KARSP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.81369377
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.01839264
3regulation of memory T cell differentiation (GO:0043380)4.92773790
4behavioral response to nicotine (GO:0035095)4.62345904
5platelet dense granule organization (GO:0060155)4.61969757
6cytidine deamination (GO:0009972)4.50221687
7cytidine metabolic process (GO:0046087)4.50221687
8cytidine catabolic process (GO:0006216)4.50221687
9negative regulation of thymocyte apoptotic process (GO:0070244)4.37076598
10positive regulation of defense response to virus by host (GO:0002230)4.36073511
11positive regulation of interleukin-17 production (GO:0032740)4.28192562
12pyrimidine ribonucleoside catabolic process (GO:0046133)3.84415164
13tachykinin receptor signaling pathway (GO:0007217)3.80142202
14positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.79154401
15response to pheromone (GO:0019236)3.74389570
16regulation of regulatory T cell differentiation (GO:0045589)3.71041515
17L-fucose catabolic process (GO:0042355)3.57425387
18fucose catabolic process (GO:0019317)3.57425387
19L-fucose metabolic process (GO:0042354)3.57425387
20regulation of cilium movement (GO:0003352)3.52950440
21detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43478340
22negative regulation of B cell apoptotic process (GO:0002903)3.31726899
23inositol phosphate dephosphorylation (GO:0046855)3.29925573
24phosphorylated carbohydrate dephosphorylation (GO:0046838)3.29925573
25inositol phosphate catabolic process (GO:0071545)3.23911107
26regulation of thymocyte apoptotic process (GO:0070243)3.21327328
27regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.12424926
28piRNA metabolic process (GO:0034587)3.10244135
29respiratory chain complex IV assembly (GO:0008535)3.09131562
30regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.06216259
31aggressive behavior (GO:0002118)3.02922050
32regulation of action potential (GO:0098900)3.01943359
33adaptation of signaling pathway (GO:0023058)3.00164487
34negative regulation by host of viral transcription (GO:0043922)2.99119691
35cytochrome complex assembly (GO:0017004)2.97263074
36regulation of isotype switching to IgG isotypes (GO:0048302)2.95672963
37regulation of T cell mediated cytotoxicity (GO:0001914)2.95638320
38regulation of B cell apoptotic process (GO:0002902)2.91853490
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90555797
40positive regulation of T-helper 1 type immune response (GO:0002827)2.89458161
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86993752
42auditory receptor cell stereocilium organization (GO:0060088)2.86669970
43rRNA catabolic process (GO:0016075)2.82917002
44detection of light stimulus involved in sensory perception (GO:0050962)2.82619448
45detection of light stimulus involved in visual perception (GO:0050908)2.82619448
46signal peptide processing (GO:0006465)2.80679313
47regulation of defense response to virus by host (GO:0050691)2.77270328
48dopamine transport (GO:0015872)2.75460971
49reflex (GO:0060004)2.73513696
50positive regulation of uterine smooth muscle contraction (GO:0070474)2.71497431
51positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70339747
52polyol catabolic process (GO:0046174)2.70032521
53S-adenosylmethionine metabolic process (GO:0046500)2.69107686
54water-soluble vitamin biosynthetic process (GO:0042364)2.68126366
55purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.67657164
56protein complex biogenesis (GO:0070271)2.66294983
57regulation of chronic inflammatory response (GO:0002676)2.60927809
58resolution of meiotic recombination intermediates (GO:0000712)2.58730281
59axoneme assembly (GO:0035082)2.56765709
60mast cell activation involved in immune response (GO:0002279)2.56304075
61mast cell degranulation (GO:0043303)2.56304075
62negative regulation of lymphocyte apoptotic process (GO:0070229)2.55916893
63regulation of germinal center formation (GO:0002634)2.55807637
64regulation of activation of Janus kinase activity (GO:0010533)2.55405995
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54022278
66protein-cofactor linkage (GO:0018065)2.53493459
67activated T cell proliferation (GO:0050798)2.52785290
68reciprocal meiotic recombination (GO:0007131)2.52213710
69reciprocal DNA recombination (GO:0035825)2.52213710
70positive regulation of fatty acid transport (GO:2000193)2.51450332
71regulation of hexokinase activity (GO:1903299)2.48783095
72regulation of glucokinase activity (GO:0033131)2.48783095
73regulation of microtubule-based movement (GO:0060632)2.47224229
74cellular response to ethanol (GO:0071361)2.45874449
75regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.45545602
76nonmotile primary cilium assembly (GO:0035058)2.45483782
77multicellular organism reproduction (GO:0032504)2.43997716
78cellular ketone body metabolic process (GO:0046950)2.43507964
79GPI anchor metabolic process (GO:0006505)2.42628050
80recombinational repair (GO:0000725)2.42199756
81positive regulation of cell fate commitment (GO:0010455)2.42037908
82positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.41894678
83double-strand break repair via homologous recombination (GO:0000724)2.40282565
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40193651
85regulation of interleukin-17 production (GO:0032660)2.38741290
86negative regulation of appetite (GO:0032099)2.38718357
87negative regulation of response to food (GO:0032096)2.38718357
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.37649006
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.37649006
90positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.35468688
91T cell differentiation (GO:0030217)2.35379901
92regulation of immunoglobulin secretion (GO:0051023)2.35214496
93cytokine biosynthetic process (GO:0042089)2.34602987
94DNA double-strand break processing (GO:0000729)2.34053527
95neuronal action potential propagation (GO:0019227)2.33399472
96negative regulation of T cell apoptotic process (GO:0070233)2.33051959
97positive regulation of protein homooligomerization (GO:0032464)2.32775061
98protein K6-linked ubiquitination (GO:0085020)2.32054197
99gamma-aminobutyric acid transport (GO:0015812)2.31120363
100DNA methylation involved in gamete generation (GO:0043046)2.30227261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.39577570
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.05170703
3ZNF274_21170338_ChIP-Seq_K562_Hela2.97370605
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59978006
5IGF1R_20145208_ChIP-Seq_DFB_Human2.48602976
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.47920589
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.47392403
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31397658
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29983792
10GBX2_23144817_ChIP-Seq_PC3_Human2.19539357
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17848053
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.16414136
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.02613811
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.00472707
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.98861714
16EWS_26573619_Chip-Seq_HEK293_Human1.97766087
17P300_19829295_ChIP-Seq_ESCs_Human1.93055477
18ER_23166858_ChIP-Seq_MCF-7_Human1.90712040
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89865779
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82765264
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77459080
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76406372
23TP53_22573176_ChIP-Seq_HFKS_Human1.66589007
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66128329
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63750658
26FUS_26573619_Chip-Seq_HEK293_Human1.63083222
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61831949
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61444597
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60096362
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60041330
31TAF15_26573619_Chip-Seq_HEK293_Human1.59936260
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59796470
33SOX2_19829295_ChIP-Seq_ESCs_Human1.59689846
34NANOG_19829295_ChIP-Seq_ESCs_Human1.59689846
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56022746
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53407206
37BCAT_22108803_ChIP-Seq_LS180_Human1.53080446
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51739204
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51015128
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.50422178
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49105744
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48296994
43CBP_20019798_ChIP-Seq_JUKART_Human1.48296994
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.45689790
45VDR_23849224_ChIP-Seq_CD4+_Human1.43042874
46GATA3_26560356_Chip-Seq_TH2_Human1.42048721
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.40826591
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39679721
49TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.37946804
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37880147
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.35617210
52TCF4_23295773_ChIP-Seq_U87_Human1.33643417
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33544199
54ELK1_19687146_ChIP-ChIP_HELA_Human1.32775527
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30719349
56IRF1_19129219_ChIP-ChIP_H3396_Human1.30044613
57MYC_18940864_ChIP-ChIP_HL60_Human1.29683156
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.29661690
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.29327318
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29327318
61SMAD4_21799915_ChIP-Seq_A2780_Human1.28879158
62STAT3_23295773_ChIP-Seq_U87_Human1.28804243
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28718028
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.27213043
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26036266
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25420223
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.24761658
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24311952
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23235274
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.22736383
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21504694
72AR_25329375_ChIP-Seq_VCAP_Human1.20877745
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20594790
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20593004
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.19497778
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19312351
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.18501652
78AR_20517297_ChIP-Seq_VCAP_Human1.18129798
79P53_22387025_ChIP-Seq_ESCs_Mouse1.17564039
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17458055
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16133031
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.15663634
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15573136
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.15423747
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13766800
86NCOR_22424771_ChIP-Seq_293T_Human1.13051968
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.12994589
88RUNX2_22187159_ChIP-Seq_PCA_Human1.12420169
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11457527
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.11446801
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10890589
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.09173830
93SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08969178
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08805269
95TCF4_22108803_ChIP-Seq_LS180_Human1.08477099
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.08091434
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.07319739
98GATA3_27048872_Chip-Seq_THYMUS_Human1.07034514
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.06610118
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06439270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology3.48859570
2MP0005671_abnormal_response_to3.12937123
3MP0000372_irregular_coat_pigmentation2.92680905
4MP0001835_abnormal_antigen_presentation2.78469403
5MP0002166_altered_tumor_susceptibility2.41035875
6MP0008872_abnormal_physiological_respon2.40083013
7MP0001968_abnormal_touch/_nociception2.34263399
8MP0005645_abnormal_hypothalamus_physiol2.15975802
9MP0009785_altered_susceptibility_to2.05024039
10MP0002102_abnormal_ear_morphology2.03631645
11MP0002132_abnormal_respiratory_system2.02639133
12MP0002736_abnormal_nociception_after1.97212964
13MP0003195_calcinosis1.92737330
14MP0003646_muscle_fatigue1.91419039
15MP0001986_abnormal_taste_sensitivity1.90659608
16MP0005551_abnormal_eye_electrophysiolog1.89961520
17MP0008877_abnormal_DNA_methylation1.87955918
18MP0004147_increased_porphyrin_level1.86652600
19MP0001984_abnormal_olfaction1.83594685
20MP0005387_immune_system_phenotype1.79409615
21MP0001790_abnormal_immune_system1.79409615
22MP0003011_delayed_dark_adaptation1.78701226
23MP0001501_abnormal_sleep_pattern1.73168863
24MP0002006_tumorigenesis1.70228827
25MP0000685_abnormal_immune_system1.69866637
26MP0002148_abnormal_hypersensitivity_rea1.69462719
27MP0000013_abnormal_adipose_tissue1.68495875
28MP0008875_abnormal_xenobiotic_pharmacok1.68214215
29MP0002933_joint_inflammation1.66455211
30MP0001800_abnormal_humoral_immune1.64317687
31MP0005253_abnormal_eye_physiology1.61950041
32MP0002277_abnormal_respiratory_mucosa1.54605507
33MP0003763_abnormal_thymus_physiology1.53402440
34MP0005167_abnormal_blood-brain_barrier1.45238192
35MP0005075_abnormal_melanosome_morpholog1.43990502
36MP0002837_dystrophic_cardiac_calcinosis1.41334973
37MP0000569_abnormal_digit_pigmentation1.40761047
38MP0006292_abnormal_olfactory_placode1.39358350
39MP0005174_abnormal_tail_pigmentation1.36693687
40MP0006072_abnormal_retinal_apoptosis1.36637354
41MP0009764_decreased_sensitivity_to1.35559283
42MP0004043_abnormal_pH_regulation1.34399382
43MP0005646_abnormal_pituitary_gland1.33589557
44MP0003724_increased_susceptibility_to1.33535711
45MP0005000_abnormal_immune_tolerance1.32987069
46MP0010386_abnormal_urinary_bladder1.32557824
47MP0003787_abnormal_imprinting1.32001501
48MP0009745_abnormal_behavioral_response1.31351985
49MP0010155_abnormal_intestine_physiology1.28558073
50MP0004885_abnormal_endolymph1.26320326
51MP0005389_reproductive_system_phenotype1.26190895
52MP0008775_abnormal_heart_ventricle1.23736834
53MP0000427_abnormal_hair_cycle1.21745255
54MP0004145_abnormal_muscle_electrophysio1.17375406
55MP0002723_abnormal_immune_serum1.17347715
56MP0002272_abnormal_nervous_system1.16417533
57MP0004142_abnormal_muscle_tone1.15202560
58MP0005410_abnormal_fertilization1.15132408
59MP0002234_abnormal_pharynx_morphology1.12801829
60MP0002938_white_spotting1.12675434
61MP0002693_abnormal_pancreas_physiology1.11687820
62MP0002420_abnormal_adaptive_immunity1.11670627
63MP0001529_abnormal_vocalization1.11039991
64MP0005084_abnormal_gallbladder_morpholo1.10916509
65MP0002095_abnormal_skin_pigmentation1.08593391
66MP0001819_abnormal_immune_cell1.08358572
67MP0003252_abnormal_bile_duct1.06179375
68MP0001919_abnormal_reproductive_system1.03662436
69MP0001764_abnormal_homeostasis1.03161785
70MP0000465_gastrointestinal_hemorrhage1.01306151
71MP0002160_abnormal_reproductive_system0.99993814
72MP0002452_abnormal_antigen_presenting0.96787448
73MP0001486_abnormal_startle_reflex0.94286497
74MP0010329_abnormal_lipoprotein_level0.90963931
75MP0002735_abnormal_chemical_nociception0.90514591
76MP0002138_abnormal_hepatobiliary_system0.90023078
77MP0009046_muscle_twitch0.89933238
78MP0005386_behavior/neurological_phenoty0.89263917
79MP0004924_abnormal_behavior0.89263917
80MP0002733_abnormal_thermal_nociception0.88363051
81MP0002163_abnormal_gland_morphology0.88112198
82MP0004084_abnormal_cardiac_muscle0.87159507
83MP0009697_abnormal_copulation0.86791963
84MP0000230_abnormal_systemic_arterial0.86577889
85MP0002572_abnormal_emotion/affect_behav0.86498556
86MP0003718_maternal_effect0.85404788
87MP0005379_endocrine/exocrine_gland_phen0.85084932
88MP0000689_abnormal_spleen_morphology0.84931860
89MP0002398_abnormal_bone_marrow0.84416276
90MP0004133_heterotaxia0.84311292
91MP0005085_abnormal_gallbladder_physiolo0.83476189
92MP0002638_abnormal_pupillary_reflex0.81962951
93MP0003567_abnormal_fetal_cardiomyocyte0.81456116
94MP0005025_abnormal_response_to0.80168279
95MP0002405_respiratory_system_inflammati0.80031607
96MP0005310_abnormal_salivary_gland0.79927839
97MP0001879_abnormal_lymphatic_vessel0.79709796
98MP0000015_abnormal_ear_pigmentation0.79130895
99MP0005365_abnormal_bile_salt0.78732377
100MP0006082_CNS_inflammation0.77232076

Predicted human phenotypes

RankGene SetZ-score
1Thyroiditis (HP:0100646)5.61123462
2B lymphocytopenia (HP:0010976)5.49351635
3Abnormality of B cell number (HP:0010975)5.35194989
4Severe combined immunodeficiency (HP:0004430)5.22233879
5Panhypogammaglobulinemia (HP:0003139)5.00774290
6Hypoproteinemia (HP:0003075)4.91764107
7T lymphocytopenia (HP:0005403)4.36303827
8Abnormality of T cell number (HP:0011839)4.08139422
9Hypoplasia of the thymus (HP:0000778)4.01542506
10Combined immunodeficiency (HP:0005387)3.99504071
11IgG deficiency (HP:0004315)3.91860059
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42612078
13Congenital stationary night blindness (HP:0007642)3.40255405
14Abnormal rod and cone electroretinograms (HP:0008323)3.26004740
15Eosinophilia (HP:0001880)3.25173619
16Abnormality of eosinophils (HP:0001879)3.11927065
173-Methylglutaconic aciduria (HP:0003535)3.11651446
18Hypoplasia of the pons (HP:0012110)3.01083276
19Abnormality of the pons (HP:0007361)2.99899004
20Type II lissencephaly (HP:0007260)2.90235125
21Abnormality of T cells (HP:0002843)2.89683042
22Abolished electroretinogram (ERG) (HP:0000550)2.87598508
23Pancreatic cysts (HP:0001737)2.82896961
24Attenuation of retinal blood vessels (HP:0007843)2.79014242
25Erythroderma (HP:0001019)2.78215713
26Molar tooth sign on MRI (HP:0002419)2.74918279
27Abnormality of midbrain morphology (HP:0002418)2.74918279
28Methylmalonic aciduria (HP:0012120)2.70186987
29Stomatitis (HP:0010280)2.68838611
30Increased hepatocellular lipid droplets (HP:0006565)2.64559111
31Pendular nystagmus (HP:0012043)2.61903539
32Hyperventilation (HP:0002883)2.59182855
33Decreased central vision (HP:0007663)2.56901602
34Abnormality of the renal cortex (HP:0011035)2.51504719
35Pancreatic fibrosis (HP:0100732)2.51330923
36Increased corneal curvature (HP:0100692)2.49720668
37Keratoconus (HP:0000563)2.49720668
38Lipid accumulation in hepatocytes (HP:0006561)2.47768303
39Gaze-evoked nystagmus (HP:0000640)2.38264323
40Medial flaring of the eyebrow (HP:0010747)2.37104411
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.35908128
42Granulocytopenia (HP:0001913)2.23317616
43Renal cortical cysts (HP:0000803)2.15058047
44Large for gestational age (HP:0001520)2.14885064
45Recurrent cutaneous fungal infections (HP:0011370)2.12415376
46Chronic mucocutaneous candidiasis (HP:0002728)2.12415376
47Recurrent fungal infections (HP:0002841)2.11033377
48True hermaphroditism (HP:0010459)2.09905377
49Mitochondrial inheritance (HP:0001427)2.09793525
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09199757
51Hypothermia (HP:0002045)2.07718594
52Abnormality of the renal medulla (HP:0100957)2.06749208
53Methylmalonic acidemia (HP:0002912)2.05876325
54Progressive macrocephaly (HP:0004481)2.04554723
55Recurrent viral infections (HP:0004429)2.03054656
56Elevated erythrocyte sedimentation rate (HP:0003565)2.02358981
57Encephalitis (HP:0002383)2.01622299
58Optic neuritis (HP:0100653)2.01113073
59Retrobulbar optic neuritis (HP:0100654)2.01113073
60Abnormality of T cell physiology (HP:0011840)2.00807095
61Nephronophthisis (HP:0000090)2.00236079
62Prostate neoplasm (HP:0100787)1.97394803
63Stomach cancer (HP:0012126)1.97375476
64Agammaglobulinemia (HP:0004432)1.94034979
65Fair hair (HP:0002286)1.94004513
66Chronic hepatic failure (HP:0100626)1.93640154
67Acute necrotizing encephalopathy (HP:0006965)1.92954251
68Renal Fanconi syndrome (HP:0001994)1.92352043
69Increased CSF lactate (HP:0002490)1.90951860
70Leukocytosis (HP:0001974)1.90457901
71Bile duct proliferation (HP:0001408)1.87631969
72Abnormal biliary tract physiology (HP:0012439)1.87631969
73Abnormal albumin level (HP:0012116)1.86513502
74Hypoalbuminemia (HP:0003073)1.86513502
75Increased intramyocellular lipid droplets (HP:0012240)1.85889802
76Meningitis (HP:0001287)1.83797379
77Abnormality of alanine metabolism (HP:0010916)1.83218672
78Hyperalaninemia (HP:0003348)1.83218672
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83218672
80Constricted visual fields (HP:0001133)1.83070252
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82421097
82Abnormality of the prostate (HP:0008775)1.81447888
83Intestinal atresia (HP:0011100)1.80725541
84Hypomagnesemia (HP:0002917)1.80411990
85Broad-based gait (HP:0002136)1.80308580
86Hematochezia (HP:0002573)1.79973079
87Acute encephalopathy (HP:0006846)1.79691880
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77183887
89Dicarboxylic aciduria (HP:0003215)1.77183887
90Metabolic alkalosis (HP:0200114)1.75326554
91Aplasia/Hypoplasia of the fovea (HP:0008060)1.74825750
92Hypoplasia of the fovea (HP:0007750)1.74825750
93Severe visual impairment (HP:0001141)1.73955864
94Autoimmune hemolytic anemia (HP:0001890)1.73445272
95Chronic sinusitis (HP:0011109)1.73254393
96Gait imbalance (HP:0002141)1.70492442
97Exertional dyspnea (HP:0002875)1.68917850
98Ketoacidosis (HP:0001993)1.68444672
99Ketosis (HP:0001946)1.67475088
100Metaphyseal dysplasia (HP:0100255)1.67144414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.38914923
2TXK3.00161588
3ADRBK22.95750111
4NUAK12.72769183
5MAP4K22.69906201
6VRK22.67955837
7EIF2AK32.52996995
8TAF12.47289526
9GRK12.17332127
10WNK32.07598964
11MST42.04986868
12TAOK31.88413417
13FES1.82707092
14BMPR1B1.74049455
15PINK11.68433698
16INSRR1.67871791
17TIE11.65671447
18ZAK1.60524595
19ACVR1B1.60261585
20WNK41.59294603
21TLK11.58345592
22MAP3K121.54776562
23MAPK131.48803679
24VRK11.46056463
25KDR1.42497067
26RIPK41.41205944
27NLK1.40560005
28CAMKK21.29536889
29TEC1.26345797
30OXSR11.13250287
31EIF2AK21.04976964
32ITK1.01047054
33BMPR21.00533797
34GRK50.98911668
35DYRK20.95605388
36IKBKE0.93722666
37IKBKB0.91478617
38PHKG20.91251523
39PHKG10.91251523
40NTRK30.88630792
41BRSK20.86481649
42TNIK0.85676961
43ADRBK10.82809181
44KIT0.81515777
45PRKCQ0.80154906
46CLK10.79712156
47CSNK1G10.77977325
48PLK30.77617455
49MAP3K40.76878280
50PRKCE0.75436689
51CSF1R0.72169843
52GRK70.70953717
53DAPK10.69824110
54TNK20.68421653
55STK110.66930060
56PIK3CA0.65783492
57PRKCG0.62396434
58HIPK20.59175047
59LYN0.58721664
60DAPK20.57287370
61STK390.56314432
62SYK0.55499962
63ERBB30.55082504
64PIK3CG0.55073482
65HCK0.54695872
66MAP3K110.53909736
67CHUK0.52730708
68STK30.49090466
69DYRK1A0.47193509
70CSNK1G20.46684250
71MKNK20.45962995
72CSNK1G30.44074606
73FGFR20.43848470
74TRPM70.43831032
75STK40.42459813
76GSK3A0.41900570
77WEE10.41867200
78MARK30.41507628
79MAP3K140.41441352
80MAPK110.40741050
81BCKDK0.40660222
82RPS6KA50.40294454
83MAPKAPK50.39681576
84PRKAA20.39424834
85PLK20.39304283
86MUSK0.39161650
87MELK0.38633915
88IGF1R0.38351447
89ABL10.38083035
90CSNK1A1L0.37980334
91PAK30.37079260
92CAMK2A0.36786213
93STK38L0.36630463
94TGFBR10.36585255
95LCK0.36531482
96PTK2B0.35700144
97CAMK10.35137514
98TBK10.33420912
99TRIM280.33075571
100CSNK1A10.31905285

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.86472302
2Proteasome_Homo sapiens_hsa030502.78375039
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.51008919
4Type I diabetes mellitus_Homo sapiens_hsa049402.48732892
5Allograft rejection_Homo sapiens_hsa053302.43826735
6Asthma_Homo sapiens_hsa053102.40217448
7Graft-versus-host disease_Homo sapiens_hsa053322.40203835
8Homologous recombination_Homo sapiens_hsa034402.38092964
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37371403
10Autoimmune thyroid disease_Homo sapiens_hsa053202.29343167
11Phototransduction_Homo sapiens_hsa047442.20218637
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.19756001
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19128736
14Non-homologous end-joining_Homo sapiens_hsa034502.12958173
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01509836
16Linoleic acid metabolism_Homo sapiens_hsa005911.84411305
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83995420
18Oxidative phosphorylation_Homo sapiens_hsa001901.81776563
19Protein export_Homo sapiens_hsa030601.74195902
20Hematopoietic cell lineage_Homo sapiens_hsa046401.72559243
21Caffeine metabolism_Homo sapiens_hsa002321.71131157
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62183648
23Propanoate metabolism_Homo sapiens_hsa006401.60155409
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58664547
25Nitrogen metabolism_Homo sapiens_hsa009101.57719219
26Butanoate metabolism_Homo sapiens_hsa006501.53412174
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52094953
28Basal transcription factors_Homo sapiens_hsa030221.49157179
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48840963
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45993508
31Rheumatoid arthritis_Homo sapiens_hsa053231.45887243
32RNA degradation_Homo sapiens_hsa030181.45532031
33Antigen processing and presentation_Homo sapiens_hsa046121.37548073
34Nicotine addiction_Homo sapiens_hsa050331.36192014
35Fanconi anemia pathway_Homo sapiens_hsa034601.33582388
36Regulation of autophagy_Homo sapiens_hsa041401.31317090
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26544608
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19358544
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17529237
40Olfactory transduction_Homo sapiens_hsa047401.14624079
41Selenocompound metabolism_Homo sapiens_hsa004501.08580454
42Parkinsons disease_Homo sapiens_hsa050121.08566974
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05903639
44ABC transporters_Homo sapiens_hsa020101.05061386
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03472270
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93570890
47Ether lipid metabolism_Homo sapiens_hsa005650.90389739
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89438429
49One carbon pool by folate_Homo sapiens_hsa006700.89425281
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88835024
51Tryptophan metabolism_Homo sapiens_hsa003800.87630387
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85169708
53Morphine addiction_Homo sapiens_hsa050320.83381305
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.83163117
55Alzheimers disease_Homo sapiens_hsa050100.81100093
56Arachidonic acid metabolism_Homo sapiens_hsa005900.78726349
57RNA polymerase_Homo sapiens_hsa030200.77774571
58Retinol metabolism_Homo sapiens_hsa008300.74563721
59T cell receptor signaling pathway_Homo sapiens_hsa046600.72042627
60Peroxisome_Homo sapiens_hsa041460.69412245
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65864053
62Chemical carcinogenesis_Homo sapiens_hsa052040.65108801
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.64706971
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.64408615
65Taste transduction_Homo sapiens_hsa047420.63698190
66Collecting duct acid secretion_Homo sapiens_hsa049660.61034868
67Cardiac muscle contraction_Homo sapiens_hsa042600.60976572
68Mismatch repair_Homo sapiens_hsa034300.60545549
69Nucleotide excision repair_Homo sapiens_hsa034200.60271991
70Huntingtons disease_Homo sapiens_hsa050160.57650524
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56954824
72Salivary secretion_Homo sapiens_hsa049700.56417768
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55777867
74Dorso-ventral axis formation_Homo sapiens_hsa043200.55523452
75Measles_Homo sapiens_hsa051620.53719453
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53230027
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.52229218
78Insulin secretion_Homo sapiens_hsa049110.50682655
79Fatty acid biosynthesis_Homo sapiens_hsa000610.50170500
80Purine metabolism_Homo sapiens_hsa002300.49577236
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48133949
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47442342
83Sulfur metabolism_Homo sapiens_hsa009200.45253242
84Glutamatergic synapse_Homo sapiens_hsa047240.45010805
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44737750
86Mineral absorption_Homo sapiens_hsa049780.41241514
87Staphylococcus aureus infection_Homo sapiens_hsa051500.41096708
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39697517
89African trypanosomiasis_Homo sapiens_hsa051430.38744161
90Calcium signaling pathway_Homo sapiens_hsa040200.38374310
91Serotonergic synapse_Homo sapiens_hsa047260.37074197
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33789084
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.33336656
94Fatty acid degradation_Homo sapiens_hsa000710.30102623
95GABAergic synapse_Homo sapiens_hsa047270.29551840
96Pyrimidine metabolism_Homo sapiens_hsa002400.29125231
97Circadian entrainment_Homo sapiens_hsa047130.28701179
98Metabolic pathways_Homo sapiens_hsa011000.28494318
99Fat digestion and absorption_Homo sapiens_hsa049750.27940669
100p53 signaling pathway_Homo sapiens_hsa041150.27443599

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