KAT14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)6.55756009
2DNA synthesis involved in DNA repair (GO:0000731)5.66958807
3chromosome organization involved in meiosis (GO:0070192)5.30660502
4establishment of integrated proviral latency (GO:0075713)5.20209383
5male meiosis I (GO:0007141)4.98580932
6mitotic sister chromatid cohesion (GO:0007064)4.86173875
7synaptonemal complex assembly (GO:0007130)4.56354075
8piRNA metabolic process (GO:0034587)4.44559709
9meiosis I (GO:0007127)4.34498751
10sister chromatid cohesion (GO:0007062)4.21077998
11synaptonemal complex organization (GO:0070193)4.15886538
12meiotic nuclear division (GO:0007126)3.95821716
13proteasome assembly (GO:0043248)3.95781080
14regulation of meiosis I (GO:0060631)3.92061578
15establishment of viral latency (GO:0019043)3.86764215
16CENP-A containing nucleosome assembly (GO:0034080)3.83928004
17chromatin remodeling at centromere (GO:0031055)3.83730625
18ribosome assembly (GO:0042255)3.80962859
19DNA ligation (GO:0006266)3.79735616
20histone exchange (GO:0043486)3.68757038
21meiotic cell cycle process (GO:1903046)3.61013262
22DNA strand elongation involved in DNA replication (GO:0006271)3.50196770
23IMP metabolic process (GO:0046040)3.46969983
24regulation of DNA endoreduplication (GO:0032875)3.43069402
25male meiosis (GO:0007140)3.38839063
26DNA replication checkpoint (GO:0000076)3.37346212
27mitotic metaphase plate congression (GO:0007080)3.37236378
28DNA strand elongation (GO:0022616)3.35406402
29non-recombinational repair (GO:0000726)3.34910798
30double-strand break repair via nonhomologous end joining (GO:0006303)3.34910798
31IMP biosynthetic process (GO:0006188)3.33646139
32resolution of meiotic recombination intermediates (GO:0000712)3.29033963
33reciprocal DNA recombination (GO:0035825)3.28409573
34reciprocal meiotic recombination (GO:0007131)3.28409573
35DNA double-strand break processing (GO:0000729)3.18921502
36DNA replication-independent nucleosome assembly (GO:0006336)3.18855539
37DNA replication-independent nucleosome organization (GO:0034724)3.18855539
38negative regulation of mitotic sister chromatid separation (GO:2000816)3.18828692
39negative regulation of sister chromatid segregation (GO:0033046)3.18828692
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18828692
41negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18828692
42negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18828692
43mitotic spindle checkpoint (GO:0071174)3.17654605
44negative regulation of chromosome segregation (GO:0051985)3.14580920
45telomere maintenance via semi-conservative replication (GO:0032201)3.12335549
46chaperone-mediated protein transport (GO:0072321)3.11527810
47regulation of transcription from RNA polymerase I promoter (GO:0006356)3.09241727
48spindle checkpoint (GO:0031577)3.08399417
49mitotic spindle assembly checkpoint (GO:0007094)3.06081895
50hyperosmotic salinity response (GO:0042538)3.05298567
51purine nucleobase biosynthetic process (GO:0009113)3.02492839
52protein localization to kinetochore (GO:0034501)3.01217092
53DNA methylation involved in gamete generation (GO:0043046)3.00265401
54spindle assembly checkpoint (GO:0071173)2.99892809
55DNA unwinding involved in DNA replication (GO:0006268)2.97703716
56DNA damage response, detection of DNA damage (GO:0042769)2.97315653
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96495519
58DNA replication-dependent nucleosome assembly (GO:0006335)2.92019701
59DNA replication-dependent nucleosome organization (GO:0034723)2.92019701
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91365673
61ATP-dependent chromatin remodeling (GO:0043044)2.84935099
62establishment of protein localization to mitochondrial membrane (GO:0090151)2.83430538
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83058673
64regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82473849
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82473849
66DNA catabolic process, exonucleolytic (GO:0000738)2.81681485
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81248903
68regulation of histone H3-K9 methylation (GO:0051570)2.80595669
69nuclear pore complex assembly (GO:0051292)2.79132114
70regulation of sister chromatid segregation (GO:0033045)2.78502414
71regulation of mitotic sister chromatid separation (GO:0010965)2.78502414
72regulation of mitotic sister chromatid segregation (GO:0033047)2.78502414
73histone H2A acetylation (GO:0043968)2.78388681
74metaphase plate congression (GO:0051310)2.77881751
75mitotic chromosome condensation (GO:0007076)2.75880972
76regulation of chromosome segregation (GO:0051983)2.74832510
77formation of translation preinitiation complex (GO:0001731)2.73642894
78negative regulation of mitosis (GO:0045839)2.71969422
79negative regulation of gene silencing (GO:0060969)2.70601076
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.70279825
81DNA replication initiation (GO:0006270)2.67962379
82tricarboxylic acid cycle (GO:0006099)2.67306851
83L-serine metabolic process (GO:0006563)2.65002695
84positive regulation of meiotic cell cycle (GO:0051446)2.61562590
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.61511153
86negative regulation of ligase activity (GO:0051352)2.60039152
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60039152
88protein localization to chromosome, centromeric region (GO:0071459)2.59663479
89nucleobase biosynthetic process (GO:0046112)2.59115669
90meiotic chromosome segregation (GO:0045132)2.58828330
91telomere maintenance via recombination (GO:0000722)2.57928208
92negative regulation of nuclear division (GO:0051784)2.55906840
93gene silencing by RNA (GO:0031047)2.55630770
94mitotic sister chromatid segregation (GO:0000070)2.52933354
95chromosome organization (GO:0051276)2.52486889
96positive regulation of ligase activity (GO:0051351)2.51924234
97regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.50835742
98nuclear pore organization (GO:0006999)2.50170850
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.47346987
100telomere maintenance via telomere lengthening (GO:0010833)2.46176485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60543486
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08002151
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.62716732
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49868343
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.40234505
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24748019
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.99003808
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96469585
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.90319124
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73747739
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62075654
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55333737
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48226525
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47720242
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47151540
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.45926308
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.45565581
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.45390136
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40824664
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39804766
21POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.34816269
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.33983773
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32380442
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32052558
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26510310
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23855502
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.22361532
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12563323
29AR_21909140_ChIP-Seq_LNCAP_Human2.06463590
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05624738
31ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02667993
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.00054143
33FOXP3_21729870_ChIP-Seq_TREG_Human1.92976337
34VDR_23849224_ChIP-Seq_CD4+_Human1.86992875
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86425782
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85762079
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.82434844
38GABP_19822575_ChIP-Seq_HepG2_Human1.82198721
39DCP1A_22483619_ChIP-Seq_HELA_Human1.81809904
40TTF2_22483619_ChIP-Seq_HELA_Human1.79244449
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78788572
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77804935
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.72260797
44ELK1_19687146_ChIP-ChIP_HELA_Human1.70618854
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65854196
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60787195
47XRN2_22483619_ChIP-Seq_HELA_Human1.59843510
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58569127
49CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57430791
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53600528
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47909067
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46227682
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43198547
54NANOG_16153702_ChIP-ChIP_HESCs_Human1.36145754
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34910117
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29924735
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.28131881
58KDM5A_27292631_Chip-Seq_BREAST_Human1.25528258
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24311472
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.23889331
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.23778329
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.16827252
63IGF1R_20145208_ChIP-Seq_DFB_Human1.15029534
64SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14995775
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13906013
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13699319
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13182665
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12639682
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12267510
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12267510
71KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12267510
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11591373
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11391936
74ZNF274_21170338_ChIP-Seq_K562_Hela1.11363690
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06921860
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04305132
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03021295
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02751138
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02745448
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02561178
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95704275
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95325310
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95212883
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94897754
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.94286219
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91167702
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91109304
88MYC_18940864_ChIP-ChIP_HL60_Human0.89908577
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89171065
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88890246
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87368725
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86942153
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85013855
94CIITA_25753668_ChIP-Seq_RAJI_Human0.84590226
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83901019
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82675858
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82217156
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81463468
99TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77949251
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77335794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.51902252
2MP0008058_abnormal_DNA_repair3.99785803
3MP0003693_abnormal_embryo_hatching3.89573214
4MP0010094_abnormal_chromosome_stability3.35534382
5MP0004957_abnormal_blastocyst_morpholog3.06533320
6MP0008057_abnormal_DNA_replication2.70579577
7MP0003111_abnormal_nucleus_morphology2.48843708
8MP0003941_abnormal_skin_development2.34554092
9MP0002210_abnormal_sex_determination2.10017254
10MP0003077_abnormal_cell_cycle2.09225255
11MP0009672_abnormal_birth_weight2.05541450
12MP0003123_paternal_imprinting2.01645995
13MP0008932_abnormal_embryonic_tissue1.97405481
14MP0001730_embryonic_growth_arrest1.97302772
15MP0008007_abnormal_cellular_replicative1.88971590
16MP0003890_abnormal_embryonic-extraembry1.85664962
17MP0003567_abnormal_fetal_cardiomyocyte1.83973122
18MP0001929_abnormal_gametogenesis1.78381716
19MP0001145_abnormal_male_reproductive1.78262319
20MP0006035_abnormal_mitochondrial_morpho1.73849756
21MP0003718_maternal_effect1.68469651
22MP0003646_muscle_fatigue1.65933116
23MP0000653_abnormal_sex_gland1.57534810
24MP0010030_abnormal_orbit_morphology1.57030677
25MP0003787_abnormal_imprinting1.53850809
26MP0002160_abnormal_reproductive_system1.45006612
27MP0003880_abnormal_central_pattern1.44152228
28MP0001697_abnormal_embryo_size1.39336139
29MP0000751_myopathy1.36726548
30MP0009703_decreased_birth_body1.35438636
31MP0005380_embryogenesis_phenotype1.34544501
32MP0001672_abnormal_embryogenesis/_devel1.34544501
33MP0002084_abnormal_developmental_patter1.34172353
34MP0001293_anophthalmia1.31099533
35MP0006036_abnormal_mitochondrial_physio1.30424539
36MP0002085_abnormal_embryonic_tissue1.28873908
37MP0000350_abnormal_cell_proliferation1.27749821
38MP0003119_abnormal_digestive_system1.27009418
39MP0003698_abnormal_male_reproductive1.24339005
40MP0003121_genomic_imprinting1.23777616
41MP0003937_abnormal_limbs/digits/tail_de1.19981309
42MP0005423_abnormal_somatic_nervous1.19031836
43MP0008789_abnormal_olfactory_epithelium1.18776593
44MP0002080_prenatal_lethality1.16381192
45MP0003984_embryonic_growth_retardation1.16201403
46MP0002088_abnormal_embryonic_growth/wei1.14765886
47MP0000647_abnormal_sebaceous_gland1.13143733
48MP0003122_maternal_imprinting1.04433221
49MP0006292_abnormal_olfactory_placode1.03190627
50MP0005330_cardiomyopathy1.02755120
51MP0001764_abnormal_homeostasis1.02476189
52MP0001119_abnormal_female_reproductive1.02096500
53MP0005394_taste/olfaction_phenotype1.02072651
54MP0005499_abnormal_olfactory_system1.02072651
55MP0002697_abnormal_eye_size1.00135960
56MP0004270_analgesia0.99109552
57MP0002269_muscular_atrophy0.96877841
58MP0000749_muscle_degeneration0.96788474
59MP0003786_premature_aging0.94470405
60MP0003861_abnormal_nervous_system0.93993043
61MP0002796_impaired_skin_barrier0.93394441
62MP0004264_abnormal_extraembryonic_tissu0.93253000
63MP0003315_abnormal_perineum_morphology0.91808001
64MP0004215_abnormal_myocardial_fiber0.91501298
65MP0000358_abnormal_cell_content/0.90230397
66MP0002233_abnormal_nose_morphology0.89647784
67MP0002161_abnormal_fertility/fecundity0.89052668
68MP0002254_reproductive_system_inflammat0.88933014
69MP0001188_hyperpigmentation0.88148745
70MP0004133_heterotaxia0.87971067
71MP0000778_abnormal_nervous_system0.86892972
72MP0005451_abnormal_body_composition0.86547838
73MP0004197_abnormal_fetal_growth/weight/0.86383725
74MP0001177_atelectasis0.86244336
75MP0003699_abnormal_female_reproductive0.84034341
76MP0002938_white_spotting0.83605136
77MP0008260_abnormal_autophagy0.83414828
78MP0001529_abnormal_vocalization0.81668830
79MP0002009_preneoplasia0.81269963
80MP0001299_abnormal_eye_distance/0.80425596
81MP0002106_abnormal_muscle_physiology0.80206980
82MP0002751_abnormal_autonomic_nervous0.79713672
83MP0000313_abnormal_cell_death0.79259355
84MP0001346_abnormal_lacrimal_gland0.78704226
85MP0001984_abnormal_olfaction0.78484581
86MP0004145_abnormal_muscle_electrophysio0.76794893
87MP0009379_abnormal_foot_pigmentation0.74754221
88MP0008995_early_reproductive_senescence0.73282705
89MP0009697_abnormal_copulation0.71650555
90MP0004147_increased_porphyrin_level0.70637500
91MP0002086_abnormal_extraembryonic_tissu0.70257330
92MP0004087_abnormal_muscle_fiber0.68892357
93MP0004859_abnormal_synaptic_plasticity0.68277341
94MP0002837_dystrophic_cardiac_calcinosis0.67298657
95MP0002102_abnormal_ear_morphology0.67123366
96MP0003936_abnormal_reproductive_system0.66523401
97MP0005645_abnormal_hypothalamus_physiol0.65594703
98MP0000747_muscle_weakness0.65444406
99MP0000427_abnormal_hair_cycle0.65331385
100MP0005389_reproductive_system_phenotype0.65107963

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.56541593
2Microvesicular hepatic steatosis (HP:0001414)2.97581128
3Hyperglycinemia (HP:0002154)2.91476624
4Colon cancer (HP:0003003)2.88153375
5Hepatoblastoma (HP:0002884)2.88029963
6Gonadotropin excess (HP:0000837)2.85763075
7Nemaline bodies (HP:0003798)2.84989980
8Exercise-induced muscle cramps (HP:0003710)2.81146340
9Abnormality of methionine metabolism (HP:0010901)2.79936309
10Chromsome breakage (HP:0040012)2.77502229
11Abnormal lung lobation (HP:0002101)2.70782237
12Abnormality of the labia minora (HP:0012880)2.68934118
13Shoulder girdle muscle weakness (HP:0003547)2.66204949
14Multiple enchondromatosis (HP:0005701)2.64824142
15Nephroblastoma (Wilms tumor) (HP:0002667)2.62782231
16Spontaneous abortion (HP:0005268)2.61940049
17Muscle fiber inclusion bodies (HP:0100299)2.61377274
18Type I transferrin isoform profile (HP:0003642)2.56963484
19Embryonal renal neoplasm (HP:0011794)2.54843869
20Abnormality of chromosome stability (HP:0003220)2.53499551
21Hyperglycinuria (HP:0003108)2.53353276
22Rimmed vacuoles (HP:0003805)2.52900848
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.51990969
24Abnormality of glycine metabolism (HP:0010895)2.51618444
25Abnormality of serine family amino acid metabolism (HP:0010894)2.51618444
26Hyperinsulinemic hypoglycemia (HP:0000825)2.46743342
27Meckel diverticulum (HP:0002245)2.41789440
28Hypoglycemic seizures (HP:0002173)2.35959631
29Abnormality of the ileum (HP:0001549)2.29663952
30Abnormality of serum amino acid levels (HP:0003112)2.28802325
31Ependymoma (HP:0002888)2.27593848
32Cerebral hypomyelination (HP:0006808)2.21505898
33Osteomalacia (HP:0002749)2.20475097
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16946384
35Increased nuchal translucency (HP:0010880)2.16913681
36Abnormality of the preputium (HP:0100587)2.12717444
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12460992
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12460992
39Progressive external ophthalmoplegia (HP:0000590)2.12084700
40CNS hypomyelination (HP:0003429)2.11253262
41Pancreatic islet-cell hyperplasia (HP:0004510)2.10951945
42Reduced antithrombin III activity (HP:0001976)2.08041880
43Hyperalaninemia (HP:0003348)2.06011442
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06011442
45Abnormality of alanine metabolism (HP:0010916)2.06011442
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04999995
47Acute encephalopathy (HP:0006846)1.99875384
48Rhabdomyolysis (HP:0003201)1.99661813
49Degeneration of anterior horn cells (HP:0002398)1.98505381
50Abnormality of the anterior horn cell (HP:0006802)1.98505381
51Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95835275
52Abnormal protein N-linked glycosylation (HP:0012347)1.95835275
53Abnormal protein glycosylation (HP:0012346)1.95835275
54Abnormal glycosylation (HP:0012345)1.95835275
55Hypoglycemic coma (HP:0001325)1.95063474
56Rhabdomyosarcoma (HP:0002859)1.93911501
57Supernumerary spleens (HP:0009799)1.91219139
58Abnormality of the musculature of the pelvis (HP:0001469)1.87640834
59Abnormality of the hip-girdle musculature (HP:0001445)1.87640834
60Increased serum pyruvate (HP:0003542)1.87041051
61Megaloblastic anemia (HP:0001889)1.83227517
62Prominent metopic ridge (HP:0005487)1.82655050
63Hypobetalipoproteinemia (HP:0003563)1.82025951
64Papillary thyroid carcinoma (HP:0002895)1.81544118
65Urinary urgency (HP:0000012)1.81103546
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79620910
67Degeneration of the lateral corticospinal tracts (HP:0002314)1.79620910
68Acute necrotizing encephalopathy (HP:0006965)1.79350257
69Aplasia/Hypoplasia of the sternum (HP:0006714)1.78460988
70Horseshoe kidney (HP:0000085)1.78302403
71Increased hepatocellular lipid droplets (HP:0006565)1.78107894
72Methylmalonic acidemia (HP:0002912)1.77623373
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.77570482
74Abnormality of the septum pellucidum (HP:0007375)1.76005661
75Medulloblastoma (HP:0002885)1.75550979
76Gout (HP:0001997)1.75397890
77Bifid tongue (HP:0010297)1.74892979
78Increased CSF lactate (HP:0002490)1.73110308
79Embryonal neoplasm (HP:0002898)1.72955540
80Progressive muscle weakness (HP:0003323)1.72929563
81Maternal diabetes (HP:0009800)1.72523186
82Abnormal mitochondria in muscle tissue (HP:0008316)1.71860420
83Respiratory difficulties (HP:0002880)1.71577989
84Azoospermia (HP:0000027)1.68402294
85Abnormal hair whorl (HP:0010721)1.67651791
86Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66820914
87Cerebral edema (HP:0002181)1.66640752
88Myoglobinuria (HP:0002913)1.65242183
89Neoplasm of the colon (HP:0100273)1.64761423
90Facial cleft (HP:0002006)1.64321238
91Duodenal stenosis (HP:0100867)1.64005232
92Small intestinal stenosis (HP:0012848)1.64005232
93Hepatocellular necrosis (HP:0001404)1.63987425
94Abnormality of the metopic suture (HP:0005556)1.63207225
95Birth length less than 3rd percentile (HP:0003561)1.62631072
96Septo-optic dysplasia (HP:0100842)1.62188733
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.61952579
98Impaired vibration sensation in the lower limbs (HP:0002166)1.61840241
99Cortical dysplasia (HP:0002539)1.58959587
100Lipid accumulation in hepatocytes (HP:0006561)1.58024103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.44112494
2SRPK13.50802350
3STK163.19847883
4PNCK3.02135695
5PBK3.02086272
6PDK22.83431258
7CDC72.81063471
8TSSK62.67928902
9TTK2.67913235
10BUB12.53533921
11SCYL22.16165853
12MST42.02561911
13NEK12.01091551
14PLK41.87437417
15OBSCN1.86795996
16PASK1.81307645
17VRK21.76883540
18PLK11.69318786
19BRSK21.68288331
20MAP3K91.59123204
21PLK31.53346349
22MAP3K41.49780291
23NME11.40703631
24CCNB11.37845074
25ATR1.37844631
26BRSK11.34775898
27EIF2AK31.34389468
28VRK11.30062913
29ACVR1B1.28989415
30EPHA41.26524501
31TRIM281.22063938
32CAMK1G1.13058743
33ZAK1.12153609
34TAF11.09711599
35NLK1.07798162
36CASK1.06923197
37WEE11.06307313
38STK38L1.06175765
39PHKG11.06053207
40PHKG21.06053207
41MKNK11.05383191
42OXSR11.02280948
43CHEK10.99474704
44BCR0.96880032
45WNK30.92325106
46TNIK0.91604215
47MAP3K100.91384727
48AURKB0.88247939
49ATM0.84014159
50MAP3K130.82986828
51EIF2AK10.82401847
52AURKA0.81085942
53CDK30.73657951
54MAP2K70.73555482
55DMPK0.71846681
56CSNK1G10.69193420
57CDK70.68240253
58TESK20.68010550
59CHEK20.67743573
60MKNK20.67129060
61CSNK1E0.64559093
62NUAK10.63542238
63BRD40.62276202
64CDK11A0.61761412
65CDK20.61671980
66DAPK10.61581784
67CSNK1G20.60699710
68NEK60.60025968
69UHMK10.57835189
70CSNK2A20.57755495
71ALK0.57594123
72NEK20.56041276
73RPS6KB10.54308855
74FGR0.54234266
75CDK10.52766172
76TYRO30.52444296
77PRKDC0.51931089
78ERBB40.49932062
79CDK180.49402593
80CDK140.48362514
81DYRK20.46910132
82MINK10.46712727
83CDK150.46414631
84BRAF0.46017610
85PRKCG0.45942765
86CDK40.45359903
87CSNK2A10.45040036
88MAP3K120.41096235
89AKT20.38990459
90PRKCI0.38782156
91FGFR10.38191802
92MET0.37208089
93RPS6KA40.36373126
94LATS20.35205286
95CSF1R0.33986396
96STK390.33969431
97STK40.31661492
98CSNK1G30.31540507
99RPS6KB20.30484875
100PRKACB0.30095796

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.62063012
2DNA replication_Homo sapiens_hsa030303.46307805
3Mismatch repair_Homo sapiens_hsa034303.24696813
4Proteasome_Homo sapiens_hsa030503.11410300
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.51548320
6RNA transport_Homo sapiens_hsa030132.37529626
7Homologous recombination_Homo sapiens_hsa034402.36252609
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35839638
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.25024570
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15615585
11Base excision repair_Homo sapiens_hsa034102.07296477
12RNA polymerase_Homo sapiens_hsa030202.05885371
13Nucleotide excision repair_Homo sapiens_hsa034201.95604015
14Cell cycle_Homo sapiens_hsa041101.95149971
15Spliceosome_Homo sapiens_hsa030401.88090764
16Ribosome_Homo sapiens_hsa030101.87499397
17Propanoate metabolism_Homo sapiens_hsa006401.83627448
18RNA degradation_Homo sapiens_hsa030181.77312884
19Pyruvate metabolism_Homo sapiens_hsa006201.69813193
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.67069392
21Fanconi anemia pathway_Homo sapiens_hsa034601.63670588
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63529589
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61730684
24mRNA surveillance pathway_Homo sapiens_hsa030151.60024811
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59561872
26Fatty acid elongation_Homo sapiens_hsa000621.56701699
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54354378
28Oocyte meiosis_Homo sapiens_hsa041141.49250757
29Basal transcription factors_Homo sapiens_hsa030221.48190398
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39357938
31Carbon metabolism_Homo sapiens_hsa012001.38043290
32Parkinsons disease_Homo sapiens_hsa050121.37406648
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37386486
34Oxidative phosphorylation_Homo sapiens_hsa001901.33917560
35Pyrimidine metabolism_Homo sapiens_hsa002401.30150417
36Selenocompound metabolism_Homo sapiens_hsa004501.29752815
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17355408
38Huntingtons disease_Homo sapiens_hsa050161.16581346
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15560431
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15206554
41Biosynthesis of amino acids_Homo sapiens_hsa012301.13610329
42Protein export_Homo sapiens_hsa030601.05567264
43Purine metabolism_Homo sapiens_hsa002301.03423231
44One carbon pool by folate_Homo sapiens_hsa006700.97174912
45Fatty acid metabolism_Homo sapiens_hsa012120.96863469
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93155579
47Vitamin B6 metabolism_Homo sapiens_hsa007500.92657132
48Steroid biosynthesis_Homo sapiens_hsa001000.91428333
49Vitamin digestion and absorption_Homo sapiens_hsa049770.90065763
50Folate biosynthesis_Homo sapiens_hsa007900.86399720
51Cardiac muscle contraction_Homo sapiens_hsa042600.85043876
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80645719
53Peroxisome_Homo sapiens_hsa041460.80136640
54Fatty acid degradation_Homo sapiens_hsa000710.80015083
55Regulation of autophagy_Homo sapiens_hsa041400.79753253
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79207506
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74388963
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73140314
59beta-Alanine metabolism_Homo sapiens_hsa004100.71270137
60Lysine degradation_Homo sapiens_hsa003100.68098296
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67745387
62Phenylalanine metabolism_Homo sapiens_hsa003600.65597884
63Alzheimers disease_Homo sapiens_hsa050100.64063556
64N-Glycan biosynthesis_Homo sapiens_hsa005100.63759858
65Fat digestion and absorption_Homo sapiens_hsa049750.63285520
66Sulfur relay system_Homo sapiens_hsa041220.61008335
67Butanoate metabolism_Homo sapiens_hsa006500.60460795
68Metabolic pathways_Homo sapiens_hsa011000.56574920
69Arginine and proline metabolism_Homo sapiens_hsa003300.53964737
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53942532
71Glutathione metabolism_Homo sapiens_hsa004800.52545243
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.52006597
73Arginine biosynthesis_Homo sapiens_hsa002200.51359345
74Wnt signaling pathway_Homo sapiens_hsa043100.50996185
75Hippo signaling pathway_Homo sapiens_hsa043900.50683506
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50251968
77Glucagon signaling pathway_Homo sapiens_hsa049220.49674093
78Thyroid cancer_Homo sapiens_hsa052160.48228723
79Tight junction_Homo sapiens_hsa045300.47571520
80Retinol metabolism_Homo sapiens_hsa008300.43364432
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.43232826
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41808188
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35354431
84Basal cell carcinoma_Homo sapiens_hsa052170.33450166
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33423651
86Synaptic vesicle cycle_Homo sapiens_hsa047210.31212041
87Hedgehog signaling pathway_Homo sapiens_hsa043400.30832191
88Collecting duct acid secretion_Homo sapiens_hsa049660.30473493
89p53 signaling pathway_Homo sapiens_hsa041150.29766521
90Adherens junction_Homo sapiens_hsa045200.28553921
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28342777
92Nicotine addiction_Homo sapiens_hsa050330.27352988
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.26487478
94Starch and sucrose metabolism_Homo sapiens_hsa005000.26340579
95Vibrio cholerae infection_Homo sapiens_hsa051100.25601819
96Pentose phosphate pathway_Homo sapiens_hsa000300.25298955
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.22122494
98Tyrosine metabolism_Homo sapiens_hsa003500.21899734
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21392882
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.20166131

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