JUND

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)5.04846385
2regulation of gamma-delta T cell differentiation (GO:0045586)4.89461390
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55585732
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55585732
5antigen processing and presentation of endogenous antigen (GO:0019883)4.51232794
6regulation of gamma-delta T cell activation (GO:0046643)4.37974557
7endothelial cell chemotaxis (GO:0035767)4.36963868
8tolerance induction (GO:0002507)4.27380442
9positive regulation of gamma-delta T cell activation (GO:0046645)4.21690627
10thymic T cell selection (GO:0045061)4.04152167
11negative regulation of erythrocyte differentiation (GO:0045647)3.98694354
12positive regulation of histone deacetylation (GO:0031065)3.97843499
13positive T cell selection (GO:0043368)3.93727658
14negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.83373453
15JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.81948866
16response to laminar fluid shear stress (GO:0034616)3.77677002
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.73729084
18T cell selection (GO:0045058)3.51727388
19mannose metabolic process (GO:0006013)3.49591419
20protein localization to endosome (GO:0036010)3.48069572
21regulation of p38MAPK cascade (GO:1900744)3.29584908
22negative regulation of cAMP-mediated signaling (GO:0043951)3.24909251
23natural killer cell differentiation (GO:0001779)3.19812274
24response to muramyl dipeptide (GO:0032495)3.19264763
25positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.16270269
26positive regulation of Rap GTPase activity (GO:0032854)3.14204824
27negative thymic T cell selection (GO:0045060)3.13665170
28response to interleukin-15 (GO:0070672)3.13334757
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09495761
30negative regulation of cell killing (GO:0031342)3.09495761
31negative T cell selection (GO:0043383)3.09114495
32positive regulation of p38MAPK cascade (GO:1900745)3.03811680
33negative regulation of bone resorption (GO:0045779)2.99484408
34NIK/NF-kappaB signaling (GO:0038061)2.94609655
35cell migration involved in sprouting angiogenesis (GO:0002042)2.88885558
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88615643
37growth hormone receptor signaling pathway (GO:0060396)2.87356914
38germ cell migration (GO:0008354)2.80480340
39hepatocyte apoptotic process (GO:0097284)2.79151312
40regulation of T cell tolerance induction (GO:0002664)2.78824994
41regulation of extracellular matrix disassembly (GO:0010715)2.78253826
42positive regulation of protein deacetylation (GO:0090312)2.67455622
43activated T cell proliferation (GO:0050798)2.66589351
44entrainment of circadian clock by photoperiod (GO:0043153)2.63929673
45receptor catabolic process (GO:0032801)2.63059717
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62996323
47negative regulation of fatty acid transport (GO:2000192)2.62711711
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60521287
49positive regulation of extracellular matrix organization (GO:1903055)2.60411446
50cytoskeletal anchoring at plasma membrane (GO:0007016)2.60252536
51negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.58467883
52stress fiber assembly (GO:0043149)2.56989274
533-UTR-mediated mRNA stabilization (GO:0070935)2.56975668
54cortical actin cytoskeleton organization (GO:0030866)2.56256581
55negative regulation of glial cell proliferation (GO:0060253)2.55194081
56response to fluid shear stress (GO:0034405)2.54547191
57regulation of Rap GTPase activity (GO:0032317)2.54372090
58B cell homeostasis (GO:0001782)2.53902464
59Peyers patch development (GO:0048541)2.53466460
60mucosal-associated lymphoid tissue development (GO:0048537)2.53466460
61positive regulation of tolerance induction (GO:0002645)2.52238793
62regulation of cholesterol homeostasis (GO:2000188)2.49329658
63negative regulation of granulocyte differentiation (GO:0030853)2.49101602
64RNA destabilization (GO:0050779)2.48886714
65CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.48845828
66cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48037596
67leukocyte aggregation (GO:0070486)2.47228048
68T cell receptor signaling pathway (GO:0050852)2.45195818
69histone H3 deacetylation (GO:0070932)2.44981076
70germinal center formation (GO:0002467)2.43837860
71regulation of B cell receptor signaling pathway (GO:0050855)2.43156695
72cellular response to growth hormone stimulus (GO:0071378)2.41409898
73interferon-gamma production (GO:0032609)2.41392361
74T cell migration (GO:0072678)2.41294672
75positive regulation of CREB transcription factor activity (GO:0032793)2.40725153
76blood vessel endothelial cell migration (GO:0043534)2.39390215
77B cell receptor signaling pathway (GO:0050853)2.39301553
78regulation of erythrocyte differentiation (GO:0045646)2.39026231
79negative regulation of toll-like receptor signaling pathway (GO:0034122)2.38765676
80platelet-derived growth factor receptor signaling pathway (GO:0048008)2.38239603
81negative regulation of bone remodeling (GO:0046851)2.38080157
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37672005
83regulation of ARF protein signal transduction (GO:0032012)2.37463730
84endothelial tube morphogenesis (GO:0061154)2.35483422
85morphogenesis of an endothelium (GO:0003159)2.35483422
86embryonic process involved in female pregnancy (GO:0060136)2.35364590
87regulation of germinal center formation (GO:0002634)2.33908060
88maternal placenta development (GO:0001893)2.33245549
89T cell costimulation (GO:0031295)2.32775120
90positive regulation of B cell differentiation (GO:0045579)2.32670848
91regulation of monocyte differentiation (GO:0045655)2.32591315
92leukocyte cell-cell adhesion (GO:0007159)2.31917590
93positive regulation of granulocyte differentiation (GO:0030854)2.29520960
94cellular response to interleukin-15 (GO:0071350)2.28777379
95negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27592611
96T-helper cell differentiation (GO:0042093)2.26367456
97CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.26367456
98myeloid dendritic cell differentiation (GO:0043011)2.26176473
99antigen receptor-mediated signaling pathway (GO:0050851)2.26033919
100regulation of ARF GTPase activity (GO:0032312)2.26013044
101negative regulation of inclusion body assembly (GO:0090084)2.25700385
102negative regulation of interleukin-8 production (GO:0032717)2.25596625
103lymphocyte costimulation (GO:0031294)2.25456361
104regulation of granulocyte differentiation (GO:0030852)2.25401125
105establishment of endothelial barrier (GO:0061028)2.25095060
106hemidesmosome assembly (GO:0031581)2.24910674
107cell-cell junction maintenance (GO:0045217)2.24682694
108modulation by virus of host process (GO:0019054)2.24625832
109activation of JUN kinase activity (GO:0007257)2.24134157
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23923357
111erythrocyte maturation (GO:0043249)2.23827391
112negative regulation of interleukin-6 production (GO:0032715)2.23768241
113cellular response to fluid shear stress (GO:0071498)2.23570269
114regulation of histone deacetylation (GO:0031063)2.22685397
115megakaryocyte development (GO:0035855)2.22615952
116macrophage activation involved in immune response (GO:0002281)2.22389417
117skin morphogenesis (GO:0043589)2.22222361
118positive regulation by symbiont of host defense response (GO:0052509)2.22145148
119modulation by symbiont of host defense response (GO:0052031)2.22145148
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22145148
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22145148
122positive regulation by organism of defense response of other organism involved in symbiotic interact2.22145148
123modulation by symbiont of host immune response (GO:0052553)2.22145148
124activation of MAPKKK activity (GO:0000185)2.21404541
125response to corticosterone (GO:0051412)2.21199947
126cellular extravasation (GO:0045123)2.21154298
127regulation of extracellular matrix organization (GO:1903053)2.21019981
128regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.20896015
129regulation of type I interferon-mediated signaling pathway (GO:0060338)2.20703882
130regulation of B cell differentiation (GO:0045577)2.19888700
131angiogenesis involved in wound healing (GO:0060055)2.19532435
132negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.19461526
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.17463063
134CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.17111087
135peptidyl-tyrosine autophosphorylation (GO:0038083)2.16633456
136alpha-beta T cell differentiation (GO:0046632)2.14759071
137regulation of cytokine production involved in inflammatory response (GO:1900015)2.14752772
138regulation of interleukin-4 production (GO:0032673)2.14194683
139negative regulation of interleukin-2 production (GO:0032703)2.13177264
140positive regulation of T cell differentiation in thymus (GO:0033089)2.12436562
141defense response to protozoan (GO:0042832)2.09638761
142regulation of T-helper 2 cell differentiation (GO:0045628)2.07655985
143response to protozoan (GO:0001562)2.05706097
144negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.05301960
145regulation of histone H3-K27 methylation (GO:0061085)2.04977171
146negative regulation of innate immune response (GO:0045824)2.04955249
147positive regulation by host of viral transcription (GO:0043923)2.03694098
148positive regulation of alpha-beta T cell differentiation (GO:0046638)2.03651938
149lymphocyte homeostasis (GO:0002260)2.03251182
150heart valve formation (GO:0003188)2.02307599
151negative regulation of leukocyte mediated immunity (GO:0002704)2.02105950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77539358
2MYC_22102868_ChIP-Seq_BL_Human3.35097029
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.19121832
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19107336
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.97179173
6* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.92838479
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.83778914
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.71252745
9* KDM2B_26808549_Chip-Seq_DND41_Human2.65201463
10VDR_21846776_ChIP-Seq_THP-1_Human2.63145322
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.62996763
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46767452
13* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.38011531
14* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36876335
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.35944632
16* MAF_26560356_Chip-Seq_TH1_Human2.19060646
17SCL_19346495_ChIP-Seq_HPC-7_Human2.11850338
18RUNX_20019798_ChIP-Seq_JUKART_Human2.05892497
19* LXR_22292898_ChIP-Seq_THP-1_Human2.03599114
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99093056
21UTX_26944678_Chip-Seq_JUKART_Human1.91404296
22VDR_24763502_ChIP-Seq_THP-1_Human1.90983202
23* KDM2B_26808549_Chip-Seq_JURKAT_Human1.90361350
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.89461171
25KDM2B_26808549_Chip-Seq_K562_Human1.87442740
26CLOCK_20551151_ChIP-Seq_293T_Human1.86965002
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82516951
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80184790
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79182658
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.76796673
31RACK7_27058665_Chip-Seq_MCF-7_Human1.75490168
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75347169
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.71300467
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.70470966
35GATA1_19941826_ChIP-Seq_K562_Human1.68085343
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66638455
37ZNF263_19887448_ChIP-Seq_K562_Human1.66398711
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64944931
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.63176313
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62710520
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62492370
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58312934
43DROSHA_22980978_ChIP-Seq_HELA_Human1.57448894
44* MYB_26560356_Chip-Seq_TH2_Human1.54728535
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51456923
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50841073
47* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50057352
48* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49589188
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.47033810
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.46744078
51* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44632843
52* P68_20966046_ChIP-Seq_HELA_Human1.42916676
53* MYB_26560356_Chip-Seq_TH1_Human1.42019098
54MAF_26560356_Chip-Seq_TH2_Human1.41220968
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41078337
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40564448
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39899580
58* RUNX1_22412390_ChIP-Seq_EML_Mouse1.38014113
59FOXO3_23340844_ChIP-Seq_DLD1_Human1.36325581
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35446412
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.34708283
62NCOR1_26117541_ChIP-Seq_K562_Human1.34694708
63SPI1_23127762_ChIP-Seq_K562_Human1.33789361
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33436915
65ESR1_21235772_ChIP-Seq_MCF-7_Human1.31853996
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31754744
67* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31366692
68* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31247544
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31174618
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30734777
71CTCF_27219007_Chip-Seq_Bcells_Human1.30440153
72HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29924399
73* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29506959
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29141144
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26498974
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26422333
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24867493
78CREB1_26743006_Chip-Seq_LNCaP_Human1.23821490
79* ATF3_27146783_Chip-Seq_COLON_Human1.23088970
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22950541
81* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22599654
82* ELF1_20517297_ChIP-Seq_JURKAT_Human1.21896416
83GATA2_19941826_ChIP-Seq_K562_Human1.20699542
84* RARB_27405468_Chip-Seq_BRAIN_Mouse1.19445411
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.19082418
86RNF2_27304074_Chip-Seq_ESCs_Mouse1.18519908
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17254952
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16999271
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.16753586
90SMC4_20622854_ChIP-Seq_HELA_Human1.16402048
91* TET1_21451524_ChIP-Seq_MESCs_Mouse1.15271863
92* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14114161
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13783108
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.13383953
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12142060
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.12020838
97* BCOR_27268052_Chip-Seq_Bcells_Human1.11549503
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11280778
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11262272
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.10276749
101* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10066242
102* BCL6_27268052_Chip-Seq_Bcells_Human1.08471412
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07806573
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05742827
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05186810
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04601668
107* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03868462
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02761981
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02734494
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02509891
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01963524
112* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01902030
113* UBF1/2_26484160_Chip-Seq_HMECs_Human1.01872320
114* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00754773
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99826672
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.98527830
117EZH2_22144423_ChIP-Seq_EOC_Human0.97980370
118* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97592353
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97351328
120GATA2_21666600_ChIP-Seq_HMVEC_Human0.97068339
121SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96676281
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95718331
123EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95718331
124GATA3_27048872_Chip-Seq_THYMUS_Human0.95631074
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94987414
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93718483
127VDR_24787735_ChIP-Seq_THP-1_Human0.93541926
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92861222
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92792903
130* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91158272
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.90662235
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.90662235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.86039207
2MP0003300_gastrointestinal_ulcer3.52048287
3MP0004510_myositis3.20256326
4MP0000685_abnormal_immune_system2.97518379
5MP0009278_abnormal_bone_marrow2.54106200
6MP0002009_preneoplasia2.45300570
7MP0008961_abnormal_basal_metabolism2.45276518
8MP0005387_immune_system_phenotype2.41191089
9MP0001790_abnormal_immune_system2.41191089
10MP0005076_abnormal_cell_differentiation2.32641885
11MP0003763_abnormal_thymus_physiology2.30158487
12MP0004947_skin_inflammation2.18224677
13MP0003436_decreased_susceptibility_to2.16608873
14MP0003705_abnormal_hypodermis_morpholog2.15146682
15MP0001501_abnormal_sleep_pattern2.15065736
16MP0001800_abnormal_humoral_immune2.14947872
17MP0001502_abnormal_circadian_rhythm2.03622099
18MP0005671_abnormal_response_to1.96987499
19MP0003866_abnormal_defecation1.96352460
20MP0005000_abnormal_immune_tolerance1.96019542
21MP0006082_CNS_inflammation1.93753301
22MP0010234_abnormal_vibrissa_follicle1.90368996
23MP0002405_respiratory_system_inflammati1.89801533
24MP0010155_abnormal_intestine_physiology1.89354543
25MP0002452_abnormal_antigen_presenting1.85608380
26MP0002822_catalepsy1.84270493
27MP0003453_abnormal_keratinocyte_physiol1.83667027
28MP0001873_stomach_inflammation1.81140894
29MP0002723_abnormal_immune_serum1.80446075
30MP0001835_abnormal_antigen_presentation1.80311541
31MP0003566_abnormal_cell_adhesion1.79809969
32MP0002138_abnormal_hepatobiliary_system1.78398333
33MP0001851_eye_inflammation1.78386177
34MP0003724_increased_susceptibility_to1.77101293
35MP0003191_abnormal_cellular_cholesterol1.75929897
36MP0010352_gastrointestinal_tract_polyps1.73745875
37MP0002166_altered_tumor_susceptibility1.69215599
38* MP0002420_abnormal_adaptive_immunity1.68140611
39* MP0001819_abnormal_immune_cell1.67255643
40MP0003045_fibrosis1.58588865
41* MP0002398_abnormal_bone_marrow1.55512076
42MP0002249_abnormal_larynx_morphology1.47223969
43MP0002254_reproductive_system_inflammat1.45595243
44MP0005310_abnormal_salivary_gland1.45089413
45MP0004859_abnormal_synaptic_plasticity1.43572736
46MP0005464_abnormal_platelet_physiology1.41301159
47* MP0000716_abnormal_immune_system1.40910315
48MP0005025_abnormal_response_to1.40731315
49MP0001545_abnormal_hematopoietic_system1.40705681
50MP0005397_hematopoietic_system_phenotyp1.40705681
51MP0003075_altered_response_to1.39792875
52MP0004185_abnormal_adipocyte_glucose1.39788711
53MP0000703_abnormal_thymus_morphology1.37687727
54MP0001533_abnormal_skeleton_physiology1.36788894
55MP0002933_joint_inflammation1.35111487
56MP0005423_abnormal_somatic_nervous1.33925816
57MP0009840_abnormal_foam_cell1.33457444
58MP0003091_abnormal_cell_migration1.33087316
59MP0002722_abnormal_immune_system1.32960456
60MP0000681_abnormal_thyroid_gland1.31177647
61MP0009333_abnormal_splenocyte_physiolog1.30900655
62MP0002419_abnormal_innate_immunity1.28405852
63MP0000465_gastrointestinal_hemorrhage1.27764785
64MP0002998_abnormal_bone_remodeling1.27721379
65MP0000689_abnormal_spleen_morphology1.27396677
66* MP0001845_abnormal_inflammatory_respons1.25217910
67MP0004808_abnormal_hematopoietic_stem1.24665165
68MP0005670_abnormal_white_adipose1.24030270
69MP0005023_abnormal_wound_healing1.23794737
70MP0003448_altered_tumor_morphology1.23364527
71MP0003329_amyloid_beta_deposits1.18661080
72MP0000733_abnormal_muscle_development1.18023942
73* MP0002429_abnormal_blood_cell1.16604268
74MP0001348_abnormal_lacrimal_gland1.15441905
75MP0003879_abnormal_hair_cell1.13330651
76MP0002877_abnormal_melanocyte_morpholog1.13213522
77MP0005666_abnormal_adipose_tissue1.12871825
78MP0003828_pulmonary_edema1.12751200
79MP0001849_ear_inflammation1.12733483
80MP0002006_tumorigenesis1.12560380
81MP0001958_emphysema1.11100925
82MP0000678_abnormal_parathyroid_gland1.09802469
83MP0002148_abnormal_hypersensitivity_rea1.06815842
84MP0009785_altered_susceptibility_to1.06371803
85MP0008569_lethality_at_weaning1.05409161
86MP0000604_amyloidosis1.04332904
87MP0002060_abnormal_skin_morphology1.02375171
88MP0003279_aneurysm1.01682975
89MP0001853_heart_inflammation1.00197235
90MP0000858_altered_metastatic_potential0.99654167
91MP0005167_abnormal_blood-brain_barrier0.97865009
92MP0004381_abnormal_hair_follicle0.93827059
93MP0005535_abnormal_body_temperature0.92624589
94MP0003787_abnormal_imprinting0.91955582
95MP0001216_abnormal_epidermal_layer0.90771466
96MP0002064_seizures0.90630712
97MP0000343_altered_response_to0.89365485
98MP0003635_abnormal_synaptic_transmissio0.86401087
99MP0002928_abnormal_bile_duct0.86114240
100MP0009379_abnormal_foot_pigmentation0.85912563
101MP0002396_abnormal_hematopoietic_system0.84765245
102MP0005409_darkened_coat_color0.84591350
103MP0005375_adipose_tissue_phenotype0.84411170
104MP0002136_abnormal_kidney_physiology0.83470156
105MP0000767_abnormal_smooth_muscle0.83360460
106MP0009115_abnormal_fat_cell0.83124417
107MP0005390_skeleton_phenotype0.83094754
108MP0004130_abnormal_muscle_cell0.82652236
109MP0000490_abnormal_crypts_of0.82207682
110MP0005377_hearing/vestibular/ear_phenot0.81820013
111MP0003878_abnormal_ear_physiology0.81820013
112MP0003656_abnormal_erythrocyte_physiolo0.79804844
113MP0005623_abnormal_meninges_morphology0.78569845
114* MP0000249_abnormal_blood_vessel0.77997195
115MP0001663_abnormal_digestive_system0.77006712
116MP0008995_early_reproductive_senescence0.76893509
117MP0002063_abnormal_learning/memory/cond0.76753429
118MP0009931_abnormal_skin_appearance0.76146647
119MP0005381_digestive/alimentary_phenotyp0.74662299
120MP0000477_abnormal_intestine_morphology0.74375026
121MP0005058_abnormal_lysosome_morphology0.74147312
122MP0002132_abnormal_respiratory_system0.73444979
123* MP0005166_decreased_susceptibility_to0.72651567
124MP0002925_abnormal_cardiovascular_devel0.72468247
125MP0008438_abnormal_cutaneous_collagen0.72384900
126MP0005334_abnormal_fat_pad0.72339417
127MP0008469_abnormal_protein_level0.72256353
128MP0003795_abnormal_bone_structure0.71621101
129MP0000003_abnormal_adipose_tissue0.70919000
130MP0001765_abnormal_ion_homeostasis0.70059682
131MP0004742_abnormal_vestibular_system0.69418388
132MP0002796_impaired_skin_barrier0.69206271
133MP0003172_abnormal_lysosome_physiology0.68753111
134MP0003283_abnormal_digestive_organ0.67554324

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.38104937
2Interstitial pulmonary disease (HP:0006530)3.52331689
3Papilledema (HP:0001085)3.38778056
4Abnormality of the nasal mucosa (HP:0000433)3.32839475
5Nasal polyposis (HP:0100582)3.26424925
6Colitis (HP:0002583)3.12111102
7Pustule (HP:0200039)3.00993974
8Chronic otitis media (HP:0000389)3.00786347
9Cellulitis (HP:0100658)2.97511664
10Eczematoid dermatitis (HP:0000976)2.97031858
11Aortic aneurysm (HP:0004942)2.96944476
12Inflammation of the large intestine (HP:0002037)2.96266382
13Gastrointestinal inflammation (HP:0004386)2.94414637
14Increased density of long bones (HP:0006392)2.89596785
15Disproportionate tall stature (HP:0001519)2.86505407
16Mitral valve prolapse (HP:0001634)2.81276550
17Hematochezia (HP:0002573)2.80661918
18Spontaneous hematomas (HP:0007420)2.71350964
19Growth hormone excess (HP:0000845)2.69446860
20Verrucae (HP:0200043)2.63725805
21Papilloma (HP:0012740)2.63725805
22Broad face (HP:0000283)2.62747578
23Obstructive lung disease (HP:0006536)2.62742543
24Chronic obstructive pulmonary disease (HP:0006510)2.62742543
25Increased IgE level (HP:0003212)2.61276554
26Abnormality of the aortic arch (HP:0012303)2.61086885
27Shallow orbits (HP:0000586)2.59763081
28Mediastinal lymphadenopathy (HP:0100721)2.56998014
29Hyperacusis (HP:0010780)2.55551524
30Emphysema (HP:0002097)2.49725994
31Abnormality of binocular vision (HP:0011514)2.49261520
32Diplopia (HP:0000651)2.49261520
33Persistence of primary teeth (HP:0006335)2.48827425
34Annular pancreas (HP:0001734)2.46408936
35Recurrent fungal infections (HP:0002841)2.46295732
36Elevated erythrocyte sedimentation rate (HP:0003565)2.44890433
37Abnormality of the fingertips (HP:0001211)2.44318431
38Aortic dissection (HP:0002647)2.44195120
39Arterial tortuosity (HP:0005116)2.43713454
40Striae distensae (HP:0001065)2.43617900
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.39928352
42Recurrent bronchitis (HP:0002837)2.39756785
43Recurrent bacterial skin infections (HP:0005406)2.39453999
44Seborrheic dermatitis (HP:0001051)2.38950309
45Polygenic inheritance (HP:0010982)2.37404818
46Stomatitis (HP:0010280)2.37378971
47Milia (HP:0001056)2.36370941
48Spinal canal stenosis (HP:0003416)2.31242183
49Hyperthyroidism (HP:0000836)2.29911044
50IgM deficiency (HP:0002850)2.29321476
51Germ cell neoplasia (HP:0100728)2.25271935
52Abnormality of macrophages (HP:0004311)2.24326907
53Dilatation of the ascending aorta (HP:0005111)2.24255403
54Polycythemia (HP:0001901)2.23665900
55Segmental peripheral demyelination/remyelination (HP:0003481)2.22346132
56Aneurysm (HP:0002617)2.22317259
57Supranuclear gaze palsy (HP:0000605)2.21807278
58Stridor (HP:0010307)2.20938728
59Vascular tortuosity (HP:0004948)2.17866504
60Ulnar bowing (HP:0003031)2.15841793
61Hypercortisolism (HP:0001578)2.15622552
62Recurrent viral infections (HP:0004429)2.14497360
63Sleep apnea (HP:0010535)2.13201620
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12483618
65Pulmonary infiltrates (HP:0002113)2.11502745
66Restrictive lung disease (HP:0002091)2.08228964
67Atrophic scars (HP:0001075)2.06100533
68Arnold-Chiari malformation (HP:0002308)2.05247103
69Supernumerary ribs (HP:0005815)2.02635570
70Bronchomalacia (HP:0002780)2.01845988
71Stomach cancer (HP:0012126)2.00935566
72Rectal prolapse (HP:0002035)1.99392153
73Truncus arteriosus (HP:0001660)1.99080086
74Myocardial infarction (HP:0001658)1.98546198
75Panhypogammaglobulinemia (HP:0003139)1.97992820
76Slow saccadic eye movements (HP:0000514)1.96163357
77Thin bony cortex (HP:0002753)1.95681309
78Achilles tendon contracture (HP:0001771)1.93419107
79Myositis (HP:0100614)1.93403523
80Broad metatarsal (HP:0001783)1.93100729
81Recurrent skin infections (HP:0001581)1.92715724
82Ankle clonus (HP:0011448)1.92451706
83Agammaglobulinemia (HP:0004432)1.89669934
84Stereotypic behavior (HP:0000733)1.88940992
85Gastrointestinal stroma tumor (HP:0100723)1.88350255
86Fatigue (HP:0012378)1.87487666
87Abnormality of T cell physiology (HP:0011840)1.87179173
88Genu recurvatum (HP:0002816)1.85991746
89Abnormality of the gastric mucosa (HP:0004295)1.85959943
90Abnormality of polysaccharide metabolism (HP:0011012)1.85905250
91Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85905250
92Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85905250
93Systemic lupus erythematosus (HP:0002725)1.85323133
94T lymphocytopenia (HP:0005403)1.84492840
95Easy fatigability (HP:0003388)1.82672406
96Recurrent cutaneous fungal infections (HP:0011370)1.82060726
97Chronic mucocutaneous candidiasis (HP:0002728)1.82060726
98Abnormality of the columella (HP:0009929)1.81927039
99Hypochromic anemia (HP:0001931)1.81290397
100Abnormality of the radial head (HP:0003995)1.80832326
101Peripheral hypomyelination (HP:0007182)1.79563106
102Supernumerary bones of the axial skeleton (HP:0009144)1.79273236
103Insomnia (HP:0100785)1.79242189
104Hypertensive crisis (HP:0100735)1.77456911
105Abnormality of the prostate (HP:0008775)1.77456266
106Dislocated radial head (HP:0003083)1.75963611
107Mucopolysacchariduria (HP:0008155)1.75203959
108Urinary glycosaminoglycan excretion (HP:0003541)1.75203959
109Acne (HP:0001061)1.75114457
110Abnormality of incisor morphology (HP:0011063)1.74712594
111Abnormality of the Achilles tendon (HP:0005109)1.74582361
112Bicuspid aortic valve (HP:0001647)1.74231302
113Epistaxis (HP:0000421)1.74224909
114Abnormality of T cell number (HP:0011839)1.72874816
115Increased cerebral lipofuscin (HP:0011813)1.72740336
116Arterial thrombosis (HP:0004420)1.72065800
117Lymphopenia (HP:0001888)1.71623447
118J-shaped sella turcica (HP:0002680)1.71021765
119Abnormality of male internal genitalia (HP:0000022)1.69283971
120Dysostosis multiplex (HP:0000943)1.69144592
121Obstructive sleep apnea (HP:0002870)1.68919741
122Upper limb amyotrophy (HP:0009129)1.68456299
123Distal upper limb amyotrophy (HP:0007149)1.68456299
124Impaired platelet aggregation (HP:0003540)1.67350462
125Abnormal platelet function (HP:0011869)1.67350462
126Protrusio acetabuli (HP:0003179)1.66648674
127Onion bulb formation (HP:0003383)1.66391685
128Recurrent gram-negative bacterial infections (HP:0005420)1.65155714
129Chest pain (HP:0100749)1.65110203
130Abnormality of T cells (HP:0002843)1.64467705
131Increased connective tissue (HP:0009025)1.64426185
132Neonatal hypoglycemia (HP:0001998)1.64371533
133Mitral regurgitation (HP:0001653)1.63939527
134Lower limb asymmetry (HP:0100559)1.63892824
135Camptodactyly of toe (HP:0001836)1.63791046
136Meningitis (HP:0001287)1.63457432
137Macroorchidism (HP:0000053)1.63326358
138Acanthosis nigricans (HP:0000956)1.63182309
139Increased CSF protein (HP:0002922)1.62444166
140Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62349899
141Hemoptysis (HP:0002105)1.61602630
142Narrow palate (HP:0000189)1.61290699
143Prostate neoplasm (HP:0100787)1.60820793
144Bladder diverticulum (HP:0000015)1.60279021
145Vasculitis (HP:0002633)1.59927191
146Glomerulonephritis (HP:0000099)1.59498275
147Premature rupture of membranes (HP:0001788)1.59339123
148Mildly elevated creatine phosphokinase (HP:0008180)1.59124843
149Ankle contracture (HP:0006466)1.56948921
150Autoimmune thrombocytopenia (HP:0001973)1.56091383
151Recurrent abscess formation (HP:0002722)1.56078959
152Subacute progressive viral hepatitis (HP:0006572)1.54621876
153Gastrointestinal infarctions (HP:0005244)1.54514317
154Deep palmar crease (HP:0006191)1.53632587
155Chronic diarrhea (HP:0002028)1.52967731
156Reticulocytosis (HP:0001923)1.52022237
157Prolonged bleeding time (HP:0003010)1.51358437
158Abnormal platelet volume (HP:0011876)1.49907916
159Hand muscle atrophy (HP:0009130)1.49543552
160Fragile skin (HP:0001030)1.49164989
161Skin ulcer (HP:0200042)1.48902556
162Somatic mutation (HP:0001428)1.48886657
163Esophageal varix (HP:0002040)1.48754268

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.92378809
2MAP3K103.85036279
3PRPF4B3.56709958
4TRIB33.40876672
5EEF2K3.33436406
6MAPK153.04666581
7TGFBR22.82938988
8ERN12.75481342
9EPHB12.65414772
10PKN22.18174418
11STK102.06218482
12SMG11.94430374
13FGFR41.90541534
14RIPK41.86157331
15PTK61.77700164
16GRK61.75730687
17TBK11.67611307
18SIK31.61182652
19RIPK11.59808718
20TYK21.54690318
21MAP2K21.52526875
22SIK11.45155789
23CDK121.42168653
24ITK1.41356051
25ZAP701.40919150
26LRRK21.38904086
27MAP3K141.34419672
28JAK11.33941180
29JAK31.31071410
30EPHA31.29311467
31DMPK1.26560733
32UHMK11.24856342
33CAMKK11.24335557
34ICK1.23374529
35IRAK41.22438778
36PRKD31.21420490
37CHUK1.20858011
38TSSK61.19106431
39CSK1.17994976
40BMX1.15782384
41IKBKE1.15411603
42IKBKB1.14167299
43IRAK21.08540027
44TXK1.04868515
45TAOK11.03247595
46SIK21.01123874
47BLK1.00289635
48FGFR30.97712621
49HIPK20.97072175
50ALK0.96519610
51HCK0.96416707
52TAOK20.95779909
53CLK10.95610614
54JAK20.94517642
55CSF1R0.93426805
56IRAK10.90738137
57BTK0.90382532
58PAK40.88587680
59PIM10.87560435
60MAP3K130.87018205
61MAP3K30.84512929
62MAP3K70.83775827
63PRKCH0.82847359
64MAP2K30.82346629
65MAPK40.81547155
66PDGFRB0.80787858
67PDGFRA0.80409523
68TYRO30.79052832
69GSK3A0.78629079
70PRKD20.78094879
71MAP3K10.77260442
72LCK0.75811674
73PAK20.74022312
74MARK30.73745440
75MST40.73158382
76MAP3K110.72881798
77PTK20.71535590
78PDPK10.71526811
79NLK0.70740183
80NTRK20.70509423
81TTN0.70115440
82CDC42BPA0.69665804
83RPS6KA40.69199132
84RET0.67664863
85KIT0.67096860
86DYRK1B0.66864910
87MTOR0.66729406
88SGK30.65454676
89NTRK30.64820920
90IRAK30.64789770
91TAOK30.64762294
92STK110.61479816
93PRKD10.61454947
94RPS6KA10.59755412
95MAPKAPK20.59710381
96SGK20.59079993
97SGK2230.59063287
98SGK4940.59063287
99MARK20.58019536
100SYK0.57109833
101CAMK1G0.56706095
102RPS6KA60.55168908
103BRD40.55143573
104MAPK110.54346283
105CAMK1D0.54225147
106MAP3K20.53998393
107EPHA20.51261803
108CAMK40.49717656
109PRKCQ0.49176581
110RPS6KB20.48290824
111MAPK30.48172355
112RPS6KA20.48084988
113CDK60.46426206
114TNK20.44922117
115RPS6KL10.44194086
116RPS6KC10.44194086
117CAMK10.43786246
118PDK10.43489955
119* MAPK80.42947185
120MAP3K80.42379408
121LYN0.41608062
122RPS6KA50.41406030
123BMPR20.41249688
124MAPK70.41120739
125FGFR20.41117906
126MAPKAPK30.40425719
127INSR0.39459836
128CDK40.39450272
129FES0.38891137
130CDK90.38553343
131MAPK120.37319883

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.33973889
2* Osteoclast differentiation_Homo sapiens_hsa043802.30030769
3Chronic myeloid leukemia_Homo sapiens_hsa052201.96286608
4Primary immunodeficiency_Homo sapiens_hsa053401.93962981
5T cell receptor signaling pathway_Homo sapiens_hsa046601.93134771
6Toxoplasmosis_Homo sapiens_hsa051451.85497434
7Leishmaniasis_Homo sapiens_hsa051401.79608415
8Acute myeloid leukemia_Homo sapiens_hsa052211.69246192
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69037812
10Antigen processing and presentation_Homo sapiens_hsa046121.68494104
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.65063433
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.60934910
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58537921
14Autoimmune thyroid disease_Homo sapiens_hsa053201.55636113
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.48030879
16Measles_Homo sapiens_hsa051621.45240332
17Pancreatic cancer_Homo sapiens_hsa052121.45015258
18TNF signaling pathway_Homo sapiens_hsa046681.43863243
19Allograft rejection_Homo sapiens_hsa053301.42890914
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38386056
21VEGF signaling pathway_Homo sapiens_hsa043701.34563327
22Small cell lung cancer_Homo sapiens_hsa052221.34433337
23Cocaine addiction_Homo sapiens_hsa050301.34201464
24Prolactin signaling pathway_Homo sapiens_hsa049171.33754406
25Renal cell carcinoma_Homo sapiens_hsa052111.33299234
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32025970
27Graft-versus-host disease_Homo sapiens_hsa053321.31856704
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26122232
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.24943074
30Notch signaling pathway_Homo sapiens_hsa043301.24547667
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.24114178
32Apoptosis_Homo sapiens_hsa042101.22556235
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22414275
34Chemokine signaling pathway_Homo sapiens_hsa040621.21648781
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20708825
36Amphetamine addiction_Homo sapiens_hsa050311.18912421
37Hepatitis B_Homo sapiens_hsa051611.18238373
38Non-small cell lung cancer_Homo sapiens_hsa052231.16854383
39Long-term potentiation_Homo sapiens_hsa047201.14937966
40GnRH signaling pathway_Homo sapiens_hsa049121.14284272
41Focal adhesion_Homo sapiens_hsa045101.13171041
42Platelet activation_Homo sapiens_hsa046111.12340395
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11867815
44Dorso-ventral axis formation_Homo sapiens_hsa043201.11835694
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.11072563
46Colorectal cancer_Homo sapiens_hsa052101.10002380
47Type I diabetes mellitus_Homo sapiens_hsa049401.09927604
48Asthma_Homo sapiens_hsa053101.09694490
49Amoebiasis_Homo sapiens_hsa051461.08635881
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08350591
51Estrogen signaling pathway_Homo sapiens_hsa049151.08054231
52Insulin resistance_Homo sapiens_hsa049311.07902648
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04410000
54Prion diseases_Homo sapiens_hsa050201.02036025
55Influenza A_Homo sapiens_hsa051641.01442253
56Bladder cancer_Homo sapiens_hsa052190.99300893
57Endocytosis_Homo sapiens_hsa041440.99192411
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.98994245
59HTLV-I infection_Homo sapiens_hsa051660.98499824
60Pertussis_Homo sapiens_hsa051330.97790132
61Shigellosis_Homo sapiens_hsa051310.96923361
62Proteoglycans in cancer_Homo sapiens_hsa052050.94974262
63Hematopoietic cell lineage_Homo sapiens_hsa046400.93678064
64Salmonella infection_Homo sapiens_hsa051320.93207190
65Endometrial cancer_Homo sapiens_hsa052130.92555752
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92261388
67ECM-receptor interaction_Homo sapiens_hsa045120.92116925
68* MAPK signaling pathway_Homo sapiens_hsa040100.91129565
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90607450
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90303762
71Staphylococcus aureus infection_Homo sapiens_hsa051500.89484228
72Type II diabetes mellitus_Homo sapiens_hsa049300.88964015
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88798207
74Inositol phosphate metabolism_Homo sapiens_hsa005620.88783393
75Adherens junction_Homo sapiens_hsa045200.88495567
76Malaria_Homo sapiens_hsa051440.87844089
77Tuberculosis_Homo sapiens_hsa051520.86765056
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86490870
79Glioma_Homo sapiens_hsa052140.85905761
80mTOR signaling pathway_Homo sapiens_hsa041500.83619085
81Viral myocarditis_Homo sapiens_hsa054160.83530855
82Hepatitis C_Homo sapiens_hsa051600.82661570
83Prostate cancer_Homo sapiens_hsa052150.81085879
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80062309
85Legionellosis_Homo sapiens_hsa051340.79791786
86FoxO signaling pathway_Homo sapiens_hsa040680.79272500
87Cholinergic synapse_Homo sapiens_hsa047250.79010416
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78598023
89MicroRNAs in cancer_Homo sapiens_hsa052060.78190250
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77580514
91Renin secretion_Homo sapiens_hsa049240.76671442
92Viral carcinogenesis_Homo sapiens_hsa052030.76324171
93Circadian entrainment_Homo sapiens_hsa047130.73406595
94Rheumatoid arthritis_Homo sapiens_hsa053230.72420598
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71419782
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.70545401
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.70499813
98Pathways in cancer_Homo sapiens_hsa052000.69850795
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68826147
100Oxytocin signaling pathway_Homo sapiens_hsa049210.68402728
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68112668
102Circadian rhythm_Homo sapiens_hsa047100.67744695
103Herpes simplex infection_Homo sapiens_hsa051680.67492353
104cAMP signaling pathway_Homo sapiens_hsa040240.67138724
105ErbB signaling pathway_Homo sapiens_hsa040120.66323452
106Insulin secretion_Homo sapiens_hsa049110.66272642
107Rap1 signaling pathway_Homo sapiens_hsa040150.65192577
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.64234105
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63771776
110Lysosome_Homo sapiens_hsa041420.63169470
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63160371
112Choline metabolism in cancer_Homo sapiens_hsa052310.62194548
113Gastric acid secretion_Homo sapiens_hsa049710.62030640
114Protein digestion and absorption_Homo sapiens_hsa049740.60851598
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59457695
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58914138
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.58034415
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55930280
119Other glycan degradation_Homo sapiens_hsa005110.53852405
120HIF-1 signaling pathway_Homo sapiens_hsa040660.53745788
121Insulin signaling pathway_Homo sapiens_hsa049100.51597279
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51096661
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49691375
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49488625
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48814296

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