JRKL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.41666142
2response to pheromone (GO:0019236)7.92322629
3chromosome condensation (GO:0030261)7.88999492
4fusion of sperm to egg plasma membrane (GO:0007342)7.79590335
5sperm motility (GO:0030317)7.58087755
6DNA packaging (GO:0006323)7.53338186
7interleukin-6-mediated signaling pathway (GO:0070102)6.54372332
8negative regulation of JUN kinase activity (GO:0043508)6.53421829
9microtubule depolymerization (GO:0007019)6.36496758
10plasma membrane fusion (GO:0045026)6.01977338
11sperm capacitation (GO:0048240)5.94273047
12centriole replication (GO:0007099)5.81036418
13single strand break repair (GO:0000012)5.66422721
14DNA damage response, detection of DNA damage (GO:0042769)5.62600200
15nuclear pore complex assembly (GO:0051292)5.62180354
16protein targeting to Golgi (GO:0000042)5.59160817
17axonemal dynein complex assembly (GO:0070286)5.55145943
18regulation of centriole replication (GO:0046599)5.54198714
19rRNA methylation (GO:0031167)5.40400790
20regulation of T-helper 2 cell differentiation (GO:0045628)5.19381460
21establishment of protein localization to Golgi (GO:0072600)5.13167067
22retrograde transport, vesicle recycling within Golgi (GO:0000301)5.10727256
23centriole assembly (GO:0098534)5.02872067
24microtubule polymerization or depolymerization (GO:0031109)4.93805874
25spermatid development (GO:0007286)4.90092973
26sperm-egg recognition (GO:0035036)4.79658563
27binding of sperm to zona pellucida (GO:0007339)4.79429751
28neutrophil mediated immunity (GO:0002446)4.74797520
29CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.69107653
30cellular glucuronidation (GO:0052695)4.68602780
31sexual reproduction (GO:0019953)4.62649025
32regulation of transmission of nerve impulse (GO:0051969)4.62468025
33peptidyl-proline hydroxylation (GO:0019511)4.60453373
34nuclear pore organization (GO:0006999)4.57780864
35regulation of type B pancreatic cell apoptotic process (GO:2000674)4.52846165
36regulation of cilium movement (GO:0003352)4.51736177
37response to peptidoglycan (GO:0032494)4.49429256
38nucleotide transmembrane transport (GO:1901679)4.47317877
39cilium or flagellum-dependent cell motility (GO:0001539)4.47159754
40positive regulation of neurological system process (GO:0031646)4.44285602
41glycerol ether metabolic process (GO:0006662)4.34670001
42motile cilium assembly (GO:0044458)4.30662976
43ketone body metabolic process (GO:1902224)4.30219326
44branching involved in salivary gland morphogenesis (GO:0060445)4.28824328
45glucuronate metabolic process (GO:0019585)4.22134642
46uronic acid metabolic process (GO:0006063)4.22134642
47pore complex assembly (GO:0046931)4.19670759
48negative regulation of gluconeogenesis (GO:0045721)4.19512695
49dopamine biosynthetic process (GO:0042416)4.12242441
50spermatogenesis (GO:0007283)4.05139527
51male gamete generation (GO:0048232)4.04811801
52reproduction (GO:0000003)4.00738920
53rRNA modification (GO:0000154)3.99102917
54multicellular organism reproduction (GO:0032504)3.98897566
55negative regulation of inclusion body assembly (GO:0090084)3.98412426
56protein hydroxylation (GO:0018126)3.96037754
57protein localization to Golgi apparatus (GO:0034067)3.88965594
58ether metabolic process (GO:0018904)3.86547157
59glomerular visceral epithelial cell development (GO:0072015)3.86091141
60cell-cell recognition (GO:0009988)3.82785232
61melanin biosynthetic process (GO:0042438)3.80939161
62nucleus organization (GO:0006997)3.80854037
63glomerular epithelial cell development (GO:0072310)3.79338665
64regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.78726534
65iron ion import (GO:0097286)3.78485938
66calcium ion-dependent exocytosis (GO:0017156)3.76006531
67positive regulation of protein import into nucleus, translocation (GO:0033160)3.72410454
68gamete generation (GO:0007276)3.71032420
69cell wall macromolecule metabolic process (GO:0044036)3.64323181
70myeloid leukocyte mediated immunity (GO:0002444)3.63565317
71melanin metabolic process (GO:0006582)3.59407774
72epithelial cilium movement (GO:0003351)3.58237937
73cellular ketone body metabolic process (GO:0046950)3.56701103
74phosphatidylethanolamine metabolic process (GO:0046337)3.55112791
75response to nitrosative stress (GO:0051409)3.52282621
76positive regulation of type 2 immune response (GO:0002830)3.49495018
77spermatid nucleus differentiation (GO:0007289)3.47391051
78cilium movement (GO:0003341)3.43113772
79microtubule severing (GO:0051013)3.41507233
80phosphatidylethanolamine biosynthetic process (GO:0006646)3.39883525
81dopaminergic neuron differentiation (GO:0071542)3.38610052
82regulation of immunoglobulin secretion (GO:0051023)3.35476031
83bone remodeling (GO:0046849)3.34269301
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33906523
85regulation of energy homeostasis (GO:2000505)3.32847941
86protein polyglutamylation (GO:0018095)3.31208095
87T cell lineage commitment (GO:0002360)3.27773182
88positive regulation of Rab GTPase activity (GO:0032851)3.20366724
89regulation of Rab GTPase activity (GO:0032313)3.20366724
90response to insecticide (GO:0017085)3.18330294
91limb bud formation (GO:0060174)3.16879313
92pyrimidine-containing compound transmembrane transport (GO:0072531)3.13975855
93neuron maturation (GO:0042551)3.13576810
94cell wall macromolecule catabolic process (GO:0016998)3.12793831
95single fertilization (GO:0007338)3.12301847
96monocyte chemotaxis (GO:0002548)3.12142540
97regulation of DNA endoreduplication (GO:0032875)3.11702907
98chromatin silencing (GO:0006342)3.11269056
99multicellular organismal reproductive process (GO:0048609)3.05632779
100DNA conformation change (GO:0071103)3.04647264
101cortical actin cytoskeleton organization (GO:0030866)3.04060194
102amyloid precursor protein catabolic process (GO:0042987)3.01861642
103negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00758900
104negative regulation of cell killing (GO:0031342)3.00758900
105mitotic G2 DNA damage checkpoint (GO:0007095)2.96295904
106positive regulation of T-helper cell differentiation (GO:0045624)2.93982981
107secondary metabolite biosynthetic process (GO:0044550)2.93905366
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.93864602
109lipid translocation (GO:0034204)2.93614242
110phospholipid translocation (GO:0045332)2.93614242
111cellular process involved in reproduction in multicellular organism (GO:0022412)2.93568710
112dorsal/ventral axis specification (GO:0009950)2.91366073
113membrane protein intracellular domain proteolysis (GO:0031293)2.90634378
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88057968
115import into cell (GO:0098657)2.87045084
116regulation of histone H3-K27 methylation (GO:0061085)2.86403620
117mitotic G1 DNA damage checkpoint (GO:0031571)2.85450093
118COPII vesicle coating (GO:0048208)2.84932537
119protein-chromophore linkage (GO:0018298)2.84688211
120negative regulation of chemokine production (GO:0032682)2.83020564
121negative regulation of neurotransmitter secretion (GO:0046929)2.82455865
122positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.81035545
123microtubule nucleation (GO:0007020)2.80438465
124germ cell development (GO:0007281)2.79483085
125cortical cytoskeleton organization (GO:0030865)2.79337368
126mesenchymal cell differentiation involved in renal system development (GO:2001012)2.78767786
127mesenchymal cell differentiation involved in kidney development (GO:0072161)2.78767786
128catecholamine biosynthetic process (GO:0042423)2.78565425
129catechol-containing compound biosynthetic process (GO:0009713)2.78565425
130chondrocyte proliferation (GO:0035988)2.75881530
1314-hydroxyproline metabolic process (GO:0019471)2.72777234
132centrosome duplication (GO:0051298)2.71953014
133metanephric mesenchyme development (GO:0072075)2.67846918
134response to lipoprotein particle (GO:0055094)2.67745600
135regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66992787
136regulation of chromatin binding (GO:0035561)2.66936241
137genitalia morphogenesis (GO:0035112)2.65639695
138regulation of secondary heart field cardioblast proliferation (GO:0003266)2.65413364
139regulation of cardioblast proliferation (GO:0003264)2.65413364
140negative regulation of lipid storage (GO:0010888)2.64243248
141histone mRNA catabolic process (GO:0071044)2.63614459
142intra-Golgi vesicle-mediated transport (GO:0006891)2.62582305
143phosphatidylinositol dephosphorylation (GO:0046856)2.62032821
144negative regulation of chondrocyte differentiation (GO:0032331)2.61432252
145fertilization (GO:0009566)2.60507007
146nucleotide transport (GO:0006862)2.59336085
147positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.57807875
148regulation of inclusion body assembly (GO:0090083)2.57684982
149regulation of centrosome duplication (GO:0010824)2.57424893
150histone H3-K4 trimethylation (GO:0080182)2.57364880
151eosinophil chemotaxis (GO:0048245)2.57316374
152membrane protein ectodomain proteolysis (GO:0006509)2.57179091
153negative regulation of JNK cascade (GO:0046329)2.56972837
154coenzyme catabolic process (GO:0009109)2.56152515
155homeostasis of number of cells within a tissue (GO:0048873)2.55663158
156myoblast migration (GO:0051451)2.55557279
157establishment of epithelial cell polarity (GO:0090162)2.55455792
158Golgi to endosome transport (GO:0006895)2.55336983
159activated T cell proliferation (GO:0050798)2.55290866
160negative regulation of fatty acid transport (GO:2000192)2.53599252
161regulation of heat generation (GO:0031650)2.53357140
162regulation of chemokine biosynthetic process (GO:0045073)2.52769424
163actin filament depolymerization (GO:0030042)2.50040026
164neuron fate determination (GO:0048664)2.48574575
165amyloid precursor protein metabolic process (GO:0042982)2.48223233
166positive regulation of cellular amide metabolic process (GO:0034250)2.47871267
167suckling behavior (GO:0001967)2.47663463
168negative regulation of phagocytosis (GO:0050765)2.46467626
169kidney mesenchyme development (GO:0072074)2.45899245
170cerebral cortex radially oriented cell migration (GO:0021799)2.44749970
171phospholipid dephosphorylation (GO:0046839)2.44519701
172regulation of lipoprotein metabolic process (GO:0050746)2.43780297
173ER overload response (GO:0006983)2.42714979
174mechanosensory behavior (GO:0007638)2.40143289
175metanephric nephron epithelium development (GO:0072243)2.38556107
176regulation of cell fate specification (GO:0042659)2.37959964
177regulation of fibroblast apoptotic process (GO:2000269)2.37185670
178negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36007198
179L-amino acid import (GO:0043092)2.35528776
180muscle cell cellular homeostasis (GO:0046716)2.35115561
181negative regulation of neurotransmitter transport (GO:0051589)2.34978789
182regulation of dopamine metabolic process (GO:0042053)2.32755925
183regulation of catecholamine metabolic process (GO:0042069)2.32755925
184regulation of T-helper cell differentiation (GO:0045622)2.31823845
185central nervous system myelination (GO:0022010)2.30987693
186axon ensheathment in central nervous system (GO:0032291)2.30987693
187negative regulation of stress-activated MAPK cascade (GO:0032873)2.27566927
188negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)2.27566927
189cellular response to interleukin-6 (GO:0071354)2.27464884
190peripheral nervous system axon ensheathment (GO:0032292)2.26707112
191myelination in peripheral nervous system (GO:0022011)2.26707112
192regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.26234722
193negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.25493560
194chondroitin sulfate biosynthetic process (GO:0030206)2.24763250
195eosinophil migration (GO:0072677)2.23826020
196defense response to protozoan (GO:0042832)2.22499682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.42018802
2GATA1_22025678_ChIP-Seq_K562_Human3.59814602
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48634921
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39179161
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31292935
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.11913616
7WT1_19549856_ChIP-ChIP_CCG9911_Human3.01657327
8VDR_22108803_ChIP-Seq_LS180_Human2.84638555
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.56431889
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.55159392
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46466012
12GBX2_23144817_ChIP-Seq_PC3_Human2.42443699
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27585963
14* BRD4_25478319_ChIP-Seq_HGPS_Human2.21290917
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20400535
16TP53_18474530_ChIP-ChIP_U2OS_Human2.20058047
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.17646206
18IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.10394219
19CBP_20019798_ChIP-Seq_JUKART_Human2.10394219
20PIAS1_25552417_ChIP-Seq_VCAP_Human2.00387826
21TAF15_26573619_Chip-Seq_HEK293_Human1.93845442
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.92707676
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92462654
24* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91230327
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90348087
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.84042530
27P300_19829295_ChIP-Seq_ESCs_Human1.79063268
28RUNX_20019798_ChIP-Seq_JUKART_Human1.77009857
29PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.71988588
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.66329811
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65418221
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65418221
33CLOCK_20551151_ChIP-Seq_293T_Human1.63475231
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62905630
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.59016029
36EWS_26573619_Chip-Seq_HEK293_Human1.58903603
37NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58739058
38NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58739058
39SALL4_22934838_ChIP-ChIP_CD34+_Human1.58039927
40JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57467187
41FUS_26573619_Chip-Seq_HEK293_Human1.54302083
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.54291847
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53233013
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.52287370
45TP63_23658742_ChIP-Seq_EP156T_Human1.51435042
46FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51105655
47JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48422905
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.46074097
49RXR_22108803_ChIP-Seq_LS180_Human1.44647502
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43652459
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43149751
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42287429
53TP53_16413492_ChIP-PET_HCT116_Human1.41488892
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40194003
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38671409
56IGF1R_20145208_ChIP-Seq_DFB_Human1.38232574
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38147913
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37485958
59CDX2_22108803_ChIP-Seq_LS180_Human1.35413980
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34405713
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34326414
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34203908
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33972260
64CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.33895917
65CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33578671
66AR_21909140_ChIP-Seq_LNCAP_Human1.33342157
67HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32420282
68VDR_24787735_ChIP-Seq_THP-1_Human1.32347821
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32063306
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31979209
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31635769
72AHR_22903824_ChIP-Seq_MCF-7_Human1.31120847
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31035865
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.30334713
75* NFYB_21822215_ChIP-Seq_K562_Human1.29372568
76RBPJ_21746931_ChIP-Seq_IB4_Human1.28969314
77RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28193403
78SMAD4_21799915_ChIP-Seq_A2780_Human1.27736308
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27523963
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27447830
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.27026126
82ETV1_20927104_ChIP-Seq_GIST48_Human1.27015376
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23621978
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22722206
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22712668
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22091695
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21989408
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21154250
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21029212
90TBL1_22424771_ChIP-Seq_293T_Human1.20382830
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19505678
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19427992
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19133827
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18820269
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.18720028
96TFEB_21752829_ChIP-Seq_HELA_Human1.18266592
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.18230029
98PHF8_20622853_ChIP-Seq_HELA_Human1.18119308
99BCAT_22108803_ChIP-Seq_LS180_Human1.17983504
100ERG_20517297_ChIP-Seq_VCAP_Human1.17477152
101ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17397647
102STAT3_23295773_ChIP-Seq_U87_Human1.16962572
103E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16896052
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16850224
105SALL1_21062744_ChIP-ChIP_HESCs_Human1.15644179
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14692510
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.13163270
108ER_23166858_ChIP-Seq_MCF-7_Human1.12987235
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12949268
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.12263001
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.11668968
112IRF8_27001747_Chip-Seq_BMDM_Mouse1.09991702
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.09494068
114NFYA_21822215_ChIP-Seq_K562_Human1.09158330
115AR_25329375_ChIP-Seq_VCAP_Human1.08948421
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08937226
117NFE2_27457419_Chip-Seq_LIVER_Mouse1.08683647
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08525165
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08480513
120FLI1_21867929_ChIP-Seq_TH2_Mouse1.08319102
121CJUN_26792858_Chip-Seq_BT549_Human1.07605900
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07118808
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06749781
124GATA6_21074721_ChIP-Seq_CACO-2_Human1.06411299
125* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05795110
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04851267
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04613801
128SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04361201
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03997537
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03811658
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.03662561
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03456285
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03233865
134SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02333818
135GATA1_19941826_ChIP-Seq_K562_Human1.02069618
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01935375
137NANOG_19829295_ChIP-Seq_ESCs_Human1.01469990
138SOX2_19829295_ChIP-Seq_ESCs_Human1.01469990
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01381568
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01296810
141LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01291314
142CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00788038
143SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00749149
144GATA2_19941826_ChIP-Seq_K562_Human1.00426659
145P300_18555785_Chip-Seq_ESCs_Mouse0.99205758
146MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98613764
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97918405
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95867356
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95682237
150FOXO3_23340844_ChIP-Seq_DLD1_Human0.95525942
151TCF4_23295773_ChIP-Seq_U87_Human0.94061290
152* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93464829
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93220560
154RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93220560
155NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92092991
156RUNX2_22187159_ChIP-Seq_PCA_Human0.91439550
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91090893
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90914236
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.90552318
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89889845
161TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89570898
162GATA3_27048872_Chip-Seq_THYMUS_Human0.88578926
163P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87687673
164VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.86628441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.49352845
2MP0005408_hypopigmentation3.59775742
3MP0003690_abnormal_glial_cell3.34830883
4MP0002877_abnormal_melanocyte_morpholog3.19994248
5MP0002254_reproductive_system_inflammat3.15380137
6MP0001346_abnormal_lacrimal_gland2.93335658
7MP0003279_aneurysm2.90304489
8MP0004134_abnormal_chest_morphology2.86726276
9MP0010234_abnormal_vibrissa_follicle2.69181182
10MP0009384_cardiac_valve_regurgitation2.62196051
11MP0003183_abnormal_peptide_metabolism2.61879479
12MP0002009_preneoplasia2.54136899
13MP0010030_abnormal_orbit_morphology2.30475650
14MP0000920_abnormal_myelination2.27673127
15MP0005248_abnormal_Harderian_gland2.12099085
16MP0001348_abnormal_lacrimal_gland2.10989335
17MP0003698_abnormal_male_reproductive2.02556773
18MP0001929_abnormal_gametogenesis2.02186069
19MP0005275_abnormal_skin_tensile1.97910088
20MP0004272_abnormal_basement_membrane1.97422764
21MP0003880_abnormal_central_pattern1.96332873
22MP0001299_abnormal_eye_distance/1.96216199
23MP0003950_abnormal_plasma_membrane1.93738247
24MP0003091_abnormal_cell_migration1.86860905
25MP0002132_abnormal_respiratory_system1.86841134
26MP0006082_CNS_inflammation1.86126364
27MP0008438_abnormal_cutaneous_collagen1.83460670
28MP0000647_abnormal_sebaceous_gland1.80732779
29MP0001177_atelectasis1.77586316
30MP0009250_abnormal_appendicular_skeleto1.75851397
31MP0003300_gastrointestinal_ulcer1.74290244
32MP0009697_abnormal_copulation1.67258754
33MP0002638_abnormal_pupillary_reflex1.64340416
34MP0001851_eye_inflammation1.62642574
35MP0001790_abnormal_immune_system1.61240097
36MP0005387_immune_system_phenotype1.61240097
37MP0005379_endocrine/exocrine_gland_phen1.61217702
38MP0002163_abnormal_gland_morphology1.59236693
39MP0003077_abnormal_cell_cycle1.55984918
40MP0006054_spinal_hemorrhage1.55156469
41MP0002332_abnormal_exercise_endurance1.52681428
42MP0001905_abnormal_dopamine_level1.43311027
43MP0005623_abnormal_meninges_morphology1.42697271
44MP0000372_irregular_coat_pigmentation1.42251910
45MP0004270_analgesia1.40337895
46MP0005646_abnormal_pituitary_gland1.39958279
47MP0002998_abnormal_bone_remodeling1.39711841
48MP0000013_abnormal_adipose_tissue1.38564278
49MP0003633_abnormal_nervous_system1.35159947
50MP0005166_decreased_susceptibility_to1.34603304
51MP0002060_abnormal_skin_morphology1.33177863
52MP0004808_abnormal_hematopoietic_stem1.32829774
53MP0003303_peritoneal_inflammation1.32196519
54MP0003634_abnormal_glial_cell1.31366315
55MP0005257_abnormal_intraocular_pressure1.30916095
56MP0005164_abnormal_response_to1.30001186
57MP0001270_distended_abdomen1.29280133
58MP0000778_abnormal_nervous_system1.26607727
59MP0004147_increased_porphyrin_level1.25744333
60MP0001486_abnormal_startle_reflex1.23509208
61MP0001958_emphysema1.22217838
62MP0000569_abnormal_digit_pigmentation1.21537289
63MP0000371_diluted_coat_color1.20674432
64MP0000762_abnormal_tongue_morphology1.20272227
65MP0004957_abnormal_blastocyst_morpholog1.19534291
66MP0000465_gastrointestinal_hemorrhage1.15143465
67MP0002166_altered_tumor_susceptibility1.15032804
68MP0005171_absent_coat_pigmentation1.14940009
69MP0000015_abnormal_ear_pigmentation1.14889491
70MP0001879_abnormal_lymphatic_vessel1.14836908
71MP0002734_abnormal_mechanical_nocicepti1.14195861
72MP0003705_abnormal_hypodermis_morpholog1.13578790
73MP0002972_abnormal_cardiac_muscle1.13471432
74MP0002896_abnormal_bone_mineralization1.08597951
75MP0002161_abnormal_fertility/fecundity1.07916436
76MP0009780_abnormal_chondrocyte_physiolo1.07179019
77MP0004484_altered_response_of1.06983617
78MP0002133_abnormal_respiratory_system1.06464881
79MP0005388_respiratory_system_phenotype1.06464881
80MP0005367_renal/urinary_system_phenotyp1.06263004
81MP0000516_abnormal_urinary_system1.06263004
82MP0003566_abnormal_cell_adhesion1.06256825
83MP0004233_abnormal_muscle_weight1.06221324
84MP0001501_abnormal_sleep_pattern1.04484950
85MP0003755_abnormal_palate_morphology1.03913758
86MP0002006_tumorigenesis1.03253167
87MP0003656_abnormal_erythrocyte_physiolo1.03217542
88MP0009053_abnormal_anal_canal1.02248517
89MP0004742_abnormal_vestibular_system1.01355804
90MP0000678_abnormal_parathyroid_gland1.00589845
91MP0005503_abnormal_tendon_morphology0.99656824
92MP0005195_abnormal_posterior_eye0.98498038
93MP0000733_abnormal_muscle_development0.96777963
94MP0003828_pulmonary_edema0.95638892
95MP0010352_gastrointestinal_tract_polyps0.95346065
96MP0000003_abnormal_adipose_tissue0.94891131
97MP0002837_dystrophic_cardiac_calcinosis0.94869140
98MP0004084_abnormal_cardiac_muscle0.94831747
99MP0010307_abnormal_tumor_latency0.94760537
100MP0005670_abnormal_white_adipose0.93452990
101MP0005023_abnormal_wound_healing0.92893155
102MP0002277_abnormal_respiratory_mucosa0.92203011
103MP0005197_abnormal_uvea_morphology0.90565025
104MP0003878_abnormal_ear_physiology0.90322398
105MP0005377_hearing/vestibular/ear_phenot0.90322398
106MP0003806_abnormal_nucleotide_metabolis0.90300466
107MP0000534_abnormal_ureter_morphology0.88878040
108MP0003631_nervous_system_phenotype0.88834502
109MP0002102_abnormal_ear_morphology0.87933666
110MP0010094_abnormal_chromosome_stability0.87323151
111MP0004883_abnormal_blood_vessel0.87017412
112MP0004947_skin_inflammation0.85728839
113MP0002282_abnormal_trachea_morphology0.85393203
114MP0002177_abnormal_outer_ear0.84125517
115MP0002933_joint_inflammation0.82983754
116MP0001485_abnormal_pinna_reflex0.82963691
117MP0002067_abnormal_sensory_capabilities0.82718828
118MP0003718_maternal_effect0.82650055
119MP0002064_seizures0.82564991
120MP0002090_abnormal_vision0.82412049
121MP0008789_abnormal_olfactory_epithelium0.82023671
122MP0000627_abnormal_mammary_gland0.81972893
123MP0002095_abnormal_skin_pigmentation0.81525903
124MP0005551_abnormal_eye_electrophysiolog0.80092696
125MP0003136_yellow_coat_color0.79826518
126MP0002419_abnormal_innate_immunity0.78941518
127MP0002113_abnormal_skeleton_development0.75361853
128MP0001324_abnormal_eye_pigmentation0.74605073
129MP0000749_muscle_degeneration0.74522335
130MP0004185_abnormal_adipocyte_glucose0.70682279
131MP0003115_abnormal_respiratory_system0.70681329
132MP0001191_abnormal_skin_condition0.70363041
133MP0000163_abnormal_cartilage_morphology0.70165286
134MP0005395_other_phenotype0.69513675
135MP0001915_intracranial_hemorrhage0.68643430
136MP0008057_abnormal_DNA_replication0.68427686
137MP0010678_abnormal_skin_adnexa0.68213604
138MP0009745_abnormal_behavioral_response0.67965333
139MP0002269_muscular_atrophy0.67878477
140MP0005193_abnormal_anterior_eye0.66947832
141MP0006072_abnormal_retinal_apoptosis0.66601726
142MP0001243_abnormal_dermal_layer0.65610713
143MP0001943_abnormal_respiration0.65472136
144MP0001340_abnormal_eyelid_morphology0.65346319
145MP0008007_abnormal_cellular_replicative0.64512178
146MP0002116_abnormal_craniofacial_bone0.64404843
147MP0002115_abnormal_skeleton_extremities0.63269992
148MP0002210_abnormal_sex_determination0.62824822
149MP0000350_abnormal_cell_proliferation0.61361752
150MP0002168_other_aberrant_phenotype0.59924601
151MP0005165_increased_susceptibility_to0.59223123
152MP0001614_abnormal_blood_vessel0.59170294
153MP0005310_abnormal_salivary_gland0.59064216
154MP0005187_abnormal_penis_morphology0.58670301
155MP0000613_abnormal_salivary_gland0.58262170
156MP0002396_abnormal_hematopoietic_system0.57039439
157MP0001186_pigmentation_phenotype0.56863524
158MP0005253_abnormal_eye_physiology0.55253593
159MP0002086_abnormal_extraembryonic_tissu0.54441436
160MP0005621_abnormal_cell_physiology0.54367418
161MP0002925_abnormal_cardiovascular_devel0.54308898
162MP0005375_adipose_tissue_phenotype0.54259012
163MP0002234_abnormal_pharynx_morphology0.53090805
164MP0001697_abnormal_embryo_size0.52915623

Predicted human phenotypes

RankGene SetZ-score
1Urethral obstruction (HP:0000796)5.21706603
2Aplasia involving bones of the upper limbs (HP:0009823)4.93439760
3Aplasia of the phalanges of the hand (HP:0009802)4.93439760
4Aplasia involving bones of the extremities (HP:0009825)4.93439760
5Hydroureter (HP:0000072)4.31584965
6Severe visual impairment (HP:0001141)4.21334966
7Submucous cleft hard palate (HP:0000176)4.16864864
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.13047314
9Absent/shortened dynein arms (HP:0200106)4.13047314
10Abnormal tarsal ossification (HP:0008369)3.98034325
11Tubulointerstitial nephritis (HP:0001970)3.96438829
12Abnormal foot bone ossification (HP:0010675)3.93697393
13Male infertility (HP:0003251)3.89102474
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.86519346
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.86519346
16Bell-shaped thorax (HP:0001591)3.71933949
17Abnormal respiratory motile cilium morphology (HP:0005938)3.57871148
18Abnormal respiratory epithelium morphology (HP:0012253)3.57871148
19Nasal polyposis (HP:0100582)3.56067417
20Cupped ribs (HP:0000887)3.53740207
21Asymmetric septal hypertrophy (HP:0001670)3.39990883
22Scanning speech (HP:0002168)3.34395221
23Arterial tortuosity (HP:0005116)3.31236358
24Hyperkalemia (HP:0002153)3.29528094
25Atrophic scars (HP:0001075)3.28525439
26Mediastinal lymphadenopathy (HP:0100721)3.24480038
27Abnormal auditory evoked potentials (HP:0006958)3.21888383
28Upper limb muscle weakness (HP:0003484)3.19042910
29Thoracolumbar scoliosis (HP:0002944)3.14027353
30Hypoplastic ischia (HP:0003175)3.13955593
31Abnormality of the ischium (HP:0003174)3.05774642
32Vascular tortuosity (HP:0004948)2.97702159
33Insidious onset (HP:0003587)2.93045177
34Termporal pattern (HP:0011008)2.93045177
35Resting tremor (HP:0002322)2.92418880
36Popliteal pterygium (HP:0009756)2.90609466
37Abnormality of macular pigmentation (HP:0008002)2.85627291
38Chronic hepatic failure (HP:0100626)2.85508016
39Flat acetabular roof (HP:0003180)2.83864495
40Cone-rod dystrophy (HP:0000548)2.83286706
41Bowel incontinence (HP:0002607)2.83257620
42Abnormality of the nasal mucosa (HP:0000433)2.81341426
43Infertility (HP:0000789)2.76585310
44Entropion (HP:0000621)2.75952199
45Abnormal ciliary motility (HP:0012262)2.70894185
46Abnormal respiratory motile cilium physiology (HP:0012261)2.67769426
47Sensorimotor neuropathy (HP:0007141)2.65697837
48Median cleft lip (HP:0000161)2.65309591
49Abnormal large intestine physiology (HP:0012700)2.65241700
50Spondylolisthesis (HP:0003302)2.63478306
51Stomach cancer (HP:0012126)2.60007392
52Abnormality of incisor morphology (HP:0011063)2.50963319
53Abnormality of placental membranes (HP:0011409)2.48624774
54Amniotic constriction ring (HP:0009775)2.48624774
55Sensory axonal neuropathy (HP:0003390)2.43658515
56Progressive sensorineural hearing impairment (HP:0000408)2.41851740
57Genetic anticipation (HP:0003743)2.41140614
58Patchy hypopigmentation of hair (HP:0011365)2.39660164
59Distal lower limb muscle weakness (HP:0009053)2.37474952
60Abnormality of carpal bone ossification (HP:0006257)2.34484443
61Rhinitis (HP:0012384)2.33935484
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.33853963
63Aortic aneurysm (HP:0004942)2.32266010
64Abnormal hair whorl (HP:0010721)2.28978995
65Lower limb amyotrophy (HP:0007210)2.28492031
66Myocardial infarction (HP:0001658)2.28101064
67Distal lower limb amyotrophy (HP:0008944)2.27342970
68Urinary bladder sphincter dysfunction (HP:0002839)2.25697157
69Chin dimple (HP:0010751)2.25063656
70Premature rupture of membranes (HP:0001788)2.25038916
71Dysmetric saccades (HP:0000641)2.24751462
72White forelock (HP:0002211)2.24553826
73Aplasia/Hypoplasia of the earlobes (HP:0009906)2.24074122
74Bronchiectasis (HP:0002110)2.22091689
75Abnormality of the acetabulum (HP:0003170)2.20841684
76Scapular winging (HP:0003691)2.19101329
77Unilateral renal agenesis (HP:0000122)2.15434817
78Stillbirth (HP:0003826)2.14981027
79Tarsal synostosis (HP:0008368)2.14674040
80Bony spicule pigmentary retinopathy (HP:0007737)2.12394702
81Orthostatic hypotension (HP:0001278)2.11039897
82Menstrual irregularities (HP:0000858)2.10438694
83Soft skin (HP:0000977)2.10423897
84Fatigue (HP:0012378)2.10171211
85Abnormality of the corticospinal tract (HP:0002492)2.08522392
86Megalencephaly (HP:0001355)2.08316083
87Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07723987
88Attenuation of retinal blood vessels (HP:0007843)2.06793424
89Protrusio acetabuli (HP:0003179)2.06157629
90Bradycardia (HP:0001662)2.05804807
91Progressive hearing impairment (HP:0001730)2.03412323
92Short nail (HP:0001799)2.02129048
93Chronic sinusitis (HP:0011109)2.02079365
94Synostosis involving bones of the feet (HP:0009140)2.01997553
95Synostosis involving bones of the lower limbs (HP:0009138)2.01997553
96Glucose intolerance (HP:0000833)2.00677445
97Abnormal spermatogenesis (HP:0008669)1.99661343
98Hypoplasia of the iris (HP:0007676)1.99051668
99Neonatal short-limb short stature (HP:0008921)1.97584124
100Exercise-induced muscle cramps (HP:0003710)1.96426492
101Lip pit (HP:0100267)1.93678388
102Small epiphyses (HP:0010585)1.93141669
103Omphalocele (HP:0001539)1.89761571
104Chorioretinal atrophy (HP:0000533)1.88877468
105Rhizomelia (HP:0008905)1.88874520
106Femoral bowing (HP:0002980)1.86627344
107Fibular hypoplasia (HP:0003038)1.86236721
108Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85426267
109Aplasia/Hypoplasia of the macula (HP:0008059)1.85356426
110Flattened epiphyses (HP:0003071)1.85273691
111Xerostomia (HP:0000217)1.84995843
112Horizontal nystagmus (HP:0000666)1.84977057
113Progressive cerebellar ataxia (HP:0002073)1.84911186
114Volvulus (HP:0002580)1.84520391
115Abnormal platelet volume (HP:0011876)1.83840216
116Epileptic encephalopathy (HP:0200134)1.83497508
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.83275841
118Inflammation of the large intestine (HP:0002037)1.82643545
119Ocular albinism (HP:0001107)1.82041986
120Metaphyseal irregularity (HP:0003025)1.81692861
121Hypopigmentation of the fundus (HP:0007894)1.81679009
122Recurrent corneal erosions (HP:0000495)1.79783308
123Freckling (HP:0001480)1.77732308
124Supranuclear gaze palsy (HP:0000605)1.77161981
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76886680
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76526249
127Steppage gait (HP:0003376)1.76477127
128Mask-like facies (HP:0000298)1.75626064
129Autoamputation (HP:0001218)1.75597237
130Facial cleft (HP:0002006)1.75398702
131Increased corneal curvature (HP:0100692)1.74525447
132Keratoconus (HP:0000563)1.74525447
133Intellectual disability, moderate (HP:0002342)1.73477267
134Hypophosphatemic rickets (HP:0004912)1.73303240
135Convex nasal ridge (HP:0000444)1.73270953
136Ulnar bowing (HP:0003031)1.73123910
137Absent frontal sinuses (HP:0002688)1.72203216
138Lower limb muscle weakness (HP:0007340)1.72091677
139Abnormal gallbladder physiology (HP:0012438)1.71974043
140Cholecystitis (HP:0001082)1.71974043
141Deep philtrum (HP:0002002)1.71191778
142Aplasia/Hypoplasia of the fibula (HP:0006492)1.70722526
143Enlarged epiphyses (HP:0010580)1.69484669
144Abnormal ossification of hand bones (HP:0005921)1.69048964
145Mixed hearing impairment (HP:0000410)1.68400508
146Urinary urgency (HP:0000012)1.67251609
147Increased mean platelet volume (HP:0011877)1.67027318
148Cellulitis (HP:0100658)1.66631924
149Akinesia (HP:0002304)1.65969448
150Bifid uvula (HP:0000193)1.65780370
151Intestinal malrotation (HP:0002566)1.65452748
152Ankyloglossia (HP:0010296)1.65374335
153Epiphyseal dysplasia (HP:0002656)1.64750194
154Increased cerebral lipofuscin (HP:0011813)1.64350840
155Abnormality of the parathyroid morphology (HP:0011766)1.64192034
156Aplasia/Hypoplasia of the scapulae (HP:0006713)1.63919897
157Hypoplastic scapulae (HP:0000882)1.63919897
158Abnormality of dentin (HP:0010299)1.63906134
159Short ribs (HP:0000773)1.63632488
160Tubulointerstitial abnormality (HP:0001969)1.62998998
161Focal segmental glomerulosclerosis (HP:0000097)1.62687390
162Truncal obesity (HP:0001956)1.62683274
163Aortic dissection (HP:0002647)1.62298925
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.61663274
165Fatigable weakness (HP:0003473)1.59678932
166Abnormality of the neuromuscular junction (HP:0003398)1.59678932
167Aplasia/Hypoplasia affecting the retina (HP:0008061)1.59411238
168Vertebral clefting (HP:0008428)1.59203008
169Impaired vibration sensation in the lower limbs (HP:0002166)1.57884012
170Sandal gap (HP:0001852)1.57796816
171Cupped ear (HP:0000378)1.57771228
172Abnormality of the frontal sinuses (HP:0002687)1.57657420
173Abnormal hand bone ossification (HP:0010660)1.57008477
174Toxemia of pregnancy (HP:0100603)1.55207977
175Decreased motor nerve conduction velocity (HP:0003431)1.55016631
176Down-sloping shoulders (HP:0200021)1.54974413
177Dilatation of the ascending aorta (HP:0005111)1.54762413
178Abnormality of oral frenula (HP:0000190)1.53888271
179Slow saccadic eye movements (HP:0000514)1.53199133
180Abnormality of the fibula (HP:0002991)1.53080735
181Spontaneous hematomas (HP:0007420)1.51778341
182Osteolytic defects of the hand bones (HP:0009699)1.50408606
183Osteolytic defects of the phalanges of the hand (HP:0009771)1.50408606
184Verrucae (HP:0200043)1.49083125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.07333298
2PLK45.68564865
3MST1R3.99595375
4DDR23.49312361
5BRD43.16643023
6PBK3.11172581
7TESK12.90718669
8STK38L2.76026217
9EPHB12.73269981
10TNK22.62798346
11EIF2AK32.61091674
12STK382.50268314
13EIF2AK12.45517626
14PNCK2.42652406
15IRAK42.40568551
16LATS22.31187237
17CASK2.14701754
18MAP3K102.12433391
19STK392.08870334
20MST42.07434542
21HIPK22.04619433
22LATS12.04145373
23FGFR22.01694407
24ERBB31.97571453
25WEE11.92476028
26PRKD31.89870404
27TLK11.79857713
28MAP4K21.76124399
29MELK1.61162830
30NEK91.61114181
31PRPF4B1.49540762
32MAPK151.47503883
33STK101.45712490
34IRAK31.45575794
35NUAK11.44454472
36WNK11.43444678
37AKT31.42165766
38PRKCH1.41065139
39INSRR1.40016187
40CLK11.39157420
41BRSK21.35337572
42CSNK1A1L1.34413533
43UHMK11.29416729
44LIMK11.29398691
45PKN21.28453152
46TRPM71.25087503
47CSNK1G11.24046241
48PDK21.22632472
49JAK11.20016516
50OXSR11.19749539
51ERBB41.18240195
52CSNK1G31.16448345
53FES1.11981302
54JAK31.05560029
55FER1.03910090
56SGK2231.03340633
57SGK4941.03340633
58CDK121.01699601
59LMTK21.01577407
60WNK41.00686296
61CSNK1G20.99164151
62PRKD20.98733219
63CDK60.98609193
64CDK70.98334426
65MAP3K140.97961982
66MAP2K30.96530802
67PLK30.96490853
68ITK0.95856232
69NEK20.94401954
70MAP3K120.93765037
71TRIM280.92915566
72TGFBR20.91494011
73MYLK0.90729260
74PLK20.90313487
75MAP3K90.87060325
76STK30.86369268
77PAK40.86061302
78MAP3K20.85554941
79TTN0.85035608
80PIK3CG0.84413104
81SCYL20.82623819
82PAK20.82330739
83SGK20.81587926
84CAMK1G0.81083101
85PDGFRA0.79348345
86MOS0.79301141
87MAP3K130.75926661
88TNIK0.75770902
89SRPK10.71346479
90MAP4K10.70713640
91BMPR1B0.70398563
92FGFR30.69701440
93TEC0.68802768
94SIK20.68243202
95SGK10.65664533
96BCR0.65237463
97CDK30.64553022
98KSR20.63905341
99PAK30.62594370
100CDK80.61632330
101YES10.61444128
102NEK60.60662801
103BMX0.60090864
104ARAF0.58996346
105PDGFRB0.58906845
106BTK0.58480572
107TYK20.58432889
108PRKCE0.56844610
109JAK20.56589575
110GSK3A0.54753838
111FGR0.54316080
112FYN0.54088083
113MET0.53565295
114IRAK10.53512001
115PDPK10.53491985
116DYRK1A0.52485453
117MARK30.52468387
118FGFR10.52384129
119PDK10.52109925
120PRKCQ0.51560207
121CSK0.51135059
122HCK0.51006090
123INSR0.50081470
124ROCK20.49978534
125TIE10.48959721
126CAMK1D0.48435018
127LCK0.48412362
128MKNK20.48324359
129CAMK2D0.48244342
130RET0.46975207
131PIK3CA0.46857123
132GRK60.46597250
133BMPR20.46447152
134PTK60.45388124
135ALK0.44536845
136CSF1R0.44206261
137PRKAA20.43881924
138EGFR0.43696701
139SRC0.42782616
140CDK140.42178718
141CAMK2B0.42010072
142MAPKAPK20.41992461
143PTK2B0.41460759
144EPHA20.41036055
145EPHA30.40706269
146CDK180.40394608
147IGF1R0.40228515
148MAP3K80.38945404
149BRAF0.37031507
150ROCK10.36016890
151CHEK10.34850310
152MTOR0.33324737
153ATM0.33265318
154SIK30.32862520
155PLK10.31050734
156TTK0.30275401
157BRSK10.28527628
158CDK90.25238653
159MAP2K10.23587520
160CDK10.23287434
161WNK30.22490083
162CDK20.21590445
163RPS6KA40.19796820
164MAPK10.19433763
165NEK10.18556881

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.25337716
2Fatty acid biosynthesis_Homo sapiens_hsa000612.95942348
3Non-homologous end-joining_Homo sapiens_hsa034502.29014350
4ABC transporters_Homo sapiens_hsa020102.10531358
5Graft-versus-host disease_Homo sapiens_hsa053322.08244756
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91686065
7Malaria_Homo sapiens_hsa051441.88405129
8Sulfur metabolism_Homo sapiens_hsa009201.86464040
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84988359
10RNA transport_Homo sapiens_hsa030131.81314584
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.79986821
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.78604804
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.71596132
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56714848
15Small cell lung cancer_Homo sapiens_hsa052221.48440255
16Prion diseases_Homo sapiens_hsa050201.48250871
17Pertussis_Homo sapiens_hsa051331.47006293
18Renal cell carcinoma_Homo sapiens_hsa052111.45769565
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45556799
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.41220215
21Thyroid cancer_Homo sapiens_hsa052161.41152409
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37911804
23Phagosome_Homo sapiens_hsa041451.36254107
24Proteoglycans in cancer_Homo sapiens_hsa052051.35182830
25Legionellosis_Homo sapiens_hsa051341.34735529
26African trypanosomiasis_Homo sapiens_hsa051431.31205268
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26756524
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26051434
29Fatty acid metabolism_Homo sapiens_hsa012121.22936886
30Axon guidance_Homo sapiens_hsa043601.22629091
31Osteoclast differentiation_Homo sapiens_hsa043801.19117618
32B cell receptor signaling pathway_Homo sapiens_hsa046621.18424114
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15743848
34Hematopoietic cell lineage_Homo sapiens_hsa046401.15733900
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15328268
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15220015
37Influenza A_Homo sapiens_hsa051641.15013945
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14599205
39p53 signaling pathway_Homo sapiens_hsa041151.12910022
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11836402
41Salmonella infection_Homo sapiens_hsa051321.09781999
42Renin secretion_Homo sapiens_hsa049241.09732923
43Chemokine signaling pathway_Homo sapiens_hsa040621.09591831
44Cell cycle_Homo sapiens_hsa041101.08892359
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08282016
46Basal transcription factors_Homo sapiens_hsa030221.08006997
47Hepatitis B_Homo sapiens_hsa051611.06789045
48Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06063480
49Leishmaniasis_Homo sapiens_hsa051401.04452609
50Butanoate metabolism_Homo sapiens_hsa006501.04440029
51Nucleotide excision repair_Homo sapiens_hsa034201.04038848
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03893239
53Focal adhesion_Homo sapiens_hsa045101.02832330
54mRNA surveillance pathway_Homo sapiens_hsa030151.02792581
55Tuberculosis_Homo sapiens_hsa051521.01834938
56Shigellosis_Homo sapiens_hsa051311.00679786
57Endometrial cancer_Homo sapiens_hsa052130.99967335
58MicroRNAs in cancer_Homo sapiens_hsa052060.97793925
59Chronic myeloid leukemia_Homo sapiens_hsa052200.96578562
60Measles_Homo sapiens_hsa051620.96443194
61Toxoplasmosis_Homo sapiens_hsa051450.96267841
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94948995
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94806265
64TGF-beta signaling pathway_Homo sapiens_hsa043500.93178792
65Fructose and mannose metabolism_Homo sapiens_hsa000510.92180832
66Dilated cardiomyopathy_Homo sapiens_hsa054140.92108736
67T cell receptor signaling pathway_Homo sapiens_hsa046600.91260736
68Morphine addiction_Homo sapiens_hsa050320.90315334
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90299044
70ErbB signaling pathway_Homo sapiens_hsa040120.89031850
71Glioma_Homo sapiens_hsa052140.88834872
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88567920
73Gastric acid secretion_Homo sapiens_hsa049710.88464145
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87800169
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87697239
76Non-small cell lung cancer_Homo sapiens_hsa052230.86477424
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.86268657
78Cholinergic synapse_Homo sapiens_hsa047250.83960143
79GABAergic synapse_Homo sapiens_hsa047270.82862660
80Inositol phosphate metabolism_Homo sapiens_hsa005620.82447797
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81288537
82Nitrogen metabolism_Homo sapiens_hsa009100.80448030
83Phototransduction_Homo sapiens_hsa047440.79764404
84Tight junction_Homo sapiens_hsa045300.78803504
85Pentose phosphate pathway_Homo sapiens_hsa000300.78588133
86Primary immunodeficiency_Homo sapiens_hsa053400.78155948
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.78003168
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77850626
89Platelet activation_Homo sapiens_hsa046110.77136706
90Prostate cancer_Homo sapiens_hsa052150.76455915
91MAPK signaling pathway_Homo sapiens_hsa040100.75918015
92Fatty acid elongation_Homo sapiens_hsa000620.74936955
93Rheumatoid arthritis_Homo sapiens_hsa053230.74435766
94Dorso-ventral axis formation_Homo sapiens_hsa043200.73989180
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.73734300
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.73560350
97Herpes simplex infection_Homo sapiens_hsa051680.73250754
98Protein export_Homo sapiens_hsa030600.73230473
99Mismatch repair_Homo sapiens_hsa034300.72945106
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72651951
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72030750
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71560938
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71041750
104Amoebiasis_Homo sapiens_hsa051460.70665329
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70515704
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70039939
107Viral carcinogenesis_Homo sapiens_hsa052030.69448771
108Circadian entrainment_Homo sapiens_hsa047130.69267400
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.68838566
110Viral myocarditis_Homo sapiens_hsa054160.68688154
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68676475
112Circadian rhythm_Homo sapiens_hsa047100.68187506
113Melanoma_Homo sapiens_hsa052180.68102942
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67773313
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67542632
116Protein digestion and absorption_Homo sapiens_hsa049740.66489218
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.65416360
118FoxO signaling pathway_Homo sapiens_hsa040680.65360347
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64328723
120Dopaminergic synapse_Homo sapiens_hsa047280.63182404
121Colorectal cancer_Homo sapiens_hsa052100.62846059
122Hepatitis C_Homo sapiens_hsa051600.62557200
123N-Glycan biosynthesis_Homo sapiens_hsa005100.62244495
124Adherens junction_Homo sapiens_hsa045200.62045354
125TNF signaling pathway_Homo sapiens_hsa046680.61984404
126Oocyte meiosis_Homo sapiens_hsa041140.61355578
127Endocytosis_Homo sapiens_hsa041440.60458357
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60247835
129Pancreatic cancer_Homo sapiens_hsa052120.59826636
130Sphingolipid metabolism_Homo sapiens_hsa006000.59544675
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59326124
132Rap1 signaling pathway_Homo sapiens_hsa040150.57358094
133ECM-receptor interaction_Homo sapiens_hsa045120.57066105
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56650179
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56387156
136Pathways in cancer_Homo sapiens_hsa052000.55740266
137Serotonergic synapse_Homo sapiens_hsa047260.55708747
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55433506
139Cocaine addiction_Homo sapiens_hsa050300.54335599
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54215382
141Oxytocin signaling pathway_Homo sapiens_hsa049210.53910318
142Olfactory transduction_Homo sapiens_hsa047400.53076783
143Bladder cancer_Homo sapiens_hsa052190.52989311
144Hippo signaling pathway_Homo sapiens_hsa043900.52664695
145HIF-1 signaling pathway_Homo sapiens_hsa040660.52560674
146Biosynthesis of amino acids_Homo sapiens_hsa012300.51297753
147Carbon metabolism_Homo sapiens_hsa012000.51105535
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48731159
149Type II diabetes mellitus_Homo sapiens_hsa049300.48437665
150Acute myeloid leukemia_Homo sapiens_hsa052210.47861246
151One carbon pool by folate_Homo sapiens_hsa006700.46957379
152Fanconi anemia pathway_Homo sapiens_hsa034600.46921939
153Apoptosis_Homo sapiens_hsa042100.45425940
154Steroid biosynthesis_Homo sapiens_hsa001000.45356191
155Tyrosine metabolism_Homo sapiens_hsa003500.44677226
156Galactose metabolism_Homo sapiens_hsa000520.44457279
157Insulin resistance_Homo sapiens_hsa049310.41326084
158Epstein-Barr virus infection_Homo sapiens_hsa051690.40496800

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