KAT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.56026605
2N-acetylneuraminate metabolic process (GO:0006054)4.54861174
3amino sugar catabolic process (GO:0046348)4.35030974
4negative regulation of erythrocyte differentiation (GO:0045647)4.32619342
5regulation of centriole replication (GO:0046599)4.21130303
6peptidyl-arginine omega-N-methylation (GO:0035247)4.20045873
7protoporphyrinogen IX biosynthetic process (GO:0006782)4.19685713
8cellular extravasation (GO:0045123)4.12601375
9spliceosomal tri-snRNP complex assembly (GO:0000244)3.94578828
10response to peptidoglycan (GO:0032494)3.91518953
11nucleosome disassembly (GO:0006337)3.90471110
12protein-DNA complex disassembly (GO:0032986)3.90471110
13positive regulation of histone deacetylation (GO:0031065)3.80829424
14peptidyl-arginine N-methylation (GO:0035246)3.72112889
15peptidyl-arginine methylation (GO:0018216)3.72112889
16regulation of translational termination (GO:0006449)3.69055187
17positive regulation of gamma-delta T cell activation (GO:0046645)3.66362508
18protoporphyrinogen IX metabolic process (GO:0046501)3.64107008
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62131529
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.62131529
21modulation by symbiont of host immune response (GO:0052553)3.62131529
22positive regulation by symbiont of host defense response (GO:0052509)3.62131529
23modulation by symbiont of host defense response (GO:0052031)3.62131529
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62131529
25positive regulation of chemokine biosynthetic process (GO:0045080)3.55227391
26pre-miRNA processing (GO:0031054)3.54273263
27histone arginine methylation (GO:0034969)3.54141700
28DNA unwinding involved in DNA replication (GO:0006268)3.51505969
29regulation of chromatin binding (GO:0035561)3.48976585
30negative regulation of microtubule polymerization (GO:0031115)3.47590142
31peptidyl-lysine dimethylation (GO:0018027)3.47209101
32histone H2A acetylation (GO:0043968)3.47133491
33regulation of chemokine biosynthetic process (GO:0045073)3.46343289
34COPI coating of Golgi vesicle (GO:0048205)3.43117244
35Golgi transport vesicle coating (GO:0048200)3.43117244
36NIK/NF-kappaB signaling (GO:0038061)3.43023795
37positive regulation of protein deacetylation (GO:0090312)3.41993808
38positive regulation of synapse maturation (GO:0090129)3.41461956
39modulation by virus of host process (GO:0019054)3.41089422
40regulation of NFAT protein import into nucleus (GO:0051532)3.37883603
41modulation by symbiont of host cellular process (GO:0044068)3.36634531
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.36001181
43negative regulation of organelle assembly (GO:1902116)3.33909640
44synaptic vesicle maturation (GO:0016188)3.33853068
45sodium ion export (GO:0071436)3.33733915
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30018803
47translesion synthesis (GO:0019985)3.29758588
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.28976597
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28450012
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14133185
51negative regulation of cell killing (GO:0031342)3.12395534
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12395534
53regulation of translational fidelity (GO:0006450)3.09684202
54antigen processing and presentation of endogenous antigen (GO:0019883)3.08670378
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08482847
56GMP metabolic process (GO:0046037)3.08313349
57macrophage activation involved in immune response (GO:0002281)3.02892004
58germinal center formation (GO:0002467)3.01376387
59response to muramyl dipeptide (GO:0032495)2.99687707
60microglial cell activation (GO:0001774)2.96597800
61RNA localization (GO:0006403)2.96280657
62dosage compensation (GO:0007549)2.92849450
63locomotory exploration behavior (GO:0035641)2.92468910
64purine deoxyribonucleotide catabolic process (GO:0009155)2.89577951
65mannose metabolic process (GO:0006013)2.89168902
66regulation of RNA export from nucleus (GO:0046831)2.89166689
673-UTR-mediated mRNA stabilization (GO:0070935)2.88387023
68antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87199574
69pyrimidine nucleoside salvage (GO:0043097)2.86525698
70pyrimidine-containing compound salvage (GO:0008655)2.86525698
71leukocyte aggregation (GO:0070486)2.85481383
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.84704316
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83863955
74response to host immune response (GO:0052572)2.83863955
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82215538
76regulation of DNA damage checkpoint (GO:2000001)2.77509488
77macrophage activation (GO:0042116)2.77404516
78chaperone mediated protein folding requiring cofactor (GO:0051085)2.77215011
79DNA replication-dependent nucleosome assembly (GO:0006335)2.76236072
80DNA replication-dependent nucleosome organization (GO:0034723)2.76236072
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76067183
82mitotic nuclear envelope disassembly (GO:0007077)2.74191964
83protein localization to chromosome, centromeric region (GO:0071459)2.73975342
84nuclear envelope disassembly (GO:0051081)2.73510387
85membrane disassembly (GO:0030397)2.73510387
86regulation of T-helper 2 cell differentiation (GO:0045628)2.72849741
87negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72801957
88gene silencing by RNA (GO:0031047)2.72598087
89protein insertion into membrane (GO:0051205)2.72590006
90UV protection (GO:0009650)2.71954525
91negative regulation of cell size (GO:0045792)2.71513834
92protein localization to kinetochore (GO:0034501)2.69411614
93regulation of synapse structural plasticity (GO:0051823)2.69012344
94negative regulation of interleukin-12 production (GO:0032695)2.68978604
95activation of MAPKKK activity (GO:0000185)2.68444005
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67596094
97response to host (GO:0075136)2.67596094
98response to host defenses (GO:0052200)2.67596094
99detection of other organism (GO:0098543)2.67104050
100postreplication repair (GO:0006301)2.66425378
101neutrophil mediated immunity (GO:0002446)2.66148988
102alternative mRNA splicing, via spliceosome (GO:0000380)2.65939590
103negative regulation of histone methylation (GO:0031061)2.65634681
104regulation of ARF protein signal transduction (GO:0032012)2.64962834
105glycosphingolipid catabolic process (GO:0046479)2.64206722
106gene silencing (GO:0016458)2.63741807
107regulation of gamma-delta T cell activation (GO:0046643)2.63595263
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.62581744
109NLS-bearing protein import into nucleus (GO:0006607)2.62105627
110detection of bacterium (GO:0016045)2.62030294
111negative regulation of gene expression, epigenetic (GO:0045814)2.61529745
112immunoglobulin mediated immune response (GO:0016064)2.60710334
113regulation of interferon-beta biosynthetic process (GO:0045357)2.60003059
114binding of sperm to zona pellucida (GO:0007339)2.59632411
115cellular response to type I interferon (GO:0071357)2.59487749
116type I interferon signaling pathway (GO:0060337)2.59487749
117cilium or flagellum-dependent cell motility (GO:0001539)2.58262267
118barbed-end actin filament capping (GO:0051016)2.58119212
119positive regulation of B cell differentiation (GO:0045579)2.57943497
120protein targeting to plasma membrane (GO:0072661)2.57893470
121response to protozoan (GO:0001562)2.57763144
122regulation of defense response to virus by virus (GO:0050690)2.56924117
123regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56841177
124regulation of T-helper 1 cell differentiation (GO:0045625)2.56538425
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56386865
126response to type I interferon (GO:0034340)2.56352731
127negative regulation of RNA splicing (GO:0033119)2.55052567
128regulation of leukocyte degranulation (GO:0043300)2.54958634
129regulation of mast cell degranulation (GO:0043304)2.53912518
130regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53898045
131regulation of vitamin D biosynthetic process (GO:0060556)2.53615800
132pentose-phosphate shunt (GO:0006098)2.53270007
133regulation of centrosome cycle (GO:0046605)2.53187423
134neutrophil activation involved in immune response (GO:0002283)2.52547603
135protein localization to chromosome (GO:0034502)2.52405072
136chromatin silencing (GO:0006342)2.51621683
137cytoskeletal anchoring at plasma membrane (GO:0007016)2.51279815
138positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.50084575
139respiratory burst (GO:0045730)2.49962660
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.49462277
141myeloid dendritic cell differentiation (GO:0043011)2.49256630
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.49230194
143synaptonemal complex assembly (GO:0007130)2.48451738
144reactive oxygen species biosynthetic process (GO:1903409)2.47773995
145nucleotide salvage (GO:0043173)2.47598440
146negative regulation of innate immune response (GO:0045824)2.47440989
147regulation of nucleobase-containing compound transport (GO:0032239)2.47420827
148sperm-egg recognition (GO:0035036)2.47330057
149heme biosynthetic process (GO:0006783)2.46448070
150layer formation in cerebral cortex (GO:0021819)2.46240348
151amyloid precursor protein catabolic process (GO:0042987)2.46230767
152* negative regulation of interleukin-2 production (GO:0032703)2.45921495
153positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.45837256
154phagosome maturation (GO:0090382)2.45287560
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45175491
156negative regulation of type 2 immune response (GO:0002829)2.44889911
157antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.44286807
158synaptic vesicle exocytosis (GO:0016079)2.43249099
159peptidyl-arginine modification (GO:0018195)2.42669713
160positive regulation of gene expression, epigenetic (GO:0045815)2.42616247
161regulation of monocyte differentiation (GO:0045655)2.42214026
162regulation of inclusion body assembly (GO:0090083)2.41572936
163regulation of MHC class II biosynthetic process (GO:0045346)2.41185168
164glycolipid catabolic process (GO:0019377)2.40468526
165regulation of spindle organization (GO:0090224)2.40122845
166retinal cone cell development (GO:0046549)2.39824355
167mitotic sister chromatid segregation (GO:0000070)2.39495153
168phosphatidylglycerol biosynthetic process (GO:0006655)2.38490878
169regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38452581
170antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.37753115
171antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.37753115
172regulation of clathrin-mediated endocytosis (GO:2000369)2.37554987
173cell-cell recognition (GO:0009988)2.37433171
174regulation of histone H3-K9 methylation (GO:0051570)2.37093145
175regulation of gamma-delta T cell differentiation (GO:0045586)2.36921923
176regulation of superoxide anion generation (GO:0032928)2.36880198
177mature B cell differentiation involved in immune response (GO:0002313)2.36867951
178galactose catabolic process (GO:0019388)2.36236399
179regulation of dendritic cell antigen processing and presentation (GO:0002604)2.35757025
180ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.35241575
181sister chromatid segregation (GO:0000819)2.35177308
182regulation of mitotic spindle organization (GO:0060236)2.34067615
183microtubule severing (GO:0051013)2.33973395
184regulation of translational elongation (GO:0006448)2.33136665
185positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32779026
186regulation of histone deacetylation (GO:0031063)2.31949520
187defense response to protozoan (GO:0042832)2.31838439
188stress granule assembly (GO:0034063)2.31338254
189cellular response to thyroid hormone stimulus (GO:0097067)2.30768350
190histone H4-K8 acetylation (GO:0043982)2.30240447
191histone H4-K5 acetylation (GO:0043981)2.30240447
192negative regulation of microtubule polymerization or depolymerization (GO:0031111)2.30186317
193histone H4 acetylation (GO:0043967)2.29340377
194cellular potassium ion homeostasis (GO:0030007)2.27543220
195regulation of synaptic vesicle exocytosis (GO:2000300)2.27520988
196positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.27244133
197sexual reproduction (GO:0019953)2.26185858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.47923725
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.45653067
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.43823416
4MYC_22102868_ChIP-Seq_BL_Human3.35092602
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77105906
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.60826627
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.52935526
8CIITA_25753668_ChIP-Seq_RAJI_Human2.30004905
9VDR_21846776_ChIP-Seq_THP-1_Human2.26828013
10* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.14674452
11* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10822110
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09303426
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.07044947
14CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.06130595
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04198302
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03390496
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02434883
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01252413
19ZFP281_18757296_ChIP-ChIP_E14_Mouse1.98935717
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98611410
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98363950
22CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.97263482
23VDR_24763502_ChIP-Seq_THP-1_Human1.89556929
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87343184
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85383751
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84541039
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.84274508
28SCL_19346495_ChIP-Seq_HPC-7_Human1.82079160
29KDM2B_26808549_Chip-Seq_DND41_Human1.81807048
30RACK7_27058665_Chip-Seq_MCF-7_Human1.78808274
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.76534199
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76159031
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73477126
34TCF7_22412390_ChIP-Seq_EML_Mouse1.71555496
35* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70213468
36XRN2_22483619_ChIP-Seq_HELA_Human1.68506891
37* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.66544502
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66093039
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65007485
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63630504
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.63572941
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61891172
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59759991
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58400753
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57063732
46* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.55372649
47* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55181978
48P68_20966046_ChIP-Seq_HELA_Human1.55150900
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.53599590
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50563333
51LXR_22292898_ChIP-Seq_THP-1_Human1.50224234
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49515089
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47378335
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46980886
55GATA1_19941827_ChIP-Seq_MEL_Mouse1.46317454
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46069597
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44984959
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44774111
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44233906
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41536658
61* SPI1_23547873_ChIP-Seq_NB4_Human1.40944253
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.40592401
63* SA1_27219007_Chip-Seq_ERYTHROID_Human1.40156167
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.39136437
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38753123
66UTX_26944678_Chip-Seq_JUKART_Human1.38308384
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37517684
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.36953849
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36083147
70PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35206493
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34133294
72SPI1_23127762_ChIP-Seq_K562_Human1.32590513
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32387422
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31344113
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31133868
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31059106
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30742818
78BCL6_27268052_Chip-Seq_Bcells_Human1.30008409
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28321182
80MAF_26560356_Chip-Seq_TH1_Human1.28178470
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27455226
82PHF8_20622854_ChIP-Seq_HELA_Human1.27383712
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26603328
84GATA1_19941826_ChIP-Seq_K562_Human1.26580536
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26324567
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25407872
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.25245712
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24946110
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24529744
90* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23259129
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21875230
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21868926
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21311290
94TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20923433
95* TFEB_21752829_ChIP-Seq_HELA_Human1.20638411
96KDM2B_26808549_Chip-Seq_K562_Human1.20636904
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20538162
98ZNF263_19887448_ChIP-Seq_K562_Human1.20513817
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19999231
100BCOR_27268052_Chip-Seq_Bcells_Human1.19521158
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19483553
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.19236829
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18802215
104* GABP_19822575_ChIP-Seq_HepG2_Human1.18438455
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18364690
106FOXP1_21924763_ChIP-Seq_HESCs_Human1.18018919
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17310120
108AR_21909140_ChIP-Seq_LNCAP_Human1.14671852
109ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14391398
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13999336
111* SMC4_20622854_ChIP-Seq_HELA_Human1.13920196
112MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13862288
113* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13119357
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11168638
115NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10988399
116CTCF_26484167_Chip-Seq_Bcells_Mouse1.10730453
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10257376
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10130283
119IRF8_27001747_Chip-Seq_BMDM_Mouse1.09429001
120KDM2B_26808549_Chip-Seq_JURKAT_Human1.08958320
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08322430
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08185638
123CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07848765
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07707311
125MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07339074
126* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06530644
127* RARB_24833708_ChIP-Seq_LIVER_Mouse1.05309897
128CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05142690
129* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04445349
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.04411080
131TET1_21451524_ChIP-Seq_MESCs_Mouse1.03821538
132PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03460950
133* MAF_26560356_Chip-Seq_TH2_Human1.03176811
134* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02838745
135YY1_22570637_ChIP-Seq_MALME-3M_Human1.02769608
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02360202
137ATF3_27146783_Chip-Seq_COLON_Human1.02033373
138NCOR1_26117541_ChIP-Seq_K562_Human1.01308230
139* CREB1_26743006_Chip-Seq_LNCaP_Human1.01252695
140E2F1_20622854_ChIP-Seq_HELA_Human1.00575220
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00319998
142NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00204278
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00000924
144* ETS1_20019798_ChIP-Seq_JURKAT_Human0.97253262
145E2F1_21310950_ChIP-Seq_MCF-7_Human0.96760762
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.96304587
147HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96052478
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95598511
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94936671
150* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94105033
151SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92173217
152TTF2_22483619_ChIP-Seq_HELA_Human0.91476642
153* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91308689
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91202754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.35200893
2MP0005451_abnormal_body_composition4.06820706
3MP0004859_abnormal_synaptic_plasticity3.77881184
4MP0003436_decreased_susceptibility_to3.43571889
5MP0005083_abnormal_biliary_tract3.32392921
6MP0005058_abnormal_lysosome_morphology3.02955594
7MP0001986_abnormal_taste_sensitivity2.88935049
8MP0005076_abnormal_cell_differentiation2.79143011
9MP0005410_abnormal_fertilization2.54526527
10MP0003693_abnormal_embryo_hatching2.51523279
11MP0005423_abnormal_somatic_nervous2.45437759
12MP0003183_abnormal_peptide_metabolism2.44217914
13MP0009840_abnormal_foam_cell2.41072999
14MP0008961_abnormal_basal_metabolism2.39071141
15MP0006082_CNS_inflammation2.38814986
16MP0008260_abnormal_autophagy2.37793112
17MP0003191_abnormal_cellular_cholesterol2.31162083
18MP0002419_abnormal_innate_immunity2.20209667
19MP0010352_gastrointestinal_tract_polyps2.17548761
20MP0005000_abnormal_immune_tolerance2.13832914
21MP0005025_abnormal_response_to2.12604383
22MP0003111_abnormal_nucleus_morphology2.11177938
23MP0002148_abnormal_hypersensitivity_rea2.09916394
24MP0003724_increased_susceptibility_to2.03182007
25MP0001730_embryonic_growth_arrest2.00226776
26MP0001835_abnormal_antigen_presentation2.00186557
27MP0005387_immune_system_phenotype1.95021674
28MP0001790_abnormal_immune_system1.95021674
29MP0005167_abnormal_blood-brain_barrier1.90549467
30MP0001348_abnormal_lacrimal_gland1.89491451
31MP0010307_abnormal_tumor_latency1.88092716
32MP0002909_abnormal_adrenal_gland1.87278627
33MP0003123_paternal_imprinting1.85209624
34MP0004947_skin_inflammation1.85185753
35MP0004957_abnormal_blastocyst_morpholog1.80186918
36MP0003763_abnormal_thymus_physiology1.77017930
37MP0008877_abnormal_DNA_methylation1.76723549
38MP0010094_abnormal_chromosome_stability1.75712981
39MP0002723_abnormal_immune_serum1.75474949
40* MP0002452_abnormal_antigen_presenting1.75378160
41MP0000685_abnormal_immune_system1.71719001
42* MP0002420_abnormal_adaptive_immunity1.70634560
43* MP0001819_abnormal_immune_cell1.69670282
44MP0001800_abnormal_humoral_immune1.68713353
45MP0004858_abnormal_nervous_system1.67762829
46MP0003075_altered_response_to1.67026235
47MP0003635_abnormal_synaptic_transmissio1.64736975
48MP0000465_gastrointestinal_hemorrhage1.64369605
49MP0003656_abnormal_erythrocyte_physiolo1.63934980
50MP0004811_abnormal_neuron_physiology1.60566640
51MP0001849_ear_inflammation1.60400921
52MP0003011_delayed_dark_adaptation1.59888572
53MP0001533_abnormal_skeleton_physiology1.59730963
54MP0009785_altered_susceptibility_to1.57634471
55MP0004510_myositis1.56285748
56MP0003077_abnormal_cell_cycle1.51964927
57MP0002405_respiratory_system_inflammati1.51170117
58MP0003303_peritoneal_inflammation1.51050664
59MP0001873_stomach_inflammation1.50883244
60MP0003806_abnormal_nucleotide_metabolis1.43223920
61MP0005671_abnormal_response_to1.41818564
62MP0004233_abnormal_muscle_weight1.41487017
63MP0005464_abnormal_platelet_physiology1.40015715
64MP0003698_abnormal_male_reproductive1.39890711
65MP0001929_abnormal_gametogenesis1.39501066
66MP0000751_myopathy1.39436097
67MP0009278_abnormal_bone_marrow1.39209555
68MP0005253_abnormal_eye_physiology1.38627402
69MP0005551_abnormal_eye_electrophysiolog1.37551268
70MP0001845_abnormal_inflammatory_respons1.37550554
71MP0001697_abnormal_embryo_size1.37208579
72MP0000716_abnormal_immune_system1.36857825
73MP0003329_amyloid_beta_deposits1.35424946
74MP0004270_analgesia1.34470489
75MP0003045_fibrosis1.34115092
76MP0003122_maternal_imprinting1.32264243
77MP0009333_abnormal_splenocyte_physiolog1.30997421
78MP0000350_abnormal_cell_proliferation1.28480883
79MP0003453_abnormal_keratinocyte_physiol1.27681175
80MP0009780_abnormal_chondrocyte_physiolo1.27454427
81MP0003283_abnormal_digestive_organ1.27233455
82MP0001853_heart_inflammation1.25718511
83MP0005375_adipose_tissue_phenotype1.24706174
84MP0003705_abnormal_hypodermis_morpholog1.24560238
85MP0002429_abnormal_blood_cell1.24523426
86MP0005499_abnormal_olfactory_system1.22911608
87MP0005394_taste/olfaction_phenotype1.22911608
88MP0002722_abnormal_immune_system1.21634412
89MP0009764_decreased_sensitivity_to1.21276749
90MP0000858_altered_metastatic_potential1.21192168
91MP0002063_abnormal_learning/memory/cond1.20937550
92MP0005310_abnormal_salivary_gland1.19975578
93MP0000343_altered_response_to1.19934970
94MP0010155_abnormal_intestine_physiology1.19702204
95MP0002084_abnormal_developmental_patter1.19342114
96MP0004043_abnormal_pH_regulation1.17396136
97* MP0002080_prenatal_lethality1.17357865
98MP0003121_genomic_imprinting1.16350033
99MP0000689_abnormal_spleen_morphology1.15475955
100MP0008469_abnormal_protein_level1.14158866
101MP0003646_muscle_fatigue1.13755160
102MP0006072_abnormal_retinal_apoptosis1.13421082
103MP0002085_abnormal_embryonic_tissue1.13042333
104MP0000604_amyloidosis1.12831119
105MP0004808_abnormal_hematopoietic_stem1.10613262
106MP0002234_abnormal_pharynx_morphology1.09527252
107MP0003221_abnormal_cardiomyocyte_apopto1.06223085
108MP0005670_abnormal_white_adipose1.04206770
109MP0008874_decreased_physiological_sensi1.04144664
110MP0005365_abnormal_bile_salt1.02484021
111MP0005666_abnormal_adipose_tissue1.02463586
112MP0003300_gastrointestinal_ulcer1.01462756
113MP0001529_abnormal_vocalization1.00830526
114MP0001672_abnormal_embryogenesis/_devel0.99634531
115MP0005380_embryogenesis_phenotype0.99634531
116MP0002132_abnormal_respiratory_system0.99449122
117MP0003828_pulmonary_edema0.98707632
118MP0002161_abnormal_fertility/fecundity0.97700730
119MP0001968_abnormal_touch/_nociception0.97460507
120MP0002184_abnormal_innervation0.96683896
121MP0002210_abnormal_sex_determination0.95491784
122MP0001145_abnormal_male_reproductive0.95175280
123MP0010234_abnormal_vibrissa_follicle0.95166801
124MP0000490_abnormal_crypts_of0.94291654
125MP0009046_muscle_twitch0.94181670
126MP0003172_abnormal_lysosome_physiology0.94161537
127MP0003566_abnormal_cell_adhesion0.93840289
128MP0008569_lethality_at_weaning0.93729229
129MP0002254_reproductive_system_inflammat0.93183646
130MP0003861_abnormal_nervous_system0.92791867
131MP0000703_abnormal_thymus_morphology0.92431883
132MP0002396_abnormal_hematopoietic_system0.91976364
133MP0002877_abnormal_melanocyte_morpholog0.91739315
134MP0000733_abnormal_muscle_development0.90575112
135MP0000013_abnormal_adipose_tissue0.89027944
136MP0002064_seizures0.88595633
137MP0000537_abnormal_urethra_morphology0.88442735
138MP0002882_abnormal_neuron_morphology0.87885054
139MP0002152_abnormal_brain_morphology0.87875109
140MP0003984_embryonic_growth_retardation0.87720020
141MP0002088_abnormal_embryonic_growth/wei0.87432620
142MP0002269_muscular_atrophy0.87084890
143MP0000955_abnormal_spinal_cord0.86722618
144MP0001984_abnormal_olfaction0.86069854
145MP0003866_abnormal_defecation0.85646848
146MP0005166_decreased_susceptibility_to0.85335126
147MP0004197_abnormal_fetal_growth/weight/0.85250334
148MP0000358_abnormal_cell_content/0.85204877
149MP0002398_abnormal_bone_marrow0.84474097
150MP0002086_abnormal_extraembryonic_tissu0.83195800
151MP0000313_abnormal_cell_death0.83115940
152MP0008789_abnormal_olfactory_epithelium0.80219889
153MP0000569_abnormal_digit_pigmentation0.79751543
154MP0003119_abnormal_digestive_system0.79332408
155MP0005621_abnormal_cell_physiology0.78772374
156MP0004185_abnormal_adipocyte_glucose0.78491785
157MP0008932_abnormal_embryonic_tissue0.78026207
158MP0005584_abnormal_enzyme/coenzyme_acti0.78019174
159MP0000534_abnormal_ureter_morphology0.77231716
160* MP0002019_abnormal_tumor_incidence0.76357030
161MP0005397_hematopoietic_system_phenotyp0.76232178
162MP0001545_abnormal_hematopoietic_system0.76232178
163MP0005384_cellular_phenotype0.75800663
164MP0002229_neurodegeneration0.75753272
165MP0002272_abnormal_nervous_system0.75417474
166MP0002998_abnormal_bone_remodeling0.75399512
167MP0000003_abnormal_adipose_tissue0.74781441
168MP0000609_abnormal_liver_physiology0.73555685
169MP0009115_abnormal_fat_cell0.73195914
170MP0000653_abnormal_sex_gland0.73031149
171MP0009931_abnormal_skin_appearance0.72889630
172MP0003091_abnormal_cell_migration0.71796856
173MP0009763_increased_sensitivity_to0.71790987
174MP0005623_abnormal_meninges_morphology0.71682902
175MP0002734_abnormal_mechanical_nocicepti0.70763825
176MP0000747_muscle_weakness0.70697934
177MP0000750_abnormal_muscle_regeneration0.65574402
178MP0004381_abnormal_hair_follicle0.63293926
179MP0009765_abnormal_xenobiotic_induced0.61933303

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.11614437
2Abnormality of glycolipid metabolism (HP:0010969)4.27725787
3Abnormality of liposaccharide metabolism (HP:0010968)4.27725787
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.27725787
5Abnormality of the lower motor neuron (HP:0002366)4.25320031
6Eczematoid dermatitis (HP:0000976)4.22547827
7Recurrent abscess formation (HP:0002722)3.63732533
8Recurrent bacterial skin infections (HP:0005406)3.55742272
9Dysostosis multiplex (HP:0000943)3.53754184
10Abnormality of polysaccharide metabolism (HP:0011012)3.40914265
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.40914265
12Abnormality of mucopolysaccharide metabolism (HP:0011020)3.40914265
13Loss of speech (HP:0002371)3.30199831
14Abnormal gallbladder physiology (HP:0012438)3.29932304
15Cholecystitis (HP:0001082)3.29932304
16Increased cerebral lipofuscin (HP:0011813)3.26854786
17Myositis (HP:0100614)3.25095861
18Hyperacusis (HP:0010780)3.21592745
19Mucopolysacchariduria (HP:0008155)3.20692026
20Urinary glycosaminoglycan excretion (HP:0003541)3.20692026
21Abnormality of macrophages (HP:0004311)3.15806546
22Fatigue (HP:0012378)3.10606648
23Bony spicule pigmentary retinopathy (HP:0007737)3.05558681
24Amyotrophic lateral sclerosis (HP:0007354)3.02742143
25Ependymoma (HP:0002888)3.02452307
26Myokymia (HP:0002411)3.01955137
27Ragged-red muscle fibers (HP:0003200)2.99569063
28Pointed chin (HP:0000307)2.94952720
29Insomnia (HP:0100785)2.86999275
30Interstitial pulmonary disease (HP:0006530)2.86765214
31Abnormality of the astrocytes (HP:0100707)2.84646875
32Astrocytoma (HP:0009592)2.84646875
33Mediastinal lymphadenopathy (HP:0100721)2.84331660
34Autoimmune thrombocytopenia (HP:0001973)2.78898031
35Elfin facies (HP:0004428)2.78634633
36Hypercortisolism (HP:0001578)2.78496316
37Shoulder girdle muscle weakness (HP:0003547)2.75978992
38Cellulitis (HP:0100658)2.74497230
39Obstructive lung disease (HP:0006536)2.72433074
40Chronic obstructive pulmonary disease (HP:0006510)2.72433074
41Pelvic girdle muscle weakness (HP:0003749)2.66735714
42Hepatosplenomegaly (HP:0001433)2.63626196
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.62400173
44Visual hallucinations (HP:0002367)2.60067193
45Hypertensive crisis (HP:0100735)2.60036623
46Stomatitis (HP:0010280)2.59176104
47Neuronal loss in central nervous system (HP:0002529)2.58931155
48Vacuolated lymphocytes (HP:0001922)2.56433860
49Hand muscle atrophy (HP:0009130)2.54387907
50Nasal polyposis (HP:0100582)2.52733673
51Degeneration of anterior horn cells (HP:0002398)2.51919897
52Abnormality of the anterior horn cell (HP:0006802)2.51919897
53Atrophy/Degeneration involving motor neurons (HP:0007373)2.51127603
54Recurrent gram-negative bacterial infections (HP:0005420)2.48641720
55Annular pancreas (HP:0001734)2.46742858
56Heterotopia (HP:0002282)2.45152912
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.43548503
58Cerebral hypomyelination (HP:0006808)2.42397393
59Severe short stature (HP:0003510)2.40927651
60Cerebral aneurysm (HP:0004944)2.39484185
61Increased IgE level (HP:0003212)2.37518092
62Microvesicular hepatic steatosis (HP:0001414)2.35046383
63Broad distal phalanx of finger (HP:0009836)2.34088959
64Neoplasm of the heart (HP:0100544)2.33623304
65Elevated erythrocyte sedimentation rate (HP:0003565)2.33111026
66Orchitis (HP:0100796)2.29842759
67Growth hormone excess (HP:0000845)2.29509478
68Vertebral arch anomaly (HP:0008438)2.28609857
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.28516595
70Abnormality of the musculature of the pelvis (HP:0001469)2.26572454
71Abnormality of the hip-girdle musculature (HP:0001445)2.26572454
72Type II diabetes mellitus (HP:0005978)2.26390133
73Abnormal rod and cone electroretinograms (HP:0008323)2.25809812
74Abnormality of the motor neurons (HP:0002450)2.22621927
75Abnormal neuron morphology (HP:0012757)2.22621927
76Vertebral compression fractures (HP:0002953)2.21189602
77Progressive neurologic deterioration (HP:0002344)2.21117174
78Upper limb amyotrophy (HP:0009129)2.21012012
79Distal upper limb amyotrophy (HP:0007149)2.21012012
80Ulnar deviation of the wrist (HP:0003049)2.18744004
81Apathy (HP:0000741)2.17911103
82Renovascular hypertension (HP:0100817)2.16015934
83Failure to thrive in infancy (HP:0001531)2.15621263
84Chest pain (HP:0100749)2.15543777
85Difficulty climbing stairs (HP:0003551)2.14996909
86Increased serum ferritin (HP:0003281)2.14793122
87Diminished motivation (HP:0000745)2.14398571
88Ankle clonus (HP:0011448)2.14152970
89Recurrent fungal infections (HP:0002841)2.14078467
90Abnormality of the nasal mucosa (HP:0000433)2.14055620
91Colitis (HP:0002583)2.13610476
92Progressive external ophthalmoplegia (HP:0000590)2.12438961
93Abnormality of the labia minora (HP:0012880)2.11740809
94Abnormality of the periventricular white matter (HP:0002518)2.11019123
95Abnormality of ocular smooth pursuit (HP:0000617)2.10894419
96Impaired smooth pursuit (HP:0007772)2.08755688
97Petechiae (HP:0000967)2.08171634
98Nuclear cataract (HP:0100018)2.07020459
99Supranuclear gaze palsy (HP:0000605)2.06169771
100Peripheral hypomyelination (HP:0007182)2.05820901
101Cervical subluxation (HP:0003308)2.05786397
102Meningitis (HP:0001287)2.05493110
103Gastrointestinal inflammation (HP:0004386)2.05076379
104Recurrent skin infections (HP:0001581)2.02879661
105Glioma (HP:0009733)2.02448171
106Depression (HP:0000716)2.00978517
107Increased nuchal translucency (HP:0010880)2.00850146
108Myopathic facies (HP:0002058)2.00776357
109Increased CSF protein (HP:0002922)1.99595282
110Asymmetric septal hypertrophy (HP:0001670)1.99455495
111Purpura (HP:0000979)1.98456899
112Overriding aorta (HP:0002623)1.98167453
113Gingivitis (HP:0000230)1.98061517
114Exercise-induced myalgia (HP:0003738)1.97364699
115Cholelithiasis (HP:0001081)1.97332358
116Systemic lupus erythematosus (HP:0002725)1.96350397
117Enlarged penis (HP:0000040)1.96164391
118Progressive microcephaly (HP:0000253)1.96064413
119Bowel diverticulosis (HP:0005222)1.94833866
120Renal duplication (HP:0000075)1.94573585
121Easy fatigability (HP:0003388)1.93423561
122Resting tremor (HP:0002322)1.93261133
123Ventricular fibrillation (HP:0001663)1.93078215
124Thrombocytosis (HP:0001894)1.92915538
125Hemiplegia (HP:0002301)1.91740713
126Megalocornea (HP:0000485)1.89736478
127Hypergammaglobulinemia (HP:0010702)1.87441446
128Focal seizures (HP:0007359)1.87068113
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86658279
130Urticaria (HP:0001025)1.86153611
131Recurrent viral infections (HP:0004429)1.85532015
132Mutism (HP:0002300)1.85088703
133Optic neuritis (HP:0100653)1.85037875
134Retrobulbar optic neuritis (HP:0100654)1.85037875
135Abnormality of the fingertips (HP:0001211)1.84837433
136Intellectual disability, profound (HP:0002187)1.83540754
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83455795
138Pendular nystagmus (HP:0012043)1.82898850
139Upper motor neuron abnormality (HP:0002127)1.82854100
140Athetosis (HP:0002305)1.80800220
141Abnormality of iron homeostasis (HP:0011031)1.80480878
142Chronic bronchitis (HP:0004469)1.80294000
143Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80045168
144Generalized hyperpigmentation (HP:0007440)1.79337371
145Prominent nose (HP:0000448)1.79246995
146Polygenic inheritance (HP:0010982)1.79161948
147Axonal loss (HP:0003447)1.79156987
148Action tremor (HP:0002345)1.79112668
149Reticulocytosis (HP:0001923)1.78851695
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78556072
151Striae distensae (HP:0001065)1.78073633
152Colon cancer (HP:0003003)1.76803408
153Granulocytopenia (HP:0001913)1.76450210
154Thoracic kyphosis (HP:0002942)1.76429406
155Arterial thrombosis (HP:0004420)1.76396461
156Amyloidosis (HP:0011034)1.76372590
157Death in childhood (HP:0003819)1.75763644
158Restrictive lung disease (HP:0002091)1.75041896
159Postural instability (HP:0002172)1.74249311
160Achilles tendon contracture (HP:0001771)1.73154498
161Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72734914
162Gastrointestinal infarctions (HP:0005244)1.72640702
163Cutaneous photosensitivity (HP:0000992)1.72129346
164Central scotoma (HP:0000603)1.71707105
165Deep palmar crease (HP:0006191)1.71645377
166Bronchitis (HP:0012387)1.71336001
167Global brain atrophy (HP:0002283)1.70623864
168Personality changes (HP:0000751)1.70459746
169Selective tooth agenesis (HP:0001592)1.70005598
170Inflammation of the large intestine (HP:0002037)1.69543108
171Macroorchidism (HP:0000053)1.68313182
172Truncal obesity (HP:0001956)1.67198415
173Angiofibromas (HP:0010615)1.66771899
174Adenoma sebaceum (HP:0009720)1.66771899
175Recurrent bronchitis (HP:0002837)1.65364001
176Aqueductal stenosis (HP:0002410)1.64889040
177Obsessive-compulsive behavior (HP:0000722)1.64172451
178Long palpebral fissure (HP:0000637)1.62958232
179Menstrual irregularities (HP:0000858)1.62279489
180Truncal ataxia (HP:0002078)1.62166536
181Papilledema (HP:0001085)1.58628527
182Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.58395173
183Truncus arteriosus (HP:0001660)1.57951648
184Ankle contracture (HP:0006466)1.55212498
185Dysmetric saccades (HP:0000641)1.54663794
186Fibroma (HP:0010614)1.54169753
187Lissencephaly (HP:0001339)1.53480314
188Back pain (HP:0003418)1.52224944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.38356037
2EEF2K3.17271068
3NEK13.08739492
4PRPF4B3.08113843
5PRKD32.87035507
6MAP3K92.84239641
7TRIB32.81453050
8SMG12.79082300
9SCYL22.49048937
10PDK42.41913656
11PDK32.41913656
12NEK22.41569786
13MAP3K102.41183365
14TESK12.32313778
15PKN22.29873840
16MAP3K32.08623428
17PIM22.08597393
18TSSK61.94576921
19ICK1.86537306
20NME21.83426239
21TBK11.82429488
22RIPK41.74149174
23MAP3K41.72411155
24TESK21.67794090
25PASK1.61038003
26TAOK21.54298132
27KSR21.53192093
28CAMKK11.52528714
29VRK21.48412740
30JAK31.44465887
31WEE11.43963079
32BRSK11.43244622
33BUB11.41809966
34RET1.41021546
35MAP3K141.39487797
36ALK1.38578591
37CDK121.38267536
38SIK21.38256048
39SIK11.37393243
40TAOK11.37287827
41RIPK11.36562808
42MAP2K41.34890138
43PAK41.34824621
44CAMKK21.33241749
45MAP4K11.31711814
46BCKDK1.31081264
47PTK61.28339947
48TNK21.26299156
49MINK11.25493075
50MARK11.23930808
51CDK191.23225481
52PAK61.20578740
53KSR11.18860479
54DAPK11.18468548
55IRAK41.16786909
56BLK1.15741615
57TYRO31.11644017
58ARAF1.11255041
59IKBKE1.10417183
60PRKD21.10258089
61EPHB11.09273157
62MAP3K11.05052560
63CDC71.02257386
64MAP2K30.99998433
65RPS6KB20.94589825
66LMTK20.90778023
67LRRK20.88812900
68NTRK20.87627180
69RAF10.87309319
70ZAP700.86683604
71STK380.82373342
72PLK10.79840480
73HIPK20.79828543
74EPHA30.79269387
75FGR0.79199600
76ERN10.78592141
77MAP3K110.78199702
78MAPKAPK30.77850413
79CSK0.77848967
80SIK30.77422694
81MTOR0.75718890
82CHUK0.75604890
83IRAK20.74819111
84SYK0.74732350
85MAP3K50.74605333
86RPS6KC10.73331659
87RPS6KL10.73331659
88DAPK20.72463199
89UHMK10.70422454
90AURKA0.70053206
91ATR0.69872713
92MAPK110.69114063
93IKBKB0.68913954
94CDK150.68408703
95CDK180.68354245
96MAP2K70.67373382
97CAMK1D0.67187150
98TGFBR10.65842162
99NTRK30.65167053
100HCK0.64853153
101FES0.63865491
102CDK11A0.62267292
103MAPK120.61834315
104CAMK1G0.61665070
105PTK2B0.61277300
106PDPK10.60869339
107NTRK10.60694604
108MATK0.59966931
109CDC42BPA0.59763298
110JAK20.59108370
111MARK20.58809070
112PNCK0.58543805
113BTK0.58394842
114* CCNB10.58108381
115PIM10.57312177
116CHEK10.56048876
117CDK140.55502999
118PDK20.55357644
119STK240.55354984
120TTN0.55308843
121BMX0.55251370
122ERBB20.55054910
123CDK20.52334938
124RPS6KA60.51915423
125CDK50.51398733
126MAP3K20.51081026
127CAMK10.50722389
128JAK10.49945008
129RPS6KA20.49752389
130DYRK1B0.48750847
131CAMK40.48634028
132PDK10.48573175
133MAP3K80.48267584
134PDGFRA0.47730330
135STK100.46375625
136CSF1R0.45810879
137BRSK20.45760873
138WNK40.45683823
139FGFR40.45548927
140EPHA20.45464358
141TTK0.45426194
142FGFR10.45247869
143TYK20.45043514
144CDK90.44904448
145MAPK150.44452109
146CHEK20.44303816
147MAP2K60.44181880
148IRAK10.43084349
149MAPK40.42998935
150PAK10.41802492
151DYRK30.41575035
152MAP3K60.39294963
153PLK30.38644798
154LIMK10.38444717
155DAPK30.38421289
156MAP3K70.37591779
157GRK60.36823146
158RPS6KA10.34954234
159* MAPK90.34800556
160MAPK80.34683750
161CDK40.33536049
162PRKCH0.32060257

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.77932394
2Phototransduction_Homo sapiens_hsa047442.93482875
3Osteoclast differentiation_Homo sapiens_hsa043802.44112025
4Synaptic vesicle cycle_Homo sapiens_hsa047212.43244758
5Lysosome_Homo sapiens_hsa041422.38263918
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29562344
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28210230
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.24646378
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.03295733
10Oocyte meiosis_Homo sapiens_hsa041141.90226932
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84766716
12Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.81051350
13Leishmaniasis_Homo sapiens_hsa051401.74176459
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71656031
15RNA transport_Homo sapiens_hsa030131.71206584
16DNA replication_Homo sapiens_hsa030301.70936168
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68936309
18Tuberculosis_Homo sapiens_hsa051521.68915099
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64118846
20mTOR signaling pathway_Homo sapiens_hsa041501.63073803
21Spliceosome_Homo sapiens_hsa030401.55947545
22Cell cycle_Homo sapiens_hsa041101.46109854
23Olfactory transduction_Homo sapiens_hsa047401.44849261
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.41054228
25Hepatitis C_Homo sapiens_hsa051601.41012843
26Base excision repair_Homo sapiens_hsa034101.35658027
27TNF signaling pathway_Homo sapiens_hsa046681.35480263
28Colorectal cancer_Homo sapiens_hsa052101.33537056
29Influenza A_Homo sapiens_hsa051641.33381731
30Vibrio cholerae infection_Homo sapiens_hsa051101.32300608
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.31134675
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28793748
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27903675
34Legionellosis_Homo sapiens_hsa051341.27068010
35Phagosome_Homo sapiens_hsa041451.24801363
36Long-term potentiation_Homo sapiens_hsa047201.24190743
37Staphylococcus aureus infection_Homo sapiens_hsa051501.22496722
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21959827
39Herpes simplex infection_Homo sapiens_hsa051681.21161450
40Dopaminergic synapse_Homo sapiens_hsa047281.20962752
41Hepatitis B_Homo sapiens_hsa051611.20340417
42Rheumatoid arthritis_Homo sapiens_hsa053231.19175567
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17296915
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16113191
45Allograft rejection_Homo sapiens_hsa053301.15586127
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14723433
47Pertussis_Homo sapiens_hsa051331.14680022
48Measles_Homo sapiens_hsa051621.13841337
49Type II diabetes mellitus_Homo sapiens_hsa049301.13158756
50Salmonella infection_Homo sapiens_hsa051321.11210787
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10856764
52Alcoholism_Homo sapiens_hsa050341.09575706
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09366328
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09263289
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09228563
56Primary immunodeficiency_Homo sapiens_hsa053401.09011721
57Insulin secretion_Homo sapiens_hsa049111.08734839
58mRNA surveillance pathway_Homo sapiens_hsa030151.07941096
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06709426
60Chronic myeloid leukemia_Homo sapiens_hsa052201.06134836
61Prion diseases_Homo sapiens_hsa050201.05096243
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.04950049
63NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04699431
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04346674
65Toxoplasmosis_Homo sapiens_hsa051451.03925564
66Bladder cancer_Homo sapiens_hsa052191.02765667
67Circadian entrainment_Homo sapiens_hsa047131.02126317
68Sphingolipid signaling pathway_Homo sapiens_hsa040711.01278755
69Endocytosis_Homo sapiens_hsa041441.00887806
70VEGF signaling pathway_Homo sapiens_hsa043701.00134346
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00022017
72Estrogen signaling pathway_Homo sapiens_hsa049150.97745997
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97368559
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95638630
75Malaria_Homo sapiens_hsa051440.95593144
76Biosynthesis of amino acids_Homo sapiens_hsa012300.93056501
77Amphetamine addiction_Homo sapiens_hsa050310.92726576
78Collecting duct acid secretion_Homo sapiens_hsa049660.92230718
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.91990713
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90386055
81Epstein-Barr virus infection_Homo sapiens_hsa051690.90056090
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89261847
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.88622624
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87841505
85GABAergic synapse_Homo sapiens_hsa047270.87711524
86Glucagon signaling pathway_Homo sapiens_hsa049220.87655602
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87512333
88Gastric acid secretion_Homo sapiens_hsa049710.86882516
89Viral carcinogenesis_Homo sapiens_hsa052030.86377581
90B cell receptor signaling pathway_Homo sapiens_hsa046620.85623943
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85348303
92Shigellosis_Homo sapiens_hsa051310.85227421
93Autoimmune thyroid disease_Homo sapiens_hsa053200.83457728
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82285760
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82071176
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81991464
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81652090
98Insulin signaling pathway_Homo sapiens_hsa049100.81642578
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81051991
100Graft-versus-host disease_Homo sapiens_hsa053320.80844818
101Endometrial cancer_Homo sapiens_hsa052130.80591163
102Cholinergic synapse_Homo sapiens_hsa047250.78496459
103* HTLV-I infection_Homo sapiens_hsa051660.77193854
104Hematopoietic cell lineage_Homo sapiens_hsa046400.76869938
105Mismatch repair_Homo sapiens_hsa034300.76231783
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75697481
107Viral myocarditis_Homo sapiens_hsa054160.75421620
108Gap junction_Homo sapiens_hsa045400.74902248
109Type I diabetes mellitus_Homo sapiens_hsa049400.74026506
110Glioma_Homo sapiens_hsa052140.72715397
111Oxytocin signaling pathway_Homo sapiens_hsa049210.72074677
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70911012
113N-Glycan biosynthesis_Homo sapiens_hsa005100.70769469
114Inositol phosphate metabolism_Homo sapiens_hsa005620.70558344
115Prolactin signaling pathway_Homo sapiens_hsa049170.70262683
116Pancreatic cancer_Homo sapiens_hsa052120.70127627
117HIF-1 signaling pathway_Homo sapiens_hsa040660.69765332
118Notch signaling pathway_Homo sapiens_hsa043300.68943209
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68568053
120Non-small cell lung cancer_Homo sapiens_hsa052230.67040724
121Carbon metabolism_Homo sapiens_hsa012000.66649186
122MAPK signaling pathway_Homo sapiens_hsa040100.65788282
123Insulin resistance_Homo sapiens_hsa049310.64633897
124Sulfur relay system_Homo sapiens_hsa041220.64574811
125Morphine addiction_Homo sapiens_hsa050320.64539782
126T cell receptor signaling pathway_Homo sapiens_hsa046600.64396031
127Systemic lupus erythematosus_Homo sapiens_hsa053220.64149620
128African trypanosomiasis_Homo sapiens_hsa051430.63886956
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63516105
130Chemokine signaling pathway_Homo sapiens_hsa040620.63348288
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62907239
132Pentose phosphate pathway_Homo sapiens_hsa000300.61474110
133Dorso-ventral axis formation_Homo sapiens_hsa043200.61453401
134GnRH signaling pathway_Homo sapiens_hsa049120.61177574
135Salivary secretion_Homo sapiens_hsa049700.60736723
136Apoptosis_Homo sapiens_hsa042100.60344871
137Acute myeloid leukemia_Homo sapiens_hsa052210.59691718
138Sphingolipid metabolism_Homo sapiens_hsa006000.59560874
139Arginine biosynthesis_Homo sapiens_hsa002200.59097055
140Antigen processing and presentation_Homo sapiens_hsa046120.58941213
141Glutamatergic synapse_Homo sapiens_hsa047240.57532003
142Galactose metabolism_Homo sapiens_hsa000520.57244254
143Hippo signaling pathway_Homo sapiens_hsa043900.57009938
144AMPK signaling pathway_Homo sapiens_hsa041520.56879474
145Cocaine addiction_Homo sapiens_hsa050300.56641574
1462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54891304
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.54325586
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.54130391
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.53878012
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52923684
151ErbB signaling pathway_Homo sapiens_hsa040120.52562640
152Nicotine addiction_Homo sapiens_hsa050330.52112455
153AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52062805
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51954738
155Wnt signaling pathway_Homo sapiens_hsa043100.51606219
156Renal cell carcinoma_Homo sapiens_hsa052110.50491976
157Fructose and mannose metabolism_Homo sapiens_hsa000510.50433960

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