KAT6B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)4.30211622
2regulation of posttranscriptional gene silencing (GO:0060147)4.14282374
3regulation of gene silencing by miRNA (GO:0060964)4.14282374
4regulation of gene silencing by RNA (GO:0060966)4.14282374
5paraxial mesoderm development (GO:0048339)4.11995167
6lateral sprouting from an epithelium (GO:0060601)4.04428997
7presynaptic membrane assembly (GO:0097105)4.01961411
8pre-miRNA processing (GO:0031054)3.92295258
9central nervous system projection neuron axonogenesis (GO:0021952)3.89600289
10establishment of apical/basal cell polarity (GO:0035089)3.85171559
11nuclear pore complex assembly (GO:0051292)3.81743968
12anterior/posterior axis specification, embryo (GO:0008595)3.80691647
13replication fork processing (GO:0031297)3.72330237
14pyrimidine nucleobase catabolic process (GO:0006208)3.72131923
15presynaptic membrane organization (GO:0097090)3.70394387
16nuclear pore organization (GO:0006999)3.69767148
17somatic hypermutation of immunoglobulin genes (GO:0016446)3.67908646
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.67908646
19histone H3-K9 methylation (GO:0051567)3.65524724
20limb bud formation (GO:0060174)3.58962637
21establishment or maintenance of monopolar cell polarity (GO:0061339)3.56859696
22establishment of monopolar cell polarity (GO:0061162)3.56859696
23cerebral cortex radially oriented cell migration (GO:0021799)3.54724929
24maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.46991776
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45822126
26central nervous system neuron axonogenesis (GO:0021955)3.38773979
27negative regulation of histone methylation (GO:0031061)3.34813235
28histone H4-K5 acetylation (GO:0043981)3.31634055
29histone H4-K8 acetylation (GO:0043982)3.31634055
30neural tube formation (GO:0001841)3.30326624
31regulation of helicase activity (GO:0051095)3.29559265
32histone H3-K9 modification (GO:0061647)3.25849941
33regulation of RNA export from nucleus (GO:0046831)3.18185185
34peptidyl-lysine trimethylation (GO:0018023)3.15564471
35establishment of protein localization to Golgi (GO:0072600)3.13400859
36histone H3-K4 methylation (GO:0051568)3.12819475
37regulation of protein polyubiquitination (GO:1902914)3.12358142
38embryonic process involved in female pregnancy (GO:0060136)3.11920102
39notochord development (GO:0030903)3.10354006
40intestinal epithelial cell development (GO:0060576)3.10094271
41intraciliary transport (GO:0042073)3.09755720
42convergent extension (GO:0060026)3.09641567
43determination of adult lifespan (GO:0008340)3.09560562
44regulation of sister chromatid cohesion (GO:0007063)3.09093944
45axonal fasciculation (GO:0007413)3.08490930
46DNA strand renaturation (GO:0000733)3.07259704
47dosage compensation (GO:0007549)3.06089953
48intracellular estrogen receptor signaling pathway (GO:0030520)3.02563280
49histone H3-K4 trimethylation (GO:0080182)3.01462234
50epithelial cilium movement (GO:0003351)3.00352408
51mitotic sister chromatid cohesion (GO:0007064)3.00004420
52kidney morphogenesis (GO:0060993)2.99680973
53regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.97055732
54regulation of hippo signaling (GO:0035330)2.95367673
55spliceosomal tri-snRNP complex assembly (GO:0000244)2.95159327
56nucleobase catabolic process (GO:0046113)2.94666282
57postsynaptic membrane organization (GO:0001941)2.94636408
58positive regulation of mitotic sister chromatid separation (GO:1901970)2.94590314
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94590314
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94590314
61head development (GO:0060322)2.92307140
62spinal cord development (GO:0021510)2.92199080
63embryonic camera-type eye development (GO:0031076)2.91637137
64mitotic sister chromatid segregation (GO:0000070)2.91126970
65somite development (GO:0061053)2.90009677
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89198847
67startle response (GO:0001964)2.87250074
68embryonic placenta development (GO:0001892)2.87114469
69regulation of translational fidelity (GO:0006450)2.86722639
70protein targeting to Golgi (GO:0000042)2.86198868
71negative regulation of translation, ncRNA-mediated (GO:0040033)2.83011573
72regulation of translation, ncRNA-mediated (GO:0045974)2.83011573
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83011573
74sister chromatid segregation (GO:0000819)2.80267793
75neuron recognition (GO:0008038)2.80244999
76positive regulation of SMAD protein import into nucleus (GO:0060391)2.80089747
77tube closure (GO:0060606)2.79516250
78neural tube closure (GO:0001843)2.79136832
79regulation of histone H3-K9 methylation (GO:0051570)2.79006960
80response to pheromone (GO:0019236)2.78914532
81regulation of telomere maintenance via telomerase (GO:0032210)2.78649374
82histone H4-K16 acetylation (GO:0043984)2.76565525
83negative regulation of cytosolic calcium ion concentration (GO:0051481)2.75750435
84regulation of nuclear cell cycle DNA replication (GO:0033262)2.75733551
85dentate gyrus development (GO:0021542)2.75380182
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73998197
87appendage development (GO:0048736)2.72921586
88limb development (GO:0060173)2.72921586
89negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.72842270
90peptidyl-lysine methylation (GO:0018022)2.70755809
91trophectodermal cell differentiation (GO:0001829)2.70618938
92kinetochore assembly (GO:0051382)2.69672387
93auditory receptor cell differentiation (GO:0042491)2.69136158
94forebrain neuron differentiation (GO:0021879)2.68804686
95neuron cell-cell adhesion (GO:0007158)2.67744115
96regulation of double-strand break repair (GO:2000779)2.67725722
97pore complex assembly (GO:0046931)2.66186970
98dendritic spine morphogenesis (GO:0060997)2.65758573
99cornea development in camera-type eye (GO:0061303)2.64376143
100histone H2A monoubiquitination (GO:0035518)2.63337289
101cilium movement (GO:0003341)2.63321481
102retinal ganglion cell axon guidance (GO:0031290)2.62023408
103behavioral response to nicotine (GO:0035095)2.61558014
104regulation of gene silencing (GO:0060968)2.61337839
105regulation of hexokinase activity (GO:1903299)2.60181076
106regulation of glucokinase activity (GO:0033131)2.60181076
107sympathetic nervous system development (GO:0048485)2.60008179
108heterochromatin organization (GO:0070828)2.58486954
109polarized epithelial cell differentiation (GO:0030859)2.58053971
110regulation of integrin activation (GO:0033623)2.56665460
111DNA demethylation (GO:0080111)2.56167663
112protein K6-linked ubiquitination (GO:0085020)2.56072095
113histone lysine demethylation (GO:0070076)2.55387396
114regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54921993
115microtubule anchoring (GO:0034453)2.54712415
116kinetochore organization (GO:0051383)2.54690831
117DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.54664656
118regulation of gene expression by genetic imprinting (GO:0006349)2.54490399
119L-fucose catabolic process (GO:0042355)2.54130455
120fucose catabolic process (GO:0019317)2.54130455
121L-fucose metabolic process (GO:0042354)2.54130455
122cell migration in hindbrain (GO:0021535)2.53368826
123histone methylation (GO:0016571)2.51798581
124synapse assembly (GO:0007416)2.50825684
125olfactory bulb development (GO:0021772)2.50460997
126positive regulation of chromosome segregation (GO:0051984)2.50273325
127pituitary gland development (GO:0021983)2.50079459
128regulation of DNA methylation (GO:0044030)2.49820666
129cilium organization (GO:0044782)2.49548213
130negative regulation of chromatin modification (GO:1903309)2.49463614
131cell proliferation in forebrain (GO:0021846)2.49395817
132negative regulation of androgen receptor signaling pathway (GO:0060766)2.49195182
133NLS-bearing protein import into nucleus (GO:0006607)2.48538600
134establishment of nucleus localization (GO:0040023)2.47654308
135protein localization to Golgi apparatus (GO:0034067)2.47088306
136meiotic chromosome segregation (GO:0045132)2.47070574
137axoneme assembly (GO:0035082)2.46650242
138hindbrain development (GO:0030902)2.46178925
139histone demethylation (GO:0016577)2.46042306
140negative regulation of dendrite development (GO:2000171)2.45563913
141cilium assembly (GO:0042384)2.45334264
142mitotic metaphase plate congression (GO:0007080)2.45121769
143nonmotile primary cilium assembly (GO:0035058)2.44673195
144cilium morphogenesis (GO:0060271)2.44643434
145cilium or flagellum-dependent cell motility (GO:0001539)2.44618235
146interkinetic nuclear migration (GO:0022027)2.43311006
147histone lysine methylation (GO:0034968)2.42832100
148nucleus localization (GO:0051647)2.42339952
149protein localization to cilium (GO:0061512)2.42308236
150regulation of timing of cell differentiation (GO:0048505)2.42289196
151regulation of nucleobase-containing compound transport (GO:0032239)2.41589682
152regulation of DNA damage checkpoint (GO:2000001)2.41367389
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40893252
154brain morphogenesis (GO:0048854)2.40636604
155transmission of nerve impulse (GO:0019226)2.40173250
156seminiferous tubule development (GO:0072520)2.40013487
157anatomical structure regression (GO:0060033)2.39835598
158monoubiquitinated protein deubiquitination (GO:0035520)2.39367410
159regulation of male gonad development (GO:2000018)2.39080574
160histone arginine methylation (GO:0034969)2.39004381
161DNA geometric change (GO:0032392)2.38901915
162mRNA splice site selection (GO:0006376)2.38768850
163DNA replication-dependent nucleosome assembly (GO:0006335)2.38295669
164DNA replication-dependent nucleosome organization (GO:0034723)2.38295669
165negative regulation of histone modification (GO:0031057)2.38195211
166negative regulation of DNA repair (GO:0045738)2.38029676
167regulation of telomere maintenance (GO:0032204)2.37661778
168protein localization to kinetochore (GO:0034501)2.36705692
169chromatin assembly (GO:0031497)2.36401890
170photoreceptor cell maintenance (GO:0045494)2.36051894
171regulation of DNA endoreduplication (GO:0032875)2.35647059
172positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.35498251
173regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.35498251
174cytoplasmic mRNA processing body assembly (GO:0033962)2.34721034
175mechanosensory behavior (GO:0007638)2.34705953
176ionotropic glutamate receptor signaling pathway (GO:0035235)2.34583792
177cerebral cortex cell migration (GO:0021795)2.34420885
178retinal cone cell development (GO:0046549)2.34262845
179otic vesicle formation (GO:0030916)2.33648899
180inner ear receptor stereocilium organization (GO:0060122)2.33298151
181spinal cord motor neuron differentiation (GO:0021522)2.30468692
182positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.30301956
183regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.30301956
184regulation of cilium movement (GO:0003352)2.28992725
185DNA double-strand break processing (GO:0000729)2.28822997
186acrosome reaction (GO:0007340)2.28812133
187protein K11-linked deubiquitination (GO:0035871)2.26557586
188glutamate receptor signaling pathway (GO:0007215)2.25761020
189regulation of development, heterochronic (GO:0040034)2.24694684
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.24100001
191cranial nerve morphogenesis (GO:0021602)2.22140320
192ventricular system development (GO:0021591)2.21498563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.53188701
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.43032267
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.43032267
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.43032267
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.25977557
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse4.07167086
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.58433362
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.29577405
9SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.98303632
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.94825106
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.88480478
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.86595706
13ZNF274_21170338_ChIP-Seq_K562_Hela2.79059145
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67561411
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.64546889
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.63636401
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.60587935
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.59518860
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59095686
20IGF1R_20145208_ChIP-Seq_DFB_Human2.55030048
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50458924
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46487380
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44283097
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.41970753
25VDR_22108803_ChIP-Seq_LS180_Human2.37959348
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.35180709
27TAF15_26573619_Chip-Seq_HEK293_Human2.32377918
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24222771
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19895853
30TCF3_18692474_ChIP-Seq_MEFs_Mouse2.16630408
31NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.14955128
32POU5F1_16518401_ChIP-PET_MESCs_Mouse2.11620396
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04597575
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.04217993
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03664256
36SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03423890
37CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03126565
38P300_19829295_ChIP-Seq_ESCs_Human2.02554997
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.99293075
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94099184
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89956365
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89534938
43AR_21572438_ChIP-Seq_LNCaP_Human1.87959372
44SMAD4_21799915_ChIP-Seq_A2780_Human1.87191980
45EWS_26573619_Chip-Seq_HEK293_Human1.85731871
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.81517550
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80395383
48TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.77561260
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.74321959
50POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.74300855
51ER_23166858_ChIP-Seq_MCF-7_Human1.73865519
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.72473234
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72150225
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70681449
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.67830692
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65129051
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63686326
58PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.60490096
59TBX3_20139965_ChIP-Seq_ESCs_Mouse1.60448340
60AR_25329375_ChIP-Seq_VCAP_Human1.58830443
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.58675169
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.58381862
63NANOG_18692474_ChIP-Seq_MESCs_Mouse1.56325184
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56266424
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55734792
66TCF4_23295773_ChIP-Seq_U87_Human1.54228159
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52772687
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52434504
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52061667
70CBP_20019798_ChIP-Seq_JUKART_Human1.52061667
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.50827173
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46899098
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46546374
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45809527
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45805560
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45692276
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45422094
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44926511
79SOX2_18692474_ChIP-Seq_MESCs_Mouse1.44769085
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44434213
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.42100641
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42052241
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41737723
84REST_21632747_ChIP-Seq_MESCs_Mouse1.39528852
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39157991
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.38634281
87BCAT_22108803_ChIP-Seq_LS180_Human1.36927982
88NANOG_16518401_ChIP-PET_MESCs_Mouse1.36351750
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36022654
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.34705487
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34036626
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33441812
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.31282974
94JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31146336
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29791829
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28939344
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27583257
98RUNX2_22187159_ChIP-Seq_PCA_Human1.24988199
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24896090
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.24535588
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23047670
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20829264
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19896481
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.19745803
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19263916
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17451356
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17156890
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16919304
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16599253
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15987295
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.14853605
112TCF4_22108803_ChIP-Seq_LS180_Human1.14519281
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.14072328
114DROSHA_22980978_ChIP-Seq_HELA_Human1.11705545
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11209247
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10987700
117POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10825289
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.10823726
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09445400
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09425916
121RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08934389
122PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08782877
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08733070
124KAP1_27257070_Chip-Seq_ESCs_Mouse1.08118205
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07893920
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.07816086
127P53_22387025_ChIP-Seq_ESCs_Mouse1.07539285
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07456594
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.07126272
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07075080
131EZH2_22144423_ChIP-Seq_EOC_Human1.06728914
132E2F1_18555785_Chip-Seq_ESCs_Mouse1.06387181
133MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06246797
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06002885
135GATA1_26923725_Chip-Seq_HPCs_Mouse1.05638506
136NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05301536
137CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04914197
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04396544
139ISL1_27105846_Chip-Seq_CPCs_Mouse1.04041835
140KDM2B_26808549_Chip-Seq_REH_Human1.02974645
141STAT3_18555785_ChIP-Seq_MESCs_Mouse1.02311585
142SOX2_16153702_ChIP-ChIP_HESCs_Human1.01347873
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01187133
144NFE2_27457419_Chip-Seq_LIVER_Mouse0.99634302
145SOX9_26525672_Chip-Seq_HEART_Mouse0.99208130
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98176183
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.97762317
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97212289
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96830822
150MYC_18555785_ChIP-Seq_MESCs_Mouse0.96809952
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.96339889
152SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96337706
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96169256
154KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96075472
155YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94214062
156FUS_26573619_Chip-Seq_HEK293_Human0.93917932
157PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92465444
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91870147
159SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90900704
160MYCN_18555785_ChIP-Seq_MESCs_Mouse0.87200387
161MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85494560
162EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85138281
163WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82621712
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.82603350
165TP53_16413492_ChIP-PET_HCT116_Human0.81755299
166STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79800386
167KDM2B_26808549_Chip-Seq_K562_Human0.75442658
168GBX2_23144817_ChIP-Seq_PC3_Human0.74744379
169AHR_22903824_ChIP-Seq_MCF-7_Human0.74404371
170EGR1_19374776_ChIP-ChIP_THP-1_Human0.74194463
171RARB_27405468_Chip-Seq_BRAIN_Mouse0.74042290
172RNF2_27304074_Chip-Seq_NSC_Mouse0.73955190
173IRF1_19129219_ChIP-ChIP_H3396_Human0.71716253
174STAT3_23295773_ChIP-Seq_U87_Human0.67770004
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.67530492
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.67530492
177AR_19668381_ChIP-Seq_PC3_Human0.67359803
178CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.67324825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.52866867
2MP0010030_abnormal_orbit_morphology2.53793424
3MP0002653_abnormal_ependyma_morphology2.46091432
4MP0003787_abnormal_imprinting2.34853243
5MP0003890_abnormal_embryonic-extraembry2.31711693
6MP0006292_abnormal_olfactory_placode2.28681069
7MP0004133_heterotaxia2.23598300
8MP0010094_abnormal_chromosome_stability2.22444963
9MP0003111_abnormal_nucleus_morphology2.15827306
10MP0001293_anophthalmia2.13526786
11MP0003283_abnormal_digestive_organ2.03032049
12MP0003121_genomic_imprinting1.97126978
13MP0003880_abnormal_central_pattern1.92855287
14MP0005076_abnormal_cell_differentiation1.92720562
15MP0000566_synostosis1.89134601
16MP0003119_abnormal_digestive_system1.87106816
17MP0001984_abnormal_olfaction1.86453676
18MP0002084_abnormal_developmental_patter1.82804466
19MP0008058_abnormal_DNA_repair1.78304941
20MP0002249_abnormal_larynx_morphology1.75998862
21MP0001486_abnormal_startle_reflex1.74658767
22MP0002085_abnormal_embryonic_tissue1.73491169
23MP0002234_abnormal_pharynx_morphology1.72628222
24MP0009046_muscle_twitch1.72472390
25MP0008877_abnormal_DNA_methylation1.71418980
26MP0005646_abnormal_pituitary_gland1.70436171
27MP0003941_abnormal_skin_development1.68432383
28MP0004957_abnormal_blastocyst_morpholog1.63010645
29MP0003136_yellow_coat_color1.62343836
30MP0003635_abnormal_synaptic_transmissio1.59980160
31MP0005645_abnormal_hypothalamus_physiol1.57462044
32MP0009745_abnormal_behavioral_response1.56746536
33MP0002184_abnormal_innervation1.56653646
34MP0006276_abnormal_autonomic_nervous1.56543550
35MP0002272_abnormal_nervous_system1.55768727
36MP0001968_abnormal_touch/_nociception1.55278194
37MP0001485_abnormal_pinna_reflex1.55124695
38MP0003755_abnormal_palate_morphology1.54840776
39MP0005248_abnormal_Harderian_gland1.54343124
40MP0004197_abnormal_fetal_growth/weight/1.54068111
41MP0001188_hyperpigmentation1.53624603
42MP0003077_abnormal_cell_cycle1.53572930
43MP0004264_abnormal_extraembryonic_tissu1.52457102
44MP0000516_abnormal_urinary_system1.51789826
45MP0005367_renal/urinary_system_phenotyp1.51789826
46MP0002735_abnormal_chemical_nociception1.51026508
47MP0006072_abnormal_retinal_apoptosis1.48730520
48MP0005551_abnormal_eye_electrophysiolog1.47921519
49MP0002751_abnormal_autonomic_nervous1.45685558
50MP0004233_abnormal_muscle_weight1.45380674
51MP0003937_abnormal_limbs/digits/tail_de1.44708382
52MP0005380_embryogenesis_phenotype1.43733828
53MP0001672_abnormal_embryogenesis/_devel1.43733828
54MP0002572_abnormal_emotion/affect_behav1.43695367
55MP0003935_abnormal_craniofacial_develop1.43469460
56MP0004043_abnormal_pH_regulation1.43302301
57MP0002063_abnormal_learning/memory/cond1.43191837
58MP0002557_abnormal_social/conspecific_i1.42375038
59MP0000778_abnormal_nervous_system1.39567990
60MP0003861_abnormal_nervous_system1.39172257
61MP0003123_paternal_imprinting1.36969977
62MP0000350_abnormal_cell_proliferation1.36804078
63MP0002638_abnormal_pupillary_reflex1.35320128
64MP0004270_analgesia1.34938905
65MP0003693_abnormal_embryo_hatching1.34412287
66MP0005253_abnormal_eye_physiology1.33822064
67MP0002086_abnormal_extraembryonic_tissu1.33720509
68MP0010352_gastrointestinal_tract_polyps1.33010968
69MP0000432_abnormal_head_morphology1.30162994
70MP0000428_abnormal_craniofacial_morphol1.29119855
71MP0001502_abnormal_circadian_rhythm1.28959110
72MP0004142_abnormal_muscle_tone1.28499743
73MP0001697_abnormal_embryo_size1.26089762
74MP0002116_abnormal_craniofacial_bone1.24954656
75MP0005394_taste/olfaction_phenotype1.24784784
76MP0005499_abnormal_olfactory_system1.24784784
77MP0010307_abnormal_tumor_latency1.21972511
78MP0005423_abnormal_somatic_nervous1.21477037
79MP0001529_abnormal_vocalization1.20855066
80MP0002736_abnormal_nociception_after1.19580885
81MP0000955_abnormal_spinal_cord1.19196992
82MP0002067_abnormal_sensory_capabilities1.18747013
83MP0004742_abnormal_vestibular_system1.18533937
84MP0005386_behavior/neurological_phenoty1.18469834
85MP0004924_abnormal_behavior1.18469834
86MP0002088_abnormal_embryonic_growth/wei1.17727474
87MP0003984_embryonic_growth_retardation1.17579679
88MP0002064_seizures1.16851666
89MP0002938_white_spotting1.16683049
90MP0009703_decreased_birth_body1.16353595
91MP0002734_abnormal_mechanical_nocicepti1.14291656
92MP0003385_abnormal_body_wall1.14108029
93MP0002009_preneoplasia1.14033645
94MP0005171_absent_coat_pigmentation1.13880605
95MP0002882_abnormal_neuron_morphology1.11319817
96MP0001286_abnormal_eye_development1.10929446
97MP0000537_abnormal_urethra_morphology1.10654047
98MP0002102_abnormal_ear_morphology1.10542723
99MP0001730_embryonic_growth_arrest1.10248491
100MP0000049_abnormal_middle_ear1.10170380
101MP0000613_abnormal_salivary_gland1.09339793
102MP0001501_abnormal_sleep_pattern1.08919178
103MP0002752_abnormal_somatic_nervous1.07508448
104MP0002114_abnormal_axial_skeleton1.06891965
105MP0003786_premature_aging1.06793339
106MP0000427_abnormal_hair_cycle1.05557230
107MP0003567_abnormal_fetal_cardiomyocyte1.04872381
108MP0002092_abnormal_eye_morphology1.04365625
109MP0005623_abnormal_meninges_morphology1.04359056
110MP0002909_abnormal_adrenal_gland1.04023477
111MP0002697_abnormal_eye_size1.03069091
112MP0003122_maternal_imprinting1.02878488
113MP0004145_abnormal_muscle_electrophysio1.01712628
114MP0008789_abnormal_olfactory_epithelium1.01621649
115MP0010386_abnormal_urinary_bladder0.99991811
116MP0008995_early_reproductive_senescence0.99740740
117MP0002111_abnormal_tail_morphology0.99371030
118MP0000026_abnormal_inner_ear0.99084721
119MP0008961_abnormal_basal_metabolism0.99049540
120MP0002932_abnormal_joint_morphology0.98725574
121MP0000569_abnormal_digit_pigmentation0.98613468
122MP0002233_abnormal_nose_morphology0.98315171
123MP0003705_abnormal_hypodermis_morpholog0.97141483
124MP0000762_abnormal_tongue_morphology0.96789693
125MP0008872_abnormal_physiological_respon0.94834564
126MP0009053_abnormal_anal_canal0.94796278
127MP0001177_atelectasis0.94777789
128MP0003698_abnormal_male_reproductive0.94715824
129MP0008932_abnormal_embryonic_tissue0.94400419
130MP0002822_catalepsy0.94246476
131MP0005187_abnormal_penis_morphology0.92914348
132MP0000579_abnormal_nail_morphology0.92629849
133MP0004885_abnormal_endolymph0.92431102
134MP0005391_vision/eye_phenotype0.92086924
135MP0004859_abnormal_synaptic_plasticity0.91401098
136MP0000631_abnormal_neuroendocrine_gland0.90919544
137MP0001970_abnormal_pain_threshold0.90840521
138MP0000462_abnormal_digestive_system0.90334035
139MP0003938_abnormal_ear_development0.89488055
140MP0002733_abnormal_thermal_nociception0.88909053
141MP0004134_abnormal_chest_morphology0.88673874
142MP0001270_distended_abdomen0.88630825
143MP0004811_abnormal_neuron_physiology0.88044086
144MP0002080_prenatal_lethality0.87310856
145MP0002152_abnormal_brain_morphology0.86908489
146MP0002928_abnormal_bile_duct0.86536522
147MP0002210_abnormal_sex_determination0.86364874
148MP0003942_abnormal_urinary_system0.86235634
149MP0002282_abnormal_trachea_morphology0.85248954
150MP0004085_abnormal_heartbeat0.84251519
151MP0002925_abnormal_cardiovascular_devel0.84093279
152MP0001944_abnormal_pancreas_morphology0.83318285
153MP0002837_dystrophic_cardiac_calcinosis0.83039304
154MP0002081_perinatal_lethality0.82727491
155MP0003936_abnormal_reproductive_system0.82524136
156MP0000383_abnormal_hair_follicle0.81272693
157MP0003115_abnormal_respiratory_system0.80462526
158MP0001849_ear_inflammation0.80440469
159MP0001145_abnormal_male_reproductive0.79973415
160MP0002075_abnormal_coat/hair_pigmentati0.79263861
161MP0001346_abnormal_lacrimal_gland0.79217848
162MP0008007_abnormal_cellular_replicative0.77796616

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)3.90115589
2Rib fusion (HP:0000902)3.74102897
3Chronic hepatic failure (HP:0100626)3.50009899
4Ependymoma (HP:0002888)3.45787380
5Nephronophthisis (HP:0000090)3.32742949
6Genetic anticipation (HP:0003743)3.32418654
7Astrocytoma (HP:0009592)3.27655829
8Abnormality of the astrocytes (HP:0100707)3.27655829
9Intestinal fistula (HP:0100819)3.17790372
10Facial hemangioma (HP:0000329)3.15447831
11Abnormality of midbrain morphology (HP:0002418)3.10284944
12Molar tooth sign on MRI (HP:0002419)3.10284944
13Glioma (HP:0009733)3.05833984
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.04659042
15Short 4th metacarpal (HP:0010044)3.04659042
16Rectovaginal fistula (HP:0000143)3.02086206
17Rectal fistula (HP:0100590)3.02086206
18Medulloblastoma (HP:0002885)3.00684214
19Pancreatic cysts (HP:0001737)2.98266148
20Pancreatic fibrosis (HP:0100732)2.96811403
21Volvulus (HP:0002580)2.95330530
22Abnormality of the renal medulla (HP:0100957)2.91910046
23Broad-based gait (HP:0002136)2.91814635
24Progressive cerebellar ataxia (HP:0002073)2.89049642
25True hermaphroditism (HP:0010459)2.86649650
26Absent radius (HP:0003974)2.85721758
27Protruding tongue (HP:0010808)2.85090131
28Drooling (HP:0002307)2.81901904
29Febrile seizures (HP:0002373)2.81853149
30Supernumerary ribs (HP:0005815)2.81600921
31* Abnormality of the labia minora (HP:0012880)2.80540799
32Aplasia involving forearm bones (HP:0009822)2.72943935
33Absent forearm bone (HP:0003953)2.72943935
34Abnormality of the renal cortex (HP:0011035)2.67726983
35Shawl scrotum (HP:0000049)2.65459097
36Anal stenosis (HP:0002025)2.65450269
37Abnormal number of incisors (HP:0011064)2.64970019
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61283822
39Supernumerary bones of the axial skeleton (HP:0009144)2.59154797
40Hepatoblastoma (HP:0002884)2.57764249
41Gaze-evoked nystagmus (HP:0000640)2.56771502
42Widely spaced teeth (HP:0000687)2.55215526
43* Neoplasm of the oral cavity (HP:0100649)2.55014362
44Excessive salivation (HP:0003781)2.53800718
45Chromsome breakage (HP:0040012)2.52470843
46Anophthalmia (HP:0000528)2.48328172
47Midline defect of the nose (HP:0004122)2.45146049
48Supernumerary spleens (HP:0009799)2.44685606
49Trigonocephaly (HP:0000243)2.44585808
50Tubulointerstitial nephritis (HP:0001970)2.44150377
51Short humerus (HP:0005792)2.44035376
52Neoplasm of striated muscle (HP:0009728)2.42591230
53Vaginal fistula (HP:0004320)2.41549966
54Neoplasm of the adrenal cortex (HP:0100641)2.36598590
55Aplasia/hypoplasia of the humerus (HP:0006507)2.36059870
56Abnormal hair whorl (HP:0010721)2.34907478
57Truncal obesity (HP:0001956)2.33326558
58Alacrima (HP:0000522)2.33067120
59Medial flaring of the eyebrow (HP:0010747)2.29699448
60Absent speech (HP:0001344)2.28754265
61Focal seizures (HP:0007359)2.27570749
62Abnormality of the diencephalon (HP:0010662)2.26435928
63Epileptic encephalopathy (HP:0200134)2.25910347
64Abnormality of the nasal septum (HP:0000419)2.24488163
65Tented upper lip vermilion (HP:0010804)2.23508188
66Hemivertebrae (HP:0002937)2.21689925
67Esophageal atresia (HP:0002032)2.21662182
68Attenuation of retinal blood vessels (HP:0007843)2.21654380
69Abnormality of the 4th metacarpal (HP:0010012)2.21198361
70Focal motor seizures (HP:0011153)2.20567496
71Congenital stationary night blindness (HP:0007642)2.20505238
72Rhabdomyosarcoma (HP:0002859)2.20009211
73Cystic liver disease (HP:0006706)2.15416637
74Broad thumb (HP:0011304)2.11051026
75Urethral obstruction (HP:0000796)2.10850991
76Short phalanx of the thumb (HP:0009660)2.10045522
77Abnormality of the lower motor neuron (HP:0002366)2.09761301
78Gastrointestinal atresia (HP:0002589)2.06052115
79Concave nail (HP:0001598)2.05455424
80Lissencephaly (HP:0001339)2.05020148
81Intestinal atresia (HP:0011100)2.04216603
82Abnormal drinking behavior (HP:0030082)2.03551857
83Polydipsia (HP:0001959)2.03551857
84Hypochromic microcytic anemia (HP:0004840)2.03161842
85Oligodactyly (HP:0012165)2.02371067
86Decreased lacrimation (HP:0000633)2.01034306
87Optic nerve hypoplasia (HP:0000609)1.99758758
88Thyroid-stimulating hormone excess (HP:0002925)1.99614995
89Sparse lateral eyebrow (HP:0005338)1.99560584
90Tubular atrophy (HP:0000092)1.99174563
91Aqueductal stenosis (HP:0002410)1.99045803
92Depressed nasal tip (HP:0000437)1.98735871
93Narrow forehead (HP:0000341)1.98252739
94Genital tract atresia (HP:0001827)1.97873509
95Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.97399974
96Gait imbalance (HP:0002141)1.96654242
97Renal cortical cysts (HP:0000803)1.96444802
98Inability to walk (HP:0002540)1.95801950
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.95790136
100Short 1st metacarpal (HP:0010034)1.95565118
101Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.95565118
102Selective tooth agenesis (HP:0001592)1.94825362
103Anteriorly placed anus (HP:0001545)1.94007575
104Abdominal situs inversus (HP:0003363)1.92968375
105Abnormality of abdominal situs (HP:0011620)1.92968375
106Dialeptic seizures (HP:0011146)1.92341669
107Hypoplastic labia majora (HP:0000059)1.92318642
108Vertebral fusion (HP:0002948)1.91059875
109Postaxial hand polydactyly (HP:0001162)1.90509337
110Abnormality of the parietal bone (HP:0002696)1.90192537
111Pachygyria (HP:0001302)1.90110277
112Ectopic kidney (HP:0000086)1.90016588
113Renal hypoplasia (HP:0000089)1.87995589
114Fair hair (HP:0002286)1.87607192
115Atonic seizures (HP:0010819)1.87457111
116Highly arched eyebrow (HP:0002553)1.86704739
117Colon cancer (HP:0003003)1.86666882
118Preaxial foot polydactyly (HP:0001841)1.86540888
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.85007585
120Epileptiform EEG discharges (HP:0011182)1.84454866
121EEG with generalized epileptiform discharges (HP:0011198)1.84173519
122Abnormality of the ileum (HP:0001549)1.83346401
123Papillary thyroid carcinoma (HP:0002895)1.82698486
124Impulsivity (HP:0100710)1.82610770
125Abnormality of the incisor (HP:0000676)1.82531693
126Hypoplastic iliac wings (HP:0002866)1.81811418
127Vaginal atresia (HP:0000148)1.81354254
128Shallow orbits (HP:0000586)1.80851599
129Skull defect (HP:0001362)1.80617835
130Agitation (HP:0000713)1.80531760
131Congenital primary aphakia (HP:0007707)1.80417808
132Megalencephaly (HP:0001355)1.80044928
133Long eyelashes (HP:0000527)1.79468358
134Type II lissencephaly (HP:0007260)1.79390757
135Abnormality of the metopic suture (HP:0005556)1.79288444
136Hypotelorism (HP:0000601)1.79277311
137Hypsarrhythmia (HP:0002521)1.79078897
138Lip pit (HP:0100267)1.78971622
139Nephroblastoma (Wilms tumor) (HP:0002667)1.78521288
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.77746173
141Oligodactyly (hands) (HP:0001180)1.77039385
142Intellectual disability, severe (HP:0010864)1.76911871
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.76790760
144Acute lymphatic leukemia (HP:0006721)1.75119780
145Turricephaly (HP:0000262)1.74906204
146Abnormality of macular pigmentation (HP:0008002)1.74895403
147Bilateral microphthalmos (HP:0007633)1.74432211
148Absence seizures (HP:0002121)1.73781701
149Nephrogenic diabetes insipidus (HP:0009806)1.73771903
150Abnormality of the labia majora (HP:0012881)1.73732612
151Abnormality of the salivary glands (HP:0010286)1.73465647
152Hypoplasia of the maxilla (HP:0000327)1.72695937
153* Patellar aplasia (HP:0006443)1.71054924
154Stomach cancer (HP:0012126)1.71021751
155Anal atresia (HP:0002023)1.70871146
156Abnormality of the parathyroid morphology (HP:0011766)1.70666554
157Broad phalanges of the hand (HP:0009768)1.69818626
158Hamartoma (HP:0010566)1.69085735
159Progressive inability to walk (HP:0002505)1.68552987
160Bulbous nose (HP:0000414)1.68431573
161Small hand (HP:0200055)1.68382355
162Dynein arm defect of respiratory motile cilia (HP:0012255)1.67992690
163Absent/shortened dynein arms (HP:0200106)1.67992690
164Basal cell carcinoma (HP:0002671)1.67382423
165Short thumb (HP:0009778)1.66296340
166Increased number of teeth (HP:0011069)1.66049067
167Abnormality of the phalanges of the hallux (HP:0010057)1.65751155
168Short foot (HP:0001773)1.65731122
169Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65559885
170Postaxial foot polydactyly (HP:0001830)1.65369098
171Embryonal renal neoplasm (HP:0011794)1.65334612
172Poor coordination (HP:0002370)1.64992824
173Abnormality of the aortic arch (HP:0012303)1.64804552
174Ectopic anus (HP:0004397)1.63773809
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63398634
176* Prominent nasal bridge (HP:0000426)1.63324252
177Abnormal rod and cone electroretinograms (HP:0008323)1.63212557
178Coronal craniosynostosis (HP:0004440)1.63202374
179Large earlobe (HP:0009748)1.63042148
180Hemiparesis (HP:0001269)1.62936625
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.62734993
182Exotropia (HP:0000577)1.62688998
183Gastrointestinal carcinoma (HP:0002672)1.62542340
184Malignant gastrointestinal tract tumors (HP:0006749)1.62542340
185Cutaneous finger syndactyly (HP:0010554)1.61888047
186Meckel diverticulum (HP:0002245)1.61678700
187Congenital hepatic fibrosis (HP:0002612)1.61291523
188* Micropenis (HP:0000054)1.61123198
189Gastroesophageal reflux (HP:0002020)1.61104186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.52839562
2FRK5.02510262
3CASK3.48753785
4BRD43.24920475
5AKT33.12490298
6LATS13.08236277
7ICK3.06229804
8DDR22.64010552
9EPHA22.53628406
10TNIK2.46984326
11LATS22.17408981
12MAPK132.15405518
13MAP3K62.14775782
14BMPR1B2.13000497
15TYRO32.09626599
16MAP4K22.09238596
17PNCK1.90623885
18TTK1.88573850
19CHEK21.87664446
20NUAK11.85704912
21CDC71.72276753
22CDK71.67360225
23PRPF4B1.60323982
24TAOK31.59476580
25EPHA31.57783165
26MAPK151.48839329
27TRIM281.47012070
28STK38L1.43598505
29CAMK1D1.35834212
30MKNK21.34898439
31SRPK11.32000890
32WNK41.29004348
33SGK4941.27704690
34SGK2231.27704690
35PLK11.27457602
36PDGFRA1.26249903
37NEK21.26142447
38PRKD21.25059544
39PAK31.24343016
40EPHA41.23452639
41CAMK1G1.22845674
42STK391.22763325
43MAP2K71.19614650
44MTOR1.17730233
45BCR1.14397534
46YES11.14237520
47ATR1.14159522
48CHEK11.12887677
49STK381.09501097
50KSR11.08867274
51NTRK21.05555419
52ATM1.04407999
53MAP3K91.03497229
54NTRK31.02657943
55SIK21.00157866
56GRK10.97842592
57WEE10.96710764
58CDK20.93867274
59CDC42BPA0.93620633
60MAP3K40.91286985
61NLK0.90441635
62FGR0.87504740
63STK30.86600191
64UHMK10.86165049
65ADRBK20.86058473
66CSNK1G20.85454038
67WNK10.84634323
68BMX0.84081986
69PIK3CA0.83953844
70BRSK20.83651251
71CDK60.80276087
72DAPK10.79845078
73FGFR20.78695446
74MAPK100.78563788
75ERBB30.77730684
76ALK0.77659153
77CDK10.77531752
78PLK30.77414718
79PINK10.75984137
80DYRK20.74745780
81PKN10.73321838
82PRKCG0.73055672
83DYRK30.72812470
84PAK60.72699321
85PRKD30.72187079
86MAPK140.71159263
87OBSCN0.71119703
88ACVR1B0.70806825
89GSK3B0.69576460
90CSNK1D0.69554328
91MARK20.68513041
92RPS6KB20.68509261
93DMPK0.67927963
94INSRR0.67911085
95MARK10.67117274
96CSNK1E0.65873629
97MKNK10.65383573
98MATK0.65275706
99NEK90.64775681
100NEK10.64447500
101CDK90.64357373
102CSNK1G10.64215835
103EPHB20.64168913
104HIPK20.63806124
105CDK40.62963676
106CAMK40.62794997
107PRKAA10.62461742
108PRKCE0.62442620
109PRKCI0.61901761
110CSNK1A1L0.59672241
111TNK20.59528734
112SGK20.59339034
113SGK30.57946548
114DYRK1A0.57233682
115PRKDC0.56577323
116MAPK10.55496507
117FGFR10.54805340
118CHUK0.54249126
119STK110.52407295
120CAMK10.51589140
121AURKB0.50507629
122CSNK1G30.50065787
123SGK10.49931725
124AKT10.48267711
125IRAK10.47480033
126KIT0.47337687
127CDK30.46914945
128MAP3K70.46879920
129AKT20.46612482
130PRKCZ0.46543232
131OXSR10.46383835
132PLK40.45830548
133MAPK80.44534542
134PRKG10.44020094
135PDGFRB0.43222933
136PTK2B0.43010119
137PHKG10.42919321
138PHKG20.42919321
139CDK50.42670839
140ERBB40.42359165
141FGFR30.42163646
142RPS6KA30.41706799
143MELK0.41431156
144GSK3A0.41317463
145WNK30.40686430
146MINK10.39523653
147PRKCH0.39090127
148PASK0.38678728
149SIK30.38472423
150NEK60.38076320
151VRK10.37457000
152PIM10.36978087
153CAMK2A0.36868743
154PRKAA20.36664156
155MARK30.36445135
156CCNB10.36409537
157CDK80.35703360
158STK40.35327988

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.85242198
2Basal cell carcinoma_Homo sapiens_hsa052172.51654971
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38929778
4mRNA surveillance pathway_Homo sapiens_hsa030152.33748798
5Hedgehog signaling pathway_Homo sapiens_hsa043402.26050496
6Fanconi anemia pathway_Homo sapiens_hsa034602.21640396
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.18403762
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.11351942
9RNA transport_Homo sapiens_hsa030132.06605489
10Hippo signaling pathway_Homo sapiens_hsa043901.97821544
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93146300
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91299120
13Notch signaling pathway_Homo sapiens_hsa043301.90806468
14Cell cycle_Homo sapiens_hsa041101.88127532
15Butanoate metabolism_Homo sapiens_hsa006501.85079250
16Spliceosome_Homo sapiens_hsa030401.72544866
17Adherens junction_Homo sapiens_hsa045201.70610056
18Wnt signaling pathway_Homo sapiens_hsa043101.70371514
19mTOR signaling pathway_Homo sapiens_hsa041501.68346695
20Base excision repair_Homo sapiens_hsa034101.60166674
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59246290
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.58294642
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55886391
24DNA replication_Homo sapiens_hsa030301.55349626
25Homologous recombination_Homo sapiens_hsa034401.54726527
26MicroRNAs in cancer_Homo sapiens_hsa052061.50611386
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49759793
28TGF-beta signaling pathway_Homo sapiens_hsa043501.48980738
29Nicotine addiction_Homo sapiens_hsa050331.47988660
30Lysine degradation_Homo sapiens_hsa003101.46601044
31Oocyte meiosis_Homo sapiens_hsa041141.42131912
32Phototransduction_Homo sapiens_hsa047441.41061393
33Cocaine addiction_Homo sapiens_hsa050301.37866743
34Basal transcription factors_Homo sapiens_hsa030221.35348467
35Salivary secretion_Homo sapiens_hsa049701.33509865
36Fatty acid biosynthesis_Homo sapiens_hsa000611.30403440
37Linoleic acid metabolism_Homo sapiens_hsa005911.29737402
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29228717
39Propanoate metabolism_Homo sapiens_hsa006401.28881562
40Dorso-ventral axis formation_Homo sapiens_hsa043201.27858287
41Colorectal cancer_Homo sapiens_hsa052101.27586160
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26355969
43Circadian rhythm_Homo sapiens_hsa047101.22270739
44Nucleotide excision repair_Homo sapiens_hsa034201.21787212
45Regulation of autophagy_Homo sapiens_hsa041401.21120538
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18117872
47RNA degradation_Homo sapiens_hsa030181.16915374
48ErbB signaling pathway_Homo sapiens_hsa040121.16636586
49p53 signaling pathway_Homo sapiens_hsa041151.15940988
50Non-homologous end-joining_Homo sapiens_hsa034501.15652620
51Ether lipid metabolism_Homo sapiens_hsa005651.10916849
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09906133
53Axon guidance_Homo sapiens_hsa043601.09485246
54Protein export_Homo sapiens_hsa030601.09459820
55Endometrial cancer_Homo sapiens_hsa052131.08133982
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07829499
57Serotonergic synapse_Homo sapiens_hsa047261.07422603
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05099205
59ABC transporters_Homo sapiens_hsa020101.02624873
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01239842
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01093654
62Tight junction_Homo sapiens_hsa045301.00855894
63Melanogenesis_Homo sapiens_hsa049161.00572024
64Long-term potentiation_Homo sapiens_hsa047200.98694636
65Amphetamine addiction_Homo sapiens_hsa050310.95791936
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.94405568
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94313316
68Olfactory transduction_Homo sapiens_hsa047400.93911610
69Selenocompound metabolism_Homo sapiens_hsa004500.92420311
70Gastric acid secretion_Homo sapiens_hsa049710.92335200
71Choline metabolism in cancer_Homo sapiens_hsa052310.91953331
72Taste transduction_Homo sapiens_hsa047420.91832473
73Glutamatergic synapse_Homo sapiens_hsa047240.89450762
74Pathways in cancer_Homo sapiens_hsa052000.88703748
75Type II diabetes mellitus_Homo sapiens_hsa049300.88183570
76Prostate cancer_Homo sapiens_hsa052150.87283262
77Melanoma_Homo sapiens_hsa052180.85555824
78One carbon pool by folate_Homo sapiens_hsa006700.79716441
79Gap junction_Homo sapiens_hsa045400.78609260
80Estrogen signaling pathway_Homo sapiens_hsa049150.77188762
81Insulin secretion_Homo sapiens_hsa049110.76267843
82Prolactin signaling pathway_Homo sapiens_hsa049170.74789800
83GnRH signaling pathway_Homo sapiens_hsa049120.74625658
84Circadian entrainment_Homo sapiens_hsa047130.74422117
85Dopaminergic synapse_Homo sapiens_hsa047280.74162295
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73762232
87Caffeine metabolism_Homo sapiens_hsa002320.73519850
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73445616
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73274698
90Proteoglycans in cancer_Homo sapiens_hsa052050.72326239
91cAMP signaling pathway_Homo sapiens_hsa040240.72174152
92Ovarian steroidogenesis_Homo sapiens_hsa049130.71910135
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71901500
94MAPK signaling pathway_Homo sapiens_hsa040100.71845341
95Pancreatic secretion_Homo sapiens_hsa049720.71110589
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70681446
97RNA polymerase_Homo sapiens_hsa030200.69921500
98Glioma_Homo sapiens_hsa052140.69717087
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69601685
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69268667
101GABAergic synapse_Homo sapiens_hsa047270.68493052
102Bladder cancer_Homo sapiens_hsa052190.68165388
103HTLV-I infection_Homo sapiens_hsa051660.67809579
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66880960
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66087261
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66039041
107Rap1 signaling pathway_Homo sapiens_hsa040150.65932360
108Morphine addiction_Homo sapiens_hsa050320.65141649
109Alcoholism_Homo sapiens_hsa050340.64737531
110Thyroid hormone synthesis_Homo sapiens_hsa049180.64639601
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64397128
112Nitrogen metabolism_Homo sapiens_hsa009100.63329284
113Thyroid cancer_Homo sapiens_hsa052160.63095708
114AMPK signaling pathway_Homo sapiens_hsa041520.62331272
115Oxytocin signaling pathway_Homo sapiens_hsa049210.62196497
116Dilated cardiomyopathy_Homo sapiens_hsa054140.61805530
117Long-term depression_Homo sapiens_hsa047300.61063127
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60581291
119Viral carcinogenesis_Homo sapiens_hsa052030.60153505
120Small cell lung cancer_Homo sapiens_hsa052220.59289485
121Tryptophan metabolism_Homo sapiens_hsa003800.59288856
122FoxO signaling pathway_Homo sapiens_hsa040680.58672909
123Ras signaling pathway_Homo sapiens_hsa040140.57476931
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57285674
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56301093
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.56204874
127Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55935652
128Cholinergic synapse_Homo sapiens_hsa047250.55387130
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54732643
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.54178401
131Calcium signaling pathway_Homo sapiens_hsa040200.53350060
132Inositol phosphate metabolism_Homo sapiens_hsa005620.53259088
133Glucagon signaling pathway_Homo sapiens_hsa049220.52764808
134Chronic myeloid leukemia_Homo sapiens_hsa052200.52619704
135Renin secretion_Homo sapiens_hsa049240.52181840
136Renal cell carcinoma_Homo sapiens_hsa052110.51879857
137Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49046191

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »