JRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.86809075
2transcription from mitochondrial promoter (GO:0006390)7.27563824
3replication fork processing (GO:0031297)6.35585339
4proline metabolic process (GO:0006560)6.25268367
5embryonic process involved in female pregnancy (GO:0060136)6.21497006
6establishment of apical/basal cell polarity (GO:0035089)5.78878878
7poly(A)+ mRNA export from nucleus (GO:0016973)5.61116038
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.55083511
9positive regulation of protein homooligomerization (GO:0032464)5.46819210
10oxidative demethylation (GO:0070989)5.15148711
11DNA deamination (GO:0045006)5.06760494
12establishment or maintenance of monopolar cell polarity (GO:0061339)5.05502301
13establishment of monopolar cell polarity (GO:0061162)5.05502301
14DNA strand renaturation (GO:0000733)4.96283965
15spliceosomal tri-snRNP complex assembly (GO:0000244)4.93815451
16somatic hypermutation of immunoglobulin genes (GO:0016446)4.91713007
17somatic diversification of immune receptors via somatic mutation (GO:0002566)4.91713007
18regulation of integrin activation (GO:0033623)4.90772142
19regulation of protein homooligomerization (GO:0032462)4.89479619
20histone H4-K12 acetylation (GO:0043983)4.62278535
21mitotic G1 DNA damage checkpoint (GO:0031571)4.56239922
22nuclear pore complex assembly (GO:0051292)4.47499020
23mitochondrial DNA metabolic process (GO:0032042)4.45003149
24positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.27355701
25mRNA cleavage (GO:0006379)4.22398135
26viral mRNA export from host cell nucleus (GO:0046784)4.21295651
27negative regulation of JAK-STAT cascade (GO:0046426)4.19715306
28mitotic chromosome condensation (GO:0007076)4.13744014
29DNA unwinding involved in DNA replication (GO:0006268)4.10911069
30regulation of translational fidelity (GO:0006450)4.10497996
31embryonic placenta development (GO:0001892)4.08056187
32base-excision repair (GO:0006284)4.05815106
33regulation of RNA export from nucleus (GO:0046831)4.01595515
34histone H4-K8 acetylation (GO:0043982)4.00219601
35histone H4-K5 acetylation (GO:0043981)4.00219601
36regulation of gene silencing by RNA (GO:0060966)3.97780351
37regulation of posttranscriptional gene silencing (GO:0060147)3.97780351
38regulation of gene silencing by miRNA (GO:0060964)3.97780351
39histone H3-K4 trimethylation (GO:0080182)3.91609477
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.91435597
41nuclear pore organization (GO:0006999)3.91210530
42heterochromatin organization (GO:0070828)3.89419320
43histone H3-K36 demethylation (GO:0070544)3.88985230
44mitotic G1/S transition checkpoint (GO:0044819)3.88719498
45DNA replication initiation (GO:0006270)3.87169986
46negative regulation of cell cycle arrest (GO:0071157)3.85616778
47positive regulation of protein oligomerization (GO:0032461)3.80239527
48G1 DNA damage checkpoint (GO:0044783)3.79898537
49non-recombinational repair (GO:0000726)3.76100703
50double-strand break repair via nonhomologous end joining (GO:0006303)3.76100703
51mannose metabolic process (GO:0006013)3.72802200
52regulation of NFAT protein import into nucleus (GO:0051532)3.72684813
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.67801646
54embryonic camera-type eye development (GO:0031076)3.67717525
55regulation of histone H3-K27 methylation (GO:0061085)3.67578775
56DNA ligation (GO:0006266)3.66860125
57DNA duplex unwinding (GO:0032508)3.64878036
58heart field specification (GO:0003128)3.64528063
59secondary heart field specification (GO:0003139)3.64528063
60response to UV-C (GO:0010225)3.62878172
61peptidyl-lysine dimethylation (GO:0018027)3.61558847
62dosage compensation (GO:0007549)3.59342226
63termination of RNA polymerase II transcription (GO:0006369)3.57637732
64negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.56415686
65glucocorticoid receptor signaling pathway (GO:0042921)3.53963591
66regulation of cAMP-dependent protein kinase activity (GO:2000479)3.52912864
67DNA topological change (GO:0006265)3.49055203
68protein-DNA complex disassembly (GO:0032986)3.48778011
69nucleosome disassembly (GO:0006337)3.48778011
70telomere maintenance via semi-conservative replication (GO:0032201)3.47733264
71regulation of protein oligomerization (GO:0032459)3.47597397
72DNA geometric change (GO:0032392)3.46481348
73cellular response to ATP (GO:0071318)3.45836933
74mitotic sister chromatid segregation (GO:0000070)3.41627484
75negative regulation of mRNA processing (GO:0050686)3.41338642
76DNA double-strand break processing (GO:0000729)3.40574900
77TOR signaling (GO:0031929)3.40500877
78negative regulation of protein oligomerization (GO:0032460)3.40121383
79base-excision repair, AP site formation (GO:0006285)3.39520913
80convergent extension (GO:0060026)3.39261321
81intracellular estrogen receptor signaling pathway (GO:0030520)3.39147026
82stress granule assembly (GO:0034063)3.37831568
83mitotic sister chromatid cohesion (GO:0007064)3.37056284
84face development (GO:0060324)3.36924848
85histone H3-K4 methylation (GO:0051568)3.34762718
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.32809551
87regulation of chromatin binding (GO:0035561)3.30370840
88sister chromatid segregation (GO:0000819)3.30243776
89alkaloid metabolic process (GO:0009820)3.29248048
90histone lysine methylation (GO:0034968)3.28428562
91regulation of DNA damage checkpoint (GO:2000001)3.28014920
92regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.26802024
93pre-miRNA processing (GO:0031054)3.25861718
94glutamine family amino acid biosynthetic process (GO:0009084)3.25684767
95glandular epithelial cell development (GO:0002068)3.25616993
96cytoplasmic mRNA processing body assembly (GO:0033962)3.25550838
97anatomical structure regression (GO:0060033)3.24963067
98regulation of fatty acid beta-oxidation (GO:0031998)3.24115900
99negative regulation of Ras GTPase activity (GO:0034261)3.22146925
100activation of Rac GTPase activity (GO:0032863)3.20349556
101snRNA metabolic process (GO:0016073)3.20167175
102meiotic chromosome segregation (GO:0045132)3.19819441
103single strand break repair (GO:0000012)3.19404724
104negative regulation of histone methylation (GO:0031061)3.18646943
105insulin-like growth factor receptor signaling pathway (GO:0048009)3.18574526
106positive regulation of mitotic sister chromatid separation (GO:1901970)3.18211416
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18211416
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18211416
109regulation of histone H3-K4 methylation (GO:0051569)3.16791169
110focal adhesion assembly (GO:0048041)3.16612850
111cell-substrate adherens junction assembly (GO:0007045)3.16612850
112histone H3-K9 methylation (GO:0051567)3.16497893
113mRNA polyadenylation (GO:0006378)3.15008729
114peptidyl-lysine methylation (GO:0018022)3.13428761
115labyrinthine layer development (GO:0060711)3.12968797
116apoptotic process involved in morphogenesis (GO:0060561)3.12962400
117positive regulation of CREB transcription factor activity (GO:0032793)3.11593012
118negative regulation of gene expression, epigenetic (GO:0045814)3.10877571
119negative regulation of fatty acid biosynthetic process (GO:0045717)3.10167293
120DNA integration (GO:0015074)3.10062244
121positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09265949
122adherens junction assembly (GO:0034333)3.06940396
123formation of translation preinitiation complex (GO:0001731)3.06183310
124pore complex assembly (GO:0046931)3.06141760
125negative regulation of RNA splicing (GO:0033119)3.06019386
126cellular response to zinc ion (GO:0071294)3.05343219
127oxygen transport (GO:0015671)3.04306220
128mitochondrial RNA metabolic process (GO:0000959)3.03745810
129histone methylation (GO:0016571)3.02823465
130trophectodermal cell differentiation (GO:0001829)3.02542034
131regulation of double-strand break repair (GO:2000779)3.00498214
132regulation of double-strand break repair via homologous recombination (GO:0010569)2.99089636
133positive regulation by host of viral transcription (GO:0043923)2.96933452
134regulation of nucleobase-containing compound transport (GO:0032239)2.96670686
135monoubiquitinated protein deubiquitination (GO:0035520)2.96564027
136nucleotide-excision repair, DNA damage removal (GO:0000718)2.95804510
137DNA excision (GO:0044349)2.95804510
138DNA strand elongation (GO:0022616)2.95740039
139nodal signaling pathway (GO:0038092)2.95070740
140chromatin silencing (GO:0006342)2.94673132
141DNA strand elongation involved in DNA replication (GO:0006271)2.93672043
142glial cell migration (GO:0008347)2.92644548
143regulation of hippo signaling (GO:0035330)2.91835983
144mRNA export from nucleus (GO:0006406)2.91612733
145pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91258008
146histone H3-K9 modification (GO:0061647)2.91004326
147DNA conformation change (GO:0071103)2.90897124
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90789097
149establishment of mitotic spindle localization (GO:0040001)2.90605707
150negative regulation of cell cycle G2/M phase transition (GO:1902750)2.90397832
151peptidyl-lysine trimethylation (GO:0018023)2.89833272
152corticosteroid receptor signaling pathway (GO:0031958)2.89650402
153RNA polyadenylation (GO:0043631)2.89587790
154DNA synthesis involved in DNA repair (GO:0000731)2.88491183
155histone deubiquitination (GO:0016578)2.87432459
156negative regulation of appetite (GO:0032099)2.86810074
157negative regulation of response to food (GO:0032096)2.86810074
158positive regulation of histone deacetylation (GO:0031065)2.86502415
159embryonic eye morphogenesis (GO:0048048)2.84338359
160regulation of histone methylation (GO:0031060)2.83016727
161regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81476527
162embryonic body morphogenesis (GO:0010172)2.80984554
163negative regulation of DNA repair (GO:0045738)2.79016574
164negative regulation of cell size (GO:0045792)2.78808828
165establishment of spindle localization (GO:0051293)2.78362183
166snRNA transcription (GO:0009301)2.77365817
167snRNA processing (GO:0016180)2.72909597
168paraxial mesoderm development (GO:0048339)2.71805059
169folic acid metabolic process (GO:0046655)2.71129823
170embryonic camera-type eye morphogenesis (GO:0048596)2.69603858
171positive regulation of gene expression, epigenetic (GO:0045815)2.69197206
172negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.68290852
173histone H4-K16 acetylation (GO:0043984)2.66232178
174establishment of spindle orientation (GO:0051294)2.65369966
175atrioventricular valve morphogenesis (GO:0003181)2.64264385
176RNA stabilization (GO:0043489)2.63221023
177mRNA stabilization (GO:0048255)2.63221023
178negative regulation of viral release from host cell (GO:1902187)2.58901341
179positive regulation of protein deacetylation (GO:0090312)2.58383685
180establishment of mitotic spindle orientation (GO:0000132)2.58216097
181chromatin assembly (GO:0031497)2.56052456
182histone acetylation (GO:0016573)2.55854649
183chromosome condensation (GO:0030261)2.55759563
184apoptotic process involved in development (GO:1902742)2.51389905
185inner cell mass cell proliferation (GO:0001833)2.51321391
186histone lysine demethylation (GO:0070076)2.50916035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.45543655
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.39163791
3E2F7_22180533_ChIP-Seq_HELA_Human3.25106095
4* MYC_18555785_ChIP-Seq_MESCs_Mouse2.67760775
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57003410
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.51679010
7SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.49807021
8VDR_21846776_ChIP-Seq_THP-1_Human2.45792479
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.40404552
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.40404552
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.40404552
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36593278
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31495590
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30167397
15DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.27827343
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.18200678
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.13753295
18NANOG_21062744_ChIP-ChIP_HESCs_Human2.12831674
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11112385
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.11078641
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.10214376
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09332775
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.08476395
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03924164
25ZNF263_19887448_ChIP-Seq_K562_Human2.01690317
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.95068315
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94325586
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92415909
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92268181
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90385843
31MYC_22102868_ChIP-Seq_BL_Human1.87546808
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.87105060
33* LXR_22292898_ChIP-Seq_THP-1_Human1.85731860
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.84101777
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.79579824
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.79470571
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78856841
38PU.1_20513432_ChIP-Seq_Bcells_Mouse1.73734265
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.73141430
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72846659
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72202675
42* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71987181
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70054723
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.69900976
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69261777
46CREB1_26743006_Chip-Seq_LNCaP_Human1.68599364
47* SMC4_20622854_ChIP-Seq_HELA_Human1.66028746
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64230190
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.60987618
50MAF_26560356_Chip-Seq_TH2_Human1.59945877
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.58883986
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55804275
53CIITA_25753668_ChIP-Seq_RAJI_Human1.53486162
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52910249
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52148517
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51074123
57KDM2B_26808549_Chip-Seq_DND41_Human1.50067318
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48223203
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.47585967
60CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46636493
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.46042067
62* ERG_21242973_ChIP-ChIP_JURKAT_Human1.45124411
63* TET1_21451524_ChIP-Seq_MESCs_Mouse1.44697860
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44005213
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42639289
66* P68_20966046_ChIP-Seq_HELA_Human1.41785988
67MAF_26560356_Chip-Seq_TH1_Human1.41166619
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41107388
69VDR_24763502_ChIP-Seq_THP-1_Human1.41024606
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40294322
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38201486
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.36560576
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.36239920
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35933559
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34777760
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34464285
77* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33933936
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33600947
79TP53_22127205_ChIP-Seq_IMR90_Human1.32766893
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31609412
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30679954
82* GABP_19822575_ChIP-Seq_HepG2_Human1.30058651
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29741476
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29708648
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29643060
86* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28455980
87SCL_19346495_ChIP-Seq_HPC-7_Human1.28254459
88UTX_26944678_Chip-Seq_JUKART_Human1.27948748
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27453496
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27407162
91CHD1_26751641_Chip-Seq_LNCaP_Human1.27067488
92SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26957013
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26438904
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23755121
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22728736
96RACK7_27058665_Chip-Seq_MCF-7_Human1.22349654
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21785334
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21305055
99KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20915898
100NCOR1_26117541_ChIP-Seq_K562_Human1.20763595
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20482405
102* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19964591
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19613714
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.17958833
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.17935566
106XRN2_22483619_ChIP-Seq_HELA_Human1.17891388
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16604843
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16177701
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15814903
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14345242
111SPI1_26923725_Chip-Seq_HPCs_Mouse1.14305370
112CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13563388
113ETS1_21867929_ChIP-Seq_TH2_Mouse1.13290865
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13259151
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12356530
116* YY1_22570637_ChIP-Seq_MALME-3M_Human1.11875029
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11579345
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10575793
119TCF7_22412390_ChIP-Seq_EML_Mouse1.09884026
120CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09669140
121* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09454145
122E2F1_21310950_ChIP-Seq_MCF-7_Human1.07341047
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06697977
124RARB_24833708_ChIP-Seq_LIVER_Mouse1.05779003
125HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05386958
126UBF1/2_26484160_Chip-Seq_HMECs_Human1.05317997
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04662114
128STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04130184
129PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03441816
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.03078417
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02662265
132E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02631766
133CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02552778
134NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02500490
135NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02287298
136* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02249406
137RARA_24833708_ChIP-Seq_LIVER_Mouse1.02183080
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01820647
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01684645
140TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01570854
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01352412
142TTF2_22483619_ChIP-Seq_HELA_Human0.99283927
143KDM2B_26808549_Chip-Seq_K562_Human0.99171771
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99073242
145EGR1_19374776_ChIP-ChIP_THP-1_Human0.98765043
146KDM5A_27292631_Chip-Seq_BREAST_Human0.98684277
147* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98670450
148TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94675168
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92805600
150ATF3_27146783_Chip-Seq_COLON_Human0.92330361
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91360156
152MITF_21258399_ChIP-Seq_MELANOMA_Human0.90870257
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90843210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication7.48886635
2MP0004233_abnormal_muscle_weight3.82791264
3MP0005083_abnormal_biliary_tract3.65038289
4MP0003705_abnormal_hypodermis_morpholog3.49948516
5MP0005171_absent_coat_pigmentation3.42972866
6MP0010030_abnormal_orbit_morphology3.40964279
7MP0009278_abnormal_bone_marrow3.06559227
8MP0002009_preneoplasia2.88328654
9MP0006292_abnormal_olfactory_placode2.70843714
10MP0003119_abnormal_digestive_system2.62505293
11MP0002396_abnormal_hematopoietic_system2.57382680
12MP0006072_abnormal_retinal_apoptosis2.52698841
13MP0010094_abnormal_chromosome_stability2.41474196
14MP0003283_abnormal_digestive_organ2.41430840
15MP0008058_abnormal_DNA_repair2.18485330
16MP0000015_abnormal_ear_pigmentation2.11098775
17MP0008877_abnormal_DNA_methylation2.03146545
18MP0003693_abnormal_embryo_hatching1.97961409
19MP0004381_abnormal_hair_follicle1.96255821
20MP0003890_abnormal_embryonic-extraembry1.93935389
21MP0004808_abnormal_hematopoietic_stem1.88404339
22MP0001849_ear_inflammation1.88211095
23MP0004133_heterotaxia1.86788423
24MP0004957_abnormal_blastocyst_morpholog1.86280280
25MP0010352_gastrointestinal_tract_polyps1.82710662
26MP0002084_abnormal_developmental_patter1.78535557
27MP0002282_abnormal_trachea_morphology1.78168381
28MP0001293_anophthalmia1.78113592
29MP0005174_abnormal_tail_pigmentation1.77327073
30MP0004185_abnormal_adipocyte_glucose1.77285503
31MP0003111_abnormal_nucleus_morphology1.76437830
32MP0002269_muscular_atrophy1.74380421
33MP0002653_abnormal_ependyma_morphology1.69103900
34MP0002249_abnormal_larynx_morphology1.68199609
35MP0008995_early_reproductive_senescence1.63164640
36MP0005623_abnormal_meninges_morphology1.62929726
37MP0005076_abnormal_cell_differentiation1.61161227
38MP0000537_abnormal_urethra_morphology1.58867164
39MP0005409_darkened_coat_color1.58782332
40MP0005451_abnormal_body_composition1.53278480
41MP0005410_abnormal_fertilization1.52778173
42MP0001697_abnormal_embryo_size1.51551964
43MP0000003_abnormal_adipose_tissue1.50314784
44MP0003077_abnormal_cell_cycle1.48666424
45MP0004197_abnormal_fetal_growth/weight/1.47018212
46MP0002085_abnormal_embryonic_tissue1.45427105
47MP0000470_abnormal_stomach_morphology1.43299275
48MP0001545_abnormal_hematopoietic_system1.40284275
49MP0005397_hematopoietic_system_phenotyp1.40284275
50MP0003315_abnormal_perineum_morphology1.40128577
51MP0000428_abnormal_craniofacial_morphol1.39207672
52MP0008932_abnormal_embryonic_tissue1.38100969
53MP0002086_abnormal_extraembryonic_tissu1.37644307
54MP0003786_premature_aging1.37029249
55MP0002108_abnormal_muscle_morphology1.33159739
56MP0000733_abnormal_muscle_development1.32251134
57MP0003942_abnormal_urinary_system1.32121936
58MP0003763_abnormal_thymus_physiology1.28871895
59MP0001672_abnormal_embryogenesis/_devel1.25415433
60MP0005380_embryogenesis_phenotype1.25415433
61MP0001661_extended_life_span1.24287500
62MP0009672_abnormal_birth_weight1.21120548
63MP0003937_abnormal_limbs/digits/tail_de1.20872682
64MP0008961_abnormal_basal_metabolism1.20168932
65MP0008007_abnormal_cellular_replicative1.19939905
66MP0001730_embryonic_growth_arrest1.16940560
67MP0003115_abnormal_respiratory_system1.13280627
68MP0003136_yellow_coat_color1.12530037
69MP0001346_abnormal_lacrimal_gland1.09202383
70MP0000371_diluted_coat_color1.08607032
71MP0003567_abnormal_fetal_cardiomyocyte1.07936091
72MP0001324_abnormal_eye_pigmentation1.07932718
73MP0003091_abnormal_cell_migration1.06599067
74MP0000350_abnormal_cell_proliferation1.05913986
75MP0002970_abnormal_white_adipose1.05712207
76MP0002080_prenatal_lethality1.05553567
77MP0000751_myopathy1.03747659
78MP0002932_abnormal_joint_morphology1.03206192
79MP0002111_abnormal_tail_morphology1.02108638
80MP0001929_abnormal_gametogenesis1.01675923
81MP0000703_abnormal_thymus_morphology1.01350064
82MP0000490_abnormal_crypts_of1.00778469
83MP0003984_embryonic_growth_retardation1.00481117
84MP0005621_abnormal_cell_physiology1.00062719
85MP0002092_abnormal_eye_morphology0.99682814
86MP0002089_abnormal_postnatal_growth/wei0.98409631
87MP0003045_fibrosis0.97733934
88MP0001270_distended_abdomen0.97215453
89MP0002088_abnormal_embryonic_growth/wei0.96906672
90MP0005220_abnormal_exocrine_pancreas0.96655615
91MP0003172_abnormal_lysosome_physiology0.95192050
92MP0000678_abnormal_parathyroid_gland0.94348107
93MP0000759_abnormal_skeletal_muscle0.93204053
94MP0003935_abnormal_craniofacial_develop0.93041031
95MP0005375_adipose_tissue_phenotype0.92947123
96MP0005257_abnormal_intraocular_pressure0.92880818
97MP0001145_abnormal_male_reproductive0.92376858
98MP0000579_abnormal_nail_morphology0.90843822
99MP0001340_abnormal_eyelid_morphology0.90843501
100MP0000049_abnormal_middle_ear0.90789508
101MP0010307_abnormal_tumor_latency0.90723219
102MP0001348_abnormal_lacrimal_gland0.89405802
103MP0005253_abnormal_eye_physiology0.89387771
104MP0004858_abnormal_nervous_system0.88775529
105MP0003453_abnormal_keratinocyte_physiol0.87014227
106MP0004130_abnormal_muscle_cell0.85896782
107MP0009703_decreased_birth_body0.84079437
108MP0002751_abnormal_autonomic_nervous0.83896409
109MP0003698_abnormal_male_reproductive0.83398721
110MP0005391_vision/eye_phenotype0.82295380
111MP0002075_abnormal_coat/hair_pigmentati0.81914988
112MP0002210_abnormal_sex_determination0.81449432
113MP0003755_abnormal_palate_morphology0.81142787
114MP0002697_abnormal_eye_size0.80627717
115MP0010630_abnormal_cardiac_muscle0.79236843
116MP0005501_abnormal_skin_physiology0.79207186
117MP0002114_abnormal_axial_skeleton0.78513150
118MP0002160_abnormal_reproductive_system0.78394618
119MP0000534_abnormal_ureter_morphology0.77444107
120MP0005187_abnormal_penis_morphology0.77249799
121MP0002019_abnormal_tumor_incidence0.76351280
122MP0009115_abnormal_fat_cell0.76287447
123MP0005266_abnormal_metabolism0.75958215
124MP0002116_abnormal_craniofacial_bone0.75802894
125MP0000566_synostosis0.74848270
126MP0008770_decreased_survivor_rate0.74612423
127MP0004264_abnormal_extraembryonic_tissu0.74024332
128MP0005666_abnormal_adipose_tissue0.73605387
129MP0003566_abnormal_cell_adhesion0.73586695
130MP0002925_abnormal_cardiovascular_devel0.73573680
131MP0003385_abnormal_body_wall0.73537331
132MP0001186_pigmentation_phenotype0.73508279
133MP0003123_paternal_imprinting0.72380834
134MP0002877_abnormal_melanocyte_morpholog0.72234332
135MP0000462_abnormal_digestive_system0.72163181
136MP0003943_abnormal_hepatobiliary_system0.71522016
137MP0000313_abnormal_cell_death0.71067065
138MP0002081_perinatal_lethality0.70002935
139MP0000432_abnormal_head_morphology0.69834185
140MP0004087_abnormal_muscle_fiber0.69779569
141MP0009053_abnormal_anal_canal0.69064735
142MP0000747_muscle_weakness0.68530889
143MP0002161_abnormal_fertility/fecundity0.68123526
144MP0000762_abnormal_tongue_morphology0.67219831
145MP0000653_abnormal_sex_gland0.66525157
146MP0005075_abnormal_melanosome_morpholog0.65886468
147MP0005647_abnormal_sex_gland0.65311956
148MP0000955_abnormal_spinal_cord0.64993294
149MP0005248_abnormal_Harderian_gland0.64415885
150MP0000358_abnormal_cell_content/0.62885406
151MP0003137_abnormal_impulse_conducting0.62640645
152MP0003861_abnormal_nervous_system0.62636507
153MP0005508_abnormal_skeleton_morphology0.62004708

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)4.34342571
2Neoplasm of the oral cavity (HP:0100649)4.11547506
3Osteomalacia (HP:0002749)4.11137334
4Rib fusion (HP:0000902)4.03071735
5Concave nail (HP:0001598)3.65007791
6Dysmetric saccades (HP:0000641)3.61637374
7Facial hemangioma (HP:0000329)3.60279602
8Congenital glaucoma (HP:0001087)3.50857683
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47722910
10Turricephaly (HP:0000262)3.47111754
11Ulnar bowing (HP:0003031)3.39042881
12Rectal fistula (HP:0100590)3.36835437
13Rectovaginal fistula (HP:0000143)3.36835437
14Cheilitis (HP:0100825)3.32483510
15Intestinal atresia (HP:0011100)3.28832732
16Increased IgM level (HP:0003496)3.28184934
17Short humerus (HP:0005792)3.25201039
18Intestinal fistula (HP:0100819)3.24334071
19Chromsome breakage (HP:0040012)3.21158699
20Hyperparathyroidism (HP:0000843)3.19838901
21Orthostatic hypotension (HP:0001278)3.13782282
22Aplasia/hypoplasia of the humerus (HP:0006507)3.10748208
23Albinism (HP:0001022)3.09665646
24Alopecia of scalp (HP:0002293)3.05128260
25Coronal craniosynostosis (HP:0004440)3.03730361
26Volvulus (HP:0002580)3.01700193
27Long eyelashes (HP:0000527)3.01684259
28Abnormality of the fingertips (HP:0001211)2.97054778
29Vaginal fistula (HP:0004320)2.96649977
30Hypochromic microcytic anemia (HP:0004840)2.94924070
31Tongue fasciculations (HP:0001308)2.93299240
32Abnormality of the lower motor neuron (HP:0002366)2.93059801
33Abnormality of the columella (HP:0009929)2.92842342
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.91237619
35Vertebral hypoplasia (HP:0008417)2.91237619
36Cerebral aneurysm (HP:0004944)2.89543546
37Abnormality of dentin (HP:0010299)2.88506661
38Overlapping toe (HP:0001845)2.88035957
39Squamous cell carcinoma (HP:0002860)2.83549031
40Urethral obstruction (HP:0000796)2.82518970
41Poikiloderma (HP:0001029)2.81129760
42Abnormal hemoglobin (HP:0011902)2.79185941
43Selective tooth agenesis (HP:0001592)2.78336178
44Male infertility (HP:0003251)2.77289276
45High anterior hairline (HP:0009890)2.75659638
46Hypotelorism (HP:0000601)2.74681353
47Abnormality of the periventricular white matter (HP:0002518)2.72262470
48Broad alveolar ridges (HP:0000187)2.72009092
49Birth length less than 3rd percentile (HP:0003561)2.69858974
50Muscle fibrillation (HP:0010546)2.69686158
51Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.69639733
52Pustule (HP:0200039)2.69225237
53Abnormality of calcium-phosphate metabolism (HP:0100530)2.68821802
54Broad face (HP:0000283)2.61226363
55Dysautonomia (HP:0002459)2.59534942
56Buphthalmos (HP:0000557)2.54601039
57Generalized hypopigmentation (HP:0007513)2.53737751
58Short chin (HP:0000331)2.50956045
59Anteriorly placed anus (HP:0001545)2.50534791
60Pancreatic islet-cell hyperplasia (HP:0004510)2.47681490
61Alacrima (HP:0000522)2.46448781
62Dislocated radial head (HP:0003083)2.46388154
63Congenital hip dislocation (HP:0001374)2.41027069
64Asymmetry of the thorax (HP:0001555)2.40612471
65Deep palmar crease (HP:0006191)2.37355473
66Bifid uvula (HP:0000193)2.33974658
67Clumsiness (HP:0002312)2.33511210
68Tented upper lip vermilion (HP:0010804)2.32310325
69Premature skin wrinkling (HP:0100678)2.30507374
70Ectopic kidney (HP:0000086)2.29753736
71Abnormality of DNA repair (HP:0003254)2.28425980
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28096790
73Prominent metopic ridge (HP:0005487)2.26409032
74Abnormality of the radial head (HP:0003995)2.25847859
75Absent thumb (HP:0009777)2.25460277
76Large for gestational age (HP:0001520)2.25163852
77Patellar aplasia (HP:0006443)2.23128196
78Premature graying of hair (HP:0002216)2.22438298
79Prominent nose (HP:0000448)2.20956897
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.20946960
81Hypercortisolism (HP:0001578)2.20536399
82Increased number of teeth (HP:0011069)2.19836087
83Growth hormone excess (HP:0000845)2.19672956
84Flat cornea (HP:0007720)2.19580869
85Progressive muscle weakness (HP:0003323)2.18675278
86Hypoplasia of the radius (HP:0002984)2.18333003
87Abnormality of the thoracic spine (HP:0100711)2.17916957
88Sparse lateral eyebrow (HP:0005338)2.17470303
89Abnormality of the aortic arch (HP:0012303)2.16350869
90Hypoplastic ischia (HP:0003175)2.16224497
91Abnormal respiratory motile cilium morphology (HP:0005938)2.14633930
92Abnormal respiratory epithelium morphology (HP:0012253)2.14633930
93Absent radius (HP:0003974)2.14011581
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13292657
95Renovascular hypertension (HP:0100817)2.12566480
96Basal cell carcinoma (HP:0002671)2.09145867
97Sandal gap (HP:0001852)2.07643684
98Colitis (HP:0002583)2.06581071
99Capillary hemangiomas (HP:0005306)2.06502753
100Protruding tongue (HP:0010808)2.06249012
101Renal duplication (HP:0000075)2.06142646
102Acute lymphatic leukemia (HP:0006721)2.06102904
103Slender long bone (HP:0003100)2.00820199
104Heterotopia (HP:0002282)2.00416276
105Thoracic kyphosis (HP:0002942)1.99467174
106Narrow nasal bridge (HP:0000446)1.99050982
107Abnormality of cochlea (HP:0000375)1.98832491
108Pointed chin (HP:0000307)1.98786491
109Self-mutilation (HP:0000742)1.98423051
110Aplasia/Hypoplasia of the patella (HP:0006498)1.98145014
111Spina bifida occulta (HP:0003298)1.98040544
112Absent forearm bone (HP:0003953)1.97687534
113Aplasia involving forearm bones (HP:0009822)1.97687534
114Trigonocephaly (HP:0000243)1.97626020
115Bowing of the arm (HP:0006488)1.97494136
116Bowed forearm bones (HP:0003956)1.97494136
117Microvesicular hepatic steatosis (HP:0001414)1.96424506
118Diaphragmatic weakness (HP:0009113)1.96313519
119Hypoplastic labia majora (HP:0000059)1.95628655
120Genetic anticipation (HP:0003743)1.95438484
121Insomnia (HP:0100785)1.93634757
122Abnormality of the ischium (HP:0003174)1.93566143
123Spinal cord lesions (HP:0100561)1.93510235
124Syringomyelia (HP:0003396)1.93510235
125Hamartoma (HP:0010566)1.93350174
126Macroorchidism (HP:0000053)1.92982595
127Hypopigmentation of the fundus (HP:0007894)1.92925745
128Hyperacusis (HP:0010780)1.92909721
129Thin ribs (HP:0000883)1.91912446
130Abnormality of the labia minora (HP:0012880)1.90858100
131Abnormality of the phalanges of the hallux (HP:0010057)1.90719341
132Elfin facies (HP:0004428)1.90654407
133Lip pit (HP:0100267)1.90133495
134Abnormality of male internal genitalia (HP:0000022)1.90074777
135Obsessive-compulsive behavior (HP:0000722)1.89256257
136Abnormality of the metopic suture (HP:0005556)1.87640495
137Patellar dislocation (HP:0002999)1.86716751
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.85357028
139Disproportionate tall stature (HP:0001519)1.84973028
140Flat acetabular roof (HP:0003180)1.84942236
141Anal stenosis (HP:0002025)1.84173145
142Broad nasal tip (HP:0000455)1.84112281
143Choanal stenosis (HP:0000452)1.84102990
144Long palpebral fissure (HP:0000637)1.83147898
145Vertebral fusion (HP:0002948)1.82538321
146Narrow palate (HP:0000189)1.82299876
147Short thumb (HP:0009778)1.82084263
148Proximal tubulopathy (HP:0000114)1.81574301
149Abnormality of the labia majora (HP:0012881)1.81249962
150Gastrointestinal atresia (HP:0002589)1.80756786
151Polycythemia (HP:0001901)1.79850146
152Obstructive sleep apnea (HP:0002870)1.77560866
153Smooth philtrum (HP:0000319)1.77277018
154Infertility (HP:0000789)1.76134306
155Hypercalciuria (HP:0002150)1.75685197
156Preauricular skin tag (HP:0000384)1.75508811
157Cafe-au-lait spot (HP:0000957)1.75215123
158Deep philtrum (HP:0002002)1.74719986
159IgA deficiency (HP:0002720)1.74069211
160High pitched voice (HP:0001620)1.73968826
161Germ cell neoplasia (HP:0100728)1.73872483
162Abnormality of the nasal septum (HP:0000419)1.70526807
163Relative macrocephaly (HP:0004482)1.69803250
164Duplicated collecting system (HP:0000081)1.69569474
165Skin tags (HP:0010609)1.69534293
166Ankyloglossia (HP:0010296)1.69489232
167Progressive external ophthalmoplegia (HP:0000590)1.68561998
168Duplication of thumb phalanx (HP:0009942)1.68326963
169Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67307990
170Abnormality of the carotid arteries (HP:0005344)1.63995721
171Broad thumb (HP:0011304)1.63965164
172Increased nuchal translucency (HP:0010880)1.63810619
173Broad distal phalanx of finger (HP:0009836)1.63320677
174Deviation of the thumb (HP:0009603)1.62675471
175Morphological abnormality of the inner ear (HP:0011390)1.61469330
176Abnormality of the humeroradial joint (HP:0100744)1.60182170
177Overriding aorta (HP:0002623)1.59930175
178Partial agenesis of the corpus callosum (HP:0001338)1.59139741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.51852412
2DDR24.87808302
3MAPK154.53318872
4MAP3K63.63823015
5SMG13.18247328
6TYRO32.80180668
7MAP3K112.63993979
8PKN22.55400348
9PINK12.54117731
10FGR2.39910607
11MATK2.37614687
12PDGFRA2.28850872
13DYRK1B2.26951236
14PIM22.26778046
15DAPK12.26605758
16UHMK12.20268942
17SIK12.19898859
18PRKD22.09870822
19BMX1.91863226
20CAMK1D1.89449281
21PIK3CG1.86961687
22CDK71.82242923
23YES11.76980007
24BRD41.74843815
25CSK1.70948695
26CAMK1G1.58942520
27AKT31.58922190
28MAP3K71.55293960
29MAP3K101.53232589
30TRPM71.48280242
31LATS21.48043824
32MELK1.39823361
33CHEK21.36903530
34DYRK31.35524984
35RPS6KL11.33310588
36RPS6KC11.33310588
37PRKD31.30471657
38PIM11.29931458
39CDC42BPA1.29623023
40FGFR41.26430588
41FLT31.23127495
42MARK21.12948420
43CDK61.11279517
44RPS6KA61.10627099
45CDK41.08340389
46TTN1.07606668
47LATS11.05998166
48HIPK21.03682979
49ATR1.02832507
50GSK3A0.99590991
51PRKAA10.98203257
52PHKG20.95901949
53PHKG10.95901949
54MTOR0.95432859
55NME10.92065738
56TESK20.91978381
57CDK80.91052714
58PLK10.87055215
59PDK30.86019021
60PDK40.86019021
61MAP2K30.85264063
62MAP3K130.81971459
63ACVR1B0.79424527
64MARK30.77969764
65PTK60.77693170
66MST1R0.76911616
67RPS6KB20.76301096
68IRAK30.74847498
69FGFR20.74419422
70RPS6KA10.74341025
71FRK0.73708378
72CDK120.73425051
73PDGFRB0.72865026
74EPHA20.72834649
75RET0.71625250
76MAPK110.70944631
77ALK0.70490893
78MAPK120.67345397
79NEK20.65228026
80CDK20.63962916
81CHEK10.63588684
82PDPK10.62966585
83TLK10.61029912
84KSR20.59514035
85CDC70.58130697
86RPS6KB10.56736561
87NTRK10.56100803
88FGFR30.55822459
89PTK20.54328692
90EGFR0.50936854
91SGK30.50753537
92TTK0.49451392
93PTK2B0.49418458
94SGK10.49237392
95CSNK1E0.48880559
96CAMKK10.47679653
97NEK60.47168732
98ATM0.47130888
99EEF2K0.46413846
100SGK4940.46331204
101SGK2230.46331204
102TNK20.45436495
103RIPK10.44723592
104BMPR1B0.44192529
105PDK20.44130167
106CSNK2A20.43851718
107MAP4K10.43773360
108INSR0.43742827
109BTK0.43557035
110MAPK140.43173582
111JAK30.42782527
112CSNK2A10.42512194
113RPS6KA20.42247205
114ERN10.41863945
115WNK10.40823713
116MAPK80.40709553
117CAMK40.40699177
118CLK10.40608462
119STK40.38751292
120SGK20.38706668
121CDK10.38185965
122PAK20.37247435
123MAPK10.36830117
124FGFR10.36288698
125NME20.36117615
126PDK10.35674120
127PRPF4B0.35276617
128RAF10.34672609
129NEK10.34497282
130ZAK0.34315245
131AURKB0.33585941
132MAP3K80.33576367
133ERBB30.33228976
134MAP3K90.32852120
135MAPK100.32534571
136TRIB30.32518462
137AKT10.32139212
138SIK20.31152639
139CSNK1G10.30856699
140DYRK20.30711757
141TESK10.28626785
142AURKA0.28614682
143STK380.26958236
144MET0.26539382
145GSK3B0.26085937
146PRKD10.25682237
147MAPK30.25658169
148PRKDC0.24524794
149RPS6KA30.23968970
150PAK60.23852619

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.37918714
2Fatty acid biosynthesis_Homo sapiens_hsa000614.09792979
3Mismatch repair_Homo sapiens_hsa034303.93776862
4DNA replication_Homo sapiens_hsa030303.38909879
5Nucleotide excision repair_Homo sapiens_hsa034202.85916451
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71708737
7mRNA surveillance pathway_Homo sapiens_hsa030152.58658940
8Spliceosome_Homo sapiens_hsa030402.54117016
9Circadian rhythm_Homo sapiens_hsa047102.26731000
10RNA transport_Homo sapiens_hsa030132.22406071
11Hedgehog signaling pathway_Homo sapiens_hsa043402.10032261
12mTOR signaling pathway_Homo sapiens_hsa041502.00861793
13Non-small cell lung cancer_Homo sapiens_hsa052231.94346518
14Fanconi anemia pathway_Homo sapiens_hsa034601.80084812
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79771527
16Hippo signaling pathway_Homo sapiens_hsa043901.74661804
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.73123715
18Cell cycle_Homo sapiens_hsa041101.66780877
19Biosynthesis of amino acids_Homo sapiens_hsa012301.65783526
20Thyroid cancer_Homo sapiens_hsa052161.63012942
21p53 signaling pathway_Homo sapiens_hsa041151.50766226
22Notch signaling pathway_Homo sapiens_hsa043301.50097546
23Homologous recombination_Homo sapiens_hsa034401.47038779
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41963970
25Wnt signaling pathway_Homo sapiens_hsa043101.40631730
26Adherens junction_Homo sapiens_hsa045201.38427175
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37869147
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.36617526
29Pancreatic cancer_Homo sapiens_hsa052121.34285986
30Prostate cancer_Homo sapiens_hsa052151.27877974
31Lysine degradation_Homo sapiens_hsa003101.27293886
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24318072
33Oocyte meiosis_Homo sapiens_hsa041141.20524035
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18115499
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17849297
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14123730
37VEGF signaling pathway_Homo sapiens_hsa043701.13699351
38One carbon pool by folate_Homo sapiens_hsa006701.13181985
39Basal cell carcinoma_Homo sapiens_hsa052171.12833254
40Bladder cancer_Homo sapiens_hsa052191.10874148
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10210219
42TGF-beta signaling pathway_Homo sapiens_hsa043501.07630565
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06206757
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.02456691
45Renal cell carcinoma_Homo sapiens_hsa052111.02443114
46FoxO signaling pathway_Homo sapiens_hsa040680.99991323
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96263254
48Viral carcinogenesis_Homo sapiens_hsa052030.94194438
49Arginine and proline metabolism_Homo sapiens_hsa003300.94151623
50Fructose and mannose metabolism_Homo sapiens_hsa000510.93289543
51Chronic myeloid leukemia_Homo sapiens_hsa052200.92557702
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91235974
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90113049
54Type II diabetes mellitus_Homo sapiens_hsa049300.89768992
55B cell receptor signaling pathway_Homo sapiens_hsa046620.89639139
56Melanogenesis_Homo sapiens_hsa049160.88904577
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88825480
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.86615503
59Colorectal cancer_Homo sapiens_hsa052100.86151805
60Sulfur relay system_Homo sapiens_hsa041220.84333804
61MicroRNAs in cancer_Homo sapiens_hsa052060.83185078
62Ribosome_Homo sapiens_hsa030100.81042880
63Insulin resistance_Homo sapiens_hsa049310.80998292
64Prolactin signaling pathway_Homo sapiens_hsa049170.80908183
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80840653
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.80764296
67Hepatitis B_Homo sapiens_hsa051610.80455052
68GnRH signaling pathway_Homo sapiens_hsa049120.80254525
69Shigellosis_Homo sapiens_hsa051310.79682027
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79371025
71Glucagon signaling pathway_Homo sapiens_hsa049220.76554253
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75898034
73Gap junction_Homo sapiens_hsa045400.75722809
74ErbB signaling pathway_Homo sapiens_hsa040120.75436108
75Primary immunodeficiency_Homo sapiens_hsa053400.74821201
76Non-homologous end-joining_Homo sapiens_hsa034500.72683076
77Insulin signaling pathway_Homo sapiens_hsa049100.72590470
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71640677
79Apoptosis_Homo sapiens_hsa042100.70696021
80Inositol phosphate metabolism_Homo sapiens_hsa005620.70296692
81Systemic lupus erythematosus_Homo sapiens_hsa053220.69209992
82Tight junction_Homo sapiens_hsa045300.68626561
83Vitamin B6 metabolism_Homo sapiens_hsa007500.68136603
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.67645844
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66923551
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65010104
87ABC transporters_Homo sapiens_hsa020100.64942405
88Basal transcription factors_Homo sapiens_hsa030220.64540774
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63931645
90AMPK signaling pathway_Homo sapiens_hsa041520.63794883
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62101375
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61434947
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60992537
94T cell receptor signaling pathway_Homo sapiens_hsa046600.60090062
95Cholinergic synapse_Homo sapiens_hsa047250.59883805
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59493165
97Small cell lung cancer_Homo sapiens_hsa052220.57292403
98Axon guidance_Homo sapiens_hsa043600.56532160
99Oxytocin signaling pathway_Homo sapiens_hsa049210.55648409
100Alcoholism_Homo sapiens_hsa050340.55057799
101Acute myeloid leukemia_Homo sapiens_hsa052210.54254525
102Long-term potentiation_Homo sapiens_hsa047200.54067781
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54015217
104Hepatitis C_Homo sapiens_hsa051600.53607231
105Dorso-ventral axis formation_Homo sapiens_hsa043200.53161828
106HTLV-I infection_Homo sapiens_hsa051660.52838771
107HIF-1 signaling pathway_Homo sapiens_hsa040660.51608607
108MAPK signaling pathway_Homo sapiens_hsa040100.51437613
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.50910268
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.49793466
111Pyrimidine metabolism_Homo sapiens_hsa002400.49032984
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47984894
113Epstein-Barr virus infection_Homo sapiens_hsa051690.44829516
114Proteoglycans in cancer_Homo sapiens_hsa052050.43824415
115Galactose metabolism_Homo sapiens_hsa000520.43778235
116Estrogen signaling pathway_Homo sapiens_hsa049150.43339320
117Folate biosynthesis_Homo sapiens_hsa007900.42773167
118Choline metabolism in cancer_Homo sapiens_hsa052310.42598325
119Glioma_Homo sapiens_hsa052140.40960703
120Focal adhesion_Homo sapiens_hsa045100.38842488
121Herpes simplex infection_Homo sapiens_hsa051680.38602049
122Viral myocarditis_Homo sapiens_hsa054160.37006970
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36218840
124Arginine biosynthesis_Homo sapiens_hsa002200.36152027
125Pyruvate metabolism_Homo sapiens_hsa006200.34578727
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33574267
127Fatty acid metabolism_Homo sapiens_hsa012120.32233964
128Pathways in cancer_Homo sapiens_hsa052000.30531572
129RNA degradation_Homo sapiens_hsa030180.30467902
130Selenocompound metabolism_Homo sapiens_hsa004500.29844004
131Legionellosis_Homo sapiens_hsa051340.28795489
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28408575
133N-Glycan biosynthesis_Homo sapiens_hsa005100.26547389
134Melanoma_Homo sapiens_hsa052180.23506898
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.22704549
136Endometrial cancer_Homo sapiens_hsa052130.22590765
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19050974
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18006715

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