KAT6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)4.62027871
2regulation of B cell receptor signaling pathway (GO:0050855)4.26922187
3mitotic sister chromatid cohesion (GO:0007064)4.25647606
4activated T cell proliferation (GO:0050798)3.95105220
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87401442
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.84534217
7pre-miRNA processing (GO:0031054)3.83231922
8histone H3-K4 trimethylation (GO:0080182)3.81571828
9positive regulation of granulocyte differentiation (GO:0030854)3.78998274
10regulation of RNA export from nucleus (GO:0046831)3.71030914
11histone H3-K36 demethylation (GO:0070544)3.67211388
12nuclear pore complex assembly (GO:0051292)3.65887249
13histone H3-K4 methylation (GO:0051568)3.50458493
14response to interleukin-15 (GO:0070672)3.40900575
15positive regulation of histone deacetylation (GO:0031065)3.35880127
16interferon-gamma production (GO:0032609)3.34571216
17NLS-bearing protein import into nucleus (GO:0006607)3.29457264
18nuclear pore organization (GO:0006999)3.23685981
19negative regulation of T cell mediated immunity (GO:0002710)3.21934163
20negative regulation of histone methylation (GO:0031061)3.21282066
21regulation of nucleobase-containing compound transport (GO:0032239)3.21094354
22glucocorticoid receptor signaling pathway (GO:0042921)3.17325186
23cellular response to interleukin-15 (GO:0071350)3.12352024
24tolerance induction (GO:0002507)3.12339795
25leukocyte aggregation (GO:0070486)3.07965307
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.06032478
27negative regulation of cell killing (GO:0031342)3.06032478
28alpha-beta T cell differentiation (GO:0046632)3.04691276
29B cell receptor signaling pathway (GO:0050853)3.04509664
30histone H3-K9 demethylation (GO:0033169)3.04266210
31positive thymic T cell selection (GO:0045059)2.99970552
32peptidyl-lysine trimethylation (GO:0018023)2.96948492
33corticosteroid receptor signaling pathway (GO:0031958)2.95257556
34histone lysine demethylation (GO:0070076)2.92739049
35histone lysine methylation (GO:0034968)2.90370505
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89741798
37regulation of gamma-delta T cell differentiation (GO:0045586)2.89609801
38negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88880216
39negative regulation of translation, ncRNA-mediated (GO:0040033)2.88880216
40regulation of translation, ncRNA-mediated (GO:0045974)2.88880216
41pore complex assembly (GO:0046931)2.88591794
42positive regulation of gamma-delta T cell activation (GO:0046645)2.87966767
43negative regulation of lymphocyte mediated immunity (GO:0002707)2.87744857
44nucleus localization (GO:0051647)2.87688260
45positive regulation of gene expression, epigenetic (GO:0045815)2.86113245
46alpha-beta T cell activation (GO:0046631)2.85330559
47regulation of histone H3-K27 methylation (GO:0061085)2.84115976
48regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.82523636
49positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.82523636
50definitive hemopoiesis (GO:0060216)2.81739114
51positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.80754325
52regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.80754325
53negative regulation of erythrocyte differentiation (GO:0045647)2.80575972
54positive T cell selection (GO:0043368)2.77863282
55RNA stabilization (GO:0043489)2.77314075
56mRNA stabilization (GO:0048255)2.77314075
57negative T cell selection (GO:0043383)2.75673859
58T-helper cell differentiation (GO:0042093)2.74268361
59CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74268361
60histone demethylation (GO:0016577)2.73355415
61T cell migration (GO:0072678)2.71030471
62stress granule assembly (GO:0034063)2.71005097
63thymic T cell selection (GO:0045061)2.70633836
64negative thymic T cell selection (GO:0045060)2.69923367
65regulation of granulocyte differentiation (GO:0030852)2.68987941
66negative regulation of T-helper cell differentiation (GO:0045623)2.68434009
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68434009
68positive regulation by symbiont of host defense response (GO:0052509)2.68428734
69modulation by symbiont of host defense response (GO:0052031)2.68428734
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.68428734
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.68428734
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.68428734
73modulation by symbiont of host immune response (GO:0052553)2.68428734
74cellular extravasation (GO:0045123)2.67181931
75embryonic retina morphogenesis in camera-type eye (GO:0060059)2.67038974
76response to muramyl dipeptide (GO:0032495)2.66604742
77growth hormone receptor signaling pathway (GO:0060396)2.65491821
78regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.65314394
79CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.63846297
80T cell selection (GO:0045058)2.62924117
81negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.62126561
82histone H3-K9 methylation (GO:0051567)2.61999816
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.60410097
84regulation of gamma-delta T cell activation (GO:0046643)2.60165157
85negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.60037795
86histone H3-K9 modification (GO:0061647)2.59793634
87positive regulation of mRNA catabolic process (GO:0061014)2.59256805
88regulation of alpha-beta T cell proliferation (GO:0046640)2.58966109
89establishment of protein localization to Golgi (GO:0072600)2.58611954
90regulation of isotype switching to IgG isotypes (GO:0048302)2.57887913
91peptidyl-lysine dimethylation (GO:0018027)2.56493679
92protein K48-linked deubiquitination (GO:0071108)2.56161762
93regulation of regulatory T cell differentiation (GO:0045589)2.55577828
94antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54615886
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53762833
96microglial cell activation (GO:0001774)2.51787219
97cerebellar Purkinje cell differentiation (GO:0021702)2.51005190
98regulation of mRNA catabolic process (GO:0061013)2.50463311
99histone H4-K16 acetylation (GO:0043984)2.50189359
100cellular response to ethanol (GO:0071361)2.50062960
101antigen processing and presentation of endogenous antigen (GO:0019883)2.50000255
102regulation of interleukin-12 biosynthetic process (GO:0045075)2.49625471
103hippo signaling (GO:0035329)2.49561947
104T cell differentiation (GO:0030217)2.47488457
105macrophage activation involved in immune response (GO:0002281)2.46529522
106regulation of B cell differentiation (GO:0045577)2.45865152
107protein demethylation (GO:0006482)2.44559608
108protein dealkylation (GO:0008214)2.44559608
109peptidyl-lysine methylation (GO:0018022)2.44519814
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44481861
111T cell homeostasis (GO:0043029)2.44313142
112B cell homeostasis (GO:0001782)2.44251968
113regulation of DNA endoreduplication (GO:0032875)2.42957176
114positive regulation of alpha-beta T cell proliferation (GO:0046641)2.42942278
115regulation of NFAT protein import into nucleus (GO:0051532)2.37839988
116embryonic camera-type eye morphogenesis (GO:0048596)2.37429766
117monoubiquitinated protein deubiquitination (GO:0035520)2.36164025
118histone methylation (GO:0016571)2.35413825
119coronary vasculature morphogenesis (GO:0060977)2.33927652
120peptidyl-threonine phosphorylation (GO:0018107)2.31486754
121germ cell migration (GO:0008354)2.29878384
122histone H2A monoubiquitination (GO:0035518)2.29374901
123nucleosome disassembly (GO:0006337)2.27910411
124protein-DNA complex disassembly (GO:0032986)2.27910411
125positive regulation by host of viral transcription (GO:0043923)2.26480815
126regulation of protein polyubiquitination (GO:1902914)2.25895109
127cellular response to growth hormone stimulus (GO:0071378)2.25157398
128peptidyl-threonine modification (GO:0018210)2.24323407
129regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.23778501
130gene silencing (GO:0016458)2.23370145
131intracellular estrogen receptor signaling pathway (GO:0030520)2.22608502
132positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.21903999
133regulation of sister chromatid cohesion (GO:0007063)2.20574049
134histone mRNA catabolic process (GO:0071044)2.20473339
135regulation of histone deacetylation (GO:0031063)2.20332511
136gene silencing by RNA (GO:0031047)2.18930597
137interkinetic nuclear migration (GO:0022027)2.18642105
138regulation of protein deacetylation (GO:0090311)2.18494315
139mitotic chromosome condensation (GO:0007076)2.18377159
140protein localization to endosome (GO:0036010)2.18067008
141dosage compensation (GO:0007549)2.17595180
142positive regulation of protein deacetylation (GO:0090312)2.15949763
143establishment of nucleus localization (GO:0040023)2.15752144
144regulation of mRNA stability (GO:0043488)2.15198933
145regulation of histone H3-K9 methylation (GO:0051570)2.15159149
146cortical actin cytoskeleton organization (GO:0030866)2.14449665
147positive regulation of RNA splicing (GO:0033120)2.13393388
148regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.12662132
149regulation of T cell tolerance induction (GO:0002664)2.12104368
150retrograde transport, vesicle recycling within Golgi (GO:0000301)2.11997924
151negative regulation of histone modification (GO:0031057)2.10769135
152alternative mRNA splicing, via spliceosome (GO:0000380)2.09845670
153negative regulation of granulocyte differentiation (GO:0030853)2.06999163
154regulation of histone methylation (GO:0031060)2.04845984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.31967545
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.13145230
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.06012728
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69966122
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.32440463
6MYC_22102868_ChIP-Seq_BL_Human3.28994033
7E2F7_22180533_ChIP-Seq_HELA_Human3.08152438
8TCF7_22412390_ChIP-Seq_EML_Mouse2.48849777
9KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.42006113
10KDM2B_26808549_Chip-Seq_DND41_Human2.34024997
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.18807348
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17480795
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16429526
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13800869
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09505758
16RUNX_20019798_ChIP-Seq_JUKART_Human2.06648355
17DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.03053328
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02576705
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.00550397
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.99986199
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99530856
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.89475241
23TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.88266213
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82888237
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81032603
26VDR_21846776_ChIP-Seq_THP-1_Human1.79711681
27FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.73625858
28ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72355259
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71826059
30UTX_26944678_Chip-Seq_JUKART_Human1.68636790
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66213509
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63680006
33SCL_19346495_ChIP-Seq_HPC-7_Human1.62690547
34MAF_26560356_Chip-Seq_TH1_Human1.62524733
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62218161
36KDM2B_26808549_Chip-Seq_K562_Human1.53002921
37EZH2_22144423_ChIP-Seq_EOC_Human1.50925900
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49440181
39MYB_26560356_Chip-Seq_TH2_Human1.45682457
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45533137
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45513388
42MYB_26560356_Chip-Seq_TH1_Human1.43645350
43PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43178406
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40566560
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40020376
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.39579368
47AR_21572438_ChIP-Seq_LNCaP_Human1.38442414
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38152838
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.38103809
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37433279
51SPI1_23127762_ChIP-Seq_K562_Human1.35197567
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.33896526
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33467447
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.33425493
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32233993
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30233436
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29776332
58GATA1_22025678_ChIP-Seq_K562_Human1.28811681
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28415930
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26974772
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26254953
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25920901
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.24218266
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23952493
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23873521
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23465819
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23113273
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23024104
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22875060
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21684869
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.20795379
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.20313507
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20184439
74GBX2_23144817_ChIP-Seq_PC3_Human1.18932418
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18165442
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17801355
77VDR_24763502_ChIP-Seq_THP-1_Human1.17547880
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17426481
79TP53_16413492_ChIP-PET_HCT116_Human1.16881477
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15575687
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15575687
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.14669433
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14245593
84STAT3_23295773_ChIP-Seq_U87_Human1.14221601
85AHR_22903824_ChIP-Seq_MCF-7_Human1.12017340
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.11846759
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09704464
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09338016
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07227974
90GATA3_27048872_Chip-Seq_THYMUS_Human1.07083438
91RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06389948
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05029221
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04657767
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04025510
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03395117
96* BRD4_25478319_ChIP-Seq_HGPS_Human1.03366095
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03097669
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.02494455
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02378099
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01873414
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01735920
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01105523
103NCOR1_26117541_ChIP-Seq_K562_Human1.00757616
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00756860
105GATA2_19941826_ChIP-Seq_K562_Human0.99898329
106TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99813728
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99630493
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.98997777
109TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98139225
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.98009335
111TCF4_23295773_ChIP-Seq_U87_Human0.97000928
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.96780011
113* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96360450
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.96234134
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96048339
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95549160
117SMAD4_21799915_ChIP-Seq_A2780_Human0.95517055
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95315406
119GATA3_26560356_Chip-Seq_TH2_Human0.94895094
120GATA1_19941826_ChIP-Seq_K562_Human0.94866231
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94622078
122* CIITA_25753668_ChIP-Seq_RAJI_Human0.94496421
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94293549
124PU_27001747_Chip-Seq_BMDM_Mouse0.93363523
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93331007
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93186293
127VDR_24787735_ChIP-Seq_THP-1_Human0.92836660
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.92721264
129E2F1_21310950_ChIP-Seq_MCF-7_Human0.91963402
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91912249
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90892242
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.90427326
133DROSHA_22980978_ChIP-Seq_HELA_Human0.89684265
134SMRT_27268052_Chip-Seq_Bcells_Human0.89296229
135CLOCK_20551151_ChIP-Seq_293T_Human0.89005051
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.88626776
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.88626776
138ER_23166858_ChIP-Seq_MCF-7_Human0.88360471
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.88286179
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87683877
141GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87233131
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.87036523
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.86658968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.94106739
2MP0005076_abnormal_cell_differentiation3.28129607
3MP0003300_gastrointestinal_ulcer3.08731101
4MP0003724_increased_susceptibility_to2.88267857
5MP0010352_gastrointestinal_tract_polyps2.85751484
6MP0004381_abnormal_hair_follicle2.77788379
7MP0003705_abnormal_hypodermis_morpholog2.34991509
8MP0003303_peritoneal_inflammation2.14731408
9MP0002166_altered_tumor_susceptibility2.14046847
10MP0009278_abnormal_bone_marrow2.10200011
11MP0004808_abnormal_hematopoietic_stem2.06396895
12MP0002396_abnormal_hematopoietic_system2.05110125
13MP0003787_abnormal_imprinting2.02747340
14MP0000733_abnormal_muscle_development2.02440002
15MP0005409_darkened_coat_color2.00724150
16MP0003045_fibrosis1.98779634
17MP0004130_abnormal_muscle_cell1.98571803
18MP0008961_abnormal_basal_metabolism1.85585868
19MP0003436_decreased_susceptibility_to1.82765968
20MP0001849_ear_inflammation1.72273114
21MP0003866_abnormal_defecation1.71284804
22MP0005000_abnormal_immune_tolerance1.69790994
23MP0003763_abnormal_thymus_physiology1.68928601
24MP0010307_abnormal_tumor_latency1.60047998
25MP0000703_abnormal_thymus_morphology1.52612756
26MP0001851_eye_inflammation1.51002749
27MP0003828_pulmonary_edema1.50936450
28MP0002006_tumorigenesis1.50745920
29MP0008057_abnormal_DNA_replication1.50037470
30MP0004185_abnormal_adipocyte_glucose1.47668774
31MP0000428_abnormal_craniofacial_morphol1.46638372
32MP0002877_abnormal_melanocyte_morpholog1.43521824
33MP0001800_abnormal_humoral_immune1.43483571
34MP0003091_abnormal_cell_migration1.42161371
35MP0005174_abnormal_tail_pigmentation1.41746542
36MP0001873_stomach_inflammation1.40350866
37MP0002925_abnormal_cardiovascular_devel1.36269721
38MP0003984_embryonic_growth_retardation1.36163044
39MP0002088_abnormal_embryonic_growth/wei1.34373500
40MP0000015_abnormal_ear_pigmentation1.34165783
41MP0003121_genomic_imprinting1.33592845
42MP0003566_abnormal_cell_adhesion1.32765063
43MP0002009_preneoplasia1.31382927
44MP0005387_immune_system_phenotype1.31278649
45MP0001790_abnormal_immune_system1.31278649
46MP0002398_abnormal_bone_marrow1.31155103
47MP0002419_abnormal_innate_immunity1.30140080
48MP0005025_abnormal_response_to1.28744302
49MP0003935_abnormal_craniofacial_develop1.27745631
50MP0004197_abnormal_fetal_growth/weight/1.27471422
51MP0002086_abnormal_extraembryonic_tissu1.25028052
52MP0001915_intracranial_hemorrhage1.24959074
53MP0002084_abnormal_developmental_patter1.24667036
54MP0001672_abnormal_embryogenesis/_devel1.23248835
55MP0005380_embryogenesis_phenotype1.23248835
56MP0000350_abnormal_cell_proliferation1.20750669
57MP0005464_abnormal_platelet_physiology1.19691282
58MP0002429_abnormal_blood_cell1.17350382
59MP0000465_gastrointestinal_hemorrhage1.17321627
60MP0003890_abnormal_embryonic-extraembry1.16231296
61MP0008877_abnormal_DNA_methylation1.15764398
62MP0001835_abnormal_antigen_presentation1.15338617
63MP0004883_abnormal_blood_vessel1.13442927
64MP0005671_abnormal_response_to1.13106357
65MP0003656_abnormal_erythrocyte_physiolo1.12418612
66MP0003172_abnormal_lysosome_physiology1.11342383
67MP0004510_myositis1.10610048
68MP0009115_abnormal_fat_cell1.10549071
69MP0000685_abnormal_immune_system1.09809124
70MP0002085_abnormal_embryonic_tissue1.09318623
71MP0010630_abnormal_cardiac_muscle1.08914862
72MP0009053_abnormal_anal_canal1.08313845
73MP0000383_abnormal_hair_follicle1.08032567
74MP0002092_abnormal_eye_morphology1.07693825
75MP0001730_embryonic_growth_arrest1.07562436
76MP0003115_abnormal_respiratory_system1.07323227
77MP0009703_decreased_birth_body1.07176814
78MP0002452_abnormal_antigen_presenting1.05942413
79MP0010155_abnormal_intestine_physiology1.05478465
80MP0010678_abnormal_skin_adnexa1.02624254
81MP0005075_abnormal_melanosome_morpholog1.02127797
82MP0005248_abnormal_Harderian_gland1.01194222
83MP0010234_abnormal_vibrissa_follicle1.00497657
84MP0000432_abnormal_head_morphology0.99956185
85MP0000716_abnormal_immune_system0.98227852
86MP0000767_abnormal_smooth_muscle0.98149234
87MP0003077_abnormal_cell_cycle0.98119974
88MP0005397_hematopoietic_system_phenotyp0.97924703
89MP0001545_abnormal_hematopoietic_system0.97924703
90MP0002420_abnormal_adaptive_immunity0.96533503
91MP0000537_abnormal_urethra_morphology0.96320177
92MP0002928_abnormal_bile_duct0.96204124
93MP0005257_abnormal_intraocular_pressure0.95659748
94MP0001784_abnormal_fluid_regulation0.94826860
95MP0001819_abnormal_immune_cell0.94573983
96MP0004947_skin_inflammation0.94307873
97MP0004264_abnormal_extraembryonic_tissu0.94213188
98MP0002722_abnormal_immune_system0.94210238
99MP0008007_abnormal_cellular_replicative0.93998785
100MP0001697_abnormal_embryo_size0.93640761
101MP0002697_abnormal_eye_size0.93113992
102MP0005623_abnormal_meninges_morphology0.92291510
103MP0003111_abnormal_nucleus_morphology0.90403613
104MP0000266_abnormal_heart_morphology0.90048437
105MP0001293_anophthalmia0.90044554
106MP0003385_abnormal_body_wall0.90003230
107MP0010368_abnormal_lymphatic_system0.88461616
108MP0005023_abnormal_wound_healing0.88368990
109MP0000003_abnormal_adipose_tissue0.86633060
110MP0010094_abnormal_chromosome_stability0.86102596
111MP0002998_abnormal_bone_remodeling0.85945523
112MP0005187_abnormal_penis_morphology0.84780932
113MP0002723_abnormal_immune_serum0.83602942
114MP0002405_respiratory_system_inflammati0.83497878
115MP0003183_abnormal_peptide_metabolism0.83390156
116MP0009333_abnormal_splenocyte_physiolog0.82381789
117MP0008995_early_reproductive_senescence0.82315138
118MP0000689_abnormal_spleen_morphology0.82169092
119MP0001299_abnormal_eye_distance/0.82162990
120MP0000427_abnormal_hair_cycle0.80452228
121MP0003690_abnormal_glial_cell0.80318978
122MP0003567_abnormal_fetal_cardiomyocyte0.80004487
123MP0001879_abnormal_lymphatic_vessel0.79902488
124MP0005310_abnormal_salivary_gland0.79388222
125MP0005666_abnormal_adipose_tissue0.79124247
126MP0003448_altered_tumor_morphology0.78602159
127MP0005375_adipose_tissue_phenotype0.78451178
128MP0009672_abnormal_birth_weight0.77980512
129MP0003755_abnormal_palate_morphology0.76474287
130MP0001348_abnormal_lacrimal_gland0.76209245
131MP0004134_abnormal_chest_morphology0.71165995
132MP0001845_abnormal_inflammatory_respons0.70865694
133MP0003943_abnormal_hepatobiliary_system0.69800879
134MP0000778_abnormal_nervous_system0.68258074
135MP0001502_abnormal_circadian_rhythm0.66861579
136MP0002138_abnormal_hepatobiliary_system0.64610115
137MP0004142_abnormal_muscle_tone0.61615924
138MP0000470_abnormal_stomach_morphology0.58449689
139MP0002168_other_aberrant_phenotype0.57258089
140MP0001533_abnormal_skeleton_physiology0.55816794
141MP0004484_altered_response_of0.55463072
142MP0000371_diluted_coat_color0.55148007
143MP0002095_abnormal_skin_pigmentation0.51802089
144MP0003632_abnormal_nervous_system0.51454179
145MP0008260_abnormal_autophagy0.51345793
146MP0000377_abnormal_hair_follicle0.50538581
147MP0001663_abnormal_digestive_system0.50363903
148MP0005621_abnormal_cell_physiology0.50278356
149MP0004885_abnormal_endolymph0.49739081

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.32425188
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.48435628
3Short 4th metacarpal (HP:0010044)3.48435628
4Volvulus (HP:0002580)3.35325236
5Macroorchidism (HP:0000053)3.29411602
6Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.16710643
7Eczematoid dermatitis (HP:0000976)3.10596598
8Spontaneous hematomas (HP:0007420)3.00654356
9Long eyelashes (HP:0000527)2.96828755
10Stomatitis (HP:0010280)2.87679731
11Narrow palate (HP:0000189)2.76287384
12Trigonocephaly (HP:0000243)2.67931935
13Cerebral aneurysm (HP:0004944)2.64257311
14Abnormality of the 4th metacarpal (HP:0010012)2.56543154
15Urethral obstruction (HP:0000796)2.55553506
16Hyperacusis (HP:0010780)2.52505954
17Shallow orbits (HP:0000586)2.50330852
18Neonatal hypoglycemia (HP:0001998)2.45132085
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.43147078
20Heterotopia (HP:0002282)2.39197190
21Recurrent bacterial skin infections (HP:0005406)2.38655548
22Prolonged bleeding time (HP:0003010)2.35381891
23Aortic aneurysm (HP:0004942)2.34103053
24Papilledema (HP:0001085)2.28972839
25Lip pit (HP:0100267)2.25925584
26Abnormality of incisor morphology (HP:0011063)2.24330236
27Optic neuritis (HP:0100653)2.23043374
28Retrobulbar optic neuritis (HP:0100654)2.23043374
29Increased nuchal translucency (HP:0010880)2.19933566
30Autoimmune hemolytic anemia (HP:0001890)2.18201632
31Gastrointestinal infarctions (HP:0005244)2.16512029
32Subacute progressive viral hepatitis (HP:0006572)2.15406482
33Abnormality of the columella (HP:0009929)2.14470711
34Transitional cell carcinoma of the bladder (HP:0006740)2.12721690
35Obstructive sleep apnea (HP:0002870)2.12625513
36Abnormality of T cells (HP:0002843)2.12274615
37Truncal obesity (HP:0001956)2.11664926
38Elevated erythrocyte sedimentation rate (HP:0003565)2.10388369
39Leukocytosis (HP:0001974)2.09170075
40Broad thumb (HP:0011304)2.05976835
41Abnormality of eosinophils (HP:0001879)2.05777787
42Obsessive-compulsive behavior (HP:0000722)2.05731719
43Progressive cerebellar ataxia (HP:0002073)2.04401571
44Absent frontal sinuses (HP:0002688)2.03666750
45Myositis (HP:0100614)2.03583499
46Recurrent cutaneous fungal infections (HP:0011370)2.03578048
47Chronic mucocutaneous candidiasis (HP:0002728)2.03578048
48Neoplasm of the tracheobronchial system (HP:0100552)2.02934983
49Abnormality of the nasal septum (HP:0000419)2.02602018
50Severe combined immunodeficiency (HP:0004430)2.01328556
51Hematochezia (HP:0002573)2.00933770
52Cutis marmorata (HP:0000965)2.00226554
53Elfin facies (HP:0004428)1.99919801
54Recurrent abscess formation (HP:0002722)1.97188748
55Thick eyebrow (HP:0000574)1.96799910
56Abnormality of the astrocytes (HP:0100707)1.95252206
57Astrocytoma (HP:0009592)1.95252206
58Leiomyosarcoma (HP:0100243)1.94722394
59Uterine leiomyosarcoma (HP:0002891)1.94722394
60Vertebral arch anomaly (HP:0008438)1.94684523
61Germ cell neoplasia (HP:0100728)1.94216266
62Gingival bleeding (HP:0000225)1.93764507
63Increased density of long bones (HP:0006392)1.93193208
64Supernumerary ribs (HP:0005815)1.93109131
65Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.92493348
66Tapered finger (HP:0001182)1.92255544
67Stomach cancer (HP:0012126)1.92127178
68Abnormality of the intervertebral disk (HP:0005108)1.91645010
69Prominent nose (HP:0000448)1.91565697
70Disproportionate tall stature (HP:0001519)1.91215511
71Orchitis (HP:0100796)1.90660647
72Mitral valve prolapse (HP:0001634)1.90307060
73Recurrent viral infections (HP:0004429)1.89042575
74Bladder carcinoma (HP:0002862)1.88871414
75Bladder neoplasm (HP:0009725)1.88871414
76Dysmetric saccades (HP:0000641)1.88643379
77Gastrointestinal carcinoma (HP:0002672)1.88615452
78Malignant gastrointestinal tract tumors (HP:0006749)1.88615452
79Renovascular hypertension (HP:0100817)1.88102223
80Papillary thyroid carcinoma (HP:0002895)1.85528253
81Hypoplastic iliac wings (HP:0002866)1.84944042
82Limited elbow extension (HP:0001377)1.84273770
83Thyroiditis (HP:0100646)1.83138046
84Gingivitis (HP:0000230)1.83060927
85Renal duplication (HP:0000075)1.82982315
86Tented upper lip vermilion (HP:0010804)1.82882947
87Low anterior hairline (HP:0000294)1.82370811
88T lymphocytopenia (HP:0005403)1.82177942
89Submucous cleft hard palate (HP:0000176)1.81982313
90Deep philtrum (HP:0002002)1.81751810
91Deviation of the thumb (HP:0009603)1.81052200
92Chest pain (HP:0100749)1.80974987
93Spinal cord lesions (HP:0100561)1.80923426
94Syringomyelia (HP:0003396)1.80923426
95Slow saccadic eye movements (HP:0000514)1.80899795
96Eosinophilia (HP:0001880)1.79958301
97Abnormal hair whorl (HP:0010721)1.77075387
98Dislocated radial head (HP:0003083)1.76730436
99Aqueductal stenosis (HP:0002410)1.76662840
100Proximal placement of thumb (HP:0009623)1.76259199
101Hypochromic microcytic anemia (HP:0004840)1.75721650
102Ectopic kidney (HP:0000086)1.74271719
103Increased IgE level (HP:0003212)1.73942063
104Widely spaced teeth (HP:0000687)1.72839087
105Keratoconjunctivitis sicca (HP:0001097)1.72797116
106Curly hair (HP:0002212)1.71854897
107Abnormality of the distal phalanx of the thumb (HP:0009617)1.70466499
108Aneurysm (HP:0002617)1.70440282
109Abnormality of the left ventricular outflow tract (HP:0011103)1.70006714
110Subaortic stenosis (HP:0001682)1.70006714
111Encephalitis (HP:0002383)1.69858373
112Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68593775
113Oligodontia (HP:0000677)1.68590998
114Abnormality of the radial head (HP:0003995)1.68397246
115Bicuspid aortic valve (HP:0001647)1.68106653
116Arterial thrombosis (HP:0004420)1.68070516
117Abnormality of T cell number (HP:0011839)1.67655694
118Smooth philtrum (HP:0000319)1.66995721
119Recurrent bronchitis (HP:0002837)1.66460537
120Hyperventilation (HP:0002883)1.66110710
121Anal stenosis (HP:0002025)1.65816095
122Skin tags (HP:0010609)1.65654977
123Persistence of primary teeth (HP:0006335)1.65240632
124Hypoplastic labia majora (HP:0000059)1.65218324
125Genetic anticipation (HP:0003743)1.65193520
126Overgrowth (HP:0001548)1.65069892
127Vasculitis (HP:0002633)1.65023433
128Skull defect (HP:0001362)1.64852228
129Recurrent skin infections (HP:0001581)1.64286607
130Epistaxis (HP:0000421)1.64126339
131Abnormality of the parietal bone (HP:0002696)1.63378871
132Inflammation of the large intestine (HP:0002037)1.63306467
133Ulnar bowing (HP:0003031)1.63270385
134Midline defect of the nose (HP:0004122)1.63198683
135Arterial tortuosity (HP:0005116)1.62845467
136Panhypogammaglobulinemia (HP:0003139)1.62054556
137Broad phalanges of the hand (HP:0009768)1.61655352
138Spondylolisthesis (HP:0003302)1.61588182
139Overriding aorta (HP:0002623)1.61514814
140Broad palm (HP:0001169)1.60922225
141Ependymoma (HP:0002888)1.60751237
142Hypoplasia of the maxilla (HP:0000327)1.60107711
143Colitis (HP:0002583)1.59890387
144Sandal gap (HP:0001852)1.57868049
145Rectal prolapse (HP:0002035)1.57357423
146Pseudobulbar signs (HP:0002200)1.57195765
147Neoplasm of the oral cavity (HP:0100649)1.57038101
148Depressed nasal tip (HP:0000437)1.56280618
149Bowel diverticulosis (HP:0005222)1.53782019
150Cellulitis (HP:0100658)1.52888304
151Supernumerary bones of the axial skeleton (HP:0009144)1.52378806
152Acute myeloid leukemia (HP:0004808)1.51978677
153Pointed chin (HP:0000307)1.51902145
154Abnormality of the diencephalon (HP:0010662)1.50328001
155Recurrent fungal infections (HP:0002841)1.49232796
156Ureteral obstruction (HP:0006000)1.49216054
157Broad finger (HP:0001500)1.49132928
158Abnormality of chromosome segregation (HP:0002916)1.49073203
159Viral hepatitis (HP:0006562)1.47442647
160Glioma (HP:0009733)1.47441701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.30044201
2CAMK1D2.76191150
3CAMK1G2.73138106
4MAP3K102.70655363
5LATS12.65971105
6EEF2K2.64284162
7NLK2.40123978
8RIPK12.07990105
9BRD42.03157225
10MAP4K12.00069162
11RIPK41.99701979
12TRIB31.95773274
13STK101.92123315
14FGFR31.82358047
15SIK21.78137344
16DMPK1.76680125
17AKT31.72188243
18TGFBR21.60555080
19PRPF4B1.60370408
20BTK1.57442946
21SIK11.57339481
22PKN21.55913968
23FES1.55604203
24ICK1.47717475
25MTOR1.45108985
26TEC1.45057388
27PTK61.39958750
28SGK2231.37459371
29SGK4941.37459371
30PDGFRB1.36966679
31PDGFRA1.36021438
32CDC71.35551044
33JAK11.35013665
34STK31.33075774
35CDK61.30142262
36IKBKE1.27358984
37MAP3K141.27140613
38TTN1.23236697
39FGFR21.19823560
40FGFR41.18806904
41IRAK11.17450494
42TNIK1.17221377
43YES11.15657346
44CDK91.13554404
45NEK21.13037275
46EPHB11.12940051
47SYK1.12557096
48WNK11.11635324
49ALK1.10410411
50BLK1.09985480
51SGK31.08835416
52CSF1R1.07515418
53TYK21.04675032
54CHUK1.04526602
55PASK1.03496487
56EPHA31.02279399
57CAMKK11.01862090
58JAK30.98888385
59IRAK40.97255484
60MAP3K20.96802699
61MAP3K130.95979022
62NUAK10.95073757
63HIPK20.94112308
64ITK0.93189434
65MAP2K30.91826908
66TYRO30.91221310
67TAOK10.90447864
68CAMKK20.89113158
69MAP3K70.87997327
70PRKCH0.87448469
71TXK0.85760238
72CDK40.85387101
73MELK0.84836002
74PIK3CG0.83606906
75MARK20.81079982
76RET0.77088694
77HCK0.76786389
78CDC42BPA0.75915489
79TNK20.75388438
80MARK30.72896267
81FRK0.72397638
82BMX0.71608003
83LYN0.71380760
84CHEK10.71044411
85RPS6KA40.70324986
86CAMK40.69259474
87ERN10.69059922
88TAOK30.68155751
89FGFR10.67148795
90STK40.67143836
91SGK20.66785687
92TRPM70.65434909
93NTRK20.63658611
94CSK0.62984755
95GRK60.62788200
96LRRK20.62786109
97ATM0.60183841
98ATR0.59117876
99PAK20.56520357
100PRKD20.56051146
101CLK10.55703904
102MAPK70.55640660
103CSNK1A1L0.54802209
104CSNK1D0.54213011
105PDK10.54125996
106FGR0.53475652
107MAPK140.52945111
108JAK20.52922934
109CDK20.52717451
110ERBB20.52705206
111DYRK1A0.52621000
112IKBKB0.52331398
113MAP3K10.51122038
114STK110.50864908
115NEK90.50628979
116DYRK1B0.48768514
117KSR10.47048896
118MAPK80.46535780
119RPS6KB20.45743456
120PTK2B0.45580895
121RPS6KA60.45360938
122MAPK110.44532521
123PRKD10.44079830
124GSK3B0.43547531
125MAPK100.43344077
126IRAK20.42045648
127RPS6KC10.42033953
128ZAP700.41681507
129STK380.41285307
130MAPK10.41070493
131CDK10.40839016
132LCK0.40126333
133PRKDC0.38912973
134SIK30.38793112
135PRKAA10.38309917
136PRKAA20.38219930
137PTK20.37612062
138PIM10.37212723
139SGK10.36837034
140EGFR0.35885698

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.81222354
2B cell receptor signaling pathway_Homo sapiens_hsa046621.72861107
3Lysine degradation_Homo sapiens_hsa003101.69532027
4Adherens junction_Homo sapiens_hsa045201.53801402
5Primary immunodeficiency_Homo sapiens_hsa053401.50746308
6MicroRNAs in cancer_Homo sapiens_hsa052061.48331074
7Pancreatic cancer_Homo sapiens_hsa052121.47930558
8Notch signaling pathway_Homo sapiens_hsa043301.46821243
9Dorso-ventral axis formation_Homo sapiens_hsa043201.44883265
10T cell receptor signaling pathway_Homo sapiens_hsa046601.44648911
11Colorectal cancer_Homo sapiens_hsa052101.43857292
12mTOR signaling pathway_Homo sapiens_hsa041501.43391641
13Endometrial cancer_Homo sapiens_hsa052131.40444512
14Viral myocarditis_Homo sapiens_hsa054161.37485874
15Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37035869
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34617130
17Non-small cell lung cancer_Homo sapiens_hsa052231.32787329
18Osteoclast differentiation_Homo sapiens_hsa043801.32786265
19Small cell lung cancer_Homo sapiens_hsa052221.30441165
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26635517
21Renal cell carcinoma_Homo sapiens_hsa052111.24123833
22Proteoglycans in cancer_Homo sapiens_hsa052051.21864003
23Toxoplasmosis_Homo sapiens_hsa051451.19483251
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.19145947
25Prostate cancer_Homo sapiens_hsa052151.18510153
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.18076289
27Acute myeloid leukemia_Homo sapiens_hsa052211.14990387
28Glioma_Homo sapiens_hsa052141.13311156
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12375605
30Type II diabetes mellitus_Homo sapiens_hsa049301.12255036
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11576520
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.10092988
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09601523
34Focal adhesion_Homo sapiens_hsa045101.09352301
35Circadian rhythm_Homo sapiens_hsa047101.07914038
36Hepatitis B_Homo sapiens_hsa051611.06217019
37Chemokine signaling pathway_Homo sapiens_hsa040621.05869785
38HTLV-I infection_Homo sapiens_hsa051661.05558965
39Thyroid cancer_Homo sapiens_hsa052161.05188930
40Leishmaniasis_Homo sapiens_hsa051401.04403378
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02562533
42Platelet activation_Homo sapiens_hsa046111.02475784
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01232593
44Prolactin signaling pathway_Homo sapiens_hsa049171.00610760
45mRNA surveillance pathway_Homo sapiens_hsa030151.00316660
46Measles_Homo sapiens_hsa051620.99528071
47FoxO signaling pathway_Homo sapiens_hsa040680.99493556
48Long-term potentiation_Homo sapiens_hsa047200.99433535
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97759406
50Basal cell carcinoma_Homo sapiens_hsa052170.96472251
51Herpes simplex infection_Homo sapiens_hsa051680.96307993
52Insulin resistance_Homo sapiens_hsa049310.94739361
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93355769
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92856552
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.92197826
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91141629
57Cholinergic synapse_Homo sapiens_hsa047250.91033571
58Viral carcinogenesis_Homo sapiens_hsa052030.90650407
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90029140
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89437178
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88491674
62Antigen processing and presentation_Homo sapiens_hsa046120.88450983
63ErbB signaling pathway_Homo sapiens_hsa040120.87760201
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87480585
65Pathways in cancer_Homo sapiens_hsa052000.87413276
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87255437
67VEGF signaling pathway_Homo sapiens_hsa043700.87192341
68Hippo signaling pathway_Homo sapiens_hsa043900.86805512
69Estrogen signaling pathway_Homo sapiens_hsa049150.86616528
70Choline metabolism in cancer_Homo sapiens_hsa052310.85770113
71* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85638888
72TNF signaling pathway_Homo sapiens_hsa046680.85289094
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.82584856
74MAPK signaling pathway_Homo sapiens_hsa040100.82434795
75Wnt signaling pathway_Homo sapiens_hsa043100.81689874
76Influenza A_Homo sapiens_hsa051640.81573285
77TGF-beta signaling pathway_Homo sapiens_hsa043500.80700824
78Graft-versus-host disease_Homo sapiens_hsa053320.80502116
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79958116
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78913476
81Phototransduction_Homo sapiens_hsa047440.77441569
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77271682
83Malaria_Homo sapiens_hsa051440.75788275
84Rap1 signaling pathway_Homo sapiens_hsa040150.75173941
85Apoptosis_Homo sapiens_hsa042100.74772655
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74739706
87Hematopoietic cell lineage_Homo sapiens_hsa046400.74465821
88Ras signaling pathway_Homo sapiens_hsa040140.74348207
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.74089763
90Long-term depression_Homo sapiens_hsa047300.73360526
91Dilated cardiomyopathy_Homo sapiens_hsa054140.72895595
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.72425564
93Inositol phosphate metabolism_Homo sapiens_hsa005620.72334447
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.71987632
95Axon guidance_Homo sapiens_hsa043600.70950944
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69744031
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67911469
98Amoebiasis_Homo sapiens_hsa051460.67597821
99ECM-receptor interaction_Homo sapiens_hsa045120.67094590
100Cell cycle_Homo sapiens_hsa041100.65435577
101Endocytosis_Homo sapiens_hsa041440.65017523
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64533747
103Hepatitis C_Homo sapiens_hsa051600.62931798
104Insulin signaling pathway_Homo sapiens_hsa049100.61088054
105Oxytocin signaling pathway_Homo sapiens_hsa049210.60950488
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60543568
107AMPK signaling pathway_Homo sapiens_hsa041520.60156408
108Tuberculosis_Homo sapiens_hsa051520.60150771
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59991639
110cAMP signaling pathway_Homo sapiens_hsa040240.59596502
111Renin secretion_Homo sapiens_hsa049240.58545586
112Autoimmune thyroid disease_Homo sapiens_hsa053200.58394058
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58261392
114GnRH signaling pathway_Homo sapiens_hsa049120.57819992
115HIF-1 signaling pathway_Homo sapiens_hsa040660.57698735
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.55874974
117Melanoma_Homo sapiens_hsa052180.55362352
118Allograft rejection_Homo sapiens_hsa053300.55246226
119Morphine addiction_Homo sapiens_hsa050320.50043952
120Circadian entrainment_Homo sapiens_hsa047130.50015335

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