593)2.17560014
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.17236726
150regulation of integrin-mediated signaling pathway (GO:2001044)2.17012420
151membrane assembly (GO:0071709)2.16246220
152cell proliferation in forebrain (GO:0021846)2.14805982
153blood vessel maturation (GO:0001955)2.12071201
154otic vesicle formation (GO:0030916)2.11987203
155regulation of axon guidance (GO:1902667)2.11850821
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.10800318
157negative regulation of oligodendrocyte differentiation (GO:0048715)2.09290872
158neuromuscular synaptic transmission (GO:0007274)2.08998751
159notochord development (GO:0030903)2.08923226
160mesenchyme morphogenesis (GO:0072132)2.07628114
161lung-associated mesenchyme development (GO:0060484)2.07256504
162nonmotile primary cilium assembly (GO:0035058)2.06275145
163intraciliary transport (GO:0042073)2.05280052
164atrial cardiac muscle cell action potential (GO:0086014)2.04538450
165regulation of synapse assembly (GO:0051963)2.04320526
166organ induction (GO:0001759)2.04179157
167olfactory bulb development (GO:0021772)2.03596058
168dendrite morphogenesis (GO:0048813)2.03579408
169radial glial cell differentiation (GO:0060019)2.03132573
170central nervous system projection neuron axonogenesis (GO:0021952)2.01725231
171response to gravity (GO:0009629)2.01541931
172behavioral response to nicotine (GO:0035095)2.00930432
173dermatan sulfate biosynthetic process (GO:0030208)2.00673177
174positive regulation of neural precursor cell proliferation (GO:2000179)2.00261742
175central nervous system myelination (GO:0022010)11.2701839
176axon ensheathment in central nervous system (GO:0032291)11.2701839
177protein localization to synapse (GO:0035418)1.99161713
178neuron fate commitment (GO:0048663)1.98384219
179regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.98292678
180heart valve formation (GO:0003188)1.98274504
181G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.98061435
182cardiac myofibril assembly (GO:0055003)1.96288412
183cerebral cortex cell migration (GO:0021795)1.94898526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.40500875
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95247856
3SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.87032324
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.47194020
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.42275348
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36362153
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32930833
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31353716
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.24382186
10TAF15_26573619_Chip-Seq_HEK293_Human2.24110335
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23470568
12EZH2_22144423_ChIP-Seq_EOC_Human2.20941157
13* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.17080534
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13542678
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12725919
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12725919
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05375811
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99510629
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.96286422
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92469603
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92001569
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.90226516
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88874457
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86753124
25AR_21572438_ChIP-Seq_LNCaP_Human1.84994593
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.84859756
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82910887
28* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82562909
29VDR_22108803_ChIP-Seq_LS180_Human1.82357698
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82308483
31ER_23166858_ChIP-Seq_MCF-7_Human1.80792950
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.79971754
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.76958577
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75890159
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75083025
36FUS_26573619_Chip-Seq_HEK293_Human1.71124719
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69851714
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62822081
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.61712561
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.55838125
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55212961
42STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.52499860
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51929302
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50924955
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49822657
46DROSHA_22980978_ChIP-Seq_HELA_Human1.49573694
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48704935
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46968239
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45303493
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.42955453
51SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.41644190
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39149433
53IGF1R_20145208_ChIP-Seq_DFB_Human1.37732668
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36781512
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.35303502
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35122092
57* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34280339
58P300_19829295_ChIP-Seq_ESCs_Human1.32180429
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.31084542
60RNF2_27304074_Chip-Seq_NSC_Mouse1.29912107
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28688192
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28664395
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28644036
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24635084
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24449481
66TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23529924
67* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22510933
68EOMES_21245162_ChIP-Seq_HESCs_Human1.20774559
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19354762
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18862626
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17104155
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15138381
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14767758
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13727533
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13727533
76* STAT3_23295773_ChIP-Seq_U87_Human1.13661050
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13537729
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12907946
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12885390
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12885390
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12630162
82* EP300_21415370_ChIP-Seq_HL-1_Mouse1.12524012
83ZNF274_21170338_ChIP-Seq_K562_Hela1.12006930
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10372849
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10042417
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09646481
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.09607124
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09524343
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.09429953
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08586265
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08451212
92* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08118976
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07684116
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07028203
95* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06885839
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.05718808
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05570331
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04483455
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.04163309
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.04012828
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.02930188
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.02434647
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01935895
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.01209980
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01065946
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00924713
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00788786
108WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00486283
109RARB_27405468_Chip-Seq_BRAIN_Mouse1.00132613
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99361157
111TCF4_23295773_ChIP-Seq_U87_Human0.99354805
112SMAD4_21799915_ChIP-Seq_A2780_Human0.98929675
113EWS_26573619_Chip-Seq_HEK293_Human0.98613263
114RING1B_27294783_Chip-Seq_ESCs_Mouse0.98401281
115* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98170265
116REST_21632747_ChIP-Seq_MESCs_Mouse0.97775837
117SOX9_26525672_Chip-Seq_HEART_Mouse0.97243039
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96951631
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96935713
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96819265
121P300_18555785_Chip-Seq_ESCs_Mouse0.94753098
122* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94648330
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94117251
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93679853
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92612428
126* TBL1_22424771_ChIP-Seq_293T_Human0.91321061
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90028703
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90028703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.98330197
2MP0003880_abnormal_central_pattern3.55517677
3MP0003950_abnormal_plasma_membrane3.33851091
4MP0004270_analgesia3.08916372
5MP0010368_abnormal_lymphatic_system3.00695113
6MP0005171_absent_coat_pigmentation2.92299674
7MP0001529_abnormal_vocalization2.80433252
8MP0003690_abnormal_glial_cell2.78999361
9MP0003136_yellow_coat_color2.76119357
10MP0004885_abnormal_endolymph2.75619529
11MP0004742_abnormal_vestibular_system2.49424419
12MP0000778_abnormal_nervous_system2.47556548
13MP0003634_abnormal_glial_cell2.39732164
14MP0001905_abnormal_dopamine_level2.38577598
15MP0001485_abnormal_pinna_reflex2.38007974
16MP0003329_amyloid_beta_deposits2.26063335
17MP0002272_abnormal_nervous_system2.20890654
18MP0001486_abnormal_startle_reflex2.20680611
19MP0001879_abnormal_lymphatic_vessel2.04053076
20MP0004142_abnormal_muscle_tone1.90698031
21MP0000462_abnormal_digestive_system1.88410454
22MP0002064_seizures1.82281413
23MP0000049_abnormal_middle_ear1.82163214
24MP0003632_abnormal_nervous_system1.74029539
25MP0005409_darkened_coat_color1.73596465
26MP0000566_synostosis1.71579712
27MP0005623_abnormal_meninges_morphology1.69970675
28MP0004134_abnormal_chest_morphology1.67799727
29MP0005410_abnormal_fertilization1.63211583
30MP0008789_abnormal_olfactory_epithelium1.62423456
31MP0002229_neurodegeneration1.61949287
32MP0000383_abnormal_hair_follicle1.61390612
33MP0006292_abnormal_olfactory_placode1.60167391
34MP0004859_abnormal_synaptic_plasticity1.60090317
35MP0008438_abnormal_cutaneous_collagen1.58488968
36MP0001299_abnormal_eye_distance/1.57722463
37MP0002734_abnormal_mechanical_nocicepti1.54977130
38MP0006276_abnormal_autonomic_nervous1.52629031
39MP0000955_abnormal_spinal_cord1.50146222
40MP0003937_abnormal_limbs/digits/tail_de1.49611950
41MP0010678_abnormal_skin_adnexa1.49158185
42MP0006054_spinal_hemorrhage1.44174853
43MP0009046_muscle_twitch1.42984580
44MP0002882_abnormal_neuron_morphology1.42153080
45MP0001293_anophthalmia1.41235576
46MP0005551_abnormal_eye_electrophysiolog1.41148294
47MP0005499_abnormal_olfactory_system1.39377881
48MP0005394_taste/olfaction_phenotype1.39377881
49MP0005423_abnormal_somatic_nervous1.38656186
50MP0004272_abnormal_basement_membrane1.37665066
51MP0003938_abnormal_ear_development1.36661915
52MP0003635_abnormal_synaptic_transmissio1.34830873
53MP0009745_abnormal_behavioral_response1.31400561
54MP0000534_abnormal_ureter_morphology1.31132814
55MP0003279_aneurysm1.30915876
56MP0002752_abnormal_somatic_nervous1.29559161
57MP0005187_abnormal_penis_morphology1.28675816
58MP0009780_abnormal_chondrocyte_physiolo1.28524534
59MP0002102_abnormal_ear_morphology1.27361962
60MP0004084_abnormal_cardiac_muscle1.24297706
61MP0003942_abnormal_urinary_system1.23671835
62MP0009053_abnormal_anal_canal1.23595577
63MP0001963_abnormal_hearing_physiology1.22736205
64MP0004381_abnormal_hair_follicle1.21677642
65MP0004133_heterotaxia1.21677196
66MP0001346_abnormal_lacrimal_gland1.20725407
67MP0002938_white_spotting1.20578248
68MP0003119_abnormal_digestive_system1.19067492
69MP0000428_abnormal_craniofacial_morphol1.18766928
70MP0000747_muscle_weakness1.16042521
71MP0002572_abnormal_emotion/affect_behav1.15804497
72MP0003283_abnormal_digestive_organ1.15331325
73MP0002066_abnormal_motor_capabilities/c1.14661120
74MP0004145_abnormal_muscle_electrophysio1.14107701
75MP0009250_abnormal_appendicular_skeleto1.12950710
76MP0001661_extended_life_span1.12182757
77MP0003631_nervous_system_phenotype1.12178548
78MP0004043_abnormal_pH_regulation1.11742342
79MP0000762_abnormal_tongue_morphology1.11394863
80MP0000751_myopathy1.11310039
81MP0002697_abnormal_eye_size1.10431567
82MP0003705_abnormal_hypodermis_morpholog1.09878816
83MP0001440_abnormal_grooming_behavior1.09037590
84MP0005275_abnormal_skin_tensile1.07730629
85MP0003121_genomic_imprinting1.06950321
86MP0002067_abnormal_sensory_capabilities1.06197790
87MP0002736_abnormal_nociception_after1.06150484
88MP0005195_abnormal_posterior_eye1.04958474
89MP0002751_abnormal_autonomic_nervous1.04886165
90MP0009379_abnormal_foot_pigmentation1.04780524
91MP0004147_increased_porphyrin_level1.04380972
92MP0000026_abnormal_inner_ear1.04358420
93MP0005451_abnormal_body_composition1.04247949
94MP0000647_abnormal_sebaceous_gland1.03916583
95MP0003935_abnormal_craniofacial_develop1.03450384
96MP0001286_abnormal_eye_development1.00890184
97MP0004215_abnormal_myocardial_fiber1.00666531
98MP0005248_abnormal_Harderian_gland1.00375774
99MP0002152_abnormal_brain_morphology0.99069950
100MP0001958_emphysema0.98973163
101MP0002234_abnormal_pharynx_morphology0.98599050
102MP0005253_abnormal_eye_physiology0.98559134
103MP0006072_abnormal_retinal_apoptosis0.98258903
104MP0002063_abnormal_learning/memory/cond0.97733105
105MP0000767_abnormal_smooth_muscle0.97330119
106MP0008569_lethality_at_weaning0.96529254
107MP0005386_behavior/neurological_phenoty0.96444063
108MP0004924_abnormal_behavior0.96444063
109MP0005508_abnormal_skeleton_morphology0.95001897
110MP0005595_abnormal_vascular_smooth0.93403932
111MP0000537_abnormal_urethra_morphology0.93294356
112MP0002822_catalepsy0.93000928
113MP0008260_abnormal_autophagy0.90948126
114MP0001984_abnormal_olfaction0.90837408
115MP0004811_abnormal_neuron_physiology0.90396940
116MP0002295_abnormal_pulmonary_circulatio0.89988200
117MP0005257_abnormal_intraocular_pressure0.89958352
118MP0002116_abnormal_craniofacial_bone0.89313817
119MP0001177_atelectasis0.87547149
120MP0002249_abnormal_larynx_morphology0.87319079
121MP0003861_abnormal_nervous_system0.86511474
122MP0000604_amyloidosis0.85474590
123MP0001970_abnormal_pain_threshold0.85465355
124MP0003385_abnormal_body_wall0.84485058
125MP0002932_abnormal_joint_morphology0.84140728
126MP0000631_abnormal_neuroendocrine_gland0.83798578
127MP0002108_abnormal_muscle_morphology0.81608292
128MP0003122_maternal_imprinting0.81420413
129MP0002081_perinatal_lethality0.81029358
130MP0003633_abnormal_nervous_system0.79087238
131MP0010030_abnormal_orbit_morphology0.77398734
132MP0003137_abnormal_impulse_conducting0.74988338
133MP0009384_cardiac_valve_regurgitation0.74380727
134MP0004036_abnormal_muscle_relaxation0.74098493
135MP0000749_muscle_degeneration0.73853237
136MP0002653_abnormal_ependyma_morphology0.73385050
137MP0002733_abnormal_thermal_nociception0.73159283
138MP0002184_abnormal_innervation0.72715921
139MP0003755_abnormal_palate_morphology0.72234025
140MP0005503_abnormal_tendon_morphology0.70220846
141MP0001340_abnormal_eyelid_morphology0.70011330
142MP0002233_abnormal_nose_morphology0.68536895
143MP0000372_irregular_coat_pigmentation0.67083917
144MP0005408_hypopigmentation0.67062625
145MP0002557_abnormal_social/conspecific_i0.65803976
146MP0005391_vision/eye_phenotype0.65509013

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.37425129
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.37425129
3Neurofibrillary tangles (HP:0002185)5.46874595
4Sensory axonal neuropathy (HP:0003390)4.87255856
5Abnormality of the corticospinal tract (HP:0002492)4.63058276
6Parakeratosis (HP:0001036)4.26380995
7Peripheral hypomyelination (HP:0007182)4.06413591
8Cerebral inclusion bodies (HP:0100314)3.78463246
9Cerebral hypomyelination (HP:0006808)3.76909095
10Termporal pattern (HP:0011008)3.44498214
11Insidious onset (HP:0003587)3.44498214
12Abnormal auditory evoked potentials (HP:0006958)3.37343688
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.31859602
14Alacrima (HP:0000522)3.31759432
15Onion bulb formation (HP:0003383)3.30669222
16Spastic gait (HP:0002064)3.17309933
17Increased serum pyruvate (HP:0003542)3.09435493
18Abnormality of glycolysis (HP:0004366)3.09435493
19Hypoplastic pelvis (HP:0008839)3.03015599
20Supranuclear gaze palsy (HP:0000605)3.00580060
21Akinesia (HP:0002304)2.89813242
22Intention tremor (HP:0002080)2.82136493
23Absent septum pellucidum (HP:0001331)2.80649912
24Premature skin wrinkling (HP:0100678)2.79537893
25Retinal dysplasia (HP:0007973)2.74768061
26Anteriorly placed anus (HP:0001545)2.74176127
27Decreased lacrimation (HP:0000633)2.72147540
28Leukodystrophy (HP:0002415)2.62845733
29Dysmetria (HP:0001310)2.60511515
30Thickened helices (HP:0000391)2.59948689
31Broad metatarsal (HP:0001783)2.56962090
32Shallow orbits (HP:0000586)2.56153905
33Coronal craniosynostosis (HP:0004440)2.54445812
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.53801192
35Short 4th metacarpal (HP:0010044)2.53801192
36Aplasia involving bones of the extremities (HP:0009825)2.49558754
37Aplasia involving bones of the upper limbs (HP:0009823)2.49558754
38Aplasia of the phalanges of the hand (HP:0009802)2.49558754
39Autoamputation (HP:0001218)2.49017637
40Protrusio acetabuli (HP:0003179)2.47248255
41Abnormality of the septum pellucidum (HP:0007375)2.46088499
42Type 2 muscle fiber atrophy (HP:0003554)2.42644341
43Ankle clonus (HP:0011448)2.38807730
44Adrenal hypoplasia (HP:0000835)2.37476783
45Premature rupture of membranes (HP:0001788)2.34239440
46Popliteal pterygium (HP:0009756)2.34087777
47Morphological abnormality of the inner ear (HP:0011390)2.33814739
48Scanning speech (HP:0002168)2.30334511
49Aortic aneurysm (HP:0004942)2.30229287
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.30190661
51Congenital ichthyosiform erythroderma (HP:0007431)2.29926478
52Stridor (HP:0010307)2.27940275
53Infantile muscular hypotonia (HP:0008947)2.27809654
54Thin ribs (HP:0000883)2.27282620
55Segmental peripheral demyelination/remyelination (HP:0003481)2.26260503
56Humeroradial synostosis (HP:0003041)2.26015877
57Synostosis involving the elbow (HP:0003938)2.26015877
58Megalencephaly (HP:0001355)2.24897736
59White forelock (HP:0002211)2.24457856
60Optic nerve hypoplasia (HP:0000609)2.23103607
61Esophageal atresia (HP:0002032)2.23075540
62Aortic dissection (HP:0002647)2.20988018
63Split foot (HP:0001839)2.19482202
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19432796
65Patchy hypopigmentation of hair (HP:0011365)2.19061572
66CNS hypomyelination (HP:0003429)2.18775873
67Spastic paraparesis (HP:0002313)2.18196323
68Vaginal atresia (HP:0000148)2.17856545
69Septo-optic dysplasia (HP:0100842)2.16403916
70Abnormality of the 4th metacarpal (HP:0010012)2.16335808
71Lower limb muscle weakness (HP:0007340)2.15357635
72Pheochromocytoma (HP:0002666)2.13080004
73Vitreoretinal degeneration (HP:0000655)2.12113572
74Cutaneous finger syndactyly (HP:0010554)2.11696545
75Increased circulating renin level (HP:0000848)2.11083443
76Cupped ear (HP:0000378)2.10209387
77Slow saccadic eye movements (HP:0000514)2.07854104
78Partial duplication of thumb phalanx (HP:0009944)2.07644247
79Genital tract atresia (HP:0001827)2.07402147
80Hypoplasia of the iris (HP:0007676)2.06338016
81Myelomeningocele (HP:0002475)2.05071988
82Cutaneous syndactyly (HP:0012725)2.04268413
83Abnormality of the ischium (HP:0003174)2.04057817
84Vascular tortuosity (HP:0004948)2.03332235
85Muscle fiber atrophy (HP:0100295)2.01202730
86Anomalous pulmonary venous return (HP:0010772)2.00817966
87Clumsiness (HP:0002312)1.99487811
88Abnormality of the labia minora (HP:0012880)1.99077202
89Arterial tortuosity (HP:0005116)1.97795393
90Muscle fiber splitting (HP:0003555)1.97741757
91Anophthalmia (HP:0000528)1.95310808
92Partial agenesis of the corpus callosum (HP:0001338)1.94474924
93Soft skin (HP:0000977)1.94321764
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92943797
95Decreased muscle mass (HP:0003199)1.92512134
96Hypomagnesemia (HP:0002917)1.92487920
97Bell-shaped thorax (HP:0001591)1.92396946
98Abnormality of the middle phalanges of the toes (HP:0010183)1.92019844
99Myokymia (HP:0002411)1.91820682
100Abnormality of the diencephalon (HP:0010662)1.91579014
101Cerebral hemorrhage (HP:0001342)1.89798928
102Steppage gait (HP:0003376)1.89654661
103Foot dorsiflexor weakness (HP:0009027)1.89472402
104Partial duplication of the phalanx of hand (HP:0009999)1.88046162
105Limited hip movement (HP:0008800)1.87084389
106Intestinal atresia (HP:0011100)1.85899959
107Neonatal short-limb short stature (HP:0008921)1.85779479
108Turricephaly (HP:0000262)1.84542609
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81387762
110Chin dimple (HP:0010751)1.80718127
111Gowers sign (HP:0003391)1.80274378
112Neuroendocrine neoplasm (HP:0100634)1.78613790
113Hypoventilation (HP:0002791)1.78336046
114Aplasia of the musculature (HP:0100854)1.77888770
115Wrist flexion contracture (HP:0001239)1.76373585
116Pterygium (HP:0001059)1.76277974
117Decreased motor nerve conduction velocity (HP:0003431)1.76261744
118Wide anterior fontanel (HP:0000260)1.75987603
119Abnormality of the foot musculature (HP:0001436)1.75867917
120Calcaneovalgus deformity (HP:0001848)1.75815537
121Rib fusion (HP:0000902)1.75626943
122Deformed tarsal bones (HP:0008119)1.74880800
123Preaxial foot polydactyly (HP:0001841)1.74704614
124Hammertoe (HP:0001765)1.74043703
125Hypoplastic ischia (HP:0003175)1.73607915
126Abnormality of the pulmonary veins (HP:0011718)1.73210822
127Broad long bones (HP:0005622)1.72158401
128Methylmalonic acidemia (HP:0002912)1.71789692
129Absent/shortened dynein arms (HP:0200106)1.71717822
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.71717822
131Gait imbalance (HP:0002141)1.70073592
132Fetal akinesia sequence (HP:0001989)1.70010706
133Bowel incontinence (HP:0002607)1.69969629
134Relative macrocephaly (HP:0004482)1.69441337
135Metabolic alkalosis (HP:0200114)1.69423339
136Prominent occiput (HP:0000269)1.68837314
137Stenosis of the external auditory canal (HP:0000402)1.68083763
138Gastrointestinal atresia (HP:0002589)1.67809915
139Bladder diverticulum (HP:0000015)1.67605820
140Abnormality of dentin (HP:0010299)1.66724793
141Poor speech (HP:0002465)1.66468008
142Mixed hearing impairment (HP:0000410)1.66082346
143Weak cry (HP:0001612)1.65042601
144Hepatosplenomegaly (HP:0001433)1.64365866
145Bowel diverticulosis (HP:0005222)1.63797690
146Anterior segment dysgenesis (HP:0007700)1.63513008
147Abolished electroretinogram (ERG) (HP:0000550)1.62661529
148Broad phalanx (HP:0006009)1.61942759
149Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.61617341
150Enlarged penis (HP:0000040)1.60724195
151Ankle contracture (HP:0006466)1.60605065
152Supernumerary spleens (HP:0009799)1.60414289
153Mesomelia (HP:0003027)1.60213452
154Occipital encephalocele (HP:0002085)1.59666849
155Amniotic constriction ring (HP:0009775)1.59264954
156Abnormality of placental membranes (HP:0011409)1.59264954
157Congenital primary aphakia (HP:0007707)1.59094093
158Narrow nasal bridge (HP:0000446)1.58402056
159Medial flaring of the eyebrow (HP:0010747)1.57812248
160Keratoconus (HP:0000563)1.57647421
161Increased corneal curvature (HP:0100692)1.57647421
162Colon cancer (HP:0003003)1.57249417
163Hepatoblastoma (HP:0002884)1.55730692
164Hip contracture (HP:0003273)1.55441936
165Pancreatic fibrosis (HP:0100732)1.54435255
166Action tremor (HP:0002345)1.54122811
167Bifid tongue (HP:0010297)1.54117735
168Postaxial hand polydactyly (HP:0001162)1.51713725
169Focal seizures (HP:0007359)1.51579987
170Broad finger (HP:0001500)1.50188280
171Hemiparesis (HP:0001269)1.48285390
172Pulmonary artery stenosis (HP:0004415)1.48029404
173Atonic seizures (HP:0010819)1.47987294
174Fibular hypoplasia (HP:0003038)1.47549640
175True hermaphroditism (HP:0010459)1.46612554
176Broad thumb (HP:0011304)1.45852246
177Renal hypoplasia (HP:0000089)1.44559568
178Limb-girdle muscle weakness (HP:0003325)1.44294901
179Abnormal number of incisors (HP:0011064)1.43631073
180Cystic hygroma (HP:0000476)1.43561697
181Broad phalanges of the hand (HP:0009768)1.43308755
182Hypoplasia of the ulna (HP:0003022)1.42284279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.45338808
2TIE14.62007954
3OXSR14.45146148
4BCR3.12148056
5EPHB13.04183185
6PRPF4B2.96729742
7TNIK2.77803266
8WNK42.67199289
9PBK2.66887228
10INSRR2.44640351
11PKN12.36547912
12MET2.32422210
13FGFR22.18973172
14CDK192.18676874
15LIMK12.07246214
16WNK12.04995740
17UHMK11.98463590
18ICK1.90002540
19NEK61.88408381
20MAPKAPK51.84527908
21CSNK1G31.72351512
22KDR1.70260042
23PNCK1.70126740
24CSNK1A1L1.63745594
25ROCK21.62181107
26NTRK11.48033602
27TYRO31.44392372
28CASK1.43629592
29PAK61.41201117
30CSNK1G11.36157531
31MINK11.34813293
32MUSK1.33381074
33CLK11.33190938
34PLK31.32990981
35CAMK2B1.31669924
36NTRK31.30229821
37MYLK1.30065568
38WEE11.27487975
39MAP3K41.25583615
40FGR1.23998679
41EPHA41.22973174
42CSNK1G21.22398747
43MKNK21.16743511
44CAMK2D1.15818204
45CCNB11.12528413
46TESK21.11644827
47PAK31.07483202
48MARK11.05588274
49DYRK21.03949401
50PDGFRA0.98273896
51BMPR1B0.98266783
52MST40.97220040
53CDC70.97060312
54LATS20.96814669
55SGK2230.95751434
56SGK4940.95751434
57PRKCG0.94824997
58CDK140.92956366
59PLK40.90476668
60BRSK10.90056573
61MAPK150.90023738
62PTK20.81468468
63MAP2K70.80276254
64CDK150.79038685
65GRK50.78849517
66CAMK2G0.77840862
67BRSK20.77485857
68CDK180.76289751
69MKNK10.73303765
70VRK10.73155635
71IRAK20.72314855
72KSR10.71934382
73PRKCQ0.71861038
74PHKG20.71748750
75PHKG10.71748750
76STK30.71738165
77CAMK2A0.71342146
78ERBB40.71316047
79SRPK10.71172559
80CDK11A0.71025426
81SGK20.69447185
82DYRK30.68790181
83MAPK130.68531395
84MARK20.68413874
85TGFBR10.68138475
86CDK50.67587539
87PINK10.66994856
88STK38L0.66134069
89NTRK20.64266411
90CAMK1G0.63267352
91PLK10.60929305
92MAP4K20.60461804
93TAF10.60050857
94FGFR10.59324544
95ERBB20.57646935
96PRKCE0.55918403
97MELK0.55549237
98PRKD10.54890811
99ZAK0.54881855
100FER0.54630326
101DDR20.54193945
102NUAK10.51880716
103CAMK10.51271848
104RPS6KA50.50890517
105DAPK30.49943620
106DYRK1B0.49438914
107CSNK1D0.48548153
108ILK0.48260597
109BMX0.48011886
110CDK80.47391659
111ROCK10.46832411
112FYN0.46746197
113LATS10.45849005
114PRKG10.44417293
115ARAF0.40854736
116CSNK1A10.39251117
117PRKACB0.39090630
118GSK3A0.38719727
119PAK10.38544232
120MOS0.38489007
121OBSCN0.37432498
122MAPK70.37179191
123EPHB20.37141102
124PDGFRB0.36194373
125WNK30.36162430
126IRAK10.35209919
127TRPM70.34027154
128PTK2B0.32521792
129STK160.31301220
130PDPK10.29530546
131INSR0.29373160
132MAP3K130.29359970
133PRKACA0.26337809
134DYRK1A0.26077872
135PRKD30.25755800
136DMPK0.25490583
137ADRBK20.25167372
138PAK20.24482129
139PRKCH0.23509544
140MAPK100.22930015
141GRK10.22220911
142STK110.22145787
143CSNK1E0.21436638
144KSR20.20848337
145PIK3CA0.20785231
146PLK20.20699924

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.71975760
2Steroid biosynthesis_Homo sapiens_hsa001005.02446530
3Fatty acid elongation_Homo sapiens_hsa000624.34450170
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.86513727
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.50752951
6Ether lipid metabolism_Homo sapiens_hsa005653.17661926
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42072587
8Axon guidance_Homo sapiens_hsa043602.23534888
9Protein export_Homo sapiens_hsa030601.96207635
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.93932336
11Oxidative phosphorylation_Homo sapiens_hsa001901.90210327
12Sphingolipid metabolism_Homo sapiens_hsa006001.86192794
13Vitamin B6 metabolism_Homo sapiens_hsa007501.80204989
14Sulfur metabolism_Homo sapiens_hsa009201.74228847
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72910043
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58669737
17Linoleic acid metabolism_Homo sapiens_hsa005911.55874764
18Adherens junction_Homo sapiens_hsa045201.45158507
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43473639
20TGF-beta signaling pathway_Homo sapiens_hsa043501.36218140
21Serotonergic synapse_Homo sapiens_hsa047261.35219967
22Parkinsons disease_Homo sapiens_hsa050121.33942322
23* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33126624
24Butanoate metabolism_Homo sapiens_hsa006501.28014217
25Alzheimers disease_Homo sapiens_hsa050101.25325338
26Rap1 signaling pathway_Homo sapiens_hsa040151.23804944
27Renal cell carcinoma_Homo sapiens_hsa052111.23614742
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22549826
29Glutamatergic synapse_Homo sapiens_hsa047241.22108823
30GABAergic synapse_Homo sapiens_hsa047271.20991880
31Arginine and proline metabolism_Homo sapiens_hsa003301.17366177
32Insulin secretion_Homo sapiens_hsa049111.14785844
33Long-term depression_Homo sapiens_hsa047301.09902750
34Hedgehog signaling pathway_Homo sapiens_hsa043401.09212989
35* Tight junction_Homo sapiens_hsa045301.09171034
36Fanconi anemia pathway_Homo sapiens_hsa034601.08670350
37Mismatch repair_Homo sapiens_hsa034301.07520308
38Notch signaling pathway_Homo sapiens_hsa043301.03639698
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02639401
40Histidine metabolism_Homo sapiens_hsa003401.01740725
41Vibrio cholerae infection_Homo sapiens_hsa051101.01480088
42Protein digestion and absorption_Homo sapiens_hsa049741.00162483
43Melanoma_Homo sapiens_hsa052180.99949878
44Arachidonic acid metabolism_Homo sapiens_hsa005900.93108194
45Morphine addiction_Homo sapiens_hsa050320.92687638
46Oocyte meiosis_Homo sapiens_hsa041140.92342521
47Amphetamine addiction_Homo sapiens_hsa050310.90996372
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89515912
49Cell cycle_Homo sapiens_hsa041100.88881240
50ECM-receptor interaction_Homo sapiens_hsa045120.85949692
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85866901
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.84748888
53Pathways in cancer_Homo sapiens_hsa052000.82963957
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82565177
55Glutathione metabolism_Homo sapiens_hsa004800.82206895
56Ras signaling pathway_Homo sapiens_hsa040140.81673531
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80960009
58Collecting duct acid secretion_Homo sapiens_hsa049660.80646688
59Oxytocin signaling pathway_Homo sapiens_hsa049210.79930433
60Ovarian steroidogenesis_Homo sapiens_hsa049130.79924744
61MicroRNAs in cancer_Homo sapiens_hsa052060.79729275
62Nitrogen metabolism_Homo sapiens_hsa009100.79587567
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.79122168
64Cardiac muscle contraction_Homo sapiens_hsa042600.78301542
65Calcium signaling pathway_Homo sapiens_hsa040200.77952580
66Huntingtons disease_Homo sapiens_hsa050160.77477263
67Dorso-ventral axis formation_Homo sapiens_hsa043200.76215168
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75979413
69Fatty acid metabolism_Homo sapiens_hsa012120.74945276
70Proteoglycans in cancer_Homo sapiens_hsa052050.74174590
71Basal cell carcinoma_Homo sapiens_hsa052170.73547133
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.72898843
73Phototransduction_Homo sapiens_hsa047440.72280821
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72253227
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72148479
76Cocaine addiction_Homo sapiens_hsa050300.71706247
77Endocytosis_Homo sapiens_hsa041440.69823327
78Homologous recombination_Homo sapiens_hsa034400.68157083
79Circadian entrainment_Homo sapiens_hsa047130.67528155
80Olfactory transduction_Homo sapiens_hsa047400.64566422
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63146787
82ErbB signaling pathway_Homo sapiens_hsa040120.62625412
83Thyroid hormone synthesis_Homo sapiens_hsa049180.59788489
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59598863
85Basal transcription factors_Homo sapiens_hsa030220.59541068
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58800603
87Gap junction_Homo sapiens_hsa045400.58677163
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57564532
89Cholinergic synapse_Homo sapiens_hsa047250.56945059
90Hippo signaling pathway_Homo sapiens_hsa043900.56539192
91Rheumatoid arthritis_Homo sapiens_hsa053230.56504640
92Colorectal cancer_Homo sapiens_hsa052100.56232780
93Autoimmune thyroid disease_Homo sapiens_hsa053200.55901636
94Long-term potentiation_Homo sapiens_hsa047200.55556180
95Dopaminergic synapse_Homo sapiens_hsa047280.54901454
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54792673
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53536610
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53144891
99Wnt signaling pathway_Homo sapiens_hsa043100.53060087
100Glioma_Homo sapiens_hsa052140.51637037
101Nicotine addiction_Homo sapiens_hsa050330.51252474
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51091157
103Salivary secretion_Homo sapiens_hsa049700.51034890
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.49968130
105RNA polymerase_Homo sapiens_hsa030200.48871927
106Nucleotide excision repair_Homo sapiens_hsa034200.48348529
107Propanoate metabolism_Homo sapiens_hsa006400.47929011
108Platelet activation_Homo sapiens_hsa046110.47903312
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47575601
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46245792
111Alcoholism_Homo sapiens_hsa050340.45998771
112beta-Alanine metabolism_Homo sapiens_hsa004100.45711506
113Small cell lung cancer_Homo sapiens_hsa052220.45201883
114Folate biosynthesis_Homo sapiens_hsa007900.44139258
115Mineral absorption_Homo sapiens_hsa049780.43904526
116Malaria_Homo sapiens_hsa051440.42946805
117Fatty acid biosynthesis_Homo sapiens_hsa000610.42529084
118p53 signaling pathway_Homo sapiens_hsa041150.41866996
119Lysosome_Homo sapiens_hsa041420.40809499
120Gastric acid secretion_Homo sapiens_hsa049710.40415253
121Choline metabolism in cancer_Homo sapiens_hsa052310.39551761
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39300860
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39180686
124Metabolic pathways_Homo sapiens_hsa011000.38907343
125Melanogenesis_Homo sapiens_hsa049160.36650927
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36117696
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35512388
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.34682708
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33827707
130* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33745733
131Phagosome_Homo sapiens_hsa041450.32848089
132Pancreatic secretion_Homo sapiens_hsa049720.32810167
133Renin secretion_Homo sapiens_hsa049240.31772412
134Dilated cardiomyopathy_Homo sapiens_hsa054140.30861991
135Taste transduction_Homo sapiens_hsa047420.30796788
136Focal adhesion_Homo sapiens_hsa045100.28745870
137cAMP signaling pathway_Homo sapiens_hsa040240.28417690
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26694419
139Prion diseases_Homo sapiens_hsa050200.25781681
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25707854
141Synaptic vesicle cycle_Homo sapiens_hsa047210.25378464

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