JAZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.83660586
2vocalization behavior (GO:0071625)5.54996332
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15771494
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.96226754
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.93240002
6synaptic vesicle exocytosis (GO:0016079)4.90912404
7protein localization to synapse (GO:0035418)4.82497015
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.78876234
9regulation of glutamate receptor signaling pathway (GO:1900449)4.62921084
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59443140
11presynaptic membrane assembly (GO:0097105)4.55551006
12postsynaptic membrane organization (GO:0001941)4.52671612
13regulation of synaptic vesicle exocytosis (GO:2000300)4.49467770
14synaptic vesicle maturation (GO:0016188)4.48499499
15glutamate secretion (GO:0014047)4.43229451
16neurotransmitter-gated ion channel clustering (GO:0072578)4.34347219
17locomotory exploration behavior (GO:0035641)4.20603538
18negative regulation of cell killing (GO:0031342)4.14617849
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14617849
20pyrimidine nucleobase catabolic process (GO:0006208)4.10210221
21layer formation in cerebral cortex (GO:0021819)4.04373666
22presynaptic membrane organization (GO:0097090)4.04085633
23neuron recognition (GO:0008038)4.01803539
24regulation of synaptic vesicle transport (GO:1902803)4.01368285
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.93605512
26exploration behavior (GO:0035640)3.88944313
27dendritic spine morphogenesis (GO:0060997)3.87110240
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.73746722
29neurotransmitter secretion (GO:0007269)3.70737429
30glutamate receptor signaling pathway (GO:0007215)3.67831688
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66934678
32proline transport (GO:0015824)3.58587484
33axonal fasciculation (GO:0007413)3.54969795
34innervation (GO:0060384)3.54549873
35nucleobase catabolic process (GO:0046113)3.53662067
36neuron-neuron synaptic transmission (GO:0007270)3.49616387
37synaptic transmission, glutamatergic (GO:0035249)3.47830409
38startle response (GO:0001964)3.47731628
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47635391
40dendrite morphogenesis (GO:0048813)3.45458647
41positive regulation of membrane potential (GO:0045838)3.44723385
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44235803
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.41950226
44regulation of cAMP-dependent protein kinase activity (GO:2000479)3.41634355
45positive regulation of synapse maturation (GO:0090129)3.40710779
46long-term synaptic potentiation (GO:0060291)3.37900246
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37010150
48detection of molecule of bacterial origin (GO:0032490)3.36492051
49regulation of vesicle fusion (GO:0031338)3.36284403
50microglial cell activation (GO:0001774)3.33470824
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32096434
52regulation of neuronal synaptic plasticity (GO:0048168)3.30946212
53response to histamine (GO:0034776)3.26522948
54activation of protein kinase A activity (GO:0034199)3.26351282
55synaptic vesicle endocytosis (GO:0048488)3.25966138
56regulation of synapse structural plasticity (GO:0051823)3.23085288
57positive regulation of synapse assembly (GO:0051965)3.23014742
58regulation of postsynaptic membrane potential (GO:0060078)3.22125700
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.18171106
60response to pheromone (GO:0019236)3.15357329
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15025432
62detection of calcium ion (GO:0005513)3.14621250
63synapse assembly (GO:0007416)3.13207673
64striatum development (GO:0021756)3.13032075
65oxygen transport (GO:0015671)3.06653145
66cochlea development (GO:0090102)3.05739376
67central nervous system projection neuron axonogenesis (GO:0021952)3.04572896
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04329033
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04064398
70neurotransmitter transport (GO:0006836)3.04054280
71cerebellar granule cell differentiation (GO:0021707)3.04033880
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03701767
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03098868
74long-term memory (GO:0007616)3.02998262
75positive regulation of gamma-delta T cell activation (GO:0046645)3.02407119
76regulation of beta-amyloid formation (GO:1902003)3.01775757
77neuronal action potential propagation (GO:0019227)3.00207389
78neutrophil mediated immunity (GO:0002446)2.99840516
79positive regulation by symbiont of host defense response (GO:0052509)2.99266648
80modulation by symbiont of host defense response (GO:0052031)2.99266648
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99266648
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99266648
83positive regulation by organism of defense response of other organism involved in symbiotic interact2.99266648
84modulation by symbiont of host immune response (GO:0052553)2.99266648
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98323636
86calcium ion-dependent exocytosis (GO:0017156)2.98203450
87regulation of calcium ion-dependent exocytosis (GO:0017158)2.97513627
88production of molecular mediator involved in inflammatory response (GO:0002532)2.96055634
89hemoglobin metabolic process (GO:0020027)2.95244144
90dendrite development (GO:0016358)2.94730446
91macrophage activation involved in immune response (GO:0002281)2.94587424
92positive regulation of fibroblast migration (GO:0010763)2.94339561
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.94254129
94cell migration in hindbrain (GO:0021535)2.93132242
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92588770
96regulation of synaptic plasticity (GO:0048167)2.92582318
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92132056
98regulation of B cell receptor signaling pathway (GO:0050855)2.91714465
99regulation of dendritic spine morphogenesis (GO:0061001)2.91641429
100negative regulation of cAMP-mediated signaling (GO:0043951)2.91240087
101cerebellar Purkinje cell differentiation (GO:0021702)2.90111749
102auditory behavior (GO:0031223)2.89296046
103activated T cell proliferation (GO:0050798)2.88715842
104gamma-aminobutyric acid transport (GO:0015812)2.87267213
105regulation of neurotransmitter secretion (GO:0046928)2.86538848
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86257862
107dopamine biosynthetic process (GO:0042416)2.85967820
108intraspecies interaction between organisms (GO:0051703)2.82580933
109social behavior (GO:0035176)2.82580933
110transmission of nerve impulse (GO:0019226)2.80778588
111response to methylmercury (GO:0051597)2.80580091
112cellular response to epinephrine stimulus (GO:0071872)2.80499510
113positive regulation of dendritic spine morphogenesis (GO:0061003)2.78718189
114behavioral defense response (GO:0002209)2.78114776
115behavioral fear response (GO:0001662)2.78114776
116regulation of synapse assembly (GO:0051963)2.78045887
117organelle transport along microtubule (GO:0072384)2.76774603
118positive regulation of neurotransmitter secretion (GO:0001956)2.76552119
119membrane depolarization (GO:0051899)2.76144474
120learning (GO:0007612)2.75467370
121righting reflex (GO:0060013)2.75310008
122clathrin coat assembly (GO:0048268)2.74848452
123vesicle transport along microtubule (GO:0047496)2.74508689
124neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.74250550
125myeloid leukocyte mediated immunity (GO:0002444)2.74205004
126synapse organization (GO:0050808)2.74030020
127axon extension (GO:0048675)2.72828133
128regulation of synapse maturation (GO:0090128)2.72557335
129fear response (GO:0042596)2.71236036
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.70351039
131regulation of neurotransmitter levels (GO:0001505)2.70236293
132cellular extravasation (GO:0045123)2.66935039
133erythrocyte development (GO:0048821)2.65908994
134protoporphyrinogen IX metabolic process (GO:0046501)2.63692006
135gas transport (GO:0015669)2.62463562
136detection of external biotic stimulus (GO:0098581)2.59365399
137regulation of T-helper 2 cell differentiation (GO:0045628)2.57950433
138macrophage activation (GO:0042116)2.56944597
139detection of other organism (GO:0098543)2.56407736
140negative regulation of neurotransmitter transport (GO:0051589)2.55016776
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.53984313
142positive regulation of neurotransmitter transport (GO:0051590)2.52516988
143protein targeting to Golgi (GO:0000042)2.51831568
144positive regulation of cellular amide metabolic process (GO:0034250)2.50443105
145negative regulation of T cell mediated immunity (GO:0002710)2.50245449
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.48749740
147response to peptidoglycan (GO:0032494)2.45883620
148positive regulation of Rap GTPase activity (GO:0032854)2.44501173
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43474349
150negative regulation of T-helper cell differentiation (GO:0045623)2.42369355
151negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.42369355
152glycine transport (GO:0015816)2.40983063
153regulation of interferon-beta biosynthetic process (GO:0045357)2.39297164
154regulation of cellular amide metabolic process (GO:0034248)2.38718376
155regulation of type B pancreatic cell apoptotic process (GO:2000674)2.38618618
156establishment of protein localization to Golgi (GO:0072600)2.38578972
157response to epinephrine (GO:0071871)2.38016648
158phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36104894
159negative regulation of interleukin-12 production (GO:0032695)2.35832839
160L-amino acid import (GO:0043092)2.33618128
161regulation of clathrin-mediated endocytosis (GO:2000369)2.31590183
162regulation of platelet aggregation (GO:0090330)2.31503622
163regulation of Rap GTPase activity (GO:0032317)2.29831307
164positive regulation of granulocyte differentiation (GO:0030854)2.29049429
165response to host immune response (GO:0052572)2.28853683
166response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.28853683
167positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.28192847
168negative regulation of type 2 immune response (GO:0002829)2.26439003
169regulation of synaptic transmission, dopaminergic (GO:0032225)2.25159344
170negative regulation of leukocyte mediated immunity (GO:0002704)2.23938561
171regulation of gamma-delta T cell activation (GO:0046643)2.23631712
172positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.22912065
173regulation of ARF protein signal transduction (GO:0032012)2.22867292
174myeloid cell development (GO:0061515)2.19879626
175detection of bacterium (GO:0016045)2.19145819
176detection of biotic stimulus (GO:0009595)2.17310969
177regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.16919164
178leukocyte aggregation (GO:0070486)2.16107168
179neutrophil activation involved in immune response (GO:0002283)2.15809323
180antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.13737380
181regulation of cell maturation (GO:1903429)2.11658071
182negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.11415131
183cellular response to monoamine stimulus (GO:0071868)2.09424009
184cellular response to catecholamine stimulus (GO:0071870)2.09424009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45914209
2GBX2_23144817_ChIP-Seq_PC3_Human4.02619995
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08266638
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59462797
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52685871
6REST_21632747_ChIP-Seq_MESCs_Mouse2.51101321
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46716775
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40847962
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38507341
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34920796
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33854091
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27592680
13TAF15_26573619_Chip-Seq_HEK293_Human2.26493642
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23463361
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.22454263
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19202592
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16296797
18IGF1R_20145208_ChIP-Seq_DFB_Human2.13025321
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10784001
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08982245
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06500966
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06168928
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04207959
24* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02073639
25* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02073639
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01384872
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99497124
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97087365
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.94252988
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86201469
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85963535
32SMAD4_21799915_ChIP-Seq_A2780_Human1.85502295
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.84618681
34AR_21572438_ChIP-Seq_LNCaP_Human1.84503749
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83306692
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.83004904
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82153388
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80109821
39P300_19829295_ChIP-Seq_ESCs_Human1.78589955
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.78141323
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73742658
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72762376
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.69322289
44ZNF274_21170338_ChIP-Seq_K562_Hela1.68657132
45FUS_26573619_Chip-Seq_HEK293_Human1.64381519
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64174602
47RNF2_27304074_Chip-Seq_NSC_Mouse1.61995185
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60808305
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.59565186
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.58838399
51DROSHA_22980978_ChIP-Seq_HELA_Human1.58312242
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.57248219
53RUNX_20019798_ChIP-Seq_JUKART_Human1.54620606
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.53294936
55* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53203968
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.53099268
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51754663
58AR_25329375_ChIP-Seq_VCAP_Human1.50448069
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49451451
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48744657
61VDR_24787735_ChIP-Seq_THP-1_Human1.48515697
62* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48008115
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.47116533
64* STAT3_23295773_ChIP-Seq_U87_Human1.46836630
65KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.44344616
66* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41464698
67* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41453009
68TP53_16413492_ChIP-PET_HCT116_Human1.40202187
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40141947
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38363744
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38355796
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33652832
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32701735
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32155791
75GATA1_19941826_ChIP-Seq_K562_Human1.29254249
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28746092
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28416881
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.27419974
79* TCF4_23295773_ChIP-Seq_U87_Human1.26835683
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.25914685
81* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25603494
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23005228
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23005228
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22929107
85ER_23166858_ChIP-Seq_MCF-7_Human1.22302133
86RUNX2_22187159_ChIP-Seq_PCA_Human1.22105605
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21600078
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21482896
89* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21105419
90VDR_22108803_ChIP-Seq_LS180_Human1.19916728
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19905625
92* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19864117
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.18896267
94NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18852333
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18782554
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.17861370
97GATA1_22025678_ChIP-Seq_K562_Human1.16085813
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15765163
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15616284
100* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14017531
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13609913
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13309239
103AR_19668381_ChIP-Seq_PC3_Human1.10865283
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.10275429
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10040968
106JUN_21703547_ChIP-Seq_K562_Human1.10029329
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09997929
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09997929
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.09224617
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09153976
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08969504
112RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08832391
113P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08720968
114BCAT_22108803_ChIP-Seq_LS180_Human1.07599838
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06672388
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05629017
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05342887
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05113663
119* KDM2B_26808549_Chip-Seq_REH_Human1.05047653
120SMAD3_21741376_ChIP-Seq_ESCs_Human1.04161899
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03909105
122* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03429936
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.01832664
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.01230151
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00977469
126CMYC_18555785_Chip-Seq_ESCs_Mouse1.00224423
127WT1_19549856_ChIP-ChIP_CCG9911_Human1.00069965
128* SMRT_27268052_Chip-Seq_Bcells_Human0.99609476
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.98851019
130AHR_22903824_ChIP-Seq_MCF-7_Human0.98046437
131GATA2_19941826_ChIP-Seq_K562_Human0.97048302
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96430343
133P53_22387025_ChIP-Seq_ESCs_Mouse0.96074253
134* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95668416
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95358896
136CBP_20019798_ChIP-Seq_JUKART_Human0.94767273
137CRX_20693478_ChIP-Seq_RETINA_Mouse0.94341251
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93786573
139GATA2_21666600_ChIP-Seq_HMVEC_Human0.93666872
140OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93087079
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92744670
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92536136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.94458812
2MP0003880_abnormal_central_pattern4.35611668
3MP0004270_analgesia3.85187453
4MP0003635_abnormal_synaptic_transmissio3.70717772
5MP0003656_abnormal_erythrocyte_physiolo3.51396980
6MP0002063_abnormal_learning/memory/cond3.07964516
7MP0003724_increased_susceptibility_to3.03830888
8MP0009745_abnormal_behavioral_response2.98019376
9MP0008260_abnormal_autophagy2.84909590
10MP0002572_abnormal_emotion/affect_behav2.78303023
11MP0001968_abnormal_touch/_nociception2.73828891
12MP0002734_abnormal_mechanical_nocicepti2.69866148
13MP0009046_muscle_twitch2.59605999
14MP0002064_seizures2.59501377
15MP0003303_peritoneal_inflammation2.52116362
16MP0005423_abnormal_somatic_nervous2.42919431
17MP0000778_abnormal_nervous_system2.41658321
18MP0006082_CNS_inflammation2.39626573
19MP0009780_abnormal_chondrocyte_physiolo2.28419235
20MP0002735_abnormal_chemical_nociception2.25120987
21MP0003172_abnormal_lysosome_physiology2.17751793
22MP0002736_abnormal_nociception_after2.17192844
23MP0001440_abnormal_grooming_behavior2.16651972
24MP0000569_abnormal_digit_pigmentation2.14910971
25MP0006276_abnormal_autonomic_nervous2.14308985
26MP0002184_abnormal_innervation2.14203964
27MP0003122_maternal_imprinting2.12292116
28MP0003787_abnormal_imprinting2.09354163
29MP0001486_abnormal_startle_reflex2.06537219
30MP0002272_abnormal_nervous_system2.05762260
31MP0005646_abnormal_pituitary_gland2.04693788
32MP0004510_myositis2.04577761
33MP0001529_abnormal_vocalization2.03374809
34MP0002733_abnormal_thermal_nociception2.02824175
35MP0001984_abnormal_olfaction1.99389537
36MP0003690_abnormal_glial_cell1.95673234
37MP0002067_abnormal_sensory_capabilities1.85047126
38MP0001501_abnormal_sleep_pattern1.82031764
39MP0004924_abnormal_behavior1.81957406
40MP0005386_behavior/neurological_phenoty1.81957406
41MP0001970_abnormal_pain_threshold1.81050508
42MP0002557_abnormal_social/conspecific_i1.80513547
43MP0002822_catalepsy1.79296606
44MP0002837_dystrophic_cardiac_calcinosis1.68833785
45MP0004147_increased_porphyrin_level1.68035825
46MP0004811_abnormal_neuron_physiology1.67275108
47MP0002909_abnormal_adrenal_gland1.65723654
48MP0001188_hyperpigmentation1.59130821
49MP0006292_abnormal_olfactory_placode1.52880872
50MP0009785_altered_susceptibility_to1.52818811
51MP0000955_abnormal_spinal_cord1.51428763
52MP0003879_abnormal_hair_cell1.51406447
53MP0001905_abnormal_dopamine_level1.50626668
54MP0002332_abnormal_exercise_endurance1.48321633
55MP0001835_abnormal_antigen_presentation1.47384400
56MP0000013_abnormal_adipose_tissue1.46584062
57MP0002419_abnormal_innate_immunity1.44735976
58MP0004883_abnormal_blood_vessel1.43640308
59MP0005645_abnormal_hypothalamus_physiol1.42228243
60MP0003329_amyloid_beta_deposits1.41709051
61MP0010386_abnormal_urinary_bladder1.40254391
62MP0001986_abnormal_taste_sensitivity1.36773319
63MP0002882_abnormal_neuron_morphology1.35905758
64MP0001958_emphysema1.33119119
65MP0003436_decreased_susceptibility_to1.31545816
66MP0003300_gastrointestinal_ulcer1.30972792
67MP0002066_abnormal_motor_capabilities/c1.27288127
68MP0008569_lethality_at_weaning1.24578400
69MP0001502_abnormal_circadian_rhythm1.23904646
70MP0008877_abnormal_DNA_methylation1.23395558
71MP0000631_abnormal_neuroendocrine_gland1.22866702
72MP0008438_abnormal_cutaneous_collagen1.20125389
73MP0004484_altered_response_of1.18180301
74MP0002152_abnormal_brain_morphology1.16380490
75MP0003195_calcinosis1.16339352
76MP0008874_decreased_physiological_sensi1.12758248
77MP0005503_abnormal_tendon_morphology1.11947008
78MP0002102_abnormal_ear_morphology1.11761203
79MP0002638_abnormal_pupillary_reflex1.11500494
80MP0003121_genomic_imprinting1.10057701
81MP0005164_abnormal_response_to1.08374849
82MP0005000_abnormal_immune_tolerance1.07745519
83MP0004858_abnormal_nervous_system1.07482082
84MP0000685_abnormal_immune_system1.07454397
85MP0003191_abnormal_cellular_cholesterol1.06785937
86MP0005410_abnormal_fertilization1.05968872
87MP0000920_abnormal_myelination1.05958536
88MP0005025_abnormal_response_to1.04742049
89MP0002876_abnormal_thyroid_physiology1.03826624
90MP0003828_pulmonary_edema1.03793619
91MP0001800_abnormal_humoral_immune1.03199707
92MP0001790_abnormal_immune_system1.02178287
93MP0005387_immune_system_phenotype1.02178287
94MP0003183_abnormal_peptide_metabolism0.99653794
95MP0005499_abnormal_olfactory_system0.97551472
96MP0005394_taste/olfaction_phenotype0.97551472
97MP0001542_abnormal_bone_strength0.97490891
98MP0004142_abnormal_muscle_tone0.97317677
99MP0003045_fibrosis0.96914209
100MP0002420_abnormal_adaptive_immunity0.96177342
101MP0001533_abnormal_skeleton_physiology0.95401832
102MP0002723_abnormal_immune_serum0.95028217
103MP0004130_abnormal_muscle_cell0.94376215
104MP0006072_abnormal_retinal_apoptosis0.92970953
105MP0003091_abnormal_cell_migration0.92819437
106MP0005174_abnormal_tail_pigmentation0.91812669
107MP0008004_abnormal_stomach_pH0.91772696
108MP0001819_abnormal_immune_cell0.91710708
109MP0004085_abnormal_heartbeat0.91243573
110MP0002928_abnormal_bile_duct0.90188485
111MP0004742_abnormal_vestibular_system0.88944550
112MP0004885_abnormal_endolymph0.87147350
113MP0005379_endocrine/exocrine_gland_phen0.86527694
114MP0002069_abnormal_eating/drinking_beha0.85832781
115MP0002653_abnormal_ependyma_morphology0.85627268
116MP0005535_abnormal_body_temperature0.84512067
117MP0000604_amyloidosis0.83058472
118MP0005671_abnormal_response_to0.82935492
119MP0002752_abnormal_somatic_nervous0.82251699
120MP0003631_nervous_system_phenotype0.81032248
121MP0002452_abnormal_antigen_presenting0.80703680
122MP0003646_muscle_fatigue0.80611235
123MP0005551_abnormal_eye_electrophysiolog0.80366308
124MP0002751_abnormal_autonomic_nervous0.79890460
125MP0003633_abnormal_nervous_system0.79118131
126MP0002295_abnormal_pulmonary_circulatio0.78951800
127MP0000751_myopathy0.78753753
128MP0005075_abnormal_melanosome_morpholog0.78455818
129MP0001963_abnormal_hearing_physiology0.78226535
130MP0005310_abnormal_salivary_gland0.78116649
131MP0003861_abnormal_nervous_system0.76864792
132MP0002405_respiratory_system_inflammati0.75917540
133MP0002229_neurodegeneration0.75747983
134MP0003698_abnormal_male_reproductive0.74915918
135MP0004233_abnormal_muscle_weight0.74775398
136MP0002998_abnormal_bone_remodeling0.74199935
137MP0008789_abnormal_olfactory_epithelium0.71785971
138MP0003632_abnormal_nervous_system0.70680483
139MP0005187_abnormal_penis_morphology0.70335689
140MP0003119_abnormal_digestive_system0.68786751
141MP0003634_abnormal_glial_cell0.67523310
142MP0004145_abnormal_muscle_electrophysio0.67466687
143MP0005248_abnormal_Harderian_gland0.65531666
144MP0000015_abnormal_ear_pigmentation0.63705798
145MP0001299_abnormal_eye_distance/0.60850158
146MP0002693_abnormal_pancreas_physiology0.58474462
147MP0002090_abnormal_vision0.58260002
148MP0000026_abnormal_inner_ear0.57870015
149MP0004215_abnormal_myocardial_fiber0.57515495
150MP0003123_paternal_imprinting0.57455104
151MP0001664_abnormal_digestion0.56867466
152MP0001943_abnormal_respiration0.55871859

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.60285092
2Hypochromic microcytic anemia (HP:0004840)5.37808965
3Visual hallucinations (HP:0002367)4.70244866
4Myokymia (HP:0002411)4.67291367
5Focal seizures (HP:0007359)4.53193254
6Epileptic encephalopathy (HP:0200134)4.51496687
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.30917047
8Atonic seizures (HP:0010819)4.26880971
9Hyperventilation (HP:0002883)4.22196256
10Febrile seizures (HP:0002373)3.81462791
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.72128544
12Progressive cerebellar ataxia (HP:0002073)3.71158963
13Absence seizures (HP:0002121)3.67920452
14Microcytic anemia (HP:0001935)3.57833814
15Recurrent bacterial skin infections (HP:0005406)3.41528319
16Stomatitis (HP:0010280)3.38812673
17Postural instability (HP:0002172)3.35358759
18Broad-based gait (HP:0002136)3.34415926
19Dialeptic seizures (HP:0011146)3.27191358
20Generalized tonic-clonic seizures (HP:0002069)3.21467025
21Drooling (HP:0002307)3.19959882
22Excessive salivation (HP:0003781)3.19959882
23Polyphagia (HP:0002591)3.16998639
24Epileptiform EEG discharges (HP:0011182)3.06021069
25Peritonitis (HP:0002586)2.99765298
26Recurrent abscess formation (HP:0002722)2.99461249
27Poikilocytosis (HP:0004447)2.98313380
28Mutism (HP:0002300)2.95655107
29Limb dystonia (HP:0002451)2.94782449
30EEG with generalized epileptiform discharges (HP:0011198)2.94286898
31Optic neuritis (HP:0100653)2.91314979
32Retrobulbar optic neuritis (HP:0100654)2.91314979
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87962399
34Hypsarrhythmia (HP:0002521)2.82266724
35Amblyopia (HP:0000646)2.81651663
36Hypochromic anemia (HP:0001931)2.80943406
37Recurrent gram-negative bacterial infections (HP:0005420)2.78797545
38Eczematoid dermatitis (HP:0000976)2.78373988
39Agitation (HP:0000713)2.75788658
40Gait imbalance (HP:0002141)2.75108369
41Orchitis (HP:0100796)2.74213825
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.73152446
43Absent/shortened dynein arms (HP:0200106)2.73152446
44Toxemia of pregnancy (HP:0100603)2.72486037
45Hematochezia (HP:0002573)2.70973070
46Myositis (HP:0100614)2.70114867
47Abnormal eating behavior (HP:0100738)2.68959242
48Abnormality of macrophages (HP:0004311)2.67433846
49Amyotrophic lateral sclerosis (HP:0007354)2.63497474
50Ankle clonus (HP:0011448)2.59677431
51Increased circulating renin level (HP:0000848)2.59200942
52Papilledema (HP:0001085)2.58327703
53Absent speech (HP:0001344)2.56529487
54Progressive inability to walk (HP:0002505)2.55639604
55Supranuclear gaze palsy (HP:0000605)2.55132666
56Pheochromocytoma (HP:0002666)2.52724458
57Gastrointestinal infarctions (HP:0005244)2.52666003
58Poor eye contact (HP:0000817)2.52593255
59Spontaneous hematomas (HP:0007420)2.48113208
60Papillary thyroid carcinoma (HP:0002895)2.46191245
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46174550
62Anxiety (HP:0000739)2.45963753
63Protruding tongue (HP:0010808)2.44456957
64Resting tremor (HP:0002322)2.43460872
65Fetal akinesia sequence (HP:0001989)2.43411611
66Slow saccadic eye movements (HP:0000514)2.43226805
67Abnormal respiratory motile cilium physiology (HP:0012261)2.42583107
68T lymphocytopenia (HP:0005403)2.41529355
69Blue irides (HP:0000635)2.39855594
70Truncal ataxia (HP:0002078)2.39268761
71Bradykinesia (HP:0002067)2.39226875
72Abnormal hair whorl (HP:0010721)2.36865242
73Abnormality of the labia minora (HP:0012880)2.36538581
74Poor suck (HP:0002033)2.34570046
75Genetic anticipation (HP:0003743)2.32449755
76Akinesia (HP:0002304)2.31756644
77Episodic fever (HP:0001954)2.31236960
78Inability to walk (HP:0002540)2.30127387
79Gaze-evoked nystagmus (HP:0000640)2.29203215
80Depression (HP:0000716)2.28015645
81Ventricular fibrillation (HP:0001663)2.27839090
82Medial flaring of the eyebrow (HP:0010747)2.26856715
83Hemiplegia (HP:0002301)2.26679382
84Abnormality of T cell number (HP:0011839)2.25281135
85Impaired vibration sensation in the lower limbs (HP:0002166)2.23460189
86Facial hemangioma (HP:0000329)2.23013911
87Intention tremor (HP:0002080)2.22000109
88Striae distensae (HP:0001065)2.20820884
89Urinary bladder sphincter dysfunction (HP:0002839)2.20045495
90Gingival bleeding (HP:0000225)2.19575204
91Abnormal social behavior (HP:0012433)2.19155055
92Impaired social interactions (HP:0000735)2.19155055
93Insidious onset (HP:0003587)2.18414331
94Termporal pattern (HP:0011008)2.18414331
95Rigidity (HP:0002063)2.18273081
96Abnormality of the corticospinal tract (HP:0002492)2.17127607
97Cerebral inclusion bodies (HP:0100314)2.16446423
98Abnormality of calcium-phosphate metabolism (HP:0100530)2.15607675
99Abnormality of salivation (HP:0100755)2.13954157
100Inappropriate behavior (HP:0000719)2.12490764
101Decreased circulating renin level (HP:0003351)2.11947728
102Abnormal ciliary motility (HP:0012262)2.11815709
103Hepatoblastoma (HP:0002884)2.11431058
104Abnormality of liposaccharide metabolism (HP:0010968)2.10211113
105Abnormality of glycosphingolipid metabolism (HP:0004343)2.10211113
106Abnormality of glycolipid metabolism (HP:0010969)2.10211113
107Keratoconjunctivitis sicca (HP:0001097)2.09743197
108Failure to thrive in infancy (HP:0001531)2.06476052
109Hemiparesis (HP:0001269)2.05371372
110Action tremor (HP:0002345)2.05035019
111Neuroendocrine neoplasm (HP:0100634)2.04634944
112Neurofibrillary tangles (HP:0002185)2.03504737
113Spastic gait (HP:0002064)2.02570932
114Disinhibition (HP:0000734)2.02256316
115Generalized hypopigmentation of hair (HP:0011358)2.01392510
116Congenital primary aphakia (HP:0007707)2.00926424
117Hyperthyroidism (HP:0000836)2.00322853
118Impaired smooth pursuit (HP:0007772)1.98719880
119Urticaria (HP:0001025)1.98632796
120Torticollis (HP:0000473)1.97829197
121Recurrent skin infections (HP:0001581)1.96937025
122Rhinitis (HP:0012384)1.95676235
123Lissencephaly (HP:0001339)1.95037448
124Muscle fiber splitting (HP:0003555)1.93769987
125Stereotypic behavior (HP:0000733)1.93605572
126Thyroid carcinoma (HP:0002890)1.92948008
127Keratoconjunctivitis (HP:0001096)1.90797599
128Prolonged bleeding time (HP:0003010)1.90615667
129Cholelithiasis (HP:0001081)1.90205357
130Nuclear cataract (HP:0100018)1.89739535
131Abnormal respiratory epithelium morphology (HP:0012253)1.89622850
132Abnormal respiratory motile cilium morphology (HP:0005938)1.89622850
133Polycythemia (HP:0001901)1.89360829
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89291677
135Hypoplasia of the brainstem (HP:0002365)1.89291677
136Abnormality of binocular vision (HP:0011514)1.86969450
137Diplopia (HP:0000651)1.86969450
138Infertility (HP:0000789)1.85997823
139Abnormal gallbladder morphology (HP:0012437)1.85853659
140Chronic bronchitis (HP:0004469)1.85812259
141Gingivitis (HP:0000230)1.84795624
142Nephrogenic diabetes insipidus (HP:0009806)1.83976842
143Open mouth (HP:0000194)1.83847901
144Labial hypoplasia (HP:0000066)1.82802117
145Abnormal EKG (HP:0003115)1.79937434
146Dysmetria (HP:0001310)1.79795363
147Leukocytosis (HP:0001974)1.79242991
148Generalized myoclonic seizures (HP:0002123)1.79115024
149Absent eyebrow (HP:0002223)1.78276847
150Dysdiadochokinesis (HP:0002075)1.77969610
151Widely spaced teeth (HP:0000687)1.77961622
152Sporadic (HP:0003745)1.77262998
153Abnormality of ocular smooth pursuit (HP:0000617)1.76907439
154Aplasia/Hypoplasia of the lens (HP:0008063)1.76844359
155Abnormality of saccadic eye movements (HP:0000570)1.75775537
156Loss of speech (HP:0002371)1.75137558
157Autoamputation (HP:0001218)1.72917185
158Ocular albinism (HP:0001107)1.72262526
159Albinism (HP:0001022)1.71709815
160Iris hypopigmentation (HP:0007730)1.71416928
161Increased CSF protein (HP:0002922)1.69129870
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68829755
163Abnormality of polysaccharide metabolism (HP:0011012)1.68829755
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68829755
165Pulmonary infiltrates (HP:0002113)1.67897799
166Neuronal loss in central nervous system (HP:0002529)1.67346914
167Osteomyelitis (HP:0002754)1.66858090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.09160417
2NTRK34.06079924
3CASK3.97381320
4MAP3K43.25341027
5MAP2K72.98220326
6MAP3K92.94364331
7MAP3K122.53983326
8MAPK132.32427112
9EPHA42.28690400
10NTRK22.27869487
11MINK12.21108743
12PLK22.03865674
13BLK1.91765930
14LATS21.87855444
15MAP2K41.86357573
16IRAK41.75915799
17KSR11.75104575
18DAPK21.71066398
19PAK61.58874088
20GRK61.54751656
21TYK21.54175602
22DYRK21.53158618
23PRKD31.46535986
24MAP3K31.44310936
25SIK31.42151489
26MAP3K61.39385796
27MAP3K131.38359214
28GRK51.38041628
29DAPK11.37564523
30JAK11.37374667
31PHKG11.37362524
32PHKG21.37362524
33MAP2K31.36793216
34MUSK1.35072090
35PNCK1.32951321
36KSR21.27582390
37MAP3K11.26586633
38WNK11.25750763
39SIK21.25719253
40ERBB31.24280427
41CDK51.23828367
42PINK11.21293636
43NTRK11.20691013
44CSK1.19604019
45AKT31.18470986
46WNK31.17800570
47MAP3K21.15627201
48IKBKE1.14930912
49MAP3K111.13262315
50TNK21.13018165
51MARK31.09220635
52SYK1.07281171
53INSRR1.05494953
54PRKCG1.02034009
55CAMK2A1.00665589
56MAP4K10.99719991
57CSNK1G20.99501154
58TAOK30.96385825
59CCNB10.96172382
60BCR0.94020400
61MYLK0.93048399
62EPHA30.92976145
63ARAF0.90899800
64JAK20.90480042
65TXK0.89562566
66TAOK10.89276706
67TRPM70.88287602
68PAK30.88196185
69NLK0.88135346
70PRPF4B0.86250084
71UHMK10.84780077
72CDK180.84668827
73MARK20.84218482
74MOS0.81425694
75STK380.80986326
76EPHB10.80730343
77FRK0.79765953
78RET0.79559716
79TNIK0.79371370
80HCK0.77921717
81SGK20.77782072
82ERBB40.77768933
83CDK150.77005818
84PDK40.76304706
85PDK30.76304706
86CDK140.76219194
87BRAF0.74948876
88TGFBR20.74686031
89TAOK20.74261197
90YES10.73735002
91DYRK1A0.73030823
92ZAP700.72541829
93PRKCE0.72260257
94CDK190.72047597
95JAK30.71852011
96TEC0.71816937
97CAMK40.71190707
98SGK4940.71130019
99SGK2230.71130019
100RIPK40.69755720
101CAMKK10.69626268
102LYN0.66415631
103PDK10.64605826
104PTK2B0.63944312
105BMPR20.63658043
106CDK11A0.63640603
107SGK10.63576126
108HIPK20.62587705
109CAMK2B0.62307804
110ADRBK10.61390919
111TYRO30.60929693
112MAPK120.60227295
113CAMKK20.59185217
114RPS6KA20.59157506
115PIK3CG0.58708899
116STK110.58602204
117STK240.57900975
118RAF10.57885798
119DYRK30.54713328
120FES0.54498489
121IRAK20.54236234
122PRKCQ0.53456597
123MAPK70.52387932
124DMPK0.51895687
125NEK60.50859893
126PKN10.50843523
127FGR0.50088753
128PIM10.49181895
129MAP3K140.48571468
130STK40.47324107
131PRKCZ0.47169504
132CDK30.46172852
133CSNK1G30.45188747
134PRKCH0.44349637
135STK38L0.43481549
136PRKCI0.39817231
137RPS6KA30.36389460
138MAP3K50.34783301
139WNK40.33975610
140SGK30.32832824
141PRKAA10.32446528
142OXSR10.31867965
143PLK30.30916141
144PRKG10.30785615
145PRKCB0.29428175
146NME10.29255002
147CAMK10.28458599
148GRK70.28123364
149PRKACA0.28116441

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.85069598
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21555736
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70263113
4GABAergic synapse_Homo sapiens_hsa047272.54182251
5Circadian entrainment_Homo sapiens_hsa047132.48505516
6Morphine addiction_Homo sapiens_hsa050322.45721939
7Long-term potentiation_Homo sapiens_hsa047202.45432622
8Amphetamine addiction_Homo sapiens_hsa050312.41642947
9Glutamatergic synapse_Homo sapiens_hsa047242.27648479
10Olfactory transduction_Homo sapiens_hsa047402.27467211
11Dopaminergic synapse_Homo sapiens_hsa047282.20563549
12Insulin secretion_Homo sapiens_hsa049112.12240262
13Collecting duct acid secretion_Homo sapiens_hsa049662.07195045
14Serotonergic synapse_Homo sapiens_hsa047261.98509812
15Taste transduction_Homo sapiens_hsa047421.97719250
16Cocaine addiction_Homo sapiens_hsa050301.88290691
17Cholinergic synapse_Homo sapiens_hsa047251.84263783
18Malaria_Homo sapiens_hsa051441.83911775
19Osteoclast differentiation_Homo sapiens_hsa043801.75535195
20Renin secretion_Homo sapiens_hsa049241.72626961
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68391024
22Salivary secretion_Homo sapiens_hsa049701.67939817
23Long-term depression_Homo sapiens_hsa047301.66382543
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61317645
25Regulation of autophagy_Homo sapiens_hsa041401.60638416
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49608468
27Vibrio cholerae infection_Homo sapiens_hsa051101.48886154
28Gastric acid secretion_Homo sapiens_hsa049711.47816570
29Axon guidance_Homo sapiens_hsa043601.44533840
30Oxytocin signaling pathway_Homo sapiens_hsa049211.44122966
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39938634
32GnRH signaling pathway_Homo sapiens_hsa049121.38038816
33Type II diabetes mellitus_Homo sapiens_hsa049301.36334919
34Gap junction_Homo sapiens_hsa045401.33322216
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29832562
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29723271
37Calcium signaling pathway_Homo sapiens_hsa040201.28657304
38Estrogen signaling pathway_Homo sapiens_hsa049151.28336751
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28265218
40Tuberculosis_Homo sapiens_hsa051521.23410623
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19063914
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17671769
43cAMP signaling pathway_Homo sapiens_hsa040241.17025097
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14786854
45African trypanosomiasis_Homo sapiens_hsa051431.12313347
46FoxO signaling pathway_Homo sapiens_hsa040681.10853414
47T cell receptor signaling pathway_Homo sapiens_hsa046601.10670155
48Leishmaniasis_Homo sapiens_hsa051401.10547655
49B cell receptor signaling pathway_Homo sapiens_hsa046621.07674496
50ErbB signaling pathway_Homo sapiens_hsa040121.05241675
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02375573
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01974930
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99597405
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99231691
55Oocyte meiosis_Homo sapiens_hsa041140.98405946
56Glioma_Homo sapiens_hsa052140.96744972
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96398288
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94183126
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93241386
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.93227690
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92327102
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.91164919
63Non-small cell lung cancer_Homo sapiens_hsa052230.89425358
64Melanogenesis_Homo sapiens_hsa049160.88975752
65Staphylococcus aureus infection_Homo sapiens_hsa051500.86560327
66Dorso-ventral axis formation_Homo sapiens_hsa043200.85350305
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84901981
68Type I diabetes mellitus_Homo sapiens_hsa049400.82867689
69Glucagon signaling pathway_Homo sapiens_hsa049220.81508849
70Phototransduction_Homo sapiens_hsa047440.81264568
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.81040184
72Ovarian steroidogenesis_Homo sapiens_hsa049130.79692477
73Measles_Homo sapiens_hsa051620.78673821
74Cardiac muscle contraction_Homo sapiens_hsa042600.78349616
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77431425
76Oxidative phosphorylation_Homo sapiens_hsa001900.75143808
77Legionellosis_Homo sapiens_hsa051340.74553056
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73989333
79TNF signaling pathway_Homo sapiens_hsa046680.72415429
80MAPK signaling pathway_Homo sapiens_hsa040100.72055983
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72003729
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71832945
83Alzheimers disease_Homo sapiens_hsa050100.71481628
84Pertussis_Homo sapiens_hsa051330.70736425
85Hematopoietic cell lineage_Homo sapiens_hsa046400.68957577
86Dilated cardiomyopathy_Homo sapiens_hsa054140.68915370
87Ras signaling pathway_Homo sapiens_hsa040140.67273721
88Choline metabolism in cancer_Homo sapiens_hsa052310.66662646
89Renal cell carcinoma_Homo sapiens_hsa052110.65949013
90Circadian rhythm_Homo sapiens_hsa047100.65497057
91Platelet activation_Homo sapiens_hsa046110.64754745
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64248219
93Colorectal cancer_Homo sapiens_hsa052100.64092562
94Endometrial cancer_Homo sapiens_hsa052130.63101660
95Hepatitis B_Homo sapiens_hsa051610.62896800
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62860732
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62820018
98Thyroid hormone synthesis_Homo sapiens_hsa049180.62465904
99Amoebiasis_Homo sapiens_hsa051460.60762544
100Toxoplasmosis_Homo sapiens_hsa051450.59161893
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.58926335
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58861202
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.58318667
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58242563
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56541418
106Rheumatoid arthritis_Homo sapiens_hsa053230.55898682
107Pancreatic secretion_Homo sapiens_hsa049720.55355743
108Lysosome_Homo sapiens_hsa041420.54965577
109Salmonella infection_Homo sapiens_hsa051320.54601381
110Alcoholism_Homo sapiens_hsa050340.54572018
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.53994639
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53289857
113Phagosome_Homo sapiens_hsa041450.52406731
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52082617
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50919414
116Huntingtons disease_Homo sapiens_hsa050160.50712904
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50577255
118Insulin signaling pathway_Homo sapiens_hsa049100.50057547
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.49370741
120VEGF signaling pathway_Homo sapiens_hsa043700.49144063
121Prolactin signaling pathway_Homo sapiens_hsa049170.48036772
122Inositol phosphate metabolism_Homo sapiens_hsa005620.47725564
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47305941
124Parkinsons disease_Homo sapiens_hsa050120.44540666
125Wnt signaling pathway_Homo sapiens_hsa043100.44422400
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44176887
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41233792
128Rap1 signaling pathway_Homo sapiens_hsa040150.38788969
129Prion diseases_Homo sapiens_hsa050200.37894751
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36754224
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36327627
132mTOR signaling pathway_Homo sapiens_hsa041500.35245386
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33423104
134Endocytosis_Homo sapiens_hsa041440.31006136
135Chemokine signaling pathway_Homo sapiens_hsa040620.26512837

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