JMJD1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with thyroid hormone receptors and contains a jumonji domain. It is a candidate histone demethylase and is thought to be a coactivator for key transcription factors. It plays a role in the DNA-damage response pathway by demethylating the mediator of DNA damage checkpoint 1 (MDC1) protein, and is required for the survival of acute myeloid leukemia. Mutations in this gene are associated with Rett syndrome and intellectual disability. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.69424261
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.60575846
3negative regulation of translation, ncRNA-mediated (GO:0040033)4.60575846
4regulation of translation, ncRNA-mediated (GO:0045974)4.60575846
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.52973287
6establishment of protein localization to Golgi (GO:0072600)4.38443530
7detection of molecule of bacterial origin (GO:0032490)4.38307044
8cellular extravasation (GO:0045123)4.31620336
9protein targeting to Golgi (GO:0000042)4.06138506
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05484732
11mitotic sister chromatid cohesion (GO:0007064)3.95130376
12retrograde transport, vesicle recycling within Golgi (GO:0000301)3.88199692
13regulation of RNA export from nucleus (GO:0046831)3.85411397
14neutrophil mediated immunity (GO:0002446)3.85026151
15histone H3-K4 methylation (GO:0051568)3.78138056
16microglial cell activation (GO:0001774)3.71233501
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69248404
18cytoplasmic mRNA processing body assembly (GO:0033962)3.68884509
19nuclear pore complex assembly (GO:0051292)3.60778404
20embryonic process involved in female pregnancy (GO:0060136)3.50347869
21cellular response to ethanol (GO:0071361)3.47405676
22peptidyl-lysine trimethylation (GO:0018023)3.45165869
23protein K11-linked deubiquitination (GO:0035871)3.43529239
24regulation of nucleobase-containing compound transport (GO:0032239)3.42461650
25negative regulation of fibroblast apoptotic process (GO:2000270)3.36216429
26negative regulation of granulocyte differentiation (GO:0030853)3.32997565
27histone H3-K36 demethylation (GO:0070544)3.31620479
28myeloid leukocyte mediated immunity (GO:0002444)3.29980198
29neural tube formation (GO:0001841)3.14594977
30regulation of protein polyubiquitination (GO:1902914)3.13773344
31histone lysine methylation (GO:0034968)3.13522235
32regulation of fibroblast apoptotic process (GO:2000269)3.13121505
33positive regulation of developmental pigmentation (GO:0048087)3.12932252
34positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.10445393
35nuclear pore organization (GO:0006999)3.08103731
36pre-miRNA processing (GO:0031054)3.06685824
37regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.06656638
38positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.06656638
39regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.05110776
40pore complex assembly (GO:0046931)3.04994416
41regulation of DNA endoreduplication (GO:0032875)3.04891536
42regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.04617807
43positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.04617807
44protein K48-linked deubiquitination (GO:0071108)3.03490828
45macrophage activation (GO:0042116)2.95123335
46protein K63-linked deubiquitination (GO:0070536)2.94399489
47regulation of pigment cell differentiation (GO:0050932)2.93692184
48N-terminal protein amino acid acetylation (GO:0006474)2.91612165
49negative regulation of DNA repair (GO:0045738)2.88365417
50regulation of posttranscriptional gene silencing (GO:0060147)2.88325778
51regulation of gene silencing by miRNA (GO:0060964)2.88325778
52regulation of gene silencing by RNA (GO:0060966)2.88325778
53regulation of MHC class II biosynthetic process (GO:0045346)2.86715695
54embryonic placenta development (GO:0001892)2.86628073
55regulation of integrin activation (GO:0033623)2.86255460
56histone H3-K9 demethylation (GO:0033169)2.82551356
57histone lysine demethylation (GO:0070076)2.82348747
58positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.82323397
59NLS-bearing protein import into nucleus (GO:0006607)2.81966812
60positive regulation of mRNA catabolic process (GO:0061014)2.81803162
61regulation of interferon-beta biosynthetic process (GO:0045357)2.81794767
62negative regulation of histone methylation (GO:0031061)2.80394979
63negative regulation of NF-kappaB import into nucleus (GO:0042347)2.78521648
64positive regulation of gamma-delta T cell activation (GO:0046645)2.76156434
65histone H3-K9 methylation (GO:0051567)2.75203072
66histone H3-K9 modification (GO:0061647)2.74459463
67definitive hemopoiesis (GO:0060216)2.73577883
68interkinetic nuclear migration (GO:0022027)2.72124870
69positive regulation of mitotic sister chromatid separation (GO:1901970)2.68026973
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68026973
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68026973
72histone demethylation (GO:0016577)2.67755659
73regulation of mRNA catabolic process (GO:0061013)2.67707132
74regulation of histone H3-K9 methylation (GO:0051570)2.67660069
75positive regulation of mRNA 3-end processing (GO:0031442)2.67106524
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66966956
77negative regulation of cell killing (GO:0031342)2.66966956
78centrosome localization (GO:0051642)2.66716473
79early endosome to late endosome transport (GO:0045022)2.66541051
80embryonic camera-type eye morphogenesis (GO:0048596)2.66419833
81prenylation (GO:0097354)2.66276146
82protein prenylation (GO:0018342)2.66276146
83I-kappaB phosphorylation (GO:0007252)2.65780132
84regulation of establishment of cell polarity (GO:2000114)2.62701243
85peptidyl-lysine methylation (GO:0018022)2.62197197
86detection of external biotic stimulus (GO:0098581)2.61588756
87histone mRNA catabolic process (GO:0071044)2.61584472
88embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60496532
89positive regulation of interferon-alpha production (GO:0032727)2.58098368
90regulation of mRNA 3-end processing (GO:0031440)2.55719397
91protein localization to Golgi apparatus (GO:0034067)2.55342698
92positive regulation of interferon-beta production (GO:0032728)2.55234470
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.52901783
94histone methylation (GO:0016571)2.50661706
95mRNA splice site selection (GO:0006376)2.48708937
96protein targeting to lysosome (GO:0006622)2.48162637
97establishment of protein localization to vacuole (GO:0072666)2.48162637
98protein targeting to vacuole (GO:0006623)2.48162637
99regulation of gene silencing (GO:0060968)2.46807010
100detection of biotic stimulus (GO:0009595)2.45677310
101DNA demethylation (GO:0080111)2.45625969
102positive regulation of granulocyte differentiation (GO:0030854)2.45195322
103microtubule anchoring (GO:0034453)2.43632167
104modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43153179
105positive regulation by organism of defense response of other organism involved in symbiotic interact2.43153179
106modulation by symbiont of host immune response (GO:0052553)2.43153179
107positive regulation by symbiont of host defense response (GO:0052509)2.43153179
108modulation by symbiont of host defense response (GO:0052031)2.43153179
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43153179
110hepatocyte apoptotic process (GO:0097284)2.43068668
111negative regulation of B cell proliferation (GO:0030889)2.42780445
112regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42735069
113protein demethylation (GO:0006482)2.42257852
114protein dealkylation (GO:0008214)2.42257852
115determination of adult lifespan (GO:0008340)2.41291892
116regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.39917762
117embryonic hemopoiesis (GO:0035162)2.39301295
118histone H4-K16 acetylation (GO:0043984)2.39160481
119embryonic eye morphogenesis (GO:0048048)2.39152650
120positive regulation by host of viral transcription (GO:0043923)2.38960716
121B cell homeostasis (GO:0001782)2.32912900
122dosage compensation (GO:0007549)2.31674847
123monocyte differentiation (GO:0030224)2.31611212
124regulation of B cell receptor signaling pathway (GO:0050855)2.30312495
125positive regulation of SMAD protein import into nucleus (GO:0060391)2.29921427
126positive regulation of gene expression, epigenetic (GO:0045815)2.29558075
127glucocorticoid receptor signaling pathway (GO:0042921)2.26742087
128macrophage activation involved in immune response (GO:0002281)2.26079770
129germ cell migration (GO:0008354)2.25140769
130replication fork processing (GO:0031297)2.24869194
131regulation of gamma-delta T cell differentiation (GO:0045586)2.23456690
132poly(A)+ mRNA export from nucleus (GO:0016973)2.23280453
133germinal center formation (GO:0002467)2.22725352
134positive thymic T cell selection (GO:0045059)2.22291864
135positive regulation of histone deacetylation (GO:0031065)2.20528321
136regulation of chromatin silencing (GO:0031935)2.20250395
137regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.19847832
138face development (GO:0060324)2.19251223
139mRNA stabilization (GO:0048255)2.16889946
140RNA stabilization (GO:0043489)2.16889946
141regulation of sister chromatid cohesion (GO:0007063)2.16408076
142regulation of gamma-delta T cell activation (GO:0046643)2.16133097
143positive regulation of B cell differentiation (GO:0045579)2.15996116
144histone H4-K12 acetylation (GO:0043983)2.15845243
145DNA strand renaturation (GO:0000733)2.15245057
146B cell receptor signaling pathway (GO:0050853)2.14599038
147monoubiquitinated protein deubiquitination (GO:0035520)2.12631829
148negative regulation of stress fiber assembly (GO:0051497)2.08459539
149negative regulation of DNA-dependent DNA replication (GO:2000104)2.08131790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87681656
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.47695592
3E2F7_22180533_ChIP-Seq_HELA_Human3.91791592
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.49553656
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48640040
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.45974047
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66273246
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54594006
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.29513267
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.28264714
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27745233
12RUNX_20019798_ChIP-Seq_JUKART_Human2.21003276
13SCL_19346495_ChIP-Seq_HPC-7_Human2.08405792
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.99886527
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96546198
16TAF15_26573619_Chip-Seq_HEK293_Human1.95357950
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93933240
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93151465
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92439637
20* GBX2_23144817_ChIP-Seq_PC3_Human1.92200021
21TCF7_22412390_ChIP-Seq_EML_Mouse1.88153439
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86850896
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83543773
24MYC_22102868_ChIP-Seq_BL_Human1.82224773
25P300_19829295_ChIP-Seq_ESCs_Human1.81030106
26* FUS_26573619_Chip-Seq_HEK293_Human1.78817655
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76439621
28TP53_16413492_ChIP-PET_HCT116_Human1.74231426
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.69090081
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.68859678
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64272456
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62277151
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.61601282
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59795182
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59097954
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58542017
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58385638
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58385638
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57448358
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56920688
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56488908
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55512046
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52332696
44ER_23166858_ChIP-Seq_MCF-7_Human1.51077975
45PKCTHETA_26484144_Chip-Seq_BREAST_Human1.49785426
46IGF1R_20145208_ChIP-Seq_DFB_Human1.49774000
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49481599
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49275119
49SMAD4_21799915_ChIP-Seq_A2780_Human1.48486693
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.42456855
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.42456855
52KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.42456855
53* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40990540
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39806852
55VDR_22108803_ChIP-Seq_LS180_Human1.39518031
56* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39157848
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37839639
58KDM2B_26808549_Chip-Seq_DND41_Human1.37710244
59MYB_26560356_Chip-Seq_TH1_Human1.37498565
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37177879
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36853053
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35689513
63* EZH2_27294783_Chip-Seq_NPCs_Mouse1.34582558
64* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34385587
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33773677
66ZNF274_21170338_ChIP-Seq_K562_Hela1.32545504
67GATA1_22025678_ChIP-Seq_K562_Human1.32056286
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.31334357
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30571197
70* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30246728
71VDR_21846776_ChIP-Seq_THP-1_Human1.29865513
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29716822
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29282586
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29169971
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27585189
76* SPI1_23127762_ChIP-Seq_K562_Human1.26362000
77TCF4_23295773_ChIP-Seq_U87_Human1.26269358
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25822009
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25770745
80* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24947252
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24861944
82MYB_26560356_Chip-Seq_TH2_Human1.23664981
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.23250216
84BRD4_25478319_ChIP-Seq_HGPS_Human1.22201735
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.21558055
86CBP_20019798_ChIP-Seq_JUKART_Human1.21453355
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21453355
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21371333
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.21074018
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19983034
91* PU_27001747_Chip-Seq_BMDM_Mouse1.18775913
92* FLI1_21867929_ChIP-Seq_TH2_Mouse1.17356824
93* BCAT_22108803_ChIP-Seq_LS180_Human1.17132909
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.16442553
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.16230070
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.16217423
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15255587
98* CDX2_22108803_ChIP-Seq_LS180_Human1.13671389
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13171447
100AHR_22903824_ChIP-Seq_MCF-7_Human1.12799566
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12196053
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.12138216
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11823134
104MAF_26560356_Chip-Seq_TH1_Human1.11822749
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11272225
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11210223
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.10821241
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.10630530
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08686885
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07964573
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.07751935
112VDR_24763502_ChIP-Seq_THP-1_Human1.07536109
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06880634
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06025583
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05244637
116EWS_26573619_Chip-Seq_HEK293_Human1.05052341
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.05011492
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05002608
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04513141
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.04283474
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04063490
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03494348
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03329228
124VDR_24787735_ChIP-Seq_THP-1_Human1.03168613
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02859880
126* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02577233
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.02555886
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01472674
129NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01472674
130ESR1_21235772_ChIP-Seq_MCF-7_Human1.01429472
131* TCF4_22108803_ChIP-Seq_LS180_Human1.01001584
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99774280
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98598911
134* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97853142
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97062552
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97054156
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96835452
138UTX_26944678_Chip-Seq_JUKART_Human0.96220434
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95733714
140E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95428251
141RUNX1_22412390_ChIP-Seq_EML_Mouse0.93414730
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92720881
143AR_21572438_ChIP-Seq_LNCaP_Human0.92468942
144* STAT3_23295773_ChIP-Seq_U87_Human0.91509239
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88657664
146CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88243585
147ISL1_27105846_Chip-Seq_CPCs_Mouse0.88117292
148* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87772402
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87059792
150WT1_19549856_ChIP-ChIP_CCG9911_Human0.87015049
151E2F1_21310950_ChIP-Seq_MCF-7_Human0.86991602
152* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86640035
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85512014
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85436141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.57622177
2MP0008057_abnormal_DNA_replication3.57306643
3MP0003724_increased_susceptibility_to2.84756181
4MP0009278_abnormal_bone_marrow2.63400520
5MP0005076_abnormal_cell_differentiation2.60040766
6MP0002009_preneoplasia2.55771807
7MP0002396_abnormal_hematopoietic_system2.50087940
8MP0003045_fibrosis2.28839024
9MP0005174_abnormal_tail_pigmentation2.27905191
10MP0003787_abnormal_imprinting2.26525015
11MP0002166_altered_tumor_susceptibility2.26524059
12MP0004808_abnormal_hematopoietic_stem2.15052669
13MP0003300_gastrointestinal_ulcer2.12259582
14MP0010352_gastrointestinal_tract_polyps2.03405761
15MP0010307_abnormal_tumor_latency2.01661359
16MP0008877_abnormal_DNA_methylation1.96069024
17MP0003172_abnormal_lysosome_physiology1.81370699
18MP0000015_abnormal_ear_pigmentation1.78773427
19MP0005171_absent_coat_pigmentation1.74443434
20MP0003656_abnormal_erythrocyte_physiolo1.71549883
21MP0003566_abnormal_cell_adhesion1.67917022
22MP0003828_pulmonary_edema1.66276120
23MP0002006_tumorigenesis1.65544935
24MP0000371_diluted_coat_color1.64963247
25MP0003221_abnormal_cardiomyocyte_apopto1.53569154
26MP0002877_abnormal_melanocyte_morpholog1.53198625
27MP0010094_abnormal_chromosome_stability1.51831772
28MP0001800_abnormal_humoral_immune1.49673510
29MP0003890_abnormal_embryonic-extraembry1.48351271
30MP0001545_abnormal_hematopoietic_system1.48310247
31MP0005397_hematopoietic_system_phenotyp1.48310247
32MP0003941_abnormal_skin_development1.46031738
33MP0003091_abnormal_cell_migration1.43877688
34MP0001915_intracranial_hemorrhage1.41752824
35MP0000733_abnormal_muscle_development1.41408953
36MP0000703_abnormal_thymus_morphology1.32713074
37MP0003111_abnormal_nucleus_morphology1.32337161
38MP0001835_abnormal_antigen_presentation1.32104141
39MP0003195_calcinosis1.31494297
40MP0001188_hyperpigmentation1.28374371
41MP0002452_abnormal_antigen_presenting1.27246677
42MP0002398_abnormal_bone_marrow1.27094472
43MP0002086_abnormal_extraembryonic_tissu1.23976273
44MP0002928_abnormal_bile_duct1.23878683
45MP0008058_abnormal_DNA_repair1.22575941
46MP0010678_abnormal_skin_adnexa1.22030046
47MP0005310_abnormal_salivary_gland1.21802588
48MP0003303_peritoneal_inflammation1.21072272
49MP0004883_abnormal_blood_vessel1.20080523
50MP0003183_abnormal_peptide_metabolism1.16708272
51MP0009703_decreased_birth_body1.15529027
52MP0004197_abnormal_fetal_growth/weight/1.14430796
53MP0002095_abnormal_skin_pigmentation1.13962705
54MP0000767_abnormal_smooth_muscle1.12614612
55MP0001873_stomach_inflammation1.12229967
56MP0002925_abnormal_cardiovascular_devel1.12156952
57MP0001851_eye_inflammation1.11979120
58MP0003943_abnormal_hepatobiliary_system1.10117441
59MP0005387_immune_system_phenotype1.10062638
60MP0001790_abnormal_immune_system1.10062638
61MP0003763_abnormal_thymus_physiology1.09617344
62MP0002075_abnormal_coat/hair_pigmentati1.06309699
63MP0004264_abnormal_extraembryonic_tissu1.05941659
64MP0000689_abnormal_spleen_morphology1.05582991
65MP0001293_anophthalmia1.05579622
66MP0005671_abnormal_response_to1.03510310
67MP0002420_abnormal_adaptive_immunity1.02315927
68MP0008007_abnormal_cellular_replicative1.02257278
69MP0006054_spinal_hemorrhage1.01954814
70MP0002723_abnormal_immune_serum1.01603655
71MP0001819_abnormal_immune_cell1.00869156
72MP0000350_abnormal_cell_proliferation1.00628728
73MP0003984_embryonic_growth_retardation1.00567296
74MP0001177_atelectasis0.99980036
75MP0002088_abnormal_embryonic_growth/wei0.99046252
76MP0003077_abnormal_cell_cycle0.98989905
77MP0000716_abnormal_immune_system0.98457024
78MP0002084_abnormal_developmental_patter0.98202020
79MP0002722_abnormal_immune_system0.97595826
80MP0000432_abnormal_head_morphology0.97298362
81MP0000685_abnormal_immune_system0.96057340
82MP0001672_abnormal_embryogenesis/_devel0.94869102
83MP0005380_embryogenesis_phenotype0.94869102
84MP0004484_altered_response_of0.93859945
85MP0005075_abnormal_melanosome_morpholog0.93581340
86MP0008961_abnormal_basal_metabolism0.92151086
87MP0001879_abnormal_lymphatic_vessel0.92077495
88MP0003121_genomic_imprinting0.91589498
89MP0003935_abnormal_craniofacial_develop0.91126755
90MP0002405_respiratory_system_inflammati0.90073543
91MP0003453_abnormal_keratinocyte_physiol0.89785755
92MP0000427_abnormal_hair_cycle0.88347692
93MP0005464_abnormal_platelet_physiology0.87621233
94MP0000383_abnormal_hair_follicle0.87440709
95MP0000516_abnormal_urinary_system0.87339557
96MP0005367_renal/urinary_system_phenotyp0.87339557
97MP0005000_abnormal_immune_tolerance0.87156522
98MP0002168_other_aberrant_phenotype0.87103824
99MP0005164_abnormal_response_to0.86741864
100MP0001853_heart_inflammation0.85750633
101MP0002277_abnormal_respiratory_mucosa0.84020046
102MP0002419_abnormal_innate_immunity0.84000514
103MP0008995_early_reproductive_senescence0.82793106
104MP0002254_reproductive_system_inflammat0.81683632
105MP0005023_abnormal_wound_healing0.81285479
106MP0001299_abnormal_eye_distance/0.81057005
107MP0000465_gastrointestinal_hemorrhage0.81031402
108MP0004510_myositis0.79575146
109MP0001784_abnormal_fluid_regulation0.79530177
110MP0002429_abnormal_blood_cell0.78131490
111MP0001697_abnormal_embryo_size0.77347489
112MP0004947_skin_inflammation0.77309474
113MP0010630_abnormal_cardiac_muscle0.76595297
114MP0005621_abnormal_cell_physiology0.76594667
115MP0002133_abnormal_respiratory_system0.76100644
116MP0005388_respiratory_system_phenotype0.76100644
117MP0003567_abnormal_fetal_cardiomyocyte0.75154459
118MP0004381_abnormal_hair_follicle0.74436269
119MP0003279_aneurysm0.73802451
120MP0002998_abnormal_bone_remodeling0.73745077
121MP0002092_abnormal_eye_morphology0.73521612
122MP0002085_abnormal_embryonic_tissue0.73409974
123MP0002697_abnormal_eye_size0.73194821
124MP0002933_joint_inflammation0.72848742
125MP0003690_abnormal_glial_cell0.70279492
126MP0001286_abnormal_eye_development0.67448797
127MP0003122_maternal_imprinting0.64276284
128MP0003868_abnormal_feces_composition0.63344512
129MP0002019_abnormal_tumor_incidence0.63050691
130MP0001191_abnormal_skin_condition0.61120543
131MP0008260_abnormal_autophagy0.61006858

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.49475326
2Abnormality of the fingertips (HP:0001211)4.20862134
3Volvulus (HP:0002580)3.69955737
4Stomach cancer (HP:0012126)3.44437993
5Abnormal hair whorl (HP:0010721)3.32628265
6Abnormality of the nasal septum (HP:0000419)3.20085485
7Subacute progressive viral hepatitis (HP:0006572)3.10944180
8T lymphocytopenia (HP:0005403)2.92486688
9Urethral obstruction (HP:0000796)2.89819835
10Abnormality of T cell number (HP:0011839)2.89387722
11Nephroblastoma (Wilms tumor) (HP:0002667)2.85394244
12Rhabdomyosarcoma (HP:0002859)2.80481649
13Fair hair (HP:0002286)2.79243205
14Thyroid carcinoma (HP:0002890)2.77912625
15Neoplasm of the tracheobronchial system (HP:0100552)2.73020061
16Hepatoblastoma (HP:0002884)2.72020315
17Embryonal renal neoplasm (HP:0011794)2.70325374
18Cerebral aneurysm (HP:0004944)2.69305023
19Macroorchidism (HP:0000053)2.69217890
20Narrow palate (HP:0000189)2.65848566
21Long eyelashes (HP:0000527)2.65248035
22Absent frontal sinuses (HP:0002688)2.64246650
23Curly hair (HP:0002212)2.60539432
24Protruding tongue (HP:0010808)2.59781199
25Gaze-evoked nystagmus (HP:0000640)2.42660758
26Lip pit (HP:0100267)2.42486059
27Neonatal hypoglycemia (HP:0001998)2.39340795
28Biliary tract neoplasm (HP:0100574)2.38657365
29Recurrent bacterial skin infections (HP:0005406)2.36802918
30Anal stenosis (HP:0002025)2.36694268
31Abnormality of chromosome stability (HP:0003220)2.35774266
32Acute myeloid leukemia (HP:0004808)2.35449835
33Medulloblastoma (HP:0002885)2.32956869
34Depressed nasal tip (HP:0000437)2.31183670
35Progressive cerebellar ataxia (HP:0002073)2.26849886
36Viral hepatitis (HP:0006562)2.21843253
37Aqueductal stenosis (HP:0002410)2.19196078
38Syringomyelia (HP:0003396)2.18645214
39Spinal cord lesions (HP:0100561)2.18645214
40Cystic hygroma (HP:0000476)2.18561158
41Hematochezia (HP:0002573)2.18052399
42Colon cancer (HP:0003003)2.17864912
43Hyperventilation (HP:0002883)2.17264796
44Neoplasm of the oral cavity (HP:0100649)2.15494926
45Retrobulbar optic neuritis (HP:0100654)2.15445920
46Optic neuritis (HP:0100653)2.15445920
47Truncal obesity (HP:0001956)2.12881996
48Supernumerary ribs (HP:0005815)2.12088705
49Thyroiditis (HP:0100646)2.11346059
50Cupped ear (HP:0000378)2.10877987
51Colitis (HP:0002583)2.09869860
52Aortic aneurysm (HP:0004942)2.09603263
53Intestinal fistula (HP:0100819)2.08435967
54Heterotopia (HP:0002282)2.08086212
55Trigonocephaly (HP:0000243)2.07904190
56Generalized hypopigmentation of hair (HP:0011358)2.06512494
57Neoplasm of striated muscle (HP:0009728)2.05372376
58Alveolar cell carcinoma (HP:0006519)2.03977810
59Febrile seizures (HP:0002373)2.02015579
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99760468
61Deep philtrum (HP:0002002)1.99721105
62Hypoplastic ischia (HP:0003175)1.98484623
63Limited elbow extension (HP:0001377)1.98398121
64Aplasia/Hypoplasia of the sternum (HP:0006714)1.96517324
65Oligodontia (HP:0000677)1.96516847
66Intestinal atresia (HP:0011100)1.95986754
67Prominent nose (HP:0000448)1.95687459
68IgM deficiency (HP:0002850)1.95082312
69Chronic hepatic failure (HP:0100626)1.93955409
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.93064345
71Spondylolisthesis (HP:0003302)1.91124079
72Stomatitis (HP:0010280)1.88991765
73Abnormal biliary tract morphology (HP:0012440)1.88407618
74Recurrent fungal infections (HP:0002841)1.87666631
75Abnormality of the labia minora (HP:0012880)1.87558181
76Broad thumb (HP:0011304)1.87198953
77Genetic anticipation (HP:0003743)1.86773961
78Hypoplastic labia majora (HP:0000059)1.85769753
79Acute lymphatic leukemia (HP:0006721)1.84748741
80Hypochromic microcytic anemia (HP:0004840)1.83523957
81Short 4th metacarpal (HP:0010044)1.82590929
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82590929
83Supernumerary bones of the axial skeleton (HP:0009144)1.81307670
84Recurrent abscess formation (HP:0002722)1.79586864
85Thick eyebrow (HP:0000574)1.79000139
86Neoplasm of the small intestine (HP:0100833)1.78873271
87Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78038142
88Sandal gap (HP:0001852)1.77852293
89Large earlobe (HP:0009748)1.76692816
90Obsessive-compulsive behavior (HP:0000722)1.76434761
91Hip dysplasia (HP:0001385)1.74466494
92Broad-based gait (HP:0002136)1.73509340
93Ectopic kidney (HP:0000086)1.73314170
94Drooling (HP:0002307)1.73297191
95Coarse hair (HP:0002208)1.72482309
96Orchitis (HP:0100796)1.72291562
97Abnormality of the ischium (HP:0003174)1.72249651
98Abnormality of the labia majora (HP:0012881)1.71786614
99Excessive salivation (HP:0003781)1.71309881
100Hypoplasia of the maxilla (HP:0000327)1.70799993
101Distal lower limb amyotrophy (HP:0008944)1.70688534
102Low anterior hairline (HP:0000294)1.70557503
103Arterial tortuosity (HP:0005116)1.70508728
104Keratoconjunctivitis sicca (HP:0001097)1.70184180
105Autoimmune hemolytic anemia (HP:0001890)1.69894796
106Spinal muscular atrophy (HP:0007269)1.68066004
107Recurrent viral infections (HP:0004429)1.67295724
108Oligodactyly (hands) (HP:0001180)1.66698730
109Inflammation of the large intestine (HP:0002037)1.66639802
110Abnormality of incisor morphology (HP:0011063)1.66616802
111Synophrys (HP:0000664)1.66320473
112Clitoromegaly (HP:0000057)1.66193076
113Overgrowth (HP:0001548)1.65253667
114Periodontitis (HP:0000704)1.65228241
115Dislocated radial head (HP:0003083)1.65005069
116Leukocytosis (HP:0001974)1.64643667
117Recurrent cutaneous fungal infections (HP:0011370)1.64335376
118Chronic mucocutaneous candidiasis (HP:0002728)1.64335376
119Abnormality of the frontal sinuses (HP:0002687)1.63803803
120Smooth philtrum (HP:0000319)1.63085821
121Ulnar bowing (HP:0003031)1.63073413
122Chromsome breakage (HP:0040012)1.62823500
123Transitional cell carcinoma of the bladder (HP:0006740)1.62126530
124Tubulointerstitial nephritis (HP:0001970)1.60648639
125Short chin (HP:0000331)1.59612666
126Leiomyosarcoma (HP:0100243)1.59130065
127Uterine leiomyosarcoma (HP:0002891)1.59130065
128Difficulty running (HP:0009046)1.59105517
129Broad palm (HP:0001169)1.58761207
130Submucous cleft hard palate (HP:0000176)1.57917736
131Spontaneous hematomas (HP:0007420)1.57602663
132Widely spaced teeth (HP:0000687)1.57329849
133Stenosis of the external auditory canal (HP:0000402)1.57244868
134Abnormality of the astrocytes (HP:0100707)1.57211958
135Astrocytoma (HP:0009592)1.57211958
136Inappropriate behavior (HP:0000719)1.57025234
137Keratoconjunctivitis (HP:0001096)1.56761582
138Abnormal pancreas size (HP:0012094)1.55403921
139Agammaglobulinemia (HP:0004432)1.55336038
140Glioma (HP:0009733)1.54771797
141Abnormality of the radial head (HP:0003995)1.53872809
142Chronic diarrhea (HP:0002028)1.53808331
143IgA deficiency (HP:0002720)1.53066367
144Persistence of primary teeth (HP:0006335)1.53064579
145Skull defect (HP:0001362)1.52859660
146Abnormality of the columella (HP:0009929)1.52683324
147Tapered finger (HP:0001182)1.51533844
148Facial hemangioma (HP:0000329)1.51531298
149Increased number of teeth (HP:0011069)1.50009254
150Broad phalanges of the hand (HP:0009768)1.49564625
151Abnormality of the hepatic vasculature (HP:0006707)1.49375378
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.49152989
153Gastrointestinal inflammation (HP:0004386)1.49137021
154Long clavicles (HP:0000890)1.49053249
155Neoplasm of the adrenal cortex (HP:0100641)1.48814174
156Wide nose (HP:0000445)1.47436237
157Hypotelorism (HP:0000601)1.47290192
158Abnormality of the incisor (HP:0000676)1.46332836
159Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.45839293
160Bladder carcinoma (HP:0002862)1.45363022
161Bladder neoplasm (HP:0009725)1.45363022
162Vascular tortuosity (HP:0004948)1.44941436
163Prostate neoplasm (HP:0100787)1.44424390
164Chromosomal breakage induced by crosslinking agents (HP:0003221)1.44410641
165Thin upper lip vermilion (HP:0000219)1.44319816
166Malignant gastrointestinal tract tumors (HP:0006749)1.44307013
167Gastrointestinal carcinoma (HP:0002672)1.44307013
168Rib fusion (HP:0000902)1.44205315
169Cutis marmorata (HP:0000965)1.43664375
170Anteriorly placed anus (HP:0001545)1.43626813

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.37077034
2BRSK22.76468157
3CAMK1D2.74502514
4TNIK2.59899380
5CAMK1G2.52051283
6BRD42.34174601
7MAPK152.33450612
8NLK2.30866008
9TGFBR22.24725425
10ICK2.23108180
11ACVR1B2.08696162
12STK38L1.91622936
13MAP3K101.88235837
14CDK61.78251233
15MST41.76821077
16IRAK11.75848233
17LATS11.75015193
18MAP3K61.68777909
19STK101.60315617
20RIPK11.59941210
21WNK31.53433025
22BLK1.52986409
23FGFR31.45507685
24MKNK21.43198127
25CASK1.41388502
26CHUK1.39967738
27MAP3K141.39170324
28PIK3CG1.37527933
29EIF2AK31.34205837
30MTOR1.32667737
31DMPK1.31310526
32PDGFRB1.27866498
33MAP3K21.26385200
34JAK11.23504290
35NUAK11.21104792
36SIK21.20708533
37CDK91.19940884
38SGK4941.19469942
39SGK2231.19469942
40SGK31.19038127
41CSK1.18767131
42BMPR1B1.18089076
43IRAK21.17834576
44ITK1.16765337
45MAP4K11.15922245
46RIPK41.14590185
47BMPR21.14069192
48BTK1.13128674
49IRAK41.12774378
50STK31.08657668
51PDGFRA1.08438227
52ATR1.07601336
53MATK1.07189594
54MAP3K131.06433287
55CSF1R1.05565852
56SGK21.05416273
57YES11.04890581
58STK241.03987429
59DDR21.03458160
60IKBKE1.03233530
61SIK11.02692858
62PIM11.02322923
63HIPK21.00972244
64PTK61.00550548
65TRPM71.00092858
66INSRR0.99912669
67EPHB10.97691500
68MAPK70.96320486
69WNK10.96287536
70DYRK30.94622834
71TAF10.94521836
72KIT0.94185175
73ZAK0.92951940
74IKBKB0.90481647
75EPHA30.90117046
76CDC70.89709957
77MAP3K40.89573924
78PAK30.87129278
79JAK30.86912826
80FGFR20.86173789
81OXSR10.84798671
82MARK20.83980989
83ATM0.83677049
84PRKAA20.83263941
85EEF2K0.82804091
86DYRK1A0.81027441
87PNCK0.80656392
88ALK0.80314168
89MKNK10.79661875
90AKT30.79614314
91CDK30.79164966
92TYK20.78626918
93HCK0.77121852
94SGK10.75097328
95GSK3A0.74703671
96MELK0.74081430
97MAP2K30.73225614
98FES0.72696746
99CAMK40.71969473
100BMX0.71793857
101PRKD20.71634846
102CDC42BPA0.71248494
103TSSK60.71062021
104FRK0.68955086
105EPHA20.68159590
106FGR0.67540094
107TAOK30.66492451
108MAPK140.66061385
109RPS6KA40.65218210
110FLT30.65047253
111FGFR10.64302863
112MARK30.64018824
113TXK0.63581191
114STK40.63524853
115MAP3K70.62788782
116TEC0.62419609
117CHEK10.61668252
118MAP4K20.61408044
119CLK10.61147443
120MAPK10.60797420
121LCK0.60173935
122EGFR0.58986330
123CDK20.58850508
124STK110.58591860
125PLK30.58464059
126PTK2B0.58102196
127WEE10.57099858
128SIK30.56506779
129MAPK100.55043460
130CHEK20.54775931
131FGFR40.54704560
132SYK0.54134805
133TYRO30.54075466
134INSR0.53642754
135ERBB40.52855855
136CDK70.52678238
137JAK20.52499904
138ERBB20.52170780
139CDK40.48763394
140LYN0.48569484
141PRKDC0.48527391
142PLK40.48263474
143PLK20.48136702
144ERBB30.47675767
145NEK60.46187759
146KSR10.44665415
147BCR0.43449591
148TIE10.38941894

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003101.88224637
2B cell receptor signaling pathway_Homo sapiens_hsa046621.83186967
3Adherens junction_Homo sapiens_hsa045201.70139967
4Osteoclast differentiation_Homo sapiens_hsa043801.65350362
5* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.58404519
6Chronic myeloid leukemia_Homo sapiens_hsa052201.53014195
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.52258290
8MicroRNAs in cancer_Homo sapiens_hsa052061.51241399
9Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47512127
10Notch signaling pathway_Homo sapiens_hsa043301.47441514
11Primary immunodeficiency_Homo sapiens_hsa053401.39172318
12mTOR signaling pathway_Homo sapiens_hsa041501.25155595
13Small cell lung cancer_Homo sapiens_hsa052221.23265569
14Legionellosis_Homo sapiens_hsa051341.20757531
15Pancreatic cancer_Homo sapiens_hsa052121.19707915
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19124189
17Dorso-ventral axis formation_Homo sapiens_hsa043201.18565748
18Colorectal cancer_Homo sapiens_hsa052101.14098217
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11086230
20Measles_Homo sapiens_hsa051621.10559778
21Type II diabetes mellitus_Homo sapiens_hsa049301.10525713
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09197650
23T cell receptor signaling pathway_Homo sapiens_hsa046601.08713235
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08406496
25Leishmaniasis_Homo sapiens_hsa051401.07779419
26Acute myeloid leukemia_Homo sapiens_hsa052211.07774343
27Hepatitis B_Homo sapiens_hsa051611.06666658
28Prostate cancer_Homo sapiens_hsa052151.06529917
29Herpes simplex infection_Homo sapiens_hsa051681.06354181
30Toxoplasmosis_Homo sapiens_hsa051451.04726762
31Basal transcription factors_Homo sapiens_hsa030221.04555189
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04349169
33Non-homologous end-joining_Homo sapiens_hsa034501.03622335
34Staphylococcus aureus infection_Homo sapiens_hsa051501.03476323
35TNF signaling pathway_Homo sapiens_hsa046681.02163720
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.01124331
37Circadian rhythm_Homo sapiens_hsa047101.00896613
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00471027
39Proteoglycans in cancer_Homo sapiens_hsa052051.00262765
40mRNA surveillance pathway_Homo sapiens_hsa030151.00034833
41TGF-beta signaling pathway_Homo sapiens_hsa043500.98111677
42Inositol phosphate metabolism_Homo sapiens_hsa005620.97744208
43RNA degradation_Homo sapiens_hsa030180.97244357
44MAPK signaling pathway_Homo sapiens_hsa040100.95896231
45HTLV-I infection_Homo sapiens_hsa051660.94995616
46FoxO signaling pathway_Homo sapiens_hsa040680.94621638
47Hematopoietic cell lineage_Homo sapiens_hsa046400.94259499
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92722275
49Viral carcinogenesis_Homo sapiens_hsa052030.92151419
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.91786033
51Fanconi anemia pathway_Homo sapiens_hsa034600.91716969
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90429387
53Graft-versus-host disease_Homo sapiens_hsa053320.90076201
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.89846480
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89509062
56Antigen processing and presentation_Homo sapiens_hsa046120.89416042
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88584573
58Viral myocarditis_Homo sapiens_hsa054160.88508553
59Chemokine signaling pathway_Homo sapiens_hsa040620.88152111
60Focal adhesion_Homo sapiens_hsa045100.86532250
61Choline metabolism in cancer_Homo sapiens_hsa052310.86013914
62Apoptosis_Homo sapiens_hsa042100.85669390
63Long-term depression_Homo sapiens_hsa047300.85494502
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85228115
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84914015
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84876526
67Platelet activation_Homo sapiens_hsa046110.84802505
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84777303
69Type I diabetes mellitus_Homo sapiens_hsa049400.84660958
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83750840
71Influenza A_Homo sapiens_hsa051640.82450048
72ErbB signaling pathway_Homo sapiens_hsa040120.81341448
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80324146
74Wnt signaling pathway_Homo sapiens_hsa043100.80171795
75Non-small cell lung cancer_Homo sapiens_hsa052230.79453150
76Endometrial cancer_Homo sapiens_hsa052130.79298705
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.78685656
78Homologous recombination_Homo sapiens_hsa034400.78234903
79Fatty acid biosynthesis_Homo sapiens_hsa000610.77991276
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77856433
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76920560
82Thyroid cancer_Homo sapiens_hsa052160.75748626
83Glioma_Homo sapiens_hsa052140.75330310
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.74196709
85Prolactin signaling pathway_Homo sapiens_hsa049170.73827957
86Pathways in cancer_Homo sapiens_hsa052000.73594532
87Cell cycle_Homo sapiens_hsa041100.72550177
88Long-term potentiation_Homo sapiens_hsa047200.72495488
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72013236
90Hippo signaling pathway_Homo sapiens_hsa043900.70032910
91Rap1 signaling pathway_Homo sapiens_hsa040150.69617942
92p53 signaling pathway_Homo sapiens_hsa041150.69609589
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69207682
94Regulation of autophagy_Homo sapiens_hsa041400.67306902
95Estrogen signaling pathway_Homo sapiens_hsa049150.67105624
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.65846852
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65397885
98HIF-1 signaling pathway_Homo sapiens_hsa040660.65360443
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64843305
100ECM-receptor interaction_Homo sapiens_hsa045120.63613460
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62716485
102Shigellosis_Homo sapiens_hsa051310.62076687
103Insulin resistance_Homo sapiens_hsa049310.61969501
104Allograft rejection_Homo sapiens_hsa053300.61847213
105Renal cell carcinoma_Homo sapiens_hsa052110.61432056
106Autoimmune thyroid disease_Homo sapiens_hsa053200.59740976
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59678609
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.59554368
109Basal cell carcinoma_Homo sapiens_hsa052170.58852545
110Malaria_Homo sapiens_hsa051440.58819648
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58797385
112Tuberculosis_Homo sapiens_hsa051520.58027481
113VEGF signaling pathway_Homo sapiens_hsa043700.56990645
114Hepatitis C_Homo sapiens_hsa051600.56772573
115cAMP signaling pathway_Homo sapiens_hsa040240.56576351
116African trypanosomiasis_Homo sapiens_hsa051430.55384490
117Melanoma_Homo sapiens_hsa052180.55126476
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53793906
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52975449
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51095469
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49766998
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48665058

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