KARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1IMP biosynthetic process (GO:0006188)4.87072294
2DNA strand elongation involved in DNA replication (GO:0006271)4.79146854
3DNA unwinding involved in DNA replication (GO:0006268)4.69950483
4nucleobase biosynthetic process (GO:0046112)4.69481696
5DNA strand elongation (GO:0022616)4.57239348
6DNA replication initiation (GO:0006270)4.54999705
7protein localization to kinetochore (GO:0034501)4.52063601
8regulation of translational fidelity (GO:0006450)4.51561588
9purine nucleobase biosynthetic process (GO:0009113)4.49347958
10formation of translation preinitiation complex (GO:0001731)4.48043180
11ribosomal small subunit biogenesis (GO:0042274)4.46434824
12telomere maintenance via semi-conservative replication (GO:0032201)4.41932812
13mitotic metaphase plate congression (GO:0007080)4.38346212
14ribosomal small subunit assembly (GO:0000028)4.37583150
15IMP metabolic process (GO:0046040)4.23491389
16mitotic nuclear envelope disassembly (GO:0007077)4.16274489
17nuclear pore organization (GO:0006999)4.12919536
18establishment of viral latency (GO:0019043)4.08130118
19folic acid-containing compound biosynthetic process (GO:0009396)4.05255137
20telomere maintenance via recombination (GO:0000722)3.99751846
21DNA replication checkpoint (GO:0000076)3.92244792
22mitotic recombination (GO:0006312)3.87854105
23maturation of SSU-rRNA (GO:0030490)3.86383231
24ribosome biogenesis (GO:0042254)3.84055794
25membrane disassembly (GO:0030397)3.83121354
26nuclear envelope disassembly (GO:0051081)3.83121354
27protein localization to chromosome, centromeric region (GO:0071459)3.81660630
28nuclear pore complex assembly (GO:0051292)3.80636820
29metaphase plate congression (GO:0051310)3.76644405
30CENP-A containing nucleosome assembly (GO:0034080)3.76490058
31chromatin remodeling at centromere (GO:0031055)3.72392638
32telomere maintenance via telomere lengthening (GO:0010833)3.69284674
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68712827
34nucleobase-containing small molecule interconversion (GO:0015949)3.67183937
35DNA replication-dependent nucleosome organization (GO:0034723)3.67076829
36DNA replication-dependent nucleosome assembly (GO:0006335)3.67076829
37* tRNA aminoacylation for protein translation (GO:0006418)3.66331603
38kinetochore organization (GO:0051383)3.62100607
39cotranslational protein targeting to membrane (GO:0006613)3.61069986
40* amino acid activation (GO:0043038)3.58922507
41* tRNA aminoacylation (GO:0043039)3.58922507
42protein targeting to ER (GO:0045047)3.58416585
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.56290663
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55280625
45mitotic sister chromatid segregation (GO:0000070)3.51125261
46attachment of spindle microtubules to kinetochore (GO:0008608)3.48924379
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.48868340
48ribonucleoprotein complex biogenesis (GO:0022613)3.47845010
49establishment of chromosome localization (GO:0051303)3.46761898
50ribosomal large subunit biogenesis (GO:0042273)3.46616733
51regulation of spindle organization (GO:0090224)3.45683643
52DNA replication-independent nucleosome organization (GO:0034724)3.45086623
53DNA replication-independent nucleosome assembly (GO:0006336)3.45086623
54peptidyl-arginine omega-N-methylation (GO:0035247)3.42256728
55regulation of translational termination (GO:0006449)3.41680652
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39606082
57protein localization to endoplasmic reticulum (GO:0070972)3.37496905
58mitotic chromosome condensation (GO:0007076)3.34725740
59translation (GO:0006412)3.31742729
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.30588324
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.30588324
62ribosome assembly (GO:0042255)3.30472690
63DNA duplex unwinding (GO:0032508)3.27078388
64kinetochore assembly (GO:0051382)3.25998583
65DNA geometric change (GO:0032392)3.25657227
66viral life cycle (GO:0019058)3.23718343
67sister chromatid segregation (GO:0000819)3.21417116
68spliceosomal snRNP assembly (GO:0000387)3.20316635
69proteasome assembly (GO:0043248)3.20142457
70COPI coating of Golgi vesicle (GO:0048205)3.20051169
71Golgi transport vesicle coating (GO:0048200)3.20051169
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15606309
73histone exchange (GO:0043486)3.14788680
74non-recombinational repair (GO:0000726)3.14372484
75double-strand break repair via nonhomologous end joining (GO:0006303)3.14372484
76DNA ligation (GO:0006266)3.14146569
77rRNA processing (GO:0006364)3.13534638
78regulation of mitochondrial translation (GO:0070129)3.12613192
79transcription-coupled nucleotide-excision repair (GO:0006283)3.11877531
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10438679
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09947459
82pore complex assembly (GO:0046931)3.09357585
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08381670
84negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08010145
85L-serine metabolic process (GO:0006563)3.07369974
86cellular protein complex disassembly (GO:0043624)3.07038093
87G1/S transition of mitotic cell cycle (GO:0000082)3.06232693
88cell cycle G1/S phase transition (GO:0044843)3.06232693
89histone arginine methylation (GO:0034969)3.04735473
90cellular component biogenesis (GO:0044085)3.04698063
91rRNA metabolic process (GO:0016072)3.04266733
92positive regulation of chromosome segregation (GO:0051984)3.03400306
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03137792
94telomere maintenance (GO:0000723)3.02971193
95telomere organization (GO:0032200)3.02388488
96establishment of integrated proviral latency (GO:0075713)3.00977210
97pteridine-containing compound biosynthetic process (GO:0042559)3.00671949
98regulation of translational elongation (GO:0006448)2.99717914
99negative regulation of chromosome segregation (GO:0051985)2.99304089
100spindle checkpoint (GO:0031577)2.98876922
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98180155
102negative regulation of sister chromatid segregation (GO:0033046)2.98180155
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.98180155
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98180155
105regulation of double-strand break repair via homologous recombination (GO:0010569)2.97750131
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97006761
107proline biosynthetic process (GO:0006561)2.96328700
108translational initiation (GO:0006413)2.96203888
109DNA topological change (GO:0006265)2.93629142
110oxidative phosphorylation (GO:0006119)2.93585229
111meiotic chromosome segregation (GO:0045132)2.93554308
112nuclear envelope organization (GO:0006998)2.92132813
113rRNA modification (GO:0000154)2.92078015
114regulation of posttranscriptional gene silencing (GO:0060147)2.92002470
115regulation of gene silencing by miRNA (GO:0060964)2.92002470
116regulation of gene silencing by RNA (GO:0060966)2.92002470
117protein complex localization (GO:0031503)2.91882844
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91387402
119spindle assembly checkpoint (GO:0071173)2.91383710
120viral transcription (GO:0019083)2.90314350
121snRNA processing (GO:0016180)2.90048328
122translational termination (GO:0006415)2.89315849
123mitotic spindle assembly checkpoint (GO:0007094)2.89147641
124mismatch repair (GO:0006298)2.89008640
125regulation of mitotic spindle organization (GO:0060236)2.88941598
126regulation of chromosome segregation (GO:0051983)2.88429670
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88122963
128transcription from mitochondrial promoter (GO:0006390)2.87786537
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.87028739
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87028739
131translational elongation (GO:0006414)2.86626713
132mitotic spindle checkpoint (GO:0071174)2.86583229
133cullin deneddylation (GO:0010388)2.86539479
134protein complex disassembly (GO:0043241)2.86222299
135negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86070751
136negative regulation of ligase activity (GO:0051352)2.86070751
137positive regulation of ligase activity (GO:0051351)2.85601660
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85574621
139viral mRNA export from host cell nucleus (GO:0046784)2.84087076
140signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83831793
141intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83831793
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83770316
143signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83719921
144signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83719921
145signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83719921
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.82759951
147RNA splicing, via transesterification reactions (GO:0000375)2.81870015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.78703016
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.37373487
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.95538928
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73350532
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64546367
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18833205
7* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11376441
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05094767
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.99188570
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93364330
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83454124
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76663205
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.72132472
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66748276
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.63544565
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51708595
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44151861
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31603025
19* XRN2_22483619_ChIP-Seq_HELA_Human2.31222910
20AR_21909140_ChIP-Seq_LNCAP_Human2.17696720
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16317104
22* VDR_23849224_ChIP-Seq_CD4+_Human2.11020363
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09798270
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.05544119
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04474362
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01833353
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01115564
28FOXP3_21729870_ChIP-Seq_TREG_Human1.98872992
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.95984627
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94120752
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93616455
32DCP1A_22483619_ChIP-Seq_HELA_Human1.93265171
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92863430
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92806652
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91253034
36ZNF263_19887448_ChIP-Seq_K562_Human1.82043774
37* GABP_19822575_ChIP-Seq_HepG2_Human1.80901139
38TTF2_22483619_ChIP-Seq_HELA_Human1.77702834
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75114235
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72969388
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72002389
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.65537053
43CIITA_25753668_ChIP-Seq_RAJI_Human1.61928694
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60501510
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60347252
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59206275
47ELK1_19687146_ChIP-ChIP_HELA_Human1.56819886
48MYC_22102868_ChIP-Seq_BL_Human1.54157223
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50918574
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50163453
51KDM5A_27292631_Chip-Seq_BREAST_Human1.49892843
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49310473
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45463747
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45413125
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43122516
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42532937
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.37411010
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33326463
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31141417
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31135648
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26777769
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25336068
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.24389615
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22766213
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22007706
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21021961
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20452662
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19714004
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18867228
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16905556
71TFEB_21752829_ChIP-Seq_HELA_Human1.14698476
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13986798
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13270406
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13196333
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12865850
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11102809
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10325071
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07143442
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06957780
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06245667
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05384998
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03486820
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02291126
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01321733
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99132154
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99101283
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96340709
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95750828
89* SOX17_20123909_ChIP-Seq_XEN_Mouse0.95236987
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94269847
91MYC_18940864_ChIP-ChIP_HL60_Human0.93388403
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.91454113
93SALL1_21062744_ChIP-ChIP_HESCs_Human0.91265226
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90485191
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90399952
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90367393
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89693643
98TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89643527
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88984149
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88662506
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88221673
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88206918
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87694900
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86139379
105CHD1_26751641_Chip-Seq_LNCaP_Human0.86078183
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86023950
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83890240
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82827866
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82487210
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82146202
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81800988
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.81541574
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80147100
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.79829286

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.18168311
2MP0010094_abnormal_chromosome_stability4.80593676
3MP0003111_abnormal_nucleus_morphology4.43618581
4MP0004957_abnormal_blastocyst_morpholog4.25677011
5MP0003077_abnormal_cell_cycle3.96077527
6MP0008057_abnormal_DNA_replication3.72672435
7MP0008058_abnormal_DNA_repair3.46959465
8MP0008007_abnormal_cellular_replicative3.07435235
9MP0010352_gastrointestinal_tract_polyps2.64103810
10MP0008932_abnormal_embryonic_tissue2.61848847
11MP0003123_paternal_imprinting2.58707414
12MP0001730_embryonic_growth_arrest2.53802765
13MP0002396_abnormal_hematopoietic_system2.52525167
14MP0000350_abnormal_cell_proliferation2.33931475
15MP0008877_abnormal_DNA_methylation2.02215891
16MP0003786_premature_aging1.98704572
17MP0005380_embryogenesis_phenotype1.90647922
18MP0001672_abnormal_embryogenesis/_devel1.90647922
19MP0010234_abnormal_vibrissa_follicle1.88936777
20MP0001697_abnormal_embryo_size1.85625171
21MP0005451_abnormal_body_composition1.83455345
22MP0010307_abnormal_tumor_latency1.83343948
23MP0010030_abnormal_orbit_morphology1.83297044
24MP0003984_embryonic_growth_retardation1.75234087
25MP0002088_abnormal_embryonic_growth/wei1.71336691
26MP0002080_prenatal_lethality1.66348044
27MP0003806_abnormal_nucleotide_metabolis1.62870530
28MP0004197_abnormal_fetal_growth/weight/1.62596422
29MP0002085_abnormal_embryonic_tissue1.58570643
30MP0000490_abnormal_crypts_of1.57042168
31MP0003567_abnormal_fetal_cardiomyocyte1.56154276
32MP0005501_abnormal_skin_physiology1.50698463
33MP0002084_abnormal_developmental_patter1.50611316
34MP0002086_abnormal_extraembryonic_tissu1.48637543
35MP0003121_genomic_imprinting1.47507879
36MP0001853_heart_inflammation1.46526392
37MP0009053_abnormal_anal_canal1.45563509
38MP0004808_abnormal_hematopoietic_stem1.43284996
39MP0000313_abnormal_cell_death1.43162337
40MP0002796_impaired_skin_barrier1.38766707
41MP0003890_abnormal_embryonic-extraembry1.37159954
42MP0002019_abnormal_tumor_incidence1.35492830
43MP0003718_maternal_effect1.33459724
44MP0003705_abnormal_hypodermis_morpholog1.25512105
45MP0001661_extended_life_span1.25470724
46MP0006054_spinal_hemorrhage1.24560027
47MP0001293_anophthalmia1.18046609
48MP0009379_abnormal_foot_pigmentation1.17492507
49MP0004185_abnormal_adipocyte_glucose1.15390142
50MP0003186_abnormal_redox_activity1.07064474
51MP0000537_abnormal_urethra_morphology1.06470571
52MP0002210_abnormal_sex_determination1.06204760
53MP0003315_abnormal_perineum_morphology1.05935847
54MP0009672_abnormal_birth_weight1.05367361
55MP0008260_abnormal_autophagy1.05096107
56MP0004133_heterotaxia1.04750824
57MP0000358_abnormal_cell_content/1.04299727
58MP0001881_abnormal_mammary_gland1.04128798
59MP0009333_abnormal_splenocyte_physiolog1.03103626
60MP0005076_abnormal_cell_differentiation1.02467384
61MP0003119_abnormal_digestive_system1.02211119
62MP0002111_abnormal_tail_morphology0.98866697
63MP0005023_abnormal_wound_healing0.94087862
64MP0002160_abnormal_reproductive_system0.91958644
65MP0001727_abnormal_embryo_implantation0.91874172
66MP0005397_hematopoietic_system_phenotyp0.91712594
67MP0001545_abnormal_hematopoietic_system0.91712594
68MP0000858_altered_metastatic_potential0.91350365
69MP0001145_abnormal_male_reproductive0.91316564
70MP0005408_hypopigmentation0.90158314
71MP0002653_abnormal_ependyma_morphology0.90148101
72MP0003763_abnormal_thymus_physiology0.90136762
73MP0000703_abnormal_thymus_morphology0.89945524
74MP0003221_abnormal_cardiomyocyte_apopto0.86719391
75MP0005330_cardiomyopathy0.85168657
76MP0001915_intracranial_hemorrhage0.84011772
77MP0005384_cellular_phenotype0.83658550
78MP0001216_abnormal_epidermal_layer0.82357416
79MP0001119_abnormal_female_reproductive0.81916559
80MP0003566_abnormal_cell_adhesion0.81263764
81MP0009703_decreased_birth_body0.80681371
82MP0006292_abnormal_olfactory_placode0.79744822
83MP0000653_abnormal_sex_gland0.78518507
84MP0002060_abnormal_skin_morphology0.77685558
85MP0001346_abnormal_lacrimal_gland0.75728172
86MP0002722_abnormal_immune_system0.75191617
87MP0002398_abnormal_bone_marrow0.74840890
88MP0003941_abnormal_skin_development0.74473826
89MP0000627_abnormal_mammary_gland0.74065492
90MP0003656_abnormal_erythrocyte_physiolo0.72092100
91MP0003942_abnormal_urinary_system0.72025585
92MP0001929_abnormal_gametogenesis0.71668022
93MP0003937_abnormal_limbs/digits/tail_de0.71583157
94MP0005621_abnormal_cell_physiology0.71573224
95MP0000747_muscle_weakness0.71079543
96MP0000689_abnormal_spleen_morphology0.70936816
97MP0002877_abnormal_melanocyte_morpholog0.70402934
98MP0001286_abnormal_eye_development0.70196517
99MP0004233_abnormal_muscle_weight0.69568008
100MP0002697_abnormal_eye_size0.69556637
101MP0003115_abnormal_respiratory_system0.69233341
102MP0000516_abnormal_urinary_system0.68844541
103MP0005367_renal/urinary_system_phenotyp0.68844541
104MP0004782_abnormal_surfactant_physiolog0.67862221
105MP0004084_abnormal_cardiac_muscle0.67563544
106MP0005266_abnormal_metabolism0.65681458
107MP0003943_abnormal_hepatobiliary_system0.65659754
108MP0006036_abnormal_mitochondrial_physio0.65353748
109MP0005389_reproductive_system_phenotype0.64786852
110MP0002269_muscular_atrophy0.63824566
111MP0002163_abnormal_gland_morphology0.63480285
112MP0002006_tumorigenesis0.63337655
113MP0006035_abnormal_mitochondrial_morpho0.63238405
114MP0001849_ear_inflammation0.62420635
115MP0002132_abnormal_respiratory_system0.62380237
116MP0004264_abnormal_extraembryonic_tissu0.62265014
117MP0003453_abnormal_keratinocyte_physiol0.61986576
118MP0000678_abnormal_parathyroid_gland0.59453381
119MP0003300_gastrointestinal_ulcer0.59344823
120MP0010630_abnormal_cardiac_muscle0.59271350
121MP0000598_abnormal_liver_morphology0.58721765
122MP0000477_abnormal_intestine_morphology0.58683351
123MP0002127_abnormal_cardiovascular_syste0.58680801
124MP0000750_abnormal_muscle_regeneration0.58463809
125MP0002429_abnormal_blood_cell0.58400035
126MP0009697_abnormal_copulation0.58063604
127MP0002938_white_spotting0.57901614
128MP0000049_abnormal_middle_ear0.57753194
129MP0009931_abnormal_skin_appearance0.56153210
130MP0001529_abnormal_vocalization0.55307803
131MP0000377_abnormal_hair_follicle0.55305689
132MP0004087_abnormal_muscle_fiber0.54428642

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.93537336
2Abnormality of the anterior horn cell (HP:0006802)4.60357583
3Degeneration of anterior horn cells (HP:0002398)4.60357583
4Abnormality of glycolysis (HP:0004366)3.98138465
5Increased serum pyruvate (HP:0003542)3.62559044
6Colon cancer (HP:0003003)3.59922477
7Chromsome breakage (HP:0040012)3.49177488
8Patellar aplasia (HP:0006443)3.45944676
9Progressive muscle weakness (HP:0003323)3.45257054
10Ependymoma (HP:0002888)3.37879484
11Breast hypoplasia (HP:0003187)3.36174998
12Abnormality of cells of the erythroid lineage (HP:0012130)3.33962203
13Aplasia/Hypoplasia of the patella (HP:0006498)3.27932802
14Abnormal gallbladder physiology (HP:0012438)3.27181771
15Cholecystitis (HP:0001082)3.27181771
16Reticulocytopenia (HP:0001896)3.26670402
17Medulloblastoma (HP:0002885)3.24148708
18Oral leukoplakia (HP:0002745)3.23776980
19Carpal bone hypoplasia (HP:0001498)3.20523148
20Selective tooth agenesis (HP:0001592)3.19636663
21Aplastic anemia (HP:0001915)3.18239225
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13484319
23Progressive external ophthalmoplegia (HP:0000590)3.09570783
24Abnormal number of erythroid precursors (HP:0012131)2.99943865
2511 pairs of ribs (HP:0000878)2.93844559
26Agnosia (HP:0010524)2.88153025
27Absent thumb (HP:0009777)2.87757689
28Meckel diverticulum (HP:0002245)2.85605644
29Abnormality of chromosome stability (HP:0003220)2.83096154
30Cerebral hypomyelination (HP:0006808)2.82986764
31Ragged-red muscle fibers (HP:0003200)2.78714695
32Atrophy/Degeneration involving motor neurons (HP:0007373)2.72528056
33Abnormality of the ileum (HP:0001549)2.70862312
34Cortical dysplasia (HP:0002539)2.69874622
35Impulsivity (HP:0100710)2.64495942
36Increased hepatocellular lipid droplets (HP:0006565)2.63583774
37Abnormality of the preputium (HP:0100587)2.62735890
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61660323
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61660323
40Rough bone trabeculation (HP:0100670)2.60832068
41Abnormal lung lobation (HP:0002101)2.60827700
42Abnormality of reticulocytes (HP:0004312)2.56398271
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55334345
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.54814448
45Rhabdomyosarcoma (HP:0002859)2.52321741
46Lipid accumulation in hepatocytes (HP:0006561)2.49409662
47Myelodysplasia (HP:0002863)2.47818206
48Abnormal mitochondria in muscle tissue (HP:0008316)2.47311609
49Abnormality of the labia minora (HP:0012880)2.45000731
50Abnormality of methionine metabolism (HP:0010901)2.42817876
51Reduced antithrombin III activity (HP:0001976)2.41965267
52Type I transferrin isoform profile (HP:0003642)2.41653553
53Increased serum lactate (HP:0002151)2.41621491
54Abnormal number of incisors (HP:0011064)2.39876439
55Neoplasm of the pancreas (HP:0002894)2.39620182
56Duodenal stenosis (HP:0100867)2.38911061
57Small intestinal stenosis (HP:0012848)2.38911061
58Acute encephalopathy (HP:0006846)2.37772627
59Missing ribs (HP:0000921)2.37043605
60Increased intramyocellular lipid droplets (HP:0012240)2.34546491
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34491222
62Spastic diplegia (HP:0001264)2.34388848
63Basal cell carcinoma (HP:0002671)2.31900020
64Abnormality of the calcaneus (HP:0008364)2.31341704
65Acute necrotizing encephalopathy (HP:0006965)2.30743741
66Bone marrow hypocellularity (HP:0005528)2.26604969
67Trismus (HP:0000211)2.26496746
68Hepatocellular necrosis (HP:0001404)2.24708511
69Absent radius (HP:0003974)2.23671974
70Overlapping toe (HP:0001845)2.23121439
71Premature graying of hair (HP:0002216)2.21641648
72Deviation of the thumb (HP:0009603)2.20986378
73Exercise intolerance (HP:0003546)2.20642836
74Pancytopenia (HP:0001876)2.19818030
75Increased CSF lactate (HP:0002490)2.18900114
76Abnormality of the astrocytes (HP:0100707)2.17723962
77Astrocytoma (HP:0009592)2.17723962
78Hepatic necrosis (HP:0002605)2.17626214
79Sloping forehead (HP:0000340)2.17243805
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14692361
81Cutaneous melanoma (HP:0012056)2.13779638
82Spinal muscular atrophy (HP:0007269)2.13117061
83Rhabdomyolysis (HP:0003201)2.13036470
84Microvesicular hepatic steatosis (HP:0001414)2.12711325
85Lactic acidosis (HP:0003128)2.12688705
86Slender long bone (HP:0003100)2.12473428
87Abnormality of the umbilical cord (HP:0010881)2.11675358
88Aplasia/Hypoplasia of the sternum (HP:0006714)2.10952275
89Cerebral edema (HP:0002181)2.10934546
90Atresia of the external auditory canal (HP:0000413)2.10489924
91Nephroblastoma (Wilms tumor) (HP:0002667)2.09924037
92Increased muscle lipid content (HP:0009058)2.07262991
93Premature ovarian failure (HP:0008209)2.06532031
94Neoplasm of the colon (HP:0100273)2.06493562
95Ectopic kidney (HP:0000086)2.06120722
96Glioma (HP:0009733)2.05553145
97Multiple enchondromatosis (HP:0005701)2.03938703
98Cellular immunodeficiency (HP:0005374)2.03486924
99Proximal placement of thumb (HP:0009623)2.03146469
100Microretrognathia (HP:0000308)2.02110047
101Embryonal renal neoplasm (HP:0011794)2.01915122
102Absent forearm bone (HP:0003953)2.01422453
103Aplasia involving forearm bones (HP:0009822)2.01422453
104Squamous cell carcinoma (HP:0002860)2.00786738
105Abnormality of the duodenum (HP:0002246)2.00352978
106Ovarian neoplasm (HP:0100615)2.00075073
107Horseshoe kidney (HP:0000085)1.99990346
108Centrally nucleated skeletal muscle fibers (HP:0003687)1.99243228
109Amaurosis fugax (HP:0100576)1.99057795
110Abnormalities of placenta or umbilical cord (HP:0001194)1.98743679
111Cafe-au-lait spot (HP:0000957)1.96712456
112Mitochondrial inheritance (HP:0001427)1.96656784
113Respiratory difficulties (HP:0002880)1.96653660
114Secondary amenorrhea (HP:0000869)1.96041195
115Biliary tract neoplasm (HP:0100574)1.94709423
116Gout (HP:0001997)1.93001603
117Sparse eyelashes (HP:0000653)1.92230190
118Entropion (HP:0000621)1.92023008
119Thrombocytosis (HP:0001894)1.91976535
120Cholelithiasis (HP:0001081)1.91272948
121Tracheoesophageal fistula (HP:0002575)1.90796016
122Macrocytic anemia (HP:0001972)1.90487803
123Shoulder girdle muscle weakness (HP:0003547)1.90029011
124Facial cleft (HP:0002006)1.88582958
125Abnormal glycosylation (HP:0012345)1.87780074
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87780074
127Abnormal protein N-linked glycosylation (HP:0012347)1.87780074
128Abnormal protein glycosylation (HP:0012346)1.87780074
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86841119
130Increased nuchal translucency (HP:0010880)1.86738053
131Glossoptosis (HP:0000162)1.86029953
132Testicular atrophy (HP:0000029)1.85211228
133Reticulocytosis (HP:0001923)1.85022936
134Prominent metopic ridge (HP:0005487)1.83743389
135Short 4th metacarpal (HP:0010044)1.83317760
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83317760
137Abnormal trabecular bone morphology (HP:0100671)1.82563271
138Pallor (HP:0000980)1.82012677
139Myoglobinuria (HP:0002913)1.81650211
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80150809
141Absent epiphyses (HP:0010577)1.80150809
142Triphalangeal thumb (HP:0001199)1.79452879
143Abnormality of pyrimidine metabolism (HP:0004353)1.77575226
144Nemaline bodies (HP:0003798)1.76749814
145Angiofibromas (HP:0010615)1.76419596
146Adenoma sebaceum (HP:0009720)1.76419596
147Aplasia/hypoplasia of the humerus (HP:0006507)1.76256811
148Megaloblastic anemia (HP:0001889)1.74468450
149Irregular epiphyses (HP:0010582)1.73690946
150Upper limb muscle weakness (HP:0003484)1.72061179
151Rectal fistula (HP:0100590)1.71690374
152Rectovaginal fistula (HP:0000143)1.71690374
153Stenosis of the external auditory canal (HP:0000402)1.71564660
154Abnormality of the metopic suture (HP:0005556)1.71466351
155Amniotic constriction ring (HP:0009775)1.71016487
156Abnormality of placental membranes (HP:0011409)1.71016487
157Postnatal microcephaly (HP:0005484)1.70658740
158High pitched voice (HP:0001620)1.70516665
159Pelvic girdle muscle weakness (HP:0003749)1.70106916
160Death in infancy (HP:0001522)1.69694072
161Neoplasm of striated muscle (HP:0009728)1.67075202
162Abnormal umbilical cord blood vessels (HP:0011403)1.66652312
163Single umbilical artery (HP:0001195)1.66652312
164Abnormality of the fetal cardiovascular system (HP:0010948)1.66652312
165Orthostatic hypotension (HP:0001278)1.64625491
166Abnormal gallbladder morphology (HP:0012437)1.63761864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.42011306
2CDC74.23572664
3WEE13.77588057
4EIF2AK13.66101310
5VRK23.54257378
6PBK3.44172015
7TSSK62.81448535
8NEK12.79429610
9SRPK12.56374022
10PASK2.48919883
11NEK22.33427247
12SMG12.31512643
13MKNK12.23709146
14PLK42.18801768
15BRSK22.10251183
16TTK2.04983849
17EIF2AK32.03860559
18PLK31.99744269
19PLK11.90779500
20IRAK31.87867427
21VRK11.82591182
22RPS6KB21.76426852
23ATR1.69001351
24CDK71.66256068
25TGFBR11.65973429
26STK161.57232234
27NME21.57063349
28AURKB1.56863870
29ACVR1B1.56455790
30EEF2K1.53648790
31ZAK1.46079576
32MKNK21.45758272
33BRSK11.44620665
34TESK21.39225011
35EPHA21.34439150
36FLT31.32408390
37PDK21.29527149
38CHEK21.26361351
39CCNB11.26100583
40PKN21.25622628
41RPS6KA41.23730158
42CHEK11.21806907
43MAP3K81.18947421
44TLK11.16023059
45MST41.15119520
46AURKA1.15020972
47PIM21.11503046
48CDK121.09262967
49STK41.08428619
50PAK41.06227506
51CDK41.05156558
52MST1R0.99761794
53MAP2K30.99677718
54STK100.97960747
55TAF10.97574855
56TESK10.94886988
57EIF2AK20.93674722
58DYRK30.88484095
59PIM10.86962494
60ATM0.85099643
61CDK20.84379312
62ALK0.82875098
63STK38L0.80430316
64SCYL20.78979323
65TRIB30.78976964
66ERBB40.78546871
67ICK0.77475588
68ARAF0.75407572
69MAP3K100.72121010
70CDK80.70162727
71CSNK2A20.68728637
72CSNK2A10.68666725
73PAK10.68503921
74BRAF0.68202904
75RAF10.66818437
76TRIM280.64032865
77CDK10.62987157
78ILK0.62426636
79NEK90.61901860
80MAP3K30.59168845
81DAPK10.58978515
82PRKCI0.58303275
83LRRK20.56531241
84STK240.55592653
85BCKDK0.55093736
86AKT20.52687679
87STK30.51560061
88LIMK10.51382567
89AKT30.50578236
90MAP4K10.50238029
91CDK90.50147390
92RPS6KL10.48667085
93RPS6KC10.48667085
94KSR20.48311346
95FGFR40.46645063
96MAPKAPK30.46190618
97RPS6KA60.46043855
98MAP3K120.45947824
99PDK40.45887983
100PDK30.45887983
101KDR0.45615702
102LATS20.45342596
103CLK10.45177750
104CDK190.44565832
105BRD40.44448447
106CDK60.44425361
107PIK3CG0.43643646
108PNCK0.42369632
109RPS6KB10.40914809
110MELK0.39982052
111ERBB30.39692544
112NME10.37602043
113CDK11A0.37149882
114CDK140.35615480
115FGFR10.35424700
116TTN0.34617911
117TAOK20.32933694
118MTOR0.32908281
119CDK180.32131471
120CSNK1E0.31595604
121CDK150.31093973
122PAK20.31086737
123MAPKAPK50.31035039
124MAPK110.30861059
125RPS6KA50.29626967
126BTK0.28929495
127PRKDC0.28913763
128NUAK10.28271502
129PTK60.22930932
130SIK30.21790094

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92021334
2Mismatch repair_Homo sapiens_hsa034304.33743847
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65884889
4Proteasome_Homo sapiens_hsa030503.35577740
5Base excision repair_Homo sapiens_hsa034103.18460893
6Spliceosome_Homo sapiens_hsa030403.14944574
7RNA transport_Homo sapiens_hsa030133.14504483
8One carbon pool by folate_Homo sapiens_hsa006703.03003466
9RNA polymerase_Homo sapiens_hsa030202.95724086
10Homologous recombination_Homo sapiens_hsa034402.91910826
11Ribosome_Homo sapiens_hsa030102.91803757
12Nucleotide excision repair_Homo sapiens_hsa034202.90933634
13* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76375533
14Cell cycle_Homo sapiens_hsa041102.73702996
15Pyrimidine metabolism_Homo sapiens_hsa002402.33716822
16Non-homologous end-joining_Homo sapiens_hsa034502.17083897
17Fanconi anemia pathway_Homo sapiens_hsa034602.07708990
18RNA degradation_Homo sapiens_hsa030181.97695371
19mRNA surveillance pathway_Homo sapiens_hsa030151.81502597
20Basal transcription factors_Homo sapiens_hsa030221.77339281
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64955201
22p53 signaling pathway_Homo sapiens_hsa041151.48980684
23Oxidative phosphorylation_Homo sapiens_hsa001901.31070378
24Purine metabolism_Homo sapiens_hsa002301.28158677
25Biosynthesis of amino acids_Homo sapiens_hsa012301.25839609
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18041031
27Epstein-Barr virus infection_Homo sapiens_hsa051691.16906779
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13997339
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10117890
30Selenocompound metabolism_Homo sapiens_hsa004500.99556830
31Systemic lupus erythematosus_Homo sapiens_hsa053220.97380094
32Viral carcinogenesis_Homo sapiens_hsa052030.96835042
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96428696
34Cysteine and methionine metabolism_Homo sapiens_hsa002700.94330981
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.94195653
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90264408
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86727169
38Oocyte meiosis_Homo sapiens_hsa041140.86426327
39Fatty acid elongation_Homo sapiens_hsa000620.85985231
40Carbon metabolism_Homo sapiens_hsa012000.85254176
41Antigen processing and presentation_Homo sapiens_hsa046120.82894307
42Pentose phosphate pathway_Homo sapiens_hsa000300.81835324
43Herpes simplex infection_Homo sapiens_hsa051680.81289227
44Thyroid cancer_Homo sapiens_hsa052160.81252415
45Protein export_Homo sapiens_hsa030600.80872831
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.80536957
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77629868
48HTLV-I infection_Homo sapiens_hsa051660.71961860
49Steroid biosynthesis_Homo sapiens_hsa001000.71594548
50Alzheimers disease_Homo sapiens_hsa050100.70040975
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69141692
52Propanoate metabolism_Homo sapiens_hsa006400.68539150
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65679456
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63920321
55Sulfur metabolism_Homo sapiens_hsa009200.62715415
56Legionellosis_Homo sapiens_hsa051340.62652481
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62147856
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59469215
59Fructose and mannose metabolism_Homo sapiens_hsa000510.57907682
60Folate biosynthesis_Homo sapiens_hsa007900.57523522
61Glutathione metabolism_Homo sapiens_hsa004800.56203411
62Huntingtons disease_Homo sapiens_hsa050160.55658490
63MicroRNAs in cancer_Homo sapiens_hsa052060.54329532
64N-Glycan biosynthesis_Homo sapiens_hsa005100.54167663
65Small cell lung cancer_Homo sapiens_hsa052220.53811603
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53619181
67Galactose metabolism_Homo sapiens_hsa000520.53520030
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52792708
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44804974
70Hippo signaling pathway_Homo sapiens_hsa043900.43115605
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.43059535
72Apoptosis_Homo sapiens_hsa042100.42162918
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41967158
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41661712
75Parkinsons disease_Homo sapiens_hsa050120.41410040
76Arginine biosynthesis_Homo sapiens_hsa002200.41235733
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40678001
78Vitamin B6 metabolism_Homo sapiens_hsa007500.39295621
79TGF-beta signaling pathway_Homo sapiens_hsa043500.38829453
80Fatty acid metabolism_Homo sapiens_hsa012120.37416548
81HIF-1 signaling pathway_Homo sapiens_hsa040660.36115720
82Measles_Homo sapiens_hsa051620.36057539
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35443057
84Basal cell carcinoma_Homo sapiens_hsa052170.32060004
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31656563
86Pancreatic cancer_Homo sapiens_hsa052120.31234687
87Vibrio cholerae infection_Homo sapiens_hsa051100.30801543
88Bladder cancer_Homo sapiens_hsa052190.30443172
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29724513
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29692655
91Sulfur relay system_Homo sapiens_hsa041220.29461068
92Colorectal cancer_Homo sapiens_hsa052100.29137566
93Chronic myeloid leukemia_Homo sapiens_hsa052200.27099490
94Hepatitis B_Homo sapiens_hsa051610.26394204
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25707376
96Alcoholism_Homo sapiens_hsa050340.25605895
97Viral myocarditis_Homo sapiens_hsa054160.24578919
98Influenza A_Homo sapiens_hsa051640.22687234
99Notch signaling pathway_Homo sapiens_hsa043300.22549031
100Lysine degradation_Homo sapiens_hsa003100.21091026
101Shigellosis_Homo sapiens_hsa051310.20712829
102Phenylalanine metabolism_Homo sapiens_hsa003600.20290569
103Acute myeloid leukemia_Homo sapiens_hsa052210.20193504
104Metabolic pathways_Homo sapiens_hsa011000.19439870
105Pathways in cancer_Homo sapiens_hsa052000.17610198
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17267884
107Primary immunodeficiency_Homo sapiens_hsa053400.16710583
108Adherens junction_Homo sapiens_hsa045200.15955930
109Melanoma_Homo sapiens_hsa052180.15847508
110Non-small cell lung cancer_Homo sapiens_hsa052230.15477746
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15083558
112Prostate cancer_Homo sapiens_hsa052150.14816500
113Hedgehog signaling pathway_Homo sapiens_hsa043400.14290990
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.13453088
115Cardiac muscle contraction_Homo sapiens_hsa042600.13107603
116Endometrial cancer_Homo sapiens_hsa052130.12408961
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.11235440
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10714083
119Pyruvate metabolism_Homo sapiens_hsa006200.10161047
120Arginine and proline metabolism_Homo sapiens_hsa003300.09334536

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