KAT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin metabolic process (GO:0042428)6.64103955
2behavioral response to nicotine (GO:0035095)6.31059692
3primary amino compound metabolic process (GO:1901160)6.04023364
4protein localization to kinetochore (GO:0034501)5.78904571
5nuclear pore complex assembly (GO:0051292)5.33169631
6nuclear pore organization (GO:0006999)5.19604528
7neuronal action potential (GO:0019228)5.18598005
8polyketide metabolic process (GO:0030638)5.04210279
9doxorubicin metabolic process (GO:0044598)5.04210279
10daunorubicin metabolic process (GO:0044597)5.04210279
11DNA replication-dependent nucleosome organization (GO:0034723)4.94562441
12DNA replication-dependent nucleosome assembly (GO:0006335)4.94562441
13regulation of telomere maintenance via telomerase (GO:0032210)4.92393947
14mitotic sister chromatid segregation (GO:0000070)4.89698109
15protein localization to chromosome, centromeric region (GO:0071459)4.87576215
16regulation of nuclear cell cycle DNA replication (GO:0033262)4.86268130
17positive regulation of action potential (GO:0045760)4.59953073
18heterochromatin organization (GO:0070828)4.52999076
19negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.48985260
20sister chromatid segregation (GO:0000819)4.34923513
21DNA replication checkpoint (GO:0000076)4.20265219
22negative regulation of telomerase activity (GO:0051974)4.18774297
23pre-miRNA processing (GO:0031054)4.16509557
24negative regulation of cell cycle G2/M phase transition (GO:1902750)4.16030735
25indole-containing compound metabolic process (GO:0042430)4.10410474
26response to pheromone (GO:0019236)4.04796175
27cell proliferation in forebrain (GO:0021846)4.02410318
28pore complex assembly (GO:0046931)4.01266376
29DNA unwinding involved in DNA replication (GO:0006268)4.00435866
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.96306398
31regulation of mammary gland epithelial cell proliferation (GO:0033599)3.95727595
32regulation of gene silencing by RNA (GO:0060966)3.95426112
33regulation of posttranscriptional gene silencing (GO:0060147)3.95426112
34regulation of gene silencing by miRNA (GO:0060964)3.95426112
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.91815761
36regulation of translation, ncRNA-mediated (GO:0045974)3.91815761
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.91815761
38chromatin assembly (GO:0031497)3.89472310
39gamma-aminobutyric acid transport (GO:0015812)3.86757061
40mitotic chromosome condensation (GO:0007076)3.81094930
41mitotic nuclear envelope disassembly (GO:0007077)3.79443597
42* histone H4-K5 acetylation (GO:0043981)3.79041403
43* histone H4-K8 acetylation (GO:0043982)3.79041403
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.76862577
45regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.76862577
46maintenance of protein location in nucleus (GO:0051457)3.76287459
47DNA duplex unwinding (GO:0032508)3.74651331
48DNA geometric change (GO:0032392)3.72602926
49formation of translation preinitiation complex (GO:0001731)3.61985053
50DNA replication initiation (GO:0006270)3.60950850
51cytoplasmic mRNA processing body assembly (GO:0033962)3.56635169
52membrane disassembly (GO:0030397)3.54335048
53nuclear envelope disassembly (GO:0051081)3.54335048
54negative regulation of epidermis development (GO:0045683)3.49274717
55regulation of cilium movement (GO:0003352)3.45507618
56action potential (GO:0001508)3.44959851
57* histone H4-K12 acetylation (GO:0043983)3.43643708
58ribosome biogenesis (GO:0042254)3.41784441
59negative regulation of telomere maintenance (GO:0032205)3.40668448
60negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.39813371
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.37886388
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.37886388
63regulation of action potential (GO:0098900)3.37295691
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.36395432
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36395432
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.32389063
67rRNA methylation (GO:0031167)3.31663541
68rRNA modification (GO:0000154)3.30992002
69positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.30425545
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28963980
71regulation of response to osmotic stress (GO:0047484)3.28707827
72behavioral response to ethanol (GO:0048149)3.26009364
73positive regulation of DNA-dependent DNA replication (GO:2000105)3.25694074
74positive regulation of mRNA catabolic process (GO:0061014)3.21426924
75protein localization to chromosome (GO:0034502)3.19619979
76membrane depolarization during action potential (GO:0086010)3.19605894
77spindle assembly (GO:0051225)3.19272215
78regulation of histone H3-K9 methylation (GO:0051570)3.18167130
79regulation of translation in response to stress (GO:0043555)3.17528018
80RNA stabilization (GO:0043489)3.16744147
81mRNA stabilization (GO:0048255)3.16744147
82rRNA transcription (GO:0009303)3.16447184
83mitotic metaphase plate congression (GO:0007080)3.15995758
84seminiferous tubule development (GO:0072520)3.14633031
85sulfation (GO:0051923)3.14233268
86somite rostral/caudal axis specification (GO:0032525)3.14229515
87interkinetic nuclear migration (GO:0022027)3.13380178
88attachment of spindle microtubules to kinetochore (GO:0008608)3.13287964
89chromatin assembly or disassembly (GO:0006333)3.12394639
90piRNA metabolic process (GO:0034587)3.12387594
91protein polyglutamylation (GO:0018095)3.11049702
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10846049
93positive regulation of mRNA 3-end processing (GO:0031442)3.09399793
94negative regulation of histone methylation (GO:0031061)3.08825540
95negative regulation of sodium ion transport (GO:0010766)3.08520305
96regulation of mesoderm development (GO:2000380)3.08501378
97DNA methylation involved in gamete generation (GO:0043046)3.07558503
98regulation of chromosome segregation (GO:0051983)3.04108420
99regulation of double-strand break repair (GO:2000779)3.03792066
100DNA conformation change (GO:0071103)3.03525846
101endoderm formation (GO:0001706)3.00056030
102spindle assembly checkpoint (GO:0071173)2.99647850
103aminoglycoside antibiotic metabolic process (GO:0030647)2.98983532
104cilium or flagellum-dependent cell motility (GO:0001539)2.98181626
105presynaptic membrane assembly (GO:0097105)2.96710198
106kidney morphogenesis (GO:0060993)2.96395230
107parturition (GO:0007567)2.95341906
108pharyngeal system development (GO:0060037)2.94668146
109hindbrain development (GO:0030902)2.94624996
110negative regulation of chromosome segregation (GO:0051985)2.93940372
111neuron maturation (GO:0042551)2.93844113
112chromosome condensation (GO:0030261)2.92283607
113ovulation cycle (GO:0042698)2.91790337
114NLS-bearing protein import into nucleus (GO:0006607)2.90942391
115regulation of telomere maintenance (GO:0032204)2.89954190
116postsynaptic membrane organization (GO:0001941)2.89485298
117regulation of acrosome reaction (GO:0060046)2.89295684
118positive regulation of mRNA processing (GO:0050685)2.87685912
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85865018
120negative regulation of sister chromatid segregation (GO:0033046)2.85865018
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.85865018
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85865018
123DNA strand elongation involved in DNA replication (GO:0006271)2.85370704
124notochord development (GO:0030903)2.84697624
125somite development (GO:0061053)2.84321453
126histone arginine methylation (GO:0034969)2.83858907
127regulation of DNA-dependent DNA replication (GO:0090329)2.83781598
128positive regulation of chromosome segregation (GO:0051984)2.83450675
129glycerophospholipid catabolic process (GO:0046475)2.83433828
130DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.82731919
131regulation of gene silencing (GO:0060968)2.82501722
132mitotic spindle assembly checkpoint (GO:0007094)2.81662053
133* histone H4-K16 acetylation (GO:0043984)2.80793101
134neuron cell-cell adhesion (GO:0007158)2.80444713
135cardiovascular system development (GO:0072358)2.80224084
136trophectodermal cell differentiation (GO:0001829)2.79192404
137positive regulation of sodium ion transmembrane transport (GO:1902307)2.78083703
138negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78034666
139kynurenine metabolic process (GO:0070189)2.77534613
140spinal cord motor neuron differentiation (GO:0021522)2.77303080
141negative regulation of gene silencing (GO:0060969)2.76389090
142determination of adult lifespan (GO:0008340)2.75993144
143DNA replication-independent nucleosome assembly (GO:0006336)2.75894390
144DNA replication-independent nucleosome organization (GO:0034724)2.75894390
145positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75870603
146positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75870603
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.75870603
148spindle checkpoint (GO:0031577)2.75458344
149cellular response to ATP (GO:0071318)2.75428709
150negative regulation of systemic arterial blood pressure (GO:0003085)2.75332106
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74491758
152gene silencing by RNA (GO:0031047)2.74230874
153negative regulation of epidermal cell differentiation (GO:0045605)2.73664155
154regulation of double-strand break repair via homologous recombination (GO:0010569)2.73658767
155phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73392449
156regulation of mRNA 3-end processing (GO:0031440)2.72952907
157chromatin remodeling at centromere (GO:0031055)2.72352328
158chromosome segregation (GO:0007059)2.71074665
159snRNA transcription (GO:0009301)2.70671784
160positive regulation of mRNA metabolic process (GO:1903313)2.69423291
161ionotropic glutamate receptor signaling pathway (GO:0035235)2.68944858
162replication fork processing (GO:0031297)2.67203874
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.65377530
164forebrain neuron differentiation (GO:0021879)2.64656629
165L-fucose catabolic process (GO:0042355)2.64584425
166fucose catabolic process (GO:0019317)2.64584425
167L-fucose metabolic process (GO:0042354)2.64584425
168presynaptic membrane organization (GO:0097090)2.64193519
169phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.61952844
170neuronal action potential propagation (GO:0019227)2.61724862
171protein localization to synapse (GO:0035418)2.61569795
172otic vesicle formation (GO:0030916)2.60281643
173peristalsis (GO:0030432)2.60043810
174tryptophan catabolic process (GO:0006569)2.58847646
175indole-containing compound catabolic process (GO:0042436)2.58847646
176indolalkylamine catabolic process (GO:0046218)2.58847646
177neuron remodeling (GO:0016322)2.58335291
178spinal cord development (GO:0021510)2.58003568
179glutamate receptor signaling pathway (GO:0007215)2.57882123
180regulation of mRNA catabolic process (GO:0061013)2.56937420
181negative regulation of DNA-dependent DNA replication (GO:2000104)2.53445960
182detection of light stimulus involved in visual perception (GO:0050908)2.53029987
183detection of light stimulus involved in sensory perception (GO:0050962)2.53029987
184water-soluble vitamin biosynthetic process (GO:0042364)2.52048201
185cornea development in camera-type eye (GO:0061303)2.51755057
186regulation of potassium ion transmembrane transport (GO:1901379)2.51342879
187cerebellar Purkinje cell differentiation (GO:0021702)2.50386277
188indolalkylamine metabolic process (GO:0006586)2.48686041
189reflex (GO:0060004)2.47842083
190regulation of meiosis I (GO:0060631)2.47720869
191positive regulation of synapse assembly (GO:0051965)2.47507554
192auditory behavior (GO:0031223)2.46403831
193tongue development (GO:0043586)2.46083706
194cell differentiation in spinal cord (GO:0021515)2.45822497
195negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45495186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.71444377
2EZH2_22144423_ChIP-Seq_EOC_Human6.11141775
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.20688348
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.04822577
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.04822577
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.04822577
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47957419
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.47039930
9GBX2_23144817_ChIP-Seq_PC3_Human3.21606397
10ZNF274_21170338_ChIP-Seq_K562_Hela3.15192573
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06438200
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.01105951
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.99934517
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92337176
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85449947
16VDR_22108803_ChIP-Seq_LS180_Human2.78786641
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.75421312
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.67522103
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.63315018
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58633948
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54220001
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.47782981
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.44539603
24TP63_19390658_ChIP-ChIP_HaCaT_Human2.35548623
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29248476
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24831490
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20676656
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14948093
29EWS_26573619_Chip-Seq_HEK293_Human2.13995843
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08933985
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.06788617
32TAF15_26573619_Chip-Seq_HEK293_Human2.05559225
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03305171
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00709579
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97502958
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96997198
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95445983
38IRF1_19129219_ChIP-ChIP_H3396_Human1.94278745
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.93756766
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92434859
41REST_21632747_ChIP-Seq_MESCs_Mouse1.91750690
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91085578
43MYC_22102868_ChIP-Seq_BL_Human1.89132975
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86610495
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86592100
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.85466466
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84875271
48P300_19829295_ChIP-Seq_ESCs_Human1.82419376
49FUS_26573619_Chip-Seq_HEK293_Human1.81788596
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.81446140
51TCF3_18692474_ChIP-Seq_MESCs_Mouse1.79637106
52RNF2_27304074_Chip-Seq_NSC_Mouse1.79622452
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79128265
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79010671
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77575634
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75593746
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75155419
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73013399
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.69830661
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.69639349
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68020549
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67566357
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65844751
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65841420
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63735204
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.63284245
67IGF1R_20145208_ChIP-Seq_DFB_Human1.61860063
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60335123
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60335123
70XRN2_22483619_ChIP-Seq_HELA_Human1.59541728
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58672413
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58546212
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57347793
74STAT3_23295773_ChIP-Seq_U87_Human1.56031032
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55924438
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.55898614
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53684286
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.53484194
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.52233810
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51378588
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.50789034
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50171824
83AR_21909140_ChIP-Seq_LNCAP_Human1.48995677
84SMAD4_21799915_ChIP-Seq_A2780_Human1.48722512
85AR_25329375_ChIP-Seq_VCAP_Human1.47609162
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47280439
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46786750
88CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46750630
89AR_21572438_ChIP-Seq_LNCaP_Human1.45085829
90* CIITA_25753668_ChIP-Seq_RAJI_Human1.44788525
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44109526
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43912086
93FOXP3_21729870_ChIP-Seq_TREG_Human1.42755094
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.40569808
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40453697
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.39475133
97ER_23166858_ChIP-Seq_MCF-7_Human1.39159528
98TCF4_23295773_ChIP-Seq_U87_Human1.38376359
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.37857291
100RUNX2_22187159_ChIP-Seq_PCA_Human1.37711954
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.34757111
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.34493433
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.34441328
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.34105785
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34046593
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32655306
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31990669
108JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31860446
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30923072
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30376178
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.29299300
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28598816
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27765456
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27729560
115POU5F1_16518401_ChIP-PET_MESCs_Mouse1.27533650
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27420008
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27403561
118E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26581742
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26338951
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.24982507
121EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24487005
122RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24487005
123MYC_18940864_ChIP-ChIP_HL60_Human1.24280916
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24107548
125GABP_19822575_ChIP-Seq_HepG2_Human1.23241232
126VDR_23849224_ChIP-Seq_CD4+_Human1.21730678
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21613245
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21561201
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20751679
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.19370362
131SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19070783
132POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.18510170
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17751709
134ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17359088
135* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17126743
136KDM5A_27292631_Chip-Seq_BREAST_Human1.16526153
137SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16343166
138TTF2_22483619_ChIP-Seq_HELA_Human1.15804084
139SMAD4_21741376_ChIP-Seq_EPCs_Human1.15228388
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14345034
141TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13646506
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12754576
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10872239
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09806059
145HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.09088002
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08912810
147NANOG_18692474_ChIP-Seq_MESCs_Mouse1.08127580
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08064451
149BCAT_22108803_ChIP-Seq_LS180_Human1.07812422
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07695072
151POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07468620
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07106960
153YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06969735
154THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06803047
155SOX2_21211035_ChIP-Seq_LN229_Gbm1.06501793
156CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05971991
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04808544
158CBP_20019798_ChIP-Seq_JUKART_Human1.04808544
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04745341
160KDM2B_26808549_Chip-Seq_REH_Human1.04586623
161DROSHA_22980978_ChIP-Seq_HELA_Human1.04148465
162SMAD3_21741376_ChIP-Seq_ESCs_Human1.03987532
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03795397
164DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03497450
165TAL1_26923725_Chip-Seq_HPCs_Mouse1.03028406
166GABP_17652178_ChIP-ChIP_JURKAT_Human1.01890459
167SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01752383
168TP53_16413492_ChIP-PET_HCT116_Human1.01573109
169ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01357392
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01315151
171NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01192821
172OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01160848
173KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00766401
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99551893
175FOXA1_25329375_ChIP-Seq_VCAP_Human0.99450488
176FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99450488
177SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98994927
178ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98828578
179PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98805442
180FLI1_21867929_ChIP-Seq_TH2_Mouse0.98057792
181GATA1_26923725_Chip-Seq_HPCs_Mouse0.98002749
182TCF7_22412390_ChIP-Seq_EML_Mouse0.97928514
183JUN_21703547_ChIP-Seq_K562_Human0.97684600
184SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97048954
185TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96794877
186MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96610883
187PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96116754
188RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95862152
189HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95429227
190ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95086574
191TFEB_21752829_ChIP-Seq_HELA_Human0.95021855
192NOTCH1_21737748_ChIP-Seq_TLL_Human0.94332461
193SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91100129
194DCP1A_22483619_ChIP-Seq_HELA_Human0.89194966
195KAP1_27257070_Chip-Seq_ESCs_Mouse0.86861774
196TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86256072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.62930726
2MP0004957_abnormal_blastocyst_morpholog3.72803783
3MP0003111_abnormal_nucleus_morphology3.43807391
4MP0010094_abnormal_chromosome_stability3.35504203
5MP0003693_abnormal_embryo_hatching3.14696104
6MP0003077_abnormal_cell_cycle3.12096974
7MP0002653_abnormal_ependyma_morphology3.04019367
8MP0004264_abnormal_extraembryonic_tissu2.96994485
9MP0003646_muscle_fatigue2.96667713
10MP0010352_gastrointestinal_tract_polyps2.93657976
11MP0003890_abnormal_embryonic-extraembry2.87923395
12MP0006292_abnormal_olfactory_placode2.46839126
13MP0001968_abnormal_touch/_nociception2.45966248
14MP0008058_abnormal_DNA_repair2.42453470
15MP0009745_abnormal_behavioral_response2.38786531
16MP0008007_abnormal_cellular_replicative2.29003184
17MP0003121_genomic_imprinting2.24153422
18MP0000350_abnormal_cell_proliferation2.22568335
19MP0003123_paternal_imprinting2.17896033
20MP0004885_abnormal_endolymph2.14775002
21MP0002272_abnormal_nervous_system2.12121156
22MP0001672_abnormal_embryogenesis/_devel2.12116189
23MP0005380_embryogenesis_phenotype2.12116189
24MP0008877_abnormal_DNA_methylation2.10037188
25MP0001730_embryonic_growth_arrest2.07022768
26MP0002160_abnormal_reproductive_system2.06601608
27MP0001986_abnormal_taste_sensitivity1.98125084
28MP0008932_abnormal_embryonic_tissue1.96196625
29MP0005394_taste/olfaction_phenotype1.93622313
30MP0005499_abnormal_olfactory_system1.93622313
31MP0003984_embryonic_growth_retardation1.90383332
32MP0002088_abnormal_embryonic_growth/wei1.88771824
33MP0002064_seizures1.88588014
34MP0003880_abnormal_central_pattern1.85978603
35MP0004142_abnormal_muscle_tone1.81464932
36MP0009046_muscle_twitch1.81063604
37MP0002837_dystrophic_cardiac_calcinosis1.77639145
38MP0002085_abnormal_embryonic_tissue1.77620498
39MP0002254_reproductive_system_inflammat1.77433467
40MP0003195_calcinosis1.77127220
41MP0005075_abnormal_melanosome_morpholog1.76862033
42MP0005389_reproductive_system_phenotype1.76801974
43MP0005551_abnormal_eye_electrophysiolog1.75955468
44MP0002084_abnormal_developmental_patter1.74409969
45MP0010030_abnormal_orbit_morphology1.73905994
46MP0000569_abnormal_digit_pigmentation1.72664237
47MP0003635_abnormal_synaptic_transmissio1.72185251
48MP0002102_abnormal_ear_morphology1.71118092
49MP0003122_maternal_imprinting1.70751544
50MP0002396_abnormal_hematopoietic_system1.70375445
51MP0003136_yellow_coat_color1.70341008
52MP0002735_abnormal_chemical_nociception1.70297186
53MP0005646_abnormal_pituitary_gland1.69263496
54MP0002086_abnormal_extraembryonic_tissu1.69011084
55MP0002734_abnormal_mechanical_nocicepti1.68822854
56MP0000631_abnormal_neuroendocrine_gland1.68240693
57MP0001486_abnormal_startle_reflex1.68165569
58MP0001485_abnormal_pinna_reflex1.66930538
59MP0009379_abnormal_foot_pigmentation1.65720436
60MP0003705_abnormal_hypodermis_morpholog1.65497548
61MP0005410_abnormal_fertilization1.63347587
62MP0001697_abnormal_embryo_size1.58546712
63MP0003011_delayed_dark_adaptation1.57337582
64MP0000427_abnormal_hair_cycle1.57195303
65MP0003786_premature_aging1.57171698
66MP0004197_abnormal_fetal_growth/weight/1.56193170
67MP0002736_abnormal_nociception_after1.53934305
68MP0001849_ear_inflammation1.53644736
69MP0001293_anophthalmia1.50513925
70MP0002733_abnormal_thermal_nociception1.49573558
71MP0000778_abnormal_nervous_system1.49096781
72MP0002063_abnormal_learning/memory/cond1.46731264
73MP0005423_abnormal_somatic_nervous1.46276494
74MP0004145_abnormal_muscle_electrophysio1.46209645
75MP0002572_abnormal_emotion/affect_behav1.44954066
76MP0002080_prenatal_lethality1.43477316
77MP0001440_abnormal_grooming_behavior1.40384954
78MP0001929_abnormal_gametogenesis1.38396100
79MP0004742_abnormal_vestibular_system1.38272136
80MP0000313_abnormal_cell_death1.37869842
81MP0010307_abnormal_tumor_latency1.37859116
82MP0002210_abnormal_sex_determination1.37461944
83MP0001145_abnormal_male_reproductive1.34790543
84MP0004133_heterotaxia1.31634332
85MP0000490_abnormal_crypts_of1.30986861
86MP0002067_abnormal_sensory_capabilities1.30592272
87MP0008872_abnormal_physiological_respon1.30068165
88MP0004858_abnormal_nervous_system1.29525460
89MP0001970_abnormal_pain_threshold1.25828324
90MP0002184_abnormal_innervation1.25290430
91MP0004130_abnormal_muscle_cell1.24967622
92MP0003119_abnormal_digestive_system1.24342184
93MP0005187_abnormal_penis_morphology1.24029989
94MP0005645_abnormal_hypothalamus_physiol1.23845332
95MP0001188_hyperpigmentation1.22002189
96MP0004924_abnormal_behavior1.19792946
97MP0005386_behavior/neurological_phenoty1.19792946
98MP0000678_abnormal_parathyroid_gland1.16415365
99MP0002557_abnormal_social/conspecific_i1.16066506
100MP0004270_analgesia1.15683282
101MP0003698_abnormal_male_reproductive1.15122853
102MP0005076_abnormal_cell_differentiation1.13752973
103MP0008961_abnormal_basal_metabolism1.13188671
104MP0002092_abnormal_eye_morphology1.12986266
105MP0003787_abnormal_imprinting1.12311839
106MP0001919_abnormal_reproductive_system1.10542622
107MP0004147_increased_porphyrin_level1.10401926
108MP0003283_abnormal_digestive_organ1.10387522
109MP0002332_abnormal_exercise_endurance1.08783322
110MP0004043_abnormal_pH_regulation1.07967763
111MP0000955_abnormal_spinal_cord1.05804431
112MP0004808_abnormal_hematopoietic_stem1.05672156
113MP0002019_abnormal_tumor_incidence1.05055373
114MP0005257_abnormal_intraocular_pressure1.04592113
115MP0006276_abnormal_autonomic_nervous1.03270701
116MP0003938_abnormal_ear_development1.02984176
117MP0006035_abnormal_mitochondrial_morpho1.01180614
118MP0000653_abnormal_sex_gland0.97819263
119MP0002277_abnormal_respiratory_mucosa0.97653338
120MP0000428_abnormal_craniofacial_morphol0.97277020
121MP0008789_abnormal_olfactory_epithelium0.96668920
122MP0002876_abnormal_thyroid_physiology0.96150489
123MP0003183_abnormal_peptide_metabolism0.95739701
124MP0003942_abnormal_urinary_system0.95701465
125MP0003315_abnormal_perineum_morphology0.92728547
126MP0002882_abnormal_neuron_morphology0.92026493
127MP0005195_abnormal_posterior_eye0.91918934
128MP0002152_abnormal_brain_morphology0.91307541
129MP0005384_cellular_phenotype0.90870715
130MP0005174_abnormal_tail_pigmentation0.90630005
131MP0002752_abnormal_somatic_nervous0.90518711
132MP0009703_decreased_birth_body0.90514136
133MP0002932_abnormal_joint_morphology0.90206191
134MP0003718_maternal_effect0.89945940
135MP0001501_abnormal_sleep_pattern0.89801768
136MP0002877_abnormal_melanocyte_morpholog0.88409146
137MP0002938_white_spotting0.86947304
138MP0005023_abnormal_wound_healing0.86838650
139MP0000358_abnormal_cell_content/0.86628667
140MP0008770_decreased_survivor_rate0.86003226
141MP0000026_abnormal_inner_ear0.85267901
142MP0000432_abnormal_head_morphology0.85202336
143MP0001963_abnormal_hearing_physiology0.84556253
144MP0003861_abnormal_nervous_system0.84046413
145MP0002114_abnormal_axial_skeleton0.83290990
146MP0000703_abnormal_thymus_morphology0.82738302
147MP0006072_abnormal_retinal_apoptosis0.82208087
148MP0005266_abnormal_metabolism0.81903086
149MP0003935_abnormal_craniofacial_develop0.81442266
150MP0002925_abnormal_cardiovascular_devel0.81379356
151MP0005621_abnormal_cell_physiology0.81089694
152MP0002638_abnormal_pupillary_reflex0.80008782
153MP0002127_abnormal_cardiovascular_syste0.79631659
154MP0003937_abnormal_limbs/digits/tail_de0.79467334
155MP0005253_abnormal_eye_physiology0.78537650
156MP0003567_abnormal_fetal_cardiomyocyte0.78255371
157MP0001324_abnormal_eye_pigmentation0.77361220
158MP0000049_abnormal_middle_ear0.77353553
159MP0005623_abnormal_meninges_morphology0.76714330
160MP0002161_abnormal_fertility/fecundity0.76531056
161MP0002234_abnormal_pharynx_morphology0.76505427
162MP0004859_abnormal_synaptic_plasticity0.76133955
163MP0001664_abnormal_digestion0.74882181
164MP0008995_early_reproductive_senescence0.74600501
165MP0002233_abnormal_nose_morphology0.72723863
166MP0002111_abnormal_tail_morphology0.69513361
167MP0002075_abnormal_coat/hair_pigmentati0.68724672
168MP0002970_abnormal_white_adipose0.67959415
169MP0005391_vision/eye_phenotype0.67233857
170MP0003755_abnormal_palate_morphology0.67074490
171MP0003566_abnormal_cell_adhesion0.66800785
172MP0002751_abnormal_autonomic_nervous0.65308090
173MP0001545_abnormal_hematopoietic_system0.65112702
174MP0005397_hematopoietic_system_phenotyp0.65112702

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.26904247
2Abnormality of the lower motor neuron (HP:0002366)4.56543006
3Bilateral microphthalmos (HP:0007633)4.55241975
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.16184051
5Hyperventilation (HP:0002883)3.88742690
6Astrocytoma (HP:0009592)3.83105428
7Abnormality of the astrocytes (HP:0100707)3.83105428
8Protruding tongue (HP:0010808)3.83035334
9Chromsome breakage (HP:0040012)3.80564274
10Rhabdomyosarcoma (HP:0002859)3.80027918
11Neoplasm of striated muscle (HP:0009728)3.70112535
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.67692320
13Abnormality of alanine metabolism (HP:0010916)3.67692320
14Hyperalaninemia (HP:0003348)3.67692320
15Medulloblastoma (HP:0002885)3.66303692
16Rib fusion (HP:0000902)3.60691210
17Pancreatic cysts (HP:0001737)3.54597258
18Nephroblastoma (Wilms tumor) (HP:0002667)3.25619567
19Glioma (HP:0009733)3.25571318
20Pancreatic fibrosis (HP:0100732)3.23832777
21Abnormality of midbrain morphology (HP:0002418)3.20406377
22Molar tooth sign on MRI (HP:0002419)3.20406377
23Nephronophthisis (HP:0000090)3.13920114
24Progressive cerebellar ataxia (HP:0002073)3.11556914
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.11498007
26Genetic anticipation (HP:0003743)3.10072000
27Congenital stationary night blindness (HP:0007642)3.09251700
28Multiple enchondromatosis (HP:0005701)3.03870822
29Meckel diverticulum (HP:0002245)3.03614668
30True hermaphroditism (HP:0010459)3.02487694
31Impulsivity (HP:0100710)3.01963039
32Amyotrophic lateral sclerosis (HP:0007354)3.01625368
33Embryonal renal neoplasm (HP:0011794)3.00777404
34Abnormality of the ileum (HP:0001549)2.93536254
35Hypochromic microcytic anemia (HP:0004840)2.93389877
36Osteomalacia (HP:0002749)2.87305234
37Inability to walk (HP:0002540)2.83714460
38Selective tooth agenesis (HP:0001592)2.82668539
39Supernumerary spleens (HP:0009799)2.79849094
40Broad-based gait (HP:0002136)2.79689756
41Gaze-evoked nystagmus (HP:0000640)2.78130690
42Aplasia/hypoplasia of the humerus (HP:0006507)2.74093188
43Congenital, generalized hypertrichosis (HP:0004540)2.72508435
44Drooling (HP:0002307)2.70803241
45Neoplasm of the oral cavity (HP:0100649)2.70056051
46Short humerus (HP:0005792)2.66265428
47Clumsiness (HP:0002312)2.65942081
48Abnormality of the renal medulla (HP:0100957)2.64388056
49Hepatoblastoma (HP:0002884)2.64276969
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.59135506
51Abnormal lung lobation (HP:0002101)2.57097968
52Abnormality of the axillary hair (HP:0100134)2.56868965
53Abnormality of secondary sexual hair (HP:0009888)2.56868965
54Progressive inability to walk (HP:0002505)2.54858066
55Duodenal stenosis (HP:0100867)2.54777071
56Small intestinal stenosis (HP:0012848)2.54777071
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.54193122
58Increased nuchal translucency (HP:0010880)2.52902308
59Renal duplication (HP:0000075)2.51434266
60Abnormality of the anterior horn cell (HP:0006802)2.49046296
61Degeneration of anterior horn cells (HP:0002398)2.49046296
62Tubular atrophy (HP:0000092)2.47410630
63Abnormality of the salivary glands (HP:0010286)2.47306903
64Excessive salivation (HP:0003781)2.46147528
65Pendular nystagmus (HP:0012043)2.44569179
66Rectovaginal fistula (HP:0000143)2.39665572
67Rectal fistula (HP:0100590)2.39665572
68Abnormality of chromosome stability (HP:0003220)2.36929788
69Focal motor seizures (HP:0011153)2.35018002
70Volvulus (HP:0002580)2.33454753
71Medial flaring of the eyebrow (HP:0010747)2.33444982
72Preauricular skin tag (HP:0000384)2.32022543
73Congenital sensorineural hearing impairment (HP:0008527)2.31587293
74Chorioretinal atrophy (HP:0000533)2.31285115
75Trismus (HP:0000211)2.30443566
76Abnormality of the preputium (HP:0100587)2.28969763
77Abnormality of the nasal septum (HP:0000419)2.27631187
78Abnormality of the labia minora (HP:0012880)2.26864375
79Skin tags (HP:0010609)2.26856623
80Fused cervical vertebrae (HP:0002949)2.26201004
81Intestinal fistula (HP:0100819)2.25444579
82Missing ribs (HP:0000921)2.24448330
83Spinal muscular atrophy (HP:0007269)2.24032895
84Abnormal respiratory motile cilium morphology (HP:0005938)2.22338858
85Abnormal respiratory epithelium morphology (HP:0012253)2.22338858
86Abnormality of the renal collecting system (HP:0004742)2.21456035
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19587765
88Sloping forehead (HP:0000340)2.18641253
89Abolished electroretinogram (ERG) (HP:0000550)2.16640427
90Agnosia (HP:0010524)2.15020347
91Furrowed tongue (HP:0000221)2.14909712
92Myelodysplasia (HP:0002863)2.14199489
93Nasal polyposis (HP:0100582)2.13221035
94Cystic liver disease (HP:0006706)2.13186805
95Hand muscle atrophy (HP:0009130)2.11905350
96Type II lissencephaly (HP:0007260)2.11000924
97Prominent nose (HP:0000448)2.10417370
98Partial agenesis of the corpus callosum (HP:0001338)2.09556015
99Male pseudohermaphroditism (HP:0000037)2.08932304
100Focal seizures (HP:0007359)2.08728142
101Ventricular fibrillation (HP:0001663)2.08530702
102Abnormality of chromosome segregation (HP:0002916)2.07957438
103Abnormality of the duodenum (HP:0002246)2.07064453
104Aplasia/Hypoplasia of the sternum (HP:0006714)2.06871810
105Sclerocornea (HP:0000647)2.06347535
106Shawl scrotum (HP:0000049)2.04917349
107Abnormality of the vertebral endplates (HP:0005106)2.04365186
108Tongue fasciculations (HP:0001308)2.04290531
109Upper motor neuron abnormality (HP:0002127)2.03515917
110Small hand (HP:0200055)2.03359386
111Irregular vertebral endplates (HP:0003301)2.02523451
112Abnormality of the carotid arteries (HP:0005344)2.02149231
113Malignant neoplasm of the central nervous system (HP:0100836)2.01935340
114Febrile seizures (HP:0002373)2.00671650
115Supernumerary ribs (HP:0005815)2.00568323
116Premature ovarian failure (HP:0008209)1.99434503
117Atresia of the external auditory canal (HP:0000413)1.98755826
118Facial cleft (HP:0002006)1.98440100
119Vaginal fistula (HP:0004320)1.97841860
120Hypopigmentation of the fundus (HP:0007894)1.97106195
121Patellar aplasia (HP:0006443)1.96916692
122Birth length less than 3rd percentile (HP:0003561)1.96446364
123Short hallux (HP:0010109)1.96125215
124Absent/shortened dynein arms (HP:0200106)1.95876479
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.95876479
126Aplastic anemia (HP:0001915)1.93768871
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93151236
128Bifid tongue (HP:0010297)1.92145173
129Gait imbalance (HP:0002141)1.91653084
130Ectopic kidney (HP:0000086)1.89523548
131Abnormality of the renal cortex (HP:0011035)1.89163405
132Supernumerary bones of the axial skeleton (HP:0009144)1.88164194
133Curly hair (HP:0002212)1.87290830
134Abnormal number of incisors (HP:0011064)1.87149589
135Progressive muscle weakness (HP:0003323)1.86534020
136Attenuation of retinal blood vessels (HP:0007843)1.86488788
137Optic nerve hypoplasia (HP:0000609)1.86460996
138Tracheoesophageal fistula (HP:0002575)1.86086244
139Heterotopia (HP:0002282)1.85342323
140Bone marrow hypocellularity (HP:0005528)1.85045219
141Pseudobulbar signs (HP:0002200)1.84937610
142Increased corneal curvature (HP:0100692)1.84924262
143Keratoconus (HP:0000563)1.84924262
144Cafe-au-lait spot (HP:0000957)1.84523230
145Muscle fibrillation (HP:0010546)1.84275371
146Abnormality of abdominal situs (HP:0011620)1.84266185
147Abdominal situs inversus (HP:0003363)1.84266185
148Hemiparesis (HP:0001269)1.84018715
149Dialeptic seizures (HP:0011146)1.83899978
150Vertebral fusion (HP:0002948)1.83302241
151Abnormality of cochlea (HP:0000375)1.83103758
152Epileptic encephalopathy (HP:0200134)1.82710615
153Abnormality of the musculature of the hand (HP:0001421)1.82446878
154Aplasia/Hypoplasia of the hallux (HP:0008362)1.82069271
155Large for gestational age (HP:0001520)1.80464151
156Absent radius (HP:0003974)1.80175149
157Abnormal neuron morphology (HP:0012757)1.79511607
158Abnormality of the motor neurons (HP:0002450)1.79511607
159Aplasia/Hypoplasia of the patella (HP:0006498)1.79285804
160Anencephaly (HP:0002323)1.79227459
161Fair hair (HP:0002286)1.78868344
162Inappropriate behavior (HP:0000719)1.78789675
163Congenital primary aphakia (HP:0007707)1.78635664
164Carpal bone hypoplasia (HP:0001498)1.77807891
165Breast hypoplasia (HP:0003187)1.77666831
166Anophthalmia (HP:0000528)1.77220821
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77150212
168Embryonal neoplasm (HP:0002898)1.76864554
169Horizontal nystagmus (HP:0000666)1.76660946
170Scrotal hypoplasia (HP:0000046)1.75735222
171Neoplasm of the heart (HP:0100544)1.75629461
172Morphological abnormality of the middle ear (HP:0008609)1.75542619
173Concave nail (HP:0001598)1.73479181
174Abnormal pancreas size (HP:0012094)1.72453707
175Ulnar claw (HP:0001178)1.71733501
176Hip contracture (HP:0003273)1.71614841
177Stenosis of the external auditory canal (HP:0000402)1.70797344
178Genital tract atresia (HP:0001827)1.70427550
179Angiofibromas (HP:0010615)1.69303856
180Adenoma sebaceum (HP:0009720)1.69303856
181Aplasia/Hypoplasia of the fovea (HP:0008060)1.68705460
182Maternal diabetes (HP:0009800)1.68229586
183Chronic hepatic failure (HP:0100626)1.68080236
184Polydipsia (HP:0001959)1.67906986
185Abnormal drinking behavior (HP:0030082)1.67906986
186Preaxial foot polydactyly (HP:0001841)1.67447452
187Vaginal atresia (HP:0000148)1.66781481
188Hyperglycinemia (HP:0002154)1.65905601
189Nephrogenic diabetes insipidus (HP:0009806)1.65805891
190Atonic seizures (HP:0010819)1.65440055
191Acute lymphatic leukemia (HP:0006721)1.65166674
192Lissencephaly (HP:0001339)1.64261307
193Aplasia/Hypoplasia of the tongue (HP:0010295)1.63980132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.20213546
2FRK5.31768626
3CASK3.96611156
4BMPR1B3.40439806
5TTK3.31283795
6CDC72.83840710
7WEE12.65630808
8ERN12.56643634
9GRK62.52791527
10SIK22.52151062
11NEK22.43498850
12GRK52.32021514
13BUB12.30795347
14TYRO32.29020427
15EPHA22.15242816
16CDK72.08247716
17STK102.07053651
18INSRR1.95400198
19CSF1R1.86052282
20MKNK21.82933074
21MAP3K41.82763549
22MATK1.77704491
23* PLK11.76459720
24MAP3K101.76299040
25CHEK21.74688484
26WNK31.73444433
27NUAK11.60256322
28PDK31.57979469
29PDK41.57979469
30NEK11.57097707
31MARK11.55855678
32TAOK31.52877947
33PAK41.51904967
34NTRK31.49789599
35TNIK1.49651548
36MAPK131.48669797
37SGK21.46820479
38EEF2K1.43737664
39PINK11.41969422
40RPS6KB21.41544241
41CHEK11.39872266
42NTRK21.31121767
43GRK11.30762504
44WNK41.25638407
45ADRBK21.23275908
46MAPKAPK31.21820163
47MAPK71.20602808
48BRD41.19256705
49ATR1.18101306
50SGK2231.17656378
51SGK4941.17656378
52DAPK21.16732112
53DYRK31.16102436
54PRKCG1.14932362
55TGFBR21.13590633
56PASK1.12789706
57TSSK61.11251459
58ICK1.10994144
59PLK41.09120811
60OXSR11.08390444
61ALK1.05496192
62ACVR1B1.02849696
63CAMK1G1.01868011
64CDK41.01580793
65DYRK21.01577182
66AURKB0.99622968
67MAP2K70.99426351
68SIK30.96510214
69MOS0.95953010
70MTOR0.94083984
71CDK190.93842452
72PIK3CA0.91619769
73AURKA0.88567222
74SRPK10.87550543
75PRKG20.87490329
76PDK20.87085244
77MAP3K90.86337173
78TESK20.85505532
79* CDK20.85227749
80TAOK20.85177202
81ATM0.84042175
82PLK20.82765314
83BRSK20.82049982
84TIE10.81580952
85STK390.78619589
86TRIM280.77472645
87RPS6KA50.77413756
88WNK10.77135886
89CAMKK20.75278885
90MKNK10.75022731
91RPS6KA60.73700915
92BRSK10.72172070
93CAMK2A0.71490470
94MAP3K80.70923867
95PRKCE0.70195371
96AKT20.69630621
97CDK30.69137741
98AKT30.68785097
99PLK30.68743753
100MAPK150.68619009
101PTK2B0.68160772
102CAMK10.66290871
103LATS20.66098666
104SCYL20.65063077
105STK110.62659812
106SGK10.62541198
107FLT30.61069101
108PRKD30.60741684
109CAMK40.60354126
110PRPF4B0.60195393
111FGFR30.60044288
112PRKCQ0.59879551
113SGK30.58734249
114TLK10.58705348
115PRKCI0.57441586
116PAK10.56715594
117CSNK1G20.56712374
118CAMK1D0.56076024
119PKN10.56056957
120PRKCZ0.54553467
121* CDK10.54095726
122MAP4K20.52882835
123PAK30.49248151
124GRK70.48077859
125CHUK0.48037690
126CCNB10.46783583
127ZAK0.46454988
128PRKACA0.45914370
129IRAK10.45768211
130TESK10.45140889
131MARK20.44855138
132HIPK20.44173222
133ERBB20.42561571
134MAP2K60.41544226
135CAMK2B0.40358751
136MAP2K10.40093453
137STK40.39940895
138MAP2K40.39593420
139CSNK1D0.39192404
140CSNK1E0.38919083
141TEC0.38475361
142PDGFRA0.36831194
143MUSK0.36114127
144PNCK0.35353293
145NTRK10.34228029
146VRK10.33303638
147TGFBR10.33186661
148CSNK1G10.33007124
149EIF2AK10.32993958
150MELK0.32902086
151TAF10.32350631
152MAPK140.32059776
153CSNK1A10.31846024
154STK30.31177550
155GSK3B0.30437853
156KSR10.28831081
157MAPK100.28037135
158DYRK1A0.27071890
159STK240.26950397
160CAMKK10.26920082
161MAPK10.26646510
162ADRBK10.26620519
163RPS6KA30.25311810
164PIM10.24828554
165KIT0.24526012
166AKT10.24152885
167PRKAA10.24113494
168RPS6KA40.23866853
169UHMK10.23691320
170CDK180.23457955
171STK380.22480772

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89198540
2Nicotine addiction_Homo sapiens_hsa050333.80350608
3DNA replication_Homo sapiens_hsa030303.70254725
4RNA transport_Homo sapiens_hsa030133.21267652
5Mismatch repair_Homo sapiens_hsa034303.17435440
6Vitamin B6 metabolism_Homo sapiens_hsa007502.88664863
7Cell cycle_Homo sapiens_hsa041102.74408160
8Phototransduction_Homo sapiens_hsa047442.60317790
9Spliceosome_Homo sapiens_hsa030402.57598256
10Fanconi anemia pathway_Homo sapiens_hsa034602.56583094
11mRNA surveillance pathway_Homo sapiens_hsa030152.39151380
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37027986
13Base excision repair_Homo sapiens_hsa034102.32121215
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.26396109
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.13361894
16Homologous recombination_Homo sapiens_hsa034402.12071708
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07625385
18Nitrogen metabolism_Homo sapiens_hsa009102.04744347
19Taste transduction_Homo sapiens_hsa047422.02668165
20Ether lipid metabolism_Homo sapiens_hsa005652.00819284
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94424494
22One carbon pool by folate_Homo sapiens_hsa006701.86096346
23Glutamatergic synapse_Homo sapiens_hsa047241.84410616
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82052854
25Nucleotide excision repair_Homo sapiens_hsa034201.80264681
26Morphine addiction_Homo sapiens_hsa050321.78664634
27Olfactory transduction_Homo sapiens_hsa047401.76628526
28Basal transcription factors_Homo sapiens_hsa030221.72545051
29Circadian entrainment_Homo sapiens_hsa047131.71534086
30RNA polymerase_Homo sapiens_hsa030201.71422713
31Fructose and mannose metabolism_Homo sapiens_hsa000511.68274457
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66502024
33RNA degradation_Homo sapiens_hsa030181.65121725
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65066236
35Non-homologous end-joining_Homo sapiens_hsa034501.59091217
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56669237
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52771539
38p53 signaling pathway_Homo sapiens_hsa041151.50767194
39Serotonergic synapse_Homo sapiens_hsa047261.49495589
40Long-term depression_Homo sapiens_hsa047301.47477356
41Butanoate metabolism_Homo sapiens_hsa006501.42733567
42Tryptophan metabolism_Homo sapiens_hsa003801.37580111
43Insulin secretion_Homo sapiens_hsa049111.36924775
44Pyrimidine metabolism_Homo sapiens_hsa002401.36666601
45Oocyte meiosis_Homo sapiens_hsa041141.35866902
46mTOR signaling pathway_Homo sapiens_hsa041501.35762277
47Cardiac muscle contraction_Homo sapiens_hsa042601.29174687
48Cocaine addiction_Homo sapiens_hsa050301.25548274
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21923249
50Calcium signaling pathway_Homo sapiens_hsa040201.21447810
51GABAergic synapse_Homo sapiens_hsa047271.20987213
52Ribosome_Homo sapiens_hsa030101.20559355
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17453928
54Ovarian steroidogenesis_Homo sapiens_hsa049131.15706802
55Dopaminergic synapse_Homo sapiens_hsa047281.15654664
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13931683
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13849112
58Thyroid cancer_Homo sapiens_hsa052161.09606787
59Viral carcinogenesis_Homo sapiens_hsa052031.08111605
60Central carbon metabolism in cancer_Homo sapiens_hsa052301.03825386
61Cholinergic synapse_Homo sapiens_hsa047251.03126709
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02105463
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.00730495
64Caffeine metabolism_Homo sapiens_hsa002321.00385520
65MicroRNAs in cancer_Homo sapiens_hsa052061.00082022
66Amphetamine addiction_Homo sapiens_hsa050310.99330661
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.97614000
68Basal cell carcinoma_Homo sapiens_hsa052170.96980079
69HTLV-I infection_Homo sapiens_hsa051660.96645248
70Galactose metabolism_Homo sapiens_hsa000520.95884136
71Epstein-Barr virus infection_Homo sapiens_hsa051690.94991346
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94317395
73Hippo signaling pathway_Homo sapiens_hsa043900.91684557
74Colorectal cancer_Homo sapiens_hsa052100.90910713
75Inositol phosphate metabolism_Homo sapiens_hsa005620.90775818
76Sulfur relay system_Homo sapiens_hsa041220.90513942
77Acute myeloid leukemia_Homo sapiens_hsa052210.89313932
78Herpes simplex infection_Homo sapiens_hsa051680.88966527
79Retinol metabolism_Homo sapiens_hsa008300.88143178
80Gastric acid secretion_Homo sapiens_hsa049710.87734462
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87280823
82Chemical carcinogenesis_Homo sapiens_hsa052040.86649871
83Hedgehog signaling pathway_Homo sapiens_hsa043400.86645008
84Notch signaling pathway_Homo sapiens_hsa043300.86017355
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83221039
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82799612
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81873857
88Proteasome_Homo sapiens_hsa030500.81725212
89Selenocompound metabolism_Homo sapiens_hsa004500.80910688
90ABC transporters_Homo sapiens_hsa020100.80829341
91Oxytocin signaling pathway_Homo sapiens_hsa049210.80305283
92Type II diabetes mellitus_Homo sapiens_hsa049300.78751598
93Pentose phosphate pathway_Homo sapiens_hsa000300.77334153
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.76456172
95Axon guidance_Homo sapiens_hsa043600.75014727
96Arachidonic acid metabolism_Homo sapiens_hsa005900.74197767
97Antigen processing and presentation_Homo sapiens_hsa046120.73812715
98Systemic lupus erythematosus_Homo sapiens_hsa053220.73382756
99MAPK signaling pathway_Homo sapiens_hsa040100.72877071
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72563938
101Pathways in cancer_Homo sapiens_hsa052000.71959840
102Oxidative phosphorylation_Homo sapiens_hsa001900.70642323
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70372509
104Non-small cell lung cancer_Homo sapiens_hsa052230.69976029
105Small cell lung cancer_Homo sapiens_hsa052220.69949263
106Purine metabolism_Homo sapiens_hsa002300.69067384
107Pancreatic secretion_Homo sapiens_hsa049720.67281623
108Chronic myeloid leukemia_Homo sapiens_hsa052200.67172153
109Histidine metabolism_Homo sapiens_hsa003400.67003642
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64283304
111Melanoma_Homo sapiens_hsa052180.63417078
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.61701933
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61238994
114cAMP signaling pathway_Homo sapiens_hsa040240.60111867
115Endometrial cancer_Homo sapiens_hsa052130.60022598
116Glycerolipid metabolism_Homo sapiens_hsa005610.59386938
117TGF-beta signaling pathway_Homo sapiens_hsa043500.58678819
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58610829
119VEGF signaling pathway_Homo sapiens_hsa043700.58456236
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58121694
121Apoptosis_Homo sapiens_hsa042100.57946173
122Salivary secretion_Homo sapiens_hsa049700.57816271
123Adherens junction_Homo sapiens_hsa045200.57805922
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57767335
125Huntingtons disease_Homo sapiens_hsa050160.57335245
126Pancreatic cancer_Homo sapiens_hsa052120.57310453
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57185346
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56888294
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55638196
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55176455
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55171913
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54183488
133Fat digestion and absorption_Homo sapiens_hsa049750.53171008
134Linoleic acid metabolism_Homo sapiens_hsa005910.53102577
135beta-Alanine metabolism_Homo sapiens_hsa004100.52782625
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.52703962
137Ras signaling pathway_Homo sapiens_hsa040140.51838631
138Peroxisome_Homo sapiens_hsa041460.50639521
139Thyroid hormone synthesis_Homo sapiens_hsa049180.48514353
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48168617
141B cell receptor signaling pathway_Homo sapiens_hsa046620.47959202
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47924861
143Parkinsons disease_Homo sapiens_hsa050120.47922575
144Protein export_Homo sapiens_hsa030600.47562841
145Biosynthesis of amino acids_Homo sapiens_hsa012300.47185236
146Wnt signaling pathway_Homo sapiens_hsa043100.47117809
147Starch and sucrose metabolism_Homo sapiens_hsa005000.47034408
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45818750
149Choline metabolism in cancer_Homo sapiens_hsa052310.45343513
150Alcoholism_Homo sapiens_hsa050340.44976416
151T cell receptor signaling pathway_Homo sapiens_hsa046600.44821546
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.44412060
153Bladder cancer_Homo sapiens_hsa052190.43809586
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43636320
155Alzheimers disease_Homo sapiens_hsa050100.42818783
156Proteoglycans in cancer_Homo sapiens_hsa052050.42767430
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.42466819
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42195981
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.41107094
160Tight junction_Homo sapiens_hsa045300.39282502
161Dorso-ventral axis formation_Homo sapiens_hsa043200.39133034
162Fatty acid biosynthesis_Homo sapiens_hsa000610.38638813
163Rap1 signaling pathway_Homo sapiens_hsa040150.38294989
164Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38257263
165Influenza A_Homo sapiens_hsa051640.37622509
166Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36774129
167Asthma_Homo sapiens_hsa053100.35882313
168Leukocyte transendothelial migration_Homo sapiens_hsa046700.35861276
169AMPK signaling pathway_Homo sapiens_hsa041520.35860526
170Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34778730
171Legionellosis_Homo sapiens_hsa051340.34690920
172Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33520045
173Shigellosis_Homo sapiens_hsa051310.33288707
174Glycerophospholipid metabolism_Homo sapiens_hsa005640.32780504
175Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32090921
176Hepatitis B_Homo sapiens_hsa051610.31757295
177Regulation of autophagy_Homo sapiens_hsa041400.31314007
178Primary immunodeficiency_Homo sapiens_hsa053400.31160783
179Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31101387
180HIF-1 signaling pathway_Homo sapiens_hsa040660.30955793
181Cysteine and methionine metabolism_Homo sapiens_hsa002700.28789120

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