KAT2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.47896970
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.47896970
3L-phenylalanine metabolic process (GO:0006558)6.08723112
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.08723112
5aromatic amino acid family catabolic process (GO:0009074)5.26530041
6alpha-linolenic acid metabolic process (GO:0036109)5.07799776
7positive regulation of gamma-delta T cell activation (GO:0046645)4.99659075
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.76907004
9negative regulation of cell killing (GO:0031342)4.76907004
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.71494717
11bile acid biosynthetic process (GO:0006699)4.70096761
12glyoxylate metabolic process (GO:0046487)4.62898524
13cysteine metabolic process (GO:0006534)4.60123847
14sulfur amino acid catabolic process (GO:0000098)4.55262245
15complement activation, alternative pathway (GO:0006957)4.44635492
16fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.43317645
17kynurenine metabolic process (GO:0070189)4.37192941
18indole-containing compound catabolic process (GO:0042436)4.27092526
19indolalkylamine catabolic process (GO:0046218)4.27092526
20tryptophan catabolic process (GO:0006569)4.27092526
21peptidyl-glutamic acid carboxylation (GO:0017187)4.23901421
22protein carboxylation (GO:0018214)4.23901421
23lysine metabolic process (GO:0006553)4.23399806
24lysine catabolic process (GO:0006554)4.23399806
25regulation of B cell receptor signaling pathway (GO:0050855)4.23267984
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.18761281
27regulation of triglyceride catabolic process (GO:0010896)4.14535174
28bile acid metabolic process (GO:0008206)4.07926984
29regulation of protein activation cascade (GO:2000257)4.07080732
30homocysteine metabolic process (GO:0050667)4.07076768
31tryptophan metabolic process (GO:0006568)4.06278902
32short-chain fatty acid metabolic process (GO:0046459)4.05554919
33urea cycle (GO:0000050)4.03008969
34urea metabolic process (GO:0019627)4.03008969
35fatty acid beta-oxidation (GO:0006635)3.96583427
36high-density lipoprotein particle remodeling (GO:0034375)3.95403285
37ethanol oxidation (GO:0006069)3.95150648
38negative regulation of fibrinolysis (GO:0051918)3.93697842
39regulation of gamma-delta T cell activation (GO:0046643)3.92313133
40coenzyme catabolic process (GO:0009109)3.90898132
41acetyl-CoA metabolic process (GO:0006084)3.88245030
42plasma lipoprotein particle clearance (GO:0034381)3.87818091
43tyrosine metabolic process (GO:0006570)3.86339877
44regulation of complement activation (GO:0030449)3.86338679
45fatty acid oxidation (GO:0019395)3.82143913
46regulation of gamma-delta T cell differentiation (GO:0045586)3.80530584
47amino-acid betaine metabolic process (GO:0006577)3.79795372
48serine family amino acid catabolic process (GO:0009071)3.79445513
49valine metabolic process (GO:0006573)3.79355160
50regulation of fibrinolysis (GO:0051917)3.76994255
51alpha-amino acid catabolic process (GO:1901606)3.76194181
52phospholipid homeostasis (GO:0055091)3.75176441
53lipid oxidation (GO:0034440)3.75086381
54aromatic amino acid family metabolic process (GO:0009072)3.73593095
55aspartate family amino acid catabolic process (GO:0009068)3.71168292
56fatty acid catabolic process (GO:0009062)3.70547491
57acylglycerol homeostasis (GO:0055090)3.70335335
58triglyceride homeostasis (GO:0070328)3.70335335
59nitrogen cycle metabolic process (GO:0071941)3.69501066
60regulation of cholesterol metabolic process (GO:0090181)3.64656505
61microglial cell activation (GO:0001774)3.64239610
622-oxoglutarate metabolic process (GO:0006103)3.62196577
63cellular amino acid catabolic process (GO:0009063)3.61090994
64regulation of cholesterol biosynthetic process (GO:0045540)3.58391683
65reverse cholesterol transport (GO:0043691)3.55528724
66cellular ketone body metabolic process (GO:0046950)3.54946792
67glutamate metabolic process (GO:0006536)3.52413922
68monocarboxylic acid catabolic process (GO:0072329)3.49409417
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48927261
70detection of other organism (GO:0098543)3.47566898
71cellular modified amino acid catabolic process (GO:0042219)3.46774847
72fatty acid transmembrane transport (GO:1902001)3.46263682
73plasma lipoprotein particle remodeling (GO:0034369)3.43585248
74protein-lipid complex remodeling (GO:0034368)3.43585248
75macromolecular complex remodeling (GO:0034367)3.43585248
76negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42737961
77positive regulation of fatty acid beta-oxidation (GO:0032000)3.40949099
78very long-chain fatty acid metabolic process (GO:0000038)3.39996236
79cholesterol efflux (GO:0033344)3.39566048
80positive regulation by organism of defense response of other organism involved in symbiotic interact3.38359851
81modulation by symbiont of host immune response (GO:0052553)3.38359851
82positive regulation by symbiont of host defense response (GO:0052509)3.38359851
83modulation by symbiont of host defense response (GO:0052031)3.38359851
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38359851
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38359851
86branched-chain amino acid catabolic process (GO:0009083)3.38021146
87heme transport (GO:0015886)3.36649170
88organic acid catabolic process (GO:0016054)3.36166510
89carboxylic acid catabolic process (GO:0046395)3.36166510
90cellular response to epinephrine stimulus (GO:0071872)3.35199214
91detection of molecule of bacterial origin (GO:0032490)3.34645693
92phospholipid efflux (GO:0033700)3.33516556
93negative regulation of T cell mediated immunity (GO:0002710)3.33489198
94acyl-CoA biosynthetic process (GO:0071616)3.32942900
95thioester biosynthetic process (GO:0035384)3.32942900
96cholesterol homeostasis (GO:0042632)3.32692071
97regulation of cholesterol homeostasis (GO:2000188)3.31843406
98dicarboxylic acid biosynthetic process (GO:0043650)3.31622361
99regulation of cholesterol esterification (GO:0010872)3.31121748
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30757794
101antigen processing and presentation of endogenous antigen (GO:0019883)3.29907150
102sterol homeostasis (GO:0055092)3.28657742
103bile acid and bile salt transport (GO:0015721)3.28136072
104cellular glucuronidation (GO:0052695)3.28126984
105branched-chain amino acid metabolic process (GO:0009081)3.28090820
106fatty-acyl-CoA biosynthetic process (GO:0046949)3.27573871
107cofactor catabolic process (GO:0051187)3.27257620
108positive regulation of lipid catabolic process (GO:0050996)3.26871708
109activated T cell proliferation (GO:0050798)3.26636184
110negative T cell selection (GO:0043383)3.24014979
111macrophage activation involved in immune response (GO:0002281)3.22683684
112positive thymic T cell selection (GO:0045059)3.22539374
113regulation of sequestering of triglyceride (GO:0010889)3.22492909
114negative regulation of erythrocyte differentiation (GO:0045647)3.22077334
115positive T cell selection (GO:0043368)3.21929429
116negative regulation of cholesterol transport (GO:0032375)3.20656531
117negative regulation of sterol transport (GO:0032372)3.20656531
118detection of bacterium (GO:0016045)3.20634205
119negative regulation of lymphocyte mediated immunity (GO:0002707)3.19438004
120drug transmembrane transport (GO:0006855)3.19359454
121negative thymic T cell selection (GO:0045060)3.18592238
122creatine metabolic process (GO:0006600)3.17629350
123positive regulation of cellular amide metabolic process (GO:0034250)3.15975832
124ketone body metabolic process (GO:1902224)3.15260421
125antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15234198
126response to interleukin-15 (GO:0070672)3.14653912
127serine family amino acid metabolic process (GO:0009069)3.14509562
128biotin metabolic process (GO:0006768)3.14072583
129fatty acid elongation (GO:0030497)3.11836820
130negative regulation of lipase activity (GO:0060192)3.09275580
131detection of external biotic stimulus (GO:0098581)3.09107048
132ethanol metabolic process (GO:0006067)3.08942404
133carnitine shuttle (GO:0006853)3.08506734
134positive regulation of triglyceride lipase activity (GO:0061365)3.08371408
135positive regulation of lipoprotein lipase activity (GO:0051006)3.08371408
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02762200
137neutrophil activation involved in immune response (GO:0002283)3.02679041
138B cell receptor signaling pathway (GO:0050853)2.97956138
139cellular extravasation (GO:0045123)2.96443933
140response to epinephrine (GO:0071871)2.93035342
141macrophage activation (GO:0042116)2.90092526
142cellular response to interleukin-15 (GO:0071350)2.85403949
143regulation of platelet aggregation (GO:0090330)2.84128635
144positive regulation of Rap GTPase activity (GO:0032854)2.81819986
145regulation of beta-amyloid formation (GO:1902003)2.79012724
146regulation of relaxation of muscle (GO:1901077)2.78247674
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.76775381
148T cell selection (GO:0045058)2.75582474
149negative regulation of leukocyte mediated immunity (GO:0002704)2.74470719
150gas transport (GO:0015669)2.72368226
151leukocyte aggregation (GO:0070486)2.71298397
152response to methylmercury (GO:0051597)2.70624740
153regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.68016035
154positive regulation of granulocyte differentiation (GO:0030854)2.67116537
155sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65522871
156oxygen transport (GO:0015671)2.64317991
157detection of biotic stimulus (GO:0009595)2.58179206
158neutrophil activation (GO:0042119)2.56078304
159regulation of necroptotic process (GO:0060544)2.56004361
160thymic T cell selection (GO:0045061)2.54358491
161T cell migration (GO:0072678)2.54283450
162negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.51953386
163nerve growth factor signaling pathway (GO:0038180)2.45965615
164protoporphyrinogen IX metabolic process (GO:0046501)2.45918625
165negative regulation of interleukin-12 production (GO:0032695)2.45671809
166skeletal muscle adaptation (GO:0043501)2.45611693
167regulation of Rap GTPase activity (GO:0032317)2.43248126
168macroautophagy (GO:0016236)2.42210778
169hepatocyte apoptotic process (GO:0097284)2.40631365
170response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40533846
171response to host immune response (GO:0052572)2.40533846
172myeloid cell development (GO:0061515)2.40149648
173granulocyte activation (GO:0036230)2.39514093
174positive regulation of B cell differentiation (GO:0045579)2.38982389
175regulation of amyloid precursor protein catabolic process (GO:1902991)2.37566859
176negative regulation of neurotransmitter transport (GO:0051589)2.37184815
177myeloid cell activation involved in immune response (GO:0002275)2.36688052
178antigen processing and presentation via MHC class Ib (GO:0002475)2.36671677
179hemoglobin metabolic process (GO:0020027)2.34598979
180megakaryocyte development (GO:0035855)2.34264070
181erythrocyte development (GO:0048821)2.33137832
182regulation of cellular amide metabolic process (GO:0034248)2.32049608
183negative regulation of adaptive immune response (GO:0002820)2.31985233
184regulation of interferon-beta biosynthetic process (GO:0045357)2.31959805
185actin-myosin filament sliding (GO:0033275)2.31773041
186muscle filament sliding (GO:0030049)2.31773041
187response to peptidoglycan (GO:0032494)2.31231902
188negative regulation of cAMP-mediated signaling (GO:0043951)2.30608766
189negative regulation of immunoglobulin mediated immune response (GO:0002890)2.28562837
190negative regulation of B cell mediated immunity (GO:0002713)2.28562837
191regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.27130316
192cellular response to ethanol (GO:0071361)2.26468411
193response to muramyl dipeptide (GO:0032495)2.26362022
194positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.25713783
195negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.25535332
196neutrophil mediated immunity (GO:0002446)2.25102229
197positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.24836386
198production of molecular mediator involved in inflammatory response (GO:0002532)2.24053484
199regulation of B cell differentiation (GO:0045577)2.23604575
200response to host defenses (GO:0052200)2.20792694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.48867018
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.20856207
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.42458639
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.31474879
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.80072144
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74057905
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33206851
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09918839
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.75032595
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43457911
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.18644348
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.80112896
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.73253993
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58382444
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39224275
16SCL_19346495_ChIP-Seq_HPC-7_Human2.36922357
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.31595428
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27897177
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.24177609
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.22222486
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15652686
22CLOCK_20551151_ChIP-Seq_293T_Human2.11978622
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.95981005
24GATA1_22025678_ChIP-Seq_K562_Human1.92849678
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.92051610
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.80149292
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72442200
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70798035
29SPI1_23127762_ChIP-Seq_K562_Human1.68958157
30MYB_26560356_Chip-Seq_TH2_Human1.67337467
31* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64869391
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61985929
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59632894
34VDR_24787735_ChIP-Seq_THP-1_Human1.59174611
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.54246326
36* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52779718
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.52705300
38* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48248665
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46042781
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.42667842
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40836995
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.40489646
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35784716
44KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.32183654
45* GATA3_27048872_Chip-Seq_THYMUS_Human1.32098013
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.28066122
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27627682
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27297295
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27266775
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25853192
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25325736
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25325736
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22802295
54MYB_26560356_Chip-Seq_TH1_Human1.22194305
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.21314753
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20267195
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20253632
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.19702913
59TCF7_22412390_ChIP-Seq_EML_Mouse1.19128272
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.18765748
61ZNF263_19887448_ChIP-Seq_K562_Human1.18722370
62* TBX20_22080862_ChIP-Seq_HEART_Mouse1.18097728
63* TBX20_22328084_ChIP-Seq_HEART_Mouse1.18097728
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17276971
65* MAF_26560356_Chip-Seq_TH1_Human1.17257215
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.17025198
67GATA1_19941826_ChIP-Seq_K562_Human1.16339571
68FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15965274
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.12775589
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12730555
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12295213
72VDR_24763502_ChIP-Seq_THP-1_Human1.11818203
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11467886
74EZH2_22144423_ChIP-Seq_EOC_Human1.10937779
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10924864
76PU_27001747_Chip-Seq_BMDM_Mouse1.09091723
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09068658
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08803493
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08795101
80DROSHA_22980978_ChIP-Seq_HELA_Human1.07821796
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.07325293
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06388148
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.06104762
84GATA4_25053715_ChIP-Seq_YYC3_Human1.06022137
85GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05835770
86* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04880897
87* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04241140
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04202713
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04087912
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.03095053
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02183178
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02166701
93HTT_18923047_ChIP-ChIP_STHdh_Human0.99574906
94KDM2B_26808549_Chip-Seq_DND41_Human0.98949031
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98731278
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98196810
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96717845
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92160622
99GATA3_26560356_Chip-Seq_TH2_Human0.90707354
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90536057
101UTX_26944678_Chip-Seq_JUKART_Human0.89160605
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89083025
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88314904
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88055416
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88039709
106SPI1_23547873_ChIP-Seq_NB4_Human0.87942116
107AR_21572438_ChIP-Seq_LNCaP_Human0.87789810
108GATA2_19941826_ChIP-Seq_K562_Human0.87203665
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86980733
110TRIM28_21343339_ChIP-Seq_HEK293_Human0.86978747
111* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86759702
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86737918
113GBX2_23144817_ChIP-Seq_PC3_Human0.85683920
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.83884766
115* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83728657
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.83456381
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82799745
118* SMRT_27268052_Chip-Seq_Bcells_Human0.82342758
119OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82154727
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81517317
121TP53_16413492_ChIP-PET_HCT116_Human0.81178689
122* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80863820
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.80714673
124* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80074301
125SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78472827
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.78365963
127SOX2_20726797_ChIP-Seq_SW620_Human0.78101478
128* GATA3_24758297_ChIP-Seq_MCF-7_Human0.77494787
129* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76851543
130* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.76095456
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76074124
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75232056
133ER_23166858_ChIP-Seq_MCF-7_Human0.74977495
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.74600440
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74186269
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74071965
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73589311
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73395436
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72812223
140* GATA6_25053715_ChIP-Seq_YYC3_Human0.72390824
141* CJUN_26792858_Chip-Seq_BT549_Human0.71602042
142RUNX_20019798_ChIP-Seq_JUKART_Human0.71485931
143CBP_21632823_ChIP-Seq_H3396_Human0.71378869
144* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70783936
145* TP63_23658742_ChIP-Seq_EP156T_Human0.70534264
146* CDX2_22108803_ChIP-Seq_LS180_Human0.70219491
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69061167
148GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.67907256
149ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.67436651
150* CEBPB_22108803_ChIP-Seq_LS180_Human0.67228741
151* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.67214173
152EGR1_19032775_ChIP-ChIP_M12_Human0.65330022
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.64357842
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.63992567
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.63032949
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.63006208
157NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62756656
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.61292327
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.61166177
160RXRA_24833708_ChIP-Seq_LIVER_Mouse0.59939181
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59843088
162ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.59094096
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58116473
164CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.57280583
165SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.56988002
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56054850
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54766579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.49123528
2MP0005360_urolithiasis5.80848044
3MP0005085_abnormal_gallbladder_physiolo4.97592045
4MP0005365_abnormal_bile_salt4.93614382
5MP0003806_abnormal_nucleotide_metabolis4.09599918
6MP0008875_abnormal_xenobiotic_pharmacok3.99968075
7MP0003252_abnormal_bile_duct3.42730975
8MP0003303_peritoneal_inflammation2.91888167
9MP0010329_abnormal_lipoprotein_level2.88388719
10MP0003195_calcinosis2.85571545
11MP0005083_abnormal_biliary_tract2.77988692
12MP0009840_abnormal_foam_cell2.75795546
13MP0000569_abnormal_digit_pigmentation2.60705397
14MP0005332_abnormal_amino_acid2.43769398
15MP0001835_abnormal_antigen_presentation2.35035498
16MP0001666_abnormal_nutrient_absorption2.29618727
17MP0008260_abnormal_autophagy2.28521040
18MP0003191_abnormal_cellular_cholesterol2.28430113
19MP0003763_abnormal_thymus_physiology2.23363933
20MP0003436_decreased_susceptibility_to2.22590494
21MP0002118_abnormal_lipid_homeostasis2.13301017
22MP0001800_abnormal_humoral_immune2.03433660
23MP0004130_abnormal_muscle_cell1.99277201
24MP0000609_abnormal_liver_physiology1.91988591
25MP0003183_abnormal_peptide_metabolism1.90688065
26MP0002419_abnormal_innate_immunity1.85538372
27MP0005000_abnormal_immune_tolerance1.84698092
28MP0005464_abnormal_platelet_physiology1.84565209
29MP0005671_abnormal_response_to1.84461028
30MP0000685_abnormal_immune_system1.82863195
31MP0003646_muscle_fatigue1.78861163
32MP0005025_abnormal_response_to1.75635151
33MP0005387_immune_system_phenotype1.71291104
34MP0001790_abnormal_immune_system1.71291104
35MP0003172_abnormal_lysosome_physiology1.70397061
36MP0009785_altered_susceptibility_to1.69795333
37MP0002138_abnormal_hepatobiliary_system1.69383374
38MP0002723_abnormal_immune_serum1.65790896
39MP0002837_dystrophic_cardiac_calcinosis1.64721049
40MP0002420_abnormal_adaptive_immunity1.63751738
41MP0003950_abnormal_plasma_membrane1.63041389
42MP0003828_pulmonary_edema1.61202670
43MP0004484_altered_response_of1.60023084
44MP0001819_abnormal_immune_cell1.59933705
45MP0005319_abnormal_enzyme/_coenzyme1.59306855
46MP0002452_abnormal_antigen_presenting1.55331944
47MP0004043_abnormal_pH_regulation1.53919804
48MP0003690_abnormal_glial_cell1.53749501
49MP0005670_abnormal_white_adipose1.52432858
50MP0004019_abnormal_vitamin_homeostasis1.51495866
51MP0005584_abnormal_enzyme/coenzyme_acti1.48903468
52MP0005666_abnormal_adipose_tissue1.48406913
53MP0003656_abnormal_erythrocyte_physiolo1.46435514
54MP0003705_abnormal_hypodermis_morpholog1.43384009
55MP0002398_abnormal_bone_marrow1.42262082
56MP0000465_gastrointestinal_hemorrhage1.41882321
57MP0003868_abnormal_feces_composition1.41191547
58MP0009643_abnormal_urine_homeostasis1.37431404
59MP0006082_CNS_inflammation1.37394007
60MP0004185_abnormal_adipocyte_glucose1.32080915
61MP0001851_eye_inflammation1.29806535
62MP0000015_abnormal_ear_pigmentation1.29476543
63MP0002009_preneoplasia1.29171625
64MP0000920_abnormal_myelination1.25790584
65MP0000716_abnormal_immune_system1.25438341
66MP0004947_skin_inflammation1.24770052
67MP0003866_abnormal_defecation1.23077231
68MP0005058_abnormal_lysosome_morphology1.21414015
69MP0004036_abnormal_muscle_relaxation1.21131663
70MP0002405_respiratory_system_inflammati1.20878844
71MP0002148_abnormal_hypersensitivity_rea1.20766160
72MP0001764_abnormal_homeostasis1.18115594
73MP0009278_abnormal_bone_marrow1.17384641
74MP0005408_hypopigmentation1.17054726
75MP0002971_abnormal_brown_adipose1.16933726
76MP0003186_abnormal_redox_activity1.16397011
77MP0003011_delayed_dark_adaptation1.16081076
78MP0001533_abnormal_skeleton_physiology1.15400692
79MP0000689_abnormal_spleen_morphology1.15318959
80MP0010234_abnormal_vibrissa_follicle1.15261910
81MP0005397_hematopoietic_system_phenotyp1.14587138
82MP0001545_abnormal_hematopoietic_system1.14587138
83MP0005451_abnormal_body_composition1.12899849
84MP0010155_abnormal_intestine_physiology1.09779460
85MP0002722_abnormal_immune_system1.08204819
86MP0001845_abnormal_inflammatory_respons1.07707269
87MP0005330_cardiomyopathy1.07344655
88MP0000703_abnormal_thymus_morphology1.06639376
89MP0000604_amyloidosis1.06029954
90MP0005375_adipose_tissue_phenotype1.04382405
91MP0000749_muscle_degeneration1.03820558
92MP0003300_gastrointestinal_ulcer1.02619866
93MP0003787_abnormal_imprinting1.02602613
94MP0008569_lethality_at_weaning1.01111706
95MP0003075_altered_response_to1.00467876
96MP0004883_abnormal_blood_vessel1.00367163
97MP0008874_decreased_physiological_sensi0.98939198
98MP0004215_abnormal_myocardial_fiber0.98836615
99MP0008004_abnormal_stomach_pH0.98750443
100MP0006036_abnormal_mitochondrial_physio0.98040039
101MP0005166_decreased_susceptibility_to0.96766713
102MP0001661_extended_life_span0.96260421
103MP0009697_abnormal_copulation0.96247955
104MP0005310_abnormal_salivary_gland0.95788230
105MP0005174_abnormal_tail_pigmentation0.95415045
106MP0002429_abnormal_blood_cell0.95091597
107MP0000598_abnormal_liver_morphology0.95072540
108MP0003221_abnormal_cardiomyocyte_apopto0.94239977
109MP0004084_abnormal_cardiac_muscle0.92659320
110MP0005647_abnormal_sex_gland0.92656256
111MP0004147_increased_porphyrin_level0.92254869
112MP0009763_increased_sensitivity_to0.91572261
113MP0002998_abnormal_bone_remodeling0.90578788
114MP0002078_abnormal_glucose_homeostasis0.89897073
115MP0002269_muscular_atrophy0.89226757
116MP0000751_myopathy0.86573283
117MP0000747_muscle_weakness0.86347381
118MP0010678_abnormal_skin_adnexa0.86225290
119MP0005334_abnormal_fat_pad0.85051471
120MP0002106_abnormal_muscle_physiology0.82887674
121MP0009764_decreased_sensitivity_to0.82786106
122MP0008438_abnormal_cutaneous_collagen0.82595808
123MP0005075_abnormal_melanosome_morpholog0.81013369
124MP0000249_abnormal_blood_vessel0.80414517
125MP0002396_abnormal_hematopoietic_system0.79889307
126MP0004510_myositis0.79825881
127MP0005167_abnormal_blood-brain_barrier0.79484241
128MP0009333_abnormal_splenocyte_physiolog0.79469236
129MP0003879_abnormal_hair_cell0.79177764
130MP0004087_abnormal_muscle_fiber0.78516908
131MP0000343_altered_response_to0.78024738
132MP0006138_congestive_heart_failure0.77833089
133MP0005636_abnormal_mineral_homeostasis0.77592319
134MP0010368_abnormal_lymphatic_system0.76826658
135MP0003091_abnormal_cell_migration0.76688334
136MP0000759_abnormal_skeletal_muscle0.76418556
137MP0004381_abnormal_hair_follicle0.75655900
138MP0003329_amyloid_beta_deposits0.74557438
139MP0002877_abnormal_melanocyte_morpholog0.73229899
140MP0009765_abnormal_xenobiotic_induced0.72064923
141MP0008775_abnormal_heart_ventricle0.71167584
142MP0001756_abnormal_urination0.71137530
143MP0000003_abnormal_adipose_tissue0.70767579
144MP0002166_altered_tumor_susceptibility0.70496699
145MP0002254_reproductive_system_inflammat0.70413886
146MP0005535_abnormal_body_temperature0.68667250
147MP0003453_abnormal_keratinocyte_physiol0.67922056
148MP0008469_abnormal_protein_level0.67466689
149MP0009642_abnormal_blood_homeostasis0.66971233
150MP0005266_abnormal_metabolism0.65591971
151MP0002332_abnormal_exercise_endurance0.62722547
152MP0005376_homeostasis/metabolism_phenot0.62150005
153MP0005220_abnormal_exocrine_pancreas0.59544764
154MP0002796_impaired_skin_barrier0.59497827
155MP0003724_increased_susceptibility_to0.56933322
156MP0010630_abnormal_cardiac_muscle0.56492056
157MP0002168_other_aberrant_phenotype0.55303902
158MP0005620_abnormal_muscle_contractility0.55046140
159MP0002090_abnormal_vision0.53050064
160MP0009780_abnormal_chondrocyte_physiolo0.52234000
161MP0002136_abnormal_kidney_physiology0.51111390
162MP0004885_abnormal_endolymph0.50672138
163MP0000230_abnormal_systemic_arterial0.50633016
164MP0000383_abnormal_hair_follicle0.50030685
165MP0002972_abnormal_cardiac_muscle0.49915628
166MP0004145_abnormal_muscle_electrophysio0.48012411
167MP0003045_fibrosis0.47684838
168MP0002060_abnormal_skin_morphology0.47489351
169MP0001765_abnormal_ion_homeostasis0.46956729
170MP0001544_abnormal_cardiovascular_syste0.46845351

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.42179916
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.89508572
3Deep venous thrombosis (HP:0002625)5.61068417
4Xanthomatosis (HP:0000991)5.43706828
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.99130438
6Hyperlipoproteinemia (HP:0010980)4.84043169
7Complement deficiency (HP:0004431)4.51189492
8Prolonged partial thromboplastin time (HP:0003645)4.35078461
9Hypoglycemic coma (HP:0001325)4.34533869
10Eczematoid dermatitis (HP:0000976)4.33198755
11Ketosis (HP:0001946)4.25255406
12Hypobetalipoproteinemia (HP:0003563)4.17354075
13Hyperammonemia (HP:0001987)4.14055650
14Epidermoid cyst (HP:0200040)4.06718462
15Abnormality of serine family amino acid metabolism (HP:0010894)3.99402865
16Abnormality of glycine metabolism (HP:0010895)3.99402865
17Hyperglycinemia (HP:0002154)3.89280589
18Hyperglycinuria (HP:0003108)3.84692856
19Hypoalphalipoproteinemia (HP:0003233)3.79817439
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73308385
21Hypolipoproteinemia (HP:0010981)3.72495449
22Poikilocytosis (HP:0004447)3.66758696
23Abnormality of fatty-acid metabolism (HP:0004359)3.64026364
24Recurrent bacterial skin infections (HP:0005406)3.58527518
25Abnormality of the common coagulation pathway (HP:0010990)3.57131451
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.54250828
27Fat malabsorption (HP:0002630)3.50348103
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.47663556
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.47511981
30Ketoacidosis (HP:0001993)3.44434908
31Abnormality of methionine metabolism (HP:0010901)3.44017948
32Myositis (HP:0100614)3.40787036
33Retrobulbar optic neuritis (HP:0100654)3.38258842
34Optic neuritis (HP:0100653)3.38258842
35Orchitis (HP:0100796)3.36713792
36Recurrent abscess formation (HP:0002722)3.36231780
37Muscle fiber inclusion bodies (HP:0100299)3.35330933
38T lymphocytopenia (HP:0005403)3.35196895
39Joint hemorrhage (HP:0005261)3.29224268
40Spontaneous hematomas (HP:0007420)3.23359670
41Nemaline bodies (HP:0003798)3.19632615
42Abnormality of the intrinsic pathway (HP:0010989)3.19554555
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17975060
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.16979806
45Abnormality of T cell number (HP:0011839)3.16729329
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.16603667
47Gastrointestinal infarctions (HP:0005244)3.15245069
48Hypercholesterolemia (HP:0003124)3.11597674
49Abnormality of complement system (HP:0005339)3.11430584
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.99520493
51Conjugated hyperbilirubinemia (HP:0002908)2.93906907
52Prolonged bleeding time (HP:0003010)2.92323032
53Myocardial infarction (HP:0001658)2.87421565
54Recurrent gram-negative bacterial infections (HP:0005420)2.85967130
55Papilledema (HP:0001085)2.82330953
56Skin nodule (HP:0200036)2.82108787
57Stomatitis (HP:0010280)2.81235293
58Hyperinsulinemic hypoglycemia (HP:0000825)2.77014554
59Keratoconjunctivitis sicca (HP:0001097)2.76255601
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76225097
61Dicarboxylic aciduria (HP:0003215)2.76225097
62Hyporeflexia of lower limbs (HP:0002600)2.74138330
63Myoglobinuria (HP:0002913)2.71809871
64Hypoglycemic seizures (HP:0002173)2.70570585
65Steatorrhea (HP:0002570)2.70474684
66Muscle hypertrophy of the lower extremities (HP:0008968)2.67883888
67Hyperbilirubinemia (HP:0002904)2.66509526
68Vasculitis (HP:0002633)2.65072492
69Abnormal gallbladder morphology (HP:0012437)2.61533154
70Recurrent fungal infections (HP:0002841)2.60326192
71Abnormality of macrophages (HP:0004311)2.59766038
72Calf muscle hypertrophy (HP:0008981)2.59524300
73Abnormality of purine metabolism (HP:0004352)2.59511268
74Subaortic stenosis (HP:0001682)2.58368656
75Abnormality of the left ventricular outflow tract (HP:0011103)2.58368656
76Vascular calcification (HP:0004934)2.57813121
77EMG: myopathic abnormalities (HP:0003458)2.57445735
78Metabolic acidosis (HP:0001942)2.55985417
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.55353283
80Chest pain (HP:0100749)2.55260941
81Microcytic anemia (HP:0001935)2.54292313
82Delayed CNS myelination (HP:0002188)2.53847365
83Keratoconjunctivitis (HP:0001096)2.48350379
84Abnormality of serum amino acid levels (HP:0003112)2.45025364
85Epistaxis (HP:0000421)2.44441403
86Cholelithiasis (HP:0001081)2.44047254
87Hemiplegia (HP:0002301)2.43928415
88Gout (HP:0001997)2.43502694
89Polycythemia (HP:0001901)2.42974787
90Hepatocellular carcinoma (HP:0001402)2.42038599
91Gingivitis (HP:0000230)2.41417302
92Recurrent skin infections (HP:0001581)2.40819878
93Meningitis (HP:0001287)2.40337927
94Slow saccadic eye movements (HP:0000514)2.40264960
95Autoimmune hemolytic anemia (HP:0001890)2.38591593
96Encephalitis (HP:0002383)2.38588638
97Hypochromic microcytic anemia (HP:0004840)2.36813927
98Hypochromic anemia (HP:0001931)2.36556382
99Cardiovascular calcification (HP:0011915)2.36245920
100Exercise-induced myalgia (HP:0003738)2.33598411
101Bundle branch block (HP:0011710)2.33398668
102Postural instability (HP:0002172)2.32687161
103Systemic lupus erythematosus (HP:0002725)2.32106294
104Frequent falls (HP:0002359)2.31856563
105Sudden death (HP:0001699)2.31790558
106Hemorrhage of the eye (HP:0011885)2.30836836
107Exercise-induced muscle cramps (HP:0003710)2.29924500
108Arterial thrombosis (HP:0004420)2.29654221
109Elevated erythrocyte sedimentation rate (HP:0003565)2.29643990
110Abnormality of nucleobase metabolism (HP:0010932)2.29442965
111Generalized aminoaciduria (HP:0002909)2.28001285
112Type 1 muscle fiber predominance (HP:0003803)2.26804764
113Increased IgE level (HP:0003212)2.24679584
114Ventricular fibrillation (HP:0001663)2.23996441
115Abnormality of binocular vision (HP:0011514)2.22424971
116Diplopia (HP:0000651)2.22424971
117Recurrent cutaneous fungal infections (HP:0011370)2.21623456
118Chronic mucocutaneous candidiasis (HP:0002728)2.21623456
119Pulmonary embolism (HP:0002204)2.21170540
120Pulmonary infiltrates (HP:0002113)2.19303171
121Esophageal varix (HP:0002040)2.18253645
122Abnormality of skeletal muscle fiber size (HP:0012084)2.16947065
123Spastic diplegia (HP:0001264)2.15959596
124Hyperglycemia (HP:0003074)2.15825789
125Acanthocytosis (HP:0001927)2.13212376
126Mediastinal lymphadenopathy (HP:0100721)2.12028640
127Leukocytosis (HP:0001974)2.11774055
128Neurofibrillary tangles (HP:0002185)2.11581318
129Abnormality of T cells (HP:0002843)2.08751965
130Asymmetric septal hypertrophy (HP:0001670)2.07839844
131Increased variability in muscle fiber diameter (HP:0003557)2.07340906
132Vertigo (HP:0002321)2.07244792
133Obstructive lung disease (HP:0006536)2.06232983
134Chronic obstructive pulmonary disease (HP:0006510)2.06232983
135Pancreatitis (HP:0001733)2.04694335
136EMG: neuropathic changes (HP:0003445)2.04203812
137Recurrent viral infections (HP:0004429)2.02808714
138Lethargy (HP:0001254)2.02717279
139Hemoptysis (HP:0002105)2.02332483
140Amyloidosis (HP:0011034)2.00703906
141Inflammation of the large intestine (HP:0002037)2.00391324
142Right ventricular cardiomyopathy (HP:0011663)1.96271776
143Pustule (HP:0200039)1.96094703
144Osteomyelitis (HP:0002754)1.95161622
145Gingival bleeding (HP:0000225)1.94934888
146Urticaria (HP:0001025)1.94895226
147Muscle fiber splitting (HP:0003555)1.94670889
148Centrally nucleated skeletal muscle fibers (HP:0003687)1.93932183
149Abnormality of the fingertips (HP:0001211)1.93294841
150Increased connective tissue (HP:0009025)1.91911840
151Foot dorsiflexor weakness (HP:0009027)1.91543416
152Spontaneous abortion (HP:0005268)1.91300596
153Irritability (HP:0000737)1.91046687
154Rhabdomyolysis (HP:0003201)1.90528873
155Colitis (HP:0002583)1.89299548
156Cellulitis (HP:0100658)1.88803892
157Abnormal platelet volume (HP:0011876)1.88700869
158Abnormality of vitamin metabolism (HP:0100508)1.88214217
159Abnormality of the foot musculature (HP:0001436)1.88002400
160Visual hallucinations (HP:0002367)1.87523170
161Cerebral edema (HP:0002181)1.86941568
162Abnormality of the gallbladder (HP:0005264)1.86039855
163Abnormality of the endocardium (HP:0004306)1.85442088
164Rickets (HP:0002748)1.83818056
165Toxemia of pregnancy (HP:0100603)1.83708791
166Gangrene (HP:0100758)1.83100587
167Back pain (HP:0003418)1.83058201
168Vomiting (HP:0002013)1.82411392
169Eosinophilia (HP:0001880)1.82190509
170Recurrent bronchitis (HP:0002837)1.81649707
171Axonal loss (HP:0003447)1.81511821
172Increased purine levels (HP:0004368)1.79763173
173Hyperuricemia (HP:0002149)1.79763173
174Mitral stenosis (HP:0001718)1.79687448
175Symptomatic seizures (HP:0011145)1.79675420
176Gastrointestinal inflammation (HP:0004386)1.79529608
177Sensorimotor neuropathy (HP:0007141)1.79511286
178Degeneration of the lateral corticospinal tracts (HP:0002314)1.79468266
179Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79468266
180Glomerulonephritis (HP:0000099)1.79451950
181Abnormal enzyme/coenzyme activity (HP:0012379)1.78998737
182Hydroxyprolinuria (HP:0003080)1.78619308
183Abnormality of proline metabolism (HP:0010907)1.78619308
184Abnormality of the calf musculature (HP:0001430)1.78334872
185Difficulty running (HP:0009046)1.77316829
186Late onset (HP:0003584)1.76886798
187Pancreatic islet-cell hyperplasia (HP:0004510)1.76648302
188Abnormality of transition element cation homeostasis (HP:0011030)1.75341480
189Pigmentary retinal degeneration (HP:0001146)1.75157378
190Cerebral hemorrhage (HP:0001342)1.74954506
191Renal cortical cysts (HP:0000803)1.72715688

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.32850919
2RIPK43.45009369
3EPHB13.24188148
4STK393.06842196
5PRPF4B2.75194292
6FGFR22.57565466
7FGFR42.51001947
8SIK12.49171164
9INSRR2.36791849
10BLK2.21255914
11MAP4K12.20960159
12TTN2.11718205
13MET2.03499501
14GRK61.99368588
15TRIB31.96796249
16FRK1.86359499
17RIPK11.82490193
18FES1.80483875
19TAOK31.77181632
20WNK41.76690182
21SGK21.76029418
22PKN21.75628709
23TXK1.71896623
24ERN11.71536625
25CAMK1D1.65917528
26SYK1.63555456
27LATS11.63188872
28MAP3K131.62771317
29ZAP701.60575248
30OBSCN1.55245857
31OXSR11.49369468
32PHKG11.46772789
33PHKG21.46772789
34KSR21.45764375
35PKN11.42093876
36WNK11.41379841
37PTK61.40914224
38IRAK41.40701223
39BTK1.35599896
40PRKAA21.33730240
41FGR1.32755455
42PDK41.30932797
43PDK31.30932797
44BMPR21.28511564
45PINK11.26941937
46PDK21.25861922
47MAP3K11.25267873
48PTK2B1.22609423
49TNK21.22473355
50JAK31.21812519
51MST1R1.19582997
52FLT31.17762151
53TEC1.16215237
54TYK21.15752906
55CAMK1G1.15387390
56PIK3CG1.15149356
57HCK1.14143254
58MAP3K71.13269113
59PIK3CA1.11369861
60TAOK11.10044416
61TGFBR21.09696809
62MARK31.09402315
63JAK11.08866769
64NTRK31.08796682
65ERBB41.06387052
66TRPM71.05858131
67FGFR31.04303292
68GRK51.01566919
69PBK1.00672659
70JAK20.99543008
71GSK3A0.94435283
72PRKD10.91690904
73PRKAA10.90866352
74TIE10.89989180
75MARK20.89473072
76LYN0.87677054
77YES10.86979524
78NEK90.85603832
79PDPK10.84641216
80SGK10.83975500
81SGK4940.83830132
82SGK2230.83830132
83KSR10.82648935
84MAP2K30.82148638
85IRAK10.78873854
86LCK0.78798327
87MAPK150.78200120
88CSK0.77820089
89MAPK110.76472879
90STK380.75209959
91LMTK20.74382218
92PIM10.72999822
93EPHA30.72325812
94MAP3K20.72243126
95NLK0.71733649
96PDK10.71516881
97STK110.69720917
98PAK30.68363829
99ICK0.67667501
100CAMK2G0.66946092
101MAP3K100.66480189
102MST40.65958124
103CDK60.65602071
104PRKCQ0.64187284
105CAMK40.62327747
106RAF10.62270336
107DAPK20.61209655
108SGK30.60955098
109UHMK10.59900465
110MAPK120.59845076
111NTRK20.59739379
112MAP2K40.59354563
113NEK60.59099935
114CAMKK10.58328973
115PRKCH0.57898605
116DYRK1B0.57744278
117STK30.57694384
118RET0.57324634
119MAP3K60.56953225
120CDC42BPA0.56285183
121IRAK20.55949031
122CAMKK20.55659236
123STK100.55448769
124MAP3K140.54994831
125MAP2K20.53362019
126PDGFRA0.52501346
127FYN0.52417815
128MAP3K50.52309756
129CSF1R0.52198432
130MAP3K30.52132351
131CAMK2D0.52031503
132BMX0.51927920
133ACVR1B0.51837230
134HIPK20.51777539
135ITK0.50713507
136STK40.49298857
137IKBKE0.48636330
138PDGFRB0.48613724
139PRKACG0.48370034
140MAP3K110.48015689
141DYRK1A0.47954140
142TBK10.47587297
143CSNK1A1L0.47210197
144MAPKAPK50.47169706
145DMPK0.46583225
146MTOR0.43747468
147LRRK20.43650102
148MYLK0.43242033
149PTK20.42853294
150CSNK1G10.42778243
151IRAK30.39270566
152MAPK70.39213691
153GRK10.38355712
154AKT30.37907311

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.18022513
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.50777622
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86246430
4Fatty acid degradation_Homo sapiens_hsa000712.77607139
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73977557
6Arginine biosynthesis_Homo sapiens_hsa002202.69294468
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66027117
8Propanoate metabolism_Homo sapiens_hsa006402.62597841
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.54113001
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38651759
11Tryptophan metabolism_Homo sapiens_hsa003802.37564712
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21889271
13Fatty acid metabolism_Homo sapiens_hsa012122.20646381
14Butanoate metabolism_Homo sapiens_hsa006502.18116911
15Complement and coagulation cascades_Homo sapiens_hsa046102.15244232
16PPAR signaling pathway_Homo sapiens_hsa033202.02134962
17Peroxisome_Homo sapiens_hsa041461.99458765
18B cell receptor signaling pathway_Homo sapiens_hsa046621.96997602
19Osteoclast differentiation_Homo sapiens_hsa043801.95205285
20Fatty acid elongation_Homo sapiens_hsa000621.94435266
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85281454
22Histidine metabolism_Homo sapiens_hsa003401.77822378
23Sulfur metabolism_Homo sapiens_hsa009201.77800058
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77728144
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77529725
26Leishmaniasis_Homo sapiens_hsa051401.73364088
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70551574
28T cell receptor signaling pathway_Homo sapiens_hsa046601.69074601
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68832581
30beta-Alanine metabolism_Homo sapiens_hsa004101.65379157
31Caffeine metabolism_Homo sapiens_hsa002321.65181231
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61182410
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58938776
34Chemical carcinogenesis_Homo sapiens_hsa052041.58769633
35Pyruvate metabolism_Homo sapiens_hsa006201.50212910
36Non-small cell lung cancer_Homo sapiens_hsa052231.46922931
37Steroid biosynthesis_Homo sapiens_hsa001001.46197985
38Long-term potentiation_Homo sapiens_hsa047201.46112949
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45204770
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43637301
41Staphylococcus aureus infection_Homo sapiens_hsa051501.43255912
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.43176718
43ABC transporters_Homo sapiens_hsa020101.43150031
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41459620
45Bile secretion_Homo sapiens_hsa049761.39572136
46Platelet activation_Homo sapiens_hsa046111.37974059
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37755191
48Malaria_Homo sapiens_hsa051441.36433610
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32970046
50Retinol metabolism_Homo sapiens_hsa008301.32751852
51Chemokine signaling pathway_Homo sapiens_hsa040621.32738799
52Selenocompound metabolism_Homo sapiens_hsa004501.31228441
53Tuberculosis_Homo sapiens_hsa051521.30395651
54Starch and sucrose metabolism_Homo sapiens_hsa005001.25593332
55Carbon metabolism_Homo sapiens_hsa012001.23331634
56Tyrosine metabolism_Homo sapiens_hsa003501.19104254
57Acute myeloid leukemia_Homo sapiens_hsa052211.18582059
58Fat digestion and absorption_Homo sapiens_hsa049751.18566007
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18069439
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.17419918
61Phenylalanine metabolism_Homo sapiens_hsa003601.17323898
62Fatty acid biosynthesis_Homo sapiens_hsa000611.16967389
63Primary immunodeficiency_Homo sapiens_hsa053401.16244161
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.16162583
65Hematopoietic cell lineage_Homo sapiens_hsa046401.15107667
66Measles_Homo sapiens_hsa051621.11660816
67VEGF signaling pathway_Homo sapiens_hsa043701.10443923
68Graft-versus-host disease_Homo sapiens_hsa053321.10113511
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09359736
70NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09168827
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07987488
72Renal cell carcinoma_Homo sapiens_hsa052111.06604676
73Renin secretion_Homo sapiens_hsa049241.05104992
74FoxO signaling pathway_Homo sapiens_hsa040681.04777460
75GnRH signaling pathway_Homo sapiens_hsa049121.02839902
76Circadian rhythm_Homo sapiens_hsa047101.02288308
77Folate biosynthesis_Homo sapiens_hsa007901.02096260
78Drug metabolism - other enzymes_Homo sapiens_hsa009831.01857725
79Biosynthesis of amino acids_Homo sapiens_hsa012301.01792631
80Prolactin signaling pathway_Homo sapiens_hsa049171.01457285
81Lysine degradation_Homo sapiens_hsa003101.01352863
82Neurotrophin signaling pathway_Homo sapiens_hsa047221.00226979
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.99857896
84Arginine and proline metabolism_Homo sapiens_hsa003300.99758170
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99297910
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99282779
87Allograft rejection_Homo sapiens_hsa053300.98206913
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.98027072
89Autoimmune thyroid disease_Homo sapiens_hsa053200.97963194
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97890724
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96182382
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.95765158
93Toxoplasmosis_Homo sapiens_hsa051450.95743495
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95542933
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95200889
96Pancreatic cancer_Homo sapiens_hsa052120.94561627
97Vitamin B6 metabolism_Homo sapiens_hsa007500.93248794
98Endometrial cancer_Homo sapiens_hsa052130.91548343
99Choline metabolism in cancer_Homo sapiens_hsa052310.90397205
100Glioma_Homo sapiens_hsa052140.89683479
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.89234617
102Oxytocin signaling pathway_Homo sapiens_hsa049210.87820357
103Glycerolipid metabolism_Homo sapiens_hsa005610.87713350
104TNF signaling pathway_Homo sapiens_hsa046680.87169045
105Gastric acid secretion_Homo sapiens_hsa049710.86421351
106Chronic myeloid leukemia_Homo sapiens_hsa052200.84997229
107mTOR signaling pathway_Homo sapiens_hsa041500.84475353
108Influenza A_Homo sapiens_hsa051640.82300684
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80995070
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.78164428
111Long-term depression_Homo sapiens_hsa047300.78070964
112Circadian entrainment_Homo sapiens_hsa047130.77498488
113African trypanosomiasis_Homo sapiens_hsa051430.77301733
114Estrogen signaling pathway_Homo sapiens_hsa049150.76901593
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75739831
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75648751
117Vitamin digestion and absorption_Homo sapiens_hsa049770.74700146
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74099847
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73771351
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73236416
121Viral myocarditis_Homo sapiens_hsa054160.72761865
122Pancreatic secretion_Homo sapiens_hsa049720.71978819
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70590201
124Cholinergic synapse_Homo sapiens_hsa047250.70222244
125Amphetamine addiction_Homo sapiens_hsa050310.69510512
126Hepatitis B_Homo sapiens_hsa051610.69065049
127Type I diabetes mellitus_Homo sapiens_hsa049400.69056702
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.68867832
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.67623785
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67552841
131ErbB signaling pathway_Homo sapiens_hsa040120.67417282
132* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66516915
133cAMP signaling pathway_Homo sapiens_hsa040240.64011251
134Morphine addiction_Homo sapiens_hsa050320.63873004
135MAPK signaling pathway_Homo sapiens_hsa040100.63255425
136Salivary secretion_Homo sapiens_hsa049700.63237932
137Insulin resistance_Homo sapiens_hsa049310.61764523
138Calcium signaling pathway_Homo sapiens_hsa040200.61675055
139Legionellosis_Homo sapiens_hsa051340.59518702
140Glutathione metabolism_Homo sapiens_hsa004800.57375512
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57373370
142Insulin secretion_Homo sapiens_hsa049110.57150132
143Regulation of autophagy_Homo sapiens_hsa041400.55099659
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54045550
145Linoleic acid metabolism_Homo sapiens_hsa005910.45956197
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.40625149
147Sulfur relay system_Homo sapiens_hsa041220.39310250
148Pentose phosphate pathway_Homo sapiens_hsa000300.39064070
149AMPK signaling pathway_Homo sapiens_hsa041520.37731197
150Metabolic pathways_Homo sapiens_hsa011000.36142666
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32587888
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.31474388
153Prion diseases_Homo sapiens_hsa050200.25324557
154Glucagon signaling pathway_Homo sapiens_hsa049220.24439709
155Ether lipid metabolism_Homo sapiens_hsa005650.23607544
156Fructose and mannose metabolism_Homo sapiens_hsa000510.22500646
157Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15382382
158Lysosome_Homo sapiens_hsa041420.08763085
159Insulin signaling pathway_Homo sapiens_hsa049100.08040484
160Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07771740
161One carbon pool by folate_Homo sapiens_hsa006700.05099794
162Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.05063960
163Ovarian steroidogenesis_Homo sapiens_hsa049130.04611337
164Amoebiasis_Homo sapiens_hsa051460.04387603
165Galactose metabolism_Homo sapiens_hsa000520.04326076
166Mineral absorption_Homo sapiens_hsa049780.02909127
167Protein digestion and absorption_Homo sapiens_hsa049740.02806984
168Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.02150407
169Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00654374
170Dilated cardiomyopathy_Homo sapiens_hsa054140.00534470
171Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0527781
172Hepatitis C_Homo sapiens_hsa05160-0.0494866
173Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0253519
174Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0247930
175Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0186813
176ECM-receptor interaction_Homo sapiens_hsa04512-0.0182003
177Type II diabetes mellitus_Homo sapiens_hsa04930-0.0125750
178Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0116903

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