KANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.65868646
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.65868646
3L-phenylalanine metabolic process (GO:0006558)4.36760862
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36760862
5positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.26954827
6glyoxylate metabolic process (GO:0046487)4.25687104
7alpha-linolenic acid metabolic process (GO:0036109)4.13213182
8low-density lipoprotein particle remodeling (GO:0034374)3.95162812
9aromatic amino acid family catabolic process (GO:0009074)3.78912939
10regulation of cholesterol esterification (GO:0010872)3.78615499
11regulation of apoptotic cell clearance (GO:2000425)3.78321675
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75587120
13bile acid biosynthetic process (GO:0006699)3.58029538
14lysine catabolic process (GO:0006554)3.56236900
15lysine metabolic process (GO:0006553)3.56236900
16sulfur amino acid catabolic process (GO:0000098)3.53523708
17regulation of cholesterol storage (GO:0010885)3.52932384
18negative regulation of fibrinolysis (GO:0051918)3.51555092
19cysteine metabolic process (GO:0006534)3.50061836
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.49215749
21peptidyl-glutamic acid carboxylation (GO:0017187)3.46067277
22protein carboxylation (GO:0018214)3.46067277
23acetyl-CoA metabolic process (GO:0006084)3.45219918
24positive regulation of fatty acid beta-oxidation (GO:0032000)3.38208770
25fatty acid beta-oxidation (GO:0006635)3.35426246
26positive regulation of lipid storage (GO:0010884)3.34406378
27homocysteine metabolic process (GO:0050667)3.31623257
28kynurenine metabolic process (GO:0070189)3.31302662
29regulation of protein activation cascade (GO:2000257)3.31134372
30intestinal cholesterol absorption (GO:0030299)3.30275705
31complement activation, alternative pathway (GO:0006957)3.30255764
32regulation of fibrinolysis (GO:0051917)3.29958490
33plasma lipoprotein particle assembly (GO:0034377)3.29156820
34myelination in peripheral nervous system (GO:0022011)3.27730563
35peripheral nervous system axon ensheathment (GO:0032292)3.27730563
36very-low-density lipoprotein particle assembly (GO:0034379)3.25673806
37protein-lipid complex assembly (GO:0065005)3.25052535
38amino-acid betaine metabolic process (GO:0006577)3.22545270
39desmosome organization (GO:0002934)3.20103257
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.19678678
41plasma lipoprotein particle clearance (GO:0034381)3.19330754
42fatty acid oxidation (GO:0019395)3.16248766
43cholesterol efflux (GO:0033344)3.15398728
44positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.15252090
45regulation of complement activation (GO:0030449)3.14745533
46high-density lipoprotein particle remodeling (GO:0034375)3.13616052
47regulation of heterotypic cell-cell adhesion (GO:0034114)3.12696079
48lipid oxidation (GO:0034440)3.11002841
49indolalkylamine catabolic process (GO:0046218)3.10973716
50tryptophan catabolic process (GO:0006569)3.10973716
51indole-containing compound catabolic process (GO:0042436)3.10973716
52fatty acid elongation (GO:0030497)3.10634400
53plasma lipoprotein particle organization (GO:0071827)3.09093826
54protein-lipid complex subunit organization (GO:0071825)3.08071064
55bile acid metabolic process (GO:0008206)3.07699643
56fusion of sperm to egg plasma membrane (GO:0007342)3.07498834
57serine family amino acid catabolic process (GO:0009071)3.07448879
58regulation of cardioblast differentiation (GO:0051890)3.07193314
59regulation of triglyceride catabolic process (GO:0010896)3.04608849
60very long-chain fatty acid metabolic process (GO:0000038)3.04082773
61negative regulation of hemostasis (GO:1900047)3.03081962
62negative regulation of blood coagulation (GO:0030195)3.03081962
63regulation of membrane protein ectodomain proteolysis (GO:0051043)3.02136291
64blood coagulation, intrinsic pathway (GO:0007597)3.01089919
65fatty acid catabolic process (GO:0009062)3.00967676
66linoleic acid metabolic process (GO:0043651)3.00765368
67triglyceride homeostasis (GO:0070328)2.99907017
68acylglycerol homeostasis (GO:0055090)2.99907017
69short-chain fatty acid metabolic process (GO:0046459)2.98027875
70fatty acid transmembrane transport (GO:1902001)2.97898811
71acute-phase response (GO:0006953)2.97811898
72fibrinolysis (GO:0042730)2.97747833
73cellular glucuronidation (GO:0052695)2.96740004
74tryptophan metabolic process (GO:0006568)2.96541798
75ovulation from ovarian follicle (GO:0001542)2.96056265
76regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.95309966
77positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.95197568
78negative regulation of lipase activity (GO:0060192)2.94874814
79acrosome reaction (GO:0007340)2.93623447
80positive regulation of fatty acid oxidation (GO:0046321)2.93145481
81reverse cholesterol transport (GO:0043691)2.92008966
82negative regulation of cholesterol transport (GO:0032375)2.90974120
83negative regulation of sterol transport (GO:0032372)2.90974120
84monocarboxylic acid catabolic process (GO:0072329)2.90155065
85diacylglycerol metabolic process (GO:0046339)2.89869810
86cellular ketone body metabolic process (GO:0046950)2.89722081
87regulation of cholesterol homeostasis (GO:2000188)2.89675868
88urea cycle (GO:0000050)2.87149569
89urea metabolic process (GO:0019627)2.87149569
902-oxoglutarate metabolic process (GO:0006103)2.85097798
91carnitine shuttle (GO:0006853)2.84278022
92negative regulation of coagulation (GO:0050819)2.83901244
93fatty-acyl-CoA biosynthetic process (GO:0046949)2.83618976
94regulation of plasminogen activation (GO:0010755)2.82911387
95tyrosine metabolic process (GO:0006570)2.79856384
96ethanol oxidation (GO:0006069)2.78832917
97alpha-amino acid catabolic process (GO:1901606)2.78439530
98positive regulation of steroid metabolic process (GO:0045940)2.77625518
99regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.76018040
100cellular modified amino acid catabolic process (GO:0042219)2.75438482
101negative regulation of protein activation cascade (GO:2000258)2.74165656
102thioester biosynthetic process (GO:0035384)2.73971826
103acyl-CoA biosynthetic process (GO:0071616)2.73971826
104acylglycerol catabolic process (GO:0046464)2.72036151
105neutral lipid catabolic process (GO:0046461)2.72036151
106aspartate family amino acid catabolic process (GO:0009068)2.71854613
107dicarboxylic acid biosynthetic process (GO:0043650)2.71813372
108carnitine metabolic process (GO:0009437)2.71464383
109phospholipid efflux (GO:0033700)2.70911809
110positive regulation of heat generation (GO:0031652)2.70874959
111sexual reproduction (GO:0019953)2.69208300
112positive regulation of blood coagulation (GO:0030194)2.69188949
113positive regulation of hemostasis (GO:1900048)2.69188949
114regulation of phospholipase A2 activity (GO:0032429)2.68895766
115lipoprotein metabolic process (GO:0042157)2.68397573
116plasma lipoprotein particle remodeling (GO:0034369)2.66641117
117protein-lipid complex remodeling (GO:0034368)2.66641117
118macromolecular complex remodeling (GO:0034367)2.66641117
119negative regulation of wound healing (GO:0061045)2.66595524
120nitrogen cycle metabolic process (GO:0071941)2.64316684
121cellular amino acid catabolic process (GO:0009063)2.64182382
122acyl-CoA metabolic process (GO:0006637)2.63343983
123thioester metabolic process (GO:0035383)2.63343983
124phospholipid homeostasis (GO:0055091)2.62727904
125positive regulation of lipid catabolic process (GO:0050996)2.62584466
126regulation of macrophage derived foam cell differentiation (GO:0010743)2.62375438
127aromatic amino acid family metabolic process (GO:0009072)2.62046093
128adhesion of symbiont to host cell (GO:0044650)2.61936115
129virion attachment to host cell (GO:0019062)2.61936115
130endocardial cushion development (GO:0003197)2.61173308
131cholesterol homeostasis (GO:0042632)2.60531818
132coenzyme catabolic process (GO:0009109)2.60407883
133regulation of fatty acid beta-oxidation (GO:0031998)2.59755510
134negative regulation of platelet activation (GO:0010544)2.58553745
135uronic acid metabolic process (GO:0006063)2.58412704
136glucuronate metabolic process (GO:0019585)2.58412704
137fatty-acyl-CoA metabolic process (GO:0035337)2.58270961
138positive regulation of fatty acid biosynthetic process (GO:0045723)2.57889885
139regulation of lipoprotein metabolic process (GO:0050746)2.57761613
140glutamate metabolic process (GO:0006536)2.57657028
141long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.57598108
142organic acid catabolic process (GO:0016054)2.57062447
143carboxylic acid catabolic process (GO:0046395)2.57062447
144sterol homeostasis (GO:0055092)2.56729597
145low-density lipoprotein particle clearance (GO:0034383)2.56606293
146regulation of cholesterol metabolic process (GO:0090181)2.54951765
147positive regulation of coagulation (GO:0050820)2.53633315
148regulation of fever generation (GO:0031620)2.49659434
149positive regulation of triglyceride lipase activity (GO:0061365)2.49208015
150positive regulation of lipoprotein lipase activity (GO:0051006)2.49208015
151response to muscle activity (GO:0014850)2.47252741
152negative regulation of lipid transport (GO:0032369)2.46665672
153opsonization (GO:0008228)2.45705927
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.45455911
155protein activation cascade (GO:0072376)2.42953512
156positive regulation of extracellular matrix organization (GO:1903055)2.42940272
157regulation of lipid storage (GO:0010883)2.41540352
158sperm motility (GO:0030317)2.39699668
159triglyceride catabolic process (GO:0019433)2.38675403
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.38213417
161regulation of vitamin D biosynthetic process (GO:0060556)2.38200492
162positive regulation of fatty acid metabolic process (GO:0045923)2.35483085
163cell proliferation involved in metanephros development (GO:0072203)2.35150617
164negative regulation of fatty acid transport (GO:2000192)2.35040071
165negative regulation of complement activation (GO:0045916)2.32773966
166plasma membrane fusion (GO:0045026)2.32082134
167intestinal absorption (GO:0050892)2.30415145
168apoptotic cell clearance (GO:0043277)2.28633315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.04953452
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.27839860
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.21191674
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01032959
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70887158
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.70001911
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.12270074
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.92347983
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69241095
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.65951341
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31849886
12CLOCK_20551151_ChIP-Seq_293T_Human2.30917731
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10221134
14* ESR2_21235772_ChIP-Seq_MCF-7_Human2.03770532
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.99788112
16ESR1_21235772_ChIP-Seq_MCF-7_Human1.93171437
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88197929
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81136610
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70031711
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67479827
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.65272271
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60718137
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58178363
24* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.54837459
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.52944124
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.52300642
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47507463
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44448860
29NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41221607
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38579407
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.33124002
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.33124002
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32009764
34CJUN_26792858_Chip-Seq_BT549_Human1.30738230
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28027017
36TP53_18474530_ChIP-ChIP_U2OS_Human1.27131400
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25124639
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25124639
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24603081
40GBX2_23144817_ChIP-Seq_PC3_Human1.22714989
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21085794
42AR_21572438_ChIP-Seq_LNCaP_Human1.20146059
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18676734
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18204228
45SOX2_20726797_ChIP-Seq_SW620_Human1.16666776
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13395459
47* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12836501
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12275839
49* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11246880
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10887807
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09858571
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.08682910
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08291888
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08121580
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.07827181
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.07164909
57* PIAS1_25552417_ChIP-Seq_VCAP_Human1.06108388
58AHR_22903824_ChIP-Seq_MCF-7_Human1.04235442
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03579353
60RXR_22108803_ChIP-Seq_LS180_Human1.02454073
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.01541762
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01027039
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00213095
64CDX2_20551321_ChIP-Seq_CACO-2_Human0.99180736
65GATA4_25053715_ChIP-Seq_YYC3_Human0.99137354
66EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99103133
67RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99103133
68GATA2_21666600_ChIP-Seq_HMVEC_Human0.99035708
69TP53_16413492_ChIP-PET_HCT116_Human0.98127032
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97078404
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96815891
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95956421
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94380041
74SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93952142
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93735968
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93336822
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92911616
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92911616
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92069262
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91775182
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91637256
82VDR_24787735_ChIP-Seq_THP-1_Human0.91163538
83SMAD3_21741376_ChIP-Seq_EPCs_Human0.90605675
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90605520
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90228457
86* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90024154
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89094835
88BCAT_22108803_ChIP-Seq_LS180_Human0.88767325
89* TP63_23658742_ChIP-Seq_EP156T_Human0.88766556
90* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88265915
91ERG_21242973_ChIP-ChIP_JURKAT_Human0.88260543
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87324609
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87217318
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86018936
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.85864422
96* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84764612
97* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84753500
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84695965
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84630065
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.83157183
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82681265
102TCF4_18268006_ChIP-ChIP_LS174T_Human0.82516090
103PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81477339
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.79927214
105EZH2_27294783_Chip-Seq_ESCs_Mouse0.79526454
106* TP53_23651856_ChIP-Seq_MEFs_Mouse0.79464049
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.79213947
108* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79137655
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79087341
110* STAT3_23295773_ChIP-Seq_U87_Human0.78806691
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78498492
112ZNF263_19887448_ChIP-Seq_K562_Human0.78309768
113JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77971648
114SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77901506
115* SMAD4_21799915_ChIP-Seq_A2780_Human0.77479671
116KDM2B_26808549_Chip-Seq_REH_Human0.77145372
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.77002914
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76760863
119GATA3_24758297_ChIP-Seq_MCF-7_Human0.76599403
120* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75937543
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75888994
122HTT_18923047_ChIP-ChIP_STHdh_Human0.75864512
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75372370
124DROSHA_22980978_ChIP-Seq_HELA_Human0.74993662
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.74799725
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74691972
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73654418
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.73507907
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.73507907
130SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.73497978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.47612997
2MP0005360_urolithiasis4.35090412
3MP0005085_abnormal_gallbladder_physiolo3.49745123
4MP0005365_abnormal_bile_salt3.30041093
5MP0005410_abnormal_fertilization3.27621389
6MP0003705_abnormal_hypodermis_morpholog2.76240246
7MP0005275_abnormal_skin_tensile2.75368220
8MP0005167_abnormal_blood-brain_barrier2.73957017
9MP0003646_muscle_fatigue2.63089831
10MP0008875_abnormal_xenobiotic_pharmacok2.49775862
11MP0003303_peritoneal_inflammation2.47339417
12MP0003252_abnormal_bile_duct2.46917729
13MP0002796_impaired_skin_barrier2.39647052
14MP0008438_abnormal_cutaneous_collagen2.33349110
15MP0003806_abnormal_nucleotide_metabolis2.28151797
16MP0003195_calcinosis2.18110985
17MP0004510_myositis2.15386043
18MP0004272_abnormal_basement_membrane2.12303465
19MP0010329_abnormal_lipoprotein_level2.10391934
20MP0002837_dystrophic_cardiac_calcinosis2.05164686
21MP0005332_abnormal_amino_acid1.86622134
22MP0009384_cardiac_valve_regurgitation1.83061122
23MP0004084_abnormal_cardiac_muscle1.79352943
24MP0003011_delayed_dark_adaptation1.78149849
25MP0004185_abnormal_adipocyte_glucose1.69553827
26MP0005451_abnormal_body_composition1.66919497
27MP0002138_abnormal_hepatobiliary_system1.65224503
28MP0002254_reproductive_system_inflammat1.62330953
29MP0001666_abnormal_nutrient_absorption1.61813006
30MP0004130_abnormal_muscle_cell1.59707884
31MP0005023_abnormal_wound_healing1.59077910
32MP0005670_abnormal_white_adipose1.58738282
33MP0000579_abnormal_nail_morphology1.57738720
34MP0003690_abnormal_glial_cell1.56476473
35MP0005666_abnormal_adipose_tissue1.55971595
36MP0003950_abnormal_plasma_membrane1.51577572
37MP0010368_abnormal_lymphatic_system1.50696170
38MP0009840_abnormal_foam_cell1.49464390
39MP0004036_abnormal_muscle_relaxation1.48353006
40MP0003191_abnormal_cellular_cholesterol1.46478031
41MP0002089_abnormal_postnatal_growth/wei1.45384111
42MP0002118_abnormal_lipid_homeostasis1.44882536
43MP0001661_extended_life_span1.44054576
44MP0003941_abnormal_skin_development1.43265797
45MP0005330_cardiomyopathy1.41811311
46MP0002060_abnormal_skin_morphology1.41715498
47MP0000751_myopathy1.39339774
48MP0005058_abnormal_lysosome_morphology1.37118645
49MP0004019_abnormal_vitamin_homeostasis1.34826496
50MP0000604_amyloidosis1.33935446
51MP0009115_abnormal_fat_cell1.32650782
52MP0005409_darkened_coat_color1.27053733
53MP0006054_spinal_hemorrhage1.25794297
54MP0005503_abnormal_tendon_morphology1.25564911
55MP0005257_abnormal_intraocular_pressure1.25020268
56MP0010234_abnormal_vibrissa_follicle1.23646366
57MP0009053_abnormal_anal_canal1.22895006
58MP0000467_abnormal_esophagus_morphology1.22098931
59MP0000647_abnormal_sebaceous_gland1.22083707
60MP0005164_abnormal_response_to1.22038475
61MP0003566_abnormal_cell_adhesion1.21343199
62MP0005501_abnormal_skin_physiology1.20791980
63MP0002108_abnormal_muscle_morphology1.19339056
64MP0010678_abnormal_skin_adnexa1.18349988
65MP0005408_hypopigmentation1.17969492
66MP0003075_altered_response_to1.17420907
67MP0005595_abnormal_vascular_smooth1.16883501
68MP0005623_abnormal_meninges_morphology1.16566521
69MP0006138_congestive_heart_failure1.15701994
70MP0001915_intracranial_hemorrhage1.14375239
71MP0000762_abnormal_tongue_morphology1.13934112
72MP0000383_abnormal_hair_follicle1.12915392
73MP0005375_adipose_tissue_phenotype1.12319431
74MP0000749_muscle_degeneration1.11654325
75MP0003172_abnormal_lysosome_physiology1.10503959
76MP0005083_abnormal_biliary_tract1.10265696
77MP0000566_synostosis1.08926906
78MP0008004_abnormal_stomach_pH1.08734491
79MP0008775_abnormal_heart_ventricle1.07564842
80MP0002332_abnormal_exercise_endurance1.06935170
81MP0002098_abnormal_vibrissa_morphology1.06865284
82MP0004087_abnormal_muscle_fiber1.04139112
83MP0003879_abnormal_hair_cell0.99853336
84MP0005620_abnormal_muscle_contractility0.99201591
85MP0004215_abnormal_myocardial_fiber0.98639724
86MP0002972_abnormal_cardiac_muscle0.98016644
87MP0009643_abnormal_urine_homeostasis0.97886556
88MP0000609_abnormal_liver_physiology0.97443934
89MP0000767_abnormal_smooth_muscle0.97196177
90MP0004484_altered_response_of0.96093732
91MP0002295_abnormal_pulmonary_circulatio0.96063740
92MP0000462_abnormal_digestive_system0.94738503
93MP0004134_abnormal_chest_morphology0.94196326
94MP0000343_altered_response_to0.93448964
95MP0005319_abnormal_enzyme/_coenzyme0.93382189
96MP0010030_abnormal_orbit_morphology0.92720428
97MP0003453_abnormal_keratinocyte_physiol0.92117898
98MP0001501_abnormal_sleep_pattern0.91661536
99MP0003868_abnormal_feces_composition0.91029431
100MP0005334_abnormal_fat_pad0.90736831
101MP0010630_abnormal_cardiac_muscle0.89898351
102MP0003329_amyloid_beta_deposits0.89751436
103MP0003279_aneurysm0.89670559
104MP0002282_abnormal_trachea_morphology0.88901653
105MP0003091_abnormal_cell_migration0.88386050
106MP0000427_abnormal_hair_cycle0.87949106
107MP0000920_abnormal_myelination0.86288886
108MP0002269_muscular_atrophy0.86225441
109MP0000013_abnormal_adipose_tissue0.85958920
110MP0000537_abnormal_urethra_morphology0.85939078
111MP0000249_abnormal_blood_vessel0.85615927
112MP0005647_abnormal_sex_gland0.84468743
113MP0003633_abnormal_nervous_system0.84169498
114MP0001544_abnormal_cardiovascular_syste0.84167823
115MP0005385_cardiovascular_system_phenoty0.84167823
116MP0002168_other_aberrant_phenotype0.84050540
117MP0005448_abnormal_energy_balance0.83849314
118MP0002933_joint_inflammation0.83724214
119MP0002998_abnormal_bone_remodeling0.83557897
120MP0009250_abnormal_appendicular_skeleto0.83180143
121MP0000747_muscle_weakness0.82968411
122MP0003878_abnormal_ear_physiology0.82708706
123MP0005377_hearing/vestibular/ear_phenot0.82708706
124MP0001879_abnormal_lymphatic_vessel0.81278991
125MP0003122_maternal_imprinting0.81173281
126MP0005379_endocrine/exocrine_gland_phen0.80863969
127MP0002971_abnormal_brown_adipose0.80740653
128MP0002896_abnormal_bone_mineralization0.80173124
129MP0000003_abnormal_adipose_tissue0.79561649
130MP0001216_abnormal_epidermal_layer0.77746652
131MP0005165_increased_susceptibility_to0.77656047
132MP0009780_abnormal_chondrocyte_physiolo0.77564195
133MP0002106_abnormal_muscle_physiology0.77462886
134MP0005166_decreased_susceptibility_to0.75557475
135MP0005535_abnormal_body_temperature0.74915104
136MP0001299_abnormal_eye_distance/0.74730562
137MP0003385_abnormal_body_wall0.74566925
138MP0002249_abnormal_larynx_morphology0.73978720
139MP0005584_abnormal_enzyme/coenzyme_acti0.73127243
140MP0000371_diluted_coat_color0.72742715
141MP0000377_abnormal_hair_follicle0.72355021
142MP0010771_integument_phenotype0.72324755
143MP0004381_abnormal_hair_follicle0.72302584
144MP0000163_abnormal_cartilage_morphology0.71401309
145MP0009764_decreased_sensitivity_to0.70829033
146MP0004145_abnormal_muscle_electrophysio0.70418329

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)4.82752666
2Deep venous thrombosis (HP:0002625)4.59807821
3Glomerulonephritis (HP:0000099)4.30613691
4Systemic lupus erythematosus (HP:0002725)4.15282780
5Xanthomatosis (HP:0000991)4.15103467
6Right ventricular cardiomyopathy (HP:0011663)4.12058245
7Hyperlipoproteinemia (HP:0010980)3.59952585
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.57091296
9Potter facies (HP:0002009)3.53062112
10Facial shape deformation (HP:0011334)3.53062112
11Asymmetric septal hypertrophy (HP:0001670)3.50420211
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.45692642
13Epidermoid cyst (HP:0200040)3.27404988
14Hyperglycinuria (HP:0003108)3.23911678
15Hyporeflexia of lower limbs (HP:0002600)3.20667862
16Hypoalphalipoproteinemia (HP:0003233)3.17106927
17Abnormality of serine family amino acid metabolism (HP:0010894)3.10826593
18Abnormality of glycine metabolism (HP:0010895)3.10826593
19Complement deficiency (HP:0004431)3.04079401
20Hypoglycemic coma (HP:0001325)3.04024276
21Ketosis (HP:0001946)2.89019090
22Prolonged partial thromboplastin time (HP:0003645)2.88242844
23Hyperglycinemia (HP:0002154)2.80591396
24Hypolipoproteinemia (HP:0010981)2.79182375
25Hyperammonemia (HP:0001987)2.76595940
26Muscle fiber splitting (HP:0003555)2.75129047
27Nephritis (HP:0000123)2.71426148
28Hypobetalipoproteinemia (HP:0003563)2.69796797
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.69304868
30Bundle branch block (HP:0011710)2.67400890
31Abnormality of fatty-acid metabolism (HP:0004359)2.67386780
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67379316
33Sudden death (HP:0001699)2.64830467
34Ketoacidosis (HP:0001993)2.62467112
35Small epiphyses (HP:0010585)2.56533728
36Spontaneous abortion (HP:0005268)2.55799093
37Broad metatarsal (HP:0001783)2.55329871
38Pigmentary retinal degeneration (HP:0001146)2.52241261
39Ventricular tachycardia (HP:0004756)2.51482734
40Increased connective tissue (HP:0009025)2.47357512
41Lymphangioma (HP:0100764)2.46929802
42Abnormality of the nasal septum (HP:0000419)2.45962123
43Vascular calcification (HP:0004934)2.35724560
44Abnormal cartilage morphology (HP:0002763)2.34508158
45Widely patent fontanelles and sutures (HP:0004492)2.34241062
46Cardiovascular calcification (HP:0011915)2.34076050
47Abnormality of carpal bone ossification (HP:0006257)2.34047236
48Hypoplastic ischia (HP:0003175)2.33181474
49Abnormality of the common coagulation pathway (HP:0010990)2.32509506
50Premature rupture of membranes (HP:0001788)2.31677186
51Abnormality of the ischium (HP:0003174)2.31418461
52Myoglobinuria (HP:0002913)2.30661200
53Neurofibrillary tangles (HP:0002185)2.26941518
54Fat malabsorption (HP:0002630)2.26899141
55Turricephaly (HP:0000262)2.25561654
56Flared iliac wings (HP:0002869)2.25224374
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23625799
58Epiphyseal dysplasia (HP:0002656)2.23592471
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.23231486
60Skin nodule (HP:0200036)2.22385456
61Abnormality of the intrinsic pathway (HP:0010989)2.20790123
62Exercise-induced myalgia (HP:0003738)2.20306758
63Hypophosphatemic rickets (HP:0004912)2.17167553
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.15864712
65Nuclear cataract (HP:0100018)2.13347939
66Hemorrhage of the eye (HP:0011885)2.12934149
67Atrial fibrillation (HP:0005110)2.11709530
68Vitreoretinal degeneration (HP:0000655)2.10629237
69Delayed CNS myelination (HP:0002188)2.06387524
70Hydroxyprolinuria (HP:0003080)2.05521602
71Abnormality of proline metabolism (HP:0010907)2.05521602
72Hamartoma of the eye (HP:0010568)2.04885427
73Abnormality of complement system (HP:0005339)2.04229171
74Coronal craniosynostosis (HP:0004440)2.03952071
75Abnormality of methionine metabolism (HP:0010901)2.03654201
76Protuberant abdomen (HP:0001538)2.02712862
77Hypotrichosis (HP:0001006)2.01583232
78Portal hypertension (HP:0001409)1.99736864
79Focal segmental glomerulosclerosis (HP:0000097)1.95204582
80Abnormal hand bone ossification (HP:0010660)1.92249071
81Metaphyseal cupping (HP:0003021)1.91537687
82Dicarboxylic aciduria (HP:0003215)1.91413203
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91413203
84Retinal atrophy (HP:0001105)1.90234846
85Osteomalacia (HP:0002749)1.89201526
86Syncope (HP:0001279)1.89125880
87Abnormality of liposaccharide metabolism (HP:0010968)1.88814241
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.88814241
89Abnormality of glycolipid metabolism (HP:0010969)1.88814241
90Acanthosis nigricans (HP:0000956)1.87296625
91Abnormal ossification of hand bones (HP:0005921)1.87047447
92Hypercholesterolemia (HP:0003124)1.86416973
93Type 1 muscle fiber predominance (HP:0003803)1.86065313
94Mitral stenosis (HP:0001718)1.85928678
95Hypoglycemic seizures (HP:0002173)1.85862207
96Aortic aneurysm (HP:0004942)1.85457918
97Exercise-induced muscle cramps (HP:0003710)1.84290920
98Abnormal tarsal ossification (HP:0008369)1.83516196
99Amyloidosis (HP:0011034)1.83384398
100Primary atrial arrhythmia (HP:0001692)1.82845202
101Cerebral aneurysm (HP:0004944)1.82677504
102Generalized aminoaciduria (HP:0002909)1.80809350
103Ovoid vertebral bodies (HP:0003300)1.80500670
104Abnormal atrioventricular conduction (HP:0005150)1.79698827
105Abnormality of the hepatic vasculature (HP:0006707)1.79191850
106Arthropathy (HP:0003040)1.78883258
107Heart block (HP:0012722)1.78358314
108Mucopolysacchariduria (HP:0008155)1.78229313
109Urinary glycosaminoglycan excretion (HP:0003541)1.78229313
110Abnormality of the parathyroid morphology (HP:0011766)1.77949624
111Scapular winging (HP:0003691)1.77897758
112Joint hemorrhage (HP:0005261)1.76522043
113Abnormal urine output (HP:0012590)1.76260413
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75955007
115Cerebral inclusion bodies (HP:0100314)1.75487281
116Visceral angiomatosis (HP:0100761)1.75142905
117Glomerulosclerosis (HP:0000096)1.74975631
118Purpura (HP:0000979)1.74706498
119Protrusio acetabuli (HP:0003179)1.74470740
120Abnormality of purine metabolism (HP:0004352)1.74376284
121Neonatal short-limb short stature (HP:0008921)1.74310268
122Abnormality of the calf musculature (HP:0001430)1.74289861
123Back pain (HP:0003418)1.73607795
124Advanced eruption of teeth (HP:0006288)1.73521597
125Menorrhagia (HP:0000132)1.73029232
126Difficulty running (HP:0009046)1.72641801
127Conjugated hyperbilirubinemia (HP:0002908)1.71972283
128Lipoatrophy (HP:0100578)1.71346598
129Abnormality of polysaccharide metabolism (HP:0011012)1.71024146
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71024146
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71024146
132Muscle hypertrophy of the lower extremities (HP:0008968)1.70814274
133Bradycardia (HP:0001662)1.69899253
134Abnormality of the wing of the ilium (HP:0011867)1.69817038
135Malnutrition (HP:0004395)1.69164295
136Mesangial abnormality (HP:0001966)1.68903548
137Rickets (HP:0002748)1.67902612
138Delayed epiphyseal ossification (HP:0002663)1.67201146
139Thick nail (HP:0001805)1.67107954
140Cupped ribs (HP:0000887)1.67092761
141Myocardial infarction (HP:0001658)1.66646940
142Severe visual impairment (HP:0001141)1.65528565
143Dysostosis multiplex (HP:0000943)1.65407946
144Hyperinsulinemic hypoglycemia (HP:0000825)1.64284094
145Supraventricular tachycardia (HP:0004755)1.62717793
146Calf muscle hypertrophy (HP:0008981)1.62252526
147Dilated cardiomyopathy (HP:0001644)1.61858685
148Esophageal varix (HP:0002040)1.61855168
149Wide anterior fontanel (HP:0000260)1.61112116
150Abnormal gallbladder morphology (HP:0012437)1.61050423
151Limited hip movement (HP:0008800)1.60344631
152Increased variability in muscle fiber diameter (HP:0003557)1.60205497
153Relative macrocephaly (HP:0004482)1.60143943
154Atrophic scars (HP:0001075)1.59493566
155Periauricular skin pits (HP:0100277)1.59341732
156Preauricular pit (HP:0004467)1.59341732
157Natal tooth (HP:0000695)1.59181794
158Neonatal death (HP:0003811)1.59147716
159Supraventricular arrhythmia (HP:0005115)1.58681137
160Metaphyseal irregularity (HP:0003025)1.58500802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.15930988
2PRPF4B3.77102966
3IRAK32.75838528
4SIK12.71521201
5AKT32.56117656
6STK392.42283156
7BCKDK2.39488609
8EPHB22.33091564
9TTN2.26725387
10EPHB12.12418751
11TYRO32.05091755
12WNK42.03718765
13TRIB32.01927329
14MET2.01399818
15NUAK11.99127601
16FGFR21.96979100
17ICK1.94766112
18STK38L1.90616296
19OBSCN1.87664575
20DDR21.79183903
21MYLK1.76549870
22FGFR41.65073547
23PDGFRA1.60515293
24TAOK21.60008980
25ERN11.53115973
26GRK71.51750234
27MST1R1.49636757
28MAP3K31.49404175
29PAK31.47430750
30TESK11.45185459
31PTK61.43832517
32MKNK21.40805526
33TNIK1.38489565
34INSRR1.37008772
35TIE11.36264618
36PKN21.33152224
37DMPK1.31258239
38ROCK11.28225399
39OXSR11.27639706
40ACVR1B1.22674387
41FER1.20845549
42MAP3K111.20758939
43PHKG11.20621713
44PHKG21.20621713
45PIK3CA1.15237225
46PTK21.14806516
47RIPK11.07812669
48PKN11.07080397
49PIK3CG1.07051871
50LMTK21.04670853
51STK31.03452855
52ERBB41.03312981
53TAOK11.02692738
54BCR1.02461158
55PLK41.02367136
56FRK0.99473108
57STK380.98845559
58PDGFRB0.92927892
59WNK10.92543080
60MAP3K20.92316056
61FGFR10.92287288
62SGK20.87729660
63EPHA20.87306192
64ROCK20.84616802
65MAP2K30.83688469
66SGK30.82387614
67GSK3A0.81257024
68PDK20.80132149
69LATS20.79813665
70ERBB20.78498902
71MAPKAPK30.77456993
72PRKD10.76236725
73BMX0.75579100
74PRKAA20.74547043
75MAPK150.73368805
76PDK10.72403083
77EPHA30.71638719
78PAK20.71258030
79CAMK1D0.69381653
80MAP3K10.66855442
81CDK120.66499324
82PDK40.65347333
83PDK30.65347333
84TRPM70.64367659
85ADRBK20.63792053
86PINK10.63625526
87PLK20.62971580
88MATK0.62167865
89MUSK0.61884857
90EEF2K0.61799541
91IRAK10.61494308
92NLK0.61064565
93MTOR0.58580107
94MAP3K70.57540958
95NEK60.56607640
96MAP3K60.56334905
97SGK10.55875716
98WNK30.53753568
99IRAK20.52703848
100STK240.52173697
101MOS0.52160267
102FGFR30.51980005
103FGR0.51958479
104TGFBR20.51523826
105NTRK30.51123178
106PRKAA10.50541696
107MAPK110.50540702
108MAP3K50.49851978
109CAMK10.49107741
110CAMK1G0.49045599
111DYRK1B0.47207520
112CDC42BPA0.46618216
113FLT30.45935002
114MAP4K20.45926625
115RET0.45756254
116CSK0.44630065
117PRKCH0.44145926
118PRKD20.42805562
119DAPK20.42755196
120CHUK0.42207422
121MAPK70.42116545
122MAPK40.41653608
123ABL20.40489449
124CAMK2D0.40217586
125MAP2K10.38472139
126GRK10.38132235
127INSR0.37969132
128NTRK10.37874168
129MST40.37154313
130PDPK10.36467222
131SGK2230.35737933
132SGK4940.35737933
133CAMK2G0.35466091
134MAPK120.35295867
135PRKACG0.34135300
136NEK90.33779380
137RPS6KB20.32695434
138KDR0.32506112
139PRKD30.31939058
140JAK10.30965944

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.22637370
2Fatty acid degradation_Homo sapiens_hsa000712.91892480
3Nitrogen metabolism_Homo sapiens_hsa009102.66825996
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61674050
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61362310
6Fatty acid metabolism_Homo sapiens_hsa012122.50798913
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49251703
8Propanoate metabolism_Homo sapiens_hsa006402.46091549
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34604143
10Butanoate metabolism_Homo sapiens_hsa006502.29860641
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20770960
12Tryptophan metabolism_Homo sapiens_hsa003802.20625338
13PPAR signaling pathway_Homo sapiens_hsa033202.19256668
14Arginine biosynthesis_Homo sapiens_hsa002202.18379997
15Fatty acid elongation_Homo sapiens_hsa000622.14325067
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12050428
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03310333
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02699220
19Complement and coagulation cascades_Homo sapiens_hsa046102.00741557
20Peroxisome_Homo sapiens_hsa041461.88048933
21Steroid biosynthesis_Homo sapiens_hsa001001.85832716
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79240853
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58199463
24beta-Alanine metabolism_Homo sapiens_hsa004101.54468544
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54053951
26Chemical carcinogenesis_Homo sapiens_hsa052041.53602700
27Other glycan degradation_Homo sapiens_hsa005111.48737098
28Retinol metabolism_Homo sapiens_hsa008301.47708659
29Sulfur metabolism_Homo sapiens_hsa009201.46401891
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.45875303
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.43668973
32Histidine metabolism_Homo sapiens_hsa003401.41981515
33Pyruvate metabolism_Homo sapiens_hsa006201.41403413
34Phenylalanine metabolism_Homo sapiens_hsa003601.38040225
35ECM-receptor interaction_Homo sapiens_hsa045121.33762548
36Bile secretion_Homo sapiens_hsa049761.32873585
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31119246
38Fatty acid biosynthesis_Homo sapiens_hsa000611.30402866
39Fat digestion and absorption_Homo sapiens_hsa049751.29318862
40Tyrosine metabolism_Homo sapiens_hsa003501.24553402
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23126166
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21296054
43Carbon metabolism_Homo sapiens_hsa012001.21013598
44Pertussis_Homo sapiens_hsa051331.18885631
45Renin-angiotensin system_Homo sapiens_hsa046141.16407064
46Starch and sucrose metabolism_Homo sapiens_hsa005001.13619585
47Caffeine metabolism_Homo sapiens_hsa002321.12634957
48Lysine degradation_Homo sapiens_hsa003101.06253488
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04851337
50ABC transporters_Homo sapiens_hsa020101.03569313
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03520464
52Arginine and proline metabolism_Homo sapiens_hsa003300.98505946
53Malaria_Homo sapiens_hsa051440.96437027
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93933664
55Biosynthesis of amino acids_Homo sapiens_hsa012300.89651422
56Staphylococcus aureus infection_Homo sapiens_hsa051500.87106728
57Glycerolipid metabolism_Homo sapiens_hsa005610.83380317
58Renin secretion_Homo sapiens_hsa049240.82595411
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82525543
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81284643
61Glutathione metabolism_Homo sapiens_hsa004800.79551100
62Type II diabetes mellitus_Homo sapiens_hsa049300.79077386
63TNF signaling pathway_Homo sapiens_hsa046680.78816875
64Protein digestion and absorption_Homo sapiens_hsa049740.78433507
65Vitamin B6 metabolism_Homo sapiens_hsa007500.78135625
66Vitamin digestion and absorption_Homo sapiens_hsa049770.77328613
67Mineral absorption_Homo sapiens_hsa049780.77271553
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75735386
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.73182143
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72671335
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72219278
72Selenocompound metabolism_Homo sapiens_hsa004500.70675830
73Lysosome_Homo sapiens_hsa041420.70275982
74Focal adhesion_Homo sapiens_hsa045100.70000253
75Dilated cardiomyopathy_Homo sapiens_hsa054140.69612286
76Dorso-ventral axis formation_Homo sapiens_hsa043200.69318294
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.67817143
78African trypanosomiasis_Homo sapiens_hsa051430.63941452
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.63829805
80Tight junction_Homo sapiens_hsa045300.63469524
81Basal cell carcinoma_Homo sapiens_hsa052170.63326428
82Insulin resistance_Homo sapiens_hsa049310.63306598
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62932982
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61608670
85Linoleic acid metabolism_Homo sapiens_hsa005910.58540985
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.57459096
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.55773233
88Sulfur relay system_Homo sapiens_hsa041220.53787685
89Folate biosynthesis_Homo sapiens_hsa007900.51731918
90Circadian rhythm_Homo sapiens_hsa047100.49837425
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49521288
92Axon guidance_Homo sapiens_hsa043600.46867464
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46691901
94AMPK signaling pathway_Homo sapiens_hsa041520.45388718
95Hippo signaling pathway_Homo sapiens_hsa043900.42768215
96Ether lipid metabolism_Homo sapiens_hsa005650.42253158
97Bladder cancer_Homo sapiens_hsa052190.38298971
98Adherens junction_Homo sapiens_hsa045200.37816552
99Amoebiasis_Homo sapiens_hsa051460.37354956
100Ovarian steroidogenesis_Homo sapiens_hsa049130.37170127
101Thyroid hormone synthesis_Homo sapiens_hsa049180.35924386
102Proteoglycans in cancer_Homo sapiens_hsa052050.35415335
103Metabolic pathways_Homo sapiens_hsa011000.35135121
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34501576
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32898415
106Hedgehog signaling pathway_Homo sapiens_hsa043400.32459060
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.32198595
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32083269
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31791312
110Arachidonic acid metabolism_Homo sapiens_hsa005900.31034739
111Calcium signaling pathway_Homo sapiens_hsa040200.30923570
112Prion diseases_Homo sapiens_hsa050200.29960584
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29679996
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.29146923
115cAMP signaling pathway_Homo sapiens_hsa040240.28632880
116Glucagon signaling pathway_Homo sapiens_hsa049220.28201332
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27746430
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26255384
119Sphingolipid metabolism_Homo sapiens_hsa006000.25710602
120TGF-beta signaling pathway_Homo sapiens_hsa043500.24901412
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24001870
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20039107
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19781102
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.19439809
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19296492
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.19120150
127Cardiac muscle contraction_Homo sapiens_hsa042600.19085124
128Insulin signaling pathway_Homo sapiens_hsa049100.17581176

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