

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation by symbiont of host defense response (GO:0052509) | 4.37810891 |
| 2 | modulation by symbiont of host defense response (GO:0052031) | 4.37810891 |
| 3 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.37810891 |
| 4 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.37810891 |
| 5 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.37810891 |
| 6 | modulation by symbiont of host immune response (GO:0052553) | 4.37810891 |
| 7 | cell adhesion mediated by integrin (GO:0033627) | 4.22005241 |
| 8 | response to peptidoglycan (GO:0032494) | 3.82512237 |
| 9 | endodermal cell differentiation (GO:0035987) | 3.58987590 |
| 10 | positive regulation of p38MAPK cascade (GO:1900745) | 3.57878169 |
| 11 | detection of other organism (GO:0098543) | 3.57171541 |
| 12 | apoptotic cell clearance (GO:0043277) | 3.50164869 |
| 13 | detection of external biotic stimulus (GO:0098581) | 3.42959002 |
| 14 | response to muramyl dipeptide (GO:0032495) | 3.38510811 |
| 15 | negative regulation of cell killing (GO:0031342) | 3.38407926 |
| 16 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.38407926 |
| 17 | protein heterotrimerization (GO:0070208) | 3.34594207 |
| 18 | regulation of mast cell degranulation (GO:0043304) | 3.32699218 |
| 19 | detection of bacterium (GO:0016045) | 3.30869359 |
| 20 | protein localization to endosome (GO:0036010) | 3.29683968 |
| 21 | macrophage activation (GO:0042116) | 3.29653197 |
| 22 | macrophage activation involved in immune response (GO:0002281) | 3.27935418 |
| 23 | regulation of macrophage cytokine production (GO:0010935) | 3.27885025 |
| 24 | substrate-dependent cell migration (GO:0006929) | 3.25878693 |
| 25 | microglial cell activation (GO:0001774) | 3.16876797 |
| 26 | detection of biotic stimulus (GO:0009595) | 3.16633712 |
| 27 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.15419071 |
| 28 | positive regulation of macrophage cytokine production (GO:0060907) | 3.14299480 |
| 29 | regulation of leukocyte degranulation (GO:0043300) | 3.10618899 |
| 30 | wound healing, spreading of epidermal cells (GO:0035313) | 3.09939268 |
| 31 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.09896110 |
| 32 | cortical actin cytoskeleton organization (GO:0030866) | 3.06197518 |
| 33 | mannose metabolic process (GO:0006013) | 3.04337483 |
| 34 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.04044269 |
| 35 | T-helper 1 type immune response (GO:0042088) | 3.01684193 |
| 36 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.01497198 |
| 37 | response to host immune response (GO:0052572) | 3.00969331 |
| 38 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.00969331 |
| 39 | skin morphogenesis (GO:0043589) | 2.98945918 |
| 40 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.98918369 |
| 41 | negative regulation of interleukin-12 production (GO:0032695) | 2.98529361 |
| 42 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 2.98238808 |
| 43 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 2.94257599 |
| 44 | response to host (GO:0075136) | 2.94257599 |
| 45 | response to host defenses (GO:0052200) | 2.94257599 |
| 46 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.92990757 |
| 47 | negative regulation of interleukin-6 production (GO:0032715) | 2.89824990 |
| 48 | low-density lipoprotein particle clearance (GO:0034383) | 2.89473977 |
| 49 | negative regulation of fatty acid transport (GO:2000192) | 2.87767811 |
| 50 | myeloid cell activation involved in immune response (GO:0002275) | 2.86365693 |
| 51 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.86031759 |
| 52 | germinal center formation (GO:0002467) | 2.85972362 |
| 53 | neutrophil activation involved in immune response (GO:0002283) | 2.85093780 |
| 54 | collagen fibril organization (GO:0030199) | 2.84776276 |
| 55 | regulation of mast cell activation (GO:0033003) | 2.84277291 |
| 56 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.84235655 |
| 57 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.83990034 |
| 58 | tooth mineralization (GO:0034505) | 2.83124433 |
| 59 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.82883946 |
| 60 | positive regulation of mast cell activation (GO:0033005) | 2.80936865 |
| 61 | stress fiber assembly (GO:0043149) | 2.80281541 |
| 62 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.80255459 |
| 63 | axon extension involved in axon guidance (GO:0048846) | 2.80255459 |
| 64 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.78479810 |
| 65 | regulation of p38MAPK cascade (GO:1900744) | 2.77850381 |
| 66 | neutrophil activation (GO:0042119) | 2.76679087 |
| 67 | regulation of integrin activation (GO:0033623) | 2.74085069 |
| 68 | positive regulation of mast cell degranulation (GO:0043306) | 2.74003693 |
| 69 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.74003693 |
| 70 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 2.73706857 |
| 71 | negative regulation of interleukin-1 production (GO:0032692) | 2.69644818 |
| 72 | cortical cytoskeleton organization (GO:0030865) | 2.69151438 |
| 73 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.68994912 |
| 74 | negative regulation of interleukin-8 production (GO:0032717) | 2.68342451 |
| 75 | respiratory burst (GO:0045730) | 2.68309698 |
| 76 | positive regulation of interferon-alpha production (GO:0032727) | 2.67921999 |
| 77 | response to laminar fluid shear stress (GO:0034616) | 2.66970386 |
| 78 | positive regulation of fibroblast migration (GO:0010763) | 2.65071376 |
| 79 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition | 2.64891729 |
| 80 | positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) | 2.62985883 |
| 81 | amino sugar catabolic process (GO:0046348) | 2.62675533 |
| 82 | regulation of interferon-alpha production (GO:0032647) | 2.62527200 |
| 83 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.61948276 |
| 84 | negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556) | 2.60279144 |
| 85 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.60152585 |
| 86 | positive regulation of leukocyte degranulation (GO:0043302) | 2.60030554 |
| 87 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.59637082 |
| 88 | regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) | 2.59061979 |
| 89 | virion attachment to host cell (GO:0019062) | 2.57010505 |
| 90 | adhesion of symbiont to host cell (GO:0044650) | 2.57010505 |
| 91 | defense response to protozoan (GO:0042832) | 2.56534574 |
| 92 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 2.56101064 |
| 93 | negative regulation of tumor necrosis factor production (GO:0032720) | 2.55656474 |
| 94 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.55132839 |
| 95 | regulation of regulated secretory pathway (GO:1903305) | 2.54833673 |
| 96 | cellular response to interferon-alpha (GO:0035457) | 2.54554975 |
| 97 | regulation of early endosome to late endosome transport (GO:2000641) | 2.54522970 |
| 98 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 2.53881769 |
| 99 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.53141688 |
| 100 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 2.53086878 |
| 101 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.52742216 |
| 102 | response to fluid shear stress (GO:0034405) | 2.52452848 |
| 103 | regulation of tumor necrosis factor production (GO:0032680) | 2.51633220 |
| 104 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.51596604 |
| 105 | regulation of interleukin-6 production (GO:0032675) | 2.51124069 |
| 106 | neutrophil chemotaxis (GO:0030593) | 2.50995990 |
| 107 | regulation of chemokine biosynthetic process (GO:0045073) | 2.50739455 |
| 108 | positive regulation of tumor necrosis factor production (GO:0032760) | 2.50163914 |
| 109 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.49336777 |
| 110 | pinocytosis (GO:0006907) | 2.49019191 |
| 111 | plasma membrane repair (GO:0001778) | 2.48896367 |
| 112 | response to protozoan (GO:0001562) | 2.48425104 |
| 113 | regulation of type 2 immune response (GO:0002828) | 2.47493385 |
| 114 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.46165633 |
| 115 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 2.45514487 |
| 116 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 2.44382250 |
| 117 | I-kappaB phosphorylation (GO:0007252) | 2.44095924 |
| 118 | negative regulation of granulocyte differentiation (GO:0030853) | 2.43641058 |
| 119 | neutrophil migration (GO:1990266) | 2.43588080 |
| 120 | regulation of antigen processing and presentation (GO:0002577) | 2.43551988 |
| 121 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.42839684 |
| 122 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 2.42298988 |
| 123 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 2.42298988 |
| 124 | chondrocyte proliferation (GO:0035988) | 2.41681073 |
| 125 | regulation of mononuclear cell migration (GO:0071675) | 2.37291194 |
| 126 | collagen metabolic process (GO:0032963) | 2.36561079 |
| 127 | growth hormone receptor signaling pathway (GO:0060396) | 2.36322088 |
| 128 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.35508613 |
| 129 | regulation of T-helper 1 cell differentiation (GO:0045625) | 2.34945143 |
| 130 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.34209700 |
| 131 | wound healing, spreading of cells (GO:0044319) | 2.33817571 |
| 132 | collagen catabolic process (GO:0030574) | 2.33788594 |
| 133 | detection of molecule of bacterial origin (GO:0032490) | 2.33465887 |
| 134 | semaphorin-plexin signaling pathway (GO:0071526) | 2.32334162 |
| 135 | regulation of podosome assembly (GO:0071801) | 2.32017635 |
| 136 | antigen processing and presentation of endogenous antigen (GO:0019883) | 2.29979242 |
| 137 | modulation by symbiont of host cellular process (GO:0044068) | 2.29887564 |
| 138 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.27241814 |
| 139 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.26863459 |
| 140 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.26526426 |
| 141 | establishment of endothelial barrier (GO:0061028) | 2.23440835 |
| 142 | regulation of macrophage chemotaxis (GO:0010758) | 2.22809326 |
| 143 | integrin-mediated signaling pathway (GO:0007229) | 2.22766448 |
| 144 | response to nerve growth factor (GO:1990089) | 2.22400206 |
| 145 | cellular response to nerve growth factor stimulus (GO:1990090) | 2.22400206 |
| 146 | endocytic recycling (GO:0032456) | 2.21726618 |
| 147 | multicellular organismal macromolecule metabolic process (GO:0044259) | 2.20233242 |
| 148 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.19135089 |
| 149 | immunoglobulin mediated immune response (GO:0016064) | 2.19086358 |
| 150 | positive regulation of osteoblast proliferation (GO:0033690) | 2.18632195 |
| 151 | vascular endothelial growth factor signaling pathway (GO:0038084) | 2.17848106 |
| 152 | mRNA transcription (GO:0009299) | 2.17421162 |
| 153 | granulocyte activation (GO:0036230) | 2.17253323 |
| 154 | cellular extravasation (GO:0045123) | 2.17118580 |
| 155 | barbed-end actin filament capping (GO:0051016) | 2.16781388 |
| 156 | adhesion of symbiont to host (GO:0044406) | 2.15982015 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.83488643 |
| 2 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.51225084 |
| 3 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 3.49970423 |
| 4 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.18176062 |
| 5 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.91901171 |
| 6 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.56449081 |
| 7 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 2.45788050 |
| 8 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.45367504 |
| 9 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.43440851 |
| 10 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.42710560 |
| 11 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.40249921 |
| 12 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.39889095 |
| 13 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 2.35842082 |
| 14 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.33900796 |
| 15 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.25990437 |
| 16 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.24780102 |
| 17 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.19899926 |
| 18 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.19295160 |
| 19 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.18335785 |
| 20 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.15532964 |
| 21 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.12158076 |
| 22 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.02694372 |
| 23 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.02207136 |
| 24 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.92152964 |
| 25 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.86273686 |
| 26 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.86115703 |
| 27 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.81758905 |
| 28 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.75446787 |
| 29 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.75279958 |
| 30 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.73833216 |
| 31 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.71586972 |
| 32 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.68188799 |
| 33 | SPI1_23127762_ChIP-Seq_K562_Human | 1.67144155 |
| 34 | * IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.66319043 |
| 35 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.65610142 |
| 36 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.64893580 |
| 37 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.59682597 |
| 38 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.59621611 |
| 39 | KDM2B_26808549_Chip-Seq_K562_Human | 1.59375396 |
| 40 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.56486695 |
| 41 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.54629928 |
| 42 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.52625472 |
| 43 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.51095823 |
| 44 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.50913774 |
| 45 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.49587177 |
| 46 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.49052344 |
| 47 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.45514368 |
| 48 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.45326860 |
| 49 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.44759419 |
| 50 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.43818032 |
| 51 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.42155342 |
| 52 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.42036897 |
| 53 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 1.40920897 |
| 54 | MAF_26560356_Chip-Seq_TH1_Human | 1.40613012 |
| 55 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.37233054 |
| 56 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.34686086 |
| 57 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.34509700 |
| 58 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.34140953 |
| 59 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.32927370 |
| 60 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.32808782 |
| 61 | MYC_22102868_ChIP-Seq_BL_Human | 1.31567447 |
| 62 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.31229229 |
| 63 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.28502337 |
| 64 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28239975 |
| 65 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.27209008 |
| 66 | CJUN_26792858_Chip-Seq_BT549_Human | 1.26227707 |
| 67 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.25565155 |
| 68 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.25323143 |
| 69 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24882885 |
| 70 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.22614498 |
| 71 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.21118563 |
| 72 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.20969995 |
| 73 | ATF3_27146783_Chip-Seq_COLON_Human | 1.20239839 |
| 74 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.19580700 |
| 75 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.19204394 |
| 76 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.19007332 |
| 77 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.18681835 |
| 78 | TP53_16413492_ChIP-PET_HCT116_Human | 1.18573061 |
| 79 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.18419018 |
| 80 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.18003784 |
| 81 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.17318961 |
| 82 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.16455886 |
| 83 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.15893285 |
| 84 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.15446624 |
| 85 | UTX_26944678_Chip-Seq_JUKART_Human | 1.15300814 |
| 86 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.14432576 |
| 87 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.13237995 |
| 88 | * BRD4_25478319_ChIP-Seq_HGPS_Human | 1.13154413 |
| 89 | GATA1_19941826_ChIP-Seq_K562_Human | 1.12459413 |
| 90 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.10912522 |
| 91 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.10912522 |
| 92 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.10754168 |
| 93 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.09866338 |
| 94 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.09844860 |
| 95 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.09667562 |
| 96 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.08140588 |
| 97 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.07502522 |
| 98 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.07409602 |
| 99 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.07371788 |
| 100 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.07148582 |
| 101 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.06976783 |
| 102 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.05841452 |
| 103 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.05690826 |
| 104 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.05688767 |
| 105 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.05221233 |
| 106 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.04982360 |
| 107 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.04863732 |
| 108 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.03687206 |
| 109 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.03312115 |
| 110 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.02044023 |
| 111 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.01657970 |
| 112 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.01551848 |
| 113 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.00745942 |
| 114 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.00667588 |
| 115 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.00667588 |
| 116 | * PU_27001747_Chip-Seq_BMDM_Mouse | 1.00282003 |
| 117 | MAF_26560356_Chip-Seq_TH2_Human | 0.98890369 |
| 118 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.98651119 |
| 119 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.98600682 |
| 120 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.98054493 |
| 121 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.97568049 |
| 122 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.97114518 |
| 123 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.96405745 |
| 124 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96048570 |
| 125 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.95915779 |
| 126 | * NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.95169436 |
| 127 | * DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.95138323 |
| 128 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.95112845 |
| 129 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 0.92634407 |
| 130 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.91736081 |
| 131 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.91048511 |
| 132 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.90504856 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 5.40913708 |
| 2 | MP0003303_peritoneal_inflammation | 4.09735689 |
| 3 | MP0003705_abnormal_hypodermis_morpholog | 3.41512191 |
| 4 | MP0004510_myositis | 2.71326165 |
| 5 | MP0005623_abnormal_meninges_morphology | 2.64998141 |
| 6 | MP0005275_abnormal_skin_tensile | 2.64128739 |
| 7 | MP0001958_emphysema | 2.56329394 |
| 8 | MP0003279_aneurysm | 2.55205829 |
| 9 | MP0009278_abnormal_bone_marrow | 2.50042033 |
| 10 | MP0003436_decreased_susceptibility_to | 2.44519148 |
| 11 | MP0003566_abnormal_cell_adhesion | 2.43144559 |
| 12 | MP0009840_abnormal_foam_cell | 2.41686128 |
| 13 | MP0003300_gastrointestinal_ulcer | 2.35287146 |
| 14 | MP0005503_abnormal_tendon_morphology | 2.31677384 |
| 15 | MP0003091_abnormal_cell_migration | 2.30809869 |
| 16 | MP0010352_gastrointestinal_tract_polyps | 2.16585576 |
| 17 | MP0002254_reproductive_system_inflammat | 2.12709944 |
| 18 | MP0005058_abnormal_lysosome_morphology | 1.99706474 |
| 19 | MP0003191_abnormal_cellular_cholesterol | 1.93586024 |
| 20 | MP0001533_abnormal_skeleton_physiology | 1.92677781 |
| 21 | MP0003448_altered_tumor_morphology | 1.88931964 |
| 22 | MP0003075_altered_response_to | 1.88323396 |
| 23 | MP0003172_abnormal_lysosome_physiology | 1.85993115 |
| 24 | MP0004858_abnormal_nervous_system | 1.80114142 |
| 25 | MP0002419_abnormal_innate_immunity | 1.74566419 |
| 26 | * MP0005023_abnormal_wound_healing | 1.74161225 |
| 27 | MP0002877_abnormal_melanocyte_morpholog | 1.73672176 |
| 28 | MP0005257_abnormal_intraocular_pressure | 1.72935826 |
| 29 | MP0000733_abnormal_muscle_development | 1.72455079 |
| 30 | MP0000569_abnormal_digit_pigmentation | 1.66506686 |
| 31 | MP0000343_altered_response_to | 1.64177166 |
| 32 | MP0009764_decreased_sensitivity_to | 1.63860773 |
| 33 | MP0009785_altered_susceptibility_to | 1.60760003 |
| 34 | MP0002998_abnormal_bone_remodeling | 1.53849808 |
| 35 | MP0005451_abnormal_body_composition | 1.53758710 |
| 36 | MP0005000_abnormal_immune_tolerance | 1.50973388 |
| 37 | MP0004947_skin_inflammation | 1.50720927 |
| 38 | * MP0005076_abnormal_cell_differentiation | 1.50034103 |
| 39 | MP0001790_abnormal_immune_system | 1.47468833 |
| 40 | MP0005387_immune_system_phenotype | 1.47468833 |
| 41 | MP0003045_fibrosis | 1.46062450 |
| 42 | MP0000685_abnormal_immune_system | 1.44921826 |
| 43 | MP0001348_abnormal_lacrimal_gland | 1.42831124 |
| 44 | MP0005167_abnormal_blood-brain_barrier | 1.40485938 |
| 45 | MP0006082_CNS_inflammation | 1.39920308 |
| 46 | MP0005390_skeleton_phenotype | 1.37595688 |
| 47 | MP0004272_abnormal_basement_membrane | 1.34876769 |
| 48 | MP0005164_abnormal_response_to | 1.33181150 |
| 49 | MP0000767_abnormal_smooth_muscle | 1.32622784 |
| 50 | MP0005397_hematopoietic_system_phenotyp | 1.32291778 |
| 51 | MP0001545_abnormal_hematopoietic_system | 1.32291778 |
| 52 | MP0000750_abnormal_muscle_regeneration | 1.32287607 |
| 53 | MP0004859_abnormal_synaptic_plasticity | 1.31611937 |
| 54 | MP0001853_heart_inflammation | 1.31130620 |
| 55 | MP0000858_altered_metastatic_potential | 1.29282369 |
| 56 | MP0000604_amyloidosis | 1.28149056 |
| 57 | MP0002452_abnormal_antigen_presenting | 1.26582693 |
| 58 | MP0002933_joint_inflammation | 1.25629408 |
| 59 | MP0002148_abnormal_hypersensitivity_rea | 1.24745587 |
| 60 | MP0005671_abnormal_response_to | 1.24705683 |
| 61 | MP0005464_abnormal_platelet_physiology | 1.24054440 |
| 62 | MP0008469_abnormal_protein_level | 1.23574350 |
| 63 | MP0001835_abnormal_antigen_presentation | 1.23550269 |
| 64 | MP0005025_abnormal_response_to | 1.23000266 |
| 65 | MP0008004_abnormal_stomach_pH | 1.21248643 |
| 66 | MP0005595_abnormal_vascular_smooth | 1.18790654 |
| 67 | MP0010307_abnormal_tumor_latency | 1.17754795 |
| 68 | MP0003453_abnormal_keratinocyte_physiol | 1.16648227 |
| 69 | MP0008260_abnormal_autophagy | 1.10475462 |
| 70 | MP0005508_abnormal_skeleton_morphology | 1.10415077 |
| 71 | MP0003828_pulmonary_edema | 1.09188751 |
| 72 | MP0002295_abnormal_pulmonary_circulatio | 1.08023598 |
| 73 | MP0002405_respiratory_system_inflammati | 1.06908459 |
| 74 | MP0002060_abnormal_skin_morphology | 1.06505923 |
| 75 | MP0001800_abnormal_humoral_immune | 1.02006419 |
| 76 | MP0002723_abnormal_immune_serum | 1.01641405 |
| 77 | MP0004808_abnormal_hematopoietic_stem | 0.98940704 |
| 78 | MP0001819_abnormal_immune_cell | 0.98289172 |
| 79 | MP0002420_abnormal_adaptive_immunity | 0.96850356 |
| 80 | MP0001542_abnormal_bone_strength | 0.94598141 |
| 81 | MP0006054_spinal_hemorrhage | 0.93759359 |
| 82 | MP0003183_abnormal_peptide_metabolism | 0.91642088 |
| 83 | MP0005165_increased_susceptibility_to | 0.90125033 |
| 84 | MP0003724_increased_susceptibility_to | 0.88227223 |
| 85 | MP0002138_abnormal_hepatobiliary_system | 0.87090538 |
| 86 | MP0005310_abnormal_salivary_gland | 0.84954847 |
| 87 | MP0000751_myopathy | 0.84932842 |
| 88 | MP0003795_abnormal_bone_structure | 0.84758533 |
| 89 | MP0005166_decreased_susceptibility_to | 0.84507753 |
| 90 | MP0001845_abnormal_inflammatory_respons | 0.84029471 |
| 91 | MP0003329_amyloid_beta_deposits | 0.83075832 |
| 92 | MP0004883_abnormal_blood_vessel | 0.82937444 |
| 93 | MP0001851_eye_inflammation | 0.82919392 |
| 94 | MP0002896_abnormal_bone_mineralization | 0.81259820 |
| 95 | MP0000249_abnormal_blood_vessel | 0.80899950 |
| 96 | MP0005197_abnormal_uvea_morphology | 0.79328198 |
| 97 | MP0001243_abnormal_dermal_layer | 0.79315970 |
| 98 | MP0002133_abnormal_respiratory_system | 0.78268188 |
| 99 | MP0005388_respiratory_system_phenotype | 0.78268188 |
| 100 | MP0001849_ear_inflammation | 0.78172737 |
| 101 | MP0009384_cardiac_valve_regurgitation | 0.78077078 |
| 102 | MP0001299_abnormal_eye_distance/ | 0.76364782 |
| 103 | MP0010155_abnormal_intestine_physiology | 0.75829479 |
| 104 | MP0002168_other_aberrant_phenotype | 0.75655030 |
| 105 | MP0001663_abnormal_digestive_system | 0.73507290 |
| 106 | MP0001915_intracranial_hemorrhage | 0.71243714 |
| 107 | MP0009763_increased_sensitivity_to | 0.70309472 |
| 108 | MP0009333_abnormal_splenocyte_physiolog | 0.70011023 |
| 109 | MP0004087_abnormal_muscle_fiber | 0.68148152 |
| 110 | MP0002398_abnormal_bone_marrow | 0.66789588 |
| 111 | MP0001614_abnormal_blood_vessel | 0.66771565 |
| 112 | MP0002108_abnormal_muscle_morphology | 0.66350941 |
| 113 | MP0003806_abnormal_nucleotide_metabolis | 0.65872924 |
| 114 | MP0002429_abnormal_blood_cell | 0.65577092 |
| 115 | MP0002089_abnormal_postnatal_growth/wei | 0.64342625 |
| 116 | MP0002925_abnormal_cardiovascular_devel | 0.63858035 |
| 117 | MP0004130_abnormal_muscle_cell | 0.62467288 |
| 118 | MP0000689_abnormal_spleen_morphology | 0.62364252 |
| 119 | MP0002113_abnormal_skeleton_development | 0.61906941 |
| 120 | MP0002128_abnormal_blood_circulation | 0.61387077 |
| 121 | MP0000013_abnormal_adipose_tissue | 0.61361020 |
| 122 | MP0001501_abnormal_sleep_pattern | 0.61134019 |
| 123 | MP0003690_abnormal_glial_cell | 0.60362267 |
| 124 | MP0000716_abnormal_immune_system | 0.60360016 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Premature rupture of membranes (HP:0001788) | 5.59767407 |
| 2 | Protrusio acetabuli (HP:0003179) | 5.35740890 |
| 3 | Abnormality of glycolipid metabolism (HP:0010969) | 4.79836508 |
| 4 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.79836508 |
| 5 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.79836508 |
| 6 | Peritonitis (HP:0002586) | 4.24302456 |
| 7 | Cerebral aneurysm (HP:0004944) | 3.84528600 |
| 8 | Systemic lupus erythematosus (HP:0002725) | 3.65628582 |
| 9 | Shallow orbits (HP:0000586) | 3.60436917 |
| 10 | Vertebral compression fractures (HP:0002953) | 3.35161937 |
| 11 | Vacuolated lymphocytes (HP:0001922) | 3.28076590 |
| 12 | Aortic dissection (HP:0002647) | 3.22598672 |
| 13 | Recurrent abscess formation (HP:0002722) | 3.17729896 |
| 14 | Dilatation of the ascending aorta (HP:0005111) | 3.17282095 |
| 15 | Cervical subluxation (HP:0003308) | 3.16964774 |
| 16 | Ankle contracture (HP:0006466) | 3.14774803 |
| 17 | Eczematoid dermatitis (HP:0000976) | 3.14685858 |
| 18 | Amyloidosis (HP:0011034) | 3.09099370 |
| 19 | Loss of speech (HP:0002371) | 2.92233244 |
| 20 | Genu recurvatum (HP:0002816) | 2.91304480 |
| 21 | Atrophic scars (HP:0001075) | 2.78281596 |
| 22 | Mitral valve prolapse (HP:0001634) | 2.78184231 |
| 23 | Spontaneous hematomas (HP:0007420) | 2.76373749 |
| 24 | Increased cerebral lipofuscin (HP:0011813) | 2.70488022 |
| 25 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.66214895 |
| 26 | Osteolytic defects of the hand bones (HP:0009699) | 2.66214895 |
| 27 | Bladder diverticulum (HP:0000015) | 2.66203742 |
| 28 | Ulnar bowing (HP:0003031) | 2.64525776 |
| 29 | Distal upper limb amyotrophy (HP:0007149) | 2.61193709 |
| 30 | Upper limb amyotrophy (HP:0009129) | 2.61193709 |
| 31 | Recurrent bacterial skin infections (HP:0005406) | 2.58951457 |
| 32 | Fragile skin (HP:0001030) | 2.56453685 |
| 33 | Increased density of long bones (HP:0006392) | 2.54004611 |
| 34 | Increased connective tissue (HP:0009025) | 2.53905224 |
| 35 | Aortic aneurysm (HP:0004942) | 2.53539271 |
| 36 | Soft skin (HP:0000977) | 2.50164270 |
| 37 | Distal lower limb amyotrophy (HP:0008944) | 2.47222655 |
| 38 | Wormian bones (HP:0002645) | 2.43558222 |
| 39 | Broad metatarsal (HP:0001783) | 2.41198180 |
| 40 | Myositis (HP:0100614) | 2.39481857 |
| 41 | Orchitis (HP:0100796) | 2.39459262 |
| 42 | Recurrent skin infections (HP:0001581) | 2.39376010 |
| 43 | Abnormality of macrophages (HP:0004311) | 2.37014669 |
| 44 | Joint stiffness (HP:0001387) | 2.35878578 |
| 45 | Hematochezia (HP:0002573) | 2.35312653 |
| 46 | Blue sclerae (HP:0000592) | 2.33749803 |
| 47 | Disinhibition (HP:0000734) | 2.31014167 |
| 48 | Mutism (HP:0002300) | 2.29350230 |
| 49 | Vascular tortuosity (HP:0004948) | 2.28919285 |
| 50 | Hemoptysis (HP:0002105) | 2.27933438 |
| 51 | Lower limb amyotrophy (HP:0007210) | 2.25855958 |
| 52 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.24754095 |
| 53 | Recurrent fungal infections (HP:0002841) | 2.24188931 |
| 54 | Emphysema (HP:0002097) | 2.22640631 |
| 55 | Chronic obstructive pulmonary disease (HP:0006510) | 2.21119970 |
| 56 | Abnormality of the peritoneum (HP:0002585) | 2.20421233 |
| 57 | Increased serum ferritin (HP:0003281) | 2.18611834 |
| 58 | Striae distensae (HP:0001065) | 2.18152581 |
| 59 | Type 1 muscle fiber predominance (HP:0003803) | 2.16979723 |
| 60 | Slender build (HP:0001533) | 2.16740660 |
| 61 | Arterial tortuosity (HP:0005116) | 2.16332153 |
| 62 | Asymmetric septal hypertrophy (HP:0001670) | 2.16088563 |
| 63 | Cellulitis (HP:0100658) | 2.15045863 |
| 64 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.13690929 |
| 65 | Gastrointestinal infarctions (HP:0005244) | 2.10537714 |
| 66 | Pulmonary infiltrates (HP:0002113) | 2.09797091 |
| 67 | Abnormality of dentin (HP:0010299) | 2.09772381 |
| 68 | Nuclear cataract (HP:0100018) | 2.09508358 |
| 69 | Hyperextensible skin (HP:0000974) | 2.08771478 |
| 70 | Spinal rigidity (HP:0003306) | 2.08685809 |
| 71 | Dysostosis multiplex (HP:0000943) | 2.05043850 |
| 72 | Neurofibrillary tangles (HP:0002185) | 2.04617579 |
| 73 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.04016552 |
| 74 | Neonatal short-limb short stature (HP:0008921) | 2.03699894 |
| 75 | Absent frontal sinuses (HP:0002688) | 2.02469767 |
| 76 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.02278298 |
| 77 | Recurrent cutaneous fungal infections (HP:0011370) | 2.02278298 |
| 78 | Myocardial infarction (HP:0001658) | 2.02193572 |
| 79 | Abnormality of complement system (HP:0005339) | 2.01525343 |
| 80 | Mediastinal lymphadenopathy (HP:0100721) | 2.01284883 |
| 81 | Episodic fever (HP:0001954) | 1.99992443 |
| 82 | Ovoid vertebral bodies (HP:0003300) | 1.99899568 |
| 83 | Aneurysm (HP:0002617) | 1.98443324 |
| 84 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.98437881 |
| 85 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.98319748 |
| 86 | Urticaria (HP:0001025) | 1.97123384 |
| 87 | Difficulty climbing stairs (HP:0003551) | 1.95281228 |
| 88 | Hand muscle atrophy (HP:0009130) | 1.94992585 |
| 89 | Keratoconjunctivitis sicca (HP:0001097) | 1.94001487 |
| 90 | Biconcave vertebral bodies (HP:0004586) | 1.92856202 |
| 91 | Stomatitis (HP:0010280) | 1.92712034 |
| 92 | Interstitial pulmonary disease (HP:0006530) | 1.92655218 |
| 93 | Bowel diverticulosis (HP:0005222) | 1.92581483 |
| 94 | Wrist flexion contracture (HP:0001239) | 1.92184756 |
| 95 | Distal lower limb muscle weakness (HP:0009053) | 1.91273204 |
| 96 | Meningitis (HP:0001287) | 1.90913123 |
| 97 | Vasculitis (HP:0002633) | 1.90462261 |
| 98 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.89599525 |
| 99 | Mucopolysacchariduria (HP:0008155) | 1.89599525 |
| 100 | Syringomyelia (HP:0003396) | 1.89198093 |
| 101 | Spinal cord lesions (HP:0100561) | 1.89198093 |
| 102 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.88487380 |
| 103 | Polycythemia (HP:0001901) | 1.88377611 |
| 104 | Camptodactyly of toe (HP:0001836) | 1.88235876 |
| 105 | Axonal loss (HP:0003447) | 1.88027500 |
| 106 | Purpura (HP:0000979) | 1.87984481 |
| 107 | Persistence of primary teeth (HP:0006335) | 1.87782640 |
| 108 | Progressive neurologic deterioration (HP:0002344) | 1.85843309 |
| 109 | Deviation of the hallux (HP:0010051) | 1.85788705 |
| 110 | Scapular winging (HP:0003691) | 1.85519110 |
| 111 | Hallux valgus (HP:0001822) | 1.85513796 |
| 112 | Glomerulonephritis (HP:0000099) | 1.85131138 |
| 113 | Increased variability in muscle fiber diameter (HP:0003557) | 1.84518835 |
| 114 | Arterial thrombosis (HP:0004420) | 1.84458070 |
| 115 | Bowing of the arm (HP:0006488) | 1.84434013 |
| 116 | Bowed forearm bones (HP:0003956) | 1.84434013 |
| 117 | Abnormality of the nasal mucosa (HP:0000433) | 1.84173141 |
| 118 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.83248894 |
| 119 | Frequent falls (HP:0002359) | 1.83169144 |
| 120 | Achilles tendon contracture (HP:0001771) | 1.82850724 |
| 121 | Increased IgE level (HP:0003212) | 1.82404616 |
| 122 | Optic neuritis (HP:0100653) | 1.82191167 |
| 123 | Retrobulbar optic neuritis (HP:0100654) | 1.82191167 |
| 124 | Gingivitis (HP:0000230) | 1.81220069 |
| 125 | Elbow flexion contracture (HP:0002987) | 1.79634415 |
| 126 | Restrictive lung disease (HP:0002091) | 1.77864142 |
| 127 | Petechiae (HP:0000967) | 1.77165723 |
| 128 | Radial bowing (HP:0002986) | 1.77098184 |
| 129 | Thin bony cortex (HP:0002753) | 1.76483005 |
| 130 | Spondylolisthesis (HP:0003302) | 1.76210259 |
| 131 | Abnormality of skeletal muscle fiber size (HP:0012084) | 1.75646592 |
| 132 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.74862943 |
| 133 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.74862943 |
| 134 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.74862943 |
| 135 | Flexion contracture of toe (HP:0005830) | 1.72818656 |
| 136 | Joint contractures involving the joints of the feet (HP:0100492) | 1.72818656 |
| 137 | Abnormality of the acetabulum (HP:0003170) | 1.72786651 |
| 138 | Mitral regurgitation (HP:0001653) | 1.71491947 |
| 139 | Tetraparesis (HP:0002273) | 1.71046343 |
| 140 | Follicular hyperkeratosis (HP:0007502) | 1.69763352 |
| 141 | Round ear (HP:0100830) | 1.68301028 |
| 142 | Disproportionate tall stature (HP:0001519) | 1.68109635 |
| 143 | Obstructive lung disease (HP:0006536) | 1.66427427 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 4.36342462 |
| 2 | PKN2 | 2.80988122 |
| 3 | ERN1 | 2.74005809 |
| 4 | DDR2 | 2.73581184 |
| 5 | PRPF4B | 2.66680533 |
| 6 | TTN | 2.64311805 |
| 7 | BMX | 2.43251122 |
| 8 | EPHB1 | 2.39753050 |
| 9 | TBK1 | 2.37814926 |
| 10 | RIPK4 | 2.19871131 |
| 11 | RIPK1 | 2.16195441 |
| 12 | PDGFRA | 1.86535837 |
| 13 | MOS | 1.74409392 |
| 14 | TAOK2 | 1.66277343 |
| 15 | MAP3K9 | 1.64654271 |
| 16 | ZAP70 | 1.63956367 |
| 17 | PTK6 | 1.63921043 |
| 18 | LRRK2 | 1.63908243 |
| 19 | ALK | 1.58960916 |
| 20 | CDC42BPA | 1.56723401 |
| 21 | BLK | 1.53557900 |
| 22 | MAP3K10 | 1.53474990 |
| 23 | FGR | 1.50888102 |
| 24 | MAP3K13 | 1.50861089 |
| 25 | GRK7 | 1.49915414 |
| 26 | PRKD2 | 1.49873515 |
| 27 | MAP3K14 | 1.46185536 |
| 28 | JAK1 | 1.44473417 |
| 29 | PAK4 | 1.44332412 |
| 30 | CAMKK1 | 1.42689820 |
| 31 | KIT | 1.39407958 |
| 32 | SIK2 | 1.37808692 |
| 33 | EEF2K | 1.34647042 |
| 34 | KSR2 | 1.27613258 |
| 35 | TYK2 | 1.27277156 |
| 36 | PAK6 | 1.26467122 |
| 37 | MAPK7 | 1.25750364 |
| 38 | SIK1 | 1.25282515 |
| 39 | PIM2 | 1.23659291 |
| 40 | MYLK | 1.20519966 |
| 41 | TAOK1 | 1.18442569 |
| 42 | LATS2 | 1.18420364 |
| 43 | NEK9 | 1.17001208 |
| 44 | PTK2B | 1.14930707 |
| 45 | DMPK | 1.14785820 |
| 46 | PTK2 | 1.13015431 |
| 47 | IRAK1 | 1.12565553 |
| 48 | TGFBR2 | 1.12437883 |
| 49 | CSK | 1.11738297 |
| 50 | FES | 1.11292334 |
| 51 | MARK2 | 1.11267818 |
| 52 | IRAK2 | 1.10824152 |
| 53 | TRPM7 | 1.09755281 |
| 54 | STK10 | 1.04381572 |
| 55 | IKBKB | 1.04327550 |
| 56 | CAMK1D | 1.04149682 |
| 57 | CAMK1G | 1.00418528 |
| 58 | MAP4K1 | 0.99748836 |
| 59 | HCK | 0.98998966 |
| 60 | JAK3 | 0.98618399 |
| 61 | DAPK3 | 0.98328938 |
| 62 | IKBKE | 0.97429892 |
| 63 | MAP3K6 | 0.97243566 |
| 64 | PAK2 | 0.96224722 |
| 65 | TNK2 | 0.95015404 |
| 66 | PIK3CG | 0.94557851 |
| 67 | MAPK12 | 0.93684072 |
| 68 | NTRK1 | 0.91740374 |
| 69 | SYK | 0.90973876 |
| 70 | PDGFRB | 0.90482046 |
| 71 | NME2 | 0.89815989 |
| 72 | RPS6KA4 | 0.86467184 |
| 73 | RPS6KL1 | 0.83669249 |
| 74 | RPS6KC1 | 0.83669249 |
| 75 | RPS6KA2 | 0.83667863 |
| 76 | RET | 0.83377174 |
| 77 | CSF1R | 0.81945582 |
| 78 | IRAK3 | 0.81831104 |
| 79 | PRKG2 | 0.81764214 |
| 80 | MAP2K3 | 0.81431790 |
| 81 | PRKCH | 0.80878367 |
| 82 | IRAK4 | 0.79374476 |
| 83 | LYN | 0.75460123 |
| 84 | EPHB2 | 0.74473492 |
| 85 | RPS6KA6 | 0.74297347 |
| 86 | DAPK2 | 0.73559479 |
| 87 | ILK | 0.71617404 |
| 88 | EPHA3 | 0.71306751 |
| 89 | MATK | 0.70242934 |
| 90 | ARAF | 0.68328022 |
| 91 | ADRBK2 | 0.67909254 |
| 92 | HIPK2 | 0.67545972 |
| 93 | BTK | 0.66774229 |
| 94 | MARK3 | 0.65730414 |
| 95 | SCYL2 | 0.65547494 |
| 96 | CHUK | 0.63774827 |
| 97 | PDPK1 | 0.62280349 |
| 98 | MAP3K11 | 0.61872812 |
| 99 | MAP3K1 | 0.60970629 |
| 100 | JAK2 | 0.60726604 |
| 101 | CAMKK2 | 0.58489451 |
| 102 | TYRO3 | 0.57968973 |
| 103 | MAPK4 | 0.57966233 |
| 104 | BMPR2 | 0.57832968 |
| 105 | SMG1 | 0.55178030 |
| 106 | FGFR3 | 0.54513333 |
| 107 | EGFR | 0.54454430 |
| 108 | ABL1 | 0.52784117 |
| 109 | FGFR4 | 0.52778480 |
| 110 | PRKD3 | 0.52759879 |
| 111 | ADRBK1 | 0.51402592 |
| 112 | TESK1 | 0.51128980 |
| 113 | CDK6 | 0.50677435 |
| 114 | PIM1 | 0.50082248 |
| 115 | MTOR | 0.49864584 |
| 116 | PAK3 | 0.49729658 |
| 117 | MAP3K5 | 0.48908562 |
| 118 | ABL2 | 0.48546298 |
| 119 | LCK | 0.47769392 |
| 120 | ROCK2 | 0.47287498 |
| 121 | GRK6 | 0.46439460 |
| 122 | MAP2K2 | 0.46232698 |
| 123 | SRC | 0.45883372 |
| 124 | PDK1 | 0.45715672 |
| 125 | PLK2 | 0.45644661 |
| 126 | ICK | 0.44469494 |
| 127 | FYN | 0.44182786 |
| 128 | MAP2K1 | 0.44057143 |
| 129 | MAP3K3 | 0.43467651 |
| 130 | PRKD1 | 0.41392006 |
| 131 | SIK3 | 0.41351760 |
| 132 | INSR | 0.40854731 |
| 133 | CLK1 | 0.40281460 |
| 134 | STK38 | 0.40260880 |
| 135 | STK3 | 0.39914015 |
| 136 | TESK2 | 0.39771723 |
| 137 | TXK | 0.38627492 |
| 138 | PRKCD | 0.38346882 |
| 139 | MAP2K6 | 0.37146276 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Other glycan degradation_Homo sapiens_hsa00511 | 3.11074945 |
| 2 | Leishmaniasis_Homo sapiens_hsa05140 | 2.26922627 |
| 3 | Malaria_Homo sapiens_hsa05144 | 1.98273758 |
| 4 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.97107054 |
| 5 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.74113413 |
| 6 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.70283575 |
| 7 | Amoebiasis_Homo sapiens_hsa05146 | 1.68704334 |
| 8 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.68383508 |
| 9 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.66907252 |
| 10 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.64520482 |
| 11 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.61773078 |
| 12 | Focal adhesion_Homo sapiens_hsa04510 | 1.55604219 |
| 13 | Tuberculosis_Homo sapiens_hsa05152 | 1.53082848 |
| 14 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.49069958 |
| 15 | Shigellosis_Homo sapiens_hsa05131 | 1.47909832 |
| 16 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.47525952 |
| 17 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.45868823 |
| 18 | Pertussis_Homo sapiens_hsa05133 | 1.44047821 |
| 19 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.43118667 |
| 20 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 1.41874169 |
| 21 | Salmonella infection_Homo sapiens_hsa05132 | 1.41635266 |
| 22 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.40817416 |
| 23 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.38164132 |
| 24 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.35699840 |
| 25 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.34611319 |
| 26 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.32802259 |
| 27 | Glioma_Homo sapiens_hsa05214 | 1.30444282 |
| 28 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 1.25782010 |
| 29 | Phagosome_Homo sapiens_hsa04145 | 1.25532854 |
| 30 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.23046201 |
| 31 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.21367788 |
| 32 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.21280392 |
| 33 | Lysosome_Homo sapiens_hsa04142 | 1.20740408 |
| 34 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.19951924 |
| 35 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.17595645 |
| 36 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.15000821 |
| 37 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.12784250 |
| 38 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.12670465 |
| 39 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.12197087 |
| 40 | Apoptosis_Homo sapiens_hsa04210 | 1.11652303 |
| 41 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.11335166 |
| 42 | Legionellosis_Homo sapiens_hsa05134 | 1.10549332 |
| 43 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.08432904 |
| 44 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.07488836 |
| 45 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.07453976 |
| 46 | Platelet activation_Homo sapiens_hsa04611 | 1.06205266 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.05559916 |
| 48 | Hepatitis B_Homo sapiens_hsa05161 | 1.04025980 |
| 49 | Bladder cancer_Homo sapiens_hsa05219 | 1.02679105 |
| 50 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.02473345 |
| 51 | Prion diseases_Homo sapiens_hsa05020 | 1.01214927 |
| 52 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.00614720 |
| 53 | Measles_Homo sapiens_hsa05162 | 0.99769832 |
| 54 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.99321204 |
| 55 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.95921504 |
| 56 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.94478627 |
| 57 | Endocytosis_Homo sapiens_hsa04144 | 0.93773730 |
| 58 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.91709840 |
| 59 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.91382774 |
| 60 | Viral myocarditis_Homo sapiens_hsa05416 | 0.90457812 |
| 61 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.87589664 |
| 62 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.86800217 |
| 63 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.86718331 |
| 64 | Influenza A_Homo sapiens_hsa05164 | 0.86659227 |
| 65 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.86223176 |
| 66 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.86093412 |
| 67 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.83947426 |
| 68 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.83225475 |
| 69 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.82957337 |
| 70 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.82625858 |
| 71 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.82058559 |
| 72 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.81506981 |
| 73 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.80761247 |
| 74 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.79086753 |
| 75 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.78476947 |
| 76 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.77696364 |
| 77 | Adherens junction_Homo sapiens_hsa04520 | 0.77677633 |
| 78 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.76141836 |
| 79 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.75550911 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.74638351 |
| 81 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.73490232 |
| 82 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.73101707 |
| 83 | Mineral absorption_Homo sapiens_hsa04978 | 0.72633832 |
| 84 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.72449681 |
| 85 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.71780585 |
| 86 | Melanoma_Homo sapiens_hsa05218 | 0.71379591 |
| 87 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.71355049 |
| 88 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.70379137 |
| 89 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.69740033 |
| 90 | Asthma_Homo sapiens_hsa05310 | 0.69654364 |
| 91 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.69392172 |
| 92 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.69230741 |
| 93 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.67353217 |
| 94 | Hepatitis C_Homo sapiens_hsa05160 | 0.67254759 |
| 95 | Allograft rejection_Homo sapiens_hsa05330 | 0.66482923 |
| 96 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.65862203 |
| 97 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.64089017 |
| 98 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.62616913 |
| 99 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.61396437 |
| 100 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.60522958 |
| 101 | Prostate cancer_Homo sapiens_hsa05215 | 0.59535831 |
| 102 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.59282519 |
| 103 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.58791920 |
| 104 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.58427142 |
| 105 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.57413038 |
| 106 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.57020835 |
| 107 | Colorectal cancer_Homo sapiens_hsa05210 | 0.56997056 |
| 108 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.56546983 |
| 109 | Insulin resistance_Homo sapiens_hsa04931 | 0.56249308 |
| 110 | HTLV-I infection_Homo sapiens_hsa05166 | 0.56037004 |
| 111 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.55633452 |
| 112 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.50810125 |
| 113 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.48559465 |
| 114 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.47888468 |
| 115 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.46858782 |
| 116 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.44387692 |
| 117 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.43498890 |
| 118 | Galactose metabolism_Homo sapiens_hsa00052 | 0.42331743 |
| 119 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.39308168 |
| 120 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.37808270 |
| 121 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.37562663 |
| 122 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.34577762 |

