JARID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.31119330
2nuclear pore complex assembly (GO:0051292)5.23576063
3negative regulation of translation, ncRNA-mediated (GO:0040033)5.20275629
4regulation of translation, ncRNA-mediated (GO:0045974)5.20275629
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)5.20275629
6regulation of gene silencing by RNA (GO:0060966)5.19258107
7regulation of posttranscriptional gene silencing (GO:0060147)5.19258107
8regulation of gene silencing by miRNA (GO:0060964)5.19258107
9regulation of DNA methylation (GO:0044030)4.78788377
10regulation of helicase activity (GO:0051095)4.55864443
11establishment of integrated proviral latency (GO:0075713)4.44343423
12regulation of chromatin silencing (GO:0031935)4.35080301
13pre-miRNA processing (GO:0031054)4.20478334
14mitotic metaphase plate congression (GO:0007080)4.11091069
15protein complex localization (GO:0031503)4.09984540
16pore complex assembly (GO:0046931)4.08099692
17positive regulation of histone H3-K4 methylation (GO:0051571)4.06617224
18protein localization to kinetochore (GO:0034501)3.98769815
19DNA replication-dependent nucleosome assembly (GO:0006335)3.91634864
20DNA replication-dependent nucleosome organization (GO:0034723)3.91634864
21mitotic nuclear envelope disassembly (GO:0007077)3.86907679
22histone H3-K36 demethylation (GO:0070544)3.83982508
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.78635110
24histone H4-K12 acetylation (GO:0043983)3.75141369
25DNA replication initiation (GO:0006270)3.73601209
26nucleobase biosynthetic process (GO:0046112)3.72613905
27ribosome assembly (GO:0042255)3.71089354
28single strand break repair (GO:0000012)3.69980593
29mitotic G2/M transition checkpoint (GO:0044818)3.68832469
30metaphase plate congression (GO:0051310)3.63844683
31somatic hypermutation of immunoglobulin genes (GO:0016446)3.62533227
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.62533227
33regulation of mitotic spindle checkpoint (GO:1903504)3.61776527
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61776527
35kinetochore organization (GO:0051383)3.60729354
36regulation of telomere maintenance via telomerase (GO:0032210)3.60702241
37nuclear envelope disassembly (GO:0051081)3.60500770
38membrane disassembly (GO:0030397)3.60500770
39DNA replication checkpoint (GO:0000076)3.58995834
40DNA unwinding involved in DNA replication (GO:0006268)3.58028762
41IMP biosynthetic process (GO:0006188)3.55754479
42L-alpha-amino acid transmembrane transport (GO:1902475)3.55171889
43protein K6-linked ubiquitination (GO:0085020)3.52560159
44positive regulation of chromosome segregation (GO:0051984)3.49149139
45paraxial mesoderm development (GO:0048339)3.48266594
46regulation of cell fate specification (GO:0042659)3.45774291
47protein localization to chromosome, centromeric region (GO:0071459)3.43264356
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.41440225
49maturation of SSU-rRNA (GO:0030490)3.40590910
50kinetochore assembly (GO:0051382)3.40372880
51regulation of gene silencing (GO:0060968)3.39320118
52regulation of spindle organization (GO:0090224)3.38500924
53formation of translation preinitiation complex (GO:0001731)3.38295656
54purine nucleobase biosynthetic process (GO:0009113)3.37956930
55determination of adult lifespan (GO:0008340)3.35721783
56establishment of viral latency (GO:0019043)3.34728874
57mitotic sister chromatid segregation (GO:0000070)3.33128532
58chromatin remodeling at centromere (GO:0031055)3.32497328
59ribosome biogenesis (GO:0042254)3.31767803
60DNA strand elongation involved in DNA replication (GO:0006271)3.30886508
61DNA geometric change (GO:0032392)3.26645597
62DNA duplex unwinding (GO:0032508)3.26070078
63* negative regulation of histone methylation (GO:0031061)3.23470244
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23183763
65heterochromatin organization (GO:0070828)3.23102323
66establishment of chromosome localization (GO:0051303)3.22187402
67regulation of RNA export from nucleus (GO:0046831)3.19592490
68* regulation of histone H3-K9 methylation (GO:0051570)3.17517929
69mitotic G2 DNA damage checkpoint (GO:0007095)3.17241126
70positive regulation of SMAD protein import into nucleus (GO:0060391)3.16128610
71regulation of histone H3-K4 methylation (GO:0051569)3.15006374
72regulation of mitotic spindle organization (GO:0060236)3.14677329
73DNA replication-independent nucleosome assembly (GO:0006336)3.14560186
74DNA replication-independent nucleosome organization (GO:0034724)3.14560186
75DNA strand elongation (GO:0022616)3.13907735
76CENP-A containing nucleosome assembly (GO:0034080)3.13079967
77nucleosome disassembly (GO:0006337)3.12710481
78protein-DNA complex disassembly (GO:0032986)3.12710481
79chromatin silencing (GO:0006342)3.11809676
80spindle checkpoint (GO:0031577)3.10098143
81negative regulation of chromosome segregation (GO:0051985)3.07185722
82histone H2A monoubiquitination (GO:0035518)3.05088035
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04744054
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04744054
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.04744054
86regulation of histone H3-K27 methylation (GO:0061085)3.04358781
87mitotic sister chromatid cohesion (GO:0007064)3.04265567
88mitotic spindle checkpoint (GO:0071174)3.04216792
89IMP metabolic process (GO:0046040)3.03674614
90mitotic chromosome condensation (GO:0007076)3.02989078
91sister chromatid segregation (GO:0000819)3.02984422
92regulation of centrosome cycle (GO:0046605)3.02169115
93inner cell mass cell proliferation (GO:0001833)2.99672013
94regulation of chromosome segregation (GO:0051983)2.98336201
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98063893
96negative regulation of sister chromatid segregation (GO:0033046)2.98063893
97negative regulation of mitotic sister chromatid separation (GO:2000816)2.98063893
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98063893
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97001841
100spindle assembly checkpoint (GO:0071173)2.96920108
101ribonucleoprotein complex biogenesis (GO:0022613)2.95940975
102* positive regulation of histone methylation (GO:0031062)2.95428959
103folic acid-containing compound biosynthetic process (GO:0009396)2.95424617
104attachment of spindle microtubules to kinetochore (GO:0008608)2.95039973
105cellular protein complex localization (GO:0034629)2.94251781
106mitotic spindle assembly checkpoint (GO:0007094)2.93548526
107DNA topological change (GO:0006265)2.93311088
108telomere maintenance via semi-conservative replication (GO:0032201)2.92022333
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91577807
110mRNA stabilization (GO:0048255)2.91211823
111RNA stabilization (GO:0043489)2.91211823
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91013317
113histone exchange (GO:0043486)2.90237770
114protein localization to chromosome (GO:0034502)2.89713156
115regulation of sister chromatid segregation (GO:0033045)2.88025437
116regulation of mitotic sister chromatid separation (GO:0010965)2.88025437
117regulation of mitotic sister chromatid segregation (GO:0033047)2.88025437
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86131128
119regulation of double-strand break repair via homologous recombination (GO:0010569)2.85948965
120chromatin assembly (GO:0031497)2.84472668
121cell fate commitment involved in formation of primary germ layer (GO:0060795)2.84359010
122ribosomal large subunit biogenesis (GO:0042273)2.83975303
123mitotic recombination (GO:0006312)2.83407082
124meiotic chromosome segregation (GO:0045132)2.82110841
125ATP-dependent chromatin remodeling (GO:0043044)2.82032235
126regulation of centriole replication (GO:0046599)2.80491674
127chromatin assembly or disassembly (GO:0006333)2.80464748
128negative regulation of gene silencing (GO:0060969)2.80452929
129nuclear envelope organization (GO:0006998)2.79756581
130ncRNA catabolic process (GO:0034661)2.77411791
131regulation of spindle checkpoint (GO:0090231)2.76595168
132* regulation of histone methylation (GO:0031060)2.75875094
133negative regulation of telomerase activity (GO:0051974)2.74383433
134regulation of RNA stability (GO:0043487)2.74004438
135negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73971634
136negative regulation of RNA splicing (GO:0033119)2.72624745
137* negative regulation of histone modification (GO:0031057)2.71104381
138regulation of stem cell maintenance (GO:2000036)2.69535425
139regulation of mRNA stability (GO:0043488)2.69188044
140histone arginine methylation (GO:0034969)2.67623927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.80191182
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.47165524
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.83380984
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.74166307
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16029381
6* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.09195049
7* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.09195049
8* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.09195049
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98140354
10* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.92487738
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71687152
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68451198
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.66912283
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50489353
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.48660003
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.47136197
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36038400
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.33034420
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25924820
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22596670
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22314200
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.21812575
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21654784
24* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.20414564
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.16575804
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.12035311
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10947983
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.03934834
29* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.99967651
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.95714193
31* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.95247246
32XRN2_22483619_ChIP-Seq_HELA_Human1.90283209
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88947627
34* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.88699662
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.87723846
36* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86638953
37* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.82281964
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81064509
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80409694
40* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79481591
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.75164266
42* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.74126235
43AR_21909140_ChIP-Seq_LNCAP_Human1.69149870
44VDR_23849224_ChIP-Seq_CD4+_Human1.68887359
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.66346167
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65599625
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65204838
48* TP63_19390658_ChIP-ChIP_HaCaT_Human1.64421949
49* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64154757
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.63678448
51* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63189623
52* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.57132761
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57082725
54* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53672265
55* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.53567000
56TTF2_22483619_ChIP-Seq_HELA_Human1.50980900
57CIITA_25753668_ChIP-Seq_RAJI_Human1.49782071
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.49751637
59* FOXP3_21729870_ChIP-Seq_TREG_Human1.44661144
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42201865
61* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40159420
62* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39861052
63KDM5A_27292631_Chip-Seq_BREAST_Human1.35472823
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34548896
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.33559464
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.33555971
67* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31014872
68* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29966286
69* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29966286
70ELK1_19687146_ChIP-ChIP_HELA_Human1.29794675
71* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29516541
72DCP1A_22483619_ChIP-Seq_HELA_Human1.27244360
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25652280
74* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.25050703
75MYC_22102868_ChIP-Seq_BL_Human1.25021858
76* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.22598710
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22506905
78GABP_19822575_ChIP-Seq_HepG2_Human1.22103832
79* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20532400
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19353689
81* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.14178611
82* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.12663031
83EWS_26573619_Chip-Seq_HEK293_Human1.12241283
84* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12125797
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08923118
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08900005
87* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07161477
88* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07086002
89MYC_18940864_ChIP-ChIP_HL60_Human1.07005393
90* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06705473
91* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06191941
92* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05779260
93* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05154634
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04731989
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04654852
96TFEB_21752829_ChIP-Seq_HELA_Human1.01791577
97* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01357778
98* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00594974
99* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99560972
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98805437
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97670388
102KAP1_27257070_Chip-Seq_ESCs_Mouse0.97432362
103ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97212898
104* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94954202
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94355111
106NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94303658
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93771051
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93369907
109* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93193835
110BP1_19119308_ChIP-ChIP_Hs578T_Human0.92611871
111HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91431084
112* SOX2_16153702_ChIP-ChIP_HESCs_Human0.91374211
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90527040
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89727695
115* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88116996
116EZH2_22144423_ChIP-Seq_EOC_Human0.87789088
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87444957
118* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86542016
119* NANOG_16153702_ChIP-ChIP_HESCs_Human0.85729027
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83119660
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.81701755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.94276371
2MP0003693_abnormal_embryo_hatching4.55455379
3MP0008057_abnormal_DNA_replication4.42669963
4MP0003111_abnormal_nucleus_morphology4.39292744
5MP0010094_abnormal_chromosome_stability4.13640154
6MP0004957_abnormal_blastocyst_morpholog3.91944333
7MP0003077_abnormal_cell_cycle3.55105215
8MP0008058_abnormal_DNA_repair3.20197689
9MP0008877_abnormal_DNA_methylation2.59310360
10MP0003123_paternal_imprinting2.39012030
11MP0001730_embryonic_growth_arrest2.37958642
12MP0008007_abnormal_cellular_replicative2.37929237
13MP0010352_gastrointestinal_tract_polyps2.34402700
14MP0003786_premature_aging2.32155973
15MP0000350_abnormal_cell_proliferation2.31387619
16MP0009278_abnormal_bone_marrow2.27016671
17MP0008932_abnormal_embryonic_tissue2.24824122
18MP0003941_abnormal_skin_development2.19266797
19MP0001672_abnormal_embryogenesis/_devel2.02668717
20MP0005380_embryogenesis_phenotype2.02668717
21MP0002653_abnormal_ependyma_morphology2.00023881
22MP0001188_hyperpigmentation1.98630608
23MP0002084_abnormal_developmental_patter1.93071499
24MP0006292_abnormal_olfactory_placode1.92791450
25MP0003890_abnormal_embryonic-extraembry1.89658522
26* MP0002085_abnormal_embryonic_tissue1.88889237
27MP0003136_yellow_coat_color1.88877268
28MP0010307_abnormal_tumor_latency1.80000707
29* MP0001697_abnormal_embryo_size1.79514910
30MP0004133_heterotaxia1.75469863
31MP0003121_genomic_imprinting1.75441128
32MP0003718_maternal_effect1.75184638
33MP0003984_embryonic_growth_retardation1.74503746
34MP0001293_anophthalmia1.73904658
35MP0002088_abnormal_embryonic_growth/wei1.73781049
36MP0002086_abnormal_extraembryonic_tissu1.68351558
37MP0003119_abnormal_digestive_system1.64098793
38MP0005367_renal/urinary_system_phenotyp1.60472695
39MP0000516_abnormal_urinary_system1.60472695
40* MP0004197_abnormal_fetal_growth/weight/1.59610192
41MP0005076_abnormal_cell_differentiation1.58181917
42MP0003315_abnormal_perineum_morphology1.57443496
43* MP0002080_prenatal_lethality1.50056027
44MP0010030_abnormal_orbit_morphology1.40154477
45MP0002210_abnormal_sex_determination1.37505713
46MP0000537_abnormal_urethra_morphology1.32420544
47MP0003303_peritoneal_inflammation1.30293845
48MP0000313_abnormal_cell_death1.26116899
49MP0000490_abnormal_crypts_of1.24744603
50MP0001145_abnormal_male_reproductive1.19940124
51MP0003937_abnormal_limbs/digits/tail_de1.16541524
52MP0001286_abnormal_eye_development1.10363173
53MP0008995_early_reproductive_senescence1.10294601
54MP0001545_abnormal_hematopoietic_system1.10152173
55MP0005397_hematopoietic_system_phenotyp1.10152173
56MP0003950_abnormal_plasma_membrane1.09671457
57MP0001853_heart_inflammation1.08641556
58MP0003787_abnormal_imprinting1.08171667
59MP0002396_abnormal_hematopoietic_system1.07696803
60MP0009703_decreased_birth_body1.07003092
61MP0001929_abnormal_gametogenesis1.01672757
62MP0000653_abnormal_sex_gland1.00074883
63MP0009053_abnormal_anal_canal1.00059716
64MP0002019_abnormal_tumor_incidence0.99404927
65* MP0003567_abnormal_fetal_cardiomyocyte0.98765887
66MP0009672_abnormal_birth_weight0.97943969
67* MP0002398_abnormal_bone_marrow0.94380002
68MP0002111_abnormal_tail_morphology0.92710792
69MP0004185_abnormal_adipocyte_glucose0.91583000
70* MP0003861_abnormal_nervous_system0.91393056
71MP0005499_abnormal_olfactory_system0.89971591
72MP0005394_taste/olfaction_phenotype0.89971591
73MP0005410_abnormal_fertilization0.89838376
74MP0002092_abnormal_eye_morphology0.88447067
75MP0000432_abnormal_head_morphology0.87772393
76MP0002697_abnormal_eye_size0.85914208
77MP0003566_abnormal_cell_adhesion0.84907310
78MP0005647_abnormal_sex_gland0.84592716
79* MP0002722_abnormal_immune_system0.84134643
80MP0006035_abnormal_mitochondrial_morpho0.83917633
81MP0006072_abnormal_retinal_apoptosis0.83168572
82MP0003806_abnormal_nucleotide_metabolis0.82750258
83MP0003221_abnormal_cardiomyocyte_apopto0.82613088
84* MP0000689_abnormal_spleen_morphology0.81221104
85MP0005671_abnormal_response_to0.80975084
86MP0005377_hearing/vestibular/ear_phenot0.80444604
87MP0003878_abnormal_ear_physiology0.80444604
88MP0003936_abnormal_reproductive_system0.80386541
89MP0003646_muscle_fatigue0.76901721
90MP0004264_abnormal_extraembryonic_tissu0.76762076
91MP0001119_abnormal_female_reproductive0.75824934
92MP0001849_ear_inflammation0.74697694
93MP0002089_abnormal_postnatal_growth/wei0.74408266
94MP0005384_cellular_phenotype0.73784852
95MP0002160_abnormal_reproductive_system0.72559792
96MP0002161_abnormal_fertility/fecundity0.71689066
97MP0000049_abnormal_middle_ear0.71152433
98MP0005621_abnormal_cell_physiology0.71011006
99MP0005395_other_phenotype0.69957439
100MP0002127_abnormal_cardiovascular_syste0.68567894
101MP0005501_abnormal_skin_physiology0.68468322
102MP0003755_abnormal_palate_morphology0.68100387
103MP0005391_vision/eye_phenotype0.67956721
104MP0003935_abnormal_craniofacial_develop0.67523519
105MP0005389_reproductive_system_phenotype0.67370801
106* MP0000703_abnormal_thymus_morphology0.67068143
107MP0000428_abnormal_craniofacial_morphol0.65981357
108* MP0002925_abnormal_cardiovascular_devel0.65374384
109MP0001915_intracranial_hemorrhage0.64868173
110MP0002009_preneoplasia0.64095953
111MP0005075_abnormal_melanosome_morpholog0.63060296
112MP0003698_abnormal_male_reproductive0.62800692
113MP0000371_diluted_coat_color0.62674906
114MP0003122_maternal_imprinting0.62627747
115MP0004808_abnormal_hematopoietic_stem0.60954451
116MP0000579_abnormal_nail_morphology0.60677204
117* MP0002429_abnormal_blood_cell0.60117226
118MP0000716_abnormal_immune_system0.59945248
119MP0002233_abnormal_nose_morphology0.59730832
120MP0001919_abnormal_reproductive_system0.59682987
121MP0003448_altered_tumor_morphology0.59292764
122MP0002075_abnormal_coat/hair_pigmentati0.59278875
123MP0003453_abnormal_keratinocyte_physiol0.59222524
124MP0008770_decreased_survivor_rate0.58659747
125MP0008789_abnormal_olfactory_epithelium0.58026107
126MP0002751_abnormal_autonomic_nervous0.57783798
127MP0002249_abnormal_larynx_morphology0.57696441
128MP0003938_abnormal_ear_development0.57150876
129MP0002277_abnormal_respiratory_mucosa0.56264673
130MP0000627_abnormal_mammary_gland0.56021243
131MP0002796_impaired_skin_barrier0.54641154
132MP0003699_abnormal_female_reproductive0.54010971

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.69541550
2Abnormality of the labia minora (HP:0012880)3.98361208
3Chromsome breakage (HP:0040012)3.89215710
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.79925054
5Medulloblastoma (HP:0002885)3.76447869
6Birth length less than 3rd percentile (HP:0003561)3.71991410
7Absent radius (HP:0003974)3.69413212
8Embryonal renal neoplasm (HP:0011794)3.47746635
9Neoplasm of the oral cavity (HP:0100649)3.46930723
10Aplasia involving forearm bones (HP:0009822)3.46588908
11Absent forearm bone (HP:0003953)3.46588908
12Hepatoblastoma (HP:0002884)3.44864600
13Breast hypoplasia (HP:0003187)3.38875001
14Multiple enchondromatosis (HP:0005701)3.26277915
15Astrocytoma (HP:0009592)3.22615387
16Abnormality of the astrocytes (HP:0100707)3.22615387
17Impulsivity (HP:0100710)3.22328990
18Patellar aplasia (HP:0006443)3.21044098
19Agnosia (HP:0010524)3.16451353
20Supernumerary spleens (HP:0009799)3.15011656
21Homocystinuria (HP:0002156)3.12153543
22Abnormality of homocysteine metabolism (HP:0010919)3.12153543
23Carpal bone hypoplasia (HP:0001498)3.10965166
24Abnormality of the septum pellucidum (HP:0007375)3.09771756
25Glioma (HP:0009733)3.08245689
26Spastic diplegia (HP:0001264)3.06480431
27Aplasia/Hypoplasia of the patella (HP:0006498)3.06174599
28Cortical dysplasia (HP:0002539)3.05247349
29Rhabdomyosarcoma (HP:0002859)3.04250265
30Abnormal hair whorl (HP:0010721)2.92168135
31Aplasia/hypoplasia of the humerus (HP:0006507)2.89610878
32Colon cancer (HP:0003003)2.89196408
33Meckel diverticulum (HP:0002245)2.87433726
34Bilateral microphthalmos (HP:0007633)2.87233594
35Maternal diabetes (HP:0009800)2.84470037
36Selective tooth agenesis (HP:0001592)2.81206667
37Absent septum pellucidum (HP:0001331)2.80360774
38Abnormality of chromosome stability (HP:0003220)2.79418917
39Abnormality of the ileum (HP:0001549)2.73418886
40Absent thumb (HP:0009777)2.69786275
41Ectopic kidney (HP:0000086)2.68695536
42Supernumerary bones of the axial skeleton (HP:0009144)2.64440973
43Neoplasm of striated muscle (HP:0009728)2.63425520
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.63368227
45Abnormality of the preputium (HP:0100587)2.62929759
46Choanal stenosis (HP:0000452)2.62743683
47Acute lymphatic leukemia (HP:0006721)2.60027270
48Short humerus (HP:0005792)2.59716804
49Abnormal number of incisors (HP:0011064)2.59045135
50Abnormality of the anterior horn cell (HP:0006802)2.58131474
51Degeneration of anterior horn cells (HP:0002398)2.58131474
52Rib fusion (HP:0000902)2.57910309
53Rectal fistula (HP:0100590)2.55770945
54Rectovaginal fistula (HP:0000143)2.55770945
55Anal stenosis (HP:0002025)2.55464142
56Supernumerary ribs (HP:0005815)2.54845938
57Shawl scrotum (HP:0000049)2.52819516
58Reticulocytopenia (HP:0001896)2.51716609
59Amaurosis fugax (HP:0100576)2.49460064
60Stenosis of the external auditory canal (HP:0000402)2.49270496
61Esophageal atresia (HP:0002032)2.49218935
62Intestinal fistula (HP:0100819)2.47069994
63Protruding tongue (HP:0010808)2.46822378
64Aqueductal stenosis (HP:0002410)2.43919984
65Biliary tract neoplasm (HP:0100574)2.41539852
66Abdominal situs inversus (HP:0003363)2.41101809
67Abnormality of abdominal situs (HP:0011620)2.41101809
68Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40490380
69Cellular immunodeficiency (HP:0005374)2.39092647
70Duplicated collecting system (HP:0000081)2.35620676
71Abnormality of the salivary glands (HP:0010286)2.29383464
72Proximal placement of thumb (HP:0009623)2.29307087
73Stomatitis (HP:0010280)2.28518030
74T lymphocytopenia (HP:0005403)2.28356060
75Acute myeloid leukemia (HP:0004808)2.20849470
76Basal cell carcinoma (HP:0002671)2.19542521
77Myelodysplasia (HP:0002863)2.18494806
78Papillary thyroid carcinoma (HP:0002895)2.18237676
79Deviation of the thumb (HP:0009603)2.18134295
80Osteomalacia (HP:0002749)2.17047935
81Duodenal stenosis (HP:0100867)2.16940631
82Small intestinal stenosis (HP:0012848)2.16940631
83Volvulus (HP:0002580)2.15433584
84Horseshoe kidney (HP:0000085)2.12690741
85High anterior hairline (HP:0009890)2.11522877
86Facial hemangioma (HP:0000329)2.10178172
87Short thumb (HP:0009778)2.09708517
88Breast aplasia (HP:0100783)2.08784063
89Embryonal neoplasm (HP:0002898)2.08743240
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07425942
91Neoplasm of the adrenal cortex (HP:0100641)2.05682612
92Chronic bronchitis (HP:0004469)2.03736184
93Tracheoesophageal fistula (HP:0002575)2.01766477
94Missing ribs (HP:0000921)2.01176669
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.00885697
96Short 1st metacarpal (HP:0010034)2.00885697
97Leiomyosarcoma (HP:0100243)1.99946220
98Uterine leiomyosarcoma (HP:0002891)1.99946220
99Cleft eyelid (HP:0000625)1.98857825
100Neoplasm of the pancreas (HP:0002894)1.98820362
101Transitional cell carcinoma of the bladder (HP:0006740)1.98797909
102Abnormality of the renal collecting system (HP:0004742)1.98625246
103Malignant gastrointestinal tract tumors (HP:0006749)1.98250822
104Gastrointestinal carcinoma (HP:0002672)1.98250822
105Gastrointestinal atresia (HP:0002589)1.96873643
106Asplenia (HP:0001746)1.96212320
107Triphalangeal thumb (HP:0001199)1.95483002
108Optic nerve hypoplasia (HP:0000609)1.94467495
109Abnormality of the lacrimal duct (HP:0011481)1.92886739
110Broad thumb (HP:0011304)1.92661468
111Progressive external ophthalmoplegia (HP:0000590)1.92413804
112Uterine neoplasm (HP:0010784)1.92130406
113Abnormality of the duodenum (HP:0002246)1.91902473
114Bone marrow hypocellularity (HP:0005528)1.90615019
115Septo-optic dysplasia (HP:0100842)1.90614701
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.90226369
117Rough bone trabeculation (HP:0100670)1.89883334
118Vaginal fistula (HP:0004320)1.89543154
119Fused cervical vertebrae (HP:0002949)1.89037880
120Sloping forehead (HP:0000340)1.88056725
121Oral leukoplakia (HP:0002745)1.87886887
122Cafe-au-lait spot (HP:0000957)1.87561111
123Absent eyebrow (HP:0002223)1.86640621
124Cerebral hypomyelination (HP:0006808)1.86092022
125Aplasia/Hypoplasia of the breasts (HP:0010311)1.85918771
126Abnormality of the carotid arteries (HP:0005344)1.85626170
127Pancreatic islet-cell hyperplasia (HP:0004510)1.85539608
128Nephroblastoma (Wilms tumor) (HP:0002667)1.84626756
129Hypoplasia of the radius (HP:0002984)1.84196722
130Prominent nose (HP:0000448)1.83364170
131Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83008095
132Premature ovarian failure (HP:0008209)1.82247756
133Skull defect (HP:0001362)1.81326381
134Atresia of the external auditory canal (HP:0000413)1.80927404
135Abnormality of T cell number (HP:0011839)1.80888883
1362-3 toe syndactyly (HP:0004691)1.80725942
137Vertebral fusion (HP:0002948)1.80549801
138Abnormal lung lobation (HP:0002101)1.79309136
139Hypogonadotrophic hypogonadism (HP:0000044)1.78827197
140Increased nuchal translucency (HP:0010880)1.78031996
141Urethral obstruction (HP:0000796)1.76444115
142Primary amenorrhea (HP:0000786)1.76434762
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.75891739
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75843025
145Gonadotropin excess (HP:0000837)1.75163828
146Abnormality of the fingertips (HP:0001211)1.73761836
147IgM deficiency (HP:0002850)1.73327998
148Neuroblastic tumors (HP:0004376)1.72411634
149Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.72411634
150Primitive neuroectodermal tumor (HP:0030065)1.72411634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.13808081
2WEE14.08568526
3CDK124.01860263
4CDC73.57039607
5BUB13.31711352
6SRPK13.25247772
7TNIK3.22957788
8PNCK3.05874526
9TTK2.95389509
10TSSK62.80075391
11TAF12.67171107
12AKT32.55905647
13MKNK22.48580467
14NEK22.39002946
15BRD42.32884488
16MKNK12.27339963
17PLK11.98300922
18ZAK1.96727600
19MAP3K91.90994470
20RPS6KB21.90521041
21CDK191.88411259
22CDK71.87148319
23VRK21.82636599
24NEK11.80395333
25CAMK1G1.80137913
26PLK31.76556365
27CHEK21.75770688
28PLK41.75486139
29ATR1.72503649
30DYRK31.60486778
31EIF2AK11.52201465
32TLK11.51945961
33STK38L1.50643450
34CHEK11.48875908
35SMG11.48741582
36AURKB1.36785368
37ALK1.34750254
38NLK1.33687348
39CDK41.25933454
40STK41.23548397
41ATM1.21674488
42MATK1.20900838
43ACVR1B1.20592305
44PASK1.19458425
45AURKA1.13986342
46CDK21.12090253
47BRSK21.08564762
48PIM11.04993989
49MAP3K81.03117871
50FGR1.03115416
51MAP3K131.02220086
52PRKCI0.98801024
53TEC0.96894268
54STK100.94647081
55VRK10.92950347
56EIF2AK30.86333384
57TESK20.85467627
58MELK0.84637990
59CDK10.83112876
60MTOR0.76811346
61STK30.75281703
62CDK60.73617392
63PAK40.73209256
64BMX0.71386011
65CSNK1E0.70784333
66TRIM280.69261517
67CSNK2A20.69028335
68LATS10.67972716
69PRPF4B0.67690797
70CSNK1D0.66309287
71EIF2AK20.65107988
72MET0.64924357
73LATS20.64916466
74DYRK20.62404493
75SGK20.61309428
76EEF2K0.61070720
77FGFR20.57906913
78STK160.56162041
79PRKDC0.55798854
80CSNK1G10.55598217
81NME10.55296214
82CSNK2A10.55271390
83RPS6KA50.55111752
84PBK0.53107367
85BRAF0.52956204
86IRAK10.52707142
87MAP3K100.52595505
88EGFR0.52572011
89TGFBR10.52106226
90MAP3K140.52074551
91WNK10.51390293
92DYRK1A0.51259172
93MAPK140.51250940
94ICK0.51137991
95PAK10.50459900
96RIPK40.50031496
97DMPK0.49175305
98CHUK0.46646077
99GSK3B0.46298850
100FES0.45542609
101MST40.44877036
102AKT20.41309646
103IRAK20.40807662
104MAPK10.39006314
105SGK2230.38498066
106SGK4940.38498066
107IRAK30.38113084
108BCR0.37871834
109IRAK40.37546975
110MAP4K10.37132248
111NEK60.36647754
112AKT10.36604910
113MAPK100.35754327
114CSK0.35567244
115RPS6KA40.35357559
116SCYL20.34962256
117FLT30.34669586
118BRSK10.34410052
119WNK30.33369347
120STK240.31144765
121MARK30.30837399
122YES10.28919778
123CLK10.27209448
124CDK90.26180568
125MAPK80.22146593
126TYRO30.21149915
127FGFR10.20319612
128NUAK10.19866480
129CAMK1D0.19599442
130PDK20.18924582
131RPS6KA10.18131091
132RPS6KB10.17589832
133IKBKB0.17180888

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.13171455
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.10115547
3DNA replication_Homo sapiens_hsa030303.85384820
4RNA transport_Homo sapiens_hsa030133.47124557
5Spliceosome_Homo sapiens_hsa030403.42965223
6RNA polymerase_Homo sapiens_hsa030203.22450637
7Homologous recombination_Homo sapiens_hsa034402.99524067
8Fanconi anemia pathway_Homo sapiens_hsa034602.71522764
9Cell cycle_Homo sapiens_hsa041102.70039618
10Nucleotide excision repair_Homo sapiens_hsa034202.69052900
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.56956931
12One carbon pool by folate_Homo sapiens_hsa006702.55668446
13Base excision repair_Homo sapiens_hsa034102.52201090
14mRNA surveillance pathway_Homo sapiens_hsa030152.39625705
15Basal transcription factors_Homo sapiens_hsa030222.30767297
16Non-homologous end-joining_Homo sapiens_hsa034502.30513517
17Proteasome_Homo sapiens_hsa030502.29338880
18Ribosome_Homo sapiens_hsa030102.26623738
19RNA degradation_Homo sapiens_hsa030182.01036465
20Pyrimidine metabolism_Homo sapiens_hsa002401.87506927
21p53 signaling pathway_Homo sapiens_hsa041151.68543824
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61898708
23Epstein-Barr virus infection_Homo sapiens_hsa051691.33824651
24Systemic lupus erythematosus_Homo sapiens_hsa053221.33736893
25* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23135396
26Oocyte meiosis_Homo sapiens_hsa041141.15702507
27Herpes simplex infection_Homo sapiens_hsa051681.09539900
28MicroRNAs in cancer_Homo sapiens_hsa052061.09074298
29Viral carcinogenesis_Homo sapiens_hsa052031.08835251
30Hippo signaling pathway_Homo sapiens_hsa043901.07416611
31Basal cell carcinoma_Homo sapiens_hsa052171.07096127
32Purine metabolism_Homo sapiens_hsa002301.03104892
33Notch signaling pathway_Homo sapiens_hsa043301.01828341
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00290153
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98593104
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94851835
37Antigen processing and presentation_Homo sapiens_hsa046120.91240681
38Adherens junction_Homo sapiens_hsa045200.84132427
39Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83432424
40TGF-beta signaling pathway_Homo sapiens_hsa043500.82120368
41HTLV-I infection_Homo sapiens_hsa051660.79004289
42Hedgehog signaling pathway_Homo sapiens_hsa043400.78489692
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75538315
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68968128
45Tight junction_Homo sapiens_hsa045300.67795221
46B cell receptor signaling pathway_Homo sapiens_hsa046620.66457441
47Vitamin digestion and absorption_Homo sapiens_hsa049770.65150208
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64641284
49Thyroid cancer_Homo sapiens_hsa052160.63565082
50mTOR signaling pathway_Homo sapiens_hsa041500.62051961
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61092145
52Colorectal cancer_Homo sapiens_hsa052100.59170757
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.55835958
54Small cell lung cancer_Homo sapiens_hsa052220.54738356
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53845749
56Chemokine signaling pathway_Homo sapiens_hsa040620.53699919
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52897078
58Osteoclast differentiation_Homo sapiens_hsa043800.52551600
59Wnt signaling pathway_Homo sapiens_hsa043100.51831527
60Lysine degradation_Homo sapiens_hsa003100.51163805
61Alcoholism_Homo sapiens_hsa050340.50889777
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50383060
63Selenocompound metabolism_Homo sapiens_hsa004500.50112360
64Pathways in cancer_Homo sapiens_hsa052000.49843940
65Vitamin B6 metabolism_Homo sapiens_hsa007500.49680109
66Fructose and mannose metabolism_Homo sapiens_hsa000510.48535555
67Steroid biosynthesis_Homo sapiens_hsa001000.48148097
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48116360
69Non-small cell lung cancer_Homo sapiens_hsa052230.47371528
70Prostate cancer_Homo sapiens_hsa052150.46994764
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46985699
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45335611
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45193451
74Prolactin signaling pathway_Homo sapiens_hsa049170.44672392
75ErbB signaling pathway_Homo sapiens_hsa040120.43155165
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43121260
77Apoptosis_Homo sapiens_hsa042100.41223425
78Hematopoietic cell lineage_Homo sapiens_hsa046400.40969212
79Dorso-ventral axis formation_Homo sapiens_hsa043200.39732886
80Pancreatic cancer_Homo sapiens_hsa052120.39573197
81Legionellosis_Homo sapiens_hsa051340.39547202
82HIF-1 signaling pathway_Homo sapiens_hsa040660.38250122
83Pentose phosphate pathway_Homo sapiens_hsa000300.38063236
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37919816
85MAPK signaling pathway_Homo sapiens_hsa040100.37872387
86Long-term depression_Homo sapiens_hsa047300.36671204
87Phototransduction_Homo sapiens_hsa047440.36349615
88Regulation of autophagy_Homo sapiens_hsa041400.36280136
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35663698
90Influenza A_Homo sapiens_hsa051640.35283394
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.33783294
92Graft-versus-host disease_Homo sapiens_hsa053320.33510844
93Endometrial cancer_Homo sapiens_hsa052130.33190853
94Primary immunodeficiency_Homo sapiens_hsa053400.32508662
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.32411177
96FoxO signaling pathway_Homo sapiens_hsa040680.32330760
97Biosynthesis of amino acids_Homo sapiens_hsa012300.32131463
98Type II diabetes mellitus_Homo sapiens_hsa049300.31414922
99Measles_Homo sapiens_hsa051620.30870290
100Rap1 signaling pathway_Homo sapiens_hsa040150.30734593
101Acute myeloid leukemia_Homo sapiens_hsa052210.30686273
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.29872252
103Allograft rejection_Homo sapiens_hsa053300.27081763
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26296500
105Viral myocarditis_Homo sapiens_hsa054160.25561874
106TNF signaling pathway_Homo sapiens_hsa046680.24934079
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.23873386
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23168448
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23042000
110Folate biosynthesis_Homo sapiens_hsa007900.22688124
111Renal cell carcinoma_Homo sapiens_hsa052110.22307710
112Arachidonic acid metabolism_Homo sapiens_hsa005900.19751010
113Chronic myeloid leukemia_Homo sapiens_hsa052200.19533262
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19513274
115Melanoma_Homo sapiens_hsa052180.19215239
116Hepatitis B_Homo sapiens_hsa051610.17798504
117Autoimmune thyroid disease_Homo sapiens_hsa053200.16882671
118Inositol phosphate metabolism_Homo sapiens_hsa005620.15735091
119Proteoglycans in cancer_Homo sapiens_hsa052050.15383033
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.15193191
121Asthma_Homo sapiens_hsa053100.14822889
122Bladder cancer_Homo sapiens_hsa052190.14707115
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14476419
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13675780
125Linoleic acid metabolism_Homo sapiens_hsa005910.12493055
126T cell receptor signaling pathway_Homo sapiens_hsa046600.12153034
127Shigellosis_Homo sapiens_hsa051310.11699015

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