KATNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.85365334
2sperm-egg recognition (GO:0035036)5.61197903
3binding of sperm to zona pellucida (GO:0007339)5.54487207
4fusion of sperm to egg plasma membrane (GO:0007342)5.37395003
5acrosome reaction (GO:0007340)5.29256353
6regulation of cilium movement (GO:0003352)5.06241571
7cell wall macromolecule catabolic process (GO:0016998)5.03313032
8cell wall macromolecule metabolic process (GO:0044036)5.03313032
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.01632488
10axonemal dynein complex assembly (GO:0070286)4.97945034
11cell-cell recognition (GO:0009988)4.97939858
12acrosome assembly (GO:0001675)4.92097778
13cilium or flagellum-dependent cell motility (GO:0001539)4.83254252
14motile cilium assembly (GO:0044458)4.82844758
15epithelial cilium movement (GO:0003351)4.80481627
16spermatid development (GO:0007286)4.75006150
17microtubule depolymerization (GO:0007019)4.52164924
18protein maturation by protein folding (GO:0022417)4.33430754
19proline biosynthetic process (GO:0006561)4.24416412
20multicellular organism reproduction (GO:0032504)4.20676740
21plasma membrane fusion (GO:0045026)4.19246232
22cilium movement (GO:0003341)4.13532024
23piRNA metabolic process (GO:0034587)4.03046261
24synaptonemal complex organization (GO:0070193)4.01207692
25synaptonemal complex assembly (GO:0007130)3.92124182
26telomere maintenance via semi-conservative replication (GO:0032201)3.91213099
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87116198
28regulation of mammary gland epithelial cell proliferation (GO:0033599)3.85860469
29heterochromatin organization (GO:0070828)3.82404206
30male meiosis (GO:0007140)3.82005504
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74782700
32pentose-phosphate shunt (GO:0006098)3.68051757
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66399261
34regulation of translational fidelity (GO:0006450)3.66025391
35peptidyl-arginine omega-N-methylation (GO:0035247)3.61591160
36reproduction (GO:0000003)3.52910896
37pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.49474544
38deoxyribose phosphate biosynthetic process (GO:0046385)3.47586719
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.47586719
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.43818092
41single strand break repair (GO:0000012)3.43667656
42pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.43320220
43nucleobase-containing small molecule interconversion (GO:0015949)3.40729329
44chromosome condensation (GO:0030261)3.40119789
45iron-sulfur cluster assembly (GO:0016226)3.38645947
46metallo-sulfur cluster assembly (GO:0031163)3.38645947
47NADPH regeneration (GO:0006740)3.34314651
48histone arginine methylation (GO:0034969)3.33193686
49negative regulation of inclusion body assembly (GO:0090084)3.31649876
50pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31375598
51regulation of microtubule-based movement (GO:0060632)3.30458670
52single fertilization (GO:0007338)3.25681904
53regulation of inclusion body assembly (GO:0090083)3.25159495
54IMP biosynthetic process (GO:0006188)3.24311598
55pyrimidine nucleotide catabolic process (GO:0006244)3.23466428
56DNA packaging (GO:0006323)3.23068308
57mitochondrial fusion (GO:0008053)3.22962575
58chaperone-mediated protein complex assembly (GO:0051131)3.22092773
59pentose metabolic process (GO:0019321)3.21870871
60rRNA transcription (GO:0009303)3.21087184
61spermatogenesis (GO:0007283)3.19687425
62male gamete generation (GO:0048232)3.18889221
63calcium ion-dependent exocytosis (GO:0017156)3.16269737
64histone H2A acetylation (GO:0043968)3.15732958
65peptidyl-arginine N-methylation (GO:0035246)3.14049131
66peptidyl-arginine methylation (GO:0018216)3.14049131
67spliceosomal tri-snRNP complex assembly (GO:0000244)3.13197224
68regulation of mitochondrial translation (GO:0070129)3.11987606
69pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.11390876
70glucose catabolic process (GO:0006007)3.11228327
71CTP biosynthetic process (GO:0006241)3.11098429
72CTP metabolic process (GO:0046036)3.11098429
73DNA replication-dependent nucleosome organization (GO:0034723)3.10559890
74DNA replication-dependent nucleosome assembly (GO:0006335)3.10559890
75base-excision repair (GO:0006284)3.10147467
76ventricular system development (GO:0021591)3.10101283
77DNA unwinding involved in DNA replication (GO:0006268)3.08504051
78telomere maintenance via recombination (GO:0000722)3.05369836
79Golgi transport vesicle coating (GO:0048200)3.04421734
80COPI coating of Golgi vesicle (GO:0048205)3.04421734
81mitotic nuclear envelope reassembly (GO:0007084)3.03245680
82nuclear envelope reassembly (GO:0031468)3.03245680
83ribosomal small subunit biogenesis (GO:0042274)3.02030085
84negative regulation of microtubule polymerization (GO:0031115)3.02016890
85mitotic sister chromatid segregation (GO:0000070)3.01634009
86DNA replication checkpoint (GO:0000076)3.01040102
87L-serine metabolic process (GO:0006563)3.00819275
88protein polyglutamylation (GO:0018095)2.98820339
89protein localization to chromosome, centromeric region (GO:0071459)2.96454762
90protein complex localization (GO:0031503)2.96013932
91meiotic nuclear division (GO:0007126)2.94119146
92positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.93799668
93UTP metabolic process (GO:0046051)2.93614926
94chromatin assembly (GO:0031497)2.93147083
95gamete generation (GO:0007276)2.92853925
96deoxyribonucleotide biosynthetic process (GO:0009263)2.92258121
97negative regulation of mRNA processing (GO:0050686)2.91963770
98sperm capacitation (GO:0048240)2.90934731
99fertilization (GO:0009566)2.90905613
100establishment of mitochondrion localization (GO:0051654)2.88774452
101mitotic chromosome condensation (GO:0007076)2.88148279
102chromosome organization involved in meiosis (GO:0070192)2.87967821
103proline metabolic process (GO:0006560)2.87234633
104mitochondrion transport along microtubule (GO:0047497)2.85413155
105establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85413155
106synaptic vesicle exocytosis (GO:0016079)2.85398019
107establishment of viral latency (GO:0019043)2.85240544
108deoxyribonucleotide catabolic process (GO:0009264)2.85192187
109GDP-mannose metabolic process (GO:0019673)2.84515523
110UV protection (GO:0009650)2.81829724
111peptidyl-arginine modification (GO:0018195)2.81265928
112dosage compensation (GO:0007549)2.80684905
113DNA strand elongation involved in DNA replication (GO:0006271)2.80295784
114DNA replication initiation (GO:0006270)2.79564025
115cell recognition (GO:0008037)2.79083231
116male meiosis I (GO:0007141)2.78632229
117germ cell development (GO:0007281)2.78457979
118nucleotide salvage (GO:0043173)2.76557300
119mitotic recombination (GO:0006312)2.76382567
120negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.76375677
121protein-DNA complex disassembly (GO:0032986)2.75668123
122nucleosome disassembly (GO:0006337)2.75668123
123protein targeting to mitochondrion (GO:0006626)2.74566585
124IMP metabolic process (GO:0046040)2.73607319
125establishment of integrated proviral latency (GO:0075713)2.73157011
126GMP metabolic process (GO:0046037)2.73105937
127UTP biosynthetic process (GO:0006228)2.72550812
128ncRNA 3-end processing (GO:0043628)2.72405985
129mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.72172211
130DNA methylation involved in gamete generation (GO:0043046)2.71729883
131sequestering of actin monomers (GO:0042989)2.71618841
132regulation of centriole replication (GO:0046599)2.71368421
133base-excision repair, AP site formation (GO:0006285)2.69982969
134protein retention in ER lumen (GO:0006621)2.69318117
135deoxyribose phosphate catabolic process (GO:0046386)2.69183312
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69098079
137viral mRNA export from host cell nucleus (GO:0046784)2.68749885
138left/right pattern formation (GO:0060972)2.68016802
139negative regulation of B cell apoptotic process (GO:0002903)2.67227530
140adenine nucleotide transport (GO:0051503)2.66717615
141sister chromatid segregation (GO:0000819)2.66614688
142negative regulation of RNA splicing (GO:0033119)2.66537756
143purine nucleobase biosynthetic process (GO:0009113)2.65544086
144meiosis I (GO:0007127)2.65357429
145cellular process involved in reproduction in multicellular organism (GO:0022412)2.64896212
146GTP biosynthetic process (GO:0006183)2.64381315
147pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.63462770
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.63149594
149nucleobase biosynthetic process (GO:0046112)2.62874659
150negative regulation of organelle assembly (GO:1902116)2.62382318
1512-deoxyribonucleotide metabolic process (GO:0009394)2.62109553
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.61305373
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60857488
154microtubule polymerization or depolymerization (GO:0031109)2.60610743
155negative regulation of erythrocyte differentiation (GO:0045647)2.60554962
156pyrimidine nucleotide biosynthetic process (GO:0006221)2.60184047
157positive regulation of synapse maturation (GO:0090129)2.59489773
158protein localization to cilium (GO:0061512)2.59463032
159negative regulation of mRNA metabolic process (GO:1903312)2.57986066
160guanosine-containing compound biosynthetic process (GO:1901070)2.57703977
161regulation of chromosome segregation (GO:0051983)2.56677855
162DNA strand elongation (GO:0022616)2.56599356
163histone exchange (GO:0043486)2.56556843
164negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.55556599
165regulation of translational termination (GO:0006449)2.55498099
166spermatid nucleus differentiation (GO:0007289)2.51872675
167negative regulation of proteasomal protein catabolic process (GO:1901799)2.51666387
168mitotic nuclear envelope disassembly (GO:0007077)2.45798269
169protein depolymerization (GO:0051261)2.44591586
170negative regulation of chromosome segregation (GO:0051985)2.44591319
171negative regulation of mitotic sister chromatid separation (GO:2000816)2.41510087
172negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41510087
173negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41510087
174negative regulation of sister chromatid segregation (GO:0033046)2.41510087
175formation of translation preinitiation complex (GO:0001731)2.40682247
176spliceosomal snRNP assembly (GO:0000387)2.40358130
177protein localization to kinetochore (GO:0034501)2.40037594
178protein insertion into membrane (GO:0051205)2.38898300
179regulation of histone H3-K9 methylation (GO:0051570)2.38399399
180postreplication repair (GO:0006301)2.38082070
181negative regulation of proteolysis involved in cellular protein catabolic process (GO:1903051)2.38047455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.16415316
2E2F7_22180533_ChIP-Seq_HELA_Human5.27809224
3EZH2_22144423_ChIP-Seq_EOC_Human4.19508230
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.47488093
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86312083
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.56730500
7* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52336916
8VDR_21846776_ChIP-Seq_THP-1_Human2.47464226
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44590531
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22589389
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16416683
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12768385
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.12499217
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10618010
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10593283
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.09909934
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09325864
18ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.07104051
19LXR_22292898_ChIP-Seq_THP-1_Human1.98381939
20THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93673026
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.93493791
22XRN2_22483619_ChIP-Seq_HELA_Human1.89520971
23* YY1_21170310_ChIP-Seq_MESCs_Mouse1.88466134
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85509789
25SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.78725509
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.76717101
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76532803
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66968731
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60353155
30SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.60267057
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57684898
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.57276256
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57031692
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56332644
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55492796
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.54614591
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53591595
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53523036
39* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52930196
40* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.51425774
41ZNF263_19887448_ChIP-Seq_K562_Human1.50673546
42GABP_19822575_ChIP-Seq_HepG2_Human1.49474700
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48905028
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.45249925
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44649498
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43995385
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42564495
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40181399
49* TTF2_22483619_ChIP-Seq_HELA_Human1.40137375
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39538547
51* CIITA_25753668_ChIP-Seq_RAJI_Human1.38880014
52REST_21632747_ChIP-Seq_MESCs_Mouse1.38165756
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38153743
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36598657
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34826381
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34803557
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34326341
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32373200
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31952140
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.31831898
61VDR_23849224_ChIP-Seq_CD4+_Human1.31616455
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29856181
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29698115
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.28455699
65RACK7_27058665_Chip-Seq_MCF-7_Human1.27848714
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27755443
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.26638438
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26087664
69FOXP3_21729870_ChIP-Seq_TREG_Human1.24885096
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24608850
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24322892
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22796145
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22345862
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22060259
75KDM2B_26808549_Chip-Seq_DND41_Human1.21724699
76NELFA_20434984_ChIP-Seq_ESCs_Mouse1.21583317
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.20175652
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20033950
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19715073
80MYC_22102868_ChIP-Seq_BL_Human1.18308607
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17094378
82* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16697549
83* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15992330
84ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14585475
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.14534123
86ZNF274_21170338_ChIP-Seq_K562_Hela1.14358220
87SMC4_20622854_ChIP-Seq_HELA_Human1.14123829
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14040448
89* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14023487
90* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12323043
91* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11204482
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11162833
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10538793
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09751608
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09025136
96BCOR_27268052_Chip-Seq_Bcells_Human1.08955957
97TCF7_22412390_ChIP-Seq_EML_Mouse1.08923671
98DCP1A_22483619_ChIP-Seq_HELA_Human1.08537552
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07304929
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06733326
101* MAF_26560356_Chip-Seq_TH2_Human1.06625327
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06088545
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05406224
104FOXP1_21924763_ChIP-Seq_HESCs_Human1.04494094
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04309225
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03702192
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03455981
108NCOR1_26117541_ChIP-Seq_K562_Human1.03103399
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03092270
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02680934
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01696850
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.01301645
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.00657768
114KDM5A_27292631_Chip-Seq_BREAST_Human0.98779874
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98102366
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98054644
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.96429016
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96197710
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95518942
120* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94605927
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93727332
122ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92284888
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92073129
124PHF8_20622854_ChIP-Seq_HELA_Human0.91862435
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89865473
126FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88352428
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88213148
128E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87698879
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87110367
130WDR5_24793694_ChIP-Seq_LNCAP_Human0.85831207
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85328601
132* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85170811
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84534287
134BCL6_27268052_Chip-Seq_Bcells_Human0.82279005
135E2F1_17053090_ChIP-ChIP_MCF-7_Human0.82265047
136P68_20966046_ChIP-Seq_HELA_Human0.80956473
137RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80267360
138EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79910726
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79880520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.63895286
2MP0008260_abnormal_autophagy3.32469719
3MP0004859_abnormal_synaptic_plasticity3.11453162
4MP0008877_abnormal_DNA_methylation3.07717166
5MP0009278_abnormal_bone_marrow3.06703024
6MP0003698_abnormal_male_reproductive3.02282575
7MP0002653_abnormal_ependyma_morphology3.01118821
8MP0001929_abnormal_gametogenesis2.77487365
9MP0010094_abnormal_chromosome_stability2.66193131
10MP0003880_abnormal_central_pattern2.60400631
11MP0003111_abnormal_nucleus_morphology2.51866486
12MP0004957_abnormal_blastocyst_morpholog2.16103138
13MP0005451_abnormal_body_composition2.11477674
14MP0003693_abnormal_embryo_hatching2.06957501
15MP0003077_abnormal_cell_cycle2.03341197
16MP0002210_abnormal_sex_determination2.02941121
17MP0003635_abnormal_synaptic_transmissio2.00982553
18MP0002822_catalepsy1.96636889
19MP0000678_abnormal_parathyroid_gland1.96460881
20MP0008058_abnormal_DNA_repair1.93984028
21MP0001968_abnormal_touch/_nociception1.90848807
22MP0002132_abnormal_respiratory_system1.84697682
23MP0002249_abnormal_larynx_morphology1.82011888
24MP0002736_abnormal_nociception_after1.80700599
25MP0001346_abnormal_lacrimal_gland1.78825596
26MP0002396_abnormal_hematopoietic_system1.78061876
27MP0001145_abnormal_male_reproductive1.77717070
28MP0004270_analgesia1.77278056
29MP0002161_abnormal_fertility/fecundity1.74941700
30MP0003806_abnormal_nucleotide_metabolis1.74188424
31MP0002160_abnormal_reproductive_system1.71132535
32MP0004233_abnormal_muscle_weight1.70040564
33MP0005423_abnormal_somatic_nervous1.67890744
34MP0009046_muscle_twitch1.67117015
35MP0002063_abnormal_learning/memory/cond1.64492961
36MP0005397_hematopoietic_system_phenotyp1.63529368
37MP0001545_abnormal_hematopoietic_system1.63529368
38MP0002877_abnormal_melanocyte_morpholog1.62702115
39MP0008932_abnormal_embryonic_tissue1.59915986
40MP0006036_abnormal_mitochondrial_physio1.57995862
41MP0001730_embryonic_growth_arrest1.57901333
42MP0005501_abnormal_skin_physiology1.55143241
43MP0003123_paternal_imprinting1.54996813
44MP0009745_abnormal_behavioral_response1.50099153
45MP0001529_abnormal_vocalization1.48114369
46MP0004133_heterotaxia1.47023192
47MP0000653_abnormal_sex_gland1.45375723
48MP0004811_abnormal_neuron_physiology1.44627313
49MP0002734_abnormal_mechanical_nocicepti1.43077754
50MP0001188_hyperpigmentation1.42755287
51MP0005058_abnormal_lysosome_morphology1.42124617
52MP0005623_abnormal_meninges_morphology1.41435628
53MP0005464_abnormal_platelet_physiology1.40762626
54MP0008007_abnormal_cellular_replicative1.39377592
55MP0002064_seizures1.37086205
56MP0002735_abnormal_chemical_nociception1.34178888
57MP0002572_abnormal_emotion/affect_behav1.32991860
58MP0003787_abnormal_imprinting1.31418447
59MP0003121_genomic_imprinting1.27873167
60MP0003122_maternal_imprinting1.20984318
61MP0000681_abnormal_thyroid_gland1.20748148
62MP0002184_abnormal_innervation1.20028977
63MP0009672_abnormal_birth_weight1.20017129
64MP0003861_abnormal_nervous_system1.19799122
65MP0005394_taste/olfaction_phenotype1.19785470
66MP0005499_abnormal_olfactory_system1.19785470
67MP0002272_abnormal_nervous_system1.18791447
68MP0005384_cellular_phenotype1.17316533
69MP0005621_abnormal_cell_physiology1.17134716
70MP0008057_abnormal_DNA_replication1.16708554
71MP0001440_abnormal_grooming_behavior1.15984016
72MP0000778_abnormal_nervous_system1.15247593
73MP0000490_abnormal_crypts_of1.12374257
74MP0001984_abnormal_olfaction1.11015745
75MP0002152_abnormal_brain_morphology1.10854288
76MP0002019_abnormal_tumor_incidence1.10290939
77MP0000003_abnormal_adipose_tissue1.10197108
78MP0000955_abnormal_spinal_cord1.08709216
79MP0002733_abnormal_thermal_nociception1.08542583
80MP0000350_abnormal_cell_proliferation1.06659302
81MP0001697_abnormal_embryo_size1.06065468
82MP0004185_abnormal_adipocyte_glucose1.05730810
83MP0003172_abnormal_lysosome_physiology1.04355837
84MP0002084_abnormal_developmental_patter1.03367572
85MP0002085_abnormal_embryonic_tissue1.03057474
86MP0001970_abnormal_pain_threshold0.98631043
87MP0002080_prenatal_lethality0.97119761
88MP0003119_abnormal_digestive_system0.96103002
89MP0003786_premature_aging0.95247670
90MP0002067_abnormal_sensory_capabilities0.94939587
91MP0002882_abnormal_neuron_morphology0.94777391
92MP0003879_abnormal_hair_cell0.94598407
93MP0001849_ear_inflammation0.93130894
94MP0001486_abnormal_startle_reflex0.91579802
95MP0002234_abnormal_pharynx_morphology0.91412599
96MP0000358_abnormal_cell_content/0.87455951
97MP0002089_abnormal_postnatal_growth/wei0.87070637
98MP0002557_abnormal_social/conspecific_i0.85973475
99MP0010307_abnormal_tumor_latency0.85719808
100MP0000537_abnormal_urethra_morphology0.85150721
101MP0003329_amyloid_beta_deposits0.84838846
102MP0000534_abnormal_ureter_morphology0.83709700
103MP0005389_reproductive_system_phenotype0.83327802
104MP0000703_abnormal_thymus_morphology0.83146868
105MP0001672_abnormal_embryogenesis/_devel0.82949446
106MP0005380_embryogenesis_phenotype0.82949446
107MP0000049_abnormal_middle_ear0.82780114
108MP0000465_gastrointestinal_hemorrhage0.82284215
109MP0000858_altered_metastatic_potential0.81445009
110MP0003315_abnormal_perineum_morphology0.80379720
111MP0006276_abnormal_autonomic_nervous0.79760216
112MP0009333_abnormal_splenocyte_physiolog0.79620715
113MP0003705_abnormal_hypodermis_morpholog0.79305585
114MP0002796_impaired_skin_barrier0.78183143
115MP0008569_lethality_at_weaning0.77484050
116MP0002066_abnormal_motor_capabilities/c0.76929517
117MP0000313_abnormal_cell_death0.76637351
118MP0008789_abnormal_olfactory_epithelium0.76615465
119MP0003283_abnormal_digestive_organ0.76140271
120MP0003646_muscle_fatigue0.75243818
121MP0000751_myopathy0.75147275
122MP0002751_abnormal_autonomic_nervous0.73376760
123MP0001270_distended_abdomen0.73300754
124MP0010030_abnormal_orbit_morphology0.72941868
125MP0006072_abnormal_retinal_apoptosis0.72211795
126MP0003436_decreased_susceptibility_to0.71583977
127MP0006035_abnormal_mitochondrial_morpho0.71522307
128MP0001905_abnormal_dopamine_level0.71260725
129MP0004924_abnormal_behavior0.71190191
130MP0005386_behavior/neurological_phenoty0.71190191
131MP0004858_abnormal_nervous_system0.70907011
132MP0002088_abnormal_embryonic_growth/wei0.70896440
133MP0005670_abnormal_white_adipose0.70893185
134MP0003890_abnormal_embryonic-extraembry0.70582971
135MP0004808_abnormal_hematopoietic_stem0.70473900
136MP0003942_abnormal_urinary_system0.70400946
137MP0002102_abnormal_ear_morphology0.69734152
138MP0004197_abnormal_fetal_growth/weight/0.69213772
139MP0003984_embryonic_growth_retardation0.68717454
140MP0004145_abnormal_muscle_electrophysio0.68277156
141MP0008874_decreased_physiological_sensi0.67570155
142MP0003566_abnormal_cell_adhesion0.66371451
143MP0000747_muscle_weakness0.65204383
144MP0003191_abnormal_cellular_cholesterol0.64415773
145MP0005076_abnormal_cell_differentiation0.64260808
146MP0003186_abnormal_redox_activity0.64211646
147MP0008873_increased_physiological_sensi0.63880697
148MP0002873_normal_phenotype0.63716428
149MP0005171_absent_coat_pigmentation0.63518079
150MP0002169_no_abnormal_phenotype0.63304915

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.82437706
2Absent/shortened dynein arms (HP:0200106)6.82437706
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.81537150
4Abnormal respiratory epithelium morphology (HP:0012253)5.26512479
5Abnormal respiratory motile cilium morphology (HP:0005938)5.26512479
6Abnormal respiratory motile cilium physiology (HP:0012261)5.18153394
7Rhinitis (HP:0012384)4.49346940
8Abnormal ciliary motility (HP:0012262)4.12595926
9Cholecystitis (HP:0001082)4.10439276
10Abnormal gallbladder physiology (HP:0012438)4.10439276
11Microvesicular hepatic steatosis (HP:0001414)3.96704695
12Chronic bronchitis (HP:0004469)3.87635231
13Ragged-red muscle fibers (HP:0003200)3.67896372
14Infertility (HP:0000789)3.49024737
15Nasal polyposis (HP:0100582)3.36197410
16Nephronophthisis (HP:0000090)3.16875854
17Amyotrophic lateral sclerosis (HP:0007354)2.99585460
18Abnormality of the lower motor neuron (HP:0002366)2.98659278
19Abnormality of glycolysis (HP:0004366)2.93780215
20Atelectasis (HP:0100750)2.85275168
21Annular pancreas (HP:0001734)2.82038804
22Truncus arteriosus (HP:0001660)2.75271353
23Hand muscle atrophy (HP:0009130)2.74932004
24Distal upper limb amyotrophy (HP:0007149)2.71842549
25Upper limb amyotrophy (HP:0009129)2.71842549
26Cerebral hypomyelination (HP:0006808)2.71105818
27Myokymia (HP:0002411)2.65896629
28Multiple enchondromatosis (HP:0005701)2.62512914
29Progressive muscle weakness (HP:0003323)2.56213845
30Cholelithiasis (HP:0001081)2.51636795
31Rough bone trabeculation (HP:0100670)2.46337508
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46270282
33Abnormality of the nasal mucosa (HP:0000433)2.44185777
34Abnormality of midbrain morphology (HP:0002418)2.37026696
35Molar tooth sign on MRI (HP:0002419)2.37026696
36Bronchiectasis (HP:0002110)2.35036169
37Reticulocytosis (HP:0001923)2.34970095
38Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34491949
39Myopathic facies (HP:0002058)2.31878206
40Increased serum pyruvate (HP:0003542)2.31008592
41Bronchitis (HP:0012387)2.30675373
42Testicular atrophy (HP:0000029)2.30383720
43Supranuclear gaze palsy (HP:0000605)2.25217339
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.19464556
45Hyperthyroidism (HP:0000836)2.18014166
46Impulsivity (HP:0100710)2.17809611
47Increased intramyocellular lipid droplets (HP:0012240)2.16424367
48Ulnar bowing (HP:0003031)2.14626490
49Hypertensive crisis (HP:0100735)2.14616326
50Depression (HP:0000716)2.14308099
51Medial flaring of the eyebrow (HP:0010747)2.13711991
52Progressive external ophthalmoplegia (HP:0000590)2.12895814
53Increased muscle lipid content (HP:0009058)2.12205102
54Abnormality of reticulocytes (HP:0004312)2.11297368
55Visual hallucinations (HP:0002367)2.10746297
56Broad distal phalanx of finger (HP:0009836)2.10388007
57Hypoplasia of the brainstem (HP:0002365)2.09915565
58Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09915565
59Self-mutilation (HP:0000742)2.09784552
60Abnormal mitochondria in muscle tissue (HP:0008316)2.09611222
61Degeneration of anterior horn cells (HP:0002398)2.08963577
62Abnormality of the anterior horn cell (HP:0006802)2.08963577
63CNS hypomyelination (HP:0003429)2.08746851
64Abnormality of cells of the erythroid lineage (HP:0012130)2.08288839
65Peripheral hypomyelination (HP:0007182)2.08226950
66Ependymoma (HP:0002888)2.05859468
67Hepatocellular necrosis (HP:0001404)2.05846655
68Neuronal loss in central nervous system (HP:0002529)2.04938898
69Abnormal number of erythroid precursors (HP:0012131)2.02100388
70Abnormal gallbladder morphology (HP:0012437)2.01995310
71Medulloblastoma (HP:0002885)2.01762101
72Progressive microcephaly (HP:0000253)2.01254732
73Impaired smooth pursuit (HP:0007772)2.01090092
74Exercise intolerance (HP:0003546)2.00787860
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.00020619
76Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.00020619
77Trismus (HP:0000211)1.99731703
78Emotional lability (HP:0000712)1.98399647
79Abnormality of ocular smooth pursuit (HP:0000617)1.97833117
80Petechiae (HP:0000967)1.97831191
81Delusions (HP:0000746)1.96935451
82Microretrognathia (HP:0000308)1.96893452
83Transposition of the great arteries (HP:0001669)1.96867723
84Abnormal connection of the cardiac segments (HP:0011545)1.96867723
85Abnormal ventriculo-arterial connection (HP:0011563)1.96867723
86Retinal dysplasia (HP:0007973)1.96855472
87Insomnia (HP:0100785)1.96697311
88Focal motor seizures (HP:0011153)1.95689797
89Abnormality of the renal medulla (HP:0100957)1.94892345
90Carpal bone hypoplasia (HP:0001498)1.93662844
91Abnormality of the gallbladder (HP:0005264)1.92660533
92Personality changes (HP:0000751)1.91224106
93Facial cleft (HP:0002006)1.90485946
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.89214594
95Selective tooth agenesis (HP:0001592)1.88527124
96Abnormality of the umbilical cord (HP:0010881)1.87673219
97Epileptic encephalopathy (HP:0200134)1.87626533
98Upper limb muscle weakness (HP:0003484)1.86306473
99Achilles tendon contracture (HP:0001771)1.84155538
100Premature ovarian failure (HP:0008209)1.83861872
101Lissencephaly (HP:0001339)1.83728196
102Long palpebral fissure (HP:0000637)1.82885034
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82664312
104Short 4th metacarpal (HP:0010044)1.82664312
105Neoplasm of the heart (HP:0100544)1.80522335
106Gait imbalance (HP:0002141)1.80338189
107Stridor (HP:0010307)1.80226221
108Recurrent otitis media (HP:0000403)1.78954447
109Abnormality of the labia minora (HP:0012880)1.78094517
110Hyperacusis (HP:0010780)1.77940155
111Abnormality of the heme biosynthetic pathway (HP:0010472)1.77476461
112Focal seizures (HP:0007359)1.75539381
113Muscle stiffness (HP:0003552)1.75145994
114Unsteady gait (HP:0002317)1.73474149
115Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71970115
116Abnormal umbilical cord blood vessels (HP:0011403)1.71938033
117Single umbilical artery (HP:0001195)1.71938033
118Abnormality of the fetal cardiovascular system (HP:0010948)1.71938033
119Abnormal large intestine physiology (HP:0012700)1.71606784
120Pointed chin (HP:0000307)1.70979140
121Short ribs (HP:0000773)1.69518971
122Heterotopia (HP:0002282)1.68754598
123Seborrheic dermatitis (HP:0001051)1.68696618
124Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67211399
125Absent epiphyses (HP:0010577)1.67211399
126External ophthalmoplegia (HP:0000544)1.66894164
127Premature skin wrinkling (HP:0100678)1.66697574
128Athetosis (HP:0002305)1.66614865
129Hepatic necrosis (HP:0002605)1.66280785
130Abnormality of the astrocytes (HP:0100707)1.64998951
131Astrocytoma (HP:0009592)1.64998951
132Male infertility (HP:0003251)1.62499755
133Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.62378574
134Renal duplication (HP:0000075)1.62181287
135Postaxial foot polydactyly (HP:0001830)1.61480601
13611 pairs of ribs (HP:0000878)1.61370743
137Oculomotor apraxia (HP:0000657)1.60767968
138Pancreatic fibrosis (HP:0100732)1.59869335
139Congenital primary aphakia (HP:0007707)1.58535180
140Mutism (HP:0002300)1.57408851
141Increased nuchal translucency (HP:0010880)1.56288062
142Basal cell carcinoma (HP:0002671)1.56009331
143Abnormality of abdominal situs (HP:0011620)1.55500177
144Abdominal situs inversus (HP:0003363)1.55500177
145Supernumerary spleens (HP:0009799)1.54390391
146Amblyopia (HP:0000646)1.53445469
147Gaze-evoked nystagmus (HP:0000640)1.51334150
148Patellar aplasia (HP:0006443)1.50859272
149Progressive cerebellar ataxia (HP:0002073)1.49436536
150Abnormal neuron morphology (HP:0012757)1.49372383
151Abnormality of the motor neurons (HP:0002450)1.49372383
152Impaired vibration sensation in the lower limbs (HP:0002166)1.49063996
153Hemiparesis (HP:0001269)1.48758748
154Ankle clonus (HP:0011448)1.46676632
155Atonic seizures (HP:0010819)1.46644635
156Postaxial hand polydactyly (HP:0001162)1.46388727
157True hermaphroditism (HP:0010459)1.46008317
158Breast hypoplasia (HP:0003187)1.43658561
159Choroideremia (HP:0001139)1.43335846
160Birth length less than 3rd percentile (HP:0003561)1.41318981
161Truncal ataxia (HP:0002078)1.41304263
162Optic nerve coloboma (HP:0000588)1.39854983
163Sloping forehead (HP:0000340)1.39559319
164Specific learning disability (HP:0001328)1.38852204
165Neoplasm of striated muscle (HP:0009728)1.38177605
166Hypoplasia of the pons (HP:0012110)1.38042413
167Abnormality of dentin (HP:0010299)1.38020328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.58523181
2PDK34.36734689
3PDK44.36734689
4SMG13.83265843
5BUB13.36596922
6PRKD33.35472670
7NME23.01916227
8TRIB32.83407580
9PNCK2.76922177
10ICK2.56505117
11CDC72.55117484
12BCKDK2.45979184
13VRK22.39891737
14CCNB12.26911801
15TESK22.23766605
16PDK22.19460306
17WEE12.16481586
18NEK22.08114063
19MAP3K112.00280646
20MAP2K31.98680046
21EEF2K1.91008916
22CDK191.85815214
23MARK11.81122798
24EIF2AK11.79847015
25PIM21.78040822
26PRPF4B1.72924367
27MAP3K91.72305444
28KDR1.64763929
29NEK11.63160730
30MAP3K101.58668650
31IRAK31.58344789
32PTK2B1.52485568
33TLK11.51726987
34MINK11.50829296
35PBK1.37448244
36IRAK21.32854250
37TSSK61.29398312
38DAPK11.24104325
39ERN11.23864768
40BRSK11.21537940
41CSNK1G31.18910428
42NTRK31.18117948
43UHMK11.17287627
44TAOK21.15142852
45EPHA41.14610352
46DYRK31.10478409
47PLK11.09527801
48CDK181.08851890
49NTRK21.07845100
50TTK1.07806722
51MAP3K41.06326571
52STK381.05069579
53CDK151.05056499
54PAK61.03672278
55CDK11A1.01435178
56SIK31.00550288
57SRPK11.00285358
58SIK20.99893641
59AURKA0.99745518
60CDK140.97984700
61NME10.96286596
62KSR10.93859062
63DAPK20.91438522
64ATR0.91343779
65CSNK1A1L0.89056835
66PAK10.87919281
67SIK10.87320208
68TYRO30.86562399
69MAPK110.83558803
70CHEK20.83069401
71EPHA20.80102846
72LMTK20.79422560
73PKN20.77637069
74CHEK10.75651734
75RAF10.75104972
76CSNK1G20.75082783
77PRKCG0.71858311
78LIMK10.71763163
79LRRK20.71688850
80PAK40.70458565
81LATS20.70158343
82SCYL20.68657986
83MAP2K40.68505579
84ARAF0.67985526
85AKT20.67021858
86BRAF0.64991140
87PLK30.64834869
88PASK0.64076875
89STK160.59452316
90CASK0.58952316
91DYRK20.58757020
92GRK60.57721689
93BMX0.57073974
94CSNK1G10.56767932
95CDK70.56126566
96NTRK10.55416206
97RIPK40.55288192
98PLK20.53695274
99CAMKK10.52957284
100EPHB10.52823435
101CDK50.52207590
102TNK20.51131075
103DYRK1B0.51109631
104CDK20.51091580
105GRK50.50128956
106PDPK10.48727235
107CDK90.48720959
108MAP3K120.47958025
109DAPK30.46871265
110RPS6KA50.46494062
111ALK0.45819290
112VRK10.45500828
113MAPK130.44933589
114RPS6KA40.44444860
115AURKB0.44124838
116ABL20.44111525
117KSR20.42973257
118PRKD20.42155892
119ILK0.41699689
120CDK10.40395558
121MAP3K80.40325172
122ATM0.40138419
123PDK10.39761235
124PRKCI0.39506552
125MTOR0.39299311
126TAOK10.38479574
127PLK40.38316336
128IRAK40.37876587
129ACVR1B0.37685822
130MAPK120.37444932
131CDK80.36590705
132MARK20.35496041
133RPS6KB10.35397344
134MAP2K70.35296610
135BRSK20.34690830
136CDK40.32929862
137RPS6KA20.32875843
138MAP2K60.32637463
139STK110.32274752
140MAPKAPK30.32016913
141WNK40.31633972
142CDK120.30610425

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.12292633
2Sulfur relay system_Homo sapiens_hsa041222.89082400
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.72516216
4Spliceosome_Homo sapiens_hsa030402.45042300
5RNA transport_Homo sapiens_hsa030132.33030565
6Mismatch repair_Homo sapiens_hsa034302.27342065
7Proteasome_Homo sapiens_hsa030502.24875040
8Oocyte meiosis_Homo sapiens_hsa041142.23212436
9Synaptic vesicle cycle_Homo sapiens_hsa047212.13870763
10mRNA surveillance pathway_Homo sapiens_hsa030151.88217770
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85680700
12RNA polymerase_Homo sapiens_hsa030201.85204339
13Carbon metabolism_Homo sapiens_hsa012001.84465376
14Cell cycle_Homo sapiens_hsa041101.84316004
15Base excision repair_Homo sapiens_hsa034101.79102570
16Basal transcription factors_Homo sapiens_hsa030221.71215937
17Nicotine addiction_Homo sapiens_hsa050331.64934537
18Nucleotide excision repair_Homo sapiens_hsa034201.62428821
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61762815
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61459726
21Amphetamine addiction_Homo sapiens_hsa050311.60110009
22Ribosome_Homo sapiens_hsa030101.58757684
23Long-term potentiation_Homo sapiens_hsa047201.55242194
24Huntingtons disease_Homo sapiens_hsa050161.54886843
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.52439431
26Fanconi anemia pathway_Homo sapiens_hsa034601.42331567
27Pyrimidine metabolism_Homo sapiens_hsa002401.42101832
28Olfactory transduction_Homo sapiens_hsa047401.37873624
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36215267
30Cardiac muscle contraction_Homo sapiens_hsa042601.35553230
31Homologous recombination_Homo sapiens_hsa034401.35049966
32Parkinsons disease_Homo sapiens_hsa050121.33404530
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31850977
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31211471
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27268521
36One carbon pool by folate_Homo sapiens_hsa006701.21194778
37Dopaminergic synapse_Homo sapiens_hsa047281.20588862
38Non-small cell lung cancer_Homo sapiens_hsa052231.18472763
39Alcoholism_Homo sapiens_hsa050341.18023110
40Purine metabolism_Homo sapiens_hsa002301.17683940
41Collecting duct acid secretion_Homo sapiens_hsa049661.15017427
42RNA degradation_Homo sapiens_hsa030181.14085861
43Circadian entrainment_Homo sapiens_hsa047131.13464098
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11098911
45Galactose metabolism_Homo sapiens_hsa000521.10187640
46Oxidative phosphorylation_Homo sapiens_hsa001901.07754442
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07707115
48Fatty acid elongation_Homo sapiens_hsa000620.98399489
49Bladder cancer_Homo sapiens_hsa052190.96597861
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.96346212
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95664145
52Glutamatergic synapse_Homo sapiens_hsa047240.95226331
53Glucagon signaling pathway_Homo sapiens_hsa049220.91616599
54N-Glycan biosynthesis_Homo sapiens_hsa005100.91339620
55Pyruvate metabolism_Homo sapiens_hsa006200.91233651
56Hedgehog signaling pathway_Homo sapiens_hsa043400.89519733
57Chronic myeloid leukemia_Homo sapiens_hsa052200.89046735
58Epstein-Barr virus infection_Homo sapiens_hsa051690.88627859
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88383835
60Non-homologous end-joining_Homo sapiens_hsa034500.86346838
61Folate biosynthesis_Homo sapiens_hsa007900.86301767
62Acute myeloid leukemia_Homo sapiens_hsa052210.85998506
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85906358
64Alzheimers disease_Homo sapiens_hsa050100.85247939
65Gap junction_Homo sapiens_hsa045400.83992421
66Estrogen signaling pathway_Homo sapiens_hsa049150.82062868
67Morphine addiction_Homo sapiens_hsa050320.81409220
68Fructose and mannose metabolism_Homo sapiens_hsa000510.80335916
69Salivary secretion_Homo sapiens_hsa049700.79722814
70Insulin secretion_Homo sapiens_hsa049110.79000401
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78477617
72Pancreatic cancer_Homo sapiens_hsa052120.77994216
73Phototransduction_Homo sapiens_hsa047440.77499630
74Notch signaling pathway_Homo sapiens_hsa043300.76105809
75Gastric acid secretion_Homo sapiens_hsa049710.74793815
76Oxytocin signaling pathway_Homo sapiens_hsa049210.73422125
77Vibrio cholerae infection_Homo sapiens_hsa051100.71428908
78Systemic lupus erythematosus_Homo sapiens_hsa053220.71257735
79Glutathione metabolism_Homo sapiens_hsa004800.70821802
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.70598177
81VEGF signaling pathway_Homo sapiens_hsa043700.69047087
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.67582983
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67231976
84Taste transduction_Homo sapiens_hsa047420.66885179
85GABAergic synapse_Homo sapiens_hsa047270.65964326
86Renin secretion_Homo sapiens_hsa049240.65905825
87Calcium signaling pathway_Homo sapiens_hsa040200.65492689
88Cocaine addiction_Homo sapiens_hsa050300.65381490
89Shigellosis_Homo sapiens_hsa051310.64851138
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62331130
91Endocytosis_Homo sapiens_hsa041440.62256837
92Viral carcinogenesis_Homo sapiens_hsa052030.60497099
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60162310
94Basal cell carcinoma_Homo sapiens_hsa052170.60124090
95Colorectal cancer_Homo sapiens_hsa052100.59113031
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58643078
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57803109
98Cholinergic synapse_Homo sapiens_hsa047250.57799926
99HTLV-I infection_Homo sapiens_hsa051660.57588236
100Vitamin B6 metabolism_Homo sapiens_hsa007500.57478453
101Arginine and proline metabolism_Homo sapiens_hsa003300.57228418
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56749164
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55976391
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55859444
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55801321
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55354463
107Pentose phosphate pathway_Homo sapiens_hsa000300.54850102
108Wnt signaling pathway_Homo sapiens_hsa043100.54067247
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53601288
110Glioma_Homo sapiens_hsa052140.52872203
111Inositol phosphate metabolism_Homo sapiens_hsa005620.52832450
112Axon guidance_Homo sapiens_hsa043600.52579292
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52198016
114Phenylalanine metabolism_Homo sapiens_hsa003600.51785227
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51484628
116Long-term depression_Homo sapiens_hsa047300.51288746
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51175559
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51025330
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49632171
120Biosynthesis of amino acids_Homo sapiens_hsa012300.47470793
121Melanogenesis_Homo sapiens_hsa049160.46974208
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45885409
123Hippo signaling pathway_Homo sapiens_hsa043900.45255635
124Thyroid cancer_Homo sapiens_hsa052160.43744335
125Antigen processing and presentation_Homo sapiens_hsa046120.42168684
126Endometrial cancer_Homo sapiens_hsa052130.41776245
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41657658
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41490162
129HIF-1 signaling pathway_Homo sapiens_hsa040660.40154813
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.39946205
131p53 signaling pathway_Homo sapiens_hsa041150.39038470
132Metabolic pathways_Homo sapiens_hsa011000.38863409
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38826115
134GnRH signaling pathway_Homo sapiens_hsa049120.38450261
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36174927
136ErbB signaling pathway_Homo sapiens_hsa040120.34617220
137mTOR signaling pathway_Homo sapiens_hsa041500.33999289
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33709916
139Apoptosis_Homo sapiens_hsa042100.32892859
140Salmonella infection_Homo sapiens_hsa051320.30871692
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29567213
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29257113
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28675281

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