KANSL1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.44672392
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.03121913
3positive regulation of gamma-delta T cell activation (GO:0046645)4.99191656
4definitive hemopoiesis (GO:0060216)4.68041482
5positive regulation of B cell differentiation (GO:0045579)4.61227895
6cilium movement (GO:0003341)4.28515009
7neural tube formation (GO:0001841)4.11100027
8epithelial cilium movement (GO:0003351)4.01848345
9axoneme assembly (GO:0035082)3.92642935
10mitotic sister chromatid cohesion (GO:0007064)3.84056449
11positive regulation of granulocyte differentiation (GO:0030854)3.67776875
12establishment of protein localization to Golgi (GO:0072600)3.61715921
13protein K11-linked deubiquitination (GO:0035871)3.61133431
14histone H3-K4 trimethylation (GO:0080182)3.59731523
15protein localization to cilium (GO:0061512)3.56298175
16response to pheromone (GO:0019236)3.55906501
17regulation of gamma-delta T cell activation (GO:0046643)3.50694237
18regulation of gamma-delta T cell differentiation (GO:0045586)3.48881460
19regulation of B cell differentiation (GO:0045577)3.31783813
20monoubiquitinated protein deubiquitination (GO:0035520)3.28506744
21axonemal dynein complex assembly (GO:0070286)3.27721067
22genitalia morphogenesis (GO:0035112)3.23449423
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.21851245
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20342741
25intraciliary transport (GO:0042073)3.19905285
26positive regulation of histone deacetylation (GO:0031065)3.19876453
27photoreceptor cell maintenance (GO:0045494)3.17426895
28cilium organization (GO:0044782)3.16972760
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13993234
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13993234
31embryonic hemopoiesis (GO:0035162)3.11309746
32behavioral response to nicotine (GO:0035095)3.10598830
33cilium assembly (GO:0042384)3.08407270
34retinal cone cell development (GO:0046549)3.07437521
35lymphoid progenitor cell differentiation (GO:0002320)3.06624700
36presynaptic membrane assembly (GO:0097105)3.05678602
37V(D)J recombination (GO:0033151)3.05244001
38protein targeting to Golgi (GO:0000042)3.04522411
39regulation of cilium movement (GO:0003352)3.03661103
40positive regulation of natural killer cell differentiation (GO:0032825)3.03475365
41regulation of relaxation of muscle (GO:1901077)3.03063329
42negative regulation of sodium ion transport (GO:0010766)3.02292465
43cilium morphogenesis (GO:0060271)3.01195994
44T cell homeostasis (GO:0043029)3.01149292
45regulation of pigment cell differentiation (GO:0050932)2.97347482
46L-fucose catabolic process (GO:0042355)2.96214274
47fucose catabolic process (GO:0019317)2.96214274
48L-fucose metabolic process (GO:0042354)2.96214274
49negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95771978
50platelet dense granule organization (GO:0060155)2.93117992
51secretory granule organization (GO:0033363)2.93060371
52regulation of granulocyte differentiation (GO:0030852)2.90246500
53valine metabolic process (GO:0006573)2.89586799
54limb bud formation (GO:0060174)2.88871043
55positive regulation of developmental pigmentation (GO:0048087)2.88420308
56aminoglycoside antibiotic metabolic process (GO:0030647)2.88404134
57kidney morphogenesis (GO:0060993)2.87560866
58relaxation of cardiac muscle (GO:0055119)2.86378547
59B cell receptor signaling pathway (GO:0050853)2.84926120
60lymph node development (GO:0048535)2.84365853
61T cell differentiation in thymus (GO:0033077)2.84037807
62B cell homeostasis (GO:0001782)2.83742623
63lymph vessel development (GO:0001945)2.83610436
64nonmotile primary cilium assembly (GO:0035058)2.81224720
65indolalkylamine metabolic process (GO:0006586)2.80230907
66regulation of cell communication by electrical coupling (GO:0010649)2.78237503
67cytoplasmic mRNA processing body assembly (GO:0033962)2.77742265
68indole-containing compound catabolic process (GO:0042436)2.76419470
69indolalkylamine catabolic process (GO:0046218)2.76419470
70tryptophan catabolic process (GO:0006569)2.76419470
71regulation of DNA endoreduplication (GO:0032875)2.75819323
72embryonic camera-type eye morphogenesis (GO:0048596)2.75202050
73negative regulation of granulocyte differentiation (GO:0030853)2.74440491
74CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.73908157
75negative regulation of stress fiber assembly (GO:0051497)2.73275929
76cellular component assembly involved in morphogenesis (GO:0010927)2.72452064
77lymphocyte homeostasis (GO:0002260)2.72450177
78antigen processing and presentation of endogenous antigen (GO:0019883)2.71963325
79inner ear receptor stereocilium organization (GO:0060122)2.70348207
80regulation of action potential (GO:0098900)2.68744067
81B cell differentiation (GO:0030183)2.66833816
82regulation of natural killer cell differentiation (GO:0032823)2.66612266
83nucleus localization (GO:0051647)2.66024070
84presynaptic membrane organization (GO:0097090)2.65782939
85regulation of glucokinase activity (GO:0033131)2.65339089
86regulation of hexokinase activity (GO:1903299)2.65339089
87detection of light stimulus involved in visual perception (GO:0050908)2.64866401
88detection of light stimulus involved in sensory perception (GO:0050962)2.64866401
89reflex (GO:0060004)2.64712685
90pericardium development (GO:0060039)2.64662005
91germ cell migration (GO:0008354)2.63030593
92leukocyte homeostasis (GO:0001776)2.62447761
93negative regulation of neurotransmitter transport (GO:0051589)2.62381825
94regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62023174
95regulation of histone H3-K9 methylation (GO:0051570)2.60181807
96cellular hyperosmotic response (GO:0071474)2.59080793
97otic vesicle formation (GO:0030916)2.58947350
98drug transmembrane transport (GO:0006855)2.58748348
99regulation of sarcomere organization (GO:0060297)2.57755501
100peptidyl-lysine trimethylation (GO:0018023)2.57285345
101negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55757969
102negative regulation of translation, ncRNA-mediated (GO:0040033)2.55757969
103regulation of translation, ncRNA-mediated (GO:0045974)2.55757969
104regulation of hippo signaling (GO:0035330)2.55464131
105phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54898712
106positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54308815
107regulation of necroptotic process (GO:0060544)2.53956806
108tryptophan metabolic process (GO:0006568)2.50578415
109prostate gland growth (GO:0060736)2.50544492
110antigen processing and presentation via MHC class Ib (GO:0002475)2.48919845
111positive regulation of natural killer cell activation (GO:0032816)2.48836798
112prenylation (GO:0097354)2.48431757
113protein prenylation (GO:0018342)2.48431757
114ventricular system development (GO:0021591)2.48318405
115dopamine transport (GO:0015872)2.47109981
116cellular response to sterol (GO:0036315)2.46892672
117righting reflex (GO:0060013)2.46101103
118defense response to protozoan (GO:0042832)2.45854320
119positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45427058
120positive regulation of cardiac muscle hypertrophy (GO:0010613)2.44934047
121positive regulation of muscle hypertrophy (GO:0014742)2.44934047
122negative regulation of complement activation (GO:0045916)2.44856666
123tachykinin receptor signaling pathway (GO:0007217)2.44751209
124urate metabolic process (GO:0046415)2.44120683
125protein localization to Golgi apparatus (GO:0034067)2.44062388
126regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.43763300
127positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.43763300
128central nervous system neuron axonogenesis (GO:0021955)2.43225216
129dentate gyrus development (GO:0021542)2.42961836
130cellular response to zinc ion (GO:0071294)2.42753103
131polyol catabolic process (GO:0046174)2.42753061
132T-helper cell differentiation (GO:0042093)2.42738680
133CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.42738680
134serotonin metabolic process (GO:0042428)2.42098343
135proline transport (GO:0015824)2.41573801
136embryonic epithelial tube formation (GO:0001838)2.41386368
137response to protozoan (GO:0001562)2.40723440
138growth hormone receptor signaling pathway (GO:0060396)2.40084320
139cellular response to ethanol (GO:0071361)2.40060967
140response to interferon-alpha (GO:0035455)2.39810499
141behavioral response to ethanol (GO:0048149)2.39305463
142neuronal action potential (GO:0019228)2.38667944
143phospholipid scrambling (GO:0017121)2.38549825
144spinal cord motor neuron differentiation (GO:0021522)2.38542095
145indole-containing compound metabolic process (GO:0042430)2.38342977
146cilium or flagellum-dependent cell motility (GO:0001539)2.37373934
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37201121
148lactate metabolic process (GO:0006089)2.36834033
149microtubule anchoring (GO:0034453)2.36529939
150positive regulation of protein deacetylation (GO:0090312)2.35197488
151hindbrain development (GO:0030902)2.35141003
152cellular response to exogenous dsRNA (GO:0071360)2.34691698
153organic cation transport (GO:0015695)2.34419535
154motile cilium assembly (GO:0044458)2.34380489
155regulation of mRNA catabolic process (GO:0061013)2.33998847
156negative regulation of T cell apoptotic process (GO:0070233)2.33649060
157toxin transport (GO:1901998)2.33621361
158histone H3-K36 demethylation (GO:0070544)2.33004944
159CD4-positive, alpha-beta T cell activation (GO:0035710)2.32973605
160renal tubule morphogenesis (GO:0061333)2.32731772
161exocrine pancreas development (GO:0031017)2.31814304
162positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.31792294
163rRNA catabolic process (GO:0016075)2.31725063
164regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.31620365
165brain morphogenesis (GO:0048854)2.30373343
166histamine transport (GO:0051608)2.30352374
167appendage development (GO:0048736)2.29649938
168limb development (GO:0060173)2.29649938
169positive regulation of mRNA catabolic process (GO:0061014)2.29253120
170inositol phosphate catabolic process (GO:0071545)2.28396080
171left/right axis specification (GO:0070986)2.28226780
172regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.27548191
173primary amino compound metabolic process (GO:1901160)2.27061139
174necroptotic process (GO:0070266)2.26805505
175interkinetic nuclear migration (GO:0022027)2.26668652
176regulation of interferon-beta biosynthetic process (GO:0045357)2.26342732
177germinal center formation (GO:0002467)2.26341381
178retinal rod cell development (GO:0046548)2.25170677
179regulation of natural killer cell activation (GO:0032814)2.23956120
180regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.23908847
181T cell differentiation (GO:0030217)2.23759216
182detection of other organism (GO:0098543)2.23694155
183retrograde transport, vesicle recycling within Golgi (GO:0000301)2.23677213
184lymphocyte differentiation (GO:0030098)2.20777344
185positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.20677045
186acrosome assembly (GO:0001675)2.20170834
187negative regulation of B cell proliferation (GO:0030889)2.19528577
188embryonic viscerocranium morphogenesis (GO:0048703)2.19328151
189nuclear pore complex assembly (GO:0051292)2.19193074
190insulin-like growth factor receptor signaling pathway (GO:0048009)2.19047910
191positive regulation of interleukin-1 beta secretion (GO:0050718)2.17437603
192mast cell activation (GO:0045576)2.16904313
193positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.16789060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.42758412
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36280235
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.92294435
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.44482151
5GBX2_23144817_ChIP-Seq_PC3_Human3.27728403
6SCL_19346495_ChIP-Seq_HPC-7_Human2.96712485
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78530967
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74509949
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74353026
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57894810
11VDR_22108803_ChIP-Seq_LS180_Human2.56430276
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35143203
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31480173
14ZNF274_21170338_ChIP-Seq_K562_Hela2.26296712
15RUNX_20019798_ChIP-Seq_JUKART_Human2.25280887
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.22215775
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.18828294
18P300_19829295_ChIP-Seq_ESCs_Human2.13206460
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01857452
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.97503427
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95186416
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95032755
23SMAD4_21799915_ChIP-Seq_A2780_Human1.93942909
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87955749
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82975633
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78915565
27STAT3_23295773_ChIP-Seq_U87_Human1.78245824
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.75594526
29ER_23166858_ChIP-Seq_MCF-7_Human1.75502622
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70968753
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67448200
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66782808
33SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66229989
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.65431505
35UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65377207
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65097663
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65097663
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.64219465
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.63264605
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62512444
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62359642
42* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59297752
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58822106
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58472723
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.58339428
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.56690267
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55485206
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54810068
49AR_25329375_ChIP-Seq_VCAP_Human1.53413862
50CBP_20019798_ChIP-Seq_JUKART_Human1.52655724
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52655724
52FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49952468
53MYB_26560356_Chip-Seq_TH2_Human1.47866444
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47506844
55AR_21572438_ChIP-Seq_LNCaP_Human1.45770490
56VDR_24787735_ChIP-Seq_THP-1_Human1.45165850
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43066963
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41521872
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.39334294
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.38725267
61IGF1R_20145208_ChIP-Seq_DFB_Human1.37254602
62BCAT_22108803_ChIP-Seq_LS180_Human1.37170357
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36999370
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36798239
65MYB_26560356_Chip-Seq_TH1_Human1.34984714
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33965379
67TCF4_22108803_ChIP-Seq_LS180_Human1.31926790
68RUNX2_22187159_ChIP-Seq_PCA_Human1.31479123
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30736553
70TP53_16413492_ChIP-PET_HCT116_Human1.29023215
71* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28931421
72AHR_22903824_ChIP-Seq_MCF-7_Human1.28795082
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28183427
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27288149
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.25654446
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.24430998
77CDX2_22108803_ChIP-Seq_LS180_Human1.24284347
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24025077
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23619743
80NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23619743
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23483284
82FUS_26573619_Chip-Seq_HEK293_Human1.22770270
83EWS_26573619_Chip-Seq_HEK293_Human1.21569264
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20668978
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20282241
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.19945131
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.19690101
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19664500
89TAF15_26573619_Chip-Seq_HEK293_Human1.18440616
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18061173
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16654063
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.16203266
93PU_27001747_Chip-Seq_BMDM_Mouse1.14925868
94NANOG_19829295_ChIP-Seq_ESCs_Human1.14902861
95SOX2_19829295_ChIP-Seq_ESCs_Human1.14902861
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14534910
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.14375565
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.13794859
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13760775
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13586715
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13212055
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13010408
103P300_18555785_Chip-Seq_ESCs_Mouse1.12956359
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11858605
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11392907
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.11312687
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10484120
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.10236447
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09893358
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09392274
111BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09298098
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09020019
113STAT3_18555785_Chip-Seq_ESCs_Mouse1.08866748
114KDM2B_26808549_Chip-Seq_REH_Human1.08559245
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08549492
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.08042515
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07597762
118TP53_18474530_ChIP-ChIP_U2OS_Human1.07556685
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07487521
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07346517
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.06420153
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05910406
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05487719
124EZH2_22144423_ChIP-Seq_EOC_Human1.04052146
125ESR1_21235772_ChIP-Seq_MCF-7_Human1.04030328
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03872549
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03701788
128FOXO3_23340844_ChIP-Seq_DLD1_Human1.02929052
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02774081
130CJUN_26792858_Chip-Seq_BT549_Human1.02311708
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.02075791
132CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01886830
133GATA3_27048872_Chip-Seq_THYMUS_Human1.00374465
134EP300_21415370_ChIP-Seq_HL-1_Mouse1.00164623
135TCF7_22412390_ChIP-Seq_EML_Mouse1.00002394
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99683472
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98860549
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97747458
139EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96573396
140P53_22387025_ChIP-Seq_ESCs_Mouse0.96402235
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96209943
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.96189694
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95001660
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.94386459
145OCT4_18555785_Chip-Seq_ESCs_Mouse0.93706856
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93489510
147E2F7_22180533_ChIP-Seq_HELA_Human0.92721968
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92401558
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.92332225
150TCF4_23295773_ChIP-Seq_U87_Human0.91723627
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91346404
152VDR_24763502_ChIP-Seq_THP-1_Human0.90870903
153PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90398461
154TCF4_18268006_ChIP-ChIP_LS174T_Human0.90396319
155TP63_23658742_ChIP-Seq_EP156T_Human0.90079234
156SPI1_23547873_ChIP-Seq_NB4_Human0.89990616
157LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89557362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.83360491
2MP0002166_altered_tumor_susceptibility3.36538978
3MP0002396_abnormal_hematopoietic_system3.11781819
4MP0002138_abnormal_hepatobiliary_system3.01717425
5MP0002102_abnormal_ear_morphology2.78128060
6MP0001835_abnormal_antigen_presentation2.74499378
7MP0002006_tumorigenesis2.64803275
8MP0003300_gastrointestinal_ulcer2.64332542
9MP0000569_abnormal_digit_pigmentation2.49070497
10MP0002009_preneoplasia2.48787637
11MP0004808_abnormal_hematopoietic_stem2.43556692
12MP0005253_abnormal_eye_physiology2.40201077
13MP0001984_abnormal_olfaction2.29264808
14MP0000685_abnormal_immune_system2.28959365
15MP0001545_abnormal_hematopoietic_system2.27119701
16MP0005397_hematopoietic_system_phenotyp2.27119701
17MP0006072_abnormal_retinal_apoptosis2.21097160
18MP0004043_abnormal_pH_regulation2.19991073
19MP0009785_altered_susceptibility_to2.16682859
20MP0001879_abnormal_lymphatic_vessel2.16442119
21MP0005409_darkened_coat_color2.14364549
22MP0005551_abnormal_eye_electrophysiolog2.10872135
23MP0000372_irregular_coat_pigmentation2.01078751
24MP0003045_fibrosis1.99504797
25MP0009278_abnormal_bone_marrow1.93543770
26MP0001800_abnormal_humoral_immune1.90392362
27MP0000383_abnormal_hair_follicle1.87931277
28MP0002928_abnormal_bile_duct1.84127798
29MP0003880_abnormal_central_pattern1.83491110
30MP0010386_abnormal_urinary_bladder1.81028128
31MP0001486_abnormal_startle_reflex1.73512047
32MP0005671_abnormal_response_to1.72531308
33MP0009046_muscle_twitch1.70971716
34MP0002638_abnormal_pupillary_reflex1.70140468
35MP0001986_abnormal_taste_sensitivity1.66489354
36MP0003724_increased_susceptibility_to1.65183060
37MP0001501_abnormal_sleep_pattern1.64894163
38MP0003646_muscle_fatigue1.64469659
39MP0006054_spinal_hemorrhage1.61878815
40MP0002452_abnormal_antigen_presenting1.58396999
41MP0003252_abnormal_bile_duct1.56670255
42MP0000516_abnormal_urinary_system1.55902919
43MP0005367_renal/urinary_system_phenotyp1.55902919
44MP0004484_altered_response_of1.53793326
45MP0004215_abnormal_myocardial_fiber1.53112641
46MP0005387_immune_system_phenotype1.51987746
47MP0001790_abnormal_immune_system1.51987746
48MP0010155_abnormal_intestine_physiology1.51638873
49MP0002398_abnormal_bone_marrow1.51268457
50MP0002723_abnormal_immune_serum1.48970117
51MP0002095_abnormal_skin_pigmentation1.48017861
52MP0004145_abnormal_muscle_electrophysio1.47269431
53MP0002837_dystrophic_cardiac_calcinosis1.45398835
54MP0005000_abnormal_immune_tolerance1.45080930
55MP0010678_abnormal_skin_adnexa1.44641158
56MP0005174_abnormal_tail_pigmentation1.43706828
57MP0005025_abnormal_response_to1.42436896
58MP0002148_abnormal_hypersensitivity_rea1.41674572
59MP0002420_abnormal_adaptive_immunity1.41268930
60MP0001853_heart_inflammation1.41085523
61MP0002419_abnormal_innate_immunity1.38647773
62MP0001873_stomach_inflammation1.37448117
63MP0001819_abnormal_immune_cell1.37351736
64MP0003136_yellow_coat_color1.37010214
65MP0005248_abnormal_Harderian_gland1.36904860
66MP0005187_abnormal_penis_morphology1.36306580
67MP0003763_abnormal_thymus_physiology1.36163829
68MP0003828_pulmonary_edema1.33527300
69MP0000703_abnormal_thymus_morphology1.32213681
70MP0002876_abnormal_thyroid_physiology1.31322300
71MP0009745_abnormal_behavioral_response1.31022381
72MP0005666_abnormal_adipose_tissue1.29664749
73MP0003787_abnormal_imprinting1.29615913
74MP0005386_behavior/neurological_phenoty1.28446019
75MP0004924_abnormal_behavior1.28446019
76MP0000631_abnormal_neuroendocrine_gland1.27513654
77MP0002938_white_spotting1.27499278
78MP0005379_endocrine/exocrine_gland_phen1.27389822
79MP0003436_decreased_susceptibility_to1.25437317
80MP0000716_abnormal_immune_system1.25423590
81MP0002060_abnormal_skin_morphology1.25126754
82MP0001968_abnormal_touch/_nociception1.23647995
83MP0000689_abnormal_spleen_morphology1.23437474
84MP0003890_abnormal_embryonic-extraembry1.23274693
85MP0001485_abnormal_pinna_reflex1.22578660
86MP0002163_abnormal_gland_morphology1.21426632
87MP0005646_abnormal_pituitary_gland1.18779426
88MP0003183_abnormal_peptide_metabolism1.17502196
89MP0002722_abnormal_immune_system1.16600433
90MP0005365_abnormal_bile_salt1.14802084
91MP0001765_abnormal_ion_homeostasis1.14760050
92MP0008995_early_reproductive_senescence1.12794660
93MP0004947_skin_inflammation1.12693458
94MP0005645_abnormal_hypothalamus_physiol1.11781894
95MP0002254_reproductive_system_inflammat1.10944222
96MP0003950_abnormal_plasma_membrane1.10486833
97MP0010234_abnormal_vibrissa_follicle1.09932259
98MP0008877_abnormal_DNA_methylation1.08637821
99MP0002272_abnormal_nervous_system1.08524320
100MP0005464_abnormal_platelet_physiology1.07892420
101MP0001958_emphysema1.07449202
102MP0003868_abnormal_feces_composition1.07411832
103MP0008872_abnormal_physiological_respon1.06760753
104MP0010368_abnormal_lymphatic_system1.06583518
105MP0004084_abnormal_cardiac_muscle1.04918952
106MP0003191_abnormal_cellular_cholesterol1.04237035
107MP0003937_abnormal_limbs/digits/tail_de1.03625103
108MP0004130_abnormal_muscle_cell1.03224899
109MP0005220_abnormal_exocrine_pancreas1.01704109
110MP0005410_abnormal_fertilization1.01220531
111MP0009697_abnormal_copulation1.01189538
112MP0008007_abnormal_cellular_replicative1.00988768
113MP0002136_abnormal_kidney_physiology1.00907788
114MP0005670_abnormal_white_adipose1.00888160
115MP0001845_abnormal_inflammatory_respons0.99878742
116MP0004142_abnormal_muscle_tone0.99817926
117MP0005391_vision/eye_phenotype0.98220308
118MP0003943_abnormal_hepatobiliary_system0.98008196
119MP0009764_decreased_sensitivity_to0.97670407
120MP0000778_abnormal_nervous_system0.97098923
121MP0004147_increased_porphyrin_level0.96841532
122MP0002429_abnormal_blood_cell0.96435309
123MP0005195_abnormal_posterior_eye0.95877313
124MP0000465_gastrointestinal_hemorrhage0.95720083
125MP0005167_abnormal_blood-brain_barrier0.94989768
126MP0002909_abnormal_adrenal_gland0.94615838
127MP0002067_abnormal_sensory_capabilities0.94262454
128MP0004885_abnormal_endolymph0.93783435
129MP0009384_cardiac_valve_regurgitation0.93582358
130MP0000427_abnormal_hair_cycle0.93365643
131MP0002405_respiratory_system_inflammati0.92669697
132MP0008875_abnormal_xenobiotic_pharmacok0.90673538
133MP0003633_abnormal_nervous_system0.90671289
134MP0005075_abnormal_melanosome_morpholog0.89929508
135MP0004085_abnormal_heartbeat0.89059363
136MP0002064_seizures0.89009110
137MP0002572_abnormal_emotion/affect_behav0.87905391
138MP0008961_abnormal_basal_metabolism0.87757131
139MP0001324_abnormal_eye_pigmentation0.87685726
140MP0008469_abnormal_protein_level0.86789216
141MP0002108_abnormal_muscle_morphology0.85444805
142MP0005503_abnormal_tendon_morphology0.85440277
143MP0005423_abnormal_somatic_nervous0.85023994
144MP0004133_heterotaxia0.84442825
145MP0002139_abnormal_hepatobiliary_system0.84282241
146MP0009780_abnormal_chondrocyte_physiolo0.84253479
147MP0002168_other_aberrant_phenotype0.83321713
148MP0004019_abnormal_vitamin_homeostasis0.82861928
149MP0001191_abnormal_skin_condition0.82088847
150MP0003121_genomic_imprinting0.81507621
151MP0009765_abnormal_xenobiotic_induced0.81261593
152MP0002557_abnormal_social/conspecific_i0.80537157
153MP0009643_abnormal_urine_homeostasis0.80265859
154MP0005395_other_phenotype0.80105840
155MP0002933_joint_inflammation0.79183168
156MP0002233_abnormal_nose_morphology0.78339890
157MP0006276_abnormal_autonomic_nervous0.78010428
158MP0002735_abnormal_chemical_nociception0.78007313
159MP0002098_abnormal_vibrissa_morphology0.77475410
160MP0000377_abnormal_hair_follicle0.77019708
161MP0008057_abnormal_DNA_replication0.76870492
162MP0010094_abnormal_chromosome_stability0.75899823
163MP0002653_abnormal_ependyma_morphology0.74725963
164MP0005084_abnormal_gallbladder_morpholo0.74605114
165MP0000490_abnormal_crypts_of0.73017577
166MP0003635_abnormal_synaptic_transmissio0.71912131
167MP0004036_abnormal_muscle_relaxation0.71773235
168MP0000015_abnormal_ear_pigmentation0.71581487
169MP0002998_abnormal_bone_remodeling0.70761527
170MP0002063_abnormal_learning/memory/cond0.70240861
171MP0009115_abnormal_fat_cell0.70230785
172MP0000230_abnormal_systemic_arterial0.70096149
173MP0003137_abnormal_impulse_conducting0.69883449
174MP0003698_abnormal_male_reproductive0.69692695
175MP0010352_gastrointestinal_tract_polyps0.68622690
176MP0005647_abnormal_sex_gland0.67711150
177MP0002160_abnormal_reproductive_system0.67708024
178MP0005375_adipose_tissue_phenotype0.67626513
179MP0002736_abnormal_nociception_after0.67238787
180MP0002229_neurodegeneration0.66353618

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.35847910
2Thyroiditis (HP:0100646)4.29246447
3Hypoplasia of the thymus (HP:0000778)4.13999314
4Pancreatic cysts (HP:0001737)4.13769943
5Agammaglobulinemia (HP:0004432)4.01862960
6True hermaphroditism (HP:0010459)3.80459432
7Abnormality of B cell number (HP:0010975)3.73235432
8B lymphocytopenia (HP:0010976)3.73235432
9Pancreatic fibrosis (HP:0100732)3.70773654
10Hyperventilation (HP:0002883)3.68940104
11Abnormal ciliary motility (HP:0012262)3.44436246
12Panhypogammaglobulinemia (HP:0003139)3.43611159
13Abnormality of midbrain morphology (HP:0002418)3.39748906
14Molar tooth sign on MRI (HP:0002419)3.39748906
15Nephronophthisis (HP:0000090)3.34077404
16Recurrent viral infections (HP:0004429)3.16534643
17Hypoproteinemia (HP:0003075)3.11437871
18Acute myeloid leukemia (HP:0004808)3.05078064
19Abnormal respiratory epithelium morphology (HP:0012253)3.02722652
20Abnormal respiratory motile cilium morphology (HP:0005938)3.02722652
21Gaze-evoked nystagmus (HP:0000640)3.01040975
22Abnormal respiratory motile cilium physiology (HP:0012261)3.00949885
23Cystic liver disease (HP:0006706)2.97311380
24Chronic diarrhea (HP:0002028)2.84811367
25Abnormality of the renal cortex (HP:0011035)2.84277780
26Medial flaring of the eyebrow (HP:0010747)2.80036432
27Fair hair (HP:0002286)2.74969073
28Genetic anticipation (HP:0003743)2.69432035
29Rhinitis (HP:0012384)2.67404760
30Abnormality of the ischium (HP:0003174)2.64090282
31Hematochezia (HP:0002573)2.61309581
32Volvulus (HP:0002580)2.60378819
33Cellulitis (HP:0100658)2.59984629
34Febrile seizures (HP:0002373)2.58820009
35Severe combined immunodeficiency (HP:0004430)2.56405574
36Recurrent bronchitis (HP:0002837)2.55258631
37T lymphocytopenia (HP:0005403)2.54335135
38Colitis (HP:0002583)2.46865598
39Lip pit (HP:0100267)2.43136243
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.41534880
41Broad-based gait (HP:0002136)2.40925428
42Absent speech (HP:0001344)2.40282088
43IgM deficiency (HP:0002850)2.38510327
44Hypoplastic ischia (HP:0003175)2.34582685
45Gait imbalance (HP:0002141)2.33746536
46Stomach cancer (HP:0012126)2.32797648
47Congenital hepatic fibrosis (HP:0002612)2.30896037
48Truncal obesity (HP:0001956)2.30200548
49Progressive cerebellar ataxia (HP:0002073)2.29628409
50Postaxial foot polydactyly (HP:0001830)2.29112289
51Protruding tongue (HP:0010808)2.28830068
52Congenital primary aphakia (HP:0007707)2.28152102
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.27896212
54Abnormality of T cell number (HP:0011839)2.27800671
55Polydipsia (HP:0001959)2.27543931
56Abnormal drinking behavior (HP:0030082)2.27543931
57Abnormality of the nasal septum (HP:0000419)2.27473501
58Inflammation of the large intestine (HP:0002037)2.27218431
59Hypothermia (HP:0002045)2.25237571
60Osteomyelitis (HP:0002754)2.25069985
61Genital tract atresia (HP:0001827)2.24885839
62Decreased circulating renin level (HP:0003351)2.24278212
63Absent/shortened dynein arms (HP:0200106)2.24060287
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.24060287
65Periodontitis (HP:0000704)2.21163236
66Long eyelashes (HP:0000527)2.20012334
67Attenuation of retinal blood vessels (HP:0007843)2.18390309
68Polyuria (HP:0000103)2.18220800
69Generalized hypopigmentation of hair (HP:0011358)2.15813501
70Congenital stationary night blindness (HP:0007642)2.15696370
71Chronic otitis media (HP:0000389)2.15497620
72Myositis (HP:0100614)2.15046567
73Narrow palate (HP:0000189)2.14155463
74Abolished electroretinogram (ERG) (HP:0000550)2.14134031
75Vaginal atresia (HP:0000148)2.13857356
76Furrowed tongue (HP:0000221)2.13146573
77Bony spicule pigmentary retinopathy (HP:0007737)2.12950657
78Hyperkalemia (HP:0002153)2.10241625
79Macroorchidism (HP:0000053)2.09683851
80Meningitis (HP:0001287)2.09310859
81Recurrent fungal infections (HP:0002841)2.08724312
82Papillary thyroid carcinoma (HP:0002895)2.08470540
83Abnormality of renal excretion (HP:0011036)2.07430429
84Gastrointestinal inflammation (HP:0004386)2.05544781
85Abnormality of the renal medulla (HP:0100957)2.04943251
86Recurrent bacterial skin infections (HP:0005406)2.04844157
87Nephrogenic diabetes insipidus (HP:0009806)2.03513771
88Spondylolisthesis (HP:0003302)2.03252766
89Tubulointerstitial fibrosis (HP:0005576)2.03133319
90Hyperactive renin-angiotensin system (HP:0000841)2.02504559
91Cupped ear (HP:0000378)2.02466902
92Acute lymphatic leukemia (HP:0006721)2.02205943
93Abnormal urine output (HP:0012590)2.00835717
94Metaphyseal dysplasia (HP:0100255)1.98864524
95Interstitial pulmonary disease (HP:0006530)1.98764740
96Thin bony cortex (HP:0002753)1.98753529
97Spinal cord lesions (HP:0100561)1.98653089
98Syringomyelia (HP:0003396)1.98653089
99Drooling (HP:0002307)1.98565334
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98561275
101Recurrent sinusitis (HP:0011108)1.98402482
102Increased circulating renin level (HP:0000848)1.98188207
103Chronic hepatic failure (HP:0100626)1.97420160
104Intestinal atresia (HP:0011100)1.97211546
105Anencephaly (HP:0002323)1.96515040
106Alveolar cell carcinoma (HP:0006519)1.96060732
107Eosinophilia (HP:0001880)1.95404447
108Tubulointerstitial nephritis (HP:0001970)1.94723757
109Weak cry (HP:0001612)1.94315138
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94192760
111Occipital encephalocele (HP:0002085)1.93616392
112Abnormal rod and cone electroretinograms (HP:0008323)1.91968190
113Type II lissencephaly (HP:0007260)1.90278445
114Chorioretinal atrophy (HP:0000533)1.89727613
115Pigmentary retinal degeneration (HP:0001146)1.89580270
116Verrucae (HP:0200043)1.89217046
117Papilloma (HP:0012740)1.89217046
118Viral hepatitis (HP:0006562)1.88738941
119Postaxial hand polydactyly (HP:0001162)1.87837212
120Aqueductal stenosis (HP:0002410)1.87229758
121Abnormality of the labia majora (HP:0012881)1.87128879
122Absent frontal sinuses (HP:0002688)1.86080832
123Bile duct proliferation (HP:0001408)1.85552855
124Abnormal biliary tract physiology (HP:0012439)1.85552855
125Abnormality of the right ventricle (HP:0001707)1.82195735
126Neoplasm of the adrenal cortex (HP:0100641)1.82074920
127Male pseudohermaphroditism (HP:0000037)1.82023399
128Subacute progressive viral hepatitis (HP:0006572)1.81467174
129Bronchitis (HP:0012387)1.81263358
130Depressed nasal tip (HP:0000437)1.81032467
131Poor coordination (HP:0002370)1.78308224
132Keratoconus (HP:0000563)1.77861036
133Increased corneal curvature (HP:0100692)1.77861036
134Neoplasm of the tracheobronchial system (HP:0100552)1.77586313
135Sepsis (HP:0100806)1.77025421
136Abnormality of eosinophils (HP:0001879)1.76780121
137Glucose intolerance (HP:0000833)1.76661766
138Inability to walk (HP:0002540)1.76652633
139Thrombocytosis (HP:0001894)1.76296179
140Colon cancer (HP:0003003)1.76110663
141Excessive salivation (HP:0003781)1.76011858
142Abnormal pancreas size (HP:0012094)1.74472773
143Tubular atrophy (HP:0000092)1.74198648
144Facial diplegia (HP:0001349)1.72916607
145Recurrent abscess formation (HP:0002722)1.71429769
146Glioma (HP:0009733)1.71128434
147Thyroid carcinoma (HP:0002890)1.70088155
148Tubulointerstitial abnormality (HP:0001969)1.69728473
149Midline defect of the nose (HP:0004122)1.69565382
150Focal seizures (HP:0007359)1.69447834
151Milia (HP:0001056)1.68974616
152Abnormality of the columella (HP:0009929)1.68614672
153Combined immunodeficiency (HP:0005387)1.68215042
154Elevated erythrocyte sedimentation rate (HP:0003565)1.67050877
155Arterial thrombosis (HP:0004420)1.66452538
156Tetany (HP:0001281)1.65737953
157Abnormality of the astrocytes (HP:0100707)1.65317165
158Astrocytoma (HP:0009592)1.65317165
159Hypoplastic labia majora (HP:0000059)1.65002356
160Small hand (HP:0200055)1.64823816
161Abnormality of potassium homeostasis (HP:0011042)1.64701980
162Preaxial hand polydactyly (HP:0001177)1.64182044
163Bronchiectasis (HP:0002110)1.63559673
164Hemiparesis (HP:0001269)1.63117319
165Toxemia of pregnancy (HP:0100603)1.62880492
166Decreased central vision (HP:0007663)1.62705909
167Abnormality of chloride homeostasis (HP:0011422)1.62516178
168Methylmalonic acidemia (HP:0002912)1.61407926
169Chronic sinusitis (HP:0011109)1.60898720
170Renal tubular acidosis (HP:0001947)1.60348544
171Renal cortical cysts (HP:0000803)1.60046126
172Hypokalemic alkalosis (HP:0001949)1.59780105
173Metabolic alkalosis (HP:0200114)1.59478660
174Widely spaced teeth (HP:0000687)1.59256599
175Oculomotor apraxia (HP:0000657)1.59091157
176Preaxial foot polydactyly (HP:0001841)1.58869249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.00419378
2WNK32.64418604
3MAP4K22.64393819
4KIT2.48797098
5CASK2.29671994
6INSRR2.13709378
7AKT32.13619801
8TEC2.13380627
9TNIK2.08299038
10TGFBR22.04097665
11ZAK2.03514259
12PINK11.97488330
13FLT31.97260811
14NLK1.93055742
15TYK21.89786788
16CSF1R1.85777916
17MAP3K141.85066246
18BRD41.84443598
19MAP3K41.79485889
20BCR1.70496821
21NUAK11.69161779
22ADRBK21.65726796
23MAP3K101.65275385
24MAPK131.64175391
25BTK1.63942544
26FGFR31.57986476
27IRAK41.48866545
28STK391.42610638
29PDK31.42490890
30PDK41.42490890
31STK31.42365204
32EIF2AK31.42327307
33OXSR11.41056287
34NTRK31.40448389
35MST41.37852634
36NEK91.33052422
37PRKAA21.31890209
38SGK21.28930123
39TRPM71.28282958
40CAMK1D1.28270870
41STK38L1.27871883
42CAMK1G1.25476315
43EEF2K1.24222285
44JAK31.23836529
45LATS11.22742887
46TRIM281.22579268
47JAK11.22139945
48TAOK31.21309335
49ITK1.20965568
50HIPK21.17373841
51CDK91.16912049
52PNCK1.15328122
53SGK31.15199808
54CHUK1.14026575
55PTK61.12506052
56MAP3K71.12437242
57STK41.11732525
58MARK11.11467030
59CDK61.10952330
60PAK31.07828583
61RPS6KB21.07069456
62TGFBR11.02813787
63IKBKE1.01791198
64IKBKB1.01463601
65PIM11.00526483
66FGFR21.00286629
67MAP3K31.00125228
68STK241.00088563
69MUSK0.99911466
70TXK0.97942477
71BRSK20.97415432
72MAP3K20.94422022
73PIK3CA0.94005498
74PRKCE0.92453789
75IRAK10.92342541
76MAP4K10.91682901
77EIF2AK20.90783374
78PLK20.90033662
79DYRK1B0.88259549
80FER0.87111076
81DYRK30.87081201
82WNK10.84313703
83PIK3CG0.83690761
84ERBB30.83066276
85CSNK1G10.83016740
86SYK0.82625250
87TBK10.82520146
88ATR0.80505804
89DMPK0.78289556
90MAP2K30.76405269
91STK100.76051935
92VRK10.75147341
93CDK30.74997796
94OBSCN0.74310183
95SIK10.73925197
96YES10.73907614
97PDK20.73628954
98MAP3K130.73367011
99DAPK20.72518588
100LCK0.71980201
101TTN0.71527325
102MAPKAPK30.70341493
103MKNK10.68266990
104MAPK110.68220840
105CDK120.67989578
106PTK2B0.67486243
107LYN0.66856391
108MAPKAPK50.65979741
109ACVR1B0.64296071
110MAP2K70.64110496
111HCK0.62990256
112CSNK1G20.62364376
113EPHA30.61489684
114STK110.60402641
115PRKCQ0.59082478
116LRRK20.58757987
117IGF1R0.58471541
118FGFR40.58038144
119ZAP700.57845365
120PDGFRB0.57137751
121JAK20.57088435
122RPS6KB10.56544910
123CSNK1A1L0.56266337
124ERBB20.56185802
125SGK4940.56141703
126SGK2230.56141703
127ADRBK10.56070321
128BMPR1B0.55330277
129WNK40.55080257
130MKNK20.54709712
131CAMK40.53267537
132MAPK150.52227783
133GRK10.52080166
134TIE10.51462608
135IRAK30.51227391
136KSR10.51125161
137MELK0.51084568
138MARK20.51013535
139DYRK1A0.49396125
140PHKG20.47259714
141PHKG10.47259714
142CCNB10.46875408
143PRKCG0.46706781
144SGK10.46077776
145MAP2K40.44357715
146PKN10.43866349
147ATM0.43566494
148CAMK2A0.42162641
149PRKG10.41866856
150PRKAA10.41825132
151PLK40.41754280
152CSNK1G30.39813633
153CSNK1D0.39618351
154LMTK20.38962739
155EPHA40.38456101
156WEE10.36555412
157CAMKK20.32725476
158NTRK20.31691456
159PRKACA0.30966853

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.26805503
2Primary immunodeficiency_Homo sapiens_hsa053403.06492991
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.68337887
4B cell receptor signaling pathway_Homo sapiens_hsa046622.47398449
5Butanoate metabolism_Homo sapiens_hsa006502.24270345
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.16740772
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14357043
8Systemic lupus erythematosus_Homo sapiens_hsa053222.08483362
9Nicotine addiction_Homo sapiens_hsa050332.03601930
10Transcriptional misregulation in cancer_Homo sapiens_hsa052021.98448460
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95039951
12Lysine degradation_Homo sapiens_hsa003101.93392376
13Linoleic acid metabolism_Homo sapiens_hsa005911.90563781
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85148304
15Hematopoietic cell lineage_Homo sapiens_hsa046401.79799267
16Nitrogen metabolism_Homo sapiens_hsa009101.76482759
17Leishmaniasis_Homo sapiens_hsa051401.75605265
18Taste transduction_Homo sapiens_hsa047421.74127207
19Measles_Homo sapiens_hsa051621.73262989
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68426680
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66625232
22ABC transporters_Homo sapiens_hsa020101.66265770
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.66253612
24Osteoclast differentiation_Homo sapiens_hsa043801.65773708
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64017151
26Small cell lung cancer_Homo sapiens_hsa052221.60693547
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59174811
28Herpes simplex infection_Homo sapiens_hsa051681.57046023
29Tryptophan metabolism_Homo sapiens_hsa003801.56667278
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52707627
31Ether lipid metabolism_Homo sapiens_hsa005651.50374683
32Circadian entrainment_Homo sapiens_hsa047131.47404316
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45268159
34Toxoplasmosis_Homo sapiens_hsa051451.44720577
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44543012
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43710156
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.42311670
38Insulin secretion_Homo sapiens_hsa049111.41192908
39Olfactory transduction_Homo sapiens_hsa047401.41135537
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.36782935
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.36402050
42Propanoate metabolism_Homo sapiens_hsa006401.35241617
43Acute myeloid leukemia_Homo sapiens_hsa052211.34846297
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33661566
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30282234
46Chronic myeloid leukemia_Homo sapiens_hsa052201.29874778
47Glutamatergic synapse_Homo sapiens_hsa047241.29793534
48Retinol metabolism_Homo sapiens_hsa008301.26361750
49Chemical carcinogenesis_Homo sapiens_hsa052041.26152827
50Regulation of autophagy_Homo sapiens_hsa041401.24660897
51Influenza A_Homo sapiens_hsa051641.23650588
52TNF signaling pathway_Homo sapiens_hsa046681.23114092
53Malaria_Homo sapiens_hsa051441.22841390
54Salivary secretion_Homo sapiens_hsa049701.21480148
55Serotonergic synapse_Homo sapiens_hsa047261.18898130
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16900944
57Renin secretion_Homo sapiens_hsa049241.16091580
58Fanconi anemia pathway_Homo sapiens_hsa034601.15342887
59Morphine addiction_Homo sapiens_hsa050321.14809916
60Histidine metabolism_Homo sapiens_hsa003401.12928448
61beta-Alanine metabolism_Homo sapiens_hsa004101.10861473
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10272926
63Amphetamine addiction_Homo sapiens_hsa050311.09470584
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08922383
65Calcium signaling pathway_Homo sapiens_hsa040201.08874316
66Homologous recombination_Homo sapiens_hsa034401.08859968
67Gastric acid secretion_Homo sapiens_hsa049711.07789329
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07740008
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07477823
70Prostate cancer_Homo sapiens_hsa052151.04458287
71Antigen processing and presentation_Homo sapiens_hsa046121.04188931
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01983649
73Hepatitis B_Homo sapiens_hsa051611.01820841
74Insulin resistance_Homo sapiens_hsa049311.01359285
75Long-term depression_Homo sapiens_hsa047301.00329792
76Platelet activation_Homo sapiens_hsa046110.99924650
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97548871
78Pancreatic cancer_Homo sapiens_hsa052120.97066163
79Fatty acid degradation_Homo sapiens_hsa000710.96085612
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96054588
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.95387190
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94658338
83Dopaminergic synapse_Homo sapiens_hsa047280.93750493
84GABAergic synapse_Homo sapiens_hsa047270.93529075
85FoxO signaling pathway_Homo sapiens_hsa040680.91569389
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90810414
87T cell receptor signaling pathway_Homo sapiens_hsa046600.90555032
88cAMP signaling pathway_Homo sapiens_hsa040240.90553465
89MicroRNAs in cancer_Homo sapiens_hsa052060.90530738
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89097334
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88828692
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88741917
93Protein export_Homo sapiens_hsa030600.87144346
94Protein digestion and absorption_Homo sapiens_hsa049740.87025535
95Circadian rhythm_Homo sapiens_hsa047100.87006844
96Viral carcinogenesis_Homo sapiens_hsa052030.86120441
97Legionellosis_Homo sapiens_hsa051340.83958431
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.83185718
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82162101
100Basal transcription factors_Homo sapiens_hsa030220.81839026
101Hepatitis C_Homo sapiens_hsa051600.81319389
102ECM-receptor interaction_Homo sapiens_hsa045120.81136027
103Thyroid cancer_Homo sapiens_hsa052160.80067197
104Graft-versus-host disease_Homo sapiens_hsa053320.80022872
105Oxytocin signaling pathway_Homo sapiens_hsa049210.79987193
106Inositol phosphate metabolism_Homo sapiens_hsa005620.79963257
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79318354
108Staphylococcus aureus infection_Homo sapiens_hsa051500.77985316
109Allograft rejection_Homo sapiens_hsa053300.77408371
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76913351
111Cholinergic synapse_Homo sapiens_hsa047250.76893726
112Melanoma_Homo sapiens_hsa052180.75793326
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75259534
114Non-small cell lung cancer_Homo sapiens_hsa052230.74792373
115Caffeine metabolism_Homo sapiens_hsa002320.73944926
116Tuberculosis_Homo sapiens_hsa051520.73380214
117Dorso-ventral axis formation_Homo sapiens_hsa043200.72689316
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.72560106
119African trypanosomiasis_Homo sapiens_hsa051430.71890230
120Pertussis_Homo sapiens_hsa051330.71398892
121Pancreatic secretion_Homo sapiens_hsa049720.70766782
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70270700
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69163909
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69129990
125Selenocompound metabolism_Homo sapiens_hsa004500.68743141
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67814530
127Adherens junction_Homo sapiens_hsa045200.67775414
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65340113
129Glycerolipid metabolism_Homo sapiens_hsa005610.64833996
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64612823
131Focal adhesion_Homo sapiens_hsa045100.64610482
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63321868
133HTLV-I infection_Homo sapiens_hsa051660.63065899
134Arachidonic acid metabolism_Homo sapiens_hsa005900.63058513
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63028664
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62323373
137Peroxisome_Homo sapiens_hsa041460.62280683
138Vitamin digestion and absorption_Homo sapiens_hsa049770.62030947
139Alcoholism_Homo sapiens_hsa050340.61357421
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61263126
141Phototransduction_Homo sapiens_hsa047440.61251332
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60753147
143Amoebiasis_Homo sapiens_hsa051460.60635564
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58056766
145Chemokine signaling pathway_Homo sapiens_hsa040620.55656558
146Pathways in cancer_Homo sapiens_hsa052000.55190809
147Cocaine addiction_Homo sapiens_hsa050300.54755563
148Fatty acid biosynthesis_Homo sapiens_hsa000610.54152935
149Hedgehog signaling pathway_Homo sapiens_hsa043400.53572923
150RNA degradation_Homo sapiens_hsa030180.53538178
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52080052
152TGF-beta signaling pathway_Homo sapiens_hsa043500.51700778
153Renin-angiotensin system_Homo sapiens_hsa046140.51328960
154Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49299693
155Proteoglycans in cancer_Homo sapiens_hsa052050.49191192
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.48732464
157Type II diabetes mellitus_Homo sapiens_hsa049300.46804640
158Complement and coagulation cascades_Homo sapiens_hsa046100.46503483
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46373866
160Fatty acid metabolism_Homo sapiens_hsa012120.46037890
161Viral myocarditis_Homo sapiens_hsa054160.45488693
162PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45103951
163Apoptosis_Homo sapiens_hsa042100.44906220
164Sphingolipid metabolism_Homo sapiens_hsa006000.44304431
165Mineral absorption_Homo sapiens_hsa049780.44290767
166Glucagon signaling pathway_Homo sapiens_hsa049220.43431604
167Cyanoamino acid metabolism_Homo sapiens_hsa004600.43065826
168Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42438174
169Ovarian steroidogenesis_Homo sapiens_hsa049130.41527382
170Wnt signaling pathway_Homo sapiens_hsa043100.41235367
171PPAR signaling pathway_Homo sapiens_hsa033200.41199659
172Notch signaling pathway_Homo sapiens_hsa043300.40077269
173Choline metabolism in cancer_Homo sapiens_hsa052310.39417768
174Endometrial cancer_Homo sapiens_hsa052130.37660904

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