JOSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)4.81176631
2lysine catabolic process (GO:0006554)4.81176631
3alpha-linolenic acid metabolic process (GO:0036109)4.55072228
4regulation of fatty acid beta-oxidation (GO:0031998)4.41147782
5positive regulation of fatty acid beta-oxidation (GO:0032000)4.29796417
6dicarboxylic acid biosynthetic process (GO:0043650)4.21314555
7urea cycle (GO:0000050)4.18744063
8urea metabolic process (GO:0019627)4.18744063
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.16048810
10L-phenylalanine metabolic process (GO:0006558)4.16048810
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.05743746
12L-phenylalanine catabolic process (GO:0006559)4.05743746
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.97768615
14negative regulation of fibrinolysis (GO:0051918)3.94874726
15embryonic process involved in female pregnancy (GO:0060136)3.92523784
16negative regulation of sodium ion transport (GO:0010766)3.91397291
17cysteine metabolic process (GO:0006534)3.78314501
18kynurenine metabolic process (GO:0070189)3.67185352
19glutamate metabolic process (GO:0006536)3.63990242
20regulation of cholesterol homeostasis (GO:2000188)3.63671290
21nitrogen cycle metabolic process (GO:0071941)3.61329670
22regulation of fatty acid oxidation (GO:0046320)3.55673732
23response to muramyl dipeptide (GO:0032495)3.51816422
24response to laminar fluid shear stress (GO:0034616)3.50969013
25protein localization to endosome (GO:0036010)3.50180514
26positive regulation of lipid catabolic process (GO:0050996)3.50085374
27hypotonic response (GO:0006971)3.48416851
28sulfur amino acid catabolic process (GO:0000098)3.48064469
29protein carboxylation (GO:0018214)3.44906734
30peptidyl-glutamic acid carboxylation (GO:0017187)3.44906734
31high-density lipoprotein particle remodeling (GO:0034375)3.43556610
32one-carbon metabolic process (GO:0006730)3.41823044
33aspartate family amino acid catabolic process (GO:0009068)3.40396367
34aromatic amino acid family catabolic process (GO:0009074)3.39690871
352-oxoglutarate metabolic process (GO:0006103)3.39451815
36positive regulation of fatty acid oxidation (GO:0046321)3.38979483
37fatty acid transmembrane transport (GO:1902001)3.33337726
38bile acid biosynthetic process (GO:0006699)3.33178473
39regulation of vitamin D biosynthetic process (GO:0060556)3.32862436
40carnitine shuttle (GO:0006853)3.31412870
41regulation of fibrinolysis (GO:0051917)3.29674633
42negative regulation of sterol transport (GO:0032372)3.29639647
43negative regulation of cholesterol transport (GO:0032375)3.29639647
44oxaloacetate metabolic process (GO:0006107)3.28261920
45NIK/NF-kappaB signaling (GO:0038061)3.27163075
46regulation of triglyceride catabolic process (GO:0010896)3.24744009
47negative regulation of cell size (GO:0045792)3.23074355
48response to peptidoglycan (GO:0032494)3.22618473
49glyoxylate metabolic process (GO:0046487)3.22043680
50peptidyl-lysine dimethylation (GO:0018027)3.19025605
51germinal center formation (GO:0002467)3.18958723
52regulation of protein activation cascade (GO:2000257)3.17905207
53ethanol oxidation (GO:0006069)3.15061824
54regulation of vitamin metabolic process (GO:0030656)3.14432322
55cellular ketone body metabolic process (GO:0046950)3.13296163
56complement activation, alternative pathway (GO:0006957)3.09106384
57valine metabolic process (GO:0006573)3.07682122
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07517653
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05670988
60glycine metabolic process (GO:0006544)3.02617635
61reverse cholesterol transport (GO:0043691)3.02544310
62amino-acid betaine metabolic process (GO:0006577)3.02186202
63tolerance induction (GO:0002507)3.02049363
64cellular modified amino acid catabolic process (GO:0042219)3.01427032
65folic acid-containing compound biosynthetic process (GO:0009396)2.99743335
66acylglycerol homeostasis (GO:0055090)2.97643306
67triglyceride homeostasis (GO:0070328)2.97643306
684-hydroxyproline metabolic process (GO:0019471)2.96040176
69serine family amino acid catabolic process (GO:0009071)2.95550242
70mannose metabolic process (GO:0006013)2.95077987
71pinocytosis (GO:0006907)2.94570024
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93392465
73regulation of complement activation (GO:0030449)2.93234562
74plasma lipoprotein particle clearance (GO:0034381)2.91716894
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88802389
76negative regulation of lipase activity (GO:0060192)2.87180364
77alpha-amino acid catabolic process (GO:1901606)2.86757690
78modulation by symbiont of host cellular process (GO:0044068)2.86112375
79regulation of lipid catabolic process (GO:0050994)2.85243770
80regulation of translational fidelity (GO:0006450)2.82385648
81negative regulation of lipid transport (GO:0032369)2.81238588
82acylglycerol catabolic process (GO:0046464)2.79852300
83neutral lipid catabolic process (GO:0046461)2.79852300
84homocysteine metabolic process (GO:0050667)2.78771027
85ketone body metabolic process (GO:1902224)2.78467803
86negative regulation of fatty acid transport (GO:2000192)2.77912449
87indole-containing compound catabolic process (GO:0042436)2.77738168
88indolalkylamine catabolic process (GO:0046218)2.77738168
89tryptophan catabolic process (GO:0006569)2.77738168
90acetyl-CoA metabolic process (GO:0006084)2.77225759
91positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.76693937
92epoxygenase P450 pathway (GO:0019373)2.76249094
93plasma lipoprotein particle remodeling (GO:0034369)2.74206650
94protein-lipid complex remodeling (GO:0034368)2.74206650
95macromolecular complex remodeling (GO:0034367)2.74206650
96bile acid metabolic process (GO:0008206)2.72750797
97regulation of translational termination (GO:0006449)2.72202004
98protein-lipid complex assembly (GO:0065005)2.71886136
99imidazole-containing compound metabolic process (GO:0052803)2.71885421
100regulation of early endosome to late endosome transport (GO:2000641)2.71469245
101positive regulation of extracellular matrix organization (GO:1903055)2.69202901
102negative regulation of fatty acid metabolic process (GO:0045922)2.67198019
103phospholipid homeostasis (GO:0055091)2.67062846
104plasma lipoprotein particle assembly (GO:0034377)2.65868096
105low-density lipoprotein particle clearance (GO:0034383)2.65843971
106cellular amino acid catabolic process (GO:0009063)2.65015970
107negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64391510
108negative regulation of interleukin-8 production (GO:0032717)2.64312750
109short-chain fatty acid metabolic process (GO:0046459)2.63464995
110positive regulation of triglyceride metabolic process (GO:0090208)2.62759126
111stress fiber assembly (GO:0043149)2.62522815
112skin morphogenesis (GO:0043589)2.61555407
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.61412584
114drug catabolic process (GO:0042737)2.61314482
115locomotory exploration behavior (GO:0035641)2.61006678
116tryptophan metabolic process (GO:0006568)2.60972117
117regulation of fatty acid biosynthetic process (GO:0042304)2.60761336
118negative regulation of erythrocyte differentiation (GO:0045647)2.60641772
119tricarboxylic acid metabolic process (GO:0072350)2.60279548
120regulation of NFAT protein import into nucleus (GO:0051532)2.60090786
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.59123053
122serine family amino acid metabolic process (GO:0009069)2.58816478
123alanine transport (GO:0032328)2.58798363
124carnitine transmembrane transport (GO:1902603)2.58772445
125negative regulation of fatty acid biosynthetic process (GO:0045717)2.58124683
126antigen processing and presentation of endogenous antigen (GO:0019883)2.58090313
127dicarboxylic acid catabolic process (GO:0043649)2.56915156
128negative regulation of cell killing (GO:0031342)2.55128877
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55128877
130activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52720668
131myeloid dendritic cell differentiation (GO:0043011)2.52256342
132positive regulation of gamma-delta T cell activation (GO:0046645)2.51744643
133cellular extravasation (GO:0045123)2.51230728
134regulation of integrin activation (GO:0033623)2.51039882
135negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.50718690
136necroptotic process (GO:0070266)2.48204060
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46751743
138activation of MAPKKK activity (GO:0000185)2.45266716
139modulation by virus of host process (GO:0019054)2.44706731
140regulation of T-helper 2 cell differentiation (GO:0045628)2.43056686
1413-UTR-mediated mRNA stabilization (GO:0070935)2.42416853
142regulation of transforming growth factor beta1 production (GO:0032908)2.41463916
143positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.41230653
144positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40775369
145CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.40204861
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.40046216
147establishment of endothelial barrier (GO:0061028)2.38954985
148positive thymic T cell selection (GO:0045059)2.38709182
149negative regulation of interleukin-12 production (GO:0032695)2.34516210
150thymic T cell selection (GO:0045061)2.33012748
151endothelial cell chemotaxis (GO:0035767)2.29890842
152regulation of anoikis (GO:2000209)2.29261212
153regulation of extracellular matrix disassembly (GO:0010715)2.28671544
154cell-substrate junction assembly (GO:0007044)2.28220500
155glycosphingolipid catabolic process (GO:0046479)2.27836544
156positive regulation of Cdc42 GTPase activity (GO:0043089)2.25888528
157negative regulation of anoikis (GO:2000811)2.25587116
158negative regulation of toll-like receptor signaling pathway (GO:0034122)2.24021394
159positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23422508
160activation of JUN kinase activity (GO:0007257)2.23373975
161regulation of apoptotic process involved in morphogenesis (GO:1902337)2.22628790
162regulation of gamma-delta T cell activation (GO:0046643)2.22479712
163positive regulation of receptor recycling (GO:0001921)2.22352921
164endocytic recycling (GO:0032456)2.22343526
165regulation of T-helper 1 cell differentiation (GO:0045625)2.22242223
166decidualization (GO:0046697)2.22201175
167hemidesmosome assembly (GO:0031581)2.19996763
168cellular response to thyroid hormone stimulus (GO:0097067)2.19459754
169regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19115244
170cell adhesion mediated by integrin (GO:0033627)2.18990076
171myeloid dendritic cell activation (GO:0001773)2.15953852
172cellular response to arsenic-containing substance (GO:0071243)2.15775928
173positive regulation of blood vessel endothelial cell migration (GO:0043536)2.15219185
174mRNA transcription (GO:0009299)2.14220617
175activation of Rac GTPase activity (GO:0032863)2.13860207
176regulation of necroptotic process (GO:0060544)2.13587825
177T cell selection (GO:0045058)2.12197491
178negative regulation of viral release from host cell (GO:1902187)2.11752847
179response to fluid shear stress (GO:0034405)2.11450026
180COPI coating of Golgi vesicle (GO:0048205)2.11350853
181Golgi transport vesicle coating (GO:0048200)2.11350853
182T-helper 1 type immune response (GO:0042088)2.09779351
183macrophage activation involved in immune response (GO:0002281)2.09686983
184glycolipid catabolic process (GO:0019377)2.09684539
185positive regulation of keratinocyte differentiation (GO:0045618)2.09328802
186modulation by symbiont of host defense response (GO:0052031)2.08740717
187modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.08740717
188modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.08740717
189positive regulation by organism of defense response of other organism involved in symbiotic interact2.08740717
190modulation by symbiont of host immune response (GO:0052553)2.08740717
191positive regulation by symbiont of host defense response (GO:0052509)2.08740717
192focal adhesion assembly (GO:0048041)2.08634353
193cell-substrate adherens junction assembly (GO:0007045)2.08634353
194TRIF-dependent toll-like receptor signaling pathway (GO:0035666)2.07864822
195programmed necrotic cell death (GO:0097300)2.07683994
196barbed-end actin filament capping (GO:0051016)2.07543592
197positive regulation of chemokine biosynthetic process (GO:0045080)2.07390662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.85883110
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.67859327
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.23179316
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.18916455
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.65750220
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.63031156
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.48922308
8ZNF263_19887448_ChIP-Seq_K562_Human3.14587444
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77546454
10CLOCK_20551151_ChIP-Seq_293T_Human2.61125352
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.60855206
12MYC_22102868_ChIP-Seq_BL_Human2.56695699
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53673514
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.42960226
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.35881092
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35547681
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.29500981
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23004230
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21971373
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.21789374
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17353684
22TCF7_22412390_ChIP-Seq_EML_Mouse2.13573007
23KDM2B_26808549_Chip-Seq_DND41_Human2.09790453
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02467122
25VDR_24763502_ChIP-Seq_THP-1_Human2.00850784
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00275759
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96928136
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96700145
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.89898791
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89796698
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88034792
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78153043
33EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77851918
34LXR_22292898_ChIP-Seq_THP-1_Human1.74505878
35KDM2B_26808549_Chip-Seq_K562_Human1.73067210
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71805378
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.68544292
38* ATF3_27146783_Chip-Seq_COLON_Human1.67525233
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66179953
40P300_27058665_Chip-Seq_ZR-75-30cells_Human1.65768063
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65105276
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.64947375
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64805708
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64218831
45* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62888062
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61809020
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.59095571
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57091993
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56422934
50FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.54595494
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54213126
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54001534
53GATA1_19941826_ChIP-Seq_K562_Human1.53616699
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53430180
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.50901419
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.48572854
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48542617
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48340376
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46287263
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46019522
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.45933609
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.45633556
63CREB1_26743006_Chip-Seq_LNCaP_Human1.45377682
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.43947799
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.43426720
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42264063
67* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41338320
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39723753
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39723753
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38912993
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37610070
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37276388
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35953621
74RUNX_20019798_ChIP-Seq_JUKART_Human1.35899364
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.35220964
76GATA1_22025678_ChIP-Seq_K562_Human1.31095829
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30224113
78* MAF_26560356_Chip-Seq_TH2_Human1.29811881
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.25868436
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25166893
81NCOR1_26117541_ChIP-Seq_K562_Human1.25075605
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24207547
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24001270
84* MYB_26560356_Chip-Seq_TH1_Human1.23515664
85FOXM1_23109430_ChIP-Seq_U2OS_Human1.22390258
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22215335
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21781072
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.21680076
89* MYB_26560356_Chip-Seq_TH2_Human1.19047286
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15206632
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14911236
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14724833
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13849776
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13517192
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13384867
96* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12947653
97SPI1_23127762_ChIP-Seq_K562_Human1.12338969
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.12279902
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11570020
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.09992601
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.09249237
102CHD1_26751641_Chip-Seq_LNCaP_Human1.09201783
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09090780
104FOXO3_23340844_ChIP-Seq_DLD1_Human1.08424492
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.08359603
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07984006
107TP53_22127205_ChIP-Seq_IMR90_Human1.07130259
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06529596
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06466847
110* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05473219
111* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05264857
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.05237307
113BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04882318
114VDR_21846776_ChIP-Seq_THP-1_Human1.04108819
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03455092
116AR_21909140_ChIP-Seq_LNCAP_Human1.01427365
117PU_27001747_Chip-Seq_BMDM_Mouse1.00834311
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99924828
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99890113
120SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99580752
121* HNF4A_19822575_ChIP-Seq_HepG2_Human0.98633435
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98497897
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98482901
124GATA2_19941826_ChIP-Seq_K562_Human0.97157381
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96784287
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95997755
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95818099
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.95769752
129* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95055555
130CTCF_21964334_Chip-Seq_Bcells_Human0.94469067
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94255599
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94112398
133* UTX_26944678_Chip-Seq_JUKART_Human0.93695381
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92250059
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.92133137
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.92133137
137GATA6_25053715_ChIP-Seq_YYC3_Human0.91100779
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90681035
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90282848
140SCL_19346495_ChIP-Seq_HPC-7_Human0.89660615
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86230367
142MAF_26560356_Chip-Seq_TH1_Human0.85878895
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84634102
144* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83920215
145SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83403586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.57778270
2MP0005360_urolithiasis4.77226423
3MP0005085_abnormal_gallbladder_physiolo4.21418758
4MP0005365_abnormal_bile_salt4.01560439
5MP0003705_abnormal_hypodermis_morpholog3.99696830
6MP0008875_abnormal_xenobiotic_pharmacok3.60256933
7MP0010234_abnormal_vibrissa_follicle3.00757178
8MP0002877_abnormal_melanocyte_morpholog2.94106584
9MP0003436_decreased_susceptibility_to2.85353937
10MP0010329_abnormal_lipoprotein_level2.84865946
11MP0004859_abnormal_synaptic_plasticity2.75008687
12MP0003252_abnormal_bile_duct2.44499022
13MP0010352_gastrointestinal_tract_polyps2.34955480
14MP0004947_skin_inflammation2.32876850
15MP0003656_abnormal_erythrocyte_physiolo2.30134346
16MP0002822_catalepsy2.20019975
17MP0005083_abnormal_biliary_tract2.17833856
18MP0003763_abnormal_thymus_physiology2.12628955
19MP0005451_abnormal_body_composition2.04096434
20MP0003566_abnormal_cell_adhesion2.02413910
21MP0005058_abnormal_lysosome_morphology1.97076531
22MP0009780_abnormal_chondrocyte_physiolo1.88021817
23MP0003453_abnormal_keratinocyte_physiol1.85765661
24MP0004130_abnormal_muscle_cell1.85337392
25MP0009278_abnormal_bone_marrow1.84096042
26MP0005000_abnormal_immune_tolerance1.82812862
27MP0010155_abnormal_intestine_physiology1.82676664
28MP0000609_abnormal_liver_physiology1.81157798
29MP0008961_abnormal_basal_metabolism1.80779205
30MP0005409_darkened_coat_color1.79015179
31MP0003724_increased_susceptibility_to1.75351305
32MP0009840_abnormal_foam_cell1.71006382
33MP0008260_abnormal_autophagy1.70360891
34MP0001873_stomach_inflammation1.70308113
35MP0004185_abnormal_adipocyte_glucose1.69418628
36MP0000685_abnormal_immune_system1.67627807
37MP0001666_abnormal_nutrient_absorption1.66344256
38MP0001835_abnormal_antigen_presentation1.65559989
39MP0001851_eye_inflammation1.63508327
40MP0002118_abnormal_lipid_homeostasis1.63286585
41MP0003300_gastrointestinal_ulcer1.61418748
42MP0002419_abnormal_innate_immunity1.61404253
43MP0009333_abnormal_splenocyte_physiolog1.61173184
44MP0003172_abnormal_lysosome_physiology1.58996503
45MP0003806_abnormal_nucleotide_metabolis1.56789093
46MP0005332_abnormal_amino_acid1.56615342
47MP0002148_abnormal_hypersensitivity_rea1.47311691
48MP0005025_abnormal_response_to1.46863781
49MP0001790_abnormal_immune_system1.46787382
50MP0005387_immune_system_phenotype1.46787382
51MP0000858_altered_metastatic_potential1.45169216
52MP0001800_abnormal_humoral_immune1.44853069
53MP0003191_abnormal_cellular_cholesterol1.44604890
54MP0002452_abnormal_antigen_presenting1.42369798
55MP0002998_abnormal_bone_remodeling1.40464512
56MP0003828_pulmonary_edema1.39450929
57MP0002723_abnormal_immune_serum1.38935817
58MP0001533_abnormal_skeleton_physiology1.38019086
59MP0002009_preneoplasia1.36237516
60MP0005666_abnormal_adipose_tissue1.35452628
61MP0002138_abnormal_hepatobiliary_system1.34425845
62MP0005319_abnormal_enzyme/_coenzyme1.34223052
63MP0006082_CNS_inflammation1.33262759
64MP0002837_dystrophic_cardiac_calcinosis1.32060423
65MP0002420_abnormal_adaptive_immunity1.30234316
66MP0001853_heart_inflammation1.28391979
67MP0001819_abnormal_immune_cell1.27953507
68MP0003448_altered_tumor_morphology1.25381896
69MP0000604_amyloidosis1.23715191
70MP0002933_joint_inflammation1.21114511
71MP0003045_fibrosis1.21108493
72MP0005076_abnormal_cell_differentiation1.19725736
73MP0000598_abnormal_liver_morphology1.19028812
74MP0009785_altered_susceptibility_to1.17808146
75MP0002405_respiratory_system_inflammati1.16859593
76MP0002398_abnormal_bone_marrow1.16565396
77MP0003868_abnormal_feces_composition1.16144628
78MP0002060_abnormal_skin_morphology1.15325743
79MP0005187_abnormal_penis_morphology1.13901589
80MP0001216_abnormal_epidermal_layer1.12166927
81MP0010368_abnormal_lymphatic_system1.11895114
82MP0005584_abnormal_enzyme/coenzyme_acti1.11728642
83MP0006054_spinal_hemorrhage1.11632422
84MP0003329_amyloid_beta_deposits1.11495600
85MP0001845_abnormal_inflammatory_respons1.10709202
86MP0010307_abnormal_tumor_latency1.10467938
87MP0002254_reproductive_system_inflammat1.10045337
88MP0005310_abnormal_salivary_gland1.08877571
89MP0003303_peritoneal_inflammation1.08198863
90MP0001849_ear_inflammation1.06329229
91MP0000716_abnormal_immune_system1.05835761
92MP0003635_abnormal_synaptic_transmissio1.05162038
93MP0002078_abnormal_glucose_homeostasis1.04929895
94MP0005375_adipose_tissue_phenotype1.04111533
95MP0002166_altered_tumor_susceptibility1.04040473
96MP0002396_abnormal_hematopoietic_system1.03116809
97MP0008004_abnormal_stomach_pH1.02413132
98MP0004264_abnormal_extraembryonic_tissu1.02215648
99MP0002796_impaired_skin_barrier1.00439234
100MP0000465_gastrointestinal_hemorrhage0.99952176
101MP0000003_abnormal_adipose_tissue0.99062504
102MP0000490_abnormal_crypts_of0.98990541
103MP0008438_abnormal_cutaneous_collagen0.98614850
104MP0002909_abnormal_adrenal_gland0.97722292
105MP0003866_abnormal_defecation0.96983238
106MP0003075_altered_response_to0.96513567
107MP0002006_tumorigenesis0.96198319
108MP0001545_abnormal_hematopoietic_system0.95341231
109MP0005397_hematopoietic_system_phenotyp0.95341231
110MP0002429_abnormal_blood_cell0.93079004
111MP0005535_abnormal_body_temperature0.92546448
112MP0008872_abnormal_physiological_respon0.91259498
113MP0000249_abnormal_blood_vessel0.90737049
114MP0000767_abnormal_smooth_muscle0.89788055
115MP0002971_abnormal_brown_adipose0.89705356
116MP0008469_abnormal_protein_level0.88997527
117MP0005164_abnormal_response_to0.88696699
118MP0005621_abnormal_cell_physiology0.88566894
119MP0004510_myositis0.87821497
120MP0009931_abnormal_skin_appearance0.87744299
121MP0000703_abnormal_thymus_morphology0.87445158
122MP0005623_abnormal_meninges_morphology0.87348382
123MP0002722_abnormal_immune_system0.86443059
124MP0005166_decreased_susceptibility_to0.85410041
125MP0003950_abnormal_plasma_membrane0.84267849
126MP0009672_abnormal_birth_weight0.84160328
127MP0003279_aneurysm0.83624246
128MP0001915_intracranial_hemorrhage0.83551592
129MP0003195_calcinosis0.83367239
130MP0003795_abnormal_bone_structure0.83186839
131MP0008874_decreased_physiological_sensi0.82369582
132MP0001944_abnormal_pancreas_morphology0.82020500
133MP0005220_abnormal_exocrine_pancreas0.81979222
134MP0003183_abnormal_peptide_metabolism0.81849089
135MP0001958_emphysema0.80815537
136MP0005167_abnormal_blood-brain_barrier0.79817006
137MP0005390_skeleton_phenotype0.78685410
138MP0005165_increased_susceptibility_to0.78505646
139MP0002063_abnormal_learning/memory/cond0.78496423
140MP0000013_abnormal_adipose_tissue0.77584924
141MP0004087_abnormal_muscle_fiber0.77041969
142MP0002269_muscular_atrophy0.75831735
143MP0003283_abnormal_digestive_organ0.74882840
144MP0002928_abnormal_bile_duct0.74291734
145MP0001730_embryonic_growth_arrest0.73612807
146MP0003123_paternal_imprinting0.72630910
147MP0005334_abnormal_fat_pad0.72147319
148MP0001348_abnormal_lacrimal_gland0.71748444
149MP0003221_abnormal_cardiomyocyte_apopto0.71501677
150MP0005670_abnormal_white_adipose0.69806841
151MP0008770_decreased_survivor_rate0.68612394
152MP0003091_abnormal_cell_migration0.68408154
153MP0002089_abnormal_postnatal_growth/wei0.66784802
154MP0004858_abnormal_nervous_system0.65504267
155MP0000733_abnormal_muscle_development0.65464286
156MP0009643_abnormal_urine_homeostasis0.64408481
157MP0004808_abnormal_hematopoietic_stem0.64030337
158MP0002896_abnormal_bone_mineralization0.62986840
159MP0010630_abnormal_cardiac_muscle0.62899325
160MP0006036_abnormal_mitochondrial_physio0.62738007
161MP0002970_abnormal_white_adipose0.62439187
162MP0005330_cardiomyopathy0.61191437
163MP0002086_abnormal_extraembryonic_tissu0.60530201
164MP0004811_abnormal_neuron_physiology0.60410532
165MP0005464_abnormal_platelet_physiology0.60051230
166MP0003115_abnormal_respiratory_system0.59131018
167MP0004197_abnormal_fetal_growth/weight/0.58979015
168MP0009642_abnormal_blood_homeostasis0.57945836
169MP0005448_abnormal_energy_balance0.57634736
170MP0003633_abnormal_nervous_system0.57410437
171MP0005023_abnormal_wound_healing0.56955393
172MP0009763_increased_sensitivity_to0.54834194
173MP0005266_abnormal_metabolism0.54344379

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.97807054
2Abnormality of the lower motor neuron (HP:0002366)4.02262456
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.51129796
4Xanthomatosis (HP:0000991)3.47777131
5Abnormality of the Achilles tendon (HP:0005109)3.25214670
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.23925922
7Intrahepatic cholestasis (HP:0001406)3.16596918
8Hypobetalipoproteinemia (HP:0003563)3.12544960
9Ketosis (HP:0001946)3.01453732
10Flat acetabular roof (HP:0003180)2.99413895
11Achilles tendon contracture (HP:0001771)2.98181229
12Abnormality of the common coagulation pathway (HP:0010990)2.97446636
13Thin bony cortex (HP:0002753)2.88791541
14Protrusio acetabuli (HP:0003179)2.80367866
15Reticulocytosis (HP:0001923)2.79786946
16Spastic diplegia (HP:0001264)2.76156754
17Hyperammonemia (HP:0001987)2.72650505
18Eczematoid dermatitis (HP:0000976)2.72260493
19Dysmetric saccades (HP:0000641)2.65614227
20Lymphangioma (HP:0100764)2.61805000
21Obstructive sleep apnea (HP:0002870)2.60516725
22Hypoglycemic coma (HP:0001325)2.57939822
23Upper limb amyotrophy (HP:0009129)2.56234350
24Distal upper limb amyotrophy (HP:0007149)2.56234350
25Ketoacidosis (HP:0001993)2.54969554
26Interstitial pulmonary disease (HP:0006530)2.54275246
27Hyperlipoproteinemia (HP:0010980)2.50203781
28Cholelithiasis (HP:0001081)2.49585239
29Hypolipoproteinemia (HP:0010981)2.47022854
30Enlarged penis (HP:0000040)2.44539703
31Epidermoid cyst (HP:0200040)2.44487483
32Segmental peripheral demyelination/remyelination (HP:0003481)2.44243600
33Poikilocytosis (HP:0004447)2.39318106
34Complement deficiency (HP:0004431)2.38826894
35Hypoalphalipoproteinemia (HP:0003233)2.36454086
36Increased IgE level (HP:0003212)2.34452542
37Insomnia (HP:0100785)2.34232957
38Vertebral compression fractures (HP:0002953)2.34151832
39Asymmetry of the thorax (HP:0001555)2.32936785
40Abnormality of glycolipid metabolism (HP:0010969)2.29072012
41Abnormality of liposaccharide metabolism (HP:0010968)2.29072012
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.29072012
43Broad face (HP:0000283)2.29047897
44Acanthocytosis (HP:0001927)2.27351572
45Macroorchidism (HP:0000053)2.26535938
46Hand muscle atrophy (HP:0009130)2.25344397
47Abnormal gallbladder physiology (HP:0012438)2.24412404
48Cholecystitis (HP:0001082)2.24412404
49Global brain atrophy (HP:0002283)2.24249386
50Abnormal gallbladder morphology (HP:0012437)2.23125839
51Abnormality of the intrinsic pathway (HP:0010989)2.22325700
52Premature rupture of membranes (HP:0001788)2.22060403
53Turricephaly (HP:0000262)2.22030600
54Spondylolisthesis (HP:0003302)2.20990013
55Arterial tortuosity (HP:0005116)2.18653281
56Spinal cord lesions (HP:0100561)2.18361005
57Syringomyelia (HP:0003396)2.18361005
58Hepatocellular carcinoma (HP:0001402)2.18230349
59Skin nodule (HP:0200036)2.17526713
60Mitral valve prolapse (HP:0001634)2.16861516
61Dysostosis multiplex (HP:0000943)2.15158979
62Cutaneous melanoma (HP:0012056)2.14494256
63Abnormal social behavior (HP:0012433)2.11633962
64Impaired social interactions (HP:0000735)2.11633962
65Hyperacusis (HP:0010780)2.11516947
66Dilatation of the ascending aorta (HP:0005111)2.11513298
67Vascular tortuosity (HP:0004948)2.11356839
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10083450
69Heterotopia (HP:0002282)2.09902951
70Abnormality of macrophages (HP:0004311)2.09584443
71Fatigue (HP:0012378)2.09521034
72Polycythemia (HP:0001901)2.08743039
73Myokymia (HP:0002411)2.07382689
74Atrioventricular block (HP:0001678)2.05823469
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04792809
76Hyperbilirubinemia (HP:0002904)2.04268287
77Abnormality of oral frenula (HP:0000190)2.04099975
78Impaired vibration sensation in the lower limbs (HP:0002166)2.03523047
79Cellulitis (HP:0100658)2.02574500
80Gingivitis (HP:0000230)2.01899422
81Myocardial infarction (HP:0001658)2.01316858
82Cerebral aneurysm (HP:0004944)2.01070397
83Abnormality of the distal phalanx of the thumb (HP:0009617)2.00551216
84Genu recurvatum (HP:0002816)1.99543265
85Neurofibrillary tangles (HP:0002185)1.98962012
86Buphthalmos (HP:0000557)1.98552352
87Osteolytic defects of the phalanges of the hand (HP:0009771)1.97340266
88Osteolytic defects of the hand bones (HP:0009699)1.97340266
89Neonatal onset (HP:0003623)1.96933439
90Aneurysm (HP:0002617)1.94807865
91Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93660293
92Distal lower limb amyotrophy (HP:0008944)1.93588033
93Recurrent abscess formation (HP:0002722)1.92645367
94Hamartoma of the eye (HP:0010568)1.92425798
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92040749
96Disproportionate tall stature (HP:0001519)1.91510704
97Abnormality of the distal phalanges of the toes (HP:0010182)1.91310202
98Resting tremor (HP:0002322)1.91207951
99Hyperparathyroidism (HP:0000843)1.91015143
100Lower limb amyotrophy (HP:0007210)1.91004165
101Pustule (HP:0200039)1.90882404
102Myoglobinuria (HP:0002913)1.90370926
103Abnormality of sulfur amino acid metabolism (HP:0004339)1.89145664
104Difficulty climbing stairs (HP:0003551)1.88979586
105Poor eye contact (HP:0000817)1.88784582
106Cerebral inclusion bodies (HP:0100314)1.88018093
107Abnormality of carpal bone ossification (HP:0006257)1.87688890
108Bundle branch block (HP:0011710)1.87568234
109Sensorimotor neuropathy (HP:0007141)1.87044078
110Abnormal cartilage morphology (HP:0002763)1.86710098
111Long toe (HP:0010511)1.86630757
112Autoimmune thrombocytopenia (HP:0001973)1.86232956
113Atrophic scars (HP:0001075)1.85926461
114Prolonged partial thromboplastin time (HP:0003645)1.85497239
115Spinal cord compression (HP:0002176)1.84979962
116Subacute progressive viral hepatitis (HP:0006572)1.84696213
117Spontaneous hematomas (HP:0007420)1.84694595
118Wormian bones (HP:0002645)1.84603269
119Status epilepticus (HP:0002133)1.84507029
120Renovascular hypertension (HP:0100817)1.84447688
121Conjunctival hamartoma (HP:0100780)1.83773786
122Spontaneous abortion (HP:0005268)1.83696873
123Gout (HP:0001997)1.83601698
124Angiofibromas (HP:0010615)1.83130528
125Adenoma sebaceum (HP:0009720)1.83130528
126Hemorrhage of the eye (HP:0011885)1.82851924
127Abnormal ossification of hand bones (HP:0005921)1.82101836
128Malnutrition (HP:0004395)1.81915454
129Papilledema (HP:0001085)1.81857494
130Polygenic inheritance (HP:0010982)1.81451229
131Coarse hair (HP:0002208)1.80647557
132Urinary glycosaminoglycan excretion (HP:0003541)1.80510767
133Mucopolysacchariduria (HP:0008155)1.80510767
134Aortic aneurysm (HP:0004942)1.80396927
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79864765
136Abnormality of polysaccharide metabolism (HP:0011012)1.79864765
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79864765
138Visual hallucinations (HP:0002367)1.79679553
139Fibroma (HP:0010614)1.79529842
140Onion bulb formation (HP:0003383)1.78800962
141Thick nail (HP:0001805)1.78788168
142Slow saccadic eye movements (HP:0000514)1.78620659
143Cervical subluxation (HP:0003308)1.78417017
144Hypercholesterolemia (HP:0003124)1.78057586
145Ankyloglossia (HP:0010296)1.78016107
146Fragile skin (HP:0001030)1.77588287
147Distal lower limb muscle weakness (HP:0009053)1.77337707
148Autoimmune hemolytic anemia (HP:0001890)1.77224978
149Increased cerebral lipofuscin (HP:0011813)1.75965729
150Loss of speech (HP:0002371)1.75906090
151Emphysema (HP:0002097)1.75798958
152Coxa vara (HP:0002812)1.75736362
153Mitral stenosis (HP:0001718)1.75510438
154Recurrent gram-negative bacterial infections (HP:0005420)1.75190676
155Abnormality of complement system (HP:0005339)1.74779139
156Striae distensae (HP:0001065)1.74395189
157Ulnar bowing (HP:0003031)1.73688830
158Urinary urgency (HP:0000012)1.71879754
159Abnormality of serine family amino acid metabolism (HP:0010894)1.71413083
160Abnormality of glycine metabolism (HP:0010895)1.71413083
161Insidious onset (HP:0003587)1.71003898
162Termporal pattern (HP:0011008)1.71003898
163Periodontitis (HP:0000704)1.70441752
164Abnormality of the fingertips (HP:0001211)1.70272771
165Abnormality of fatty-acid metabolism (HP:0004359)1.70194662
166Bone pain (HP:0002653)1.70111943
167Hyperglycinemia (HP:0002154)1.69626841
168Pointed chin (HP:0000307)1.69282724
169Recurrent viral infections (HP:0004429)1.68074115
170Cupped ribs (HP:0000887)1.66055318
171Aortic dissection (HP:0002647)1.63739138
172Milia (HP:0001056)1.63575788
173Abnormal delayed hypersensitivity skin test (HP:0002963)1.63243289
174Dislocated radial head (HP:0003083)1.62189787
175Vasculitis (HP:0002633)1.62135707
176Blue sclerae (HP:0000592)1.61717133
177Persistence of primary teeth (HP:0006335)1.59036377
178Myositis (HP:0100614)1.58364169
179Short nail (HP:0001799)1.57532168
180Orchitis (HP:0100796)1.56489639
181Mitral regurgitation (HP:0001653)1.55705194
182Elevated erythrocyte sedimentation rate (HP:0003565)1.52807148
183Gastrointestinal infarctions (HP:0005244)1.52529642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD45.84689925
2TRIB34.93850737
3PRPF4B4.54037772
4PKN23.93308874
5IRAK33.37820359
6EEF2K2.59872459
7MAP3K132.48985592
8KSR22.38586405
9RIPK12.26383107
10MAP3K142.22986557
11PRKD31.98021074
12DAPK21.91570646
13MAP4K11.88796823
14SCYL21.88472172
15SMG11.86806506
16MAP3K91.80956551
17MST1R1.77272213
18TAOK11.66863766
19NEK91.64079766
20CAMKK11.63111847
21MAP3K101.58869751
22ZAP701.57977292
23MAP3K21.57735455
24ERN11.55664742
25FRK1.54882125
26RET1.52031216
27ALK1.51091700
28LATS21.50864314
29MAP3K71.49107625
30TAOK21.45464169
31MAP3K31.45462908
32EPHA21.45102297
33IRAK21.41791757
34EPHB11.41237229
35MAP2K41.41232146
36PAK61.41229336
37MAP3K41.38424214
38TBK11.37100157
39IRAK11.36874166
40SIK31.36573615
41EPHA41.36215353
42LATS11.33981530
43NEK11.33026751
44NTRK31.32971567
45PTK61.32910217
46PDGFRA1.32104944
47IRAK41.30991684
48RIPK41.30189095
49TYK21.28632193
50SIK11.27721037
51TTN1.25026186
52FLT31.11805862
53BMPR21.08175383
54CDK91.03738625
55BMX1.00566878
56JAK11.00456514
57CDK120.91572888
58CSK0.90884901
59EPHA30.90504304
60IKBKB0.90388020
61PTK2B0.90100343
62KSR10.88013930
63STK380.86336450
64BCKDK0.86282475
65PDK30.86083352
66PDK40.86083352
67FES0.85212660
68TGFBR20.85186655
69IKBKE0.85056796
70CDC70.81225610
71CDC42BPA0.80523700
72SGK30.79854051
73MAP3K10.79540122
74FGFR20.79147182
75NTRK10.78337941
76STK240.77851152
77MINK10.77695222
78TAOK30.76573515
79NME20.75050556
80FGFR40.74709827
81PRKD20.74322878
82MAP2K30.71901282
83MAPK70.71558914
84HCK0.70820751
85FGFR30.70778839
86MTOR0.70680406
87RPS6KL10.70433362
88RPS6KC10.70433362
89DAPK10.69139823
90TYRO30.69075676
91PAK40.68011704
92CHUK0.66571529
93PRKCH0.66537186
94CDK60.64864762
95PDK10.63797875
96JAK20.63421354
97MAP3K110.61727799
98MAP2K10.61497908
99DDR20.61148827
100CAMK1D0.60865379
101MET0.60544480
102NEK20.59644009
103MAP3K60.59578506
104MAPK110.58929559
105PAK20.58920812
106STK110.58800605
107LMTK20.58300534
108LRRK20.57961596
109PDPK10.57687785
110TRPM70.57011732
111TXK0.55575935
112CDK40.52437397
113SIK20.52169671
114RPS6KA60.51233515
115MAPK120.50353158
116RAF10.49856889
117BLK0.49661375
118CAMK1G0.49557593
119STK100.49239178
120TIE10.47396905
121MAPK40.46840498
122CDK50.46549643
123PTK20.45335747
124CLK10.44757565
125MAP3K80.43881924
126PRKCZ0.42382892
127CAMK40.40912443
128MOS0.39697309
129GRK60.39615109
130RPS6KB10.38649723
131ICK0.38335801
132ILK0.38210751
133STK30.37878433
134PDGFRB0.37026259
135RPS6KA40.34659365
136RPS6KA30.31212396
137HIPK20.30309339
138JAK30.30097039
139MARK20.29708144
140PRKAA20.29427542
141MAP3K50.28813759
142SGK10.28640022
143MELK0.28274774
144MAPK100.27735391
145RPS6KA20.25720958

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.29562144
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.04822177
3Nitrogen metabolism_Homo sapiens_hsa009103.85379888
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.89561898
5Arginine biosynthesis_Homo sapiens_hsa002202.68669684
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27973633
7Fatty acid degradation_Homo sapiens_hsa000712.07515992
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.00306063
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90939777
10Osteoclast differentiation_Homo sapiens_hsa043801.89067627
11Other glycan degradation_Homo sapiens_hsa005111.88681664
12Leishmaniasis_Homo sapiens_hsa051401.80900177
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80019324
14B cell receptor signaling pathway_Homo sapiens_hsa046621.79163906
15TNF signaling pathway_Homo sapiens_hsa046681.75279132
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68386058
17PPAR signaling pathway_Homo sapiens_hsa033201.61782982
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61025942
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.59717781
20Bile secretion_Homo sapiens_hsa049761.59496740
21Propanoate metabolism_Homo sapiens_hsa006401.58202020
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56887666
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55929735
24Renal cell carcinoma_Homo sapiens_hsa052111.53793725
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.52737391
26Tryptophan metabolism_Homo sapiens_hsa003801.49099070
27T cell receptor signaling pathway_Homo sapiens_hsa046601.45989947
28Toxoplasmosis_Homo sapiens_hsa051451.43220021
29Hepatitis B_Homo sapiens_hsa051611.42532963
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41626703
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38957905
32Influenza A_Homo sapiens_hsa051641.38671218
33Fatty acid metabolism_Homo sapiens_hsa012121.37757919
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37056045
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36231575
36Butanoate metabolism_Homo sapiens_hsa006501.36190996
37Complement and coagulation cascades_Homo sapiens_hsa046101.31154944
38Glioma_Homo sapiens_hsa052141.31037628
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30484966
40Selenocompound metabolism_Homo sapiens_hsa004501.29015839
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29009409
42Biosynthesis of amino acids_Homo sapiens_hsa012301.28837717
43Pertussis_Homo sapiens_hsa051331.26878545
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.26739436
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25508364
46Hepatitis C_Homo sapiens_hsa051601.25410356
47Carbon metabolism_Homo sapiens_hsa012001.24743714
48Glucagon signaling pathway_Homo sapiens_hsa049221.24589673
49Measles_Homo sapiens_hsa051621.24001963
50Malaria_Homo sapiens_hsa051441.19757135
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18409227
52Tuberculosis_Homo sapiens_hsa051521.16796481
53Long-term potentiation_Homo sapiens_hsa047201.16676985
54Olfactory transduction_Homo sapiens_hsa047401.16167859
55Insulin resistance_Homo sapiens_hsa049311.15947071
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.15486878
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.14883451
58Small cell lung cancer_Homo sapiens_hsa052221.14518780
59mTOR signaling pathway_Homo sapiens_hsa041501.12775207
60Apoptosis_Homo sapiens_hsa042101.11571044
61Pyruvate metabolism_Homo sapiens_hsa006201.11530401
62Legionellosis_Homo sapiens_hsa051341.11163263
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10242752
64Amoebiasis_Homo sapiens_hsa051461.10092281
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09295878
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.08776367
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05806320
68Central carbon metabolism in cancer_Homo sapiens_hsa052301.04086624
69Leukocyte transendothelial migration_Homo sapiens_hsa046701.01729333
70Shigellosis_Homo sapiens_hsa051311.00799370
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00459031
72Prostate cancer_Homo sapiens_hsa052151.00430990
73Jak-STAT signaling pathway_Homo sapiens_hsa046301.00218637
74Lysine degradation_Homo sapiens_hsa003101.00172439
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99616035
76Insulin signaling pathway_Homo sapiens_hsa049100.98715375
77Non-small cell lung cancer_Homo sapiens_hsa052230.96320675
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95580764
79beta-Alanine metabolism_Homo sapiens_hsa004100.95227814
80Salmonella infection_Homo sapiens_hsa051320.95063455
81Allograft rejection_Homo sapiens_hsa053300.94338800
82Type II diabetes mellitus_Homo sapiens_hsa049300.93699281
83Staphylococcus aureus infection_Homo sapiens_hsa051500.93318487
84Viral myocarditis_Homo sapiens_hsa054160.91903681
85Graft-versus-host disease_Homo sapiens_hsa053320.90580599
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90124626
87Chemokine signaling pathway_Homo sapiens_hsa040620.89095775
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89059309
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88562756
90AMPK signaling pathway_Homo sapiens_hsa041520.88296807
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.88261694
92Proteoglycans in cancer_Homo sapiens_hsa052050.87479066
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.86981199
94Herpes simplex infection_Homo sapiens_hsa051680.85829687
95Notch signaling pathway_Homo sapiens_hsa043300.85787844
96Chemical carcinogenesis_Homo sapiens_hsa052040.85459271
97Focal adhesion_Homo sapiens_hsa045100.85160466
98Chronic myeloid leukemia_Homo sapiens_hsa052200.84951296
99MicroRNAs in cancer_Homo sapiens_hsa052060.84445493
100Choline metabolism in cancer_Homo sapiens_hsa052310.83876674
101Colorectal cancer_Homo sapiens_hsa052100.83372820
102Lysosome_Homo sapiens_hsa041420.82233634
103Inositol phosphate metabolism_Homo sapiens_hsa005620.81685260
104HTLV-I infection_Homo sapiens_hsa051660.81493360
105Viral carcinogenesis_Homo sapiens_hsa052030.81219049
106Autoimmune thyroid disease_Homo sapiens_hsa053200.80251340
107Estrogen signaling pathway_Homo sapiens_hsa049150.80140864
108African trypanosomiasis_Homo sapiens_hsa051430.78142902
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.77709070
110Amphetamine addiction_Homo sapiens_hsa050310.77606166
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.77603679
112Starch and sucrose metabolism_Homo sapiens_hsa005000.77519255
113Fatty acid biosynthesis_Homo sapiens_hsa000610.76943755
114Platelet activation_Homo sapiens_hsa046110.76485194
115GnRH signaling pathway_Homo sapiens_hsa049120.75630623
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75009651
117Hematopoietic cell lineage_Homo sapiens_hsa046400.73144081
118VEGF signaling pathway_Homo sapiens_hsa043700.72034279
119Phenylalanine metabolism_Homo sapiens_hsa003600.71867762
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71785726
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70244655
122MAPK signaling pathway_Homo sapiens_hsa040100.70033462
123HIF-1 signaling pathway_Homo sapiens_hsa040660.66527934
124One carbon pool by folate_Homo sapiens_hsa006700.65366663
125Bladder cancer_Homo sapiens_hsa052190.65055509
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.64479198
127Endocytosis_Homo sapiens_hsa041440.63705810
128Dorso-ventral axis formation_Homo sapiens_hsa043200.62934511
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62910589
130Endometrial cancer_Homo sapiens_hsa052130.62868382
131Dopaminergic synapse_Homo sapiens_hsa047280.61312519
132Rheumatoid arthritis_Homo sapiens_hsa053230.61257933
133Peroxisome_Homo sapiens_hsa041460.60598950
134Fat digestion and absorption_Homo sapiens_hsa049750.59915137
135Gastric acid secretion_Homo sapiens_hsa049710.59901893
136Oxytocin signaling pathway_Homo sapiens_hsa049210.56545933
137Insulin secretion_Homo sapiens_hsa049110.54593042
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54271771
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53233483
140Thyroid cancer_Homo sapiens_hsa052160.53012680
141Circadian entrainment_Homo sapiens_hsa047130.52903813
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52877854
143ABC transporters_Homo sapiens_hsa020100.52551765
144Adherens junction_Homo sapiens_hsa045200.52448838
145Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51185957
146Prolactin signaling pathway_Homo sapiens_hsa049170.51139600
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50930737
148Cholinergic synapse_Homo sapiens_hsa047250.49699332
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49607077
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47190733
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46884651
152Glycerolipid metabolism_Homo sapiens_hsa005610.46475190
153Sulfur relay system_Homo sapiens_hsa041220.45925724
154Acute myeloid leukemia_Homo sapiens_hsa052210.45893688
155ErbB signaling pathway_Homo sapiens_hsa040120.45522187
156Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43657394
157Salivary secretion_Homo sapiens_hsa049700.42651260
158Renin secretion_Homo sapiens_hsa049240.41371182
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40356013
160Pancreatic cancer_Homo sapiens_hsa052120.40241310
161Synaptic vesicle cycle_Homo sapiens_hsa047210.39826463
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39408271
163Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39066178
164Pentose phosphate pathway_Homo sapiens_hsa000300.37786242
165Thyroid hormone synthesis_Homo sapiens_hsa049180.35515141
166Prion diseases_Homo sapiens_hsa050200.35278607
167FoxO signaling pathway_Homo sapiens_hsa040680.34372153
168Gap junction_Homo sapiens_hsa045400.34109699
169GABAergic synapse_Homo sapiens_hsa047270.32346347
170Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32042559

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