JAML

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.15473308
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.15473308
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.73352270
4positive regulation of gamma-delta T cell activation (GO:0046645)6.25552478
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.69360139
6antigen processing and presentation of endogenous antigen (GO:0019883)5.62911326
7positive regulation by symbiont of host defense response (GO:0052509)5.53332855
8modulation by symbiont of host defense response (GO:0052031)5.53332855
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53332855
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53332855
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.53332855
12modulation by symbiont of host immune response (GO:0052553)5.53332855
13regulation of B cell receptor signaling pathway (GO:0050855)5.49323760
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.08522348
15neutrophil activation involved in immune response (GO:0002283)5.04239352
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.92826188
17response to interleukin-15 (GO:0070672)4.88342880
18detection of other organism (GO:0098543)4.87262963
19cellular response to interleukin-15 (GO:0071350)4.73818233
20macrophage activation involved in immune response (GO:0002281)4.64334552
21regulation of gamma-delta T cell activation (GO:0046643)4.64188501
22detection of bacterium (GO:0016045)4.59552461
23negative regulation of lymphocyte mediated immunity (GO:0002707)4.57611024
24leukocyte aggregation (GO:0070486)4.51026651
25detection of molecule of bacterial origin (GO:0032490)4.44953308
26regulation of gamma-delta T cell differentiation (GO:0045586)4.38490742
27detection of external biotic stimulus (GO:0098581)4.36306529
28cellular extravasation (GO:0045123)4.18374077
29negative regulation of T cell mediated immunity (GO:0002710)4.18351419
30neutrophil activation (GO:0042119)4.17467429
31negative regulation of interleukin-12 production (GO:0032695)4.17299404
32microglial cell activation (GO:0001774)4.12910802
33response to peptidoglycan (GO:0032494)4.12510463
34negative regulation of leukocyte mediated immunity (GO:0002704)3.98877863
35negative T cell selection (GO:0043383)3.98490460
36regulation of interferon-beta biosynthetic process (GO:0045357)3.98340145
37respiratory burst (GO:0045730)3.97370881
38negative thymic T cell selection (GO:0045060)3.91170308
39positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.89957077
40immunoglobulin mediated immune response (GO:0016064)3.87929607
41antigen processing and presentation via MHC class Ib (GO:0002475)3.86920824
42detection of biotic stimulus (GO:0009595)3.84568482
43response to host immune response (GO:0052572)3.82392722
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.82392722
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.82086428
46granulocyte activation (GO:0036230)3.77907119
47myeloid cell activation involved in immune response (GO:0002275)3.73037568
48positive thymic T cell selection (GO:0045059)3.71528236
49neutrophil mediated immunity (GO:0002446)3.71371931
50leukocyte migration involved in inflammatory response (GO:0002523)3.69420694
51macrophage activation (GO:0042116)3.63281551
52B cell receptor signaling pathway (GO:0050853)3.61174814
53regulation of T cell mediated cytotoxicity (GO:0001914)3.53341438
54regulation of mast cell degranulation (GO:0043304)3.49261407
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.49207316
56response to host (GO:0075136)3.49207316
57response to host defenses (GO:0052200)3.49207316
58regulation of B cell differentiation (GO:0045577)3.48925688
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48224947
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.46309589
61positive regulation of mast cell activation (GO:0033005)3.44238306
62positive T cell selection (GO:0043368)3.43200270
63regulation of T cell tolerance induction (GO:0002664)3.40323959
64leukocyte degranulation (GO:0043299)3.39380990
65positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39308042
66regulation of alpha-beta T cell proliferation (GO:0046640)3.37106083
67regulation of tolerance induction (GO:0002643)3.35849350
68regulation of regulatory T cell differentiation (GO:0045589)3.34856084
69production of molecular mediator involved in inflammatory response (GO:0002532)3.34150595
70cellular response to type I interferon (GO:0071357)3.31643182
71type I interferon signaling pathway (GO:0060337)3.31643182
72activated T cell proliferation (GO:0050798)3.30932369
73response to type I interferon (GO:0034340)3.29215460
74negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.25593829
75negative regulation of T-helper cell differentiation (GO:0045623)3.25593829
76myeloid leukocyte mediated immunity (GO:0002444)3.24066320
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23540340
78negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.23304106
79regulation of mast cell activation involved in immune response (GO:0033006)3.21290122
80positive regulation of B cell differentiation (GO:0045579)3.20871774
81regulation of mast cell activation (GO:0033003)3.20599067
82regulation of natural killer cell mediated immunity (GO:0002715)3.18987687
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.18987687
84T cell selection (GO:0045058)3.18964218
85T cell migration (GO:0072678)3.15322028
86response to muramyl dipeptide (GO:0032495)3.14112340
87interferon-gamma-mediated signaling pathway (GO:0060333)3.13837493
88dendritic cell migration (GO:0036336)3.13753266
89B cell mediated immunity (GO:0019724)3.12357268
90defense response to protozoan (GO:0042832)3.12277597
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11145442
92dendritic cell chemotaxis (GO:0002407)3.06643964
93mast cell activation (GO:0045576)3.05422562
94tolerance induction (GO:0002507)3.05342467
95regulation of leukocyte degranulation (GO:0043300)3.03509281
96negative regulation of adaptive immune response (GO:0002820)3.02231960
97negative regulation of innate immune response (GO:0045824)2.98872282
98regulation of leukocyte mediated cytotoxicity (GO:0001910)2.96774353
99thymic T cell selection (GO:0045061)2.94192302
100positive regulation of tolerance induction (GO:0002645)2.92229560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.05640797
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.79978269
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.65958790
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.50674209
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.39575018
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78337372
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.30465271
8RUNX_20019798_ChIP-Seq_JUKART_Human3.24124420
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.23582927
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.18339540
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11502944
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.95140311
13SPI1_23547873_ChIP-Seq_NB4_Human2.82160040
14MYB_26560356_Chip-Seq_TH2_Human2.74223064
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71649928
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69184610
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.62154821
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53773228
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53648638
20SPI1_23127762_ChIP-Seq_K562_Human2.50655806
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42065106
22SCL_19346495_ChIP-Seq_HPC-7_Human2.38960953
23MAF_26560356_Chip-Seq_TH1_Human2.38351565
24VDR_24763502_ChIP-Seq_THP-1_Human2.34698378
25MYB_26560356_Chip-Seq_TH1_Human2.22980134
26VDR_21846776_ChIP-Seq_THP-1_Human2.20541723
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.18514357
28UTX_26944678_Chip-Seq_JUKART_Human2.16108316
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14959012
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08241490
31GATA3_27048872_Chip-Seq_THYMUS_Human2.00486485
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.92102368
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87600074
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86448858
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85455457
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84733194
37MYC_22102868_ChIP-Seq_BL_Human1.81093337
38MAF_26560356_Chip-Seq_TH2_Human1.75784552
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72981481
40VDR_24787735_ChIP-Seq_THP-1_Human1.72322483
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63502403
42GATA3_26560356_Chip-Seq_TH2_Human1.63247226
43TCF7_22412390_ChIP-Seq_EML_Mouse1.63026317
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61210132
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59740364
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55909864
47GATA1_22025678_ChIP-Seq_K562_Human1.52804254
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52179097
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48709356
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48362103
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.48344121
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45912201
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41472310
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39346881
55KDM2B_26808549_Chip-Seq_DND41_Human1.39098272
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37992855
57PU_27001747_Chip-Seq_BMDM_Mouse1.37005377
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.34715168
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34100138
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29275881
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29185242
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29025716
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28186365
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26826999
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26327772
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24279076
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23363066
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21320747
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20098022
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17335776
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16843140
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13511550
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13265345
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11938649
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11741590
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11341040
77GATA1_19941826_ChIP-Seq_K562_Human1.10696852
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07365558
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06204284
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.04598519
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01717122
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00960335
83BCL6_27268052_Chip-Seq_Bcells_Human0.97467914
84KDM2B_26808549_Chip-Seq_JURKAT_Human0.95506773
85GATA2_19941826_ChIP-Seq_K562_Human0.93653761
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92835857
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90393219
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90158774
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.87164632
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85591859
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83994891
92BCOR_27268052_Chip-Seq_Bcells_Human0.82700260
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81294066
94SPI1_20517297_ChIP-Seq_HL60_Human0.81273566
95SMRT_27268052_Chip-Seq_Bcells_Human0.80880881
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77525505
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75802231
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.73756362
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73018838
100CIITA_25753668_ChIP-Seq_RAJI_Human0.71964683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.09137833
2MP0001835_abnormal_antigen_presentation4.12859001
3MP0003436_decreased_susceptibility_to4.08521949
4MP0005671_abnormal_response_to3.62198736
5MP0003303_peritoneal_inflammation3.17644972
6MP0002419_abnormal_innate_immunity3.11107286
7MP0001800_abnormal_humoral_immune3.10419982
8MP0009785_altered_susceptibility_to3.00410597
9MP0005000_abnormal_immune_tolerance2.97146038
10MP0000685_abnormal_immune_system2.93247565
11MP0005025_abnormal_response_to2.93222253
12MP0002723_abnormal_immune_serum2.75771530
13MP0005387_immune_system_phenotype2.75740270
14MP0001790_abnormal_immune_system2.75740270
15MP0002420_abnormal_adaptive_immunity2.67567640
16MP0003763_abnormal_thymus_physiology2.67322401
17MP0001819_abnormal_immune_cell2.64936549
18MP0002452_abnormal_antigen_presenting2.60891474
19MP0006082_CNS_inflammation2.53355235
20MP0002148_abnormal_hypersensitivity_rea2.35801073
21MP0003300_gastrointestinal_ulcer2.19971064
22MP0002405_respiratory_system_inflammati2.13666755
23MP0008260_abnormal_autophagy2.10809101
24MP0001533_abnormal_skeleton_physiology2.10181097
25MP0002398_abnormal_bone_marrow2.09215294
26MP0000716_abnormal_immune_system2.03409533
27MP0003191_abnormal_cellular_cholesterol2.00387333
28MP0005464_abnormal_platelet_physiology1.99855005
29MP0003866_abnormal_defecation1.91619718
30MP0010155_abnormal_intestine_physiology1.84959065
31MP0001845_abnormal_inflammatory_respons1.79393944
32MP0000689_abnormal_spleen_morphology1.74802634
33MP0004381_abnormal_hair_follicle1.74625106
34MP0002722_abnormal_immune_system1.73174237
35MP0004947_skin_inflammation1.71885405
36MP0003828_pulmonary_edema1.70764691
37MP0000465_gastrointestinal_hemorrhage1.69810026
38MP0003172_abnormal_lysosome_physiology1.67879427
39MP0002132_abnormal_respiratory_system1.66911968
40MP0009333_abnormal_splenocyte_physiolog1.65230146
41MP0000703_abnormal_thymus_morphology1.64872474
42MP0002429_abnormal_blood_cell1.59673178
43MP0002396_abnormal_hematopoietic_system1.59508368
44MP0002277_abnormal_respiratory_mucosa1.47329354
45MP0009764_decreased_sensitivity_to1.45748399
46MP0002166_altered_tumor_susceptibility1.44879222
47MP0003183_abnormal_peptide_metabolism1.44475282
48MP0008469_abnormal_protein_level1.42031940
49MP0004883_abnormal_blood_vessel1.41831946
50MP0005310_abnormal_salivary_gland1.40794539
51MP0000569_abnormal_digit_pigmentation1.38334061
52MP0005451_abnormal_body_composition1.37990327
53MP0000858_altered_metastatic_potential1.34593093
54MP0005075_abnormal_melanosome_morpholog1.31116890
55MP0009278_abnormal_bone_marrow1.29370947
56MP0001851_eye_inflammation1.25402595
57MP0002998_abnormal_bone_remodeling1.20073518
58MP0005164_abnormal_response_to1.06613348
59MP0003075_altered_response_to1.06125788
60MP0005397_hematopoietic_system_phenotyp1.04925459
61MP0001545_abnormal_hematopoietic_system1.04925459
62MP0003690_abnormal_glial_cell1.03155055
63MP0000015_abnormal_ear_pigmentation0.97427911
64MP0001853_heart_inflammation0.95361102
65MP0002006_tumorigenesis0.93164324
66MP0005166_decreased_susceptibility_to0.91819803
67MP0009763_increased_sensitivity_to0.90299584
68MP0003448_altered_tumor_morphology0.89892777
69MP0003656_abnormal_erythrocyte_physiolo0.85884739
70MP0005058_abnormal_lysosome_morphology0.83490215
71MP0001873_stomach_inflammation0.81655314
72MP0003045_fibrosis0.80417598
73MP0005390_skeleton_phenotype0.80302137
74MP0000604_amyloidosis0.80211083
75MP0004510_myositis0.78649491
76MP0001663_abnormal_digestive_system0.77481709
77MP0002933_joint_inflammation0.76992778
78MP0003806_abnormal_nucleotide_metabolis0.74946172
79MP0005174_abnormal_tail_pigmentation0.72590012
80MP0009765_abnormal_xenobiotic_induced0.71698066
81MP0001986_abnormal_taste_sensitivity0.71076583
82MP0000343_altered_response_to0.69474384
83MP0004808_abnormal_hematopoietic_stem0.68430600
84MP0004130_abnormal_muscle_cell0.65855608
85MP0000249_abnormal_blood_vessel0.64024887
86MP0003795_abnormal_bone_structure0.63930071
87MP0003221_abnormal_cardiomyocyte_apopto0.62991591
88MP0005377_hearing/vestibular/ear_phenot0.61152331
89MP0003878_abnormal_ear_physiology0.61152331
90MP0003787_abnormal_imprinting0.60304826
91MP0000490_abnormal_crypts_of0.58683213
92MP0003252_abnormal_bile_duct0.57599985
93MP0008004_abnormal_stomach_pH0.56790983
94MP0008874_decreased_physiological_sensi0.56009983
95MP0002019_abnormal_tumor_incidence0.55639072
96MP0005388_respiratory_system_phenotype0.51232877
97MP0002133_abnormal_respiratory_system0.51232877
98MP0005083_abnormal_biliary_tract0.51084196
99MP0002138_abnormal_hepatobiliary_system0.50275505
100MP0004484_altered_response_of0.50139417

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.73246562
2Recurrent bacterial skin infections (HP:0005406)6.08315472
3Recurrent abscess formation (HP:0002722)6.04534748
4Myositis (HP:0100614)6.01468814
5Orchitis (HP:0100796)5.75243209
6Retrobulbar optic neuritis (HP:0100654)5.62048527
7Optic neuritis (HP:0100653)5.62048527
8Stomatitis (HP:0010280)5.03140300
9Abnormality of macrophages (HP:0004311)5.00463551
10Elevated erythrocyte sedimentation rate (HP:0003565)4.90321153
11Recurrent gram-negative bacterial infections (HP:0005420)4.81623532
12Gastrointestinal infarctions (HP:0005244)4.66762046
13T lymphocytopenia (HP:0005403)4.64244963
14Recurrent fungal infections (HP:0002841)4.57536343
15Abnormality of T cell number (HP:0011839)4.37034597
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.14786887
17Obstructive lung disease (HP:0006536)4.12471107
18Chronic obstructive pulmonary disease (HP:0006510)4.12471107
19Mediastinal lymphadenopathy (HP:0100721)4.12362565
20Recurrent skin infections (HP:0001581)4.11702281
21Meningitis (HP:0001287)4.10260511
22Keratoconjunctivitis sicca (HP:0001097)4.08585229
23Recurrent cutaneous fungal infections (HP:0011370)3.92274753
24Chronic mucocutaneous candidiasis (HP:0002728)3.92274753
25Encephalitis (HP:0002383)3.91737630
26Keratoconjunctivitis (HP:0001096)3.82605629
27Vasculitis (HP:0002633)3.63225902
28Gingivitis (HP:0000230)3.63219995
29Spontaneous hematomas (HP:0007420)3.58821217
30Urticaria (HP:0001025)3.45181049
31Abnormality of T cells (HP:0002843)3.43235857
32Chest pain (HP:0100749)3.38054715
33Hemoptysis (HP:0002105)3.33370466
34Pulmonary infiltrates (HP:0002113)3.29795436
35Leukocytosis (HP:0001974)3.25440560
36Hypochromic microcytic anemia (HP:0004840)3.25083249
37Increased IgE level (HP:0003212)3.22332868
38Arterial thrombosis (HP:0004420)3.15527037
39Prolonged bleeding time (HP:0003010)3.07316225
40Gingival bleeding (HP:0000225)3.07040659
41Recurrent viral infections (HP:0004429)3.04454410
42Hypochromic anemia (HP:0001931)3.00197239
43Cellulitis (HP:0100658)2.92056882
44Anorexia (HP:0002039)2.91962536
45Peritonitis (HP:0002586)2.91799517
46Episodic fever (HP:0001954)2.90153253
47Pulmonary embolism (HP:0002204)2.89388441
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.87983712
49Panhypogammaglobulinemia (HP:0003139)2.84770989
50Pustule (HP:0200039)2.83860551
51Granulocytopenia (HP:0001913)2.79346163
52Epistaxis (HP:0000421)2.75988728
53Inflammation of the large intestine (HP:0002037)2.71847644
54Gangrene (HP:0100758)2.63562194
55Increased IgM level (HP:0003496)2.63464593
56Gastrointestinal inflammation (HP:0004386)2.58403136
57Abnormality of the pleura (HP:0002103)2.56689557
58Abnormality of eosinophils (HP:0001879)2.54037528
59Eosinophilia (HP:0001880)2.53725146
60Abnormality of T cell physiology (HP:0011840)2.50536493
61Osteomyelitis (HP:0002754)2.47121833
62Amyloidosis (HP:0011034)2.46481757
63Lymphopenia (HP:0001888)2.35051585
64Sepsis (HP:0100806)2.34776718
65Recurrent bronchitis (HP:0002837)2.34758781
66Petechiae (HP:0000967)2.34351157
67Microcytic anemia (HP:0001935)2.31467681
68Glomerulopathy (HP:0100820)2.27961538
69Severe combined immunodeficiency (HP:0004430)2.26223527
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.23017147
71Abnormality of the peritoneum (HP:0002585)2.22333610
72Acute hepatic failure (HP:0006554)2.21355289
73Abnormality of the endocardium (HP:0004306)2.20758577
74Keratitis (HP:0000491)2.19806462
75Vertigo (HP:0002321)2.17426674
76IgM deficiency (HP:0002850)2.17292855
77Hypergammaglobulinemia (HP:0010702)2.16110545
78IgG deficiency (HP:0004315)2.14951143
79Colitis (HP:0002583)2.13225508
80Agammaglobulinemia (HP:0004432)2.12923294
81Slow saccadic eye movements (HP:0000514)2.11825698
82Autoimmune hemolytic anemia (HP:0001890)2.09964952
83Skin ulcer (HP:0200042)2.06494068
84Joint swelling (HP:0001386)2.05826298
85Abnormality of the pericardium (HP:0001697)2.04510181
86Polyneuropathy (HP:0001271)2.03037261
87Acne (HP:0001061)1.98784932
88Hepatosplenomegaly (HP:0001433)1.96845940
89Chronic otitis media (HP:0000389)1.95679922
90Thrombophlebitis (HP:0004418)1.91656202
91Skin rash (HP:0000988)1.89046874
92Autoimmune thrombocytopenia (HP:0001973)1.87171423
93Premature loss of primary teeth (HP:0006323)1.86320271
94Purpura (HP:0000979)1.84748850
95Chronic diarrhea (HP:0002028)1.84439270
96Amaurosis fugax (HP:0100576)1.83345396
97Viral hepatitis (HP:0006562)1.83188326
98Recurrent pneumonia (HP:0006532)1.79744418
99Arthralgia (HP:0002829)1.79519313
100Increased cerebral lipofuscin (HP:0011813)1.79002456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.65070951
2MAP4K13.68642489
3BLK3.20186278
4TXK2.98287001
5IRAK42.96333449
6FES2.90723591
7CSK2.84232890
8GRK62.77540356
9TYK22.76850625
10MAP2K32.59014205
11TAOK32.41925641
12ERN12.12902439
13TNK22.06509343
14ZAP702.05223921
15JAK32.01740730
16MAP3K141.95029665
17BTK1.93780276
18EPHB11.87744727
19SYK1.86710234
20IKBKE1.85271872
21FGR1.84828074
22HCK1.76113374
23JAK11.71161349
24LYN1.49315487
25MAP3K31.48399848
26PRPF4B1.45178859
27MAP3K111.44704052
28TAOK11.42841016
29JAK21.41408410
30MAP3K131.39419974
31LCK1.38076260
32KIT1.37820846
33ITK1.37312852
34BMPR21.35291504
35TBK11.33157527
36CSF1R1.25954641
37MATK1.18872465
38MAP3K11.17634857
39YES11.15791306
40KSR21.13045780
41TEC1.10598154
42MARK31.03182873
43IKBKB1.03081154
44TESK21.00198760
45IRAK10.97753842
46SIK30.93988533
47STK100.88748533
48PDK10.88164189
49CDK190.86896689
50MARK20.85473420
51PTK60.81897785
52PIK3CG0.81258258
53FGFR30.76639663
54TGFBR20.76590742
55LRRK20.76038978
56MAP3K20.74859062
57FYN0.73807992
58PRKCQ0.73780179
59MAP3K60.70981684
60IRAK20.69814665
61PTK2B0.68784848
62EPHA30.68233099
63PRKD20.66277287
64PDPK10.63820010
65FGFR40.63373113
66CAMKK20.63274491
67MAP3K70.62581234
68PIM10.59314890
69NLK0.58088575
70STK110.57918324
71RAF10.56722716
72DYRK1B0.54990060
73MAPK120.54215515
74SIK20.53827673
75TAOK20.51793598
76MAP2K60.49476738
77SGK30.49164465
78MAPK70.48664896
79MAP3K50.47039391
80GRK70.46376003
81CAMKK10.45101625
82MAP2K40.44576845
83MAP2K20.42610620
84STK380.42491025
85HIPK20.41731728
86CDC42BPA0.41315091
87SGK20.40535514
88RET0.40282525
89MAPKAPK20.39674903
90KSR10.39004562
91TRIB30.38561061
92WNK10.38482689
93RPS6KL10.32042427
94RPS6KC10.32042427
95KDR0.31665487
96DAPK20.30963518
97RPS6KA60.29569937
98PRKCH0.26438634
99CDK40.25400817
100PRKCD0.24549566

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.12027622
2Osteoclast differentiation_Homo sapiens_hsa043802.92253496
3Graft-versus-host disease_Homo sapiens_hsa053322.76981651
4Primary immunodeficiency_Homo sapiens_hsa053402.75825073
5Staphylococcus aureus infection_Homo sapiens_hsa051502.74547027
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.71716644
7Allograft rejection_Homo sapiens_hsa053302.66023587
8Autoimmune thyroid disease_Homo sapiens_hsa053202.53045628
9B cell receptor signaling pathway_Homo sapiens_hsa046622.26952991
10Tuberculosis_Homo sapiens_hsa051522.13801516
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11335627
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.05731165
13Antigen processing and presentation_Homo sapiens_hsa046122.04636811
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04555191
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00952479
16T cell receptor signaling pathway_Homo sapiens_hsa046601.97511594
17Type I diabetes mellitus_Homo sapiens_hsa049401.96526504
18Measles_Homo sapiens_hsa051621.91851636
19Hematopoietic cell lineage_Homo sapiens_hsa046401.90744693
20Malaria_Homo sapiens_hsa051441.86719713
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.84616171
22Chemokine signaling pathway_Homo sapiens_hsa040621.70526257
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69486207
24Viral myocarditis_Homo sapiens_hsa054161.59477024
25Acute myeloid leukemia_Homo sapiens_hsa052211.58875985
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.57247024
27Asthma_Homo sapiens_hsa053101.52262598
28Toxoplasmosis_Homo sapiens_hsa051451.51799399
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.51710047
30Legionellosis_Homo sapiens_hsa051341.51372766
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46698091
32Influenza A_Homo sapiens_hsa051641.45370426
33Herpes simplex infection_Homo sapiens_hsa051681.40045343
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31202335
35Phagosome_Homo sapiens_hsa041451.30453985
36Non-small cell lung cancer_Homo sapiens_hsa052231.26889008
37TNF signaling pathway_Homo sapiens_hsa046681.23367868
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.21495950
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18330756
40Platelet activation_Homo sapiens_hsa046111.16150803
41African trypanosomiasis_Homo sapiens_hsa051431.13829173
42Hepatitis B_Homo sapiens_hsa051611.08243630
43Rheumatoid arthritis_Homo sapiens_hsa053231.06757933
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06324188
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05695594
46Hepatitis C_Homo sapiens_hsa051600.98422120
47Apoptosis_Homo sapiens_hsa042100.96261418
48Pertussis_Homo sapiens_hsa051330.96022642
49Shigellosis_Homo sapiens_hsa051310.91947821
50Salmonella infection_Homo sapiens_hsa051320.88969191
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88774172
52Pancreatic cancer_Homo sapiens_hsa052120.85516358
53Prolactin signaling pathway_Homo sapiens_hsa049170.81008799
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80845776
55VEGF signaling pathway_Homo sapiens_hsa043700.79749946
56Other glycan degradation_Homo sapiens_hsa005110.78839737
57Chronic myeloid leukemia_Homo sapiens_hsa052200.76823744
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76540249
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75601381
60Endocytosis_Homo sapiens_hsa041440.75204830
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.70626526
62Epstein-Barr virus infection_Homo sapiens_hsa051690.65642082
63FoxO signaling pathway_Homo sapiens_hsa040680.64298615
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63249121
65Renal cell carcinoma_Homo sapiens_hsa052110.62605055
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.61481804
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.61331549
68Regulation of autophagy_Homo sapiens_hsa041400.61303466
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61300632
70Lysosome_Homo sapiens_hsa041420.59044206
71Dorso-ventral axis formation_Homo sapiens_hsa043200.58388224
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57827618
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.57157076
74Viral carcinogenesis_Homo sapiens_hsa052030.56913731
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56641301
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56316306
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54958987
78HTLV-I infection_Homo sapiens_hsa051660.51916973
79Choline metabolism in cancer_Homo sapiens_hsa052310.50287618
80Notch signaling pathway_Homo sapiens_hsa043300.50157239
81Endometrial cancer_Homo sapiens_hsa052130.47969459
82GnRH signaling pathway_Homo sapiens_hsa049120.47209519
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45623696
84Inositol phosphate metabolism_Homo sapiens_hsa005620.45189320
85MAPK signaling pathway_Homo sapiens_hsa040100.42664912
86mTOR signaling pathway_Homo sapiens_hsa041500.42306923
87Insulin resistance_Homo sapiens_hsa049310.42076854
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41995021
89Amoebiasis_Homo sapiens_hsa051460.41577340
90HIF-1 signaling pathway_Homo sapiens_hsa040660.41133611
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39662246
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.38697112
93Colorectal cancer_Homo sapiens_hsa052100.35751258
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34577566
95Rap1 signaling pathway_Homo sapiens_hsa040150.32307743
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.30770339
97Type II diabetes mellitus_Homo sapiens_hsa049300.30238460
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28701091
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27648862
100Long-term potentiation_Homo sapiens_hsa047200.26751164

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