JMJD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.31926715
2negative regulation of interleukin-12 production (GO:0032695)4.19269481
3cellular response to arsenic-containing substance (GO:0071243)4.16984496
4mitotic metaphase plate congression (GO:0007080)4.05592966
5nucleobase biosynthetic process (GO:0046112)4.04585902
6formation of translation preinitiation complex (GO:0001731)3.98284983
7positive regulation of protein homooligomerization (GO:0032464)3.97381876
8purine nucleobase biosynthetic process (GO:0009113)3.88010342
9protein localization to kinetochore (GO:0034501)3.87879467
10maturation of SSU-rRNA (GO:0030490)3.85345379
11DNA replication initiation (GO:0006270)3.81310815
12metaphase plate congression (GO:0051310)3.76506170
13mitotic nuclear envelope disassembly (GO:0007077)3.75611853
14IMP biosynthetic process (GO:0006188)3.75132964
15DNA strand elongation involved in DNA replication (GO:0006271)3.74407867
16ribosome biogenesis (GO:0042254)3.73382593
17regulation of vitamin D biosynthetic process (GO:0060556)3.72562128
18nuclear pore organization (GO:0006999)3.71542413
19DNA replication checkpoint (GO:0000076)3.66552899
20nuclear pore complex assembly (GO:0051292)3.63399521
21DNA strand elongation (GO:0022616)3.63117414
22ribosomal small subunit assembly (GO:0000028)3.55062045
23telomere maintenance via semi-conservative replication (GO:0032201)3.54601714
24protein localization to chromosome, centromeric region (GO:0071459)3.47080424
25nuclear envelope disassembly (GO:0051081)3.45988567
26membrane disassembly (GO:0030397)3.45988567
27DNA replication-dependent nucleosome assembly (GO:0006335)3.45648729
28DNA replication-dependent nucleosome organization (GO:0034723)3.45648729
29NIK/NF-kappaB signaling (GO:0038061)3.45245407
30germinal center formation (GO:0002467)3.42442344
31DNA unwinding involved in DNA replication (GO:0006268)3.41566057
32positive regulation of gamma-delta T cell activation (GO:0046645)3.37567412
33ribosome assembly (GO:0042255)3.37500815
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.37322548
35establishment of chromosome localization (GO:0051303)3.33460842
36regulation of spindle organization (GO:0090224)3.31777903
37lipopolysaccharide-mediated signaling pathway (GO:0031663)3.31340475
38ribonucleoprotein complex biogenesis (GO:0022613)3.26215973
39telomere maintenance via recombination (GO:0000722)3.26014941
40DNA deamination (GO:0045006)3.25796444
41negative regulation of interleukin-1 beta production (GO:0032691)3.25572328
42CENP-A containing nucleosome assembly (GO:0034080)3.24941269
43response to muramyl dipeptide (GO:0032495)3.21443797
44chromatin remodeling at centromere (GO:0031055)3.20927450
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18628163
46rRNA modification (GO:0000154)3.15443210
47DNA replication-independent nucleosome organization (GO:0034724)3.15441353
48DNA replication-independent nucleosome assembly (GO:0006336)3.15441353
49IMP metabolic process (GO:0046040)3.13706974
50mitotic chromosome condensation (GO:0007076)3.12871194
51immunoglobulin mediated immune response (GO:0016064)3.09370751
52mitotic recombination (GO:0006312)3.08943590
53ribosomal large subunit biogenesis (GO:0042273)3.06433464
54kinetochore organization (GO:0051383)3.06414170
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.05404379
56folic acid-containing compound biosynthetic process (GO:0009396)3.02081328
57proteasome assembly (GO:0043248)3.01141572
58negative regulation of interleukin-1 production (GO:0032692)2.99683008
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99538907
60pore complex assembly (GO:0046931)2.98412067
61telomere maintenance via telomere lengthening (GO:0010833)2.98326066
62protein K6-linked ubiquitination (GO:0085020)2.95812126
63leukocyte aggregation (GO:0070486)2.94327431
64neutrophil mediated immunity (GO:0002446)2.94048194
65rRNA processing (GO:0006364)2.92586734
66activation of MAPKKK activity (GO:0000185)2.92519800
67spliceosomal snRNP assembly (GO:0000387)2.90366381
68regulation of mitotic spindle organization (GO:0060236)2.88877084
69rRNA metabolic process (GO:0016072)2.85409003
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.84887558
71negative regulation of interleukin-6 production (GO:0032715)2.83854557
72positive regulation of interleukin-1 beta secretion (GO:0050718)2.82254687
73viral mRNA export from host cell nucleus (GO:0046784)2.81858125
74kinetochore assembly (GO:0051382)2.81360319
75RNA destabilization (GO:0050779)2.80655410
76regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80287496
77negative regulation of interleukin-8 production (GO:0032717)2.80083104
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.79869086
79protein localization to chromosome (GO:0034502)2.78931644
80transcription-coupled nucleotide-excision repair (GO:0006283)2.78663330
81rRNA methylation (GO:0031167)2.78585108
82termination of RNA polymerase I transcription (GO:0006363)2.76886940
83somatic hypermutation of immunoglobulin genes (GO:0016446)2.76397460
84somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76397460
85cellular extravasation (GO:0045123)2.75191511
86histone exchange (GO:0043486)2.73570526
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73385681
88regulation of B cell apoptotic process (GO:0002902)2.72217351
89granulocyte activation (GO:0036230)2.72041337
90spindle checkpoint (GO:0031577)2.71278328
91maturation of 5.8S rRNA (GO:0000460)2.70465247
92nucleotide-excision repair, DNA gap filling (GO:0006297)2.70408210
93nuclear envelope organization (GO:0006998)2.69992827
94regulation of interleukin-12 biosynthetic process (GO:0045075)2.69714590
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.69171993
96attachment of spindle microtubules to kinetochore (GO:0008608)2.68410828
97meiotic chromosome segregation (GO:0045132)2.67960315
98positive regulation of leukocyte apoptotic process (GO:2000108)2.67728064
997-methylguanosine mRNA capping (GO:0006370)2.67646594
100termination of RNA polymerase III transcription (GO:0006386)2.65586758
101transcription elongation from RNA polymerase III promoter (GO:0006385)2.65586758
102neutrophil activation involved in immune response (GO:0002283)2.65458457
103positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63891355
104RNA splicing, via transesterification reactions (GO:0000375)2.62868829
105regulation of necroptotic process (GO:0060544)2.62421250
106G1/S transition of mitotic cell cycle (GO:0000082)2.62169781
107cell cycle G1/S phase transition (GO:0044843)2.62169781
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62018100
109positive regulation of chromosome segregation (GO:0051984)2.61509749
110negative regulation of tumor necrosis factor production (GO:0032720)2.61384738
111mitotic sister chromatid segregation (GO:0000070)2.61151904
112RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.60942520
113mRNA splicing, via spliceosome (GO:0000398)2.60942520
114translational initiation (GO:0006413)2.60377519
115positive regulation of interleukin-1 secretion (GO:0050716)2.60279612
116transcription from RNA polymerase I promoter (GO:0006360)2.59526105
117oligosaccharide catabolic process (GO:0009313)2.59446032
118negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.59181178
119mitotic spindle checkpoint (GO:0071174)2.58641563
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.58479862
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.58479862
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.58479862
123negative regulation of sister chromatid segregation (GO:0033046)2.58479862
124regulation of interleukin-8 biosynthetic process (GO:0045414)2.58472525
125regulation of interleukin-1 beta secretion (GO:0050706)2.58119745
126negative regulation of chromosome segregation (GO:0051985)2.58113540
127regulation of necrotic cell death (GO:0010939)2.57816880
128RNA capping (GO:0036260)2.57655018
1297-methylguanosine RNA capping (GO:0009452)2.57655018
130telomere organization (GO:0032200)2.57587814
131chaperone mediated protein folding requiring cofactor (GO:0051085)2.57513084
132telomere maintenance (GO:0000723)2.57049140
133negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.56396931
134positive regulation of lymphocyte apoptotic process (GO:0070230)2.56239690
135spliceosomal complex assembly (GO:0000245)2.56001639
136tRNA methylation (GO:0030488)2.55510608
137regulation of vitamin metabolic process (GO:0030656)2.55494199
138positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.55175807
139regulation of mast cell activation (GO:0033003)2.54755531
140DNA synthesis involved in DNA repair (GO:0000731)2.54746496
141ribosomal small subunit biogenesis (GO:0042274)2.54599237
142positive regulation of defense response to virus by host (GO:0002230)2.54520461
143I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.53843017
144regulation of helicase activity (GO:0051095)2.53063100
145folic acid metabolic process (GO:0046655)2.52938950
146positive regulation of protein oligomerization (GO:0032461)2.50369737
147positive regulation of interleukin-2 production (GO:0032743)2.50267350
148positive regulation of heat generation (GO:0031652)2.48850564
149L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47101511
150positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.46655073
151mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.46655073
152detection of molecule of bacterial origin (GO:0032490)2.46235744
153positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45504151
154positive regulation of p38MAPK cascade (GO:1900745)2.44718643
155positive regulation of mitochondrial membrane permeability (GO:0035794)2.42749053
156negative regulation of cytokine production involved in immune response (GO:0002719)2.42425648
157regulation of mast cell degranulation (GO:0043304)2.42360816
158neutrophil activation (GO:0042119)2.40813622
159negative regulation of myeloid cell apoptotic process (GO:0033033)2.40476656
160positive regulation of NF-kappaB import into nucleus (GO:0042346)2.40319143
161negative regulation of inclusion body assembly (GO:0090084)2.39695677
162regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.39405972
163myeloid leukocyte mediated immunity (GO:0002444)2.37990175
164response to arsenic-containing substance (GO:0046685)2.37966075
165negative regulation of cell killing (GO:0031342)2.37160055
166negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37160055
167negative regulation of necroptotic process (GO:0060546)2.35756836
168regulation of defense response to virus by host (GO:0050691)2.35477733
169response to acidic pH (GO:0010447)2.34942011
170positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.34701482
171modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34635138
172modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34635138
173positive regulation by organism of defense response of other organism involved in symbiotic interact2.34635138
174modulation by symbiont of host immune response (GO:0052553)2.34635138
175positive regulation by symbiont of host defense response (GO:0052509)2.34635138
176modulation by symbiont of host defense response (GO:0052031)2.34635138
177B cell mediated immunity (GO:0019724)2.33933846
178regulation of myeloid cell apoptotic process (GO:0033032)2.33728663
179regulation of mast cell activation involved in immune response (GO:0033006)2.32893403
180regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.32098787
181regulation of B cell receptor signaling pathway (GO:0050855)2.30757957
182regulation of gamma-delta T cell activation (GO:0046643)2.30180134
183purine nucleotide salvage (GO:0032261)2.28980426
184natural killer cell activation involved in immune response (GO:0002323)2.28593478
1853-UTR-mediated mRNA stabilization (GO:0070935)2.28286410
186interferon-gamma production (GO:0032609)2.28088578
187nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.27547878
188regulation of interleukin-1 secretion (GO:0050704)2.23422967
189positive regulation of macrophage differentiation (GO:0045651)2.23124368
190macrophage activation involved in immune response (GO:0002281)2.22975150
191negative regulation of necrotic cell death (GO:0060547)2.22168088
192myeloid cell activation involved in immune response (GO:0002275)2.22058327
193regulation of type I interferon-mediated signaling pathway (GO:0060338)2.21868792
194leukocyte degranulation (GO:0043299)2.21276936
195regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.19618522
196cellular response to molecule of bacterial origin (GO:0071219)2.19571403
197regulation of inflammatory response to antigenic stimulus (GO:0002861)2.19568019
198positive regulation of interleukin-1 beta production (GO:0032731)2.18760100
199cellular response to lipopolysaccharide (GO:0071222)2.17807484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.45051443
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.25603219
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.04694885
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.63261514
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25995040
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20702311
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96083109
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92934120
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79764522
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77118689
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76673452
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.75996177
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72612881
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.70045151
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.65705105
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64383590
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62738079
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.61802046
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.61268580
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59861074
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57673446
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46912696
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35248977
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.24865076
25VDR_23849224_ChIP-Seq_CD4+_Human2.22806105
26* XRN2_22483619_ChIP-Seq_HELA_Human2.21099854
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19557161
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18280665
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13622834
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.13290292
31* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11582289
32VDR_24763502_ChIP-Seq_THP-1_Human2.09590486
33MAF_26560356_Chip-Seq_TH1_Human2.07990191
34MYB_26560356_Chip-Seq_TH2_Human2.02701383
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99483675
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97822339
37FOXP3_21729870_ChIP-Seq_TREG_Human1.96878738
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95877383
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90739988
40MAF_26560356_Chip-Seq_TH2_Human1.89560193
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87939332
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87889815
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87588023
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.87558234
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86849479
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85701626
47* GABP_19822575_ChIP-Seq_HepG2_Human1.82681460
48AR_21909140_ChIP-Seq_LNCAP_Human1.82472812
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82220734
50DCP1A_22483619_ChIP-Seq_HELA_Human1.81673971
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.79456195
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78421319
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77746822
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73857834
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.73732603
56UTX_26944678_Chip-Seq_JUKART_Human1.72892358
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71563937
58ELK1_19687146_ChIP-ChIP_HELA_Human1.69650834
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67643429
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67623843
61MYB_26560356_Chip-Seq_TH1_Human1.66817724
62MYC_22102868_ChIP-Seq_BL_Human1.65562119
63TTF2_22483619_ChIP-Seq_HELA_Human1.64894088
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.64490731
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63316058
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61858380
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59970787
68CIITA_25753668_ChIP-Seq_RAJI_Human1.58576929
69* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.56220098
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53547125
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52159352
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51369395
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51054683
74* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49890363
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49556772
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49503953
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48329237
78KDM5A_27292631_Chip-Seq_BREAST_Human1.44503032
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44055863
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.43124909
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.42703086
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.42149835
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.41998947
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40441260
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.39801294
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38768872
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.38526534
88CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37992762
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37614372
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37166728
91SPI1_23127762_ChIP-Seq_K562_Human1.35382086
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33188743
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32152920
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32130403
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31530586
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29544881
97KDM2B_26808549_Chip-Seq_DND41_Human1.27726867
98RUNX_20019798_ChIP-Seq_JUKART_Human1.27023207
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25498389
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23912311
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22865638
102TCF7_22412390_ChIP-Seq_EML_Mouse1.21809267
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20885027
104TFEB_21752829_ChIP-Seq_HELA_Human1.20078348
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19986972
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19277048
107FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19010458
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18621878
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18318175
110* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18160867
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17939239
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17712266
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.17556009
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17365608
115* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16183961
116* ATF3_27146783_Chip-Seq_COLON_Human1.16116574
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15787732
118GATA3_27048872_Chip-Seq_THYMUS_Human1.14966786
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14523142
120GATA3_26560356_Chip-Seq_TH2_Human1.14471795
121BCOR_27268052_Chip-Seq_Bcells_Human1.11845241
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11822604
123* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11202073
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11058334
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10953480
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10849354
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10618558
128KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10137687
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09761253
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09405445
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09215647
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08782912
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08305480
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07478526
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07447505
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07394251
137VDR_24787735_ChIP-Seq_THP-1_Human1.07171110
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06968387
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06874423
140BCL6_27268052_Chip-Seq_Bcells_Human1.06382143
141GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05521679
142GATA1_19941827_ChIP-Seq_MEL_Mouse1.05151459
143* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04935079
144CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04310521
145SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03291162
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01289248
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99733275
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98057987
149SPI1_23547873_ChIP-Seq_NB4_Human0.98022072
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95445979
151CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94251408
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93760581
153* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93528695
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92645314
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.89856912
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88707841
157VDR_21846776_ChIP-Seq_THP-1_Human0.88379363
158MYC_18940864_ChIP-ChIP_HL60_Human0.85026376
159NANOG_21062744_ChIP-ChIP_HESCs_Human0.84264582
160NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81588403
161IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80996100
162CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78192806
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77748049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.61031661
2MP0003111_abnormal_nucleus_morphology3.74113791
3MP0010094_abnormal_chromosome_stability3.64163702
4MP0003077_abnormal_cell_cycle3.42599801
5MP0003646_muscle_fatigue3.26651385
6MP0004957_abnormal_blastocyst_morpholog3.18375973
7MP0003303_peritoneal_inflammation3.06961372
8MP0008007_abnormal_cellular_replicative2.86388234
9MP0008058_abnormal_DNA_repair2.78324336
10MP0008057_abnormal_DNA_replication2.76810756
11MP0009840_abnormal_foam_cell2.73540027
12MP0003123_paternal_imprinting2.58206360
13MP0002148_abnormal_hypersensitivity_rea2.50522278
14MP0005000_abnormal_immune_tolerance2.33357047
15MP0004510_myositis2.27636440
16MP0009785_altered_susceptibility_to2.26089909
17MP0008932_abnormal_embryonic_tissue2.20876439
18MP0003724_increased_susceptibility_to2.18449715
19* MP0002419_abnormal_innate_immunity2.14857785
20MP0010352_gastrointestinal_tract_polyps2.06062106
21MP0002723_abnormal_immune_serum2.06032853
22MP0001730_embryonic_growth_arrest2.02947605
23MP0002332_abnormal_exercise_endurance2.01715981
24MP0005025_abnormal_response_to1.97985201
25MP0006082_CNS_inflammation1.96844733
26MP0002396_abnormal_hematopoietic_system1.96145129
27MP0001800_abnormal_humoral_immune1.95972781
28MP0001835_abnormal_antigen_presentation1.93142668
29MP0010030_abnormal_orbit_morphology1.92184412
30MP0002837_dystrophic_cardiac_calcinosis1.91749438
31MP0005058_abnormal_lysosome_morphology1.90208790
32MP0000350_abnormal_cell_proliferation1.86530933
33* MP0002452_abnormal_antigen_presenting1.83472670
34MP0003786_premature_aging1.80816962
35MP0009764_decreased_sensitivity_to1.78563990
36MP0003567_abnormal_fetal_cardiomyocyte1.76173821
37* MP0001819_abnormal_immune_cell1.74537820
38MP0003656_abnormal_erythrocyte_physiolo1.70842314
39MP0005380_embryogenesis_phenotype1.68724000
40MP0001672_abnormal_embryogenesis/_devel1.68724000
41MP0000749_muscle_degeneration1.68675802
42MP0005330_cardiomyopathy1.67827264
43MP0004233_abnormal_muscle_weight1.67366593
44MP0004808_abnormal_hematopoietic_stem1.67215361
45MP0008877_abnormal_DNA_methylation1.66420095
46MP0010307_abnormal_tumor_latency1.61623788
47MP0003984_embryonic_growth_retardation1.60966788
48MP0006036_abnormal_mitochondrial_physio1.58104303
49MP0002088_abnormal_embryonic_growth/wei1.56254956
50MP0001697_abnormal_embryo_size1.55530355
51MP0003121_genomic_imprinting1.55450738
52MP0001853_heart_inflammation1.55297023
53MP0005387_immune_system_phenotype1.55049542
54MP0001790_abnormal_immune_system1.55049542
55MP0004947_skin_inflammation1.52676772
56MP0008260_abnormal_autophagy1.48895106
57MP0000343_altered_response_to1.46950572
58MP0000750_abnormal_muscle_regeneration1.46801354
59MP0003172_abnormal_lysosome_physiology1.46633385
60MP0002877_abnormal_melanocyte_morpholog1.45246305
61MP0001845_abnormal_inflammatory_respons1.43916757
62MP0005310_abnormal_salivary_gland1.40275667
63MP0002080_prenatal_lethality1.40239921
64MP0000490_abnormal_crypts_of1.38882567
65MP0002086_abnormal_extraembryonic_tissu1.38623533
66MP0003075_altered_response_to1.34100646
67MP0009333_abnormal_splenocyte_physiolog1.33376332
68MP0004484_altered_response_of1.30472886
69MP0008469_abnormal_protein_level1.29455433
70MP0000015_abnormal_ear_pigmentation1.28698445
71MP0000685_abnormal_immune_system1.28623754
72MP0003300_gastrointestinal_ulcer1.27655513
73MP0002085_abnormal_embryonic_tissue1.27227707
74* MP0000313_abnormal_cell_death1.27149013
75MP0003718_maternal_effect1.26311977
76* MP0004197_abnormal_fetal_growth/weight/1.25480296
77MP0003763_abnormal_thymus_physiology1.25294707
78MP0002084_abnormal_developmental_patter1.18826225
79MP0005464_abnormal_platelet_physiology1.18798722
80MP0005670_abnormal_white_adipose1.18779054
81MP0001533_abnormal_skeleton_physiology1.16560210
82MP0004036_abnormal_muscle_relaxation1.14477865
83MP0002019_abnormal_tumor_incidence1.14378431
84* MP0001293_anophthalmia1.13992295
85MP0002210_abnormal_sex_determination1.10193345
86MP0000747_muscle_weakness1.04295360
87MP0005410_abnormal_fertilization1.01417205
88MP0004145_abnormal_muscle_electrophysio1.01416411
89MP0005408_hypopigmentation1.01031814
90MP0002269_muscular_atrophy1.00524954
91MP0002160_abnormal_reproductive_system1.00170901
92MP0004084_abnormal_cardiac_muscle0.99891030
93MP0002938_white_spotting0.99591989
94* MP0000703_abnormal_thymus_morphology0.98442216
95MP0003705_abnormal_hypodermis_morpholog0.97945301
96MP0009697_abnormal_copulation0.97397751
97MP0003221_abnormal_cardiomyocyte_apopto0.97095760
98MP0002398_abnormal_bone_marrow0.96842620
99MP0003950_abnormal_plasma_membrane0.96709438
100MP0005023_abnormal_wound_healing0.95180743
101MP0001119_abnormal_female_reproductive0.94263631
102MP0003943_abnormal_hepatobiliary_system0.93885131
103MP0005671_abnormal_response_to0.93601744
104MP0001929_abnormal_gametogenesis0.93571129
105MP0003890_abnormal_embryonic-extraembry0.93350043
106MP0006054_spinal_hemorrhage0.93293541
107MP0009672_abnormal_birth_weight0.92913441
108MP0004087_abnormal_muscle_fiber0.92751236
109MP0003828_pulmonary_edema0.92700221
110MP0001986_abnormal_taste_sensitivity0.92544499
111MP0004130_abnormal_muscle_cell0.92536998
112MP0001545_abnormal_hematopoietic_system0.92155476
113MP0005397_hematopoietic_system_phenotyp0.92155476
114MP0001915_intracranial_hemorrhage0.91744848
115MP0005083_abnormal_biliary_tract0.91024270
116MP0002998_abnormal_bone_remodeling0.90669648
117MP0002127_abnormal_cardiovascular_syste0.89530461
118MP0000689_abnormal_spleen_morphology0.89457807
119MP0001145_abnormal_male_reproductive0.89372990
120MP0002693_abnormal_pancreas_physiology0.89128507
121* MP0002722_abnormal_immune_system0.88959093
122MP0002106_abnormal_muscle_physiology0.88403199
123MP0006035_abnormal_mitochondrial_morpho0.88263563
124MP0002653_abnormal_ependyma_morphology0.87846309
125MP0000371_diluted_coat_color0.87402661
126MP0003315_abnormal_perineum_morphology0.87158406
127MP0000372_irregular_coat_pigmentation0.87061412
128MP0000759_abnormal_skeletal_muscle0.85283672
129MP0005166_decreased_susceptibility_to0.84689617
130MP0001501_abnormal_sleep_pattern0.84576100
131MP0000858_altered_metastatic_potential0.84385613
132MP0005266_abnormal_metabolism0.83305900
133MP0003045_fibrosis0.82751236
134MP0000569_abnormal_digit_pigmentation0.82546937
135MP0001502_abnormal_circadian_rhythm0.81646565
136MP0002138_abnormal_hepatobiliary_system0.81093263
137MP0003566_abnormal_cell_adhesion0.80780792
138MP0000653_abnormal_sex_gland0.80589019
139MP0008004_abnormal_stomach_pH0.79875459
140MP0003937_abnormal_limbs/digits/tail_de0.79015095
141MP0002972_abnormal_cardiac_muscle0.79008118
142MP0004215_abnormal_myocardial_fiber0.77936077
143MP0000751_myopathy0.77744888
144MP0000604_amyloidosis0.76866713
145MP0005584_abnormal_enzyme/coenzyme_acti0.76546210
146* MP0002429_abnormal_blood_cell0.76519800
147MP0003186_abnormal_redox_activity0.75823152
148MP0009763_increased_sensitivity_to0.75064848
149MP0009053_abnormal_anal_canal0.75060811
150MP0000537_abnormal_urethra_morphology0.74816552
151MP0002405_respiratory_system_inflammati0.74781965
152MP0003195_calcinosis0.74710144
153MP0010155_abnormal_intestine_physiology0.74384781
154* MP0002092_abnormal_eye_morphology0.72910813
155MP0005389_reproductive_system_phenotype0.72661536
156MP0002111_abnormal_tail_morphology0.72212791
157MP0000358_abnormal_cell_content/0.71741289
158MP0002925_abnormal_cardiovascular_devel0.71338798
159MP0003119_abnormal_digestive_system0.69610373
160MP0005384_cellular_phenotype0.67798425
161MP0001186_pigmentation_phenotype0.66073008
162MP0003941_abnormal_skin_development0.65006623
163MP0009278_abnormal_bone_marrow0.64971847
164MP0000716_abnormal_immune_system0.64678943
165MP0005451_abnormal_body_composition0.64592205
166MP0001286_abnormal_eye_development0.64538611
167MP0002075_abnormal_coat/hair_pigmentati0.63379134
168MP0005621_abnormal_cell_physiology0.62412835
169MP0005076_abnormal_cell_differentiation0.61982809
170MP0003806_abnormal_nucleotide_metabolis0.60944046
171MP0003436_decreased_susceptibility_to0.60551256
172MP0000767_abnormal_smooth_muscle0.58914494
173MP0004133_heterotaxia0.58613675
174* MP0002420_abnormal_adaptive_immunity0.58417052
175MP0000516_abnormal_urinary_system0.57846672

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.39273697
2Stomatitis (HP:0010280)4.21848617
3Birth length less than 3rd percentile (HP:0003561)4.12754079
4Abnormality of macrophages (HP:0004311)3.84970606
5Myositis (HP:0100614)3.60094807
6Optic neuritis (HP:0100653)3.58843130
7Retrobulbar optic neuritis (HP:0100654)3.58843130
8Orchitis (HP:0100796)3.52938840
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.49724143
10Degeneration of anterior horn cells (HP:0002398)3.48552350
11Abnormality of the anterior horn cell (HP:0006802)3.48552350
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.47287602
13Abnormality of glycolipid metabolism (HP:0010969)3.47287602
14Abnormality of liposaccharide metabolism (HP:0010968)3.47287602
15Chromsome breakage (HP:0040012)3.40162274
16Breast hypoplasia (HP:0003187)3.30018885
17Reticulocytopenia (HP:0001896)3.29256027
18Increased cerebral lipofuscin (HP:0011813)3.22126362
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.15153736
20Autoimmune thrombocytopenia (HP:0001973)3.13789771
21Patellar aplasia (HP:0006443)3.08334642
22Aplastic anemia (HP:0001915)3.07963549
23Rhabdomyolysis (HP:0003201)3.02344942
24Aplasia/Hypoplasia of the patella (HP:0006498)2.98281959
25Amyloidosis (HP:0011034)2.95535314
26Carpal bone hypoplasia (HP:0001498)2.95530761
2711 pairs of ribs (HP:0000878)2.86674359
28Colon cancer (HP:0003003)2.84015003
29Abnormality of cells of the erythroid lineage (HP:0012130)2.81931902
30Abnormal number of erythroid precursors (HP:0012131)2.78468929
31Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77703034
32Meckel diverticulum (HP:0002245)2.75722890
33Selective tooth agenesis (HP:0001592)2.70718174
34Mediastinal lymphadenopathy (HP:0100721)2.69870767
35Syringomyelia (HP:0003396)2.64359105
36Spinal cord lesions (HP:0100561)2.64359105
37Recurrent bacterial skin infections (HP:0005406)2.63171268
38Progressive muscle weakness (HP:0003323)2.62592347
39Impulsivity (HP:0100710)2.62537084
40Vacuolated lymphocytes (HP:0001922)2.61406961
41Abnormality of the ileum (HP:0001549)2.61357996
42Increased serum ferritin (HP:0003281)2.60577679
43Gastrointestinal infarctions (HP:0005244)2.59573995
44Fatigue (HP:0012378)2.58776633
45Medulloblastoma (HP:0002885)2.56568546
46Recurrent abscess formation (HP:0002722)2.52861301
47Myoglobinuria (HP:0002913)2.51413867
48Abnormality of chromosome stability (HP:0003220)2.49674897
49Abnormality of the preputium (HP:0100587)2.46037294
50Episodic fever (HP:0001954)2.45184816
51Cerebral hypomyelination (HP:0006808)2.43754812
52Rough bone trabeculation (HP:0100670)2.43254129
53Absent thumb (HP:0009777)2.42812811
54Upper limb muscle weakness (HP:0003484)2.41926159
55Loss of speech (HP:0002371)2.41675753
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.41044326
57Cholecystitis (HP:0001082)2.38972458
58Abnormal gallbladder physiology (HP:0012438)2.38972458
59Ragged-red muscle fibers (HP:0003200)2.37390656
60Premature graying of hair (HP:0002216)2.36786986
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.33091534
62Myelodysplasia (HP:0002863)2.33058990
63Keratoconjunctivitis sicca (HP:0001097)2.33028923
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30985730
65Chronic obstructive pulmonary disease (HP:0006510)2.30751013
66Obstructive lung disease (HP:0006536)2.30751013
67Acute hepatic failure (HP:0006554)2.30440130
68Muscle fiber inclusion bodies (HP:0100299)2.28805220
69Abnormality of the umbilical cord (HP:0010881)2.28308626
70Ectopic kidney (HP:0000086)2.27580325
71Abnormality of the calcaneus (HP:0008364)2.26101709
72EMG: myopathic abnormalities (HP:0003458)2.23165113
73Absent radius (HP:0003974)2.22416149
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20498109
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20498109
76Abnormality of polysaccharide metabolism (HP:0011012)2.20498109
77Pulmonary infiltrates (HP:0002113)2.18387595
78Bone marrow hypocellularity (HP:0005528)2.18332437
79Abnormal lung lobation (HP:0002101)2.18081303
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.15699937
81Abnormality of the fetal cardiovascular system (HP:0010948)2.15038156
82Abnormal umbilical cord blood vessels (HP:0011403)2.15038156
83Single umbilical artery (HP:0001195)2.15038156
84Generalized aminoaciduria (HP:0002909)2.11881676
85Nausea (HP:0002018)2.11227669
86Abnormality of transition element cation homeostasis (HP:0011030)2.09827181
87Nemaline bodies (HP:0003798)2.09611932
88Neoplasm of the pancreas (HP:0002894)2.08929054
89Vasculitis (HP:0002633)2.08691757
90Abnormality of iron homeostasis (HP:0011031)2.06918305
91Granulocytopenia (HP:0001913)2.06344752
92Sloping forehead (HP:0000340)2.05932715
93Keratoconjunctivitis (HP:0001096)2.05166153
94Dysostosis multiplex (HP:0000943)2.04649932
95Aplasia involving forearm bones (HP:0009822)2.04320150
96Absent forearm bone (HP:0003953)2.04320150
97Trismus (HP:0000211)2.04089890
98Thrombocytosis (HP:0001894)2.03974382
99Polyneuropathy (HP:0001271)2.03914710
100Myopathic facies (HP:0002058)2.03029223
101Duodenal stenosis (HP:0100867)2.02631476
102Small intestinal stenosis (HP:0012848)2.02631476
103Abnormality of the endocardium (HP:0004306)2.00760079
104Encephalitis (HP:0002383)2.00254615
105Diaphragmatic weakness (HP:0009113)1.99760541
106Hemoptysis (HP:0002105)1.98251714
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97996379
108Muscle fiber splitting (HP:0003555)1.96731978
109Amaurosis fugax (HP:0100576)1.96426724
110Supernumerary spleens (HP:0009799)1.96009179
111Ependymoma (HP:0002888)1.95562590
112Basal cell carcinoma (HP:0002671)1.94668853
113Abnormality of glycolysis (HP:0004366)1.93903291
114Keratitis (HP:0000491)1.93658735
115Increased IgM level (HP:0003496)1.93175226
116Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92631468
117Abnormality of alanine metabolism (HP:0010916)1.92631468
118Hyperalaninemia (HP:0003348)1.92631468
119Cutaneous melanoma (HP:0012056)1.91838413
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91598907
121Frequent falls (HP:0002359)1.91355450
122Neuronal loss in central nervous system (HP:0002529)1.91338990
123Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90783028
124Increased serum pyruvate (HP:0003542)1.90161003
125Leukocytosis (HP:0001974)1.89950387
126Optic nerve coloboma (HP:0000588)1.89355362
127Horseshoe kidney (HP:0000085)1.87699860
128Agnosia (HP:0010524)1.87495752
129Microretrognathia (HP:0000308)1.87180434
130Recurrent fungal infections (HP:0002841)1.87142229
131Glossoptosis (HP:0000162)1.87060848
132Progressive external ophthalmoplegia (HP:0000590)1.86255625
133Chest pain (HP:0100749)1.85836126
134Autoimmune hemolytic anemia (HP:0001890)1.85827119
135Exercise-induced myalgia (HP:0003738)1.85426403
136Increased CSF protein (HP:0002922)1.84993237
137Mutism (HP:0002300)1.84542043
138Ureteral duplication (HP:0000073)1.84343716
139Supraventricular tachycardia (HP:0004755)1.84302676
140Hypoplasia of the radius (HP:0002984)1.83662445
141Facial cleft (HP:0002006)1.83023939
142Petechiae (HP:0000967)1.82895198
143Disinhibition (HP:0000734)1.82471926
144Oral leukoplakia (HP:0002745)1.81912953
145Atresia of the external auditory canal (HP:0000413)1.81372327
146Abnormality of the carotid arteries (HP:0005344)1.80969734
147Short thumb (HP:0009778)1.80893339
148Prolonged neonatal jaundice (HP:0006579)1.80876444
149Tracheoesophageal fistula (HP:0002575)1.80719337
150Hepatic necrosis (HP:0002605)1.80240496
151Multiple enchondromatosis (HP:0005701)1.80178462
152Deviation of the thumb (HP:0009603)1.79757878
153Rhabdomyosarcoma (HP:0002859)1.79521990
154Slender long bone (HP:0003100)1.79166721
155Asymmetric septal hypertrophy (HP:0001670)1.79128831
156Missing ribs (HP:0000921)1.78894570
157Supraventricular arrhythmia (HP:0005115)1.77564495
158Progressive microcephaly (HP:0000253)1.76898486
159Sparse lateral eyebrow (HP:0005338)1.76395045
160Primary atrial arrhythmia (HP:0001692)1.76048726
161Eczematoid dermatitis (HP:0000976)1.75542416
162Arterial thrombosis (HP:0004420)1.75330122
163Abnormality of T cell physiology (HP:0011840)1.74585004
164Bundle branch block (HP:0011710)1.74041295
165Eosinophilia (HP:0001880)1.73980450
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73564479
167Pallor (HP:0000980)1.72830142
168Muscle fibrillation (HP:0010546)1.72730910
169Abnormal glycosylation (HP:0012345)1.72679936
170Abnormal protein N-linked glycosylation (HP:0012347)1.72679936
171Entropion (HP:0000621)1.72599024
172Secondary amenorrhea (HP:0000869)1.72505235
173Short 4th metacarpal (HP:0010044)1.71275929
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71275929
175Stillbirth (HP:0003826)1.71273704
176Abnormality of reticulocytes (HP:0004312)1.71070445
177Calcaneovalgus deformity (HP:0001848)1.70928781
178Muscle fiber atrophy (HP:0100295)1.69007450
179Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66668307
180Triphalangeal thumb (HP:0001199)1.66605093
181Type 2 muscle fiber atrophy (HP:0003554)1.66500833
182Duplicated collecting system (HP:0000081)1.65814036
183Type I transferrin isoform profile (HP:0003642)1.65588059
184Premature ovarian failure (HP:0008209)1.65564285
185Lymphoma (HP:0002665)1.65561639
186Abnormal trabecular bone morphology (HP:0100671)1.65398096
187Spinal muscular atrophy (HP:0007269)1.65236021
188Increased nuchal translucency (HP:0010880)1.65160719
189Prominent nose (HP:0000448)1.65009095
190Proximal placement of thumb (HP:0009623)1.63965969
191Abnormality of the duodenum (HP:0002246)1.62606413
192Absent epiphyses (HP:0010577)1.61409599
193Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61409599
194Abnormal number of incisors (HP:0011064)1.61378540
195Macrocytic anemia (HP:0001972)1.59578061
196Cellular immunodeficiency (HP:0005374)1.58660054
197Deformed tarsal bones (HP:0008119)1.58017977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.06126343
2WEE13.09505331
3TSSK62.83538060
4CDC72.72976032
5PLK42.63795312
6TAOK32.54631160
7BRSK22.47175432
8NEK22.31745828
9TBK12.17575391
10SRPK12.16382121
11EIF2AK12.11191582
12MAP3K132.01347602
13EIF2AK31.99081306
14ZAK1.94884163
15MKNK11.93024961
16NME21.92374277
17TTK1.90320271
18MKNK21.85145024
19BRD41.84768551
20PLK11.84425462
21CDK121.80685728
22RPS6KA41.80448401
23SIK21.73812950
24MOS1.72902604
25ACVR1B1.69041484
26PASK1.68096665
27PINK11.59354229
28STK38L1.55009787
29CDK71.50236422
30EPHA21.48162536
31ATR1.48083638
32PLK31.48064083
33IRAK11.48043367
34IKBKE1.44007076
35VRK11.43524351
36AURKB1.38750946
37TTN1.36576008
38BCKDK1.36158598
39MAP2K31.32840890
40BRSK11.32228011
41DYRK31.30655554
42STK101.29329333
43IRAK21.27769693
44STK41.25176936
45MAP3K51.24782649
46CHEK21.24769560
47GRK71.23974067
48TESK21.21167563
49TLK11.20953062
50STK161.20255316
51RPS6KB21.19999322
52PRPF4B1.19957543
53CDK41.19598485
54TESK11.17390186
55FRK1.15186046
56NEK11.13911678
57ARAF1.13551772
58MAP2K61.13446454
59SIK31.08504613
60ERN11.06917586
61MARK31.06045557
62KSR21.05449357
63CHEK11.04302595
64PIM11.01440340
65RAF11.01002476
66AURKA1.00717575
67MAP4K11.00022395
68MAP3K10.99824401
69MAP3K80.99389572
70MAP3K30.98036022
71MAP3K100.96951940
72KDR0.95353078
73IRAK30.94454584
74TRPM70.92732650
75PIM20.92536591
76MAP3K140.91988182
77CLK10.91405975
78TGFBR10.90381976
79FES0.87571750
80PKN20.86668344
81LATS20.84805896
82EEF2K0.84359120
83BMPR20.83542844
84MAPK110.83481174
85EIF2AK20.83248468
86TXK0.82724072
87ABL20.80443902
88FLT30.79681327
89STK30.79572394
90CSK0.77984929
91ZAP700.77962656
92CHUK0.76139087
93AKT30.75941279
94NEK90.75156256
95RIPK40.74520385
96PAK40.72568813
97CDK20.70429243
98ATM0.70072180
99ITK0.69871647
100SYK0.67954262
101PDK10.67072777
102HCK0.65438098
103MAPK120.63253709
104JAK30.61477370
105OBSCN0.61329852
106RPS6KA10.61170338
107MELK0.60961037
108TAOK10.58701659
109CDK80.57995976
110PAK10.57963604
111RPS6KC10.57501540
112RPS6KL10.57501540
113CSNK2A10.56517830
114ADRBK20.56366906
115ALK0.55402417
116RPS6KA50.54437197
117BRAF0.54398405
118BTK0.53679275
119RPS6KA60.53632137
120IKBKB0.53053923
121PDPK10.52646098
122LATS10.51806323
123PAK60.51712946
124CSNK2A20.51348461
125CAMK40.50955899
126KSR10.50665931
127PIK3CG0.50075489
128LCK0.49542037
129MAP3K90.49369327
130MARK20.48433351
131PRKCQ0.47964824
132JAK20.47785523
133TEC0.47588814
134LYN0.47204588
135NLK0.47076635
136TNK20.46555166
137SCYL20.46516561
138MTOR0.45467568
139CCNB10.45253652
140ERBB30.44941453
141CDK10.44927488
142MAP3K60.43586647
143PHKG10.43585263
144PHKG20.43585263
145CDK90.43568962
146PRKCI0.41708672
147TYK20.41704618
148BLK0.41696610
149LRRK20.40013413
150IRAK40.39970981
151MAP3K20.39942412
152MAP3K110.39137629
153TAOK20.38524078
154TGFBR20.37991142
155CAMKK20.36239997
156MAPKAPK30.35868869
157TIE10.35851236
158NEK60.35387519
159PDK20.35279118
160STK240.34849565
161PAK20.34563464
162PRKAA20.33945769
163KIT0.32777860
164PRKAA10.32146906
165PBK0.31692463
166MATK0.30319657

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.96360190
2Mismatch repair_Homo sapiens_hsa034303.60853456
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.56207750
4RNA polymerase_Homo sapiens_hsa030203.40642634
5Spliceosome_Homo sapiens_hsa030402.96782904
6RNA transport_Homo sapiens_hsa030132.94757826
7Proteasome_Homo sapiens_hsa030502.87408141
8Base excision repair_Homo sapiens_hsa034102.84583650
9Ribosome_Homo sapiens_hsa030102.63201385
10Cell cycle_Homo sapiens_hsa041102.53370245
11Homologous recombination_Homo sapiens_hsa034402.52334236
12Nucleotide excision repair_Homo sapiens_hsa034202.43237085
13Osteoclast differentiation_Homo sapiens_hsa043802.38443650
14One carbon pool by folate_Homo sapiens_hsa006702.25318013
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23361499
16Pyrimidine metabolism_Homo sapiens_hsa002402.21941410
17Rheumatoid arthritis_Homo sapiens_hsa053232.20532461
18Basal transcription factors_Homo sapiens_hsa030222.19664717
19Fanconi anemia pathway_Homo sapiens_hsa034602.19353729
20Other glycan degradation_Homo sapiens_hsa005112.11032240
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07078676
22RNA degradation_Homo sapiens_hsa030181.99576487
23Tuberculosis_Homo sapiens_hsa051521.83872858
24mRNA surveillance pathway_Homo sapiens_hsa030151.81135416
25p53 signaling pathway_Homo sapiens_hsa041151.65355336
26Lysosome_Homo sapiens_hsa041421.64690825
27Non-homologous end-joining_Homo sapiens_hsa034501.63728131
28Salmonella infection_Homo sapiens_hsa051321.62780788
29T cell receptor signaling pathway_Homo sapiens_hsa046601.47808226
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47710601
31Autoimmune thyroid disease_Homo sapiens_hsa053201.45453293
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43672812
33Type I diabetes mellitus_Homo sapiens_hsa049401.42037677
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40914555
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39128642
36Epstein-Barr virus infection_Homo sapiens_hsa051691.36750443
37B cell receptor signaling pathway_Homo sapiens_hsa046621.29938237
38Purine metabolism_Homo sapiens_hsa002301.29430903
39Malaria_Homo sapiens_hsa051441.29132290
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27370052
41Antigen processing and presentation_Homo sapiens_hsa046121.26088913
42Herpes simplex infection_Homo sapiens_hsa051681.22872715
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21665721
44Staphylococcus aureus infection_Homo sapiens_hsa051501.17394080
45Legionellosis_Homo sapiens_hsa051341.14631475
46Pertussis_Homo sapiens_hsa051331.10794629
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.08648940
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08333728
49Circadian rhythm_Homo sapiens_hsa047101.01393640
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.01315026
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99772274
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.98543993
53Prion diseases_Homo sapiens_hsa050200.98536572
54Protein export_Homo sapiens_hsa030600.97525607
55Systemic lupus erythematosus_Homo sapiens_hsa053220.97092641
56Viral carcinogenesis_Homo sapiens_hsa052030.96140142
57Pentose phosphate pathway_Homo sapiens_hsa000300.92048006
58Collecting duct acid secretion_Homo sapiens_hsa049660.90207687
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89258647
60HTLV-I infection_Homo sapiens_hsa051660.89137021
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85582049
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85119921
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.84569144
64MAPK signaling pathway_Homo sapiens_hsa040100.84448728
65Thyroid cancer_Homo sapiens_hsa052160.83230583
66Galactose metabolism_Homo sapiens_hsa000520.83050526
67VEGF signaling pathway_Homo sapiens_hsa043700.82570045
68Measles_Homo sapiens_hsa051620.82221922
69Vitamin B6 metabolism_Homo sapiens_hsa007500.81456863
70Chemokine signaling pathway_Homo sapiens_hsa040620.79296474
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77071094
72Hepatitis C_Homo sapiens_hsa051600.74859202
73MicroRNAs in cancer_Homo sapiens_hsa052060.73683170
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73196251
75African trypanosomiasis_Homo sapiens_hsa051430.72305315
76Notch signaling pathway_Homo sapiens_hsa043300.71594096
77Small cell lung cancer_Homo sapiens_hsa052220.71360387
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.70746597
79Dorso-ventral axis formation_Homo sapiens_hsa043200.70720755
80Type II diabetes mellitus_Homo sapiens_hsa049300.70466352
81Fructose and mannose metabolism_Homo sapiens_hsa000510.70208327
82Primary immunodeficiency_Homo sapiens_hsa053400.69489868
83Biosynthesis of amino acids_Homo sapiens_hsa012300.69426919
84Phagosome_Homo sapiens_hsa041450.68858029
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67811399
86Regulation of autophagy_Homo sapiens_hsa041400.67802799
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65485440
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64015075
89Endocytosis_Homo sapiens_hsa041440.63487080
90Vibrio cholerae infection_Homo sapiens_hsa051100.61431847
91HIF-1 signaling pathway_Homo sapiens_hsa040660.60970443
92Apoptosis_Homo sapiens_hsa042100.60886718
93Selenocompound metabolism_Homo sapiens_hsa004500.60751698
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58594592
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58459437
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.57554024
97Oocyte meiosis_Homo sapiens_hsa041140.56573850
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56482239
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55885734
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.54495084
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.50972146
102mTOR signaling pathway_Homo sapiens_hsa041500.50437060
103Hematopoietic cell lineage_Homo sapiens_hsa046400.50386167
104TGF-beta signaling pathway_Homo sapiens_hsa043500.49584947
105Influenza A_Homo sapiens_hsa051640.49126906
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49034450
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48347570
108Shigellosis_Homo sapiens_hsa051310.48181902
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47646953
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47264256
111Folate biosynthesis_Homo sapiens_hsa007900.46878323
112Insulin resistance_Homo sapiens_hsa049310.46415454
113Hepatitis B_Homo sapiens_hsa051610.45633442
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45618727
115Allograft rejection_Homo sapiens_hsa053300.44142851
116Leishmaniasis_Homo sapiens_hsa051400.44045374
117Insulin signaling pathway_Homo sapiens_hsa049100.43805338
118Hippo signaling pathway_Homo sapiens_hsa043900.43541830
119Chronic myeloid leukemia_Homo sapiens_hsa052200.42410245
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41973324
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.40873552
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40796563
123Adherens junction_Homo sapiens_hsa045200.40050863
124Renal cell carcinoma_Homo sapiens_hsa052110.39714753
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39479030
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39448415
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38742035
128Cardiac muscle contraction_Homo sapiens_hsa042600.37310623
129Graft-versus-host disease_Homo sapiens_hsa053320.36805308
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36774349
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36772839
132Vitamin digestion and absorption_Homo sapiens_hsa049770.36190599
133Arachidonic acid metabolism_Homo sapiens_hsa005900.35429967
134Acute myeloid leukemia_Homo sapiens_hsa052210.35018258
135Synaptic vesicle cycle_Homo sapiens_hsa047210.34697648
136Basal cell carcinoma_Homo sapiens_hsa052170.34693433
137Carbon metabolism_Homo sapiens_hsa012000.33756582
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33489815
139Viral myocarditis_Homo sapiens_hsa054160.32829696
140Prolactin signaling pathway_Homo sapiens_hsa049170.32043701
141Bladder cancer_Homo sapiens_hsa052190.31665399
142Colorectal cancer_Homo sapiens_hsa052100.30672365
143Toxoplasmosis_Homo sapiens_hsa051450.29105012
144Prostate cancer_Homo sapiens_hsa052150.27457674
145N-Glycan biosynthesis_Homo sapiens_hsa005100.26788806
146FoxO signaling pathway_Homo sapiens_hsa040680.26677966
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.26415163
148TNF signaling pathway_Homo sapiens_hsa046680.25797277
149Asthma_Homo sapiens_hsa053100.24365379
150Pathways in cancer_Homo sapiens_hsa052000.24042420
151Huntingtons disease_Homo sapiens_hsa050160.22601901
152Glutathione metabolism_Homo sapiens_hsa004800.21778040
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21174021
154Sulfur relay system_Homo sapiens_hsa041220.21067445
155Cyanoamino acid metabolism_Homo sapiens_hsa004600.20905796
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20137451
157Linoleic acid metabolism_Homo sapiens_hsa005910.19395557

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