KATNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)4.34647299
2mitotic metaphase plate congression (GO:0007080)4.14409883
3establishment of protein localization to mitochondrial membrane (GO:0090151)3.95071655
4DNA catabolic process, exonucleolytic (GO:0000738)3.91818826
5resolution of meiotic recombination intermediates (GO:0000712)3.83933913
6synapsis (GO:0007129)3.81502988
7DNA replication checkpoint (GO:0000076)3.77843546
8ribosomal small subunit assembly (GO:0000028)3.74877811
9purine nucleobase biosynthetic process (GO:0009113)3.71578671
10cullin deneddylation (GO:0010388)3.60009388
11DNA strand elongation involved in DNA replication (GO:0006271)3.58592967
12metaphase plate congression (GO:0051310)3.54235995
13nucleobase biosynthetic process (GO:0046112)3.53133618
14DNA replication initiation (GO:0006270)3.50086795
15protein deneddylation (GO:0000338)3.47550651
16DNA strand elongation (GO:0022616)3.45901170
17telomere maintenance via semi-conservative replication (GO:0032201)3.44997103
18telomere maintenance via recombination (GO:0000722)3.44104340
19mitotic sister chromatid segregation (GO:0000070)3.43662807
20CENP-A containing nucleosome assembly (GO:0034080)3.40904477
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.39242446
22chaperone-mediated protein transport (GO:0072321)3.37994723
23maturation of SSU-rRNA (GO:0030490)3.37008886
24formation of translation preinitiation complex (GO:0001731)3.36350800
25postreplication repair (GO:0006301)3.30158201
26chromatin remodeling at centromere (GO:0031055)3.28732360
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27093393
28sister chromatid segregation (GO:0000819)3.22990057
29pseudouridine synthesis (GO:0001522)3.22667728
30mitotic sister chromatid cohesion (GO:0007064)3.22451262
31ribosome biogenesis (GO:0042254)3.22373987
32DNA deamination (GO:0045006)3.20493255
33mitotic recombination (GO:0006312)3.20038907
34mitotic spindle checkpoint (GO:0071174)3.18406551
35translesion synthesis (GO:0019985)3.17779593
36regulation of chromosome segregation (GO:0051983)3.14814064
37establishment of chromosome localization (GO:0051303)3.14653289
38protein localization to kinetochore (GO:0034501)3.13617322
39positive regulation of ligase activity (GO:0051351)3.10868147
40mitochondrial DNA replication (GO:0006264)3.08448458
41DNA double-strand break processing (GO:0000729)3.08429358
42DNA replication-independent nucleosome assembly (GO:0006336)3.06775787
43DNA replication-independent nucleosome organization (GO:0034724)3.06775787
44DNA-dependent DNA replication (GO:0006261)3.06002225
45mitotic nuclear envelope disassembly (GO:0007077)3.03836929
46centriole replication (GO:0007099)3.03436766
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02663184
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02663184
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02663184
50negative regulation of mitotic sister chromatid separation (GO:2000816)3.02663184
51negative regulation of sister chromatid segregation (GO:0033046)3.02663184
52negative regulation of chromosome segregation (GO:0051985)3.02591857
53regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02485672
54regulation of ubiquitin-protein transferase activity (GO:0051438)3.00891294
55nuclear pore organization (GO:0006999)3.00548302
56DNA ligation (GO:0006266)2.98562598
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96190163
58regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96190163
59spliceosomal snRNP assembly (GO:0000387)2.94889805
60spindle assembly checkpoint (GO:0071173)2.94865871
61regulation of spindle organization (GO:0090224)2.94747141
62mitotic spindle assembly checkpoint (GO:0007094)2.94210430
63ribonucleoprotein complex biogenesis (GO:0022613)2.93874200
64attachment of spindle microtubules to kinetochore (GO:0008608)2.92692441
65male meiosis I (GO:0007141)2.92672374
66transcription from mitochondrial promoter (GO:0006390)2.92552716
67ribosome assembly (GO:0042255)2.92372246
68histone mRNA metabolic process (GO:0008334)2.90060725
69regulation of ligase activity (GO:0051340)2.90043018
70rRNA modification (GO:0000154)2.89431825
71kinetochore organization (GO:0051383)2.88100903
72proteasome assembly (GO:0043248)2.80327615
73ribosomal large subunit biogenesis (GO:0042273)2.79036754
74protein localization to chromosome, centromeric region (GO:0071459)2.78768987
75membrane disassembly (GO:0030397)2.78653767
76nuclear envelope disassembly (GO:0051081)2.78653767
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78094210
78protein K6-linked ubiquitination (GO:0085020)2.77583287
79meiotic chromosome segregation (GO:0045132)2.76812551
80telomere maintenance via telomere lengthening (GO:0010833)2.76095473
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75608676
82nuclear pore complex assembly (GO:0051292)2.75500050
83histone exchange (GO:0043486)2.75413979
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73734444
85kinetochore assembly (GO:0051382)2.72489130
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69112358
87regulation of helicase activity (GO:0051095)2.68953280
88DNA unwinding involved in DNA replication (GO:0006268)2.66587031
89transcription-coupled nucleotide-excision repair (GO:0006283)2.64296300
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61914517
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61626118
927-methylguanosine mRNA capping (GO:0006370)2.61249361
93IMP biosynthetic process (GO:0006188)2.61006671
94rRNA processing (GO:0006364)2.60200268
95cell cycle G1/S phase transition (GO:0044843)2.59686117
96G1/S transition of mitotic cell cycle (GO:0000082)2.59686117
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.59180929
987-methylguanosine RNA capping (GO:0009452)2.57994680
99RNA capping (GO:0036260)2.57994680
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.57659619
101termination of RNA polymerase III transcription (GO:0006386)2.57659619
102rRNA metabolic process (GO:0016072)2.56945573
103DNA replication-dependent nucleosome organization (GO:0034723)2.56917139
104DNA replication-dependent nucleosome assembly (GO:0006335)2.56917139
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.55373272
106mitotic chromosome condensation (GO:0007076)2.55139731
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52229481
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.51206710
109regulation of RIG-I signaling pathway (GO:0039535)2.50777276
110signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49971318
111signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49971318
112signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49971318
113translational termination (GO:0006415)2.49727881
114viral transcription (GO:0019083)2.49247816
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49137968
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49137968
117telomere maintenance (GO:0000723)2.48979011
118telomere organization (GO:0032200)2.48190847
119ribosomal small subunit biogenesis (GO:0042274)2.46636802
120viral mRNA export from host cell nucleus (GO:0046784)2.46536017
121regulation of mitotic spindle organization (GO:0060236)2.45626517
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.45190728
123rRNA methylation (GO:0031167)2.44949948
124positive regulation of chromosome segregation (GO:0051984)2.44265609
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.44028873
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.44028873
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.41226678
128NIK/NF-kappaB signaling (GO:0038061)2.41042647
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40241992
130negative regulation of ligase activity (GO:0051352)2.40241992
131translational initiation (GO:0006413)2.40029818
132termination of RNA polymerase I transcription (GO:0006363)2.39048954
133replication fork processing (GO:0031297)2.39034194
134spindle checkpoint (GO:0031577)2.38355042
135SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.38029656
136maturation of 5.8S rRNA (GO:0000460)2.37712620
137transcription elongation from RNA polymerase II promoter (GO:0006368)2.36199602
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35453548
139folic acid metabolic process (GO:0046655)2.35067281
140IMP metabolic process (GO:0046040)2.34515154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.04667537
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.31473781
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.21381969
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06780934
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02732141
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.00705093
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89806125
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.78824977
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75896276
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61666936
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50820633
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.47605851
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.40326574
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31589315
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31219262
16VDR_23849224_ChIP-Seq_CD4+_Human2.30464182
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29618955
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25546092
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.20817952
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.18242076
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17709150
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15931623
23* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14424613
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04781778
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97801039
26XRN2_22483619_ChIP-Seq_HELA_Human1.90959636
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88476383
28ELK1_19687146_ChIP-ChIP_HELA_Human1.84287395
29FOXP3_21729870_ChIP-Seq_TREG_Human1.83491198
30DCP1A_22483619_ChIP-Seq_HELA_Human1.83306052
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81508975
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79757989
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.78944730
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.77678943
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75314116
36AR_21909140_ChIP-Seq_LNCAP_Human1.74762974
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.73149017
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72237110
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68197514
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62856999
41GABP_19822575_ChIP-Seq_HepG2_Human1.62730855
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60815274
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59557958
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58244151
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57238333
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54222075
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.51835295
48* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49681687
49SPI1_23547873_ChIP-Seq_NB4_Human1.45784702
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44850045
51TTF2_22483619_ChIP-Seq_HELA_Human1.44817388
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44121795
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.42545290
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.42115913
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38269119
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36173993
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33320329
58CIITA_25753668_ChIP-Seq_RAJI_Human1.33020526
59TFEB_21752829_ChIP-Seq_HELA_Human1.32773995
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.32188860
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30566098
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30551629
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29388480
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29366857
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28933008
66KDM5A_27292631_Chip-Seq_BREAST_Human1.28719253
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28001398
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25641306
69ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23974641
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18754511
71MYC_22102868_ChIP-Seq_BL_Human1.15140177
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13021448
73GATA1_22025678_ChIP-Seq_K562_Human1.12833781
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12401457
75FUS_26573619_Chip-Seq_HEK293_Human1.11737531
76EWS_26573619_Chip-Seq_HEK293_Human1.11530498
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.10355614
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10131814
79MYB_26560356_Chip-Seq_TH2_Human1.10049733
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07854185
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07335186
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01675709
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01507207
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00989955
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99406925
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98301540
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96645308
88MYB_26560356_Chip-Seq_TH1_Human0.96536919
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.96433148
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94214463
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93767714
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93377251
93ZNF274_21170338_ChIP-Seq_K562_Hela0.93285438
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93255539
95* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93211951
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90636531
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90169901
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89279721
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.89041165
100IRF8_27001747_Chip-Seq_BMDM_Mouse0.88693668
101RUNX1_22412390_ChIP-Seq_EML_Mouse0.88134273
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87570568
103MYC_18940864_ChIP-ChIP_HL60_Human0.84894269
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84628375
105STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83109999
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82680810
107SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80718564
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79985064
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79675175
110BP1_19119308_ChIP-ChIP_Hs578T_Human0.79560690
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.79367308
112SALL4_22934838_ChIP-ChIP_CD34+_Human0.76158158
113IRF1_19129219_ChIP-ChIP_H3396_Human0.74275786
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.74093187
115VDR_22108803_ChIP-Seq_LS180_Human0.74062771
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.72756044
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.70816888
118IGF1R_20145208_ChIP-Seq_DFB_Human0.69977124
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.64587861
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.62789580
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61653151

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.30409619
2MP0010094_abnormal_chromosome_stability3.23299184
3MP0004957_abnormal_blastocyst_morpholog3.12800786
4MP0008057_abnormal_DNA_replication3.01751161
5MP0009697_abnormal_copulation3.00315738
6MP0003111_abnormal_nucleus_morphology2.96554725
7MP0003077_abnormal_cell_cycle2.94404292
8MP0001835_abnormal_antigen_presentation2.69347767
9MP0008058_abnormal_DNA_repair2.54167872
10MP0003950_abnormal_plasma_membrane2.44646314
11MP0008007_abnormal_cellular_replicative2.32752106
12MP0000372_irregular_coat_pigmentation2.27105403
13MP0003763_abnormal_thymus_physiology2.16324804
14MP0009785_altered_susceptibility_to2.15724208
15MP0005671_abnormal_response_to2.09683656
16MP0002396_abnormal_hematopoietic_system2.01673668
17MP0009333_abnormal_splenocyte_physiolog2.01163660
18MP0006035_abnormal_mitochondrial_morpho2.00115667
19MP0002102_abnormal_ear_morphology1.99884335
20MP0006036_abnormal_mitochondrial_physio1.98435338
21MP0000685_abnormal_immune_system1.97137785
22MP0001929_abnormal_gametogenesis1.84631216
23MP0010307_abnormal_tumor_latency1.81351064
24MP0003436_decreased_susceptibility_to1.79050135
25MP0001800_abnormal_humoral_immune1.76738095
26MP0005000_abnormal_immune_tolerance1.69725494
27MP0010352_gastrointestinal_tract_polyps1.69681203
28MP0002452_abnormal_antigen_presenting1.67096468
29MP0002398_abnormal_bone_marrow1.66549086
30MP0008932_abnormal_embryonic_tissue1.63127673
31MP0003646_muscle_fatigue1.62455459
32MP0002148_abnormal_hypersensitivity_rea1.62079915
33MP0005025_abnormal_response_to1.61391948
34MP0002723_abnormal_immune_serum1.60142752
35MP0000490_abnormal_crypts_of1.58715156
36MP0001819_abnormal_immune_cell1.57510480
37MP0002420_abnormal_adaptive_immunity1.56439669
38MP0003786_premature_aging1.54415190
39MP0005410_abnormal_fertilization1.53575721
40MP0002405_respiratory_system_inflammati1.52336375
41MP0001853_heart_inflammation1.50322662
42MP0002006_tumorigenesis1.49706249
43MP0000350_abnormal_cell_proliferation1.48347940
44MP0005387_immune_system_phenotype1.47624405
45MP0001790_abnormal_immune_system1.47624405
46MP0001545_abnormal_hematopoietic_system1.47117212
47MP0005397_hematopoietic_system_phenotyp1.47117212
48MP0002095_abnormal_skin_pigmentation1.46141959
49MP0000689_abnormal_spleen_morphology1.44384062
50MP0002722_abnormal_immune_system1.43714867
51MP0000716_abnormal_immune_system1.42836687
52MP0003718_maternal_effect1.41342303
53MP0001730_embryonic_growth_arrest1.40406568
54MP0002419_abnormal_innate_immunity1.38931114
55MP0004808_abnormal_hematopoietic_stem1.37823986
56MP0003806_abnormal_nucleotide_metabolis1.36545108
57MP0002019_abnormal_tumor_incidence1.36503097
58MP0003724_increased_susceptibility_to1.35797045
59MP0002166_altered_tumor_susceptibility1.34041682
60MP0002429_abnormal_blood_cell1.33850567
61MP0000653_abnormal_sex_gland1.33680222
62MP0010155_abnormal_intestine_physiology1.28887140
63MP0000858_altered_metastatic_potential1.27540222
64MP0000703_abnormal_thymus_morphology1.26592116
65MP0003941_abnormal_skin_development1.24313705
66MP0003186_abnormal_redox_activity1.24158037
67MP0001293_anophthalmia1.22353737
68MP0000015_abnormal_ear_pigmentation1.21782603
69MP0006082_CNS_inflammation1.19543448
70MP0001764_abnormal_homeostasis1.19011978
71MP0005084_abnormal_gallbladder_morpholo1.17264149
72MP0008877_abnormal_DNA_methylation1.17077058
73MP0001845_abnormal_inflammatory_respons1.15786860
74MP0000313_abnormal_cell_death1.13732743
75MP0003448_altered_tumor_morphology1.09315029
76MP0003698_abnormal_male_reproductive1.09305909
77MP0004947_skin_inflammation1.05723438
78MP0001697_abnormal_embryo_size1.00424064
79MP0002132_abnormal_respiratory_system1.00065813
80MP0001672_abnormal_embryogenesis/_devel0.98560722
81MP0005380_embryogenesis_phenotype0.98560722
82MP0002139_abnormal_hepatobiliary_system0.96014420
83MP0004147_increased_porphyrin_level0.94352587
84MP0003123_paternal_imprinting0.94281323
85MP0005464_abnormal_platelet_physiology0.94096789
86MP0005174_abnormal_tail_pigmentation0.93081444
87MP0005395_other_phenotype0.92839614
88MP0002277_abnormal_respiratory_mucosa0.91050109
89MP0002080_prenatal_lethality0.90514339
90MP0008469_abnormal_protein_level0.88623236
91MP0001119_abnormal_female_reproductive0.87726331
92MP0005023_abnormal_wound_healing0.87127302
93MP0002210_abnormal_sex_determination0.86401665
94MP0003221_abnormal_cardiomyocyte_apopto0.85435317
95MP0001188_hyperpigmentation0.85265255
96MP0003567_abnormal_fetal_cardiomyocyte0.85264341
97MP0003984_embryonic_growth_retardation0.85153526
98MP0002088_abnormal_embryonic_growth/wei0.83340607
99MP0000371_diluted_coat_color0.82611977
100MP0001324_abnormal_eye_pigmentation0.82068292
101MP0002086_abnormal_extraembryonic_tissu0.80461554
102MP0002009_preneoplasia0.80005691
103MP0008873_increased_physiological_sensi0.79651497
104MP0001533_abnormal_skeleton_physiology0.79312764
105MP0008789_abnormal_olfactory_epithelium0.78827145
106MP0002234_abnormal_pharynx_morphology0.78651222
107MP0005075_abnormal_melanosome_morpholog0.78590612
108MP0005408_hypopigmentation0.78162033
109MP0002877_abnormal_melanocyte_morpholog0.77592210
110MP0004782_abnormal_surfactant_physiolog0.77488735
111MP0003890_abnormal_embryonic-extraembry0.76329547
112MP0002138_abnormal_hepatobiliary_system0.74863669
113MP0006292_abnormal_olfactory_placode0.74612533
114MP0003699_abnormal_female_reproductive0.74011529
115MP0005310_abnormal_salivary_gland0.73412076
116MP0005389_reproductive_system_phenotype0.73182437
117MP0002161_abnormal_fertility/fecundity0.72870966
118MP0001873_stomach_inflammation0.72830771
119MP0005171_absent_coat_pigmentation0.72791327
120MP0002163_abnormal_gland_morphology0.72344584
121MP0005384_cellular_phenotype0.72230393
122MP0000465_gastrointestinal_hemorrhage0.71746490
123MP0005076_abnormal_cell_differentiation0.71691721
124MP0006072_abnormal_retinal_apoptosis0.71059677
125MP0001243_abnormal_dermal_layer0.70644688
126MP0000358_abnormal_cell_content/0.70465248
127MP0002084_abnormal_developmental_patter0.69664489
128MP0003566_abnormal_cell_adhesion0.68614982
129MP0000647_abnormal_sebaceous_gland0.68558105
130MP0001145_abnormal_male_reproductive0.67987391
131MP0003937_abnormal_limbs/digits/tail_de0.67951303
132MP0003453_abnormal_keratinocyte_physiol0.67916773
133MP0001216_abnormal_epidermal_layer0.67612698
134MP0002085_abnormal_embryonic_tissue0.66965408
135MP0008995_early_reproductive_senescence0.66195766
136MP0003121_genomic_imprinting0.65370573
137MP0006054_spinal_hemorrhage0.64640820
138MP0005451_abnormal_body_composition0.64323027
139MP0003936_abnormal_reproductive_system0.64280980
140MP0002933_joint_inflammation0.64195996
141MP0002938_white_spotting0.63804989
142MP0008260_abnormal_autophagy0.63618365
143MP0002282_abnormal_trachea_morphology0.61263820
144MP0001186_pigmentation_phenotype0.60524642
145MP0001191_abnormal_skin_condition0.59122038
146MP0001661_extended_life_span0.58339122
147MP0001529_abnormal_vocalization0.57486436
148MP0003136_yellow_coat_color0.56698408
149MP0002160_abnormal_reproductive_system0.56640149
150MP0001881_abnormal_mammary_gland0.54784097
151MP0000678_abnormal_parathyroid_gland0.54689347
152MP0005501_abnormal_skin_physiology0.54376048
153MP0001286_abnormal_eye_development0.53690956
154MP0000569_abnormal_digit_pigmentation0.52879749

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.83889955
2Acute necrotizing encephalopathy (HP:0006965)3.97133211
3Acute encephalopathy (HP:0006846)3.72165114
4Abnormal mitochondria in muscle tissue (HP:0008316)3.60606637
5Increased CSF lactate (HP:0002490)3.47571288
6Recurrent abscess formation (HP:0002722)3.37526836
7Breast hypoplasia (HP:0003187)3.35167224
8Mitochondrial inheritance (HP:0001427)3.32665090
9Chromsome breakage (HP:0040012)3.20079379
10Reticulocytopenia (HP:0001896)3.18242949
11Increased serum pyruvate (HP:0003542)3.16257583
12Progressive macrocephaly (HP:0004481)3.15067358
13Recurrent bacterial skin infections (HP:0005406)3.10935469
14Thrombocytosis (HP:0001894)3.08806833
15Eczematoid dermatitis (HP:0000976)3.06834091
16Aplastic anemia (HP:0001915)3.05992042
17Increased hepatocellular lipid droplets (HP:0006565)3.03594590
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.00104660
19Lipid accumulation in hepatocytes (HP:0006561)2.96268050
20Hepatocellular necrosis (HP:0001404)2.90689089
21Hepatic necrosis (HP:0002605)2.80369218
22Abnormality of glycolysis (HP:0004366)2.75968103
23Increased serum lactate (HP:0002151)2.75829892
24Degeneration of anterior horn cells (HP:0002398)2.71439564
25Abnormality of the anterior horn cell (HP:0006802)2.71439564
26Cerebral edema (HP:0002181)2.67483045
27Abnormality of cells of the erythroid lineage (HP:0012130)2.61011452
28Oral leukoplakia (HP:0002745)2.60296330
29Abnormality of the preputium (HP:0100587)2.59516061
30Abnormality of chromosome stability (HP:0003220)2.59450393
31Patellar aplasia (HP:0006443)2.57924038
32Pustule (HP:0200039)2.54702053
33Abnormal number of erythroid precursors (HP:0012131)2.54641841
34Elevated erythrocyte sedimentation rate (HP:0003565)2.54589122
35Myelodysplasia (HP:0002863)2.53904228
36Sloping forehead (HP:0000340)2.53672743
37Petechiae (HP:0000967)2.52613650
38Abnormality of T cell number (HP:0011839)2.51973271
39IgM deficiency (HP:0002850)2.51232861
40Volvulus (HP:0002580)2.48128156
41Aplasia/Hypoplasia of the patella (HP:0006498)2.47526849
42Carpal bone hypoplasia (HP:0001498)2.46629751
43Renal Fanconi syndrome (HP:0001994)2.46407693
44T lymphocytopenia (HP:0005403)2.45592281
45Microvesicular hepatic steatosis (HP:0001414)2.42370008
46Abnormal lung lobation (HP:0002101)2.39773881
47Autoimmune thrombocytopenia (HP:0001973)2.38829666
48Methylmalonic acidemia (HP:0002912)2.38641562
49Meckel diverticulum (HP:0002245)2.37499722
50Lactic acidosis (HP:0003128)2.34907477
51IgG deficiency (HP:0004315)2.34195803
52Myositis (HP:0100614)2.32565506
53Agnosia (HP:0010524)2.31590778
54Abnormality of the labia minora (HP:0012880)2.31486815
55Abnormality of T cells (HP:0002843)2.30969870
56Cleft eyelid (HP:0000625)2.30316406
57Rough bone trabeculation (HP:0100670)2.30228347
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30135016
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30135016
60Lymphoma (HP:0002665)2.29306918
61Combined immunodeficiency (HP:0005387)2.29290821
62Type I transferrin isoform profile (HP:0003642)2.26573998
63Recurrent fungal infections (HP:0002841)2.25879854
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24715329
65Microretrognathia (HP:0000308)2.24192415
66Amaurosis fugax (HP:0100576)2.22793020
67Abnormality of the ileum (HP:0001549)2.22775917
68Premature ovarian failure (HP:0008209)2.21615948
69Recurrent viral infections (HP:0004429)2.21608060
70Bone marrow hypocellularity (HP:0005528)2.21262581
71Respiratory failure (HP:0002878)2.20386709
72Hyperglycinemia (HP:0002154)2.20329487
73Abnormality of the duodenum (HP:0002246)2.19167257
74Abnormal spermatogenesis (HP:0008669)2.18805425
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16530542
76Exercise intolerance (HP:0003546)2.16400994
77Horseshoe kidney (HP:0000085)2.16393453
78Megaloblastic anemia (HP:0001889)2.16193202
79Mediastinal lymphadenopathy (HP:0100721)2.15845374
80Abnormality of methionine metabolism (HP:0010901)2.14353804
81Reduced antithrombin III activity (HP:0001976)2.13269554
82Selective tooth agenesis (HP:0001592)2.13248809
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.11557725
84Granulocytopenia (HP:0001913)2.11294368
85Severe combined immunodeficiency (HP:0004430)2.11004346
86Multiple enchondromatosis (HP:0005701)2.10476053
87Pallor (HP:0000980)2.09371700
88Respiratory difficulties (HP:0002880)2.08445117
89Eosinophilia (HP:0001880)2.07058439
90Colon cancer (HP:0003003)2.06756431
9111 pairs of ribs (HP:0000878)2.05183303
92Abnormality of eosinophils (HP:0001879)2.04370733
93Optic disc pallor (HP:0000543)2.04279600
94Abnormality of T cell physiology (HP:0011840)2.03101039
95Limb hypertonia (HP:0002509)2.02358236
96Leukocytosis (HP:0001974)2.02035037
97Abnormality of the fovea (HP:0000493)2.01725439
98Premature graying of hair (HP:0002216)2.01608601
99Poor head control (HP:0002421)2.00763007
100Abnormality of DNA repair (HP:0003254)2.00176971
101Neoplasm of the colon (HP:0100273)1.98042714
102Absent thumb (HP:0009777)1.97416898
103Methylmalonic aciduria (HP:0012120)1.97404902
1043-Methylglutaconic aciduria (HP:0003535)1.95397761
105Triphalangeal thumb (HP:0001199)1.95347427
106Chronic obstructive pulmonary disease (HP:0006510)1.94964469
107Obstructive lung disease (HP:0006536)1.94964469
108IgA deficiency (HP:0002720)1.93231289
109Abnormality of macrophages (HP:0004311)1.93136176
110Recurrent skin infections (HP:0001581)1.91773414
111Chronic otitis media (HP:0000389)1.91752352
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.90897214
113Acute myeloid leukemia (HP:0004808)1.90367604
114Recurrent bronchitis (HP:0002837)1.89954746
115Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88210361
116Secondary amenorrhea (HP:0000869)1.86743811
117Lethargy (HP:0001254)1.86459305
118CNS demyelination (HP:0007305)1.86384827
119Generalized aminoaciduria (HP:0002909)1.86024150
120Clubbing of toes (HP:0100760)1.85920542
121Recurrent pneumonia (HP:0006532)1.85398442
122Macrocytic anemia (HP:0001972)1.85389302
123Optic neuritis (HP:0100653)1.84630223
124Retrobulbar optic neuritis (HP:0100654)1.84630223
125Cellular immunodeficiency (HP:0005374)1.84586926
126Nausea (HP:0002018)1.84023351
127Pancytopenia (HP:0001876)1.82618944
128Neoplasm of the pancreas (HP:0002894)1.81861352
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80997433
130Azoospermia (HP:0000027)1.80658487
131Increased intramyocellular lipid droplets (HP:0012240)1.80415435
132Abnormal protein glycosylation (HP:0012346)1.79830151
133Abnormal glycosylation (HP:0012345)1.79830151
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79830151
135Abnormal protein N-linked glycosylation (HP:0012347)1.79830151
136Abnormal trabecular bone morphology (HP:0100671)1.79564296
137Cerebral hypomyelination (HP:0006808)1.79046834
138Ectopic kidney (HP:0000086)1.78807772
139Cutaneous melanoma (HP:0012056)1.78387490
140B lymphocytopenia (HP:0010976)1.77797340
141Recurrent gram-negative bacterial infections (HP:0005420)1.76661252
142Small intestinal stenosis (HP:0012848)1.75301471
143Duodenal stenosis (HP:0100867)1.75301471
144Orchitis (HP:0100796)1.75155062
145Abnormality of serum amino acid levels (HP:0003112)1.74782605
146Chronic mucocutaneous candidiasis (HP:0002728)1.73880207
147Recurrent cutaneous fungal infections (HP:0011370)1.73880207
148Postnatal microcephaly (HP:0005484)1.73676368
149Pancreatic cysts (HP:0001737)1.72898839
150Postaxial foot polydactyly (HP:0001830)1.72749257
151Vasculitis (HP:0002633)1.72426379
152Tracheoesophageal fistula (HP:0002575)1.71466314
153Leukodystrophy (HP:0002415)1.71006185
154Trismus (HP:0000211)1.70856159
155Increased IgM level (HP:0003496)1.70373688
156Entropion (HP:0000621)1.69880060
157Abnormality of renal resorption (HP:0011038)1.69257915
158Sparse eyelashes (HP:0000653)1.68822258
159Abnormality of cells of the lymphoid lineage (HP:0012140)1.68533998
160Absent radius (HP:0003974)1.68031088
161Leukopenia (HP:0001882)1.67293159
162Prolonged neonatal jaundice (HP:0006579)1.67006294
163Sensory axonal neuropathy (HP:0003390)1.66889085
164Exertional dyspnea (HP:0002875)1.65635641
165Slender long bone (HP:0003100)1.65329045
166Rhabdomyosarcoma (HP:0002859)1.64858560
167Hypoplasia of the fovea (HP:0007750)1.64855450
168Aplasia/Hypoplasia of the fovea (HP:0008060)1.64855450
169Oligodactyly (hands) (HP:0001180)1.62381905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.30299321
2MAP3K123.07951465
3WEE13.06823501
4EIF2AK12.84700837
5ACVR1B2.69333766
6CDC72.44977573
7TRIM282.42153597
8PLK42.32808326
9NME22.31527793
10TYK22.22836742
11BRSK22.22623245
12EIF2AK32.20851274
13NEK22.12347286
14SRPK12.11358562
15IRAK42.02225382
16MAP4K12.01122975
17TXK1.97389905
18RPS6KA41.96068735
19IRAK31.93414997
20PNCK1.73150827
21VRK11.64929645
22ZAK1.63701914
23PBK1.57248171
24JAK31.55467196
25VRK21.51054025
26STK101.48823741
27NLK1.48374544
28STK161.46904148
29PLK11.46056409
30PDK21.42381083
31TTK1.42111617
32FLT31.41908187
33PIM21.41464675
34MST41.38308868
35IKBKB1.37670028
36ZAP701.35292173
37DYRK31.35016641
38IKBKE1.34007000
39MAP3K141.31816406
40TSSK61.30862501
41AURKB1.29915571
42ATR1.24036619
43CDK71.19932965
44BMPR1B1.18677385
45PIM11.17959769
46BCKDK1.16075521
47NEK11.14750149
48RPS6KB21.14548823
49PLK31.10930320
50TEC1.09662730
51TBK11.08950168
52MKNK11.07375234
53PASK1.06742135
54BRSK11.04559973
55STK41.02928969
56TGFBR11.02898258
57EIF2AK21.02664962
58CDK120.99020268
59MARK30.96416185
60SCYL20.92425533
61CDK40.91827305
62WNK30.91387292
63MAP3K80.91256065
64TAF10.90666401
65KIT0.90501638
66MAP3K30.89675700
67CHEK20.88111679
68EPHA20.88047405
69CHUK0.87794070
70PLK20.87535922
71ARAF0.87318423
72CSNK1G10.85239400
73KDR0.84364974
74TESK20.84241845
75TLK10.80169722
76STK30.79205003
77NUAK10.78836526
78MAPKAPK30.77518484
79BTK0.75513898
80BLK0.75268111
81DAPK10.75229299
82RAF10.73786266
83BMPR20.73497136
84CHEK10.72467566
85MELK0.71159978
86CSK0.70328604
87JAK10.70071463
88ERBB30.69090522
89STK38L0.69030711
90CSNK1G30.68505488
91NEK90.65952966
92CCNB10.65511722
93MKNK20.63486011
94BRAF0.62623992
95CSNK2A20.61879215
96PRKCI0.60876293
97CDK80.60770708
98AURKA0.58965329
99MAP2K30.58294487
100LYN0.57702036
101LRRK20.57605975
102NME10.56776258
103TRPM70.56704698
104CSNK2A10.55487280
105ATM0.55137236
106ITK0.53618099
107LCK0.53294134
108MAP3K50.53183482
109SYK0.52864451
110CSF1R0.51682269
111CSNK1G20.50662156
112RPS6KA50.50312081
113CSNK1A1L0.49593881
114MAPK110.47870808
115MOS0.47280353
116STK240.46979635
117TAOK20.46860040
118FGFR40.45817368
119AKT20.45217482
120MAP3K110.44642560
121BCR0.44275441
122MAP4K20.44029225
123CDK20.43759745
124MAP3K130.42299832
125MAPKAPK20.40343364
126CDK190.39847692
127ABL20.38497003
128CLK10.38391826
129PAK10.38125758
130CDK10.37292529
131MAP3K90.36596981
132IRAK10.36335997
133KSR10.36333548
134MAPK130.34997833
135NEK60.32208571
136YES10.31346961
137GRK70.30392178
138ERBB40.29892555
139TNIK0.27040415
140PRKCQ0.25660712
141MATK0.24468230

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80717086
2Mismatch repair_Homo sapiens_hsa034303.15216117
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14929008
4Proteasome_Homo sapiens_hsa030503.14727542
5RNA polymerase_Homo sapiens_hsa030203.08475077
6Ribosome_Homo sapiens_hsa030102.63048429
7Homologous recombination_Homo sapiens_hsa034402.53121503
8Spliceosome_Homo sapiens_hsa030402.43073874
9Base excision repair_Homo sapiens_hsa034102.42970382
10RNA transport_Homo sapiens_hsa030132.32795922
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27389048
12Nucleotide excision repair_Homo sapiens_hsa034202.22826423
13Cell cycle_Homo sapiens_hsa041102.20307133
14Oxidative phosphorylation_Homo sapiens_hsa001902.14722368
15Pyrimidine metabolism_Homo sapiens_hsa002402.11764808
16Basal transcription factors_Homo sapiens_hsa030222.01284384
17Parkinsons disease_Homo sapiens_hsa050121.88616222
18Fanconi anemia pathway_Homo sapiens_hsa034601.78880890
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75765640
20One carbon pool by folate_Homo sapiens_hsa006701.74127584
21p53 signaling pathway_Homo sapiens_hsa041151.71440357
22RNA degradation_Homo sapiens_hsa030181.69933817
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65183608
24Herpes simplex infection_Homo sapiens_hsa051681.64599333
25Steroid biosynthesis_Homo sapiens_hsa001001.62487826
26Non-homologous end-joining_Homo sapiens_hsa034501.62431075
27Propanoate metabolism_Homo sapiens_hsa006401.60709043
28Fatty acid elongation_Homo sapiens_hsa000621.56370819
29Primary immunodeficiency_Homo sapiens_hsa053401.54790342
30Huntingtons disease_Homo sapiens_hsa050161.50886262
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.48872838
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44341055
33Antigen processing and presentation_Homo sapiens_hsa046121.44173084
34Protein export_Homo sapiens_hsa030601.42395633
35Measles_Homo sapiens_hsa051621.42368054
36Legionellosis_Homo sapiens_hsa051341.39806752
37Allograft rejection_Homo sapiens_hsa053301.37604136
38Epstein-Barr virus infection_Homo sapiens_hsa051691.34635942
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.31069203
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15197979
41Leishmaniasis_Homo sapiens_hsa051401.15011398
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14057926
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13910177
44Folate biosynthesis_Homo sapiens_hsa007901.13791421
45Graft-versus-host disease_Homo sapiens_hsa053321.13136653
46Purine metabolism_Homo sapiens_hsa002301.07503925
47Influenza A_Homo sapiens_hsa051641.04248117
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03353165
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00186241
50Oocyte meiosis_Homo sapiens_hsa041140.96253763
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95717076
52mRNA surveillance pathway_Homo sapiens_hsa030150.95219920
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94418925
54Alzheimers disease_Homo sapiens_hsa050100.94350620
55Pyruvate metabolism_Homo sapiens_hsa006200.91502172
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90080799
57Hematopoietic cell lineage_Homo sapiens_hsa046400.88501156
58Apoptosis_Homo sapiens_hsa042100.87571756
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87493826
60Viral carcinogenesis_Homo sapiens_hsa052030.87105321
61Pentose phosphate pathway_Homo sapiens_hsa000300.83723892
62Asthma_Homo sapiens_hsa053100.82679834
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80539364
64Sulfur metabolism_Homo sapiens_hsa009200.79097074
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.78519212
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.76224365
67Hepatitis B_Homo sapiens_hsa051610.72152736
68HTLV-I infection_Homo sapiens_hsa051660.71648082
69Vitamin B6 metabolism_Homo sapiens_hsa007500.71609109
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70922092
71Selenocompound metabolism_Homo sapiens_hsa004500.70199989
72Sulfur relay system_Homo sapiens_hsa041220.70052551
73Systemic lupus erythematosus_Homo sapiens_hsa053220.69930567
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68470361
75Other glycan degradation_Homo sapiens_hsa005110.65962944
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64373593
77Autoimmune thyroid disease_Homo sapiens_hsa053200.64192831
78Type I diabetes mellitus_Homo sapiens_hsa049400.63256585
79Carbon metabolism_Homo sapiens_hsa012000.60670897
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59229187
81Shigellosis_Homo sapiens_hsa051310.59066194
82Toxoplasmosis_Homo sapiens_hsa051450.58355963
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57775045
84Metabolic pathways_Homo sapiens_hsa011000.56911750
85Malaria_Homo sapiens_hsa051440.56268858
86TNF signaling pathway_Homo sapiens_hsa046680.55128166
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53269572
88Osteoclast differentiation_Homo sapiens_hsa043800.53257098
89Small cell lung cancer_Homo sapiens_hsa052220.53013462
90Thyroid cancer_Homo sapiens_hsa052160.51203416
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.50338851
92T cell receptor signaling pathway_Homo sapiens_hsa046600.49374063
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49306756
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48863150
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48669361
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48499119
97Fatty acid metabolism_Homo sapiens_hsa012120.48177808
98Pertussis_Homo sapiens_hsa051330.47122753
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46749591
100Glutathione metabolism_Homo sapiens_hsa004800.46511306
101Tuberculosis_Homo sapiens_hsa051520.46279085
102Arachidonic acid metabolism_Homo sapiens_hsa005900.44050012
103B cell receptor signaling pathway_Homo sapiens_hsa046620.41780147
104Viral myocarditis_Homo sapiens_hsa054160.40755607
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37688071
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37335986
107Hepatitis C_Homo sapiens_hsa051600.34696264
108MicroRNAs in cancer_Homo sapiens_hsa052060.34694476
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34197086
110Butanoate metabolism_Homo sapiens_hsa006500.33991624
111Acute myeloid leukemia_Homo sapiens_hsa052210.32720265
112Biosynthesis of amino acids_Homo sapiens_hsa012300.31732231
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.31244876
114Rheumatoid arthritis_Homo sapiens_hsa053230.30841421
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30802124
116N-Glycan biosynthesis_Homo sapiens_hsa005100.30729093
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30428856
118Phototransduction_Homo sapiens_hsa047440.30335954
119TGF-beta signaling pathway_Homo sapiens_hsa043500.29631323
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29613968
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27875473
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.27235331
123Lysosome_Homo sapiens_hsa041420.25548301
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25394337
125Staphylococcus aureus infection_Homo sapiens_hsa051500.25341306
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.25331203
127Fructose and mannose metabolism_Homo sapiens_hsa000510.25068008
128Regulation of autophagy_Homo sapiens_hsa041400.23709671
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22280009
130Galactose metabolism_Homo sapiens_hsa000520.21785231
131Fatty acid degradation_Homo sapiens_hsa000710.20720802
132Collecting duct acid secretion_Homo sapiens_hsa049660.20313753
133Caffeine metabolism_Homo sapiens_hsa002320.20017619
134Peroxisome_Homo sapiens_hsa041460.18338252
135Cardiac muscle contraction_Homo sapiens_hsa042600.16009635
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14369863
137Tryptophan metabolism_Homo sapiens_hsa003800.06925473
138Lysine degradation_Homo sapiens_hsa003100.03268165
139Fatty acid biosynthesis_Homo sapiens_hsa000610.03195676
140Melanoma_Homo sapiens_hsa052180.02112699

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