JMJD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.33602001
2adenosine receptor signaling pathway (GO:0001973)5.72305063
3cellular response to ATP (GO:0071318)5.17041198
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.07920002
5L-phenylalanine metabolic process (GO:0006558)5.07920002
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.07707394
7L-phenylalanine catabolic process (GO:0006559)5.07707394
8DNA strand renaturation (GO:0000733)5.00114370
9UV protection (GO:0009650)4.98254342
10negative regulation of cell aging (GO:0090344)4.80801315
11negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.80735748
12proline biosynthetic process (GO:0006561)4.66913462
13mannose metabolic process (GO:0006013)4.64367730
14peptidyl-glutamic acid carboxylation (GO:0017187)4.53871239
15protein carboxylation (GO:0018214)4.53871239
16protein retention in ER lumen (GO:0006621)4.45414810
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.36455392
18protoporphyrinogen IX biosynthetic process (GO:0006782)4.30592696
19rRNA methylation (GO:0031167)4.24718122
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24359501
21positive regulation of protein kinase C signaling (GO:0090037)4.17407229
22regulation of skeletal muscle contraction (GO:0014819)4.13830422
23rRNA modification (GO:0000154)3.99295216
24adenine nucleotide transport (GO:0051503)3.98729784
25protein insertion into membrane (GO:0051205)3.96492090
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93802830
27protoporphyrinogen IX metabolic process (GO:0046501)3.93534319
28ATP synthesis coupled proton transport (GO:0015986)3.93243720
29energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93243720
30folic acid metabolic process (GO:0046655)3.90838499
31cellular ketone body metabolic process (GO:0046950)3.88428412
32aromatic amino acid family catabolic process (GO:0009074)3.83710104
33semaphorin-plexin signaling pathway (GO:0071526)3.73782552
34tooth mineralization (GO:0034505)3.71592721
35cotranslational protein targeting to membrane (GO:0006613)3.70466037
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69412794
37respiratory electron transport chain (GO:0022904)3.68142523
38planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64720590
39protein targeting to ER (GO:0045047)3.64266954
40viral transcription (GO:0019083)3.63731108
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.61443886
42electron transport chain (GO:0022900)3.61384025
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.60427121
44G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.55978420
45regulation of cytokine production involved in inflammatory response (GO:1900015)3.55186579
46chaperone-mediated protein transport (GO:0072321)3.53373572
47protein localization to endoplasmic reticulum (GO:0070972)3.51676109
48lens fiber cell differentiation (GO:0070306)3.49533525
49regulation of translational fidelity (GO:0006450)3.47648065
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47628851
51purine ribonucleotide transport (GO:0015868)3.46536690
52translational termination (GO:0006415)3.45816081
53negative regulation of DNA-templated transcription, elongation (GO:0032785)3.36469361
54negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.36469361
55glyoxylate metabolic process (GO:0046487)3.34940142
56ketone body metabolic process (GO:1902224)3.34016043
57atrioventricular valve morphogenesis (GO:0003181)3.28872956
58heme biosynthetic process (GO:0006783)3.26646468
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23493060
60meiotic chromosome segregation (GO:0045132)3.21106557
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19204351
62respiratory chain complex IV assembly (GO:0008535)3.17980977
63pyrimidine nucleobase catabolic process (GO:0006208)3.17097066
64DNA replication checkpoint (GO:0000076)3.16870757
65aldehyde catabolic process (GO:0046185)3.15768618
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.15406412
67purine nucleotide transport (GO:0015865)3.14358596
68protein complex biogenesis (GO:0070271)3.14012219
69branched-chain amino acid catabolic process (GO:0009083)3.13249132
70apoptotic process involved in morphogenesis (GO:0060561)3.11868042
71proline metabolic process (GO:0006560)3.11603578
72ribosomal small subunit biogenesis (GO:0042274)3.09854543
73nucleotide-sugar biosynthetic process (GO:0009226)3.07934265
74regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07152818
75mitotic cell cycle arrest (GO:0071850)3.07064419
76fatty acid elongation (GO:0030497)3.04843097
77regulation of synapse structural plasticity (GO:0051823)3.03428914
78basement membrane organization (GO:0071711)3.03192241
79aromatic amino acid family metabolic process (GO:0009072)3.00990889
80protein import into peroxisome matrix (GO:0016558)2.99640744
81response to misfolded protein (GO:0051788)2.99027159
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96069630
83sensory perception of taste (GO:0050909)2.95916616
84regulation of fatty acid beta-oxidation (GO:0031998)2.94149629
85coenzyme A metabolic process (GO:0015936)2.92871381
86regulation of cell aging (GO:0090342)2.91522641
87endocytic recycling (GO:0032456)2.91005154
88peptidyl-arginine omega-N-methylation (GO:0035247)2.90561348
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.88190671
90NADH dehydrogenase complex assembly (GO:0010257)2.88190671
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88190671
92tRNA modification (GO:0006400)2.87119063
93sulfur amino acid catabolic process (GO:0000098)2.87108981
94bile acid biosynthetic process (GO:0006699)2.86254977
95negative regulation of erythrocyte differentiation (GO:0045647)2.85538807
96short-chain fatty acid metabolic process (GO:0046459)2.85097252
97regulation of oxidative phosphorylation (GO:0002082)2.84239535
98granulocyte differentiation (GO:0030851)2.83731580
99mitochondrial respiratory chain complex assembly (GO:0033108)2.83008932
100cysteine metabolic process (GO:0006534)2.82989641
101purinergic nucleotide receptor signaling pathway (GO:0035590)2.82798662
102amyloid precursor protein catabolic process (GO:0042987)2.81685689
103heme metabolic process (GO:0042168)2.81075371
104nucleoside transmembrane transport (GO:1901642)2.80528882
105rRNA transcription (GO:0009303)2.80081847
106ethanol oxidation (GO:0006069)2.79967375
107DNA deamination (GO:0045006)2.79936768
108branched-chain amino acid metabolic process (GO:0009081)2.79309537
109negative regulation of cell size (GO:0045792)2.78625194
110modulation by virus of host process (GO:0019054)2.78574010
111G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.78355985
112indole-containing compound catabolic process (GO:0042436)2.77797611
113indolalkylamine catabolic process (GO:0046218)2.77797611
114tryptophan catabolic process (GO:0006569)2.77797611
115sphingomyelin metabolic process (GO:0006684)2.77559727
116regulation of apoptotic process involved in morphogenesis (GO:1902337)2.76009510
117regulation of hydrogen peroxide metabolic process (GO:0010310)2.75915848
118base-excision repair, AP site formation (GO:0006285)2.75385721
119exocrine pancreas development (GO:0031017)2.74729132
120GMP metabolic process (GO:0046037)2.74643517
121positive regulation of cellular amine metabolic process (GO:0033240)2.73328475
122response to ATP (GO:0033198)2.73319146
123nucleotide salvage (GO:0043173)2.73148003
124coenzyme A biosynthetic process (GO:0015937)2.72301561
125tryptophan metabolic process (GO:0006568)2.71789426
126translational elongation (GO:0006414)2.71540624
127negative regulation of response to food (GO:0032096)2.71156334
128negative regulation of appetite (GO:0032099)2.71156334
129viral life cycle (GO:0019058)2.70999035
130coenzyme catabolic process (GO:0009109)2.70567347
131misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.70256468
132regulation of cholesterol biosynthetic process (GO:0045540)2.69998961
133type B pancreatic cell proliferation (GO:0044342)2.69530225
134regulation of chromatin binding (GO:0035561)2.68828761
135cellular protein complex disassembly (GO:0043624)2.67662806
136tyrosine metabolic process (GO:0006570)2.67451886
137endocrine pancreas development (GO:0031018)2.65842258
138intestinal cholesterol absorption (GO:0030299)2.65345287
139amine catabolic process (GO:0009310)2.65204099
140cellular biogenic amine catabolic process (GO:0042402)2.65204099
141cellular amino acid catabolic process (GO:0009063)2.65160025
142glutathione biosynthetic process (GO:0006750)2.63859706
143alpha-amino acid catabolic process (GO:1901606)2.63158095
144ribosomal small subunit assembly (GO:0000028)2.62112218
145short-term memory (GO:0007614)2.60488777
146motile cilium assembly (GO:0044458)2.60015455
147urinary tract smooth muscle contraction (GO:0014848)2.59915250
148peroxisome fission (GO:0016559)2.58607041
149forebrain neuron development (GO:0021884)2.58317489
150cellular response to virus (GO:0098586)2.58109340
151very long-chain fatty acid metabolic process (GO:0000038)2.57943177
152melanin biosynthetic process (GO:0042438)2.57416795
153pentose metabolic process (GO:0019321)2.56792053
154phosphatidylglycerol biosynthetic process (GO:0006655)2.56764720
155UTP biosynthetic process (GO:0006228)2.55799385
156pyrimidine nucleoside salvage (GO:0043097)2.54723780
157pyrimidine-containing compound salvage (GO:0008655)2.54723780
158purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.54678665
159ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.54678665
160nucleoside bisphosphate biosynthetic process (GO:0033866)2.54678665
161ribonucleoprotein complex biogenesis (GO:0022613)2.54371624
162homocysteine metabolic process (GO:0050667)2.53917490
163pyrimidine nucleotide catabolic process (GO:0006244)2.53858519
164cellular modified amino acid catabolic process (GO:0042219)2.53289776
165lysine catabolic process (GO:0006554)2.51188985
166lysine metabolic process (GO:0006553)2.51188985
167carboxylic acid catabolic process (GO:0046395)2.50178123
168organic acid catabolic process (GO:0016054)2.50178123
169fatty acid catabolic process (GO:0009062)2.50148491
170purinergic receptor signaling pathway (GO:0035587)2.49345312
171monocarboxylic acid catabolic process (GO:0072329)2.47988183
172modulation by symbiont of host cellular process (GO:0044068)2.47617481
173regulation of cholesterol metabolic process (GO:0090181)2.47309675
174maturation of SSU-rRNA (GO:0030490)2.45972823
175mannosylation (GO:0097502)2.45172331
176kynurenine metabolic process (GO:0070189)2.45023722
177triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43986144
178regulation of glucocorticoid metabolic process (GO:0031943)2.43594974
179bile acid metabolic process (GO:0008206)2.43242057
180arginine metabolic process (GO:0006525)2.42139797
181aspartate family amino acid catabolic process (GO:0009068)2.42079501
182fucosylation (GO:0036065)2.41396377
183pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.41130177
184protein maturation by protein folding (GO:0022417)2.40150317
185deoxyribonucleotide catabolic process (GO:0009264)2.39963894
186heterochromatin organization (GO:0070828)2.39640603
187focal adhesion assembly (GO:0048041)2.39137464
188cell-substrate adherens junction assembly (GO:0007045)2.39137464
189nucleoside transport (GO:0015858)2.37863903
190GDP-mannose metabolic process (GO:0019673)2.37818478
191mitotic G1 DNA damage checkpoint (GO:0031571)2.37642390
192N-glycan processing (GO:0006491)2.37110089
193cytochrome complex assembly (GO:0017004)2.35760899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.17474405
2* VDR_21846776_ChIP-Seq_THP-1_Human3.46306813
3EZH2_22144423_ChIP-Seq_EOC_Human3.35601131
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34661843
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.91964629
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91174125
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83825668
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65116460
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58752637
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58511080
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47657247
12P68_20966046_ChIP-Seq_HELA_Human2.39748577
13RACK7_27058665_Chip-Seq_MCF-7_Human2.37731694
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.37469641
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33396558
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30855716
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30460367
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24698570
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21541433
20EGR1_23403033_ChIP-Seq_LIVER_Mouse2.20544121
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19528313
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17359351
23* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.15223274
24* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.15095473
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12370913
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.10376091
27MYC_22102868_ChIP-Seq_BL_Human2.07771617
28ELK3_25401928_ChIP-Seq_HUVEC_Human2.07731998
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99786910
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99605977
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97386596
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89687435
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.88979868
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.88257855
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.82231637
36MAF_26560356_Chip-Seq_TH2_Human1.81805906
37KDM2B_26808549_Chip-Seq_DND41_Human1.79374875
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79321739
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78196200
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78041203
41* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.77535624
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.77241801
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76893869
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.73990016
45BCL6_27268052_Chip-Seq_Bcells_Human1.72227718
46BCOR_27268052_Chip-Seq_Bcells_Human1.72197355
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.71266613
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.69625034
49SMC4_20622854_ChIP-Seq_HELA_Human1.67799682
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67191169
51ZNF263_19887448_ChIP-Seq_K562_Human1.66981216
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.66970616
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.64650064
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63348655
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60532714
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59730468
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58626058
58* ELF1_20517297_ChIP-Seq_JURKAT_Human1.58496908
59E2F1_20622854_ChIP-Seq_HELA_Human1.56825931
60VDR_24763502_ChIP-Seq_THP-1_Human1.55925821
61PHF8_20622854_ChIP-Seq_HELA_Human1.54318802
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.51982072
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51577106
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51505110
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50537360
66CREB1_26743006_Chip-Seq_LNCaP_Human1.49748144
67* FOXP1_21924763_ChIP-Seq_HESCs_Human1.48561806
68CTCF_21964334_Chip-Seq_Bcells_Human1.47042823
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46684743
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46684743
71RARA_24833708_ChIP-Seq_LIVER_Mouse1.46239384
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.46140871
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.45093171
74TCF7_22412390_ChIP-Seq_EML_Mouse1.44490796
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43842251
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43522534
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43414775
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43058072
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42818706
80MAF_26560356_Chip-Seq_TH1_Human1.42778327
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42589899
82KDM2B_26808549_Chip-Seq_K562_Human1.42416164
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42147532
84IGF1R_20145208_ChIP-Seq_DFB_Human1.41439597
85LXR_22292898_ChIP-Seq_THP-1_Human1.41285296
86RARB_24833708_ChIP-Seq_LIVER_Mouse1.41087451
87* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41043589
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.40235056
89* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39711415
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.39372115
91TP53_22127205_ChIP-Seq_IMR90_Human1.35815044
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34441449
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34184388
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.34146235
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.32662348
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32190034
97ATF3_27146783_Chip-Seq_COLON_Human1.29903314
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27761274
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.25885109
100CTCF_26484167_Chip-Seq_Bcells_Mouse1.23727105
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.23703713
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23453916
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22399257
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22162189
105* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21905853
106UTX_26944678_Chip-Seq_JUKART_Human1.21734547
107RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21585361
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20736346
109* XRN2_22483619_ChIP-Seq_HELA_Human1.20636330
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20006295
111* CTCF_27219007_Chip-Seq_Bcells_Human1.18500999
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18353288
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17897143
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17678593
115ETS1_21867929_ChIP-Seq_TH2_Mouse1.17345896
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16298516
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15250049
118NCOR1_26117541_ChIP-Seq_K562_Human1.14154712
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.13844878
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13804367
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12264602
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12085721
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12062606
124EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11757614
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11711522
126* CTCF_20526341_ChIP-Seq_ESCs_Human1.11692131
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11426311
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11406065
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11208024
130SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11071111
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10545137
132YY1_21170310_ChIP-Seq_MESCs_Mouse1.10512157
133TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09546491
134TP53_20018659_ChIP-ChIP_R1E_Mouse1.08834240
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08731542
136KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08476655
137* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08344943
138DCP1A_22483619_ChIP-Seq_HELA_Human1.07347880
139FOXM1_23109430_ChIP-Seq_U2OS_Human1.07336107
140ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07225383
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06472771
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03691106
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03248629
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03062153
145* TP63_22573176_ChIP-Seq_HFKS_Human1.03027852
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02234719
147E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02213435
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01021783
149SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00947284
150FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00089786
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00055632
152TAF15_26573619_Chip-Seq_HEK293_Human0.99579216
153HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99565820
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98758574
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.98654300
156GBX2_23144817_ChIP-Seq_PC3_Human0.98439101
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97955207
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.97584155
159HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96483756
160CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96426441
161* GABP_19822575_ChIP-Seq_HepG2_Human0.94230609
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94114587
163MYC_18555785_ChIP-Seq_MESCs_Mouse0.93871994
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93295932
165SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92864868
166MYC_18940864_ChIP-ChIP_HL60_Human0.92565022
167RING1B_27294783_Chip-Seq_ESCs_Mouse0.91884266
168REST_21632747_ChIP-Seq_MESCs_Mouse0.90084592
169SA1_27219007_Chip-Seq_Bcells_Human0.89727939
170* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85669952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.48978265
2MP0002139_abnormal_hepatobiliary_system4.38499479
3MP0003705_abnormal_hypodermis_morpholog3.94544105
4MP0005365_abnormal_bile_salt3.78718284
5MP0003011_delayed_dark_adaptation3.58027419
6MP0009379_abnormal_foot_pigmentation3.45140776
7MP0005360_urolithiasis3.40848636
8MP0005174_abnormal_tail_pigmentation3.26923103
9MP0005058_abnormal_lysosome_morphology3.26408259
10MP0005085_abnormal_gallbladder_physiolo3.12836987
11MP0003136_yellow_coat_color3.04642223
12MP0005423_abnormal_somatic_nervous2.71409904
13MP0005409_darkened_coat_color2.71031532
14MP0001188_hyperpigmentation2.66925972
15MP0005083_abnormal_biliary_tract2.64739960
16MP0006276_abnormal_autonomic_nervous2.62769170
17MP0003122_maternal_imprinting2.60151161
18MP0005220_abnormal_exocrine_pancreas2.59137070
19MP0008875_abnormal_xenobiotic_pharmacok2.58419698
20MP0003453_abnormal_keratinocyte_physiol2.50843076
21MP0010030_abnormal_orbit_morphology2.36139743
22MP0005645_abnormal_hypothalamus_physiol2.35899188
23MP0001661_extended_life_span2.32894421
24MP0001666_abnormal_nutrient_absorption2.30809040
25MP0000751_myopathy2.29988168
26MP0002638_abnormal_pupillary_reflex2.25986076
27MP0005501_abnormal_skin_physiology2.23786604
28MP0004185_abnormal_adipocyte_glucose2.16210941
29MP0005332_abnormal_amino_acid2.14350704
30MP0004858_abnormal_nervous_system2.10334902
31MP0005084_abnormal_gallbladder_morpholo2.07469606
32MP0003195_calcinosis2.07009694
33MP0005076_abnormal_cell_differentiation2.04175942
34MP0003880_abnormal_central_pattern2.01627386
35MP0002837_dystrophic_cardiac_calcinosis1.99242748
36MP0003111_abnormal_nucleus_morphology1.96094758
37MP0000003_abnormal_adipose_tissue1.90440911
38MP0001944_abnormal_pancreas_morphology1.84651264
39MP0004019_abnormal_vitamin_homeostasis1.80282892
40MP0000566_synostosis1.79836381
41MP0004043_abnormal_pH_regulation1.79655508
42MP0005330_cardiomyopathy1.79588952
43MP0002796_impaired_skin_barrier1.76000316
44MP0000750_abnormal_muscle_regeneration1.74730560
45MP0003252_abnormal_bile_duct1.70576753
46MP0005551_abnormal_eye_electrophysiolog1.70550632
47MP0001849_ear_inflammation1.62372633
48MP0001984_abnormal_olfaction1.58015119
49MP0005636_abnormal_mineral_homeostasis1.56258625
50MP0008995_early_reproductive_senescence1.53150165
51MP0004381_abnormal_hair_follicle1.52553254
52MP0010329_abnormal_lipoprotein_level1.51522398
53MP0003806_abnormal_nucleotide_metabolis1.50276695
54MP0006292_abnormal_olfactory_placode1.48674384
55MP0009840_abnormal_foam_cell1.45892222
56MP0005253_abnormal_eye_physiology1.44284105
57MP0003868_abnormal_feces_composition1.42652849
58MP0003693_abnormal_embryo_hatching1.41792206
59MP0002160_abnormal_reproductive_system1.40530766
60MP0005375_adipose_tissue_phenotype1.39730026
61MP0001958_emphysema1.38267812
62MP0005257_abnormal_intraocular_pressure1.37262660
63MP0000678_abnormal_parathyroid_gland1.35647281
64MP0006036_abnormal_mitochondrial_physio1.35157162
65MP0009643_abnormal_urine_homeostasis1.34400111
66MP0001873_stomach_inflammation1.34189368
67MP0009278_abnormal_bone_marrow1.33435727
68MP0005379_endocrine/exocrine_gland_phen1.31900023
69MP0002254_reproductive_system_inflammat1.31476819
70MP0005666_abnormal_adipose_tissue1.31372151
71MP0002102_abnormal_ear_morphology1.30700308
72MP0001502_abnormal_circadian_rhythm1.29846857
73MP0001664_abnormal_digestion1.29386312
74MP0001348_abnormal_lacrimal_gland1.29166564
75MP0000778_abnormal_nervous_system1.28843125
76MP0000538_abnormal_urinary_bladder1.27449271
77MP0000631_abnormal_neuroendocrine_gland1.27379525
78MP0001764_abnormal_homeostasis1.27271678
79MP0003279_aneurysm1.26831290
80MP0002249_abnormal_larynx_morphology1.26445642
81MP0001765_abnormal_ion_homeostasis1.25317342
82MP0003303_peritoneal_inflammation1.24506804
83MP0004130_abnormal_muscle_cell1.19739565
84MP0002653_abnormal_ependyma_morphology1.19542833
85MP0003959_abnormal_lean_body1.18860472
86MP0002078_abnormal_glucose_homeostasis1.18744488
87MP0005646_abnormal_pituitary_gland1.18588227
88MP0001529_abnormal_vocalization1.17121214
89MP0000462_abnormal_digestive_system1.15527548
90MP0004233_abnormal_muscle_weight1.15119355
91MP0002909_abnormal_adrenal_gland1.13604558
92MP0002693_abnormal_pancreas_physiology1.13585371
93MP0009384_cardiac_valve_regurgitation1.13418174
94MP0002118_abnormal_lipid_homeostasis1.13337637
95MP0000015_abnormal_ear_pigmentation1.12376858
96MP0002751_abnormal_autonomic_nervous1.11354355
97MP0004957_abnormal_blastocyst_morpholog1.11290148
98MP0000747_muscle_weakness1.10736662
99MP0002876_abnormal_thyroid_physiology1.06757216
100MP0005584_abnormal_enzyme/coenzyme_acti1.06525322
101MP0005623_abnormal_meninges_morphology1.05761460
102MP0009931_abnormal_skin_appearance1.03374458
103MP0000230_abnormal_systemic_arterial1.03154878
104MP0008438_abnormal_cutaneous_collagen1.03078692
105MP0002557_abnormal_social/conspecific_i1.02674117
106MP0003315_abnormal_perineum_morphology1.01467378
107MP0000613_abnormal_salivary_gland1.01006409
108MP0010386_abnormal_urinary_bladder1.00019940
109MP0003077_abnormal_cell_cycle0.99419590
110MP0008789_abnormal_olfactory_epithelium0.98874200
111MP0006072_abnormal_retinal_apoptosis0.98291335
112MP0003953_abnormal_hormone_level0.96322183
113MP0003172_abnormal_lysosome_physiology0.95904511
114MP0002060_abnormal_skin_morphology0.95150797
115MP0005410_abnormal_fertilization0.94630212
116MP0000470_abnormal_stomach_morphology0.94279364
117MP0005023_abnormal_wound_healing0.93619485
118MP0001756_abnormal_urination0.93389010
119MP0008260_abnormal_autophagy0.92379427
120MP0010234_abnormal_vibrissa_follicle0.91803945
121MP0002877_abnormal_melanocyte_morpholog0.90700202
122MP0010771_integument_phenotype0.90523917
123MP0002733_abnormal_thermal_nociception0.89385057
124MP0002138_abnormal_hepatobiliary_system0.89039349
125MP0009333_abnormal_splenocyte_physiolog0.87997856
126MP0001986_abnormal_taste_sensitivity0.87401646
127MP0005319_abnormal_enzyme/_coenzyme0.83910071
128MP0002069_abnormal_eating/drinking_beha0.83546430
129MP0005535_abnormal_body_temperature0.82663996
130MP0005381_digestive/alimentary_phenotyp0.80884456
131MP0000049_abnormal_middle_ear0.80862129
132MP0001905_abnormal_dopamine_level0.79831166
133MP0004145_abnormal_muscle_electrophysio0.79650935
134MP0000681_abnormal_thyroid_gland0.79176765
135MP0003186_abnormal_redox_activity0.79002929
136MP0002234_abnormal_pharynx_morphology0.77973565
137MP0004142_abnormal_muscle_tone0.77969773
138MP0002064_seizures0.77958047
139MP0001324_abnormal_eye_pigmentation0.77609936
140MP0000490_abnormal_crypts_of0.77567192
141MP0000759_abnormal_skeletal_muscle0.77399678
142MP0002272_abnormal_nervous_system0.76811180
143MP0002928_abnormal_bile_duct0.76375380
144MP0005451_abnormal_body_composition0.75649137
145MP0004133_heterotaxia0.75274512
146MP0002752_abnormal_somatic_nervous0.75143430
147MP0000858_altered_metastatic_potential0.75037133
148MP0009642_abnormal_blood_homeostasis0.74783681
149MP0009053_abnormal_anal_canal0.74111115
150MP0003635_abnormal_synaptic_transmissio0.74019178
151MP0000609_abnormal_liver_physiology0.73938797
152MP0002184_abnormal_innervation0.73420852
153MP0001216_abnormal_epidermal_layer0.73231438
154MP0003137_abnormal_impulse_conducting0.72819150
155MP0003283_abnormal_digestive_organ0.72809181
156MP0001346_abnormal_lacrimal_gland0.72737286
157MP0003091_abnormal_cell_migration0.70439058
158MP0005195_abnormal_posterior_eye0.70358658
159MP0000358_abnormal_cell_content/0.70118377
160MP0003329_amyloid_beta_deposits0.69663936
161MP0000013_abnormal_adipose_tissue0.69541679
162MP0000367_abnormal_coat/_hair0.68941620
163MP0001968_abnormal_touch/_nociception0.68722867
164MP0002132_abnormal_respiratory_system0.68112061
165MP0003638_abnormal_response/metabolism_0.67498227
166MP0004087_abnormal_muscle_fiber0.67438570
167MP0002932_abnormal_joint_morphology0.67211163
168MP0000733_abnormal_muscle_development0.66829547
169MP0003448_altered_tumor_morphology0.66426414
170MP0001919_abnormal_reproductive_system0.66411219
171MP0003879_abnormal_hair_cell0.65976391
172MP0002067_abnormal_sensory_capabilities0.65958769
173MP0003878_abnormal_ear_physiology0.65274486
174MP0005377_hearing/vestibular/ear_phenot0.65274486
175MP0005503_abnormal_tendon_morphology0.64201734
176MP0002089_abnormal_postnatal_growth/wei0.63444306
177MP0009250_abnormal_appendicular_skeleto0.62796123

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.03402140
2Thin bony cortex (HP:0002753)4.91660322
3Ulnar bowing (HP:0003031)4.83681484
4Rib fusion (HP:0000902)4.62194842
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.60299463
6Hepatocellular necrosis (HP:0001404)4.39326800
7Turricephaly (HP:0000262)4.36454748
8Hepatic necrosis (HP:0002605)4.24318577
9Mitochondrial inheritance (HP:0001427)4.02961780
10Ketoacidosis (HP:0001993)4.01906026
11Acute necrotizing encephalopathy (HP:0006965)3.86157288
12Acute encephalopathy (HP:0006846)3.85054962
13Ketosis (HP:0001946)3.81196191
14Abnormal mitochondria in muscle tissue (HP:0008316)3.79139536
15Poikiloderma (HP:0001029)3.67114324
16Vaginal fistula (HP:0004320)3.66571543
17Mesangial abnormality (HP:0001966)3.60671738
18Annular pancreas (HP:0001734)3.59104792
19Rectal fistula (HP:0100590)3.58914838
20Rectovaginal fistula (HP:0000143)3.58914838
21Intestinal fistula (HP:0100819)3.49234706
22Abnormality of the intrinsic pathway (HP:0010989)3.43684202
23Coronal craniosynostosis (HP:0004440)3.42588952
24Agitation (HP:0000713)3.41477042
25Facial hemangioma (HP:0000329)3.36788186
26Hemorrhage of the eye (HP:0011885)3.28480266
27Squamous cell carcinoma (HP:0002860)3.26157468
28Cerebral edema (HP:0002181)3.23572779
29Increased CSF lactate (HP:0002490)3.23201838
30Renal Fanconi syndrome (HP:0001994)3.21916957
31Joint stiffness (HP:0001387)3.19334182
32Lipid accumulation in hepatocytes (HP:0006561)3.13452558
33Delayed epiphyseal ossification (HP:0002663)3.12378402
34Cerebral palsy (HP:0100021)3.11222909
35Progressive macrocephaly (HP:0004481)3.04089222
36Abnormality of the heme biosynthetic pathway (HP:0010472)3.03530202
37Delayed CNS myelination (HP:0002188)3.02859222
38Hypoglycemic seizures (HP:0002173)3.00264069
39Increased hepatocellular lipid droplets (HP:0006565)2.99312955
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.99152983
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.99152983
42Increased intramyocellular lipid droplets (HP:0012240)2.98889987
43Aplasia of the musculature (HP:0100854)2.96486290
44Increased muscle lipid content (HP:0009058)2.95751037
45Polyphagia (HP:0002591)2.93156947
46Hypoglycemic coma (HP:0001325)2.89992921
47Myopathic facies (HP:0002058)2.89319368
48Generalized aminoaciduria (HP:0002909)2.89068985
49Lactic acidosis (HP:0003128)2.86365902
50Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.84158357
51Rectal prolapse (HP:0002035)2.83771671
52Akinesia (HP:0002304)2.82858178
53Bowed forearm bones (HP:0003956)2.82529396
54Bowing of the arm (HP:0006488)2.82529396
55Glycosuria (HP:0003076)2.78302678
56Abnormality of urine glucose concentration (HP:0011016)2.78302678
57Hyperinsulinemic hypoglycemia (HP:0000825)2.75646086
58Gout (HP:0001997)2.74683317
59Hyperglycinuria (HP:0003108)2.74150279
60Hyperglycinemia (HP:0002154)2.73031021
61Symptomatic seizures (HP:0011145)2.71555664
62Thyroid-stimulating hormone excess (HP:0002925)2.70274632
63Late onset (HP:0003584)2.68652792
64Abnormality of renal resorption (HP:0011038)2.65706050
65Dyschromatopsia (HP:0007641)2.63584753
66Hyperphosphaturia (HP:0003109)2.63538585
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62926011
68Popliteal pterygium (HP:0009756)2.62857928
69Prolonged partial thromboplastin time (HP:0003645)2.59752491
70Brushfield spots (HP:0001088)2.54509698
71Abnormality of serine family amino acid metabolism (HP:0010894)2.54117187
72Abnormality of glycine metabolism (HP:0010895)2.54117187
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49671076
74Breast hypoplasia (HP:0003187)2.49143101
75Respiratory failure (HP:0002878)2.48710972
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48100689
77Dicarboxylic aciduria (HP:0003215)2.48100689
78Lethargy (HP:0001254)2.47308939
79Aplasia/hypoplasia of the uterus (HP:0008684)2.42914468
80Increased serum lactate (HP:0002151)2.42849586
81Abnormality of fatty-acid metabolism (HP:0004359)2.40708040
82Intrahepatic cholestasis (HP:0001406)2.37434313
83Methylmalonic aciduria (HP:0012120)2.34708514
84Failure to thrive in infancy (HP:0001531)2.33945333
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31659719
86Vomiting (HP:0002013)2.31335690
87Anteriorly placed anus (HP:0001545)2.31042242
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.30889212
89Atrioventricular block (HP:0001678)2.30724494
90Optic disc pallor (HP:0000543)2.29281506
91Abnormal pancreas size (HP:0012094)2.28195074
92Hypobetalipoproteinemia (HP:0003563)2.28186777
93Broad distal phalanx of finger (HP:0009836)2.26598724
94Cervical subluxation (HP:0003308)2.26278393
95Abnormal rod and cone electroretinograms (HP:0008323)2.22670260
96Conjugated hyperbilirubinemia (HP:0002908)2.22212934
97Thin ribs (HP:0000883)2.20863248
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.20451972
99Abnormality of the costochondral junction (HP:0000919)2.19822000
100Protrusio acetabuli (HP:0003179)2.18996237
101Male infertility (HP:0003251)2.18392579
102Ragged-red muscle fibers (HP:0003200)2.18033013
103Hyperammonemia (HP:0001987)2.17685492
104Progressive muscle weakness (HP:0003323)2.17637195
105Congenital stationary night blindness (HP:0007642)2.17628891
106Patellar aplasia (HP:0006443)2.17329201
107Capillary hemangiomas (HP:0005306)2.17163479
108Atelectasis (HP:0100750)2.16906204
109Joint hemorrhage (HP:0005261)2.16692336
110Aplasia/Hypoplasia of the patella (HP:0006498)2.16322282
111Choanal stenosis (HP:0000452)2.16117431
112Deep venous thrombosis (HP:0002625)2.15553021
113Leukodystrophy (HP:0002415)2.15544745
114Hypoplasia of the uterus (HP:0000013)2.15401672
115Restlessness (HP:0000711)2.14434454
116Abnormality of cells of the erythroid lineage (HP:0012130)2.13809035
117Abnormal number of erythroid precursors (HP:0012131)2.13637301
118Sleep apnea (HP:0010535)2.11925729
119Neonatal onset (HP:0003623)2.11759122
120Slender long bone (HP:0003100)2.10858508
121Genu recurvatum (HP:0002816)2.10161373
122Bulbar palsy (HP:0001283)2.08900564
123Hypothermia (HP:0002045)2.07941601
124Exertional dyspnea (HP:0002875)2.05163685
125Attenuation of retinal blood vessels (HP:0007843)2.04618457
126Xanthomatosis (HP:0000991)2.03283535
127Hyperthyroidism (HP:0000836)2.03192636
128Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02883522
129Abnormality of polysaccharide metabolism (HP:0011012)2.02883522
130Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02883522
131Abnormal urine phosphate concentration (HP:0012599)2.02195478
132Hypoalbuminemia (HP:0003073)2.02039454
133Abnormal albumin level (HP:0012116)2.02039454
134Exercise intolerance (HP:0003546)2.01610729
135Absent thumb (HP:0009777)2.00753990
136Macrocytic anemia (HP:0001972)2.00307658
1373-Methylglutaconic aciduria (HP:0003535)2.00136210
138Hyperacusis (HP:0010780)1.99121281
139Metabolic acidosis (HP:0001942)1.98559048
140Mucopolysacchariduria (HP:0008155)1.98533716
141Urinary glycosaminoglycan excretion (HP:0003541)1.98533716
142CNS demyelination (HP:0007305)1.98175126
143Opisthotonus (HP:0002179)1.95533241
144Fetal akinesia sequence (HP:0001989)1.95438091
145Birth length less than 3rd percentile (HP:0003561)1.95260108
146Facial diplegia (HP:0001349)1.93573995
147Easy fatigability (HP:0003388)1.93428353
148Emotional lability (HP:0000712)1.93039901
149Abnormality of purine metabolism (HP:0004352)1.93031817
150Hyperuricemia (HP:0002149)1.90526253
151Increased purine levels (HP:0004368)1.90526253
152Stridor (HP:0010307)1.89818588
153Esotropia (HP:0000565)1.89550710
154Hypophosphatemic rickets (HP:0004912)1.89121298
155Microretrognathia (HP:0000308)1.88837296
156Abnormal trabecular bone morphology (HP:0100671)1.87763191
157Zonular cataract (HP:0010920)1.85516908
158Abnormality of the nasal mucosa (HP:0000433)1.85401931
159Vertebral compression fractures (HP:0002953)1.85342915
160Achilles tendon contracture (HP:0001771)1.84644123
161Poor suck (HP:0002033)1.84386527
162Pterygium (HP:0001059)1.83963344
163Hyperbilirubinemia (HP:0002904)1.83676254
164Nasal polyposis (HP:0100582)1.80589655
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80340100
166Abnormality of the thoracic spine (HP:0100711)1.79682809
167Truncus arteriosus (HP:0001660)1.79577495
168Generalized amyotrophy (HP:0003700)1.79498874
169Abnormality of serum amino acid levels (HP:0003112)1.79257714
170Ridged nail (HP:0001807)1.78933852
171Abnormal hemoglobin (HP:0011902)1.78687170
172Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78356636
173Hypertensive crisis (HP:0100735)1.77961727
174Amniotic constriction ring (HP:0009775)1.77939772
175Abnormality of placental membranes (HP:0011409)1.77939772
176Concave nail (HP:0001598)1.77832038
177Premature graying of hair (HP:0002216)1.77190392
178Hypoplastic heart (HP:0001961)1.75815641
179Renal tubular dysfunction (HP:0000124)1.74947975
180Pheochromocytoma (HP:0002666)1.74417628
181Cholelithiasis (HP:0001081)1.74303941
182Fat malabsorption (HP:0002630)1.74017301
183Reticulocytopenia (HP:0001896)1.73523597
184Enlarged epiphyses (HP:0010580)1.72681814
185Elbow flexion contracture (HP:0002987)1.72667066
186Abnormal epiphyseal ossification (HP:0010656)1.69586564
187Widely patent fontanelles and sutures (HP:0004492)1.68833529
188Abnormal atrioventricular conduction (HP:0005150)1.68748695
189Reduced antithrombin III activity (HP:0001976)1.68497407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.07702378
2TRIB35.00272523
3TLK14.50878915
4SMG13.84893744
5BCKDK3.70745681
6EPHB23.70048265
7STK163.69872494
8MAPK152.75775682
9CASK2.34053213
10IRAK32.30358658
11TNIK2.29864980
12INSRR2.27121352
13TESK22.25327430
14CDK192.16101045
15EEF2K2.15106242
16ICK2.09200291
17WNK42.02287443
18PRKD31.83320435
19UHMK11.79768136
20MAP2K31.79553897
21EPHA21.75260513
22ARAF1.73584373
23VRK21.63465445
24MAP2K71.50176217
25PIM21.50063074
26BMPR1B1.45980219
27PRKD21.45090444
28IRAK21.38482614
29OXSR11.38086499
30ERN11.35371303
31GRK61.33749061
32TESK11.33414098
33CCNB11.31032769
34PDPK11.28459946
35TAOK31.27948152
36LMTK21.19623539
37DYRK21.13960406
38STK391.12719353
39DYRK31.12030104
40PRPF4B1.11789098
41MAP2K21.11617249
42NME11.10706378
43PKN21.10503095
44PIK3CG1.08643449
45MYLK1.07938137
46ACVR1B1.06396027
47VRK11.05246539
48RPS6KA21.03688633
49TAOK21.03402378
50MTOR0.98925270
51RIPK10.98752524
52MAP3K120.97380155
53PBK0.97155461
54PKN10.95057196
55MUSK0.93966250
56ERBB20.93666169
57PHKG20.92282567
58PHKG10.92282567
59BLK0.91376333
60CDK40.91344307
61MAPK110.91236766
62FES0.91020622
63CDK120.90751984
64RPS6KC10.89531258
65RPS6KL10.89531258
66ABL20.86111463
67CSNK1G30.85850360
68MAPK120.85307704
69PAK40.82378241
70DAPK30.81161118
71BMX0.80928505
72NME20.80009859
73DYRK1B0.79265452
74TTN0.78730152
75CDC42BPA0.77325975
76TBK10.75715944
77IRAK10.74893285
78RPS6KA60.73961188
79ADRBK10.73898771
80TAF10.73371481
81NEK20.72641466
82FER0.72462314
83MAP3K10.71566609
84TAOK10.70321669
85SIK10.70293576
86CAMK10.68249880
87LRRK20.66709539
88CAMK2B0.64788068
89CSNK1G10.64716943
90PAK10.62995771
91ZAP700.62923719
92MELK0.60401446
93MAPK130.59322331
94MARK20.59151202
95CHEK20.59047115
96MARK10.58715848
97SRPK10.58586276
98ILK0.58217990
99PDK20.57692860
100CDK80.57631247
101MAP3K30.56752047
102PTK60.56661459
103DYRK1A0.55627990
104DDR20.54807940
105RPS6KB20.54529376
106DAPK20.54244231
107AKT20.53665612
108MAP3K20.52850260
109HIPK20.52746583
110CDK70.52450221
111MAPKAPK30.52397280
112PRKCZ0.52072180
113FLT30.50625500
114KDR0.49644170
115CDK11A0.49400525
116MAP3K40.48638388
117MAP2K60.47993692
118CAMK2D0.47971937
119MAP2K40.47917829
120PINK10.47817522
121MAP3K80.47719953
122MAPKAPK50.47446255
123PRKD10.46967970
124PTK20.46717332
125ZAK0.46590777
126CDK150.46424300
127GRK70.45751119
128YES10.45675462
129CAMK2A0.45187432
130MAP3K110.44326939
131SIK30.44052367
132SIK20.42672464
133CSNK1G20.42573112
134PASK0.41742715
135PRKCI0.41594499
136TGFBR10.40518304
137ADRBK20.40457189
138CDK50.40411573
139BUB10.40138570
140CAMK2G0.38860542
141CAMK1D0.38076633
142MAP3K90.37225406
143CSNK1A1L0.36758570
144CDK140.36608433
145BRAF0.35598222
146CDK180.35053723
147BCR0.34945734
148AURKA0.34561486
149NTRK20.34476379
150RPS6KA50.34199897
151CSNK1A10.34140557
152PRKACA0.33907064
153IRAK40.33540858
154MAP3K100.33076137
155PRKCG0.32985016
156LIMK10.32483572
157MST1R0.32376420
158MET0.31717800
159MAPK40.29278222
160RPS6KA10.28779108
161SGK2230.28744512
162SGK4940.28744512
163GRK50.28681212
164KIT0.27791855
165MAPK80.27779677
166KSR20.27165278
167MKNK20.26629945
168TIE10.26085536
169GRK10.25958372
170NTRK30.25780844
171DAPK10.25173750
172ATR0.24837018

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.49947195
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.41467005
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.30676282
4Oxidative phosphorylation_Homo sapiens_hsa001903.16721635
5Protein export_Homo sapiens_hsa030603.07128682
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.98185235
7Ribosome_Homo sapiens_hsa030102.70938436
8Butanoate metabolism_Homo sapiens_hsa006502.63717863
9Fatty acid elongation_Homo sapiens_hsa000622.62340963
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53531114
11Parkinsons disease_Homo sapiens_hsa050122.50726897
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43470073
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.26743735
14Sulfur metabolism_Homo sapiens_hsa009202.14639732
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12926401
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06500319
17Sulfur relay system_Homo sapiens_hsa041222.04232624
18Propanoate metabolism_Homo sapiens_hsa006402.02374739
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97790691
20Tryptophan metabolism_Homo sapiens_hsa003801.95463988
21Fatty acid degradation_Homo sapiens_hsa000711.87698979
22Alzheimers disease_Homo sapiens_hsa050101.85689364
23Base excision repair_Homo sapiens_hsa034101.84452668
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83090647
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81894531
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69221040
27Peroxisome_Homo sapiens_hsa041461.69134154
28Notch signaling pathway_Homo sapiens_hsa043301.67448320
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66477239
30Folate biosynthesis_Homo sapiens_hsa007901.63236147
31Bladder cancer_Homo sapiens_hsa052191.62839224
32Fatty acid metabolism_Homo sapiens_hsa012121.53743925
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52194527
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51363709
35Huntingtons disease_Homo sapiens_hsa050161.48927766
36Pyruvate metabolism_Homo sapiens_hsa006201.46474899
37Histidine metabolism_Homo sapiens_hsa003401.40125508
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.37532550
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36450080
40Phototransduction_Homo sapiens_hsa047441.34983128
41Fat digestion and absorption_Homo sapiens_hsa049751.34906397
42beta-Alanine metabolism_Homo sapiens_hsa004101.34768659
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30140053
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27266891
45Hedgehog signaling pathway_Homo sapiens_hsa043401.27162322
46DNA replication_Homo sapiens_hsa030301.26938353
47VEGF signaling pathway_Homo sapiens_hsa043701.23924287
48Tyrosine metabolism_Homo sapiens_hsa003501.21657525
49Lysosome_Homo sapiens_hsa041421.21380398
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19621402
51Retinol metabolism_Homo sapiens_hsa008301.19059031
52Arginine biosynthesis_Homo sapiens_hsa002201.12554904
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.12180947
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07348708
55Selenocompound metabolism_Homo sapiens_hsa004501.02392902
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02135256
57Other glycan degradation_Homo sapiens_hsa005111.01451697
58Phenylalanine metabolism_Homo sapiens_hsa003601.00273075
59mTOR signaling pathway_Homo sapiens_hsa041500.99773202
60Acute myeloid leukemia_Homo sapiens_hsa052210.96700998
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96386437
62Basal cell carcinoma_Homo sapiens_hsa052170.96254166
63Chemical carcinogenesis_Homo sapiens_hsa052040.95454271
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.93851682
65Arginine and proline metabolism_Homo sapiens_hsa003300.93528133
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92807852
67Cardiac muscle contraction_Homo sapiens_hsa042600.92776941
68Complement and coagulation cascades_Homo sapiens_hsa046100.92093519
69Metabolic pathways_Homo sapiens_hsa011000.91608947
70Carbon metabolism_Homo sapiens_hsa012000.90838549
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89584400
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89465089
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89367230
74Vibrio cholerae infection_Homo sapiens_hsa051100.86967650
75PPAR signaling pathway_Homo sapiens_hsa033200.83332066
76Starch and sucrose metabolism_Homo sapiens_hsa005000.83243173
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81351610
78Steroid biosynthesis_Homo sapiens_hsa001000.78748664
79Fanconi anemia pathway_Homo sapiens_hsa034600.76522620
80Non-small cell lung cancer_Homo sapiens_hsa052230.76443940
81Chronic myeloid leukemia_Homo sapiens_hsa052200.76045719
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.74679646
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73884351
84Lysine degradation_Homo sapiens_hsa003100.73748153
85Pancreatic secretion_Homo sapiens_hsa049720.73536440
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.73508426
87Collecting duct acid secretion_Homo sapiens_hsa049660.69562411
88Glutathione metabolism_Homo sapiens_hsa004800.69381660
89Linoleic acid metabolism_Homo sapiens_hsa005910.69023836
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68860523
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68495245
92N-Glycan biosynthesis_Homo sapiens_hsa005100.67269438
93Biosynthesis of amino acids_Homo sapiens_hsa012300.66290968
94Insulin secretion_Homo sapiens_hsa049110.65944148
95Endocytosis_Homo sapiens_hsa041440.60100800
96AMPK signaling pathway_Homo sapiens_hsa041520.60011085
97Inositol phosphate metabolism_Homo sapiens_hsa005620.59827858
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.59741236
99Proteasome_Homo sapiens_hsa030500.59125846
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.59101397
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58314238
102Vitamin digestion and absorption_Homo sapiens_hsa049770.56737675
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56689404
104Endometrial cancer_Homo sapiens_hsa052130.56491466
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56424869
106Insulin resistance_Homo sapiens_hsa049310.56378736
107Arachidonic acid metabolism_Homo sapiens_hsa005900.56079982
108Pancreatic cancer_Homo sapiens_hsa052120.55584317
109Hepatitis C_Homo sapiens_hsa051600.55528649
110Insulin signaling pathway_Homo sapiens_hsa049100.54480270
111Glycerolipid metabolism_Homo sapiens_hsa005610.52003349
112Prion diseases_Homo sapiens_hsa050200.51908997
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51240018
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50800256
115Apoptosis_Homo sapiens_hsa042100.49988144
116Bile secretion_Homo sapiens_hsa049760.49711910
117Melanogenesis_Homo sapiens_hsa049160.48896611
118Nitrogen metabolism_Homo sapiens_hsa009100.48414194
119Hippo signaling pathway_Homo sapiens_hsa043900.47772121
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46903083
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.46831562
122HTLV-I infection_Homo sapiens_hsa051660.45457372
123Thyroid cancer_Homo sapiens_hsa052160.45412372
124ABC transporters_Homo sapiens_hsa020100.44790190
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42620212
126GABAergic synapse_Homo sapiens_hsa047270.42549658
127Regulation of autophagy_Homo sapiens_hsa041400.42173747
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41177632
129Pyrimidine metabolism_Homo sapiens_hsa002400.40984696
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38760889
131RNA polymerase_Homo sapiens_hsa030200.38455051
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37348402
133Caffeine metabolism_Homo sapiens_hsa002320.36116471
134Sphingolipid metabolism_Homo sapiens_hsa006000.35602503
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34639677
136Pentose phosphate pathway_Homo sapiens_hsa000300.34225778
137Galactose metabolism_Homo sapiens_hsa000520.34158226
138Vitamin B6 metabolism_Homo sapiens_hsa007500.33753555
139Protein digestion and absorption_Homo sapiens_hsa049740.33371333
140Cocaine addiction_Homo sapiens_hsa050300.32953894
141Cell cycle_Homo sapiens_hsa041100.31821646
142Purine metabolism_Homo sapiens_hsa002300.31565781
143Melanoma_Homo sapiens_hsa052180.31111005
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28809628
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28172848
146Small cell lung cancer_Homo sapiens_hsa052220.27283324
147Taste transduction_Homo sapiens_hsa047420.26863589
148B cell receptor signaling pathway_Homo sapiens_hsa046620.26824719
149Synaptic vesicle cycle_Homo sapiens_hsa047210.26724639
150Nicotine addiction_Homo sapiens_hsa050330.26317675
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26190671
152Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25614254
153One carbon pool by folate_Homo sapiens_hsa006700.24845273
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24481306
155Alcoholism_Homo sapiens_hsa050340.24461437
156Ether lipid metabolism_Homo sapiens_hsa005650.24170610
157Fructose and mannose metabolism_Homo sapiens_hsa000510.23069168
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22408307
159RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21693879
160Glucagon signaling pathway_Homo sapiens_hsa049220.20333179
161Glioma_Homo sapiens_hsa052140.19474690
162Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19450222
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.18376645

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