KARSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)7.44818588
2auditory behavior (GO:0031223)6.79475701
3mechanosensory behavior (GO:0007638)6.50098767
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.41231655
5negative regulation of B cell apoptotic process (GO:0002903)5.71878203
6vitamin transmembrane transport (GO:0035461)5.43240440
7positive regulation of interleukin-17 production (GO:0032740)5.17586597
8regulation of regulatory T cell differentiation (GO:0045589)4.94432980
9regulation of isotype switching to IgG isotypes (GO:0048302)4.82887606
10head development (GO:0060322)4.73988483
11regulation of immunoglobulin secretion (GO:0051023)4.72059759
12positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.52632172
13regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.52632172
14somite development (GO:0061053)4.50308765
15respiratory chain complex IV assembly (GO:0008535)4.34866320
16C4-dicarboxylate transport (GO:0015740)4.33672115
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.22798216
18response to auditory stimulus (GO:0010996)4.15742397
19L-fucose catabolic process (GO:0042355)4.05818689
20fucose catabolic process (GO:0019317)4.05818689
21L-fucose metabolic process (GO:0042354)4.05818689
22positive regulation of isotype switching (GO:0045830)3.87851951
23signal peptide processing (GO:0006465)3.79050433
24mitochondrial DNA replication (GO:0006264)3.61484874
25positive regulation of DNA recombination (GO:0045911)3.57569990
26cytochrome complex assembly (GO:0017004)3.51196837
27regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.48002679
28ear development (GO:0043583)3.44895761
29regulation of cofactor metabolic process (GO:0051193)3.42218560
30regulation of coenzyme metabolic process (GO:0051196)3.42218560
31ribosome biogenesis (GO:0042254)3.41956379
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26617287
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.26617287
34lung vasculature development (GO:0060426)3.23288249
35DNA damage response, detection of DNA damage (GO:0042769)3.20860691
36lung epithelium development (GO:0060428)3.18451556
37chaperone-mediated protein transport (GO:0072321)3.16578902
38regulation of acyl-CoA biosynthetic process (GO:0050812)3.14731984
39regulation of B cell apoptotic process (GO:0002902)3.09188048
40pseudouridine synthesis (GO:0001522)3.08389374
41L-serine metabolic process (GO:0006563)3.04270300
42nucleobase biosynthetic process (GO:0046112)2.99321599
43diaphragm development (GO:0060539)2.98497966
44pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.95378860
45UMP biosynthetic process (GO:0006222)2.95378860
46pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.95378860
47UMP metabolic process (GO:0046049)2.95378860
48protein complex biogenesis (GO:0070271)2.92999687
49behavioral response to nicotine (GO:0035095)2.91317287
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89329163
51regulation of sulfur metabolic process (GO:0042762)2.85325069
52mitochondrial respiratory chain complex assembly (GO:0033108)2.84876543
53tRNA aminoacylation (GO:0043039)2.84652639
54amino acid activation (GO:0043038)2.84652639
55tRNA aminoacylation for protein translation (GO:0006418)2.84479038
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84292931
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83182155
58GTP biosynthetic process (GO:0006183)2.82266861
59purine nucleobase biosynthetic process (GO:0009113)2.81886910
60epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.81437536
61otic vesicle formation (GO:0030916)2.80547527
62regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.79410512
63positive regulation of activated T cell proliferation (GO:0042104)2.76642838
64protein neddylation (GO:0045116)2.75481886
65postsynaptic membrane organization (GO:0001941)2.75238044
66maturation of SSU-rRNA (GO:0030490)2.74595703
67negative regulation of heart contraction (GO:0045822)2.73811294
68recombinational repair (GO:0000725)2.72438607
69branched-chain amino acid catabolic process (GO:0009083)2.71506027
70mannosylation (GO:0097502)2.70616253
71pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.68679168
72L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68583604
73peptidyl-arginine methylation (GO:0018216)2.67983114
74peptidyl-arginine N-methylation (GO:0035246)2.67983114
75NADH dehydrogenase complex assembly (GO:0010257)2.63905398
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.63905398
77mitochondrial respiratory chain complex I assembly (GO:0032981)2.63905398
78DNA deamination (GO:0045006)2.62929599
79positive regulation of JAK-STAT cascade (GO:0046427)2.62747206
80intracellular protein transmembrane import (GO:0044743)2.61078876
81tRNA processing (GO:0008033)2.60922217
82DNA replication checkpoint (GO:0000076)2.60220635
83DNA double-strand break processing (GO:0000729)2.59778479
84removal of superoxide radicals (GO:0019430)2.59675473
85cellular response to superoxide (GO:0071451)2.59675473
86cellular response to oxygen radical (GO:0071450)2.59675473
87double-strand break repair via homologous recombination (GO:0000724)2.59233859
88pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.57529129
89protein deneddylation (GO:0000338)2.56440281
90UTP metabolic process (GO:0046051)2.55590552
91positive regulation of dendritic spine development (GO:0060999)2.54606648
92preassembly of GPI anchor in ER membrane (GO:0016254)2.53828390
93regulation of interleukin-17 production (GO:0032660)2.53626983
94inositol phosphate catabolic process (GO:0071545)2.53200839
95attachment of spindle microtubules to kinetochore (GO:0008608)2.52848252
96response to pheromone (GO:0019236)2.51850280
97prenylation (GO:0097354)2.51690527
98protein prenylation (GO:0018342)2.51690527
99water-soluble vitamin biosynthetic process (GO:0042364)2.51127882
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50676377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.33934236
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89956249
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.40737016
4ZNF274_21170338_ChIP-Seq_K562_Hela3.35176127
5GBX2_23144817_ChIP-Seq_PC3_Human3.03486454
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81234061
7EZH2_22144423_ChIP-Seq_EOC_Human2.74487707
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.63453278
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48995122
10EWS_26573619_Chip-Seq_HEK293_Human2.41595469
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40784825
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36021771
13E2F7_22180533_ChIP-Seq_HELA_Human2.34961455
14VDR_22108803_ChIP-Seq_LS180_Human2.34715900
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31244636
16ELK1_19687146_ChIP-ChIP_HELA_Human2.31031201
17TAF15_26573619_Chip-Seq_HEK293_Human2.25384255
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.20783552
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18770989
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.10089334
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07085624
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02231412
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98162226
24VDR_23849224_ChIP-Seq_CD4+_Human1.94561444
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.90528143
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81668622
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.79662618
28FOXP3_21729870_ChIP-Seq_TREG_Human1.79448017
29MYC_18555785_ChIP-Seq_MESCs_Mouse1.77911284
30IRF1_19129219_ChIP-ChIP_H3396_Human1.73581360
31P300_19829295_ChIP-Seq_ESCs_Human1.69005424
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62675292
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61852735
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60804693
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60060542
36GATA1_22025678_ChIP-Seq_K562_Human1.56932146
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54804891
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49442860
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48251169
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46904438
41IGF1R_20145208_ChIP-Seq_DFB_Human1.43355398
42TP53_16413492_ChIP-PET_HCT116_Human1.38168189
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35126122
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34681442
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33752038
46FUS_26573619_Chip-Seq_HEK293_Human1.33078780
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30559072
48CBP_20019798_ChIP-Seq_JUKART_Human1.30559072
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30160612
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29605055
51MYC_18940864_ChIP-ChIP_HL60_Human1.29345933
52ER_23166858_ChIP-Seq_MCF-7_Human1.28967820
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28080184
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27398275
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26268757
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24683175
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23980809
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.21187324
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21176804
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20618096
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18544699
62MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17981378
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16878523
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16057920
65DCP1A_22483619_ChIP-Seq_HELA_Human1.15457915
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15143015
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13143138
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12016903
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10039880
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09953921
71AR_20517297_ChIP-Seq_VCAP_Human1.09947853
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07995665
73SOX2_19829295_ChIP-Seq_ESCs_Human1.06610744
74NANOG_19829295_ChIP-Seq_ESCs_Human1.06610744
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.05999179
76HTT_18923047_ChIP-ChIP_STHdh_Human1.03519853
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02411501
78BCAT_22108803_ChIP-Seq_LS180_Human1.02220304
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.01089109
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99975289
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99697347
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99297984
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98861265
84HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97754799
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.97234078
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97218225
87GABP_19822575_ChIP-Seq_HepG2_Human0.96206504
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94795190
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.94778913
90SMAD3_21741376_ChIP-Seq_EPCs_Human0.93773926
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93458755
92STAT3_23295773_ChIP-Seq_U87_Human0.92444464
93NCOR_22424771_ChIP-Seq_293T_Human0.90843687
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90783287
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.90588078
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90159535
97E2F1_21310950_ChIP-Seq_MCF-7_Human0.89970496
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89537560
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.89470141
100SMAD4_21799915_ChIP-Seq_A2780_Human0.88742999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.49666392
2MP0001853_heart_inflammation3.44038634
3MP0008789_abnormal_olfactory_epithelium3.23496426
4MP0008058_abnormal_DNA_repair3.18502867
5MP0000465_gastrointestinal_hemorrhage2.89253711
6MP0003300_gastrointestinal_ulcer2.86876886
7MP0005499_abnormal_olfactory_system2.73584494
8MP0005394_taste/olfaction_phenotype2.73584494
9MP0006072_abnormal_retinal_apoptosis2.62406161
10MP0001529_abnormal_vocalization2.55776482
11MP0002234_abnormal_pharynx_morphology2.51100775
12MP0004147_increased_porphyrin_level2.51081657
13MP0003646_muscle_fatigue2.45154283
14MP0008875_abnormal_xenobiotic_pharmacok2.36321732
15MP0002736_abnormal_nociception_after2.34453900
16MP0001293_anophthalmia2.34451700
17MP0008057_abnormal_DNA_replication2.16266254
18MP0010094_abnormal_chromosome_stability1.97321149
19MP0003186_abnormal_redox_activity1.96591186
20MP0000569_abnormal_digit_pigmentation1.87058403
21MP0002938_white_spotting1.86880884
22MP0003786_premature_aging1.84540535
23MP0000372_irregular_coat_pigmentation1.74864560
24MP0001984_abnormal_olfaction1.73367258
25MP0005670_abnormal_white_adipose1.73269137
26MP0005253_abnormal_eye_physiology1.72444039
27MP0000049_abnormal_middle_ear1.69362534
28MP0001835_abnormal_antigen_presentation1.66382831
29MP0001188_hyperpigmentation1.65944476
30MP0003122_maternal_imprinting1.62120153
31MP0001968_abnormal_touch/_nociception1.61891308
32MP0003718_maternal_effect1.60580709
33MP0000604_amyloidosis1.56382591
34MP0003937_abnormal_limbs/digits/tail_de1.54160316
35MP0005551_abnormal_eye_electrophysiolog1.47984207
36MP0005083_abnormal_biliary_tract1.45745907
37MP0004885_abnormal_endolymph1.43840180
38MP0002138_abnormal_hepatobiliary_system1.43697766
39MP0004145_abnormal_muscle_electrophysio1.40238477
40MP0009697_abnormal_copulation1.37079479
41MP0004957_abnormal_blastocyst_morpholog1.36785150
42MP0003121_genomic_imprinting1.36278170
43MP0003656_abnormal_erythrocyte_physiolo1.35647133
44MP0008877_abnormal_DNA_methylation1.35477575
45MP0003787_abnormal_imprinting1.32302046
46MP0001485_abnormal_pinna_reflex1.26595510
47MP0000631_abnormal_neuroendocrine_gland1.25543369
48MP0009384_cardiac_valve_regurgitation1.23599947
49MP0005187_abnormal_penis_morphology1.23481915
50MP0003567_abnormal_fetal_cardiomyocyte1.21436515
51MP0003195_calcinosis1.12618182
52MP0002233_abnormal_nose_morphology1.11104345
53MP0001661_extended_life_span1.09344628
54MP0008932_abnormal_embryonic_tissue1.08808636
55MP0002653_abnormal_ependyma_morphology1.05532833
56MP0000613_abnormal_salivary_gland1.02235313
57MP0005391_vision/eye_phenotype1.02208649
58MP0003136_yellow_coat_color0.95092470
59MP0002735_abnormal_chemical_nociception0.94837300
60MP0002177_abnormal_outer_ear0.92994985
61MP0003111_abnormal_nucleus_morphology0.91721833
62MP0008872_abnormal_physiological_respon0.89657084
63MP0001986_abnormal_taste_sensitivity0.88885846
64MP0003693_abnormal_embryo_hatching0.88443167
65MP0004142_abnormal_muscle_tone0.86868762
66MP0000647_abnormal_sebaceous_gland0.86542916
67MP0005266_abnormal_metabolism0.85092307
68MP0002405_respiratory_system_inflammati0.83346631
69MP0004782_abnormal_surfactant_physiolog0.81957615
70MP0002272_abnormal_nervous_system0.80585346
71MP0002090_abnormal_vision0.80134677
72MP0000678_abnormal_parathyroid_gland0.77075470
73MP0005410_abnormal_fertilization0.77022064
74MP0005671_abnormal_response_to0.76208365
75MP0006036_abnormal_mitochondrial_physio0.74977428
76MP0002163_abnormal_gland_morphology0.74178508
77MP0002876_abnormal_thyroid_physiology0.73636764
78MP0002160_abnormal_reproductive_system0.71813581
79MP0002102_abnormal_ear_morphology0.70803431
80MP0001286_abnormal_eye_development0.70370553
81MP0005332_abnormal_amino_acid0.66204083
82MP0003868_abnormal_feces_composition0.65750180
83MP0002127_abnormal_cardiovascular_syste0.64582867
84MP0004197_abnormal_fetal_growth/weight/0.62415506
85MP0005389_reproductive_system_phenotype0.61119269
86MP0004133_heterotaxia0.60590091
87MP0004924_abnormal_behavior0.58148571
88MP0005386_behavior/neurological_phenoty0.58148571
89MP0002638_abnormal_pupillary_reflex0.57431281
90MP0001764_abnormal_homeostasis0.56993438
91MP0005195_abnormal_posterior_eye0.56464567
92MP0003077_abnormal_cell_cycle0.56035413
93MP0002229_neurodegeneration0.55673611
94MP0001666_abnormal_nutrient_absorption0.55204626
95MP0003941_abnormal_skin_development0.54182096
96MP0010329_abnormal_lipoprotein_level0.53464381
97MP0002572_abnormal_emotion/affect_behav0.53300065
98MP0000026_abnormal_inner_ear0.51950216
99MP0006035_abnormal_mitochondrial_morpho0.51834530
100MP0010352_gastrointestinal_tract_polyps0.50830889

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the uterus (HP:0000013)5.13709334
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.01703865
3Bilateral microphthalmos (HP:0007633)4.73768170
4Chromsome breakage (HP:0040012)4.27330658
5Colon cancer (HP:0003003)4.26632623
6Ectopic kidney (HP:0000086)4.17434043
7Annular pancreas (HP:0001734)3.98480518
8Aplasia/hypoplasia of the uterus (HP:0008684)3.79299056
9Bile duct proliferation (HP:0001408)3.62762593
10Abnormal biliary tract physiology (HP:0012439)3.62762593
11Dyschromatopsia (HP:0007641)3.32492197
12Horseshoe kidney (HP:0000085)3.26653501
13Abnormality of alanine metabolism (HP:0010916)3.22264208
14Hyperalaninemia (HP:0003348)3.22264208
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.22264208
16Abnormal pancreas size (HP:0012094)3.20233336
17True hermaphroditism (HP:0010459)3.18010560
18Aplasia/Hypoplasia of the spleen (HP:0010451)3.08638000
19Small intestinal stenosis (HP:0012848)3.02926443
20Duodenal stenosis (HP:0100867)3.02926443
21Medulloblastoma (HP:0002885)3.01069723
22Abnormality of the aortic arch (HP:0012303)2.95998703
23Pancreatic fibrosis (HP:0100732)2.88672715
24Broad-based gait (HP:0002136)2.88070189
25Abnormal mitochondria in muscle tissue (HP:0008316)2.81281713
263-Methylglutaconic aciduria (HP:0003535)2.79410049
27Clubbing of toes (HP:0100760)2.70428183
28Abnormality of midbrain morphology (HP:0002418)2.69537520
29Molar tooth sign on MRI (HP:0002419)2.69537520
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.62901484
31Meckel diverticulum (HP:0002245)2.59565624
32Nephronophthisis (HP:0000090)2.55167530
33Abnormality of chromosome stability (HP:0003220)2.54176504
34Abnormality of the ileum (HP:0001549)2.53702407
35Abnormality of the duodenum (HP:0002246)2.50769994
36Anophthalmia (HP:0000528)2.48062560
37Acute necrotizing encephalopathy (HP:0006965)2.47397770
38Pancreatic cysts (HP:0001737)2.43825965
39Increased CSF lactate (HP:0002490)2.41059314
40Hepatocellular necrosis (HP:0001404)2.38024406
41Tubulointerstitial nephritis (HP:0001970)2.36986695
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29346085
43Abnormal lung lobation (HP:0002101)2.26447498
44Mitochondrial inheritance (HP:0001427)2.25313588
45Abnormality of serum amino acid levels (HP:0003112)2.21663957
46Hyperventilation (HP:0002883)2.20149182
47Duplicated collecting system (HP:0000081)2.19719295
48Glioma (HP:0009733)2.17673433
49Acute encephalopathy (HP:0006846)2.17632472
50Abnormality of the preputium (HP:0100587)2.14534380
51Abnormality of the renal medulla (HP:0100957)2.13681194
52Exercise-induced muscle cramps (HP:0003710)2.11544081
53Abnormality of glycine metabolism (HP:0010895)2.09820104
54Abnormality of serine family amino acid metabolism (HP:0010894)2.09820104
55Cerebral edema (HP:0002181)2.08679907
56Abnormality of the carotid arteries (HP:0005344)2.07500710
57Bicornuate uterus (HP:0000813)2.03327689
58Progressive macrocephaly (HP:0004481)2.02441723
59Pancytopenia (HP:0001876)2.01634187
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01352071
61Increased intramyocellular lipid droplets (HP:0012240)1.99545278
62Gonadotropin excess (HP:0000837)1.97866052
63Hepatic necrosis (HP:0002605)1.97658751
64Abnormality of methionine metabolism (HP:0010901)1.97170247
65Increased serum lactate (HP:0002151)1.97144857
66Ependymoma (HP:0002888)1.95662542
67Abnormality of the labia minora (HP:0012880)1.95300070
68Sloping forehead (HP:0000340)1.94046487
69Abnormality of the renal collecting system (HP:0004742)1.94038198
70Hyperglycinuria (HP:0003108)1.93780173
71Decreased muscle mass (HP:0003199)1.93588389
72Abolished electroretinogram (ERG) (HP:0000550)1.92348171
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91710766
74Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91710766
75Stenosis of the external auditory canal (HP:0000402)1.91529128
76Renal cortical cysts (HP:0000803)1.89112115
77Birth length less than 3rd percentile (HP:0003561)1.87999354
78Dry hair (HP:0011359)1.87633465
79Exercise intolerance (HP:0003546)1.86416905
80Chronic hepatic failure (HP:0100626)1.86115053
81Aplasia/Hypoplasia of the tibia (HP:0005772)1.86105871
82Lipid accumulation in hepatocytes (HP:0006561)1.83776982
83Stomatitis (HP:0010280)1.82522569
84Congenital stationary night blindness (HP:0007642)1.81945798
85Abnormality of the astrocytes (HP:0100707)1.81491993
86Astrocytoma (HP:0009592)1.81491993
87Truncus arteriosus (HP:0001660)1.78678069
88Chronic sinusitis (HP:0011109)1.78107804
89Intellectual disability, profound (HP:0002187)1.76663203
90Constricted visual fields (HP:0001133)1.74121113
91Abnormality of pyrimidine metabolism (HP:0004353)1.71225068
92Increased hepatocellular lipid droplets (HP:0006565)1.71138791
93Microvesicular hepatic steatosis (HP:0001414)1.70720758
94Increased muscle lipid content (HP:0009058)1.70646929
95Congenital hepatic fibrosis (HP:0002612)1.70209220
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.69984245
97Oligohydramnios (HP:0001562)1.69816473
98Confusion (HP:0001289)1.68231982
99Basal cell carcinoma (HP:0002671)1.68229550
100Respiratory failure (HP:0002878)1.68223145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.78566393
2NEK13.20883638
3TNIK3.20607526
4BMPR1B3.02573078
5MST42.91042343
6NUAK12.90053643
7MAP4K22.85587745
8ACVR1B2.73998318
9FRK2.59006261
10TRIM282.56645025
11PDK22.56491299
12AKT32.35632916
13NLK2.21909555
14GRK12.13772334
15CDC72.11129425
16NME12.02326173
17BCKDK1.96222776
18BUB11.84648498
19MKNK21.77252696
20ZAK1.75418817
21CASK1.71714118
22EPHA31.68339916
23TXK1.63419010
24TSSK61.54406981
25PLK41.47764616
26PBK1.45766717
27VRK21.40823751
28CSNK1A1L1.38269227
29TAF11.36128464
30FLT31.33993201
31MAPK131.26773964
32VRK11.25610068
33BRD41.25552635
34MKNK11.22988546
35PLK31.18469198
36ATR1.16807535
37TEC1.15994348
38EIF2AK31.11883844
39PAK41.05968009
40CSNK1G11.03382751
41STK38L1.02287914
42MAP3K41.01739237
43PINK11.01436533
44CSNK1G20.89370220
45OBSCN0.87975949
46DYRK20.86625450
47MUSK0.85460824
48WEE10.84092341
49PIK3CG0.84035658
50CSNK1G30.81138012
51STK160.80191196
52NEK90.79435386
53PLK10.78050117
54SGK20.77555194
55ADRBK20.73545970
56EIF2AK10.70386145
57CSNK1A10.68244994
58DYRK30.66502641
59PLK20.64934637
60RPS6KA50.63746223
61PIK3CA0.61265652
62TTK0.55478298
63ATM0.53408397
64DYRK1A0.52730487
65CCNB10.52060732
66INSRR0.49888481
67ALK0.49187133
68PIM10.48947159
69PRKCE0.46499537
70CDK90.46470029
71CHEK10.45475177
72TGFBR10.43234816
73CAMK1D0.41859138
74CDK30.37317911
75PNCK0.36996680
76PRKDC0.36684207
77CHEK20.36574844
78SGK30.35969091
79MAP2K70.35928025
80SGK2230.35558818
81SGK4940.35558818
82CSNK2A10.34136365
83EIF2AK20.34073977
84RAF10.33859127
85BRSK20.31589635
86CDK70.30650940
87AURKB0.30599788
88MAP3K120.29913801
89PRKCG0.29682144
90CSNK2A20.28192266
91CAMK2A0.25704800
92IRAK10.23702708
93PRKACA0.23508426
94CDK10.22961518
95CSNK1E0.22402919
96CAMK10.21801109
97RPS6KA30.20738544
98PRKCQ0.19646924
99CAMKK20.19569763
100CAMK1G0.18785758

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.81314762
2Proteasome_Homo sapiens_hsa030503.82743957
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69852381
4Non-homologous end-joining_Homo sapiens_hsa034502.60637911
5Fanconi anemia pathway_Homo sapiens_hsa034602.54009402
6Protein export_Homo sapiens_hsa030602.38483468
7Basal transcription factors_Homo sapiens_hsa030222.37522413
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36856929
9Homologous recombination_Homo sapiens_hsa034402.29055542
10RNA polymerase_Homo sapiens_hsa030202.28556875
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20815422
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10206025
13DNA replication_Homo sapiens_hsa030302.08762796
14Mismatch repair_Homo sapiens_hsa034302.04970788
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03122710
16RNA degradation_Homo sapiens_hsa030181.83079551
17Propanoate metabolism_Homo sapiens_hsa006401.72962967
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.62168176
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57192395
20Pyrimidine metabolism_Homo sapiens_hsa002401.53304695
21Steroid biosynthesis_Homo sapiens_hsa001001.50501699
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48806239
23Peroxisome_Homo sapiens_hsa041461.44499749
24Nucleotide excision repair_Homo sapiens_hsa034201.44343102
25Asthma_Homo sapiens_hsa053101.42072296
26Vitamin B6 metabolism_Homo sapiens_hsa007501.37504861
27Selenocompound metabolism_Homo sapiens_hsa004501.33421066
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33346896
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.32202766
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.29363697
31Biosynthesis of amino acids_Homo sapiens_hsa012301.28961876
32Oxidative phosphorylation_Homo sapiens_hsa001901.28565232
33One carbon pool by folate_Homo sapiens_hsa006701.26282454
34RNA transport_Homo sapiens_hsa030131.26131872
35Pyruvate metabolism_Homo sapiens_hsa006201.23939517
36Allograft rejection_Homo sapiens_hsa053301.23597205
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17041741
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14704795
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14534684
40Graft-versus-host disease_Homo sapiens_hsa053321.14090504
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.09735227
42Parkinsons disease_Homo sapiens_hsa050121.07130444
43Type I diabetes mellitus_Homo sapiens_hsa049401.05453952
44Arginine and proline metabolism_Homo sapiens_hsa003301.05364901
45Lysine degradation_Homo sapiens_hsa003101.04938744
46Autoimmune thyroid disease_Homo sapiens_hsa053201.03762850
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02567503
48Carbon metabolism_Homo sapiens_hsa012001.02370687
49Nitrogen metabolism_Homo sapiens_hsa009100.99152727
50Base excision repair_Homo sapiens_hsa034100.96099981
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94829134
52Regulation of autophagy_Homo sapiens_hsa041400.94702146
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91358157
54Huntingtons disease_Homo sapiens_hsa050160.90851463
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89928578
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88896260
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86150764
58beta-Alanine metabolism_Homo sapiens_hsa004100.86085821
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.84649507
60Butanoate metabolism_Homo sapiens_hsa006500.84617245
61Purine metabolism_Homo sapiens_hsa002300.84202519
62Spliceosome_Homo sapiens_hsa030400.83423964
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80050647
64Ribosome_Homo sapiens_hsa030100.79534356
65Glutathione metabolism_Homo sapiens_hsa004800.78055934
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77248233
67Folate biosynthesis_Homo sapiens_hsa007900.73239608
68Tryptophan metabolism_Homo sapiens_hsa003800.71722847
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71007690
70Primary immunodeficiency_Homo sapiens_hsa053400.70254812
71Retinol metabolism_Homo sapiens_hsa008300.70034800
72Phototransduction_Homo sapiens_hsa047440.67175478
73Metabolic pathways_Homo sapiens_hsa011000.66621728
74Chemical carcinogenesis_Homo sapiens_hsa052040.64980525
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62708797
76Alzheimers disease_Homo sapiens_hsa050100.54894271
77Olfactory transduction_Homo sapiens_hsa047400.52874026
78Fatty acid degradation_Homo sapiens_hsa000710.52336753
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51372554
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51157662
81Fatty acid elongation_Homo sapiens_hsa000620.49160415
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48751157
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46619049
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.44376740
85TGF-beta signaling pathway_Homo sapiens_hsa043500.41734577
86Fatty acid metabolism_Homo sapiens_hsa012120.40723754
87Mineral absorption_Homo sapiens_hsa049780.40509807
88Basal cell carcinoma_Homo sapiens_hsa052170.38557032
89Systemic lupus erythematosus_Homo sapiens_hsa053220.38448198
90Vitamin digestion and absorption_Homo sapiens_hsa049770.37186100
91Insulin secretion_Homo sapiens_hsa049110.36502020
92Taste transduction_Homo sapiens_hsa047420.34238456
93ABC transporters_Homo sapiens_hsa020100.32145661
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31373229
95Fatty acid biosynthesis_Homo sapiens_hsa000610.30512447
96Cell cycle_Homo sapiens_hsa041100.26923408
97Fructose and mannose metabolism_Homo sapiens_hsa000510.26324548
98Cardiac muscle contraction_Homo sapiens_hsa042600.24963372
99Hematopoietic cell lineage_Homo sapiens_hsa046400.24339205
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23551205

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