KANK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)6.45500295
2lymph vessel development (GO:0001945)6.25208931
3surfactant homeostasis (GO:0043129)6.18596786
4positive regulation of action potential (GO:0045760)6.14991624
5morphogenesis of an endothelium (GO:0003159)5.85415762
6endothelial tube morphogenesis (GO:0061154)5.85415762
7endothelium development (GO:0003158)5.63292807
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.22615518
9regulation of endothelial cell differentiation (GO:0045601)4.96079629
10chemical homeostasis within a tissue (GO:0048875)4.93540830
11blood vessel maturation (GO:0001955)4.81542715
12retina vasculature morphogenesis in camera-type eye (GO:0061299)4.80914459
13lymphangiogenesis (GO:0001946)4.69698949
14fatty acid transmembrane transport (GO:1902001)4.66617721
15positive regulation of vasculogenesis (GO:2001214)4.55232828
16carnitine shuttle (GO:0006853)4.54451017
17behavioral response to nicotine (GO:0035095)4.49433601
18basement membrane organization (GO:0071711)4.48106955
19heart trabecula formation (GO:0060347)4.43508615
20ovulation from ovarian follicle (GO:0001542)4.28912567
21regulation of vasculogenesis (GO:2001212)4.28364665
22sarcomere organization (GO:0045214)4.27076848
23cardiac myofibril assembly (GO:0055003)4.18956471
24regulation of action potential (GO:0098900)4.17160710
25positive regulation of protein kinase C signaling (GO:0090037)4.10006085
26patterning of blood vessels (GO:0001569)4.01330771
27neuronal action potential (GO:0019228)3.99825342
28endothelial cell differentiation (GO:0045446)3.95462245
29fusion of sperm to egg plasma membrane (GO:0007342)3.93905250
30positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.93566227
31plasma membrane repair (GO:0001778)3.93327875
32carnitine transmembrane transport (GO:1902603)3.91800580
33negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.86240870
34regulation of glycogen (starch) synthase activity (GO:2000465)3.84204052
35vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.81906790
36tricarboxylic acid cycle (GO:0006099)3.81841698
37blood vessel endothelial cell migration (GO:0043534)3.81086207
38cell migration involved in sprouting angiogenesis (GO:0002042)3.76497490
39low-density lipoprotein particle clearance (GO:0034383)3.72183635
40vasculogenesis (GO:0001570)3.68215484
41amino-acid betaine transport (GO:0015838)3.67755699
42carnitine transport (GO:0015879)3.67755699
43renal filtration (GO:0097205)3.64748260
44regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.60624500
45positive regulation of endothelial cell differentiation (GO:0045603)3.57496626
46endothelial cell morphogenesis (GO:0001886)3.57295455
47myofibril assembly (GO:0030239)3.56036976
48regulation of cell communication by electrical coupling (GO:0010649)3.52939702
49regulation of sequestering of triglyceride (GO:0010889)3.49530533
50glomerular filtration (GO:0003094)3.49248759
51regulation of p38MAPK cascade (GO:1900744)3.48641527
52bundle of His cell to Purkinje myocyte communication (GO:0086069)3.47527165
53positive regulation of sodium ion transmembrane transport (GO:1902307)3.47455356
54cardiac muscle cell development (GO:0055013)3.43175021
55histone H4-K12 acetylation (GO:0043983)3.42437692
56regulation of SMAD protein import into nucleus (GO:0060390)3.40997890
57response to dietary excess (GO:0002021)3.39746649
58muscle filament sliding (GO:0030049)3.36430728
59actin-myosin filament sliding (GO:0033275)3.36430728
60negative regulation of potassium ion transmembrane transport (GO:1901380)3.35590867
61embryonic heart tube development (GO:0035050)3.34497877
62venous blood vessel morphogenesis (GO:0048845)3.33503653
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33474596
64embryonic process involved in female pregnancy (GO:0060136)3.31267210
65endothelial cell chemotaxis (GO:0035767)3.30508483
66regulation of vascular permeability (GO:0043114)3.29487403
67positive regulation of SMAD protein import into nucleus (GO:0060391)3.29311591
68establishment of apical/basal cell polarity (GO:0035089)3.28151076
69cardiac cell development (GO:0055006)3.27233504
70trabecula morphogenesis (GO:0061383)3.26436449
71regulation of gene silencing by RNA (GO:0060966)3.23399415
72regulation of posttranscriptional gene silencing (GO:0060147)3.23399415
73regulation of gene silencing by miRNA (GO:0060964)3.23399415
74urinary tract smooth muscle contraction (GO:0014848)3.22463670
75adherens junction assembly (GO:0034333)3.18258313
76protein import into peroxisome matrix (GO:0016558)3.14286137
77phagocytosis, recognition (GO:0006910)3.13472551
78gamma-aminobutyric acid transport (GO:0015812)3.10310061
79negative regulation of nitric-oxide synthase activity (GO:0051001)3.07356050
80ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.05906083
81coronary vasculature morphogenesis (GO:0060977)3.01447694
82embryonic placenta development (GO:0001892)2.99812356
83piRNA metabolic process (GO:0034587)2.99546290
84cardiac muscle tissue morphogenesis (GO:0055008)2.95763618
85cAMP catabolic process (GO:0006198)2.95032079
86apoptotic process involved in morphogenesis (GO:0060561)2.94814118
87epithelial cell-cell adhesion (GO:0090136)2.92828910
88sprouting angiogenesis (GO:0002040)2.91377654
89regulation of cardioblast differentiation (GO:0051890)2.90796277
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90786559
91negative regulation of DNA biosynthetic process (GO:2000279)2.90750844
92positive regulation of p38MAPK cascade (GO:1900745)2.90595533
93cardiac muscle contraction (GO:0060048)2.89864371
94regulation of cholesterol storage (GO:0010885)2.87813103
95heart trabecula morphogenesis (GO:0061384)2.87272446
96plasma membrane fusion (GO:0045026)2.86051361
97cell-substrate junction assembly (GO:0007044)2.85598498
98negative regulation of blood vessel endothelial cell migration (GO:0043537)2.85398838
99quaternary ammonium group transport (GO:0015697)2.84509602
100regulation of phospholipid biosynthetic process (GO:0071071)2.84184261
101cell-substrate adherens junction assembly (GO:0007045)2.83953312
102focal adhesion assembly (GO:0048041)2.83953312
103regulation of acrosome reaction (GO:0060046)2.83189972
104blood vessel remodeling (GO:0001974)2.81642929
105response to mercury ion (GO:0046689)2.80119526
106regulation of tight junction assembly (GO:2000810)2.79515778
107regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.77786478
108actomyosin structure organization (GO:0031032)2.77522517
109regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.77452488
110neuron remodeling (GO:0016322)2.77293745
111regulation of skeletal muscle contraction (GO:0014819)2.76331796
112regulation of energy homeostasis (GO:2000505)2.74374514
113negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.74353577
114lipid particle organization (GO:0034389)2.72982932
115lung morphogenesis (GO:0060425)2.72250349
116negative regulation of activin receptor signaling pathway (GO:0032926)2.71334452
117sulfation (GO:0051923)2.70180279
118negative regulation of cell fate specification (GO:0009996)2.68121148
119ventricular trabecula myocardium morphogenesis (GO:0003222)2.67791126
120muscle tissue morphogenesis (GO:0060415)2.67064446
121glomerular visceral epithelial cell development (GO:0072015)2.66505137
122auditory behavior (GO:0031223)2.66141461
123positive regulation of fatty acid oxidation (GO:0046321)2.63347765
124negative regulation of vascular permeability (GO:0043116)2.63238821
125positive regulation of lipid storage (GO:0010884)2.62587910
126regulation of synapse structural plasticity (GO:0051823)2.62514950
127membrane depolarization during action potential (GO:0086010)2.62219955
128cAMP metabolic process (GO:0046058)2.62046160
129negative regulation of Rho protein signal transduction (GO:0035024)2.60994436
130regulation of the force of heart contraction (GO:0002026)2.60951557
131negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60081108
132cyclic nucleotide catabolic process (GO:0009214)2.57656907
133positive regulation of fatty acid beta-oxidation (GO:0032000)2.56836302
134angiogenesis involved in wound healing (GO:0060055)2.55958176
135behavioral response to ethanol (GO:0048149)2.49842415
136action potential (GO:0001508)2.49259865
137detection of light stimulus involved in visual perception (GO:0050908)2.48260739
138detection of light stimulus involved in sensory perception (GO:0050962)2.48260739
139cAMP biosynthetic process (GO:0006171)2.48239257
140serotonin metabolic process (GO:0042428)2.48203624
141dendritic spine morphogenesis (GO:0060997)2.47831849
142regulation of synapse maturation (GO:0090128)2.44119451
143artery development (GO:0060840)2.43139677
144positive regulation of sodium ion transport (GO:0010765)2.41598044
145somite development (GO:0061053)2.41293475
146toxin metabolic process (GO:0009404)2.40410123
147positive regulation of urine volume (GO:0035810)2.34327092
148protein-cofactor linkage (GO:0018065)2.33729736
149axon ensheathment in central nervous system (GO:0032291)2.31669840
150central nervous system myelination (GO:0022010)2.31669840
1513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.31385587
152purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.31385587
153regulation of sodium ion transmembrane transporter activity (GO:2000649)2.29975969
154detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.29728064
155regulation of triglyceride biosynthetic process (GO:0010866)2.29507741
156neuromuscular junction development (GO:0007528)2.28831606
157peristalsis (GO:0030432)2.28220800
158nucleotide transmembrane transport (GO:1901679)2.27026636
159regulation of protein kinase A signaling (GO:0010738)2.26946194
160positive regulation of triglyceride biosynthetic process (GO:0010867)2.26740435
161positive regulation of metanephros development (GO:0072216)2.26528146
162primary amino compound metabolic process (GO:1901160)2.25907725
163triglyceride catabolic process (GO:0019433)2.25709747
164renal tubule morphogenesis (GO:0061333)2.25634509
165DNA deamination (GO:0045006)2.24371752
166DNA methylation involved in gamete generation (GO:0043046)2.23966188
167cornea development in camera-type eye (GO:0061303)2.23587291
168negative regulation of protein oligomerization (GO:0032460)2.19679650
169synaptic transmission, cholinergic (GO:0007271)2.19341696
170positive regulation of protein targeting to membrane (GO:0090314)2.17951171
171adaptation of signaling pathway (GO:0023058)2.17307611
172nephron tubule morphogenesis (GO:0072078)2.16948205
173nephron epithelium morphogenesis (GO:0072088)2.16948205
174negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.16626431
175negative regulation of endothelial cell migration (GO:0010596)2.16242580
176spinal cord motor neuron differentiation (GO:0021522)2.15837115
177regulation of calcium ion-dependent exocytosis (GO:0017158)2.14452825
178positive regulation of glomerulus development (GO:0090193)2.13292839
179triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.13262534
180negative regulation of systemic arterial blood pressure (GO:0003085)2.12757279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.20686236
2EZH2_22144423_ChIP-Seq_EOC_Human5.21395047
3CLOCK_20551151_ChIP-Seq_293T_Human3.44202836
4ZNF263_19887448_ChIP-Seq_K562_Human3.23214473
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.22309353
6VDR_22108803_ChIP-Seq_LS180_Human3.19717055
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.96886051
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.88674486
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.88263275
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87098708
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.63943716
12STAT3_1855785_ChIP-Seq_MESCs_Mouse2.60308786
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.56859833
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.56051817
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.56051817
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.56051817
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.45859352
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.45472006
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45319516
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.40227375
21GBX2_23144817_ChIP-Seq_PC3_Human2.36381323
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.35823980
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35713583
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.34552819
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.30604326
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.29845549
27DROSHA_22980978_ChIP-Seq_HELA_Human2.28042752
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.27554475
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.24763545
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20907689
31EZH2_27304074_Chip-Seq_ESCs_Mouse2.19146568
32E2F7_22180533_ChIP-Seq_HELA_Human2.17330953
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14479307
34TBX20_22328084_ChIP-Seq_HEART_Mouse2.14256410
35TBX20_22080862_ChIP-Seq_HEART_Mouse2.14256410
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13799622
37TCF3_18692474_ChIP-Seq_MEFs_Mouse2.11052336
38EP300_21415370_ChIP-Seq_HL-1_Mouse2.10202514
39FOXM1_23109430_ChIP-Seq_U2OS_Human2.09366628
40EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07239925
41RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07239925
42ZNF274_21170338_ChIP-Seq_K562_Hela2.04007023
43JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02742036
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01924840
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95871630
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92193924
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.89880289
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.87942479
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87860347
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84655478
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83311484
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.82350994
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80974368
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79144156
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77560105
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.76786391
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75219451
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70640666
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69215451
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.67597679
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66138664
62TCF3_18692474_ChIP-Seq_MESCs_Mouse1.64378618
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.63950381
64REST_21632747_ChIP-Seq_MESCs_Mouse1.59835950
65* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57848361
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53891329
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53143955
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53050880
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51265713
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51042433
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48283611
72AR_21572438_ChIP-Seq_LNCaP_Human1.47421610
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.44360573
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43743641
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43617299
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42292931
77RACK7_27058665_Chip-Seq_MCF-7_Human1.40305519
78CTCF_27219007_Chip-Seq_Bcells_Human1.39989590
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.38785033
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.36864317
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.36442692
82BCAT_22108803_ChIP-Seq_LS180_Human1.35164683
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.34910925
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32405574
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31448845
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31405417
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30964761
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30866772
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30748413
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30358065
91NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28346925
92KDM2B_26808549_Chip-Seq_DND41_Human1.28046563
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26279819
94TCF7_22412390_ChIP-Seq_EML_Mouse1.26275405
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25695227
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24786826
97* RNF2_27304074_Chip-Seq_NSC_Mouse1.23036807
98ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22843161
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21867144
100* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21592952
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.21088195
102* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20642382
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19350903
104IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18846774
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18381861
106LXR_22292898_ChIP-Seq_THP-1_Human1.17928149
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17500838
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17101623
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15310940
110GATA1_19941826_ChIP-Seq_K562_Human1.15202139
111IGF1R_20145208_ChIP-Seq_DFB_Human1.15003487
112ATF3_27146783_Chip-Seq_COLON_Human1.12670358
113* ERA_21632823_ChIP-Seq_H3396_Human1.12372291
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.11157956
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11116763
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09295673
117SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09123658
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07405109
119NCOR1_26117541_ChIP-Seq_K562_Human1.07369256
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.07329645
121TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06893930
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06725047
123NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06301952
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.05939276
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.05485209
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05405418
127MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02938976
128PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02870377
129NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01914310
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01512599
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00590188
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98517653
133TAF2_19829295_ChIP-Seq_ESCs_Human0.98509536
134PIAS1_25552417_ChIP-Seq_VCAP_Human0.98050507
135MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96802317
136MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96698944
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94793231
138AHR_22903824_ChIP-Seq_MCF-7_Human0.94792782
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94763480
140NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94384609
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94344186
142AR_25329375_ChIP-Seq_VCAP_Human0.94260780
143LXR_22158963_ChIP-Seq_LIVER_Mouse0.93642254
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93609124
145GATA3_21878914_ChIP-Seq_MCF-7_Human0.93511012
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93096260
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92125005
148TAF15_26573619_Chip-Seq_HEK293_Human0.90830879
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90702130
150P300_19829295_ChIP-Seq_ESCs_Human0.90490613
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90377351
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90248832
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90076248
154* E2F1_20622854_ChIP-Seq_HELA_Human0.90045777
155* P68_20966046_ChIP-Seq_HELA_Human0.89548378
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89428595
157TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89415926
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89393887
159SPI1_20517297_ChIP-Seq_HL60_Human0.89367990
160RXR_22108803_ChIP-Seq_LS180_Human0.88574080
161ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88495387
162POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.87818808
163* KDM2B_26808549_Chip-Seq_K562_Human0.87644009
164SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87556686
165POU5F1_16518401_ChIP-PET_MESCs_Mouse0.87345055
166SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87093988
167SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87093988
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87009738
169ESR1_20079471_ChIP-ChIP_T-47D_Human0.86747184
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86589027
171KLF4_19829295_ChIP-Seq_ESCs_Human0.86055419
172SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85656505
173FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85577219
174RUNX2_22187159_ChIP-Seq_PCA_Human0.85202987
175OCT4_20526341_ChIP-Seq_ESCs_Human0.84660065
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84043886
177STAT3_23295773_ChIP-Seq_U87_Human0.83427088
178MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83262367
179EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83192146
180SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82675314
181MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82144306
182RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.82083437
183TCF4_23295773_ChIP-Seq_U87_Human0.81022754
184TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80895702
185POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80895702
186ER_23166858_ChIP-Seq_MCF-7_Human0.80580661
187RAC3_21632823_ChIP-Seq_H3396_Human0.79827027
188* RING1B_27294783_Chip-Seq_NPCs_Mouse0.78922109
189EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78429028
190TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78358737
191LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78350296

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.74049997
2MP0005167_abnormal_blood-brain_barrier4.52232725
3MP0004084_abnormal_cardiac_muscle4.08742753
4MP0001879_abnormal_lymphatic_vessel3.93052241
5MP0004272_abnormal_basement_membrane3.36128665
6MP0005670_abnormal_white_adipose3.03137192
7MP0003828_pulmonary_edema2.92160693
8MP0003136_yellow_coat_color2.87288719
9MP0000751_myopathy2.77196087
10MP0004036_abnormal_muscle_relaxation2.65399468
11MP0002837_dystrophic_cardiac_calcinosis2.60564714
12MP0002876_abnormal_thyroid_physiology2.53157585
13MP0005330_cardiomyopathy2.47556199
14MP0004215_abnormal_myocardial_fiber2.47015100
15MP0009278_abnormal_bone_marrow2.39534898
16MP0006138_congestive_heart_failure2.33492448
17MP0003705_abnormal_hypodermis_morpholog2.20217620
18MP0003950_abnormal_plasma_membrane2.19567025
19MP0003011_delayed_dark_adaptation2.15037139
20MP0003646_muscle_fatigue2.12532488
21MP0008775_abnormal_heart_ventricle2.11814768
22MP0002332_abnormal_exercise_endurance2.08841909
23MP0001986_abnormal_taste_sensitivity2.08086842
24MP0010630_abnormal_cardiac_muscle2.04780880
25MP0005385_cardiovascular_system_phenoty2.00540011
26MP0001544_abnormal_cardiovascular_syste2.00540011
27MP0004130_abnormal_muscle_cell1.96459959
28MP0003566_abnormal_cell_adhesion1.93238181
29MP0000749_muscle_degeneration1.92466876
30MP0004087_abnormal_muscle_fiber1.91002253
31MP0003191_abnormal_cellular_cholesterol1.85312304
32MP0005666_abnormal_adipose_tissue1.81377066
33MP0004484_altered_response_of1.78540036
34MP0004147_increased_porphyrin_level1.78248838
35MP0000750_abnormal_muscle_regeneration1.78020452
36MP0002638_abnormal_pupillary_reflex1.75557347
37MP0002127_abnormal_cardiovascular_syste1.73546381
38MP0002972_abnormal_cardiac_muscle1.70450271
39MP0003279_aneurysm1.70277413
40MP0005623_abnormal_meninges_morphology1.66523526
41MP0004885_abnormal_endolymph1.64716124
42MP0000343_altered_response_to1.63054561
43MP0005620_abnormal_muscle_contractility1.59049244
44MP0005171_absent_coat_pigmentation1.57133750
45MP0009745_abnormal_behavioral_response1.51545006
46MP0002254_reproductive_system_inflammat1.49924087
47MP0000767_abnormal_smooth_muscle1.48393840
48MP0005551_abnormal_eye_electrophysiolog1.43244654
49MP0005174_abnormal_tail_pigmentation1.41932089
50MP0008995_early_reproductive_senescence1.41312190
51MP0004085_abnormal_heartbeat1.39988033
52MP0005423_abnormal_somatic_nervous1.38127945
53MP0001958_emphysema1.37202605
54MP0002269_muscular_atrophy1.36915849
55MP0002106_abnormal_muscle_physiology1.36148252
56MP0003567_abnormal_fetal_cardiomyocyte1.34638696
57MP0002064_seizures1.34065039
58MP0000249_abnormal_blood_vessel1.32884880
59MP0005410_abnormal_fertilization1.32456374
60MP0005165_increased_susceptibility_to1.32391179
61MP0002925_abnormal_cardiovascular_devel1.31877158
62MP0004185_abnormal_adipocyte_glucose1.31653455
63MP0002272_abnormal_nervous_system1.28852182
64MP0006276_abnormal_autonomic_nervous1.27576549
65MP0005375_adipose_tissue_phenotype1.25838046
66MP0002733_abnormal_thermal_nociception1.24127662
67MP0000266_abnormal_heart_morphology1.23064204
68MP0005397_hematopoietic_system_phenotyp1.22675480
69MP0001545_abnormal_hematopoietic_system1.22675480
70MP0002128_abnormal_blood_circulation1.22302732
71MP0003195_calcinosis1.21763899
72MP0010030_abnormal_orbit_morphology1.21474204
73MP0005448_abnormal_energy_balance1.20293889
74MP0002933_joint_inflammation1.19089766
75MP0008961_abnormal_basal_metabolism1.18642252
76MP0004510_myositis1.18615620
77MP0003724_increased_susceptibility_to1.18605036
78MP0003221_abnormal_cardiomyocyte_apopto1.18448730
79MP0002295_abnormal_pulmonary_circulatio1.14088022
80MP0009046_muscle_twitch1.12880435
81MP0001970_abnormal_pain_threshold1.11059739
82MP0001614_abnormal_blood_vessel1.10422216
83MP0001873_stomach_inflammation1.09523787
84MP0005503_abnormal_tendon_morphology1.08062399
85MP0000759_abnormal_skeletal_muscle1.07073569
86MP0002572_abnormal_emotion/affect_behav1.06875602
87MP0008438_abnormal_cutaneous_collagen1.06873340
88MP0003984_embryonic_growth_retardation1.03995622
89MP0005369_muscle_phenotype1.03711916
90MP0001968_abnormal_touch/_nociception1.03478848
91MP0002088_abnormal_embryonic_growth/wei1.01857983
92MP0005595_abnormal_vascular_smooth1.01764021
93MP0010329_abnormal_lipoprotein_level1.01206936
94MP0000049_abnormal_middle_ear1.01167260
95MP0005409_darkened_coat_color1.00293660
96MP0002086_abnormal_extraembryonic_tissu0.99973761
97MP0008877_abnormal_DNA_methylation0.99244372
98MP0002138_abnormal_hepatobiliary_system0.98906223
99MP0004782_abnormal_surfactant_physiolog0.97978806
100MP0004142_abnormal_muscle_tone0.97774346
101MP0000778_abnormal_nervous_system0.97517772
102MP0003635_abnormal_synaptic_transmissio0.97027177
103MP0003091_abnormal_cell_migration0.94799695
104MP0003137_abnormal_impulse_conducting0.93955570
105MP0002063_abnormal_learning/memory/cond0.92375363
106MP0004145_abnormal_muscle_electrophysio0.92357725
107MP0001502_abnormal_circadian_rhythm0.91678069
108MP0005084_abnormal_gallbladder_morpholo0.90569105
109MP0003283_abnormal_digestive_organ0.89411647
110MP0009379_abnormal_foot_pigmentation0.89231623
111MP0001672_abnormal_embryogenesis/_devel0.88460291
112MP0005380_embryogenesis_phenotype0.88460291
113MP0000013_abnormal_adipose_tissue0.88027103
114MP0003959_abnormal_lean_body0.87949715
115MP0004233_abnormal_muscle_weight0.87287531
116MP0006054_spinal_hemorrhage0.84864105
117MP0006036_abnormal_mitochondrial_physio0.83784135
118MP0000026_abnormal_inner_ear0.82862605
119MP0003879_abnormal_hair_cell0.81515170
120MP0005365_abnormal_bile_salt0.80774571
121MP0000747_muscle_weakness0.80458291
122MP0001501_abnormal_sleep_pattern0.78750854
123MP0001486_abnormal_startle_reflex0.78465049
124MP0001730_embryonic_growth_arrest0.78217173
125MP0001440_abnormal_grooming_behavior0.76879892
126MP0002102_abnormal_ear_morphology0.76830732
127MP0005195_abnormal_posterior_eye0.76007258
128MP0000631_abnormal_neuroendocrine_gland0.75410067
129MP0001784_abnormal_fluid_regulation0.75101307
130MP0010352_gastrointestinal_tract_polyps0.74721674
131MP0005266_abnormal_metabolism0.74415817
132MP0004133_heterotaxia0.72986370
133MP0004883_abnormal_blood_vessel0.72802769
134MP0000465_gastrointestinal_hemorrhage0.72165816
135MP0001485_abnormal_pinna_reflex0.72142196
136MP0002734_abnormal_mechanical_nocicepti0.72034963
137MP0000003_abnormal_adipose_tissue0.71629601
138MP0005388_respiratory_system_phenotype0.71096978
139MP0002133_abnormal_respiratory_system0.71096978
140MP0003941_abnormal_skin_development0.71073438
141MP0002067_abnormal_sensory_capabilities0.70420661
142MP0004858_abnormal_nervous_system0.69863939
143MP0005253_abnormal_eye_physiology0.69471319
144MP0004808_abnormal_hematopoietic_stem0.69369120
145MP0002928_abnormal_bile_duct0.69308502
146MP0005164_abnormal_response_to0.68327420
147MP0002971_abnormal_brown_adipose0.68026732
148MP0002108_abnormal_muscle_morphology0.67761519
149MP0005535_abnormal_body_temperature0.67555007
150MP0005076_abnormal_cell_differentiation0.67031736
151MP0001664_abnormal_digestion0.66371403
152MP0000230_abnormal_systemic_arterial0.63270007
153MP0001175_abnormal_lung_morphology0.62353186
154MP0001915_intracranial_hemorrhage0.62322954
155MP0000733_abnormal_muscle_development0.61812613
156MP0005319_abnormal_enzyme/_coenzyme0.57622058

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)5.24160857
2Exercise-induced muscle cramps (HP:0003710)4.78042383
3Sudden death (HP:0001699)4.66653933
4Increased connective tissue (HP:0009025)4.56364848
5Hematochezia (HP:0002573)4.55821386
6Ventricular tachycardia (HP:0004756)4.54504316
7Abnormality of the nasal mucosa (HP:0000433)4.54274547
8Muscle fiber splitting (HP:0003555)4.49460381
9Myoglobinuria (HP:0002913)4.32626264
10Atrial fibrillation (HP:0005110)4.07370318
11Hyporeflexia of lower limbs (HP:0002600)3.98403449
12Difficulty running (HP:0009046)3.85397608
13Supraventricular arrhythmia (HP:0005115)3.85317124
14Congenital stationary night blindness (HP:0007642)3.85247094
15Spontaneous hematomas (HP:0007420)3.83418629
16Primary atrial arrhythmia (HP:0001692)3.80346465
17Supraventricular tachycardia (HP:0004755)3.67965128
18Esophageal varix (HP:0002040)3.62022389
19Molar tooth sign on MRI (HP:0002419)3.56742570
20Abnormality of midbrain morphology (HP:0002418)3.56742570
21Exercise-induced myalgia (HP:0003738)3.51021493
22Right ventricular cardiomyopathy (HP:0011663)3.45645555
23Rhabdomyolysis (HP:0003201)3.39021853
24Difficulty climbing stairs (HP:0003551)3.37973397
25Cerebral aneurysm (HP:0004944)3.37839037
26Lipoatrophy (HP:0100578)3.35970154
27Pancreatic cysts (HP:0001737)3.29883455
28Large for gestational age (HP:0001520)3.26540060
29Atrioventricular block (HP:0001678)3.25458621
30Genetic anticipation (HP:0003743)3.02299886
31Calf muscle hypertrophy (HP:0008981)3.00853810
32Conjunctival telangiectasia (HP:0000524)2.98907326
33Asymmetric septal hypertrophy (HP:0001670)2.96618337
34Myotonia (HP:0002486)2.96597007
35Bundle branch block (HP:0011710)2.92285945
36Pancreatic fibrosis (HP:0100732)2.91043873
37Adactyly (HP:0009776)2.88437303
38Lymphangioma (HP:0100764)2.86748733
39Mesangial abnormality (HP:0001966)2.86124611
40Distal lower limb muscle weakness (HP:0009053)2.85912534
41Nephronophthisis (HP:0000090)2.85663810
42Testicular atrophy (HP:0000029)2.82863308
43Muscle stiffness (HP:0003552)2.81533316
44Abnormal drinking behavior (HP:0030082)2.79310354
45Polydipsia (HP:0001959)2.79310354
46Heart block (HP:0012722)2.78296969
47True hermaphroditism (HP:0010459)2.77778112
48Abnormality of the vasculature of the conjunctiva (HP:0008054)2.76979225
49Limb dystonia (HP:0002451)2.76213657
50Muscle hypertrophy of the lower extremities (HP:0008968)2.73776860
51Progressive cerebellar ataxia (HP:0002073)2.71710065
52Hypoglycemic coma (HP:0001325)2.67601196
53Decreased circulating renin level (HP:0003351)2.64593022
54Abnormal atrioventricular conduction (HP:0005150)2.62048774
55Prolonged QT interval (HP:0001657)2.61360060
56Hemiplegia (HP:0002301)2.60784941
57Dilated cardiomyopathy (HP:0001644)2.60689616
58Visceral angiomatosis (HP:0100761)2.59376299
59Chronic hepatic failure (HP:0100626)2.59149739
60Pendular nystagmus (HP:0012043)2.58045783
61EMG: myopathic abnormalities (HP:0003458)2.57564516
62Oligomenorrhea (HP:0000876)2.57410101
63Bulbous nose (HP:0000414)2.55645599
64Hemangiomatosis (HP:0007461)2.53614075
65Syncope (HP:0001279)2.52437665
66Prominent supraorbital ridges (HP:0000336)2.49954899
67Generalized muscle weakness (HP:0003324)2.49356351
68Polyphagia (HP:0002591)2.49088292
69Cystic liver disease (HP:0006706)2.46396372
70Cerebral hemorrhage (HP:0001342)2.45423133
71Increased variability in muscle fiber diameter (HP:0003557)2.45061523
72Nonimmune hydrops fetalis (HP:0001790)2.43302813
73Rectal prolapse (HP:0002035)2.43130326
74Delayed CNS myelination (HP:0002188)2.42471971
75Inability to walk (HP:0002540)2.41513795
76Abnormality of the calf musculature (HP:0001430)2.41116864
77Hyperlipoproteinemia (HP:0010980)2.38494537
78Abnormality of skeletal muscle fiber size (HP:0012084)2.37279391
79Hyperventilation (HP:0002883)2.36045034
80Palpitations (HP:0001962)2.35738818
81Abnormality of the left ventricular outflow tract (HP:0011103)2.35375101
82Subaortic stenosis (HP:0001682)2.35375101
83Spinal rigidity (HP:0003306)2.34618598
84Facial diplegia (HP:0001349)2.32797917
85Abnormality of the renal medulla (HP:0100957)2.31736777
86Febrile seizures (HP:0002373)2.31078288
87Rib fusion (HP:0000902)2.29424321
88Focal motor seizures (HP:0011153)2.29415239
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.28672293
90Hypoplastic ischia (HP:0003175)2.28529807
91Tubular atrophy (HP:0000092)2.28193941
92Hemiparesis (HP:0001269)2.27818817
93Pulmonary artery stenosis (HP:0004415)2.26927892
94Tachypnea (HP:0002789)2.25715995
95Decreased central vision (HP:0007663)2.25073369
96Abnormality of the ischium (HP:0003174)2.21813837
97Maternal diabetes (HP:0009800)2.21189581
98Type II lissencephaly (HP:0007260)2.20853634
99Acanthosis nigricans (HP:0000956)2.20699071
100Broad metatarsal (HP:0001783)2.20489459
101Nasal polyposis (HP:0100582)2.19096039
102Hemorrhage of the eye (HP:0011885)2.17962432
103Congenital hepatic fibrosis (HP:0002612)2.17735896
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.17620023
105Absent/shortened dynein arms (HP:0200106)2.17620023
106Areflexia of lower limbs (HP:0002522)2.17567304
107Ulnar claw (HP:0001178)2.16040686
108Polyuria (HP:0000103)2.13810676
109Portal hypertension (HP:0001409)2.13006619
110Absent hand (HP:0004050)2.12190244
111Brushfield spots (HP:0001088)2.12166876
112Attenuation of retinal blood vessels (HP:0007843)2.12075490
113Hip contracture (HP:0003273)2.11869808
114Ventricular arrhythmia (HP:0004308)2.10939700
115Chorioretinal atrophy (HP:0000533)2.10351078
116Short hallux (HP:0010109)2.09420717
117Neonatal death (HP:0003811)2.08485330
118Increased corneal curvature (HP:0100692)2.06932095
119Keratoconus (HP:0000563)2.06932095
120Focal seizures (HP:0007359)2.06802536
121Abnormality of the lower motor neuron (HP:0002366)2.06556839
122Renal salt wasting (HP:0000127)2.05805710
123Abnormality of the vertebral endplates (HP:0005106)2.05710123
124Pigmentary retinal degeneration (HP:0001146)2.04119382
125Skull defect (HP:0001362)2.03318133
126Bronchomalacia (HP:0002780)2.01187021
127Aneurysm (HP:0002617)1.99769319
128Stroke (HP:0001297)1.99015737
129Hyperglycinuria (HP:0003108)1.98636511
130Shawl scrotum (HP:0000049)1.98513688
131EMG: neuropathic changes (HP:0003445)1.97965628
132Abnormal eating behavior (HP:0100738)1.97549391
133Abnormality of the hepatic vasculature (HP:0006707)1.97374795
134Hyperkalemia (HP:0002153)1.96970337
135Severe muscular hypotonia (HP:0006829)1.96430210
136Multiple enchondromatosis (HP:0005701)1.96161137
137Broad-based gait (HP:0002136)1.93502935
138Muscular dystrophy (HP:0003560)1.93426023
139Congenital sensorineural hearing impairment (HP:0008527)1.93330445
140Porencephaly (HP:0002132)1.92738730
141Progressive muscle weakness (HP:0003323)1.92570542
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.91639839
143Concave nail (HP:0001598)1.90922059
144Ependymoma (HP:0002888)1.89973052
145Short 4th metacarpal (HP:0010044)1.89301928
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89301928
147Hyperactive renin-angiotensin system (HP:0000841)1.87420654
148Furrowed tongue (HP:0000221)1.86669927
149Bony spicule pigmentary retinopathy (HP:0007737)1.85015196
150Hand muscle atrophy (HP:0009130)1.84132988
151Cavernous hemangioma (HP:0001048)1.83582666
152Bone cyst (HP:0012062)1.83511279
153Abnormal urine output (HP:0012590)1.82730285
154Abnormal EKG (HP:0003115)1.82614535
155Short humerus (HP:0005792)1.82129836
156Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81515187
157Abnormality of alanine metabolism (HP:0010916)1.81515187
158Hyperalaninemia (HP:0003348)1.81515187
159Congenital, generalized hypertrichosis (HP:0004540)1.81028402
160Ragged-red muscle fibers (HP:0003200)1.80937355
161Abnormality of the renal collecting system (HP:0004742)1.80285630
162Aplasia/Hypoplasia of the hallux (HP:0008362)1.79531154
163Chronic bronchitis (HP:0004469)1.79508399
164High pitched voice (HP:0001620)1.76262838
165Mucosal telangiectasiae (HP:0100579)1.74896343
166Distal upper limb amyotrophy (HP:0007149)1.74700948
167Upper limb amyotrophy (HP:0009129)1.74700948
168Hypertriglyceridemia (HP:0002155)1.74574475
169Type 1 muscle fiber predominance (HP:0003803)1.73781707
170Atonic seizures (HP:0010819)1.73755393
171Preaxial foot polydactyly (HP:0001841)1.73748501
172Ankle contracture (HP:0006466)1.73279116
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.71879080
174Short chin (HP:0000331)1.71820534
175Abnormal ciliary motility (HP:0012262)1.71679596
176Abnormality of the renal cortex (HP:0011035)1.70447176
177Anencephaly (HP:0002323)1.68721340
178Duplicated collecting system (HP:0000081)1.68572666
179Left ventricular hypertrophy (HP:0001712)1.68566904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE17.62453121
2KDR5.10463358
3TGFBR23.34371565
4PDK33.24801187
5PDK43.24801187
6TTN3.06170625
7MAPK152.99677946
8PDK22.86633563
9ADRBK22.61358888
10PKN22.43440491
11MYLK2.42069594
12SIK22.41501466
13FRK2.34873199
14PNCK2.26012643
15RIPK12.23578355
16NTRK32.16265149
17TRIB32.12967816
18EPHA22.06202176
19TGFBR12.02875954
20MARK12.01259777
21PASK2.00739276
22TLK11.99886637
23CDK121.91895660
24PTK2B1.83075693
25BMPR1B1.82981873
26GRK11.74434371
27PAK41.71079248
28BCKDK1.67898676
29EPHB21.56688263
30OBSCN1.55366249
31ERN11.52644417
32MAPK131.46540691
33TAOK31.43755449
34NEK11.40784233
35PRKD31.37120689
36MAP3K131.36852625
37DMPK1.23660878
38MAP2K31.19763554
39MUSK1.17741717
40PKN11.16773300
41ADRBK11.16054019
42PHKG11.14918010
43PHKG21.14918010
44CAMKK11.13328349
45LMTK21.13219294
46DAPK21.10856587
47ICK1.10573394
48PDGFRA1.09213647
49CAMK11.08238714
50PINK11.07955335
51CASK1.00523303
52FER0.95409789
53PRKG20.94663398
54RPS6KA60.94419914
55RPS6KA20.94348807
56WNK40.94159893
57STK390.93716991
58CAMK1D0.90897449
59ACVR1B0.90476233
60CAMKK20.89284888
61NUAK10.87281949
62PTK60.85979009
63AKT30.84515034
64PRKD10.82563498
65FES0.82063705
66ITK0.79774745
67ZAK0.78082325
68NTRK20.75794457
69MAPKAPK30.75428333
70CDK90.73189390
71INSRR0.71958064
72TNK20.71762789
73WNK30.71418145
74WEE10.70572472
75LRRK20.69423776
76MAP3K110.68686597
77NEK20.67920187
78CSK0.66506874
79MAPK120.64697830
80RPS6KA50.63855785
81CDK60.63438056
82NLK0.62423612
83DYRK20.62042373
84FLT30.61628354
85PRKCG0.61559160
86TESK10.60742223
87MAPKAPK50.60649714
88MAP2K20.59971415
89PRKAA20.57988353
90MAP3K30.57083772
91DAPK30.56753687
92MTOR0.56149698
93ERBB20.55949713
94PIK3CG0.55854525
95RPS6KC10.55062328
96RPS6KL10.55062328
97FGFR40.54572747
98NTRK10.54491309
99SGK2230.53150037
100SGK4940.53150037
101MET0.52962187
102SIK10.52649042
103TTK0.52531164
104MARK30.51837379
105OXSR10.50994341
106GRK50.49440821
107PAK30.48824413
108CDC42BPA0.48540094
109PRKACA0.47983646
110STK380.47870858
111ILK0.47689658
112CAMK2A0.46969661
113SGK20.46381004
114PRKCE0.45996806
115STK100.44822105
116MAP2K60.44214907
117MAP2K10.43611254
118MAPK40.43002197
119PRKG10.42535027
120STK40.41863322
121KIT0.41635397
122PRKCZ0.41009177
123CDK40.40526863
124TRPM70.40476061
125PAK20.39338400
126WNK10.38633895
127GSK3A0.38469245
128PTK20.38288318
129PIM10.37993324
130PIK3CA0.37783351
131BRD40.37715216
132TYRO30.37540926
133PRKCQ0.37279697
134NME10.36918091
135MAP3K70.36495146
136CAMK40.36155941
137CAMK1G0.36110058
138PDPK10.35889905
139AKT20.35063871
140STK110.34713745
141CDK70.32375554
142LATS20.32254413
143PRKAA10.30657884
144MARK20.29911302
145EPHB10.29514832
146NME20.29496123
147ROCK10.28915973
148TYK20.28370323
149LATS10.28009715
150MAP3K80.27751158
151BMX0.25958971
152PDK10.25250088
153IGF1R0.24686977
154ALK0.24089620
155EGFR0.23370595
156RPS6KB20.22899453
157MAPK70.22395439
158TSSK60.21891198
159SRC0.20801911
160PRKCH0.20377144
161STK30.18255463
162DYRK30.18246662
163AURKB0.17560238

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.69049594
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.73574850
3Propanoate metabolism_Homo sapiens_hsa006402.99887000
4Fatty acid degradation_Homo sapiens_hsa000712.86969621
5Dilated cardiomyopathy_Homo sapiens_hsa054142.53715445
6Sulfur relay system_Homo sapiens_hsa041222.34591670
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.34559270
8Carbon metabolism_Homo sapiens_hsa012002.29197358
9Fatty acid metabolism_Homo sapiens_hsa012122.24892306
10PPAR signaling pathway_Homo sapiens_hsa033202.23594722
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17172637
12Cardiac muscle contraction_Homo sapiens_hsa042602.17071332
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16779102
14Nicotine addiction_Homo sapiens_hsa050332.08287475
15Fatty acid biosynthesis_Homo sapiens_hsa000612.05367156
16Taste transduction_Homo sapiens_hsa047421.97870247
17Adherens junction_Homo sapiens_hsa045201.97662572
18Morphine addiction_Homo sapiens_hsa050321.95875282
19Linoleic acid metabolism_Homo sapiens_hsa005911.95469712
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92427360
21Phototransduction_Homo sapiens_hsa047441.84816580
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80726561
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78213500
24Pyruvate metabolism_Homo sapiens_hsa006201.76634885
25ABC transporters_Homo sapiens_hsa020101.74854961
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74485284
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.73176877
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69119435
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66864888
30ECM-receptor interaction_Homo sapiens_hsa045121.64875233
31Focal adhesion_Homo sapiens_hsa045101.60792052
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58837884
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.47706340
34HIF-1 signaling pathway_Homo sapiens_hsa040661.46515351
35Histidine metabolism_Homo sapiens_hsa003401.41322167
36Cocaine addiction_Homo sapiens_hsa050301.40881412
37Insulin secretion_Homo sapiens_hsa049111.38875914
38Tight junction_Homo sapiens_hsa045301.37083671
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.34742639
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33025375
41Circadian entrainment_Homo sapiens_hsa047131.31663584
42Biosynthesis of amino acids_Homo sapiens_hsa012301.27515818
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25389670
44GABAergic synapse_Homo sapiens_hsa047271.22520427
45Glucagon signaling pathway_Homo sapiens_hsa049221.22076447
46Small cell lung cancer_Homo sapiens_hsa052221.21643163
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20396757
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19862486
49Insulin resistance_Homo sapiens_hsa049311.16473879
50Notch signaling pathway_Homo sapiens_hsa043301.13895707
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13720685
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13152668
53Glutamatergic synapse_Homo sapiens_hsa047241.12680801
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12589691
55Arginine biosynthesis_Homo sapiens_hsa002201.11133650
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10443689
57Ether lipid metabolism_Homo sapiens_hsa005651.09922508
58Axon guidance_Homo sapiens_hsa043601.09000195
59Bile secretion_Homo sapiens_hsa049761.08681248
60Viral myocarditis_Homo sapiens_hsa054161.07777433
61Butanoate metabolism_Homo sapiens_hsa006501.05331678
62Fructose and mannose metabolism_Homo sapiens_hsa000511.04385289
63Glycerolipid metabolism_Homo sapiens_hsa005611.03640336
64Dorso-ventral axis formation_Homo sapiens_hsa043201.03289953
65Olfactory transduction_Homo sapiens_hsa047401.00196145
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00002853
67AMPK signaling pathway_Homo sapiens_hsa041520.99265123
68Rap1 signaling pathway_Homo sapiens_hsa040150.99164871
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.98868744
70Renin secretion_Homo sapiens_hsa049240.95913590
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.94470252
72Serotonergic synapse_Homo sapiens_hsa047260.93833996
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93739787
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93479307
75Vitamin digestion and absorption_Homo sapiens_hsa049770.92677829
76Tyrosine metabolism_Homo sapiens_hsa003500.92573912
77Lysine degradation_Homo sapiens_hsa003100.89624874
78Oxidative phosphorylation_Homo sapiens_hsa001900.87744977
79VEGF signaling pathway_Homo sapiens_hsa043700.86120000
80Chemical carcinogenesis_Homo sapiens_hsa052040.86045585
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85032967
82Amoebiasis_Homo sapiens_hsa051460.84452498
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.82387744
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81962185
85Caffeine metabolism_Homo sapiens_hsa002320.81624539
86Circadian rhythm_Homo sapiens_hsa047100.81055407
87Hedgehog signaling pathway_Homo sapiens_hsa043400.80623342
88Cholinergic synapse_Homo sapiens_hsa047250.78643236
89Insulin signaling pathway_Homo sapiens_hsa049100.76588922
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.74983563
91Retinol metabolism_Homo sapiens_hsa008300.74901899
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.74509379
93Parkinsons disease_Homo sapiens_hsa050120.74361580
94Proteoglycans in cancer_Homo sapiens_hsa052050.74161878
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73643678
96MAPK signaling pathway_Homo sapiens_hsa040100.72655106
97Arachidonic acid metabolism_Homo sapiens_hsa005900.72347224
98Huntingtons disease_Homo sapiens_hsa050160.71716532
99Phenylalanine metabolism_Homo sapiens_hsa003600.69438977
100Nitrogen metabolism_Homo sapiens_hsa009100.69405251
101Platelet activation_Homo sapiens_hsa046110.67680517
102TGF-beta signaling pathway_Homo sapiens_hsa043500.67581110
103Regulation of autophagy_Homo sapiens_hsa041400.66525662
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66200385
105Hippo signaling pathway_Homo sapiens_hsa043900.65676831
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65564532
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65044126
108Protein digestion and absorption_Homo sapiens_hsa049740.64345995
109Pathways in cancer_Homo sapiens_hsa052000.62122916
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61872651
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61423017
112Selenocompound metabolism_Homo sapiens_hsa004500.60542178
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60247199
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59941827
115Amphetamine addiction_Homo sapiens_hsa050310.59642181
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59028830
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59022422
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57496183
119Dopaminergic synapse_Homo sapiens_hsa047280.57347328
120Ras signaling pathway_Homo sapiens_hsa040140.56924487
121Tryptophan metabolism_Homo sapiens_hsa003800.55637126
122Gap junction_Homo sapiens_hsa045400.54680747
123Melanogenesis_Homo sapiens_hsa049160.54581785
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53218649
125Fat digestion and absorption_Homo sapiens_hsa049750.50867955
126Pentose phosphate pathway_Homo sapiens_hsa000300.50107574
127Toxoplasmosis_Homo sapiens_hsa051450.48316564
128Oocyte meiosis_Homo sapiens_hsa041140.47541522
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47008804
130Ovarian steroidogenesis_Homo sapiens_hsa049130.45642962
131Oxytocin signaling pathway_Homo sapiens_hsa049210.45463076
132beta-Alanine metabolism_Homo sapiens_hsa004100.45274849
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.45065923
134Peroxisome_Homo sapiens_hsa041460.44852880
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44357984
136Thyroid cancer_Homo sapiens_hsa052160.43876483
137Mineral absorption_Homo sapiens_hsa049780.43190771
138Renal cell carcinoma_Homo sapiens_hsa052110.43181194
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.41919575
140Estrogen signaling pathway_Homo sapiens_hsa049150.41880600
141Cyanoamino acid metabolism_Homo sapiens_hsa004600.41568426
142Gastric acid secretion_Homo sapiens_hsa049710.41236161
143Alzheimers disease_Homo sapiens_hsa050100.39961200
144Calcium signaling pathway_Homo sapiens_hsa040200.39883541
145MicroRNAs in cancer_Homo sapiens_hsa052060.38415547
146DNA replication_Homo sapiens_hsa030300.36334428
147Basal cell carcinoma_Homo sapiens_hsa052170.33605049
148cAMP signaling pathway_Homo sapiens_hsa040240.33282952
149HTLV-I infection_Homo sapiens_hsa051660.31770655
150Complement and coagulation cascades_Homo sapiens_hsa046100.31513116
151Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30831239
152Phospholipase D signaling pathway_Homo sapiens_hsa040720.30077737
153Systemic lupus erythematosus_Homo sapiens_hsa053220.29408011
154Thyroid hormone synthesis_Homo sapiens_hsa049180.29240653
155mTOR signaling pathway_Homo sapiens_hsa041500.28949522
156Arginine and proline metabolism_Homo sapiens_hsa003300.28620379
157Salivary secretion_Homo sapiens_hsa049700.27353834
158Mismatch repair_Homo sapiens_hsa034300.26454982

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