KANK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)6.58446486
2desmosome organization (GO:0002934)6.16792049
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.73764940
4regulation of transforming growth factor beta2 production (GO:0032909)4.94572995
5neurofilament cytoskeleton organization (GO:0060052)4.92837315
6diaphragm development (GO:0060539)4.69706034
7neuronal action potential propagation (GO:0019227)4.65610693
8cell-cell junction maintenance (GO:0045217)4.64587608
9skeletal muscle organ development (GO:0060538)4.37705866
10cell-substrate junction assembly (GO:0007044)4.23995149
11negative regulation of keratinocyte proliferation (GO:0010839)4.19600010
12glomerular basement membrane development (GO:0032836)4.15279018
13glomerular visceral epithelial cell development (GO:0072015)4.00970234
14cell migration in hindbrain (GO:0021535)3.99596211
15regulation of hair follicle development (GO:0051797)3.99583724
16paraxial mesoderm development (GO:0048339)3.93403634
17cell junction maintenance (GO:0034331)3.90250045
18generation of neurons (GO:0048699)3.85320115
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83405582
20regulation of translational termination (GO:0006449)3.72759189
21negative regulation of cartilage development (GO:0061037)3.66613054
22negative regulation of chondrocyte differentiation (GO:0032331)3.65593860
23establishment of monopolar cell polarity (GO:0061162)3.64925151
24establishment or maintenance of monopolar cell polarity (GO:0061339)3.64925151
25lung-associated mesenchyme development (GO:0060484)3.59899609
26polarized epithelial cell differentiation (GO:0030859)3.59213169
27hemidesmosome assembly (GO:0031581)3.57183722
28embryonic skeletal joint morphogenesis (GO:0060272)3.56232446
29plasma membrane repair (GO:0001778)3.55656232
30glomerular epithelial cell development (GO:0072310)3.55010227
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.53889578
32mesenchymal cell differentiation involved in kidney development (GO:0072161)3.53087710
33mesenchymal cell differentiation involved in renal system development (GO:2001012)3.53087710
34negative regulation of kidney development (GO:0090185)3.48124691
35positive regulation of male gonad development (GO:2000020)3.47430279
36endodermal cell differentiation (GO:0035987)3.45041019
37cytoskeletal anchoring at plasma membrane (GO:0007016)3.42953808
38positive regulation of odontogenesis (GO:0042482)3.36018639
39peripheral nervous system axon ensheathment (GO:0032292)3.35737671
40myelination in peripheral nervous system (GO:0022011)3.35737671
41establishment of apical/basal cell polarity (GO:0035089)3.30811045
42regulation of somitogenesis (GO:0014807)3.17105418
43hippo signaling (GO:0035329)3.15076224
44enteric nervous system development (GO:0048484)3.14403129
45proline transport (GO:0015824)3.13532666
46renal filtration (GO:0097205)3.13210137
47basement membrane organization (GO:0071711)3.13018000
48mesonephros development (GO:0001823)3.12969143
49regulation of keratinocyte proliferation (GO:0010837)3.10326283
50segment specification (GO:0007379)3.08217866
51negative regulation of metanephros development (GO:0072217)2.97615854
52mammary gland development (GO:0030879)2.97418563
53cell proliferation involved in metanephros development (GO:0072203)2.97101418
54non-canonical Wnt signaling pathway (GO:0035567)2.96930130
55nephron tubule formation (GO:0072079)2.95854135
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.94679664
57G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.93761209
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93202597
59regulation of glomerulus development (GO:0090192)2.90872566
60glomerular filtration (GO:0003094)2.90478040
61keratinocyte proliferation (GO:0043616)2.88851669
62embryonic camera-type eye development (GO:0031076)2.86107482
63layer formation in cerebral cortex (GO:0021819)2.85807726
64plasma lipoprotein particle assembly (GO:0034377)2.82923882
65low-density lipoprotein particle clearance (GO:0034383)2.80632186
66very-low-density lipoprotein particle assembly (GO:0034379)2.79632998
67anterior/posterior axis specification, embryo (GO:0008595)2.79355562
68regulation of establishment of planar polarity (GO:0090175)2.79158203
69embryonic forelimb morphogenesis (GO:0035115)2.78841371
70detection of temperature stimulus (GO:0016048)2.78420156
71plasma lipoprotein particle clearance (GO:0034381)2.77340592
72extracellular matrix disassembly (GO:0022617)2.76281625
73collagen catabolic process (GO:0030574)2.74907208
74intermediate filament organization (GO:0045109)2.74448286
75mesenchyme morphogenesis (GO:0072132)2.74440528
76vascular endothelial growth factor signaling pathway (GO:0038084)2.73890509
77dopamine biosynthetic process (GO:0042416)2.71537244
78regulation of cholesterol biosynthetic process (GO:0045540)2.70167926
79cell proliferation involved in kidney development (GO:0072111)2.70140045
80gap junction assembly (GO:0016264)2.69573907
81regulation of cholesterol esterification (GO:0010872)2.69503094
82regulation of Rac protein signal transduction (GO:0035020)2.69306106
83cellular component maintenance (GO:0043954)2.69227474
84positive regulation of hair cycle (GO:0042635)2.68440448
85positive regulation of hair follicle development (GO:0051798)2.68440448
86negative regulation of potassium ion transmembrane transport (GO:1901380)2.68206125
87mesenchymal cell proliferation (GO:0010463)2.67993893
88neuromuscular process controlling posture (GO:0050884)2.67231427
89ectodermal placode formation (GO:0060788)2.66458614
90muscle cell fate commitment (GO:0042693)2.66398306
91collagen metabolic process (GO:0032963)2.65965498
92labyrinthine layer development (GO:0060711)2.65156831
93negative regulation of microtubule polymerization (GO:0031115)2.64484700
94negative chemotaxis (GO:0050919)2.64443353
95cell adhesion mediated by integrin (GO:0033627)2.64026877
96synaptic vesicle maturation (GO:0016188)2.62174473
97midgut development (GO:0007494)2.61806276
98metanephric epithelium development (GO:0072207)2.61285808
99regulation of male gonad development (GO:2000018)2.61226043
100glomerulus development (GO:0032835)2.60656055
101hypotonic response (GO:0006971)2.60037923
102protein-lipid complex assembly (GO:0065005)2.59045638
103endocardial cushion development (GO:0003197)2.58885409
104forelimb morphogenesis (GO:0035136)2.58779407
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57944133
106multicellular organismal catabolic process (GO:0044243)2.57170331
107neural crest cell development (GO:0014032)2.55277194
108cell differentiation involved in metanephros development (GO:0072202)2.54968571
109positive regulation of mesonephros development (GO:0061213)2.54182347
110atrioventricular valve morphogenesis (GO:0003181)2.53406155
111face development (GO:0060324)2.52817865
112embryonic skeletal system morphogenesis (GO:0048704)2.52405795
113negative regulation of catenin import into nucleus (GO:0035414)2.51809812
114multicellular organismal macromolecule metabolic process (GO:0044259)2.51514336
115triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.50790711
116regulation of short-term neuronal synaptic plasticity (GO:0048172)2.50311649
117negative regulation of epidermis development (GO:0045683)2.50017848
118cell migration involved in sprouting angiogenesis (GO:0002042)2.49351956
119regulation of mesonephros development (GO:0061217)2.49145374
120regulation of hair cycle (GO:0042634)2.48652082
121hindlimb morphogenesis (GO:0035137)2.47854650
122peripheral nervous system neuron development (GO:0048935)2.47780671
123axon extension (GO:0048675)2.47593721
124innervation (GO:0060384)2.47454571
125myoblast migration (GO:0051451)2.47298098
126mesenchyme development (GO:0060485)2.46977036
127establishment of nucleus localization (GO:0040023)2.46974781
128high-density lipoprotein particle remodeling (GO:0034375)2.46809654
129genitalia morphogenesis (GO:0035112)2.46617710
130peptidyl-tyrosine autophosphorylation (GO:0038083)2.46411539
131regulation of axon extension involved in axon guidance (GO:0048841)2.46264385
132branching involved in ureteric bud morphogenesis (GO:0001658)2.46235751
133regulation of sodium ion transmembrane transporter activity (GO:2000649)2.43065679
134notochord development (GO:0030903)2.42347716
135epidermis development (GO:0008544)2.42288523
136multicellular organismal metabolic process (GO:0044236)2.42084646
137peripheral nervous system development (GO:0007422)2.38881564
138regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.38111580
139regulation of axon guidance (GO:1902667)2.37645275
140cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.33947088
141anatomical structure regression (GO:0060033)2.33001934
142regulation of SMAD protein import into nucleus (GO:0060390)2.32135099
143protein targeting to plasma membrane (GO:0072661)2.31253149
144establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.30999125
145regulation of mitotic spindle organization (GO:0060236)2.30098057
146anatomical structure maturation (GO:0071695)2.28542587
147negative regulation of sodium ion transport (GO:0010766)2.28163008
148glutamate secretion (GO:0014047)2.27656294
149sodium ion export (GO:0071436)2.26236492
150surfactant homeostasis (GO:0043129)2.26139238
151protein localization to endosome (GO:0036010)2.24759311
152negative regulation of axon extension involved in axon guidance (GO:0048843)2.23895164
153epithelial cell-cell adhesion (GO:0090136)2.23585571
154developmental cell growth (GO:0048588)2.22361762
155kidney mesenchyme development (GO:0072074)2.22164296
156positive regulation of axon extension (GO:0045773)2.21231417
157neuron projection extension (GO:1990138)2.21162175
158collagen fibril organization (GO:0030199)2.21026641
159positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19821968
160protein heterotrimerization (GO:0070208)2.19350959
161organ induction (GO:0001759)2.19078286
162camera-type eye morphogenesis (GO:0048593)2.18755882
163regulation of hippo signaling (GO:0035330)2.18541287
164axon extension involved in axon guidance (GO:0048846)2.17678725
165neuron projection extension involved in neuron projection guidance (GO:1902284)2.17678725
166lymph vessel development (GO:0001945)2.17559447
167negative regulation of dendrite morphogenesis (GO:0050774)2.17497176
168calcium-mediated signaling using intracellular calcium source (GO:0035584)2.17364102
169regulation of potassium ion transmembrane transporter activity (GO:1901016)2.17128644
170neuromuscular process controlling balance (GO:0050885)2.16770794
171regulation of catenin import into nucleus (GO:0035412)2.16663291
172regulation of glomerular filtration (GO:0003093)2.16532585
173proximal/distal pattern formation (GO:0009954)2.15675736
174negative regulation of axon guidance (GO:1902668)2.14641852
175mating behavior (GO:0007617)2.14327448
176skin development (GO:0043588)2.14141246
177regulation of early endosome to late endosome transport (GO:2000641)2.13335701
178intermediate filament cytoskeleton organization (GO:0045104)2.12871469
179regulation of cardioblast differentiation (GO:0051890)2.12863667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human4.18257303
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36242794
3NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.94472281
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.88034217
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.86703346
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.63472690
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.46201171
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41986483
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.35652857
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24827567
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24827567
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24827567
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.23585485
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16665028
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11315050
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10403382
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.09328999
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06334978
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06334978
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04057768
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.02163593
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98770876
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.94652813
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.83078292
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81961427
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.81081374
27AHR_22903824_ChIP-Seq_MCF-7_Human1.73917675
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.72938340
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72254041
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71177361
31SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71141231
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70897430
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70242080
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69771322
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.69400694
36NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.69086782
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66217712
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65434456
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59006105
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57989879
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.57554054
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57337163
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55485921
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54841650
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.53377718
46TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52932317
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52172674
48EZH2_22144423_ChIP-Seq_EOC_Human1.51744641
49* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51399332
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.49740235
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.49240696
52KDM2B_26808549_Chip-Seq_K562_Human1.49188670
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49148136
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45875189
55SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45875189
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45426268
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.44623825
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44513677
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41381637
60TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38940715
61TCF4_18268006_ChIP-ChIP_LS174T_Human1.38186716
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37312632
63STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.37007974
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35516530
65* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.33670624
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32125953
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.31512603
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.31148983
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30167828
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30041584
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26721846
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.25816624
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.24290233
74ZNF274_21170338_ChIP-Seq_K562_Hela1.24170557
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23652727
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23017841
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22824383
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.22768774
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22718968
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.21972843
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21118579
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19713903
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.19338964
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.18655151
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18517610
86SOX2_20726797_ChIP-Seq_SW620_Human1.18222936
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16564339
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16440750
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16058592
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16035965
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16018866
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15765294
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13164596
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.13060438
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12643501
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11450769
97* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11336732
98AR_21909140_ChIP-Seq_LNCAP_Human1.09816918
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08257891
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07737987
101CDX2_20551321_ChIP-Seq_CACO-2_Human1.07490015
102* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07284965
103* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07277678
104POU5F1_16518401_ChIP-PET_MESCs_Mouse1.07125014
105NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06687844
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.06444245
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06258103
108AR_21572438_ChIP-Seq_LNCaP_Human1.06170988
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.05446190
110CLOCK_20551151_ChIP-Seq_293T_Human1.05367414
111NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03416041
112* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01138887
113SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01126209
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00032490
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.99046438
116EZH2_27294783_Chip-Seq_ESCs_Mouse0.98539659
117TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98330262
118TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98057277
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96592315
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96524609
121NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96503976
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.96155151
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95926822
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95341327
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95244241
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94679753
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94411866
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94243784
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93730008
130TP53_18474530_ChIP-ChIP_U2OS_Human0.93684968
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.93243893
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92856648
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92375456
134NANOG_16518401_ChIP-PET_MESCs_Mouse0.92046093
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91701987
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91263226
137CJUN_26792858_Chip-Seq_BT549_Human0.91188882
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86687210
139RNF2_27304074_Chip-Seq_NSC_Mouse0.84065719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane5.14263694
2MP0000579_abnormal_nail_morphology4.58576741
3MP0005623_abnormal_meninges_morphology3.56340852
4MP0000566_synostosis3.39669354
5MP0004858_abnormal_nervous_system2.88504431
6MP0001968_abnormal_touch/_nociception2.40126174
7MP0000537_abnormal_urethra_morphology2.14832615
8MP0002098_abnormal_vibrissa_morphology2.13951817
9MP0000534_abnormal_ureter_morphology2.12481597
10MP0000751_myopathy2.09704400
11MP0005409_darkened_coat_color2.08717886
12MP0004264_abnormal_extraembryonic_tissu2.01151401
13MP0008438_abnormal_cutaneous_collagen1.98227580
14MP0003122_maternal_imprinting1.94787905
15MP0005257_abnormal_intraocular_pressure1.93924525
16MP0000467_abnormal_esophagus_morphology1.93840127
17MP0005503_abnormal_tendon_morphology1.89623671
18MP0004145_abnormal_muscle_electrophysio1.86692301
19MP0002060_abnormal_skin_morphology1.85884046
20MP0003123_paternal_imprinting1.83383942
21MP0009780_abnormal_chondrocyte_physiolo1.81606452
22MP0003705_abnormal_hypodermis_morpholog1.77358545
23MP0010234_abnormal_vibrissa_follicle1.76014433
24MP0004084_abnormal_cardiac_muscle1.75915326
25MP0002733_abnormal_thermal_nociception1.75291332
26MP0000747_muscle_weakness1.75124092
27MP0003136_yellow_coat_color1.74666843
28MP0005275_abnormal_skin_tensile1.70123597
29MP0003045_fibrosis1.68285786
30MP0003315_abnormal_perineum_morphology1.67044891
31MP0002734_abnormal_mechanical_nocicepti1.66760804
32MP0005023_abnormal_wound_healing1.66041076
33MP0005377_hearing/vestibular/ear_phenot1.59891891
34MP0003878_abnormal_ear_physiology1.59891891
35MP0004270_analgesia1.59239834
36MP0002735_abnormal_chemical_nociception1.53960216
37MP0003942_abnormal_urinary_system1.53802158
38MP0009053_abnormal_anal_canal1.51513381
39MP0004381_abnormal_hair_follicle1.49162085
40MP0005187_abnormal_penis_morphology1.47739456
41MP0002736_abnormal_nociception_after1.46377352
42MP0005171_absent_coat_pigmentation1.44671699
43MP0008789_abnormal_olfactory_epithelium1.41000164
44MP0010030_abnormal_orbit_morphology1.40388981
45MP0001177_atelectasis1.39870212
46MP0006276_abnormal_autonomic_nervous1.37112078
47MP0001299_abnormal_eye_distance/1.36369979
48MP0004019_abnormal_vitamin_homeostasis1.35925568
49MP0001346_abnormal_lacrimal_gland1.34843316
50MP0009046_muscle_twitch1.33765215
51MP0002108_abnormal_muscle_morphology1.33637266
52MP0002653_abnormal_ependyma_morphology1.32910929
53MP0002697_abnormal_eye_size1.29021021
54MP0002184_abnormal_innervation1.29008955
55MP0000462_abnormal_digestive_system1.26628365
56MP0003634_abnormal_glial_cell1.26311269
57MP0000733_abnormal_muscle_development1.25421836
58MP0000750_abnormal_muscle_regeneration1.25397659
59MP0000383_abnormal_hair_follicle1.25156642
60MP0002751_abnormal_autonomic_nervous1.24144116
61MP0004859_abnormal_synaptic_plasticity1.23805527
62MP0001849_ear_inflammation1.23334017
63MP0000377_abnormal_hair_follicle1.21515664
64MP0002938_white_spotting1.21088288
65MP0001216_abnormal_epidermal_layer1.20849266
66MP0003283_abnormal_digestive_organ1.20814874
67MP0002249_abnormal_larynx_morphology1.20605180
68MP0002796_impaired_skin_barrier1.19996711
69MP0003937_abnormal_limbs/digits/tail_de1.19842710
70MP0005670_abnormal_white_adipose1.19161027
71MP0000003_abnormal_adipose_tissue1.18715337
72MP0003385_abnormal_body_wall1.18706109
73MP0003941_abnormal_skin_development1.16941170
74MP0001958_emphysema1.16030513
75MP0004233_abnormal_muscle_weight1.15486659
76MP0002067_abnormal_sensory_capabilities1.13368262
77MP0001970_abnormal_pain_threshold1.12972615
78MP0002896_abnormal_bone_mineralization1.12908365
79MP0010329_abnormal_lipoprotein_level1.09289786
80MP0000955_abnormal_spinal_cord1.08808467
81MP0003121_genomic_imprinting1.07918433
82MP0002116_abnormal_craniofacial_bone1.07823208
83MP0008260_abnormal_autophagy1.06925585
84MP0005248_abnormal_Harderian_gland1.06434867
85MP0000678_abnormal_parathyroid_gland1.05690889
86MP0000762_abnormal_tongue_morphology1.04677420
87MP0003566_abnormal_cell_adhesion1.03720410
88MP0004885_abnormal_endolymph1.03118624
89MP0005375_adipose_tissue_phenotype1.03041208
90MP0002272_abnormal_nervous_system1.02700046
91MP0005666_abnormal_adipose_tissue1.01812579
92MP0010678_abnormal_skin_adnexa1.01329859
93MP0000432_abnormal_head_morphology1.00862427
94MP0003935_abnormal_craniofacial_develop1.00456664
95MP0002109_abnormal_limb_morphology1.00189737
96MP0001270_distended_abdomen1.00027284
97MP0000778_abnormal_nervous_system0.98667906
98MP0001661_extended_life_span0.98482938
99MP0009250_abnormal_appendicular_skeleto0.98355634
100MP0005367_renal/urinary_system_phenotyp0.98238047
101MP0000516_abnormal_urinary_system0.98238047
102MP0008932_abnormal_embryonic_tissue0.98141651
103MP0002111_abnormal_tail_morphology0.98020974
104MP0003635_abnormal_synaptic_transmissio0.97931692
105MP0000920_abnormal_myelination0.97830212
106MP0003632_abnormal_nervous_system0.95701467
107MP0003755_abnormal_palate_morphology0.95074174
108MP0001348_abnormal_lacrimal_gland0.93834814
109MP0002084_abnormal_developmental_patter0.93040981
110MP0010771_integument_phenotype0.92506140
111MP0003938_abnormal_ear_development0.92107837
112MP0005360_urolithiasis0.92106060
113MP0003279_aneurysm0.90132858
114MP0000049_abnormal_middle_ear0.90062967
115MP0001286_abnormal_eye_development0.89858564
116MP0004036_abnormal_muscle_relaxation0.89480929
117MP0002085_abnormal_embryonic_tissue0.88820827
118MP0005508_abnormal_skeleton_morphology0.88117821
119MP0005501_abnormal_skin_physiology0.87814817
120MP0003115_abnormal_respiratory_system0.87614991
121MP0002269_muscular_atrophy0.87546798
122MP0002233_abnormal_nose_morphology0.86716895
123MP0003453_abnormal_keratinocyte_physiol0.86211509
124MP0004811_abnormal_neuron_physiology0.86109321
125MP0001340_abnormal_eyelid_morphology0.86043072
126MP0000163_abnormal_cartilage_morphology0.85231727
127MP0005197_abnormal_uvea_morphology0.85148567
128MP0000428_abnormal_craniofacial_morphol0.85105865
129MP0000639_abnormal_adrenal_gland0.84644931
130MP0002114_abnormal_axial_skeleton0.84506871
131MP0002009_preneoplasia0.83955875
132MP0003119_abnormal_digestive_system0.82457692
133MP0003567_abnormal_fetal_cardiomyocyte0.80793681
134MP0000013_abnormal_adipose_tissue0.80736907
135MP0005193_abnormal_anterior_eye0.80647166
136MP0001879_abnormal_lymphatic_vessel0.79480011
137MP0002139_abnormal_hepatobiliary_system0.79346619
138MP0002127_abnormal_cardiovascular_syste0.79328198
139MP0003861_abnormal_nervous_system0.78970594
140MP0002925_abnormal_cardiovascular_devel0.78358284
141MP0010368_abnormal_lymphatic_system0.77984145
142MP0000749_muscle_degeneration0.76791247
143MP0002086_abnormal_extraembryonic_tissu0.74631403
144MP0002234_abnormal_pharynx_morphology0.74617988
145MP0006138_congestive_heart_failure0.74001800
146MP0002115_abnormal_skeleton_extremities0.73911795
147MP0005408_hypopigmentation0.73862740
148MP0002168_other_aberrant_phenotype0.73407112
149MP0003936_abnormal_reproductive_system0.73084370
150MP0009384_cardiac_valve_regurgitation0.72596102
151MP0009931_abnormal_skin_appearance0.72463964
152MP0002089_abnormal_postnatal_growth/wei0.72213503
153MP0002282_abnormal_trachea_morphology0.71195640
154MP0002932_abnormal_joint_morphology0.69149371
155MP0003828_pulmonary_edema0.68847303
156MP0002882_abnormal_neuron_morphology0.67669929

Predicted human phenotypes

RankGene SetZ-score
1Segmental peripheral demyelination/remyelination (HP:0003481)7.82279305
2Insidious onset (HP:0003587)6.69470792
3Termporal pattern (HP:0011008)6.69470792
4Action tremor (HP:0002345)5.49765826
5Fragile nails (HP:0001808)5.47442320
6Milia (HP:0001056)5.34563989
7Onycholysis (HP:0001806)4.94760497
8Impaired proprioception (HP:0010831)4.86478624
9Plantar hyperkeratosis (HP:0007556)4.35143736
10Right ventricular cardiomyopathy (HP:0011663)4.29946678
11Steppage gait (HP:0003376)3.96376411
12Abnormality of nail color (HP:0100643)3.90843200
13Hammertoe (HP:0001765)3.73719242
14Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.63200669
15Increased CSF protein (HP:0002922)3.62555577
16Onion bulb formation (HP:0003383)3.61270855
17Lip pit (HP:0100267)3.56464282
18Cervical subluxation (HP:0003308)3.46640132
19Foot dorsiflexor weakness (HP:0009027)3.42858907
20Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.40186646
21Peripheral hypomyelination (HP:0007182)3.33069060
22Delayed epiphyseal ossification (HP:0002663)3.28150365
23Postural tremor (HP:0002174)3.27250284
24Abnormality of the foot musculature (HP:0001436)3.17449184
25Thin bony cortex (HP:0002753)3.09894712
26Atrophic scars (HP:0001075)3.06074168
27Hypoplastic ischia (HP:0003175)2.93927577
28Decreased motor nerve conduction velocity (HP:0003431)2.90467893
29Upper limb muscle weakness (HP:0003484)2.88851492
30Natal tooth (HP:0000695)2.87654652
31Osteomalacia (HP:0002749)2.87344405
32Abnormality of the ischium (HP:0003174)2.79857867
33Advanced eruption of teeth (HP:0006288)2.77540225
34Abnormality of the vocal cords (HP:0008777)2.77400225
35Peripheral demyelination (HP:0011096)2.67609285
36Cerebral aneurysm (HP:0004944)2.65098359
37Ankle contracture (HP:0006466)2.59144936
38Palmoplantar hyperkeratosis (HP:0000972)2.56251580
39Popliteal pterygium (HP:0009756)2.54910292
40Abnormality of the calcaneus (HP:0008364)2.52725888
41Flat acetabular roof (HP:0003180)2.52474306
42Ankyloglossia (HP:0010296)2.50438564
43Asymmetry of the thorax (HP:0001555)2.49819503
44Shallow orbits (HP:0000586)2.48285331
45Ridged nail (HP:0001807)2.44841329
46Anomalous pulmonary venous return (HP:0010772)2.44785892
47Calcaneovalgus deformity (HP:0001848)2.42629249
48Palmar hyperkeratosis (HP:0010765)2.42407308
49Neonatal short-limb short stature (HP:0008921)2.41222396
50Premature rupture of membranes (HP:0001788)2.34049419
51Vitreoretinal degeneration (HP:0000655)2.33539952
52Hypoplasia of dental enamel (HP:0006297)2.33378084
53Pili torti (HP:0003777)2.31188193
54Enlarged epiphyses (HP:0010580)2.30243776
55Potter facies (HP:0002009)2.27386817
56Facial shape deformation (HP:0011334)2.27386817
57Hypophosphatemic rickets (HP:0004912)2.24666935
58Shawl scrotum (HP:0000049)2.24100862
59Proximal tubulopathy (HP:0000114)2.22778955
60Protrusio acetabuli (HP:0003179)2.22118749
61Limb dystonia (HP:0002451)2.20738322
62Nail dystrophy (HP:0008404)2.19550284
63Absent eyelashes (HP:0000561)2.18561930
64Thick nail (HP:0001805)2.18403960
65Broad metatarsal (HP:0001783)2.18043017
66Fragile skin (HP:0001030)2.16991868
67Abnormal pupillary function (HP:0007686)2.14189523
68Distal sensory impairment (HP:0002936)2.13359662
69Myokymia (HP:0002411)2.13194900
70Absent eyebrow (HP:0002223)2.12139216
71Myelomeningocele (HP:0002475)2.09624308
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.08597984
73Deformed tarsal bones (HP:0008119)2.05460637
74Arthropathy (HP:0003040)2.03294737
75Abnormality of the pulmonary veins (HP:0011718)2.02434110
76Morphological abnormality of the middle ear (HP:0008609)2.02339387
77Ulnar claw (HP:0001178)10.2442761
78Bladder diverticulum (HP:0000015)1.99554835
79Woolly hair (HP:0002224)1.97731996
80Abnormality of carpal bone ossification (HP:0006257)1.97686320
81Abnormality of the pubic bones (HP:0003172)1.97539318
82Sprengel anomaly (HP:0000912)1.92983012
83Infantile muscular hypotonia (HP:0008947)1.92572875
84Renal duplication (HP:0000075)1.90489919
85Epiphyseal dysplasia (HP:0002656)1.90227440
86Cupped ribs (HP:0000887)1.89885514
87Abnormality of the lower motor neuron (HP:0002366)1.88915627
88Progressive sensorineural hearing impairment (HP:0000408)1.88821826
89Wrist flexion contracture (HP:0001239)1.88149671
90Pheochromocytoma (HP:0002666)1.86095815
91Bowel diverticulosis (HP:0005222)1.85689032
92Anonychia (HP:0001798)1.85277208
93Abnormality of the nasal septum (HP:0000419)1.84776816
94Deep venous thrombosis (HP:0002625)1.84172941
95Abnormality of oral frenula (HP:0000190)1.81870602
96Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.81714995
97Vertebral hypoplasia (HP:0008417)1.81714995
98Arterial tortuosity (HP:0005116)1.80934126
99Cutaneous syndactyly (HP:0012725)1.79750109
100Fused cervical vertebrae (HP:0002949)1.79110082
101Annular pancreas (HP:0001734)1.78990312
102Bifid tongue (HP:0010297)1.78528995
103Abnormality of the lacrimal duct (HP:0011481)1.78119584
104Focal segmental glomerulosclerosis (HP:0000097)1.77461100
105Vertebral clefting (HP:0008428)1.77160233
106Hypomagnesemia (HP:0002917)1.76208209
107Overgrowth (HP:0001548)1.75876974
108Hypercholesterolemia (HP:0003124)1.74111015
109Hypoventilation (HP:0002791)1.73582234
110Abnormality of the labia minora (HP:0012880)1.73572672
111Metaphyseal cupping (HP:0003021)1.73067920
112Irregular epiphyses (HP:0010582)1.72943844
113Hypodontia (HP:0000668)1.72904650
114Abnormality of the astrocytes (HP:0100707)1.72043044
115Astrocytoma (HP:0009592)1.72043044
116Tibial bowing (HP:0002982)1.71855025
117Abnormality of calcium-phosphate metabolism (HP:0100530)1.71609141
118Broad palm (HP:0001169)1.71018768
119Abnormality of the nasolacrimal system (HP:0000614)1.70718737
120Concave nail (HP:0001598)1.70247396
121Esophageal atresia (HP:0002032)1.69332057
122Ependymoma (HP:0002888)1.69072549
123Hypoplastic left heart (HP:0004383)1.69058444
124Abnormal blistering of the skin (HP:0008066)1.68138323
125Atonic seizures (HP:0010819)1.67958894
126Hypotrichosis (HP:0001006)1.67575460
127Microglossia (HP:0000171)1.67161825
128Vascular tortuosity (HP:0004948)1.66841795
129Aortic dissection (HP:0002647)1.66601313
130Sparse scalp hair (HP:0002209)1.66449552
131Midline defect of the nose (HP:0004122)1.66410798
132Abnormal lung lobation (HP:0002101)1.66375698
133Wide anterior fontanel (HP:0000260)1.66292406
134Limited hip movement (HP:0008800)1.65520248
135Osteoarthritis (HP:0002758)1.65187741
136Alacrima (HP:0000522)1.64275183
137High anterior hairline (HP:0009890)1.63407198
138Renovascular hypertension (HP:0100817)1.61971517
139Lymphangioma (HP:0100764)1.61665253
140Short 4th metacarpal (HP:0010044)1.60981059
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60981059
142Chin dimple (HP:0010751)1.59824418
143Turricephaly (HP:0000262)1.58522037
144Muscle fiber splitting (HP:0003555)1.56928320
145Aplasia cutis congenita (HP:0001057)1.55514723
146Kyphoscoliosis (HP:0002751)1.55382693
147Bicornuate uterus (HP:0000813)1.54822534
148Mitral valve prolapse (HP:0001634)1.54328629
149Myotonia (HP:0002486)1.54103321
150Increased connective tissue (HP:0009025)1.52097029
151Venous insufficiency (HP:0005293)1.51660446
152Hypercortisolism (HP:0001578)1.49243112
153Difficulty climbing stairs (HP:0003551)1.47923740
154Neoplasm of the peripheral nervous system (HP:0100007)1.46535044
155Buphthalmos (HP:0000557)1.46501950
156Narrow nasal bridge (HP:0000446)1.46335080
157Metaphyseal dysplasia (HP:0100255)1.45726952
158Hyporeflexia of lower limbs (HP:0002600)1.45721006
159Abnormality of the 4th metacarpal (HP:0010012)1.45452154
160Coronal craniosynostosis (HP:0004440)1.45226623
161Genu recurvatum (HP:0002816)1.44985945
162Difficulty running (HP:0009046)1.43450147
163Hepatoblastoma (HP:0002884)1.42831144
164Cutaneous finger syndactyly (HP:0010554)1.41913277
165Knee flexion contracture (HP:0006380)1.38656236
166Soft skin (HP:0000977)1.37384730
167Pterygium (HP:0001059)1.37060184
168Abnormality of magnesium homeostasis (HP:0004921)1.37058254
169Camptodactyly of toe (HP:0001836)1.36769142
170Rapidly progressive (HP:0003678)1.36505274
171Mesangial abnormality (HP:0001966)1.35740168
172Enlarged penis (HP:0000040)1.35726082
173Abnormality of pain sensation (HP:0010832)1.34704495
174Impaired pain sensation (HP:0007328)1.34704495
175Failure to thrive in infancy (HP:0001531)1.34619309
176Alopecia of scalp (HP:0002293)1.34371888
177Glomerulosclerosis (HP:0000096)1.34035980
178Germ cell neoplasia (HP:0100728)1.33892847
179Focal seizures (HP:0007359)1.33864819
180Hip contracture (HP:0003273)1.33672323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.63364142
2WNK43.46304815
3STK393.28492509
4LMTK23.12618069
5MAP3K92.94187906
6FGFR42.69703192
7LATS12.57890892
8KSR22.32706502
9TIE12.05040763
10EPHB22.02452609
11AKT31.96089256
12MINK11.92574243
13NLK1.87900118
14FER1.87417718
15WNK11.82305015
16RET1.76343149
17NTRK11.73583444
18PIK3CA1.72332259
19MST1R1.67291790
20GRK51.66271227
21NTRK31.64153015
22MATK1.62448322
23MAP3K21.61745185
24PDGFRA1.56433082
25BRSK21.55066557
26EPHA21.54954802
27DDR21.48259232
28MAP3K41.43948898
29STK381.42911096
30STK38L1.41571157
31NEK11.38272262
32PNCK1.37830910
33SCYL21.33576851
34PKN21.33227417
35SIK11.32894749
36PAK41.29766300
37MKNK11.22228871
38PAK61.22203943
39MAP3K61.17177322
40LIMK11.16088059
41ICK1.13816294
42NEK91.13204813
43FGFR31.12513739
44CDK121.08380336
45TRPM71.06082410
46OXSR11.03612050
47PHKG11.02219933
48PHKG21.02219933
49NME10.99162629
50PLK40.98215731
51PTK20.96811888
52EPHA30.96149159
53MAPKAPK50.95184910
54ARAF0.94400678
55FLT30.92310635
56CSNK1G10.90196540
57MAP2K40.88581763
58PIM20.88422519
59CSNK1G20.88404639
60TYRO30.86874529
61CSNK1G30.86541919
62EEF2K0.84345339
63BMX0.81475115
64PTK2B0.78111090
65PRKD30.77586831
66BRD40.76885446
67CAMK1G0.75597234
68BRSK10.73423184
69ERBB30.72372691
70MAPKAPK30.71891927
71RPS6KL10.71028974
72RPS6KC10.71028974
73RIPK10.70656108
74KSR10.70593547
75MAP2K10.70440150
76PRKAA20.70354457
77CDK190.69429918
78TSSK60.69088330
79ADRBK10.68285814
80KDR0.67960785
81TGFBR20.66373438
82ERBB20.65795536
83FGFR20.64874594
84MTOR0.64531399
85ALK0.64083463
86PDK20.63947428
87TRIB30.63687616
88GSK3A0.61803722
89RAF10.61695433
90MAP3K120.60330684
91MARK20.59753678
92PLK30.59252876
93CDK140.58236352
94UHMK10.57757565
95ROCK10.57337425
96PRKD20.56941644
97CSNK1E0.56259566
98PDK30.56131914
99PDK40.56131914
100MAP2K20.55947883
101PLK20.55112337
102CAMK1D0.54964741
103RPS6KA60.53619674
104STK30.53039038
105ILK0.52768887
106TGFBR10.52641019
107CHEK20.51968662
108PDGFRB0.51652988
109BCR0.51372824
110PAK20.50802718
111BMPR1B0.49961381
112EPHB10.48500979
113MAP3K110.47957204
114PAK30.47410299
115AURKA0.46706794
116CDC42BPA0.46409859
117TTN0.46303372
118IRAK20.45913256
119PBK0.45904206
120PRKCI0.45761499
121CDK150.45501271
122CDK50.44596518
123CDK180.43493777
124MET0.42595572
125RPS6KB20.42323479
126MAPK100.41839107
127BUB10.41602750
128PRKAA10.41156313
129FGFR10.39914728
130BRAF0.39581150
131CLK10.39463303
132PTK60.38209861
133CDK60.37913651
134MKNK20.37528648
135CDK11A0.36967528
136FGR0.36626016
137CSNK1A1L0.35994390
138ROCK20.35803120
139CDK70.35013952
140RPS6KA20.33259855
141TTK0.32013643
142PRKCE0.31785077
143PIK3CG0.29838516
144CAMKK20.29201568
145STK240.28332375
146SRC0.27725618
147PRKACG0.26819088

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.85760487
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24721113
3Dorso-ventral axis formation_Homo sapiens_hsa043202.14400631
4Synaptic vesicle cycle_Homo sapiens_hsa047212.12745563
5Hedgehog signaling pathway_Homo sapiens_hsa043402.10263098
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.98933360
7PPAR signaling pathway_Homo sapiens_hsa033201.97158742
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96118416
9Hippo signaling pathway_Homo sapiens_hsa043901.89923593
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83997393
11Focal adhesion_Homo sapiens_hsa045101.82909470
12Tight junction_Homo sapiens_hsa045301.67664330
13Fat digestion and absorption_Homo sapiens_hsa049751.65839270
14Axon guidance_Homo sapiens_hsa043601.65163033
15Dilated cardiomyopathy_Homo sapiens_hsa054141.64152087
16Steroid biosynthesis_Homo sapiens_hsa001001.63622240
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62335640
18Adherens junction_Homo sapiens_hsa045201.60063942
19Protein digestion and absorption_Homo sapiens_hsa049741.59192872
20Vitamin digestion and absorption_Homo sapiens_hsa049771.57389051
21Thyroid cancer_Homo sapiens_hsa052161.56746131
22Oocyte meiosis_Homo sapiens_hsa041141.55964633
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47593184
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46965674
25Complement and coagulation cascades_Homo sapiens_hsa046101.46728445
26Gap junction_Homo sapiens_hsa045401.46014274
27Basal cell carcinoma_Homo sapiens_hsa052171.41763397
28Amoebiasis_Homo sapiens_hsa051461.39368951
29Small cell lung cancer_Homo sapiens_hsa052221.38848368
30Endometrial cancer_Homo sapiens_hsa052131.37158836
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32770825
32Bladder cancer_Homo sapiens_hsa052191.31403541
33Estrogen signaling pathway_Homo sapiens_hsa049151.30393236
34Melanogenesis_Homo sapiens_hsa049161.29715293
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28415886
36Dopaminergic synapse_Homo sapiens_hsa047281.24616247
37Proteoglycans in cancer_Homo sapiens_hsa052051.24301284
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23789980
39Fatty acid degradation_Homo sapiens_hsa000711.23047437
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22906780
41Other glycan degradation_Homo sapiens_hsa005111.21558475
42Glioma_Homo sapiens_hsa052141.21282926
43Long-term potentiation_Homo sapiens_hsa047201.21191457
44mTOR signaling pathway_Homo sapiens_hsa041501.21168509
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20146282
46Collecting duct acid secretion_Homo sapiens_hsa049661.20068992
47Melanoma_Homo sapiens_hsa052181.17766964
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17667779
49ErbB signaling pathway_Homo sapiens_hsa040121.17504582
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.17418535
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16863673
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.14803078
53Fatty acid elongation_Homo sapiens_hsa000621.14653468
54Taste transduction_Homo sapiens_hsa047421.13100847
55GnRH signaling pathway_Homo sapiens_hsa049121.10109044
56AMPK signaling pathway_Homo sapiens_hsa041521.09431904
57Salivary secretion_Homo sapiens_hsa049701.09233812
58Fatty acid metabolism_Homo sapiens_hsa012121.08445293
59Gastric acid secretion_Homo sapiens_hsa049711.07001282
60Galactose metabolism_Homo sapiens_hsa000521.06908941
61PI3K-Akt signaling pathway_Homo sapiens_hsa041511.06806243
62Rap1 signaling pathway_Homo sapiens_hsa040151.06620337
63Renal cell carcinoma_Homo sapiens_hsa052111.05169161
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04923364
65Wnt signaling pathway_Homo sapiens_hsa043101.04583910
66Glycerolipid metabolism_Homo sapiens_hsa005611.04418226
67TGF-beta signaling pathway_Homo sapiens_hsa043501.03740855
68Long-term depression_Homo sapiens_hsa047301.03686763
69Amphetamine addiction_Homo sapiens_hsa050311.03039954
70Lysine degradation_Homo sapiens_hsa003101.02421762
71Sulfur relay system_Homo sapiens_hsa041221.02353566
72Vitamin B6 metabolism_Homo sapiens_hsa007501.00634998
73Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00369583
74Pathways in cancer_Homo sapiens_hsa052000.98850668
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97138414
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96190626
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93834836
78VEGF signaling pathway_Homo sapiens_hsa043700.92113234
79Folate biosynthesis_Homo sapiens_hsa007900.92090645
80Cholinergic synapse_Homo sapiens_hsa047250.91658021
81MicroRNAs in cancer_Homo sapiens_hsa052060.88849842
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86252410
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86118895
84Colorectal cancer_Homo sapiens_hsa052100.86023502
85Renin secretion_Homo sapiens_hsa049240.85589616
86Cocaine addiction_Homo sapiens_hsa050300.85217681
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85028304
88Circadian entrainment_Homo sapiens_hsa047130.83952685
89Vibrio cholerae infection_Homo sapiens_hsa051100.83218773
90Glucagon signaling pathway_Homo sapiens_hsa049220.82805619
91Serotonergic synapse_Homo sapiens_hsa047260.82089142
92Oxytocin signaling pathway_Homo sapiens_hsa049210.82088168
93N-Glycan biosynthesis_Homo sapiens_hsa005100.81337543
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81140955
95Insulin secretion_Homo sapiens_hsa049110.80276675
96Thyroid hormone synthesis_Homo sapiens_hsa049180.79735723
97Insulin signaling pathway_Homo sapiens_hsa049100.79547609
98Endocytosis_Homo sapiens_hsa041440.79387373
99Prostate cancer_Homo sapiens_hsa052150.78261221
100Nicotine addiction_Homo sapiens_hsa050330.77913853
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76447849
102GABAergic synapse_Homo sapiens_hsa047270.75333401
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74878438
104Ras signaling pathway_Homo sapiens_hsa040140.74534404
105Viral myocarditis_Homo sapiens_hsa054160.74050504
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.73856668
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.73359173
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.73144474
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72748640
110Retinol metabolism_Homo sapiens_hsa008300.70661940
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69920985
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69280105
113Notch signaling pathway_Homo sapiens_hsa043300.68884531
114Sulfur metabolism_Homo sapiens_hsa009200.68115862
115Pancreatic cancer_Homo sapiens_hsa052120.67330176
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.66969139
117Prolactin signaling pathway_Homo sapiens_hsa049170.66746249
118Fatty acid biosynthesis_Homo sapiens_hsa000610.65958587
119Non-small cell lung cancer_Homo sapiens_hsa052230.65224503
120Cell cycle_Homo sapiens_hsa041100.65206672
121Ovarian steroidogenesis_Homo sapiens_hsa049130.64653624
122Glutamatergic synapse_Homo sapiens_hsa047240.63199750
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63011552
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62910160
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62414584
126Choline metabolism in cancer_Homo sapiens_hsa052310.61501625
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61409027
128Renin-angiotensin system_Homo sapiens_hsa046140.60762418
129Cardiac muscle contraction_Homo sapiens_hsa042600.60571702
130RNA transport_Homo sapiens_hsa030130.60208909
131Histidine metabolism_Homo sapiens_hsa003400.59830490
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59118878
133MAPK signaling pathway_Homo sapiens_hsa040100.58986117
134Chronic myeloid leukemia_Homo sapiens_hsa052200.58428975
135Calcium signaling pathway_Homo sapiens_hsa040200.57313857
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55547382
137p53 signaling pathway_Homo sapiens_hsa041150.55080658
138Arginine biosynthesis_Homo sapiens_hsa002200.53519694
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52234158
140Arginine and proline metabolism_Homo sapiens_hsa003300.50916042
141Phenylalanine metabolism_Homo sapiens_hsa003600.47495315
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.44953262
143Bile secretion_Homo sapiens_hsa049760.44695163
144Pancreatic secretion_Homo sapiens_hsa049720.43818246
145ABC transporters_Homo sapiens_hsa020100.43770791
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41719825

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