KAT2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.62159530
2negative regulation of erythrocyte differentiation (GO:0045647)5.18139407
3regulation of translational fidelity (GO:0006450)4.54007653
4mannose metabolic process (GO:0006013)4.44992608
5protein localization to kinetochore (GO:0034501)4.42002650
6folic acid-containing compound biosynthetic process (GO:0009396)4.40091611
7negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.38966807
8DNA strand elongation involved in DNA replication (GO:0006271)4.33060357
9nuclear pore organization (GO:0006999)4.30892517
10pre-miRNA processing (GO:0031054)4.26599864
11mitotic nuclear envelope disassembly (GO:0007077)4.25677979
12formation of translation preinitiation complex (GO:0001731)4.24934286
13peptidyl-arginine omega-N-methylation (GO:0035247)4.22830175
14IMP biosynthetic process (GO:0006188)4.21507913
15DNA replication initiation (GO:0006270)4.17751240
16DNA strand elongation (GO:0022616)4.06675890
17nuclear pore complex assembly (GO:0051292)4.04321070
18membrane disassembly (GO:0030397)4.03366677
19nuclear envelope disassembly (GO:0051081)4.03366677
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.01488868
21regulation of gene silencing by RNA (GO:0060966)4.00037928
22regulation of posttranscriptional gene silencing (GO:0060147)4.00037928
23regulation of gene silencing by miRNA (GO:0060964)4.00037928
24regulation of translational termination (GO:0006449)4.00027446
25proline biosynthetic process (GO:0006561)3.91244449
26negative regulation of RNA splicing (GO:0033119)3.87693385
27heterochromatin organization (GO:0070828)3.87009052
28maturation of SSU-rRNA (GO:0030490)3.79365385
29sodium ion export (GO:0071436)3.78870813
30positive regulation of synapse maturation (GO:0090129)3.78619916
31nucleobase biosynthetic process (GO:0046112)3.76389814
32IMP metabolic process (GO:0046040)3.75017557
33negative regulation of mRNA processing (GO:0050686)3.73717368
34histone arginine methylation (GO:0034969)3.73110292
35DNA duplex unwinding (GO:0032508)3.69424819
36DNA replication-dependent nucleosome assembly (GO:0006335)3.68127038
37DNA replication-dependent nucleosome organization (GO:0034723)3.68127038
38regulation of ARF GTPase activity (GO:0032312)3.66483811
39peptidyl-arginine methylation (GO:0018216)3.66406427
40peptidyl-arginine N-methylation (GO:0035246)3.66406427
41DNA geometric change (GO:0032392)3.66224253
42regulation of mammary gland epithelial cell proliferation (GO:0033599)3.63347856
43telomere maintenance via semi-conservative replication (GO:0032201)3.60826110
44COPI coating of Golgi vesicle (GO:0048205)3.59804382
45Golgi transport vesicle coating (GO:0048200)3.59804382
46protein localization to chromosome, centromeric region (GO:0071459)3.58873269
47regulation of cholesterol biosynthetic process (GO:0045540)3.56301636
48regulation of histone H3-K27 methylation (GO:0061085)3.56183936
49protein retention in ER lumen (GO:0006621)3.54330542
50ribosome biogenesis (GO:0042254)3.52931823
51negative regulation of mRNA metabolic process (GO:1903312)3.51934368
52viral transcription (GO:0019083)3.51163323
53activation of Rac GTPase activity (GO:0032863)3.51065641
54adherens junction assembly (GO:0034333)3.49860258
55translational termination (GO:0006415)3.45778562
56negative regulation of cell size (GO:0045792)3.44220278
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43472545
58focal adhesion assembly (GO:0048041)3.40872569
59cell-substrate adherens junction assembly (GO:0007045)3.40872569
60ribosomal small subunit assembly (GO:0000028)3.38325538
61negative regulation of histone methylation (GO:0031061)3.37733811
62regulation of ARF protein signal transduction (GO:0032012)3.36396877
63mitotic sister chromatid segregation (GO:0000070)3.36340394
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.34675708
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.33689678
66cytoskeletal anchoring at plasma membrane (GO:0007016)3.33317632
67translational initiation (GO:0006413)3.31786808
68translational elongation (GO:0006414)3.31701913
69apoptotic process involved in morphogenesis (GO:0060561)3.31288488
70ribosome assembly (GO:0042255)3.30036595
71mitotic G1 DNA damage checkpoint (GO:0031571)3.30031401
72proline metabolic process (GO:0006560)3.29931413
73nuclear envelope organization (GO:0006998)3.29323535
74planar cell polarity pathway involved in neural tube closure (GO:0090179)3.24779068
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24233794
76semaphorin-plexin signaling pathway (GO:0071526)3.20154394
77sister chromatid segregation (GO:0000819)3.17958679
78regulation of histone H3-K9 methylation (GO:0051570)3.17780132
79dosage compensation (GO:0007549)3.15933855
80mitotic metaphase plate congression (GO:0007080)3.15248733
81DNA replication checkpoint (GO:0000076)3.13175891
82activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.12876078
83ribonucleoprotein complex biogenesis (GO:0022613)3.12742718
84spliceosomal tri-snRNP complex assembly (GO:0000244)3.12338401
85RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11850457
86mRNA splicing, via spliceosome (GO:0000398)3.11850457
87positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.10891060
88RNA splicing, via transesterification reactions (GO:0000375)3.09099785
89purine nucleobase biosynthetic process (GO:0009113)3.07713274
90positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.06270627
91regulation of early endosome to late endosome transport (GO:2000641)3.06060240
92telomere maintenance via telomere lengthening (GO:0010833)3.05055998
93positive regulation of nuclease activity (GO:0032075)3.04657056
94cell volume homeostasis (GO:0006884)3.02594064
95positive regulation of chromosome segregation (GO:0051984)3.01926453
96peptidyl-lysine dimethylation (GO:0018027)3.01882119
97telomere maintenance via recombination (GO:0000722)3.01014550
98regulation of glucose import in response to insulin stimulus (GO:2001273)3.00086918
99termination of RNA polymerase II transcription (GO:0006369)2.97821326
100mitotic chromosome condensation (GO:0007076)2.97483939
101regulation of cholesterol metabolic process (GO:0090181)2.97418460
102spliceosomal snRNP assembly (GO:0000387)2.96241869
103mitotic recombination (GO:0006312)2.95147939
104regulation of mitotic spindle organization (GO:0060236)2.94202205
105regulation of RNA export from nucleus (GO:0046831)2.93770655
106negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.90955464
107regulation of telomere maintenance via telomerase (GO:0032210)2.90955299
108regulation of synapse maturation (GO:0090128)2.90893522
109regulation of spindle organization (GO:0090224)2.90479787
110DNA deamination (GO:0045006)2.90204534
111pseudouridine synthesis (GO:0001522)2.89533050
112cell-cell junction maintenance (GO:0045217)2.88437631
113pore complex assembly (GO:0046931)2.88181080
114cellular response to epidermal growth factor stimulus (GO:0071364)2.87486590
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.87310028
116somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87310028
117cellular potassium ion homeostasis (GO:0030007)2.87230306
118maternal placenta development (GO:0001893)2.86996639
119amino acid import (GO:0043090)2.86692185
120regulation of translational elongation (GO:0006448)2.86520243
121regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.86094516
122mRNA transport (GO:0051028)2.86031411
123chromatin assembly (GO:0031497)2.85536737
124mitotic sister chromatid cohesion (GO:0007064)2.84837797
125DNA conformation change (GO:0071103)2.84784535
126histone H2A acetylation (GO:0043968)2.84205914
127ribosomal small subunit biogenesis (GO:0042274)2.84002134
128nucleotide-excision repair, DNA gap filling (GO:0006297)2.83964509
129rRNA processing (GO:0006364)2.83859866
130glutamate secretion (GO:0014047)2.82970488
131basement membrane organization (GO:0071711)2.82821262
132negative regulation of chromosome segregation (GO:0051985)2.81547806
133protein complex localization (GO:0031503)2.81101225
134protein complex disassembly (GO:0043241)2.79996252
135mitotic G1/S transition checkpoint (GO:0044819)2.79704729
136cerebellar granule cell differentiation (GO:0021707)2.79699928
137regulation of response to osmotic stress (GO:0047484)2.79292655
138cellular protein complex disassembly (GO:0043624)2.78844702
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78786962
140histone H4 deacetylation (GO:0070933)2.78459559
141entrainment of circadian clock by photoperiod (GO:0043153)2.78240043
142protein localization to chromosome (GO:0034502)2.77690283
143rRNA metabolic process (GO:0016072)2.76288116
144negative regulation of gene silencing (GO:0060969)2.76241017
145establishment of integrated proviral latency (GO:0075713)2.75719514
146G1 DNA damage checkpoint (GO:0044783)2.75288423
147intracellular estrogen receptor signaling pathway (GO:0030520)2.74936402
148stress granule assembly (GO:0034063)2.74525257
149establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.74498073
150mitochondrion transport along microtubule (GO:0047497)2.74498073
151RNA export from nucleus (GO:0006405)2.74430579
152chromatin assembly or disassembly (GO:0006333)2.73370432
153regulation of nuclease activity (GO:0032069)2.71764428
154creatine metabolic process (GO:0006600)2.70045686
155peptidyl-tyrosine autophosphorylation (GO:0038083)2.69935980
156layer formation in cerebral cortex (GO:0021819)2.68982694
157cellular hyperosmotic response (GO:0071474)2.67564203
158regulation of nucleobase-containing compound transport (GO:0032239)2.67273306
159poly(A)+ mRNA export from nucleus (GO:0016973)2.65630929
160synaptic vesicle exocytosis (GO:0016079)2.63619183
161snRNA metabolic process (GO:0016073)2.63285500
162cerebellar Purkinje cell layer development (GO:0021680)2.62332036
163glutamine family amino acid biosynthetic process (GO:0009084)2.61894400
164G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.58414229
165cell-substrate junction assembly (GO:0007044)2.57290489
166histone H3-K9 demethylation (GO:0033169)2.54992700
167positive regulation of extracellular matrix organization (GO:1903055)2.54887414
168positive regulation of CREB transcription factor activity (GO:0032793)2.53405568
169histone H3 deacetylation (GO:0070932)2.53222063
170lung epithelium development (GO:0060428)2.52400503
171positive regulation of protein dephosphorylation (GO:0035307)2.52210646
172L-amino acid import (GO:0043092)2.51371396
173neuromuscular process controlling balance (GO:0050885)2.47376931
174chondroitin sulfate catabolic process (GO:0030207)2.46708669
175response to epidermal growth factor (GO:0070849)2.45039012
176dicarboxylic acid biosynthetic process (GO:0043650)2.44435925
177protein targeting to plasma membrane (GO:0072661)2.43380101
178regulation of extracellular matrix disassembly (GO:0010715)2.43074726
179cellular sodium ion homeostasis (GO:0006883)2.43056208
180epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43004214
181activation of JUN kinase activity (GO:0007257)2.42158924
182NADH metabolic process (GO:0006734)2.41595888
183endoplasmic reticulum unfolded protein response (GO:0030968)2.41097288
184regulation of extracellular matrix organization (GO:1903053)2.39933529
185myelin maintenance (GO:0043217)2.39707117
186central nervous system myelination (GO:0022010)2.38455305
187axon ensheathment in central nervous system (GO:0032291)2.38455305
188oxaloacetate metabolic process (GO:0006107)2.38377958
189endothelial cell chemotaxis (GO:0035767)2.37240124
190regulation of chromatin binding (GO:0035561)2.36455071
191regulation of apoptotic cell clearance (GO:2000425)2.35829315
192insulin-like growth factor receptor signaling pathway (GO:0048009)2.35189568
193modulation by virus of host process (GO:0019054)2.32924678
194ER-nucleus signaling pathway (GO:0006984)2.32896446
195negative regulation of myotube differentiation (GO:0010832)2.31255442

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.73948482
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.16049363
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.05362564
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.80497262
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.42057972
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19671179
7MYC_22102868_ChIP-Seq_BL_Human3.00288419
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96165060
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.94489322
10LXR_22292898_ChIP-Seq_THP-1_Human2.90089610
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59790491
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53115555
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51947240
14XRN2_22483619_ChIP-Seq_HELA_Human2.37462075
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.37272853
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33081479
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18776529
18RACK7_27058665_Chip-Seq_MCF-7_Human2.13046413
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.11376557
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07869259
21CIITA_25753668_ChIP-Seq_RAJI_Human2.00032602
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99991639
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96731194
24KDM2B_26808549_Chip-Seq_K562_Human1.94349133
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88152426
26VDR_21846776_ChIP-Seq_THP-1_Human1.85429412
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.85113528
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83157261
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82005194
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.80722942
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79989533
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79672891
33P68_20966046_ChIP-Seq_HELA_Human1.79522989
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79240090
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.78641101
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76750716
37AR_21909140_ChIP-Seq_LNCAP_Human1.75573466
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73334609
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72368111
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72366390
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72035878
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71924603
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70262390
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.67968245
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65172473
46* TET1_21451524_ChIP-Seq_MESCs_Mouse1.63659529
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62523778
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62053262
49SMC4_20622854_ChIP-Seq_HELA_Human1.62002147
50TTF2_22483619_ChIP-Seq_HELA_Human1.61101926
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60422096
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59428600
53GABP_19822575_ChIP-Seq_HepG2_Human1.58768629
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58224072
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55495137
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54702251
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54172166
58CLOCK_20551151_ChIP-Seq_293T_Human1.54066336
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53989163
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53332830
61KDM5A_27292631_Chip-Seq_BREAST_Human1.53033421
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52863068
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51546309
64CREB1_26743006_Chip-Seq_LNCaP_Human1.51254104
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.51224273
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51100223
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50966811
68* SA1_27219007_Chip-Seq_ERYTHROID_Human1.50599008
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50528424
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49913492
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47987885
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45647293
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.45460745
74VDR_23849224_ChIP-Seq_CD4+_Human1.45036054
75FOXP3_21729870_ChIP-Seq_TREG_Human1.41322204
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41058214
77DCP1A_22483619_ChIP-Seq_HELA_Human1.40564571
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40083669
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38191958
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.34124906
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34059119
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33845147
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33645337
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.30706892
85KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29957844
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29509873
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29507102
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28526237
89TCF7_22412390_ChIP-Seq_EML_Mouse1.27977972
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27612341
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27388592
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27388592
93KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27388592
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26627350
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26612319
96RARB_27405468_Chip-Seq_BRAIN_Mouse1.26580756
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26103747
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25062891
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24681216
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.23175826
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22578299
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22279243
103KDM2B_26808549_Chip-Seq_DND41_Human1.21970360
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20820210
105MAF_26560356_Chip-Seq_TH2_Human1.20217878
106NCOR1_26117541_ChIP-Seq_K562_Human1.19925319
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18473896
108TFEB_21752829_ChIP-Seq_HELA_Human1.17359642
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.17358528
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.16909382
111CTCF_27219007_Chip-Seq_Bcells_Human1.16460751
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16208558
113ZNF263_19887448_ChIP-Seq_K562_Human1.16136265
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16129363
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15961753
116NANOG_21062744_ChIP-ChIP_HESCs_Human1.15858522
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15330954
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15173745
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14326129
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13691729
121VDR_24763502_ChIP-Seq_THP-1_Human1.12046696
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11657467
123NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11355547
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10438549
125MAF_26560356_Chip-Seq_TH1_Human1.09667227
126RUNX1_27514584_Chip-Seq_MCF-7_Human1.09492374
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09158549
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08976259
129BCOR_27268052_Chip-Seq_Bcells_Human1.08489241
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07566505
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07532086
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06344841
133* RARA_24833708_ChIP-Seq_LIVER_Mouse1.05978364
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05187622
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04463724
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03847033
137SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03141571
138ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02832056
139SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02454748
140RARB_24833708_ChIP-Seq_LIVER_Mouse1.01879593
141TET1_21490601_ChIP-Seq_MESCs_Mouse1.01862567
142E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00888865
143PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00773009
144* ETS1_21867929_ChIP-Seq_TH2_Mouse1.00097162
145GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99856215
146CTCF_26484167_Chip-Seq_Bcells_Mouse0.99795946
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99543223
148UTX_26944678_Chip-Seq_JUKART_Human0.99190194
149TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98591876
150TP53_22127205_ChIP-Seq_IMR90_Human0.98261909
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98232114
152* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98155052
153RXR_22158963_ChIP-Seq_LIVER_Mouse0.97201517
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95879316
155OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95667021
156TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94959993
157FOXP1_21924763_ChIP-Seq_HESCs_Human0.94601210
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93316228
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90168512
160DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89094582
161* ATF3_27146783_Chip-Seq_COLON_Human0.88562935
162CHD1_26751641_Chip-Seq_LNCaP_Human0.87953900
163TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87273735
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87238836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.21175165
2MP0004957_abnormal_blastocyst_morpholog4.14235778
3MP0003111_abnormal_nucleus_morphology4.08088931
4MP0010094_abnormal_chromosome_stability3.87524636
5MP0003077_abnormal_cell_cycle3.55882720
6MP0008057_abnormal_DNA_replication3.31614941
7MP0004859_abnormal_synaptic_plasticity3.16802642
8MP0005058_abnormal_lysosome_morphology3.07501333
9MP0010352_gastrointestinal_tract_polyps2.99755881
10MP0003172_abnormal_lysosome_physiology2.93860154
11MP0003123_paternal_imprinting2.80153551
12* MP0001730_embryonic_growth_arrest2.79257839
13MP0000566_synostosis2.74816531
14MP0005409_darkened_coat_color2.66378856
15MP0002396_abnormal_hematopoietic_system2.61134670
16MP0000678_abnormal_parathyroid_gland2.51743479
17MP0005451_abnormal_body_composition2.49633814
18MP0004858_abnormal_nervous_system2.46891048
19* MP0000350_abnormal_cell_proliferation2.39542815
20MP0008007_abnormal_cellular_replicative2.39016337
21MP0008058_abnormal_DNA_repair2.27373166
22MP0004185_abnormal_adipocyte_glucose2.25749967
23MP0008260_abnormal_autophagy2.23482997
24MP0005666_abnormal_adipose_tissue2.23445958
25MP0010030_abnormal_orbit_morphology2.20736121
26MP0008932_abnormal_embryonic_tissue2.15837200
27* MP0002084_abnormal_developmental_patter2.11227136
28MP0000003_abnormal_adipose_tissue2.10419745
29* MP0001697_abnormal_embryo_size2.09142845
30MP0003329_amyloid_beta_deposits2.06877613
31* MP0005380_embryogenesis_phenotype2.06417458
32* MP0001672_abnormal_embryogenesis/_devel2.06417458
33MP0005076_abnormal_cell_differentiation2.01420179
34* MP0002085_abnormal_embryonic_tissue2.01027629
35MP0004808_abnormal_hematopoietic_stem1.98181402
36MP0002653_abnormal_ependyma_morphology1.94602224
37* MP0002080_prenatal_lethality1.92036263
38* MP0003984_embryonic_growth_retardation1.90307548
39* MP0004197_abnormal_fetal_growth/weight/1.90287603
40* MP0002088_abnormal_embryonic_growth/wei1.86643571
41MP0005375_adipose_tissue_phenotype1.85534724
42MP0010307_abnormal_tumor_latency1.81447876
43* MP0002086_abnormal_extraembryonic_tissu1.79688302
44MP0008877_abnormal_DNA_methylation1.79316424
45MP0003705_abnormal_hypodermis_morpholog1.78996653
46MP0000537_abnormal_urethra_morphology1.78784552
47MP0003690_abnormal_glial_cell1.78457920
48MP0009278_abnormal_bone_marrow1.76962523
49MP0003121_genomic_imprinting1.63771372
50MP0000751_myopathy1.61753186
51MP0001293_anophthalmia1.61496432
52MP0008438_abnormal_cutaneous_collagen1.60411402
53MP0000490_abnormal_crypts_of1.54686543
54MP0005360_urolithiasis1.52173465
55MP0003119_abnormal_digestive_system1.49919418
56MP0009780_abnormal_chondrocyte_physiolo1.49802760
57MP0004233_abnormal_muscle_weight1.49696580
58MP0005397_hematopoietic_system_phenotyp1.49532675
59MP0001545_abnormal_hematopoietic_system1.49532675
60MP0001849_ear_inflammation1.48437651
61MP0001502_abnormal_circadian_rhythm1.48182841
62MP0005670_abnormal_white_adipose1.44404761
63* MP0000313_abnormal_cell_death1.42305230
64MP0008569_lethality_at_weaning1.39142151
65MP0003567_abnormal_fetal_cardiomyocyte1.32911268
66MP0003453_abnormal_keratinocyte_physiol1.32346400
67MP0003786_premature_aging1.25919928
68MP0009672_abnormal_birth_weight1.25606821
69MP0010630_abnormal_cardiac_muscle1.24411179
70MP0003634_abnormal_glial_cell1.24114778
71MP0005423_abnormal_somatic_nervous1.24089722
72MP0000703_abnormal_thymus_morphology1.23639381
73MP0000428_abnormal_craniofacial_morphol1.23245002
74MP0009840_abnormal_foam_cell1.23146611
75MP0003890_abnormal_embryonic-extraembry1.22948982
76MP0002019_abnormal_tumor_incidence1.22377454
77MP0000681_abnormal_thyroid_gland1.21366023
78MP0003879_abnormal_hair_cell1.21240067
79MP0004270_analgesia1.14286773
80MP0009053_abnormal_anal_canal1.13076084
81MP0003122_maternal_imprinting1.12740194
82MP0000733_abnormal_muscle_development1.12019552
83MP0004133_heterotaxia1.11122973
84MP0003635_abnormal_synaptic_transmissio1.10091221
85MP0000579_abnormal_nail_morphology1.09450718
86MP0003115_abnormal_respiratory_system1.09063313
87MP0000920_abnormal_myelination1.07410770
88MP0009384_cardiac_valve_regurgitation1.07345444
89* MP0003861_abnormal_nervous_system1.06097116
90MP0004087_abnormal_muscle_fiber1.05470781
91MP0005023_abnormal_wound_healing1.03654926
92MP0002089_abnormal_postnatal_growth/wei1.03324491
93MP0003283_abnormal_digestive_organ1.02927339
94MP0008961_abnormal_basal_metabolism1.02880912
95MP0001346_abnormal_lacrimal_gland1.02579500
96MP0006138_congestive_heart_failure1.02012517
97MP0002092_abnormal_eye_morphology0.99811156
98MP0003183_abnormal_peptide_metabolism0.99483335
99MP0006292_abnormal_olfactory_placode0.99253693
100* MP0008770_decreased_survivor_rate0.98964669
101MP0000358_abnormal_cell_content/0.98878285
102MP0000759_abnormal_skeletal_muscle0.97863612
103MP0004264_abnormal_extraembryonic_tissu0.97346338
104MP0003091_abnormal_cell_migration0.96351652
105MP0009703_decreased_birth_body0.96266981
106MP0004381_abnormal_hair_follicle0.94868083
107MP0003191_abnormal_cellular_cholesterol0.94550830
108MP0002111_abnormal_tail_morphology0.94377146
109MP0009333_abnormal_splenocyte_physiolog0.93601402
110MP0002210_abnormal_sex_determination0.93442244
111MP0000467_abnormal_esophagus_morphology0.92557414
112MP0001145_abnormal_male_reproductive0.92153094
113MP0001915_intracranial_hemorrhage0.91923732
114MP0002970_abnormal_white_adipose0.90552564
115MP0003566_abnormal_cell_adhesion0.90038436
116* MP0002925_abnormal_cardiovascular_devel0.87079545
117MP0002063_abnormal_learning/memory/cond0.86716015
118MP0002060_abnormal_skin_morphology0.86589780
119MP0005384_cellular_phenotype0.86116001
120MP0001958_emphysema0.86032823
121MP0000534_abnormal_ureter_morphology0.83129076
122MP0003075_altered_response_to0.82570549
123MP0003935_abnormal_craniofacial_develop0.81831092
124MP0005330_cardiomyopathy0.81377842
125MP0002722_abnormal_immune_system0.80974665
126MP0000013_abnormal_adipose_tissue0.80801134
127MP0002697_abnormal_eye_size0.80583025
128MP0002398_abnormal_bone_marrow0.80447696
129MP0005621_abnormal_cell_physiology0.79957938
130MP0000604_amyloidosis0.78874272
131MP0003436_decreased_susceptibility_to0.77944864
132MP0003763_abnormal_thymus_physiology0.77293402
133MP0002822_catalepsy0.76294083
134MP0002064_seizures0.75235494
135MP0002269_muscular_atrophy0.74806498
136MP0000858_altered_metastatic_potential0.74277649
137MP0000747_muscle_weakness0.74079561
138MP0002971_abnormal_brown_adipose0.72563410
139MP0000477_abnormal_intestine_morphology0.72362460
140MP0004947_skin_inflammation0.71111706
141MP0000049_abnormal_middle_ear0.70711526
142MP0001853_heart_inflammation0.70550120
143MP0005394_taste/olfaction_phenotype0.70461652
144MP0005499_abnormal_olfactory_system0.70461652
145MP0000266_abnormal_heart_morphology0.69819070
146MP0001929_abnormal_gametogenesis0.69611181
147MP0010234_abnormal_vibrissa_follicle0.69558946
148MP0002075_abnormal_coat/hair_pigmentati0.69425191
149MP0000653_abnormal_sex_gland0.68684877
150MP0001270_distended_abdomen0.67831818
151MP0002877_abnormal_melanocyte_morpholog0.66019305
152MP0002116_abnormal_craniofacial_bone0.65933109
153MP0001661_extended_life_span0.65516705
154MP0002796_impaired_skin_barrier0.64710459
155MP0000689_abnormal_spleen_morphology0.64684687
156MP0000371_diluted_coat_color0.64122520
157MP0003942_abnormal_urinary_system0.64064037
158MP0003937_abnormal_limbs/digits/tail_de0.64026226
159MP0008874_decreased_physiological_sensi0.63863328
160MP0001784_abnormal_fluid_regulation0.63822656
161MP0002932_abnormal_joint_morphology0.63513909
162* MP0002114_abnormal_axial_skeleton0.63283924
163MP0005623_abnormal_meninges_morphology0.63256972
164MP0002249_abnormal_larynx_morphology0.63025028
165MP0001348_abnormal_lacrimal_gland0.62723093
166MP0009931_abnormal_skin_appearance0.61594256
167MP0001299_abnormal_eye_distance/0.60581695

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.60238374
2Ependymoma (HP:0002888)4.56304106
3Selective tooth agenesis (HP:0001592)3.69146134
4Abnormality of the astrocytes (HP:0100707)3.37954854
5Astrocytoma (HP:0009592)3.37954854
6Hyperacusis (HP:0010780)3.32024399
7Medulloblastoma (HP:0002885)3.21705005
8Colon cancer (HP:0003003)3.21256622
9J-shaped sella turcica (HP:0002680)3.14746986
10Deep venous thrombosis (HP:0002625)3.10873089
11Increased nuchal translucency (HP:0010880)3.10321967
12Broad face (HP:0000283)3.00424250
13Protrusio acetabuli (HP:0003179)2.97977337
14Abnormality of cells of the erythroid lineage (HP:0012130)2.92917067
15Degeneration of anterior horn cells (HP:0002398)2.87611077
16Abnormality of the anterior horn cell (HP:0006802)2.87611077
17Basal cell carcinoma (HP:0002671)2.81867446
18Abnormal number of erythroid precursors (HP:0012131)2.81022781
19Stridor (HP:0010307)2.78639764
20Neoplasm of the oral cavity (HP:0100649)2.76359296
21Birth length less than 3rd percentile (HP:0003561)2.73919149
22Reticulocytopenia (HP:0001896)2.71093936
23Renal duplication (HP:0000075)2.70912694
24Abnormality of the lower motor neuron (HP:0002366)2.67344731
25Proximal placement of thumb (HP:0009623)2.66960865
26Neoplasm of striated muscle (HP:0009728)2.64836435
27Flat acetabular roof (HP:0003180)2.64832292
28Rhabdomyosarcoma (HP:0002859)2.60905268
29Biconcave vertebral bodies (HP:0004586)2.60480088
30Glioma (HP:0009733)2.60308597
31Abnormal number of incisors (HP:0011064)2.57067715
32Supranuclear gaze palsy (HP:0000605)2.56519814
33Shallow orbits (HP:0000586)2.54999421
34Deviation of the thumb (HP:0009603)2.53454588
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46884586
36Short 4th metacarpal (HP:0010044)2.46884586
37Cholecystitis (HP:0001082)2.43716132
38Abnormal gallbladder physiology (HP:0012438)2.43716132
39Achilles tendon contracture (HP:0001771)2.43671118
40Truncus arteriosus (HP:0001660)2.41617818
41Atrophy/Degeneration involving motor neurons (HP:0007373)2.40954733
42Abnormality of the labia minora (HP:0012880)2.40485712
43Missing ribs (HP:0000921)2.37413138
44Annular pancreas (HP:0001734)2.37147701
45Abnormality of the Achilles tendon (HP:0005109)2.36941210
46Ulnar bowing (HP:0003031)2.36586622
47Nuclear cataract (HP:0100018)2.35743520
48Myopathic facies (HP:0002058)2.34322989
49Oral leukoplakia (HP:0002745)2.33989936
50Distal lower limb amyotrophy (HP:0008944)2.33596645
51Aplastic anemia (HP:0001915)2.30287031
52Pointed chin (HP:0000307)2.28818345
53Patellar aplasia (HP:0006443)2.28542408
54Turricephaly (HP:0000262)2.27903115
55Cerebral hypomyelination (HP:0006808)2.27744588
56Cerebral inclusion bodies (HP:0100314)2.27607886
57Neurofibrillary tangles (HP:0002185)2.27375823
58Overriding aorta (HP:0002623)2.25657645
59Facial hemangioma (HP:0000329)2.25495442
60Insomnia (HP:0100785)2.24930249
61Ankyloglossia (HP:0010296)2.23600844
62Mitral regurgitation (HP:0001653)2.22758297
63Angiofibromas (HP:0010615)2.21607702
64Adenoma sebaceum (HP:0009720)2.21607702
65Prominent nose (HP:0000448)2.19374510
66Bronchomalacia (HP:0002780)2.19004290
67Elfin facies (HP:0004428)2.18833937
68Aplasia/Hypoplasia of the patella (HP:0006498)2.18369952
69Atresia of the external auditory canal (HP:0000413)2.15390150
70Skin tags (HP:0010609)2.14297100
71Disproportionate tall stature (HP:0001519)2.13829917
72Agnosia (HP:0010524)2.12043867
73Premature skin wrinkling (HP:0100678)2.11908140
74Exercise-induced myalgia (HP:0003738)2.11392650
75Bowel incontinence (HP:0002607)2.09858891
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.09843372
77Bowel diverticulosis (HP:0005222)2.07318665
78Hemorrhage of the eye (HP:0011885)2.06845500
79Vertebral compression fractures (HP:0002953)2.05718059
80Ankle clonus (HP:0011448)2.02671240
81Overlapping toe (HP:0001845)2.02408873
82Preauricular skin tag (HP:0000384)2.02337193
83Volvulus (HP:0002580)2.02247549
84Reticulocytosis (HP:0001923)2.00841003
85Cervical subluxation (HP:0003308)2.00284464
86Breast hypoplasia (HP:0003187)2.00001491
87Pseudobulbar signs (HP:0002200)1.99955719
88Broad palm (HP:0001169)1.99218957
89Spinal canal stenosis (HP:0003416)1.98999719
90Thin bony cortex (HP:0002753)1.98990563
91Absent radius (HP:0003974)1.97962780
92Megalocornea (HP:0000485)1.97802479
93Renovascular hypertension (HP:0100817)1.96506104
94High pitched voice (HP:0001620)1.94991635
95Neuronal loss in central nervous system (HP:0002529)1.94683245
96Increased connective tissue (HP:0009025)1.94629238
97Abnormal large intestine physiology (HP:0012700)1.92397955
98Absent thumb (HP:0009777)1.91432484
99Cafe-au-lait spot (HP:0000957)1.91262264
100Spinal muscular atrophy (HP:0007269)1.91010356
101Long eyelashes (HP:0000527)1.89908548
102Neoplasm of the pancreas (HP:0002894)1.89727555
103Urethral obstruction (HP:0000796)1.88746939
104Hand muscle atrophy (HP:0009130)1.88556937
105Trismus (HP:0000211)1.87504798
106Hyperthyroidism (HP:0000836)1.87014314
107Dysmetric saccades (HP:0000641)1.86659500
108Metaphyseal cupping (HP:0003021)1.86408980
109Myelodysplasia (HP:0002863)1.86225533
11011 pairs of ribs (HP:0000878)1.85037156
111Progressive muscle weakness (HP:0003323)1.84866076
112Atelectasis (HP:0100750)1.84835432
113Aplasia involving forearm bones (HP:0009822)1.84479936
114Absent forearm bone (HP:0003953)1.84479936
115Multiple enchondromatosis (HP:0005701)1.84320788
116Fibroma (HP:0010614)1.83192141
117Abnormality of the calcaneus (HP:0008364)1.82935179
118Abnormality of complement system (HP:0005339)1.82839932
119Growth hormone excess (HP:0000845)1.82030411
120Esophageal atresia (HP:0002032)1.81759807
121Distal upper limb amyotrophy (HP:0007149)1.81664256
122Upper limb amyotrophy (HP:0009129)1.81664256
123Abnormality of the thoracic spine (HP:0100711)1.81581654
124Abnormality of the fingertips (HP:0001211)1.81544205
125Increased variability in muscle fiber diameter (HP:0003557)1.81490988
126Ragged-red muscle fibers (HP:0003200)1.81407336
127Trigonocephaly (HP:0000243)1.81183733
128Lower limb amyotrophy (HP:0007210)1.80030088
129Amyotrophic lateral sclerosis (HP:0007354)1.79926957
130Abnormal neuron morphology (HP:0012757)1.79581091
131Abnormality of the motor neurons (HP:0002450)1.79581091
132Aplasia/hypoplasia of the humerus (HP:0006507)1.79114235
133Cerebral aneurysm (HP:0004944)1.78839941
134Broad alveolar ridges (HP:0000187)1.78783008
135Tracheoesophageal fistula (HP:0002575)1.78644651
136Seborrheic dermatitis (HP:0001051)1.77861913
137Acute lymphatic leukemia (HP:0006721)1.77552045
138Long palpebral fissure (HP:0000637)1.76846521
139Premature ovarian failure (HP:0008209)1.76839843
140Heterotopia (HP:0002282)1.76180132
141Hypercortisolism (HP:0001578)1.75695460
142Foot dorsiflexor weakness (HP:0009027)1.75450500
143Dysostosis multiplex (HP:0000943)1.75298670
144Genu recurvatum (HP:0002816)1.75143574
145Dislocated radial head (HP:0003083)1.74821681
146Amaurosis fugax (HP:0100576)1.74728573
147Abnormality of the salivary glands (HP:0010286)1.74505768
148Fibrous tissue neoplasm (HP:0012316)1.74384871
149Rib fusion (HP:0000902)1.74327150
150Pallor (HP:0000980)1.74244091
151Lymphangioma (HP:0100764)1.74111594
152Abdominal situs inversus (HP:0003363)1.73517075
153Abnormality of abdominal situs (HP:0011620)1.73517075
154Deformed sella turcica (HP:0002681)1.73057889
155High anterior hairline (HP:0009890)1.72924806
156Back pain (HP:0003418)1.72563297
157Gastrointestinal carcinoma (HP:0002672)1.71851608
158Malignant gastrointestinal tract tumors (HP:0006749)1.71851608
159Polygenic inheritance (HP:0010982)1.71040547
160Slender long bone (HP:0003100)1.70824113
161Pelvic girdle muscle weakness (HP:0003749)1.70423812
162Thin ribs (HP:0000883)1.69148307
163Vertebral arch anomaly (HP:0008438)1.68934774
164Hammertoe (HP:0001765)1.68497666
165Peripheral hypomyelination (HP:0007182)1.68454492
166Advanced eruption of teeth (HP:0006288)1.68326133
167Premature rupture of membranes (HP:0001788)1.67747946
168Neonatal death (HP:0003811)1.67191017
169Abnormality of oral frenula (HP:0000190)1.67107549
170Alacrima (HP:0000522)1.66929822
171Deep palmar crease (HP:0006191)1.63484703
172Mucopolysacchariduria (HP:0008155)1.62988866
173Urinary glycosaminoglycan excretion (HP:0003541)1.62988866
174Patellar dislocation (HP:0002999)1.60122102
175Complement deficiency (HP:0004431)1.59742489
176Broad distal phalanx of finger (HP:0009836)1.59674901
177Aplasia involving bones of the extremities (HP:0009825)1.59265277
178Aplasia involving bones of the upper limbs (HP:0009823)1.59265277
179Aplasia of the phalanges of the hand (HP:0009802)1.59265277
180Distal lower limb muscle weakness (HP:0009053)1.59211727
181Aneurysm (HP:0002617)1.57996903
182Asymmetry of the thorax (HP:0001555)1.57496774
183Abnormality of the radial head (HP:0003995)1.57207910
184Hypercholesterolemia (HP:0003124)1.56632890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.84008240
2EEF2K3.67507066
3BUB13.42144070
4CDK123.12652659
5WEE13.10802798
6SMG13.08088082
7MAP3K102.86658360
8SIK12.78527651
9PRPF4B2.78376530
10NEK22.77404705
11PKN22.65811938
12NEK12.40334486
13FGFR42.35523877
14TSSK62.30832419
15SCYL22.23480817
16TRIB32.21682237
17IRAK32.00922694
18MAP3K131.86060041
19ALK1.83868224
20CDK71.82760371
21TESK21.81237180
22RPS6KB21.79276130
23TTK1.71007201
24PASK1.64241346
25CDK41.60364381
26LATS21.55244718
27TNK21.53018485
28ICK1.51610331
29ATR1.46522504
30MAP3K81.43099066
31TGFBR11.42705747
32PLK11.42684701
33NTRK11.42524574
34PAK41.40943732
35PNCK1.39412512
36MARK21.36035209
37STK101.31185588
38MST1R1.31126717
39CHEK11.25178096
40MTOR1.22658178
41CHEK21.14957676
42NTRK31.14549505
43LRRK21.14506533
44TAOK11.12402349
45MAP3K91.10478662
46BRD41.10432822
47MAP4K11.09223824
48MAP2K61.06918694
49FGFR31.06846374
50DYRK31.05774000
51MAP3K111.04880964
52TYRO31.02959147
53CDK21.02377433
54AURKB1.02097027
55AURKA0.99991834
56EPHA20.99416962
57CAMKK10.98491844
58SRPK10.98278594
59MAPK110.97586418
60PDPK10.97420184
61CDC42BPA0.96321117
62PDGFRA0.96024295
63ARAF0.95601303
64MAPK120.94747403
65FLT30.92624513
66KSR20.92226175
67EIF2AK10.92169115
68MKNK10.90230657
69PAK20.89816921
70NME20.87176290
71CDK60.85331430
72PRKD20.83955467
73BRSK10.81876097
74DAPK10.81373938
75PTK20.78974403
76RIPK40.78742118
77PLK30.78534955
78GRK60.75943180
79FGFR10.75835018
80BMX0.75590228
81EPHB10.75178971
82PRKD30.75079054
83LMTK20.73517632
84PAK10.72524093
85ATM0.72296132
86RIPK10.72002809
87RPS6KA40.71820686
88MAP3K10.70744451
89IRAK20.70247937
90SIK20.68392395
91ERN10.66869199
92BRSK20.66734192
93CSNK1E0.65983700
94KDR0.65588004
95PDK10.65445353
96CDK10.64469511
97MET0.64208669
98KSR10.63821232
99AKT20.63491578
100RET0.62125121
101MAP2K20.62096177
102TAOK20.62091834
103HIPK20.62033904
104CDK190.61008106
105ACVR1B0.59893608
106RPS6KA20.59821121
107PAK60.57485917
108RAF10.57244171
109MAP3K60.57067305
110CSNK2A20.56746015
111EPHA40.56622179
112BRAF0.53891888
113NTRK20.53390189
114DDR20.52593544
115TYK20.50940024
116NME10.50419325
117UHMK10.50349920
118MAP2K30.49869541
119MAP3K20.49841103
120TTN0.48011505
121CDK90.47162451
122RPS6KL10.46665841
123RPS6KC10.46665841
124CDK11A0.45517847
125ZAP700.44469874
126MAPKAPK30.42547688
127JAK30.42437010
128ILK0.42374955
129STK380.42150455
130TBK10.41966818
131PTK60.41712131
132PRKDC0.41494475
133FGFR20.41285977
134CDK150.40936207
135CAMK1D0.40917518
136MAPK140.40319728
137RPS6KA10.40310885
138NEK60.40103566
139SGK30.38669806
140TESK10.38526334
141MAPK80.38308372
142CDK180.37266529
143WNK10.36091172
144VRK10.36040629
145MAPK100.35360358
146CSNK1D0.34738353
147GSK3B0.34415111
148PRKCI0.34205882
149MAPK90.34191880
150CDK140.34164285
151CDK80.33271742
152MATK0.30896312
153MAPK10.30427683
154MAP3K70.30372469

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66536302
2Mismatch repair_Homo sapiens_hsa034303.82242012
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44519648
4Spliceosome_Homo sapiens_hsa030403.37683229
5RNA transport_Homo sapiens_hsa030133.36765206
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.94909111
7Base excision repair_Homo sapiens_hsa034102.85622087
8Other glycan degradation_Homo sapiens_hsa005112.80462347
9One carbon pool by folate_Homo sapiens_hsa006702.55777009
10Ribosome_Homo sapiens_hsa030102.53837098
11Cell cycle_Homo sapiens_hsa041102.53270285
12Nucleotide excision repair_Homo sapiens_hsa034202.31234131
13mRNA surveillance pathway_Homo sapiens_hsa030152.26807134
14Homologous recombination_Homo sapiens_hsa034402.07178098
15RNA polymerase_Homo sapiens_hsa030201.98260070
16Prion diseases_Homo sapiens_hsa050201.91163951
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81878479
18RNA degradation_Homo sapiens_hsa030181.66683400
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.56254713
20Pyrimidine metabolism_Homo sapiens_hsa002401.54971774
21Non-homologous end-joining_Homo sapiens_hsa034501.47542824
22Oocyte meiosis_Homo sapiens_hsa041141.46161650
23Vitamin B6 metabolism_Homo sapiens_hsa007501.42495283
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42287376
25Proteasome_Homo sapiens_hsa030501.41693758
26GnRH signaling pathway_Homo sapiens_hsa049121.41445496
27Arginine biosynthesis_Homo sapiens_hsa002201.40974271
28Fanconi anemia pathway_Homo sapiens_hsa034601.37985516
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.31837906
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26503801
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25133691
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25074872
33Choline metabolism in cancer_Homo sapiens_hsa052311.22792854
34p53 signaling pathway_Homo sapiens_hsa041151.22598335
35Thyroid cancer_Homo sapiens_hsa052161.22457259
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21498990
37Biosynthesis of amino acids_Homo sapiens_hsa012301.20668142
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.13227286
39mTOR signaling pathway_Homo sapiens_hsa041501.11588339
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11458258
41Colorectal cancer_Homo sapiens_hsa052101.07601269
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06566631
43Chronic myeloid leukemia_Homo sapiens_hsa052201.06457402
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.05325746
45Inositol phosphate metabolism_Homo sapiens_hsa005621.04938283
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04113760
47Epstein-Barr virus infection_Homo sapiens_hsa051691.03845146
48MicroRNAs in cancer_Homo sapiens_hsa052061.03444483
49* Notch signaling pathway_Homo sapiens_hsa043301.01922986
50Glucagon signaling pathway_Homo sapiens_hsa049221.00239944
51Bile secretion_Homo sapiens_hsa049760.99937036
52* HTLV-I infection_Homo sapiens_hsa051660.99298229
53Basal cell carcinoma_Homo sapiens_hsa052170.98051623
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97980887
55Synaptic vesicle cycle_Homo sapiens_hsa047210.97711764
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96174105
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93252498
58Non-small cell lung cancer_Homo sapiens_hsa052230.92489768
59Hippo signaling pathway_Homo sapiens_hsa043900.92119750
60Basal transcription factors_Homo sapiens_hsa030220.90851821
61* Viral carcinogenesis_Homo sapiens_hsa052030.90270277
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87398389
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86388463
64Bladder cancer_Homo sapiens_hsa052190.86289534
65Antigen processing and presentation_Homo sapiens_hsa046120.84326886
66Thyroid hormone synthesis_Homo sapiens_hsa049180.82114162
67Acute myeloid leukemia_Homo sapiens_hsa052210.79459428
68Pentose phosphate pathway_Homo sapiens_hsa000300.77649187
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.77541893
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75917728
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.75617857
72Melanogenesis_Homo sapiens_hsa049160.73883885
73Gastric acid secretion_Homo sapiens_hsa049710.73218406
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73143665
75Herpes simplex infection_Homo sapiens_hsa051680.73019970
76Focal adhesion_Homo sapiens_hsa045100.72782549
77Hedgehog signaling pathway_Homo sapiens_hsa043400.72629980
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72175245
79Small cell lung cancer_Homo sapiens_hsa052220.71488365
80* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71249730
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71133571
82Complement and coagulation cascades_Homo sapiens_hsa046100.70746340
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70241800
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.69066204
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68876831
86Purine metabolism_Homo sapiens_hsa002300.68518814
87Glioma_Homo sapiens_hsa052140.66936684
88Prolactin signaling pathway_Homo sapiens_hsa049170.66366176
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.65098727
90VEGF signaling pathway_Homo sapiens_hsa043700.64879157
91Arginine and proline metabolism_Homo sapiens_hsa003300.64419484
92HIF-1 signaling pathway_Homo sapiens_hsa040660.63761706
93Insulin resistance_Homo sapiens_hsa049310.63211574
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63136790
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63049038
96Wnt signaling pathway_Homo sapiens_hsa043100.62832913
97Lysine degradation_Homo sapiens_hsa003100.62571067
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61961446
99Endometrial cancer_Homo sapiens_hsa052130.61789715
100Endocytosis_Homo sapiens_hsa041440.60148008
101Insulin secretion_Homo sapiens_hsa049110.60124593
102Prostate cancer_Homo sapiens_hsa052150.59608410
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59175435
104Proteoglycans in cancer_Homo sapiens_hsa052050.56628058
105ECM-receptor interaction_Homo sapiens_hsa045120.56289309
106Shigellosis_Homo sapiens_hsa051310.55700311
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.55610421
108Pathways in cancer_Homo sapiens_hsa052000.55291448
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54348393
110N-Glycan biosynthesis_Homo sapiens_hsa005100.54128178
111TGF-beta signaling pathway_Homo sapiens_hsa043500.53773057
112Amoebiasis_Homo sapiens_hsa051460.53525016
113Phenylalanine metabolism_Homo sapiens_hsa003600.53446341
114Selenocompound metabolism_Homo sapiens_hsa004500.52383455
115Amphetamine addiction_Homo sapiens_hsa050310.52169222
116Estrogen signaling pathway_Homo sapiens_hsa049150.52111622
117Adherens junction_Homo sapiens_hsa045200.52099630
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51510756
119Hepatitis C_Homo sapiens_hsa051600.51481362
120MAPK signaling pathway_Homo sapiens_hsa040100.51187122
121B cell receptor signaling pathway_Homo sapiens_hsa046620.48918216
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48798399
123Carbon metabolism_Homo sapiens_hsa012000.48051994
124Fatty acid biosynthesis_Homo sapiens_hsa000610.45363246
125Hepatitis B_Homo sapiens_hsa051610.45278399
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44894871
127Sulfur relay system_Homo sapiens_hsa041220.44808035
128Renal cell carcinoma_Homo sapiens_hsa052110.44317799
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43428676
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40914041
131Gap junction_Homo sapiens_hsa045400.40808519
132Galactose metabolism_Homo sapiens_hsa000520.40806065
133Apoptosis_Homo sapiens_hsa042100.39287544
134Viral myocarditis_Homo sapiens_hsa054160.38168709
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36677673
136Pancreatic cancer_Homo sapiens_hsa052120.35930876
137Insulin signaling pathway_Homo sapiens_hsa049100.35719865
138Tight junction_Homo sapiens_hsa045300.35127125
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35092272
140Alcoholism_Homo sapiens_hsa050340.34472889
141ErbB signaling pathway_Homo sapiens_hsa040120.32625782
142Long-term potentiation_Homo sapiens_hsa047200.32512752
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31760055
144Dorso-ventral axis formation_Homo sapiens_hsa043200.31686850
145AMPK signaling pathway_Homo sapiens_hsa041520.29870048
146T cell receptor signaling pathway_Homo sapiens_hsa046600.29799213
147Fructose and mannose metabolism_Homo sapiens_hsa000510.29760402
148Rap1 signaling pathway_Homo sapiens_hsa040150.29284640
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27852210

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »