JMJD7-PLA2G4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.39145027
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.39145027
3positive regulation of gamma-delta T cell activation (GO:0046645)5.33804264
4negative thymic T cell selection (GO:0045060)4.70362117
5negative T cell selection (GO:0043383)4.63559229
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43446887
7regulation of gamma-delta T cell activation (GO:0046643)4.38928229
8positive thymic T cell selection (GO:0045059)4.32412758
9regulation of gamma-delta T cell differentiation (GO:0045586)4.30697311
10thymic T cell selection (GO:0045061)4.28069829
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19808480
12antigen processing and presentation of endogenous antigen (GO:0019883)4.18186534
13negative regulation of erythrocyte differentiation (GO:0045647)4.15048359
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03583430
15activated T cell proliferation (GO:0050798)4.01996887
16T cell selection (GO:0045058)3.99554385
17positive T cell selection (GO:0043368)3.98517600
18mannose metabolic process (GO:0006013)3.79837349
19leukocyte aggregation (GO:0070486)3.79558689
20negative regulation of T cell mediated immunity (GO:0002710)3.72289973
21negative regulation of lymphocyte mediated immunity (GO:0002707)3.71548334
22negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.68044832
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.65511969
24regulation of ARF protein signal transduction (GO:0032012)3.65474561
25tolerance induction (GO:0002507)3.62868127
26detection of bacterium (GO:0016045)3.56604132
27positive regulation of CREB transcription factor activity (GO:0032793)3.54731868
28detection of other organism (GO:0098543)3.48412425
29positive regulation of Rap GTPase activity (GO:0032854)3.45749037
30regulation of B cell receptor signaling pathway (GO:0050855)3.41439809
31response to muramyl dipeptide (GO:0032495)3.40634218
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29982101
33negative regulation of leukocyte mediated immunity (GO:0002704)3.26024271
34signal complex assembly (GO:0007172)3.26010094
35response to interleukin-15 (GO:0070672)3.23026495
36regulation of ARF GTPase activity (GO:0032312)3.18882730
37positive regulation by symbiont of host defense response (GO:0052509)3.18376801
38modulation by symbiont of host defense response (GO:0052031)3.18376801
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18376801
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18376801
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.18376801
42modulation by symbiont of host immune response (GO:0052553)3.18376801
43histone H3-K36 demethylation (GO:0070544)2.99772431
44regulation of Rap GTPase activity (GO:0032317)2.99078486
45macrophage activation involved in immune response (GO:0002281)2.90188868
46antigen processing and presentation via MHC class Ib (GO:0002475)2.90144711
47positive regulation of granulocyte differentiation (GO:0030854)2.89194086
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86712247
49B cell receptor signaling pathway (GO:0050853)2.80768072
50histone H3-K4 trimethylation (GO:0080182)2.78575584
51regulation of T cell tolerance induction (GO:0002664)2.70034463
52negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65783730
53cellular extravasation (GO:0045123)2.65077483
54T cell migration (GO:0072678)2.64911044
55germinal center formation (GO:0002467)2.63964289
56detection of external biotic stimulus (GO:0098581)2.62387638
57cellular response to interleukin-15 (GO:0071350)2.61013325
58regulation of beta-amyloid formation (GO:1902003)2.57678740
59regulation of tolerance induction (GO:0002643)2.55652036
60regulation of regulatory T cell differentiation (GO:0045589)2.53252292
61negative regulation of innate immune response (GO:0045824)2.52281642
62positive regulation of tolerance induction (GO:0002645)2.51149201
63regulation of B cell differentiation (GO:0045577)2.47237608
64cerebellar Purkinje cell differentiation (GO:0021702)2.47168283
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45715107
66negative regulation of immunoglobulin mediated immune response (GO:0002890)2.43959245
67negative regulation of B cell mediated immunity (GO:0002713)2.43959245
68negative regulation of adaptive immune response (GO:0002820)2.42577987
69regulation of granulocyte differentiation (GO:0030852)2.40642617
70antigen receptor-mediated signaling pathway (GO:0050851)2.40046610
71positive regulation of cellular amide metabolic process (GO:0034250)2.39728320
72histone H3-K9 modification (GO:0061647)2.38919329
73negative regulation of interleukin-6 production (GO:0032715)2.38030216
74natural killer cell differentiation (GO:0001779)2.37917746
75detection of biotic stimulus (GO:0009595)2.37261562
76Peyers patch development (GO:0048541)2.36985699
77mucosal-associated lymphoid tissue development (GO:0048537)2.36985699
78regulation of alpha-beta T cell proliferation (GO:0046640)2.36863306
79T cell receptor signaling pathway (GO:0050852)2.35658956
80positive regulation of histone deacetylation (GO:0031065)2.35638310
81negative regulation of glycoprotein biosynthetic process (GO:0010561)2.35398906
82regulation of natural killer cell mediated immunity (GO:0002715)2.33432876
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.33432876
84positive regulation of B cell differentiation (GO:0045579)2.31568409
85negative regulation of myotube differentiation (GO:0010832)2.30841266
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.30839011
87negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.30240604
88regulation of T cell mediated cytotoxicity (GO:0001914)2.29798065
89negative regulation of interleukin-12 production (GO:0032695)2.29625804
90regulation of interleukin-2 biosynthetic process (GO:0045076)2.28638733
91mast cell activation (GO:0045576)2.28353906
92histone lysine demethylation (GO:0070076)2.27571445
93negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26936316
94peptidyl-tyrosine autophosphorylation (GO:0038083)2.24536517
95regulation of histone H3-K27 methylation (GO:0061085)2.24176911
96T cell homeostasis (GO:0043029)2.23980589
97regulation of amyloid precursor protein catabolic process (GO:1902991)2.22561348
98regulation of interferon-beta biosynthetic process (GO:0045357)2.22371296
99regulation of cellular amide metabolic process (GO:0034248)2.21771956
100negative regulation of type 2 immune response (GO:0002829)2.20415234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.55928345
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.17250925
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.80128971
4DROSHA_22980978_ChIP-Seq_HELA_Human2.77935997
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.68939280
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.65110657
7KDM2B_26808549_Chip-Seq_DND41_Human2.40583055
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37591149
9VDR_21846776_ChIP-Seq_THP-1_Human2.36583080
10RUNX_20019798_ChIP-Seq_JUKART_Human2.31841102
11TCF7_22412390_ChIP-Seq_EML_Mouse2.30980565
12MYC_22102868_ChIP-Seq_BL_Human2.18715881
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18656989
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14695928
15LXR_22292898_ChIP-Seq_THP-1_Human2.05679710
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04280110
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97532954
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97207218
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94463749
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93900155
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92241707
22MAF_26560356_Chip-Seq_TH1_Human1.89608445
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.82260867
24GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80248697
25UTX_26944678_Chip-Seq_JUKART_Human1.79964422
26MAF_26560356_Chip-Seq_TH2_Human1.76626924
27KDM2B_26808549_Chip-Seq_K562_Human1.76130999
28VDR_24763502_ChIP-Seq_THP-1_Human1.70775056
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67421169
30SCL_19346495_ChIP-Seq_HPC-7_Human1.63992478
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61017732
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58474344
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57568918
34SPI1_23127762_ChIP-Seq_K562_Human1.55066294
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.54205413
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54149716
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.53846154
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52287112
39SMC4_20622854_ChIP-Seq_HELA_Human1.51613297
40P68_20966046_ChIP-Seq_HELA_Human1.49855840
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48153374
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48108324
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.44256766
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39919557
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.34752606
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33800805
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.31720810
48GATA1_19941826_ChIP-Seq_K562_Human1.31660075
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31172898
50MYB_26560356_Chip-Seq_TH2_Human1.30476886
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.28279609
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25661213
53MYB_26560356_Chip-Seq_TH1_Human1.24673057
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24454781
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.24286176
56EZH2_22144423_ChIP-Seq_EOC_Human1.24097278
57BCOR_27268052_Chip-Seq_Bcells_Human1.23933036
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23700252
59OCT4_19829295_ChIP-Seq_ESCs_Human1.23296653
60BCL6_27268052_Chip-Seq_Bcells_Human1.21478223
61* CTCF_27219007_Chip-Seq_Bcells_Human1.18984550
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17386284
63GATA3_27048872_Chip-Seq_THYMUS_Human1.17175607
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.16752741
65* TP63_22573176_ChIP-Seq_HFKS_Human1.15837098
66CREB1_26743006_Chip-Seq_LNCaP_Human1.14791764
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11824421
68NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11797767
69* RACK7_27058665_Chip-Seq_MCF-7_Human1.10818833
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10689543
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.10628587
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10467237
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09798266
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.09546886
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08919379
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08444544
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08430667
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.07180718
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03639069
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02365439
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01527101
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.00265500
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96705601
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.95933317
85PHF8_20622854_ChIP-Seq_HELA_Human0.95773788
86BP1_19119308_ChIP-ChIP_Hs578T_Human0.94422261
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94266881
88STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94079146
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94012917
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92938432
91VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92694526
92E2F1_20622854_ChIP-Seq_HELA_Human0.91896807
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91833546
94SA1_27219007_Chip-Seq_Bcells_Human0.90812532
95REST_21632747_ChIP-Seq_MESCs_Mouse0.90601439
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89951143
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87678902
98KLF4_19829295_ChIP-Seq_ESCs_Human0.86808200
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86000316
100RNF2_27304074_Chip-Seq_ESCs_Mouse0.85565929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.73544936
2MP0003763_abnormal_thymus_physiology3.46395723
3MP0003724_increased_susceptibility_to3.19810712
4MP0004381_abnormal_hair_follicle2.75540407
5MP0003303_peritoneal_inflammation2.69637258
6MP0001800_abnormal_humoral_immune2.61771374
7MP0005671_abnormal_response_to2.48050091
8MP0004859_abnormal_synaptic_plasticity2.45746836
9MP0000685_abnormal_immune_system2.36301486
10MP0003172_abnormal_lysosome_physiology2.31710280
11MP0001501_abnormal_sleep_pattern2.29371015
12MP0005387_immune_system_phenotype2.22803164
13MP0001790_abnormal_immune_system2.22803164
14MP0005000_abnormal_immune_tolerance2.19244339
15MP0004947_skin_inflammation2.16335722
16MP0001835_abnormal_antigen_presentation2.04992826
17MP0002723_abnormal_immune_serum2.03797246
18MP0002420_abnormal_adaptive_immunity2.00644525
19MP0005025_abnormal_response_to1.99126504
20MP0001819_abnormal_immune_cell1.99023501
21MP0002419_abnormal_innate_immunity1.97216469
22MP0002452_abnormal_antigen_presenting1.81491351
23MP0009278_abnormal_bone_marrow1.78160313
24MP0003300_gastrointestinal_ulcer1.69782419
25MP0004130_abnormal_muscle_cell1.68941929
26MP0001873_stomach_inflammation1.66781149
27MP0002933_joint_inflammation1.66125048
28MP0003866_abnormal_defecation1.64260643
29MP0002009_preneoplasia1.63747376
30MP0003690_abnormal_glial_cell1.62351268
31MP0002653_abnormal_ependyma_morphology1.58444004
32MP0001986_abnormal_taste_sensitivity1.56410680
33MP0000716_abnormal_immune_system1.56352427
34MP0001851_eye_inflammation1.56080840
35MP0002405_respiratory_system_inflammati1.55427119
36MP0001533_abnormal_skeleton_physiology1.55414450
37MP0000703_abnormal_thymus_morphology1.52758936
38MP0002398_abnormal_bone_marrow1.52482200
39MP0003635_abnormal_synaptic_transmissio1.51861651
40MP0001348_abnormal_lacrimal_gland1.46487154
41MP0008569_lethality_at_weaning1.37689399
42MP0005076_abnormal_cell_differentiation1.36104574
43MP0002063_abnormal_learning/memory/cond1.35792359
44MP0010155_abnormal_intestine_physiology1.35750617
45MP0003329_amyloid_beta_deposits1.31758828
46MP0002064_seizures1.31497866
47MP0003045_fibrosis1.31305907
48MP0009333_abnormal_splenocyte_physiolog1.27402630
49MP0009785_altered_susceptibility_to1.25511267
50MP0008260_abnormal_autophagy1.23727085
51MP0005377_hearing/vestibular/ear_phenot1.23692715
52MP0003878_abnormal_ear_physiology1.23692715
53MP0003191_abnormal_cellular_cholesterol1.20526833
54MP0005423_abnormal_somatic_nervous1.19867115
55MP0002396_abnormal_hematopoietic_system1.18849351
56MP0002722_abnormal_immune_system1.17141343
57MP0004510_myositis1.15762592
58MP0003879_abnormal_hair_cell1.14245882
59MP0000689_abnormal_spleen_morphology1.13668727
60MP0006082_CNS_inflammation1.07892700
61MP0002429_abnormal_blood_cell1.05889634
62MP0003828_pulmonary_edema1.05849762
63MP0001502_abnormal_circadian_rhythm1.04492630
64MP0001486_abnormal_startle_reflex1.02995252
65MP0001845_abnormal_inflammatory_respons1.00001330
66MP0005167_abnormal_blood-brain_barrier0.99156833
67MP0005310_abnormal_salivary_gland0.95440802
68MP0008961_abnormal_basal_metabolism0.95221265
69MP0005535_abnormal_body_temperature0.94494770
70MP0002572_abnormal_emotion/affect_behav0.91833488
71MP0009745_abnormal_behavioral_response0.91254651
72MP0002148_abnormal_hypersensitivity_rea0.88489651
73MP0002998_abnormal_bone_remodeling0.87969742
74MP0002822_catalepsy0.86249637
75MP0005075_abnormal_melanosome_morpholog0.85005267
76MP0004185_abnormal_adipocyte_glucose0.83742486
77MP0002796_impaired_skin_barrier0.81270205
78MP0002249_abnormal_larynx_morphology0.80524698
79MP0004883_abnormal_blood_vessel0.80214823
80MP0000604_amyloidosis0.79629862
81MP0005464_abnormal_platelet_physiology0.79297576
82MP0004043_abnormal_pH_regulation0.79141936
83MP0001663_abnormal_digestive_system0.78896812
84MP0008874_decreased_physiological_sensi0.76871496
85MP0003453_abnormal_keratinocyte_physiol0.75207431
86MP0001968_abnormal_touch/_nociception0.74849069
87MP0000465_gastrointestinal_hemorrhage0.73521013
88MP0005058_abnormal_lysosome_morphology0.73225928
89MP0003880_abnormal_central_pattern0.73139398
90MP0001765_abnormal_ion_homeostasis0.73064127
91MP0004885_abnormal_endolymph0.72991939
92MP0001849_ear_inflammation0.71814266
93MP0005666_abnormal_adipose_tissue0.70978377
94MP0003787_abnormal_imprinting0.70103955
95MP0001970_abnormal_pain_threshold0.68120598
96MP0002272_abnormal_nervous_system0.65858311
97MP0005388_respiratory_system_phenotype0.65822169
98MP0002133_abnormal_respiratory_system0.65822169
99MP0008469_abnormal_protein_level0.65695176
100MP0005409_darkened_coat_color0.64684399

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.21128714
2Increased IgE level (HP:0003212)4.42512595
3Obstructive sleep apnea (HP:0002870)4.21538168
4Myositis (HP:0100614)4.13994792
5Pustule (HP:0200039)3.91359556
6Papilledema (HP:0001085)3.62910973
7Optic neuritis (HP:0100653)3.60478131
8Retrobulbar optic neuritis (HP:0100654)3.60478131
9Orchitis (HP:0100796)3.47753892
10Recurrent fungal infections (HP:0002841)3.44474550
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.43937299
12Recurrent bacterial skin infections (HP:0005406)3.39349121
13Abnormality of the fingertips (HP:0001211)3.31333821
14Panhypogammaglobulinemia (HP:0003139)3.25958185
15Stomatitis (HP:0010280)3.04066962
16Recurrent abscess formation (HP:0002722)3.04034963
17Elevated erythrocyte sedimentation rate (HP:0003565)2.97890505
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.97002804
19Diplopia (HP:0000651)2.93612638
20Abnormality of binocular vision (HP:0011514)2.93612638
21Colitis (HP:0002583)2.91748873
22Encephalitis (HP:0002383)2.82486685
23Recurrent cutaneous fungal infections (HP:0011370)2.81504880
24Chronic mucocutaneous candidiasis (HP:0002728)2.81504880
25Global brain atrophy (HP:0002283)2.77621388
26Gastrointestinal infarctions (HP:0005244)2.73018288
27Keratoconjunctivitis sicca (HP:0001097)2.70603059
28Supranuclear gaze palsy (HP:0000605)2.66778462
29Meningitis (HP:0001287)2.63994240
30Recurrent gram-negative bacterial infections (HP:0005420)2.63288372
31Abnormality of macrophages (HP:0004311)2.62402319
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61905659
33Keratoconjunctivitis (HP:0001096)2.59547712
34Hemiplegia (HP:0002301)2.58240639
35Spontaneous hematomas (HP:0007420)2.58143067
36Prolonged bleeding time (HP:0003010)2.57362212
37Gastrointestinal inflammation (HP:0004386)2.55755321
38Recurrent skin infections (HP:0001581)2.54276194
39Inflammation of the large intestine (HP:0002037)2.53731639
40Annular pancreas (HP:0001734)2.40889731
41Hemoptysis (HP:0002105)2.36506068
42Mediastinal lymphadenopathy (HP:0100721)2.33128374
43T lymphocytopenia (HP:0005403)2.32220619
44Broad face (HP:0000283)2.30776208
45Hypochromic anemia (HP:0001931)2.30685379
46Onion bulb formation (HP:0003383)2.29871888
47Gingivitis (HP:0000230)2.24211440
48Genetic anticipation (HP:0003743)2.22303587
49Vasculitis (HP:0002633)2.17488539
50Ankle clonus (HP:0011448)2.16028654
51Clumsiness (HP:0002312)2.09675809
52Abnormality of T cell number (HP:0011839)2.07463942
53Verrucae (HP:0200043)2.06876000
54Papilloma (HP:0012740)2.06876000
55Obstructive lung disease (HP:0006536)2.04905450
56Chronic obstructive pulmonary disease (HP:0006510)2.04905450
57Segmental peripheral demyelination/remyelination (HP:0003481)2.03971257
58Neurofibrillary tangles (HP:0002185)2.00782691
59Neuronal loss in central nervous system (HP:0002529)1.99198644
60Progressive cerebellar ataxia (HP:0002073)1.98855307
61Recurrent viral infections (HP:0004429)1.96820127
62Bronchomalacia (HP:0002780)1.94122566
63Cellulitis (HP:0100658)1.92388035
64Stereotypic behavior (HP:0000733)1.91822146
65Pulmonary embolism (HP:0002204)1.91190851
66Agammaglobulinemia (HP:0004432)1.90773310
67Chest pain (HP:0100749)1.87656923
68Pulmonary infiltrates (HP:0002113)1.86189167
69Spinal canal stenosis (HP:0003416)1.85381383
70Sleep apnea (HP:0010535)1.81976162
71Metaphyseal cupping (HP:0003021)1.81484508
72Increased cerebral lipofuscin (HP:0011813)1.81054999
73Slow saccadic eye movements (HP:0000514)1.80870552
74Postural instability (HP:0002172)1.80863027
75Supernumerary bones of the axial skeleton (HP:0009144)1.80207834
76Cerebral aneurysm (HP:0004944)1.79059288
77Abnormality of T cells (HP:0002843)1.79038027
78Malnutrition (HP:0004395)1.76288752
79Abnormality of the endocardium (HP:0004306)1.75325307
80Hypochromic microcytic anemia (HP:0004840)1.75310881
81Seborrheic dermatitis (HP:0001051)1.75151610
82Leukocytosis (HP:0001974)1.74944069
83Granulocytopenia (HP:0001913)1.74143773
84Interstitial pulmonary disease (HP:0006530)1.74040353
85Stomach cancer (HP:0012126)1.72525926
86Gangrene (HP:0100758)1.71384448
87Febrile seizures (HP:0002373)1.71286031
88Epileptic encephalopathy (HP:0200134)1.70897824
89Rapidly progressive (HP:0003678)1.70810032
90Impaired smooth pursuit (HP:0007772)1.70303650
91Supernumerary ribs (HP:0005815)1.70075285
92Abnormality of nail color (HP:0100643)1.68388177
93Acne (HP:0001061)1.64068332
94Vertigo (HP:0002321)1.63184346
95EMG: neuropathic changes (HP:0003445)1.62991190
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.62899556
97Neoplasm of the heart (HP:0100544)1.62857828
98Cheilitis (HP:0100825)1.62607572
99Polygenic inheritance (HP:0010982)1.62018943
100Epistaxis (HP:0000421)1.61861086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.14677399
2TRIB32.85144526
3RIPK42.70328689
4SIK22.67008185
5PRPF4B2.63833570
6TNK22.39728960
7MAP3K132.00299261
8CAMKK11.97075605
9MARK21.92143289
10TYK21.85603146
11FES1.76345899
12SIK11.74251596
13MAP3K71.72971995
14TYRO31.63488633
15GRK61.61132578
16FGFR41.61020563
17ZAP701.58000928
18BLK1.52701914
19MAP2K31.43956810
20ERN11.43491934
21BTK1.41504995
22DAPK21.39512298
23EEF2K1.38288937
24ITK1.36747320
25CDC42BPA1.35338423
26NTRK21.34775748
27EPHB11.34187100
28SIK31.33602429
29CSK1.32328937
30TXK1.30587103
31MAPK121.27540965
32RIPK11.21936370
33FGFR31.21235284
34FGFR21.19294971
35JAK11.19286720
36SYK1.18464240
37CDK121.18223446
38HCK1.15875582
39PRKD21.12584096
40IRAK41.12494719
41NTRK31.12286687
42MAP2K61.11775535
43MAPK151.11004744
44TAOK31.09893814
45CAMKK21.04733541
46ICK1.04252415
47JAK31.03039094
48CAMK1D1.02742831
49UHMK10.98231518
50IKBKE0.97444774
51LCK0.96840155
52HIPK20.88933186
53SMG10.86552937
54PTK60.86113572
55STK110.86022956
56MAP3K140.85854842
57PRKCH0.85522255
58TAOK10.83747741
59CAMK40.83180519
60PDK10.82721520
61MAPK70.82279110
62JAK20.79939791
63FGR0.79821297
64MAP3K60.78944510
65RET0.76124970
66SGK2230.75167365
67SGK4940.75167365
68STK380.74069259
69WNK10.73622222
70EPHA30.72767291
71TBK10.70192576
72PDPK10.70030264
73CAMK10.69213168
74SGK30.68109099
75MAP3K10.67819477
76LYN0.66620494
77CSF1R0.66274273
78NLK0.65952101
79PKN20.65873177
80SGK20.65570286
81KSR20.65030331
82DYRK1B0.62851923
83RPS6KA20.60622491
84RPS6KA60.60479826
85MAP3K100.57743374
86MAP3K30.57221341
87FYN0.57101295
88RPS6KC10.56670276
89RPS6KL10.56670276
90MAPK130.55887801
91MARK30.55862466
92MAP3K110.54187614
93BMX0.53481289
94PDGFRB0.51207150
95EPHA40.51155213
96ERBB20.49220635
97DYRK1A0.49088112
98PAK60.48986805
99PASK0.48257704
100MAP2K20.48054390

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046601.87526068
2Osteoclast differentiation_Homo sapiens_hsa043801.83832469
3Primary immunodeficiency_Homo sapiens_hsa053401.74252029
4B cell receptor signaling pathway_Homo sapiens_hsa046621.70606705
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.61348355
6* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57436055
7Acute myeloid leukemia_Homo sapiens_hsa052211.57146502
8Phosphatidylinositol signaling system_Homo sapiens_hsa040701.55013307
9Notch signaling pathway_Homo sapiens_hsa043301.54845372
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49174640
11* VEGF signaling pathway_Homo sapiens_hsa043701.44250788
12Other glycan degradation_Homo sapiens_hsa005111.35505853
13Long-term potentiation_Homo sapiens_hsa047201.32819576
14Leishmaniasis_Homo sapiens_hsa051401.32388511
15* Phospholipase D signaling pathway_Homo sapiens_hsa040721.25720001
16* GnRH signaling pathway_Homo sapiens_hsa049121.24075148
17* Choline metabolism in cancer_Homo sapiens_hsa052311.23814713
18Staphylococcus aureus infection_Homo sapiens_hsa051501.22520483
19Inositol phosphate metabolism_Homo sapiens_hsa005621.20676483
20Chemokine signaling pathway_Homo sapiens_hsa040621.19234447
21Nicotine addiction_Homo sapiens_hsa050331.18842216
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17072845
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16908874
24* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15031687
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13833334
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13323700
27Non-small cell lung cancer_Homo sapiens_hsa052231.11571945
28Graft-versus-host disease_Homo sapiens_hsa053321.11073031
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.10665316
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.09680206
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09025758
32Tuberculosis_Homo sapiens_hsa051521.07544886
33Gastric acid secretion_Homo sapiens_hsa049711.07045998
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.06049835
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05286055
36Cholinergic synapse_Homo sapiens_hsa047251.04344450
37Circadian entrainment_Homo sapiens_hsa047131.04047225
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03284481
39Allograft rejection_Homo sapiens_hsa053301.00781627
40ABC transporters_Homo sapiens_hsa020101.00507557
41* Platelet activation_Homo sapiens_hsa046111.00379662
42* Glycerophospholipid metabolism_Homo sapiens_hsa005641.00090076
43Morphine addiction_Homo sapiens_hsa050320.99180066
44Dorso-ventral axis formation_Homo sapiens_hsa043200.98998685
45Autoimmune thyroid disease_Homo sapiens_hsa053200.98926725
46mTOR signaling pathway_Homo sapiens_hsa041500.98230626
47TNF signaling pathway_Homo sapiens_hsa046680.97695534
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97649403
49Measles_Homo sapiens_hsa051620.95801021
50Toxoplasmosis_Homo sapiens_hsa051450.95753440
51Type II diabetes mellitus_Homo sapiens_hsa049300.94354701
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94071775
53Amphetamine addiction_Homo sapiens_hsa050310.93536863
54* Glutamatergic synapse_Homo sapiens_hsa047240.93029557
55* MAPK signaling pathway_Homo sapiens_hsa040100.90926144
56Prolactin signaling pathway_Homo sapiens_hsa049170.86734602
57Estrogen signaling pathway_Homo sapiens_hsa049150.85403916
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85321142
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.83919973
60* Oxytocin signaling pathway_Homo sapiens_hsa049210.83191148
61Renal cell carcinoma_Homo sapiens_hsa052110.83142618
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83115624
63* Vascular smooth muscle contraction_Homo sapiens_hsa042700.82898602
64* alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82472405
65ErbB signaling pathway_Homo sapiens_hsa040120.81771429
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79065420
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78684455
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78272447
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.77414296
70FoxO signaling pathway_Homo sapiens_hsa040680.75817701
71Cocaine addiction_Homo sapiens_hsa050300.75690718
72Hepatitis C_Homo sapiens_hsa051600.75680182
73Hematopoietic cell lineage_Homo sapiens_hsa046400.75031874
74cAMP signaling pathway_Homo sapiens_hsa040240.74655340
75Influenza A_Homo sapiens_hsa051640.74486685
76Calcium signaling pathway_Homo sapiens_hsa040200.74413524
77Salivary secretion_Homo sapiens_hsa049700.74102268
78Chronic myeloid leukemia_Homo sapiens_hsa052200.73842810
79* Ras signaling pathway_Homo sapiens_hsa040140.73791905
80Rap1 signaling pathway_Homo sapiens_hsa040150.73612488
81GABAergic synapse_Homo sapiens_hsa047270.73071304
82Insulin resistance_Homo sapiens_hsa049310.72683303
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72249908
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72171645
85Endometrial cancer_Homo sapiens_hsa052130.71332666
86Insulin secretion_Homo sapiens_hsa049110.70526578
87Synaptic vesicle cycle_Homo sapiens_hsa047210.70116452
88Renin secretion_Homo sapiens_hsa049240.69569405
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.69370525
90Endocytosis_Homo sapiens_hsa041440.69291042
91Type I diabetes mellitus_Homo sapiens_hsa049400.68188652
92Hepatitis B_Homo sapiens_hsa051610.68009651
93* Linoleic acid metabolism_Homo sapiens_hsa005910.64930635
94Malaria_Homo sapiens_hsa051440.64354938
95Colorectal cancer_Homo sapiens_hsa052100.63872541
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.63593429
97Pancreatic cancer_Homo sapiens_hsa052120.62925981
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62097186
99Dopaminergic synapse_Homo sapiens_hsa047280.61601784
100Insulin signaling pathway_Homo sapiens_hsa049100.60378877

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