KATNBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.17116845
2regulation of heat generation (GO:0031650)5.06906761
3cerebral cortex radially oriented cell migration (GO:0021799)4.71263268
4behavioral response to nicotine (GO:0035095)4.40887243
5metaphase plate congression (GO:0051310)4.32646742
6CENP-A containing nucleosome assembly (GO:0034080)4.08796100
7protein localization to kinetochore (GO:0034501)4.03368408
8kinetochore organization (GO:0051383)4.01139327
9chromatin remodeling at centromere (GO:0031055)3.99628349
10establishment of chromosome localization (GO:0051303)3.92528217
11regulation of spindle organization (GO:0090224)3.92383447
12preassembly of GPI anchor in ER membrane (GO:0016254)3.92185683
13attachment of spindle microtubules to kinetochore (GO:0008608)3.75022958
14neural tube formation (GO:0001841)3.74226778
15kinetochore assembly (GO:0051382)3.72157444
16DNA replication-independent nucleosome organization (GO:0034724)3.72029482
17DNA replication-independent nucleosome assembly (GO:0006336)3.72029482
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.69518025
19DNA replication checkpoint (GO:0000076)3.66731147
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65788836
21ribosome assembly (GO:0042255)3.62947603
22protein localization to chromosome, centromeric region (GO:0071459)3.58552972
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.54546995
24positive regulation of chromosome segregation (GO:0051984)3.54381444
25limb bud formation (GO:0060174)3.53803556
26mitotic nuclear envelope disassembly (GO:0007077)3.50767776
27response to pheromone (GO:0019236)3.49178967
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48732551
29establishment of nucleus localization (GO:0040023)3.46088363
30protein K6-linked ubiquitination (GO:0085020)3.44857819
31nuclear pore organization (GO:0006999)3.44173711
32spindle checkpoint (GO:0031577)3.44128105
33resolution of meiotic recombination intermediates (GO:0000712)3.42938678
34water-soluble vitamin biosynthetic process (GO:0042364)3.41659792
35DNA replication initiation (GO:0006270)3.41388663
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41258239
37GPI anchor metabolic process (GO:0006505)3.39245469
38adaptation of signaling pathway (GO:0023058)3.35791426
39regulation of cilium movement (GO:0003352)3.35377119
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33426785
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33426785
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.33426785
43somite development (GO:0061053)3.33105192
44nuclear pore complex assembly (GO:0051292)3.32420568
45fucose catabolic process (GO:0019317)3.31706898
46L-fucose metabolic process (GO:0042354)3.31706898
47L-fucose catabolic process (GO:0042355)3.31706898
48purine nucleobase biosynthetic process (GO:0009113)3.30922446
49cerebral cortex cell migration (GO:0021795)3.29785248
50meiotic chromosome segregation (GO:0045132)3.29624005
51histone exchange (GO:0043486)3.29510569
52maturation of 5.8S rRNA (GO:0000460)3.29417463
53membrane disassembly (GO:0030397)3.29308224
54nuclear envelope disassembly (GO:0051081)3.29308224
55maturation of SSU-rRNA (GO:0030490)3.28806660
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28726455
57mannosylation (GO:0097502)3.28316784
58head development (GO:0060322)3.26767555
59negative regulation of mast cell activation (GO:0033004)3.25066754
60cellular response to nerve growth factor stimulus (GO:1990090)3.23685474
61response to nerve growth factor (GO:1990089)3.23685474
62formation of translation preinitiation complex (GO:0001731)3.23250285
63mitotic chromosome condensation (GO:0007076)3.22768260
64regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22074762
65rRNA modification (GO:0000154)3.19215363
66DNA double-strand break processing (GO:0000729)3.18982528
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18298004
68regulation of mitotic spindle organization (GO:0060236)3.17512404
69spindle assembly checkpoint (GO:0071173)3.16257517
70negative regulation of sister chromatid segregation (GO:0033046)3.15995620
71negative regulation of mitotic sister chromatid separation (GO:2000816)3.15995620
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15995620
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15995620
74regulation of chromosome segregation (GO:0051983)3.15561610
75mitotic spindle checkpoint (GO:0071174)3.15186448
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.14224750
77intraciliary transport (GO:0042073)3.13773657
78negative regulation of chromosome segregation (GO:0051985)3.13355138
79mitotic spindle assembly checkpoint (GO:0007094)3.13004553
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11286849
81ribosome biogenesis (GO:0042254)3.09556590
82pyrimidine nucleobase catabolic process (GO:0006208)3.09157063
83microtubule depolymerization (GO:0007019)3.08450808
84protein localization to endosome (GO:0036010)3.07903078
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.07358953
86DNA strand elongation involved in DNA replication (GO:0006271)3.07284008
87nucleoside diphosphate catabolic process (GO:0009134)3.05246656
88nucleobase biosynthetic process (GO:0046112)3.04163912
89regulation of sister chromatid segregation (GO:0033045)3.00913764
90regulation of mitotic sister chromatid separation (GO:0010965)3.00913764
91regulation of mitotic sister chromatid segregation (GO:0033047)3.00913764
92DNA replication-dependent nucleosome assembly (GO:0006335)3.00693646
93DNA replication-dependent nucleosome organization (GO:0034723)3.00693646
94C-terminal protein lipidation (GO:0006501)3.00606261
95substrate-independent telencephalic tangential migration (GO:0021826)3.00042998
96substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.00042998
97C-terminal protein amino acid modification (GO:0018410)2.99323960
98atrial cardiac muscle cell action potential (GO:0086014)2.99312618
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98689340
100proteasome assembly (GO:0043248)2.98329539
101telomere maintenance via recombination (GO:0000722)2.98191299
102mitotic sister chromatid segregation (GO:0000070)2.97287860
103detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96888283
104telomere maintenance via semi-conservative replication (GO:0032201)2.94795940
105epithelial cilium movement (GO:0003351)2.94707669
106DNA-dependent DNA replication (GO:0006261)2.94325902
107cilium morphogenesis (GO:0060271)2.94150998
108DNA strand elongation (GO:0022616)2.94047934
109behavioral response to ethanol (GO:0048149)2.93474011
110oxidative phosphorylation (GO:0006119)2.92497316
111replication fork processing (GO:0031297)2.92441887
112chromosome segregation (GO:0007059)2.91498651
113mitotic recombination (GO:0006312)2.91254531
114intracellular lipid transport (GO:0032365)2.90594624
115regulation of centrosome cycle (GO:0046605)2.89741435
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88545822
117IMP biosynthetic process (GO:0006188)2.88490426
118ribosomal large subunit biogenesis (GO:0042273)2.87810438
119nonmotile primary cilium assembly (GO:0035058)2.87655913
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87165644
121rRNA methylation (GO:0031167)2.86991583
122respiratory chain complex IV assembly (GO:0008535)2.84031856
123protein polyglutamylation (GO:0018095)2.81622616
124presynaptic membrane assembly (GO:0097105)2.81008591
125mitotic G2/M transition checkpoint (GO:0044818)2.80824480
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80358076
127regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.80315980
128axoneme assembly (GO:0035082)2.80145337
129regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.79842302
130ribonucleoprotein complex biogenesis (GO:0022613)2.79716585
131platelet dense granule organization (GO:0060155)2.79519929
132C4-dicarboxylate transport (GO:0015740)2.79447695
133piRNA metabolic process (GO:0034587)2.78169844
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77767538
135protein localization to chromosome (GO:0034502)2.76941585
136protein prenylation (GO:0018342)2.76066356
137prenylation (GO:0097354)2.76066356
138olfactory bulb development (GO:0021772)2.74986600
139intra-S DNA damage checkpoint (GO:0031573)2.73974899
140establishment of protein localization to Golgi (GO:0072600)2.72708044
141telomere maintenance via telomere lengthening (GO:0010833)2.71997453
142regulation of mitotic spindle checkpoint (GO:1903504)2.71976804
143regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71976804
144ribosomal small subunit assembly (GO:0000028)2.70305721
145regulation of sister chromatid cohesion (GO:0007063)2.69561550
146sister chromatid segregation (GO:0000819)2.69104911
147mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69104406
148mitochondrial respiratory chain complex I assembly (GO:0032981)2.69104406
149NADH dehydrogenase complex assembly (GO:0010257)2.69104406
150rRNA processing (GO:0006364)2.68991995
151protein K11-linked ubiquitination (GO:0070979)2.68718178
152monoubiquitinated protein deubiquitination (GO:0035520)2.68295350
153cell cycle G1/S phase transition (GO:0044843)2.68046094
154G1/S transition of mitotic cell cycle (GO:0000082)2.68046094
155N-terminal protein amino acid acetylation (GO:0006474)2.65875904
156mitotic sister chromatid cohesion (GO:0007064)2.65102491
157transcription-coupled nucleotide-excision repair (GO:0006283)2.64820555
158DNA deamination (GO:0045006)2.63813597
159cilium organization (GO:0044782)2.63729332
160mitotic G2 DNA damage checkpoint (GO:0007095)2.63334576
161cilium assembly (GO:0042384)2.62584906
162pore complex assembly (GO:0046931)2.62127653
163negative regulation of mitosis (GO:0045839)2.61967284
164protein localization to cilium (GO:0061512)2.61805746
165negative regulation of DNA-dependent DNA replication (GO:2000104)2.61555229
166negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61447722
167hindbrain development (GO:0030902)2.61054689
168IMP metabolic process (GO:0046040)2.60441275
169protein complex biogenesis (GO:0070271)2.59675690
1707-methylguanosine mRNA capping (GO:0006370)2.59401976
171regulation of collateral sprouting (GO:0048670)2.58570467
172ether lipid metabolic process (GO:0046485)2.57584231
173chromatin assembly or disassembly (GO:0006333)2.57247505
174rRNA metabolic process (GO:0016072)2.57033664
1757-methylguanosine RNA capping (GO:0009452)2.56200878
176sympathetic nervous system development (GO:0048485)2.55016423
177centriole replication (GO:0007099)2.53622253
178recombinational repair (GO:0000725)2.52845487
179tryptophan catabolic process (GO:0006569)2.52695394
180indole-containing compound catabolic process (GO:0042436)2.52695394
181indolalkylamine catabolic process (GO:0046218)2.52695394
182negative regulation of nucleotide biosynthetic process (GO:0030809)2.51761570
183negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.51761570
184L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51124317
185neuron cell-cell adhesion (GO:0007158)2.50321937
186G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49261793
187double-strand break repair via homologous recombination (GO:0000724)2.48805561
188regulation of actin nucleation (GO:0051125)2.48206352
189negative regulation of multicellular organism growth (GO:0040015)2.47615081
190positive regulation of cardiac muscle cell differentiation (GO:2000727)2.47562921
191protein targeting to Golgi (GO:0000042)2.47145792
192tachykinin receptor signaling pathway (GO:0007217)2.47114862
193GPI anchor biosynthetic process (GO:0006506)2.47030574
194nucleobase catabolic process (GO:0046113)2.46736698
195negative regulation of transcription regulatory region DNA binding (GO:2000678)2.45974535
196cytochrome complex assembly (GO:0017004)2.45799682
197mitochondrial respiratory chain complex assembly (GO:0033108)2.45737170
198S-adenosylmethionine metabolic process (GO:0046500)2.42483157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.10984471
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60075494
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.87776522
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.80281418
5GBX2_23144817_ChIP-Seq_PC3_Human3.64485686
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.50322807
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26994061
8ZNF274_21170338_ChIP-Seq_K562_Hela3.12007961
9POU3F2_20337985_ChIP-ChIP_501MEL_Human3.11217013
10IGF1R_20145208_ChIP-Seq_DFB_Human3.00361060
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.97228025
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.93220815
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.89403389
14TAF15_26573619_Chip-Seq_HEK293_Human2.87577909
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68924811
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.63887698
17EWS_26573619_Chip-Seq_HEK293_Human2.63354519
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61930508
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59364952
20VDR_22108803_ChIP-Seq_LS180_Human2.53339576
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50537883
22AR_21909140_ChIP-Seq_LNCAP_Human2.47833957
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47693090
24EZH2_22144423_ChIP-Seq_EOC_Human2.45573523
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42753656
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.42479917
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38239845
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33957934
29ELK1_19687146_ChIP-ChIP_HELA_Human2.33532849
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.33303365
31FUS_26573619_Chip-Seq_HEK293_Human2.32105464
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26851384
33VDR_23849224_ChIP-Seq_CD4+_Human2.26099641
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25889033
35EGR1_19374776_ChIP-ChIP_THP-1_Human2.23496015
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22960712
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.22506355
38P300_19829295_ChIP-Seq_ESCs_Human2.21619758
39CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15931152
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14700475
41E2F1_21310950_ChIP-Seq_MCF-7_Human2.12133268
42PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10302316
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00681809
44XRN2_22483619_ChIP-Seq_HELA_Human1.99401172
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97984471
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97403058
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95643746
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.95061150
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92352484
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91901163
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.91765617
52DCP1A_22483619_ChIP-Seq_HELA_Human1.86498530
53ER_23166858_ChIP-Seq_MCF-7_Human1.85430587
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82851501
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80106541
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78733984
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73889099
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.71748909
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70210710
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68478456
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67897486
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66745638
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66121361
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65965391
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65375564
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.64454323
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63982336
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.63865627
69FOXP3_21729870_ChIP-Seq_TREG_Human1.63182025
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62871079
71TTF2_22483619_ChIP-Seq_HELA_Human1.62725540
72GABP_19822575_ChIP-Seq_HepG2_Human1.62274009
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60844683
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58682950
75SMAD4_21799915_ChIP-Seq_A2780_Human1.56979817
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54960605
77CBP_20019798_ChIP-Seq_JUKART_Human1.54960605
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.54285220
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54169691
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53704124
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53326470
82STAT3_23295773_ChIP-Seq_U87_Human1.52080818
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51664578
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51445747
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51372889
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51262519
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48731836
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48577031
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.47304163
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47135935
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.45749438
92SRF_21415370_ChIP-Seq_HL-1_Mouse1.44292107
93IRF8_21731497_ChIP-ChIP_J774_Mouse1.44199374
94SOX2_19829295_ChIP-Seq_ESCs_Human1.43882075
95NANOG_19829295_ChIP-Seq_ESCs_Human1.43882075
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41728848
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41663241
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.40508697
99IRF1_19129219_ChIP-ChIP_H3396_Human1.39561196
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39379541
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38812043
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37296888
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.36654408
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35903107
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35049213
106P53_22387025_ChIP-Seq_ESCs_Mouse1.33732604
107AR_25329375_ChIP-Seq_VCAP_Human1.33561149
108TCF4_23295773_ChIP-Seq_U87_Human1.32841242
109TP53_22573176_ChIP-Seq_HFKS_Human1.31923199
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27424325
111TCF4_22108803_ChIP-Seq_LS180_Human1.27210317
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26837714
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26837714
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.25762022
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25340636
116TFEB_21752829_ChIP-Seq_HELA_Human1.25146018
117BCAT_22108803_ChIP-Seq_LS180_Human1.25073450
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22516032
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.21687318
120RUNX2_22187159_ChIP-Seq_PCA_Human1.21584131
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21562249
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21477268
123KDM5A_27292631_Chip-Seq_BREAST_Human1.20268231
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20261235
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19821550
126E2F1_18555785_Chip-Seq_ESCs_Mouse1.18577655
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18237058
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17380219
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.15749700
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.15507411
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15294790
132SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14813947
133FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14109854
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13893943
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.13760328
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13684745
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13505016
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13294392
139TP53_16413492_ChIP-PET_HCT116_Human1.12739295
140BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12090957
141SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12024392
142ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11343339
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10154550
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08835550
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08415461
146P300_18555785_Chip-Seq_ESCs_Mouse1.07633225
147E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07391653
148RNF2_27304074_Chip-Seq_NSC_Mouse1.07064264
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06949881
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06381670
151ELK1_22589737_ChIP-Seq_MCF10A_Human1.05266434
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04581515
153TAL1_26923725_Chip-Seq_HPCs_Mouse1.04540568
154SPI1_23547873_ChIP-Seq_NB4_Human1.04331448
155TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03918814
156SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03719120
157FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02188832
158MYC_18940864_ChIP-ChIP_HL60_Human1.01893622
159SOX2_21211035_ChIP-Seq_LN229_Gbm1.00573484
160NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00466226
161NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00466226
162KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00368904
163PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00016570
164TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99084669
165IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98992099
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98719995
167NOTCH1_21737748_ChIP-Seq_TLL_Human0.97426029
168PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95642347
169CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95063558
170YY1_21170310_ChIP-Seq_MESCs_Mouse0.94877251
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91574982
172SOX17_20123909_ChIP-Seq_XEN_Mouse0.90173700
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89088178
174HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86044093
175CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85318767
176CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84851432
177GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84479167
178CIITA_25753668_ChIP-Seq_RAJI_Human0.83072634
179NANOG_21062744_ChIP-ChIP_HESCs_Human0.80103947
180KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79851581
181TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79480825
182PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79448730
183EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78341849
184POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77873860
185NANOG_16153702_ChIP-ChIP_HESCs_Human0.74867968
186IRF8_22096565_ChIP-ChIP_GC-B_Human0.73952828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.86901812
2MP0010094_abnormal_chromosome_stability3.81077197
3MP0004957_abnormal_blastocyst_morpholog3.62064251
4MP0003077_abnormal_cell_cycle3.44985440
5MP0003111_abnormal_nucleus_morphology3.37741295
6MP0000569_abnormal_digit_pigmentation3.07938424
7MP0008057_abnormal_DNA_replication2.99934160
8MP0008007_abnormal_cellular_replicative2.93743764
9MP0008058_abnormal_DNA_repair2.70128034
10MP0004043_abnormal_pH_regulation2.60197476
11MP0003136_yellow_coat_color2.58821556
12MP0003880_abnormal_central_pattern2.54870474
13MP0003718_maternal_effect2.47734770
14MP0008932_abnormal_embryonic_tissue2.34120411
15MP0002234_abnormal_pharynx_morphology2.32202107
16MP0001529_abnormal_vocalization2.28586140
17MP0010352_gastrointestinal_tract_polyps2.25542889
18MP0010307_abnormal_tumor_latency2.03893057
19MP0000631_abnormal_neuroendocrine_gland1.95141243
20MP0000350_abnormal_cell_proliferation1.92527772
21MP0003123_paternal_imprinting1.91123544
22MP0003787_abnormal_imprinting1.90531742
23MP0000427_abnormal_hair_cycle1.88059760
24MP0000778_abnormal_nervous_system1.87403588
25MP0001968_abnormal_touch/_nociception1.85339073
26MP0002751_abnormal_autonomic_nervous1.84493399
27MP0001730_embryonic_growth_arrest1.83869877
28MP0005084_abnormal_gallbladder_morpholo1.79805434
29MP0005551_abnormal_eye_electrophysiolog1.76310174
30MP0003195_calcinosis1.76172603
31MP0002736_abnormal_nociception_after1.76096036
32MP0001984_abnormal_olfaction1.73783566
33MP0005253_abnormal_eye_physiology1.68606306
34MP0009046_muscle_twitch1.68594335
35MP0003122_maternal_imprinting1.68299853
36MP0006072_abnormal_retinal_apoptosis1.62478557
37MP0004484_altered_response_of1.60187485
38MP0009745_abnormal_behavioral_response1.59997649
39MP0004885_abnormal_endolymph1.56871382
40MP0002396_abnormal_hematopoietic_system1.56333179
41MP0001486_abnormal_startle_reflex1.54024337
42MP0002095_abnormal_skin_pigmentation1.53836229
43MP0010030_abnormal_orbit_morphology1.53512003
44MP0002233_abnormal_nose_morphology1.52636650
45MP0006276_abnormal_autonomic_nervous1.52029756
46MP0000049_abnormal_middle_ear1.47881999
47MP0001485_abnormal_pinna_reflex1.47468456
48MP0003786_premature_aging1.44085924
49MP0001545_abnormal_hematopoietic_system1.44001885
50MP0005397_hematopoietic_system_phenotyp1.44001885
51MP0009333_abnormal_splenocyte_physiolog1.44000403
52MP0002272_abnormal_nervous_system1.43719182
53MP0001697_abnormal_embryo_size1.42192270
54MP0008877_abnormal_DNA_methylation1.42134397
55MP0005367_renal/urinary_system_phenotyp1.41535408
56MP0000516_abnormal_urinary_system1.41535408
57MP0006292_abnormal_olfactory_placode1.38001880
58MP0001672_abnormal_embryogenesis/_devel1.37373512
59MP0005380_embryogenesis_phenotype1.37373512
60MP0008789_abnormal_olfactory_epithelium1.37203254
61MP0003315_abnormal_perineum_morphology1.36328276
62MP0005187_abnormal_penis_morphology1.35505189
63MP0005645_abnormal_hypothalamus_physiol1.35290725
64MP0005076_abnormal_cell_differentiation1.34350126
65MP0002638_abnormal_pupillary_reflex1.34208040
66MP0004142_abnormal_muscle_tone1.32450930
67MP0002102_abnormal_ear_morphology1.32316780
68MP0003941_abnormal_skin_development1.32243540
69MP0000490_abnormal_crypts_of1.30027837
70MP0010234_abnormal_vibrissa_follicle1.28986254
71MP0006054_spinal_hemorrhage1.27244608
72MP0008872_abnormal_physiological_respon1.25141651
73MP0004133_heterotaxia1.24983125
74MP0002085_abnormal_embryonic_tissue1.24439475
75MP0000372_irregular_coat_pigmentation1.23706781
76MP0002837_dystrophic_cardiac_calcinosis1.22711845
77MP0002572_abnormal_emotion/affect_behav1.22371611
78MP0001835_abnormal_antigen_presentation1.20769489
79MP0003890_abnormal_embryonic-extraembry1.20614888
80MP0003646_muscle_fatigue1.20456795
81MP0002084_abnormal_developmental_patter1.19177330
82MP0010386_abnormal_urinary_bladder1.16858561
83MP0002928_abnormal_bile_duct1.15610903
84MP0004147_increased_porphyrin_level1.15271751
85MP0002019_abnormal_tumor_incidence1.14366814
86MP0003984_embryonic_growth_retardation1.13307959
87MP0002086_abnormal_extraembryonic_tissu1.12869519
88MP0000313_abnormal_cell_death1.11735114
89MP0002088_abnormal_embryonic_growth/wei1.09535968
90MP0002733_abnormal_thermal_nociception1.09382074
91MP0005386_behavior/neurological_phenoty1.09330784
92MP0004924_abnormal_behavior1.09330784
93MP0005174_abnormal_tail_pigmentation1.08866095
94MP0002080_prenatal_lethality1.08123676
95MP0001119_abnormal_female_reproductive1.08102417
96MP0005646_abnormal_pituitary_gland1.07733311
97MP0001764_abnormal_homeostasis1.07348299
98MP0004197_abnormal_fetal_growth/weight/1.06643473
99MP0000613_abnormal_salivary_gland1.04879536
100MP0002067_abnormal_sensory_capabilities1.04150591
101MP0004808_abnormal_hematopoietic_stem1.03765922
102MP0002734_abnormal_mechanical_nocicepti1.03702634
103MP0003121_genomic_imprinting1.03671736
104MP0001970_abnormal_pain_threshold1.02777683
105MP0001986_abnormal_taste_sensitivity1.02450101
106MP0002064_seizures1.01933559
107MP0001346_abnormal_lacrimal_gland1.01829550
108MP0002184_abnormal_innervation1.01575281
109MP0002877_abnormal_melanocyte_morpholog1.01034375
110MP0008995_early_reproductive_senescence0.99794188
111MP0001324_abnormal_eye_pigmentation0.98984423
112MP0000858_altered_metastatic_potential0.98932069
113MP0002063_abnormal_learning/memory/cond0.97988501
114MP0003448_altered_tumor_morphology0.97888500
115MP0003186_abnormal_redox_activity0.96423965
116MP0003937_abnormal_limbs/digits/tail_de0.96177619
117MP0002752_abnormal_somatic_nervous0.95241099
118MP0001188_hyperpigmentation0.95045574
119MP0003635_abnormal_synaptic_transmissio0.94537089
120MP0002210_abnormal_sex_determination0.94512219
121MP0001853_heart_inflammation0.93632208
122MP0002148_abnormal_hypersensitivity_rea0.92986798
123MP0005408_hypopigmentation0.92930496
124MP0009785_altered_susceptibility_to0.91938324
125MP0005499_abnormal_olfactory_system0.91514510
126MP0005394_taste/olfaction_phenotype0.91514510
127MP0008875_abnormal_xenobiotic_pharmacok0.89793373
128MP0006035_abnormal_mitochondrial_morpho0.89569647
129MP0003453_abnormal_keratinocyte_physiol0.89325198
130MP0001177_atelectasis0.87935274
131MP0002557_abnormal_social/conspecific_i0.87798701
132MP0000566_synostosis0.87737226
133MP0005391_vision/eye_phenotype0.87646643
134MP0003119_abnormal_digestive_system0.87516024
135MP0002277_abnormal_respiratory_mucosa0.86966484
136MP0002735_abnormal_chemical_nociception0.86456257
137MP0001293_anophthalmia0.86127107
138MP0004742_abnormal_vestibular_system0.85526953
139MP0004811_abnormal_neuron_physiology0.85148736
140MP0005195_abnormal_posterior_eye0.84525482
141MP0002653_abnormal_ependyma_morphology0.84127862
142MP0002282_abnormal_trachea_morphology0.83791806
143MP0005257_abnormal_intraocular_pressure0.83668569
144MP0003705_abnormal_hypodermis_morpholog0.83563535
145MP0005171_absent_coat_pigmentation0.83186136
146MP0005621_abnormal_cell_physiology0.82415010
147MP0002882_abnormal_neuron_morphology0.82405826
148MP0003698_abnormal_male_reproductive0.81548818
149MP0009697_abnormal_copulation0.81371295
150MP0002398_abnormal_bone_marrow0.80545203
151MP0000627_abnormal_mammary_gland0.80540840
152MP0001915_intracranial_hemorrhage0.80480301
153MP0002938_white_spotting0.80278900
154MP0001929_abnormal_gametogenesis0.80114215
155MP0003567_abnormal_fetal_cardiomyocyte0.79292935
156MP0002109_abnormal_limb_morphology0.78820391
157MP0002163_abnormal_gland_morphology0.78072268
158MP0002452_abnormal_antigen_presenting0.77881361
159MP0003436_decreased_susceptibility_to0.77722869
160MP0005395_other_phenotype0.76090756
161MP0010678_abnormal_skin_adnexa0.76056544
162MP0000383_abnormal_hair_follicle0.75694957
163MP0003763_abnormal_thymus_physiology0.74641440
164MP0009053_abnormal_anal_canal0.74004575
165MP0002405_respiratory_system_inflammati0.73554868
166MP0003755_abnormal_palate_morphology0.73514057
167MP0001145_abnormal_male_reproductive0.73483352
168MP0000647_abnormal_sebaceous_gland0.72915575
169MP0000653_abnormal_sex_gland0.72681980
170MP0001286_abnormal_eye_development0.72524038
171MP0002722_abnormal_immune_system0.72497926
172MP0002098_abnormal_vibrissa_morphology0.71817588
173MP0000703_abnormal_thymus_morphology0.71524823
174MP0003566_abnormal_cell_adhesion0.70636658
175MP0001216_abnormal_epidermal_layer0.70596691
176MP0005384_cellular_phenotype0.70044293
177MP0005023_abnormal_wound_healing0.69849564
178MP0000689_abnormal_spleen_morphology0.69751494
179MP0000377_abnormal_hair_follicle0.69746734
180MP0005000_abnormal_immune_tolerance0.69411441
181MP0002111_abnormal_tail_morphology0.69138849

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.58241298
2Chromsome breakage (HP:0040012)4.00144729
3Pancreatic cysts (HP:0001737)3.97495076
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84670974
5Broad-based gait (HP:0002136)3.76390890
6True hermaphroditism (HP:0010459)3.69771191
7Pancreatic fibrosis (HP:0100732)3.68404569
8Hyperventilation (HP:0002883)3.45942586
9Progressive inability to walk (HP:0002505)3.31811589
10Molar tooth sign on MRI (HP:0002419)3.27940321
11Abnormality of midbrain morphology (HP:0002418)3.27940321
12Nephronophthisis (HP:0000090)3.26858995
13Breast hypoplasia (HP:0003187)3.23858450
14Long nose (HP:0003189)3.23472636
15Type II lissencephaly (HP:0007260)3.19586168
16Patellar aplasia (HP:0006443)3.14951284
17Abnormality of chromosome stability (HP:0003220)3.14937945
18Medial flaring of the eyebrow (HP:0010747)3.08652354
19Meckel diverticulum (HP:0002245)3.00550021
20Reticulocytopenia (HP:0001896)2.99707669
21Aplasia/Hypoplasia of the patella (HP:0006498)2.96610302
22Lissencephaly (HP:0001339)2.94844542
23Abnormality of the preputium (HP:0100587)2.93535401
24Inability to walk (HP:0002540)2.91003657
25Absent radius (HP:0003974)2.89699528
26Carpal bone hypoplasia (HP:0001498)2.84246637
27Abnormality of the renal medulla (HP:0100957)2.84034095
28Abnormality of the ileum (HP:0001549)2.80893777
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.78952857
30Abolished electroretinogram (ERG) (HP:0000550)2.69137352
31Aplasia involving forearm bones (HP:0009822)2.68716424
32Absent forearm bone (HP:0003953)2.68716424
33Abnormality of the anterior horn cell (HP:0006802)2.66602986
34Degeneration of anterior horn cells (HP:0002398)2.66602986
35Aplastic anemia (HP:0001915)2.66376665
36Supernumerary spleens (HP:0009799)2.64288479
37Agnosia (HP:0010524)2.64176237
38Reduced antithrombin III activity (HP:0001976)2.61536759
39Neoplasm of the oral cavity (HP:0100649)2.60003961
40Type I transferrin isoform profile (HP:0003642)2.59153210
41Abnormality of the renal cortex (HP:0011035)2.58841032
42Myelodysplasia (HP:0002863)2.57254814
43Conical tooth (HP:0000698)2.56563677
44Absent thumb (HP:0009777)2.54175011
45Duodenal stenosis (HP:0100867)2.47791236
46Small intestinal stenosis (HP:0012848)2.47791236
47Prostate neoplasm (HP:0100787)2.47686851
48Impulsivity (HP:0100710)2.47564515
49Gait imbalance (HP:0002141)2.45976807
50Disinhibition (HP:0000734)2.45757345
51Genital tract atresia (HP:0001827)2.45030946
52Congenital primary aphakia (HP:0007707)2.44373533
53Selective tooth agenesis (HP:0001592)2.44328271
54Ectopic kidney (HP:0000086)2.43130916
55Renal cortical cysts (HP:0000803)2.41821705
56Nephrogenic diabetes insipidus (HP:0009806)2.40622275
57Colon cancer (HP:0003003)2.38684460
58Abnormality of the labia minora (HP:0012880)2.37409536
59Bilateral microphthalmos (HP:0007633)2.37184102
60Vaginal atresia (HP:0000148)2.34345009
61Attenuation of retinal blood vessels (HP:0007843)2.33605204
62Abnormality of DNA repair (HP:0003254)2.32661436
63Pallor (HP:0000980)2.31038182
64Oral leukoplakia (HP:0002745)2.29970345
65Pachygyria (HP:0001302)2.28736123
66Congenital stationary night blindness (HP:0007642)2.27766605
67Cerebellar dysplasia (HP:0007033)2.26028909
68Postaxial foot polydactyly (HP:0001830)2.22763057
69Gaze-evoked nystagmus (HP:0000640)2.22315901
70Abnormal lung lobation (HP:0002101)2.21622889
71Premature graying of hair (HP:0002216)2.20905680
72Chronic hepatic failure (HP:0100626)2.20363463
73Cystic liver disease (HP:0006706)2.20211573
74Stenosis of the external auditory canal (HP:0000402)2.19418390
75Bone marrow hypocellularity (HP:0005528)2.18151384
76Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17480003
77Abnormal protein glycosylation (HP:0012346)2.17327773
78Abnormal glycosylation (HP:0012345)2.17327773
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17327773
80Abnormal protein N-linked glycosylation (HP:0012347)2.17327773
81Adrenal hypoplasia (HP:0000835)2.16405671
82Hyperglycinemia (HP:0002154)2.15447722
83Febrile seizures (HP:0002373)2.15417321
84Cutaneous melanoma (HP:0012056)2.14411542
85Drooling (HP:0002307)2.12930197
86Intestinal atresia (HP:0011100)2.12188220
87Absent speech (HP:0001344)2.10850223
88Focal motor seizures (HP:0011153)2.10377191
89Postaxial hand polydactyly (HP:0001162)2.09821271
90Aplasia/Hypoplasia of the tongue (HP:0010295)2.09093112
91Aplasia/Hypoplasia of the tibia (HP:0005772)2.07963304
92Triphalangeal thumb (HP:0001199)2.07716058
93Retinal dysplasia (HP:0007973)2.07485661
94Medulloblastoma (HP:0002885)2.05494550
95Duplicated collecting system (HP:0000081)2.04340329
96Entropion (HP:0000621)2.04285456
97Preaxial foot polydactyly (HP:0001841)2.03299057
98Capillary hemangiomas (HP:0005306)2.02461531
99Rough bone trabeculation (HP:0100670)2.02190507
100Sloping forehead (HP:0000340)2.01760945
101Widely spaced teeth (HP:0000687)2.00715900
102Absent/shortened dynein arms (HP:0200106)2.00576496
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.00576496
104Abnormality of the duodenum (HP:0002246)1.98171729
105Bulbous nose (HP:0000414)1.97464937
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97046791
107Abnormality of alanine metabolism (HP:0010916)1.97046791
108Hyperalaninemia (HP:0003348)1.97046791
109Abnormality of macular pigmentation (HP:0008002)1.96820118
110Polyphagia (HP:0002591)1.95223567
111Amyotrophic lateral sclerosis (HP:0007354)1.94705212
112Excessive salivation (HP:0003781)1.94324720
113Methylmalonic acidemia (HP:0002912)1.94209430
114Irregular epiphyses (HP:0010582)1.92800172
115Blepharitis (HP:0000498)1.90738496
116Neoplasm of the pancreas (HP:0002894)1.90404817
117Anencephaly (HP:0002323)1.89128620
118Acute necrotizing encephalopathy (HP:0006965)1.89045176
119Congenital hepatic fibrosis (HP:0002612)1.88582965
120Short thumb (HP:0009778)1.88328549
121Shawl scrotum (HP:0000049)1.86506099
122Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86340432
123Small hand (HP:0200055)1.84507366
124Horseshoe kidney (HP:0000085)1.82875890
125Tracheoesophageal fistula (HP:0002575)1.82539831
126Nephroblastoma (Wilms tumor) (HP:0002667)1.82130687
127Clubbing of toes (HP:0100760)1.81670076
128Sclerocornea (HP:0000647)1.81539902
129Short middle phalanx of the 5th finger (HP:0004220)1.80397519
130Microretrognathia (HP:0000308)1.80282920
131Median cleft lip (HP:0000161)1.78689105
132Acute myeloid leukemia (HP:0004808)1.78388351
133Embryonal renal neoplasm (HP:0011794)1.78216890
134Abnormality of the renal collecting system (HP:0004742)1.78153108
135Stomach cancer (HP:0012126)1.77728622
136Absent eyebrow (HP:0002223)1.77422216
137Constricted visual fields (HP:0001133)1.77421677
138Optic nerve hypoplasia (HP:0000609)1.77192721
139Fair hair (HP:0002286)1.77092135
140Recurrent abscess formation (HP:0002722)1.76746679
141Slender long bone (HP:0003100)1.76180823
142Fused cervical vertebrae (HP:0002949)1.75990101
143Abnormal rod and cone electroretinograms (HP:0008323)1.75897232
144Cleft eyelid (HP:0000625)1.75891112
145Flat capital femoral epiphysis (HP:0003370)1.74580076
146Specific learning disability (HP:0001328)1.74545289
147Amaurosis fugax (HP:0100576)1.74089338
148Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73573094
149Short 4th metacarpal (HP:0010044)1.73573094
150Bifid tongue (HP:0010297)1.73009526
151Dandy-Walker malformation (HP:0001305)1.72925008
152Short tibia (HP:0005736)1.72774110
153Trismus (HP:0000211)1.72444252
154Abnormal trabecular bone morphology (HP:0100671)1.72299813
155Pulmonary fibrosis (HP:0002206)1.72021587
156Facial hemangioma (HP:0000329)1.71967990
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71410637
158Atonic seizures (HP:0010819)1.71302719
159Poor coordination (HP:0002370)1.71189605
160Atresia of the external auditory canal (HP:0000413)1.70983217
161Progressive macrocephaly (HP:0004481)1.70536029
162Secondary amenorrhea (HP:0000869)1.70117708
163Abnormal biliary tract physiology (HP:0012439)1.69781022
164Bile duct proliferation (HP:0001408)1.69781022
165Acute encephalopathy (HP:0006846)1.69347552
166Male pseudohermaphroditism (HP:0000037)1.68607423
167Tubular atrophy (HP:0000092)1.68578059
168Prominent nasal bridge (HP:0000426)1.67816338
169Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.67648407
170Breast aplasia (HP:0100783)1.66536203
171Abnormality of the pons (HP:0007361)1.66487482
172Squamous cell carcinoma (HP:0002860)1.65790929
173Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65507318
174Sparse eyelashes (HP:0000653)1.64736674
175Premature ovarian failure (HP:0008209)1.64518253
176Poor head control (HP:0002421)1.63564597
177Type 2 muscle fiber atrophy (HP:0003554)1.62249241
178Muscle fiber atrophy (HP:0100295)1.61588965
179Sparse lateral eyebrow (HP:0005338)1.60439468
180Personality changes (HP:0000751)1.59466123
181Malignant gastrointestinal tract tumors (HP:0006749)1.58862698
182Gastrointestinal carcinoma (HP:0002672)1.58862698
183Aseptic necrosis (HP:0010885)1.58569408
184Abnormality of the umbilical cord (HP:0010881)1.56711320
185Arteriovenous malformation (HP:0100026)1.56495754
186Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.56168459
187Deviation of the thumb (HP:0009603)1.55800377
188Abnormality of cells of the erythroid lineage (HP:0012130)1.55629661
189Abnormality of abdominal situs (HP:0011620)1.54630376
190Abdominal situs inversus (HP:0003363)1.54630376
191Volvulus (HP:0002580)1.53823600
192Aplasia/Hypoplasia involving the musculature (HP:0001460)1.53284398
193Natal tooth (HP:0000695)1.52679059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.79735226
2BUB13.74321882
3PBK3.73675350
4TAOK33.45580480
5WEE13.27578196
6MAP4K23.14639687
7NUAK12.95745742
8WNK32.88120605
9CDC72.85466361
10BRSK22.75238666
11TNIK2.74995818
12PLK42.66457830
13SRPK12.48582794
14EIF2AK32.35839313
15ACVR1B2.13180544
16PINK12.09652704
17PLK12.02824853
18CASK2.02175054
19NME22.01973594
20MKNK12.01540336
21TTK1.98558646
22NEK21.97412661
23ADRBK21.88885876
24RPS6KA41.82307345
25PLK31.81728854
26ZAK1.76924278
27TRIM281.75777864
28FRK1.72167453
29MAPK131.71713797
30GRK11.68654939
31TIE11.65144815
32MKNK21.64559448
33AURKB1.58814349
34STK101.56184339
35ERBB31.51767058
36MAP3K41.50427532
37VRK11.48580141
38MST41.46512305
39LATS11.44966065
40TGFBR21.44324735
41CHEK21.41947874
42PIM21.41200806
43CDK71.39465786
44EIF2AK21.37452361
45STK31.36724176
46STK38L1.35775978
47MAP3K81.30582469
48NEK11.28330098
49RPS6KB21.28158309
50DYRK31.27788457
51ATR1.27575046
52BRSK11.25762988
53TESK21.23998061
54MELK1.23175932
55EPHA41.22873103
56MARK11.19689855
57STK161.18537504
58BRAF1.18236919
59OXSR11.14747979
60CSNK1G21.14519452
61INSRR1.11648099
62NEK91.10811362
63PNCK1.10783101
64STK41.10423811
65CSNK1G11.05099077
66CSNK1G31.04980559
67BCKDK1.04182015
68AURKA1.03635684
69EPHA31.03262441
70CDK81.01682636
71CSNK1A1L1.00455864
72ERBB41.00112457
73PAK30.98669616
74EPHA20.97074517
75PIM10.96825472
76CDC42BPA0.94064100
77LATS20.92253796
78MAP3K140.91061997
79STK390.88962642
80CHUK0.88749106
81BRD40.88466272
82CHEK10.87639440
83TGFBR10.85642680
84IKBKB0.85330190
85PRKCE0.84324367
86ATM0.84172068
87MAP2K70.83226544
88PASK0.82267583
89ADRBK10.81527102
90CDK60.81301888
91TLK10.81192316
92DYRK20.79671260
93CAMKK20.78332201
94CDK190.77758524
95CAMK2A0.76355384
96CDK40.70688347
97TRPM70.70169765
98PRKCG0.70134079
99ABL20.69616523
100BLK0.67388535
101MOS0.67281258
102IRAK10.66799655
103SGK20.65256845
104MAP3K50.65183420
105MAPKAPK30.63992840
106NLK0.63861368
107TESK10.61526258
108WNK10.60999551
109CDK20.59146948
110BCR0.59024074
111WNK40.58688745
112DMPK0.58557400
113JAK30.58102824
114NTRK20.57040294
115YES10.56878685
116CSNK2A10.56396582
117TSSK60.56127817
118BMPR20.55560562
119CDK30.55034527
120MARK30.54994785
121KIT0.54476754
122RAF10.53845390
123HCK0.53281398
124MAPK150.51018226
125DAPK20.49986733
126CDK10.49600990
127TXK0.49037907
128CCNB10.48730363
129RPS6KA50.48174303
130STK110.48038572
131PRKCI0.46804052
132CDK120.43760041
133LIMK10.43745926
134ARAF0.42720077
135PIK3CA0.42374927
136PAK40.41391140
137CSNK2A20.39882983
138LCK0.39776980
139ABL10.39352730
140FER0.39279489
141MAP2K40.38889006
142PAK10.37975927
143AKT30.37556194
144PTK2B0.37424624
145ERBB20.37297796
146MINK10.37108505
147TEC0.36842904
148PKN10.36430703
149PRKCQ0.36163744
150PLK20.35988698
151FLT30.35682253
152SCYL20.35330074
153MATK0.35086881
154SGK4940.34857803
155SGK2230.34857803
156LRRK20.34697534
157NTRK30.34167768
158CSNK1A10.33949190
159TAOK20.33544058
160PRKACA0.32058358
161MAP3K120.31537462
162MAP3K30.31220986
163DYRK1A0.31115603
164MUSK0.30936859
165BMPR1B0.25797610

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.31709407
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.77666029
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43218601
4DNA replication_Homo sapiens_hsa030303.34103898
5RNA polymerase_Homo sapiens_hsa030203.18822911
6Cell cycle_Homo sapiens_hsa041103.03331495
7Mismatch repair_Homo sapiens_hsa034303.00343750
8Homologous recombination_Homo sapiens_hsa034402.74799084
9Proteasome_Homo sapiens_hsa030502.73507136
10RNA transport_Homo sapiens_hsa030132.70447618
11Spliceosome_Homo sapiens_hsa030402.63116015
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43722456
13Phototransduction_Homo sapiens_hsa047442.38087653
14Nucleotide excision repair_Homo sapiens_hsa034202.37719720
15Propanoate metabolism_Homo sapiens_hsa006402.35404541
16Non-homologous end-joining_Homo sapiens_hsa034502.33625738
17Base excision repair_Homo sapiens_hsa034102.32946218
18Nicotine addiction_Homo sapiens_hsa050332.29995507
19Ribosome_Homo sapiens_hsa030102.22194377
20Fanconi anemia pathway_Homo sapiens_hsa034602.21783472
21p53 signaling pathway_Homo sapiens_hsa041152.17805146
22Basal transcription factors_Homo sapiens_hsa030222.16913473
23Regulation of autophagy_Homo sapiens_hsa041402.12470778
24RNA degradation_Homo sapiens_hsa030182.10015379
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08920224
26Pyrimidine metabolism_Homo sapiens_hsa002402.08640215
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91551014
28Oxidative phosphorylation_Homo sapiens_hsa001901.88473196
29Taste transduction_Homo sapiens_hsa047421.85312224
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77713067
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75193612
32One carbon pool by folate_Homo sapiens_hsa006701.73079115
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64841481
34Butanoate metabolism_Homo sapiens_hsa006501.61625940
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56293995
36Parkinsons disease_Homo sapiens_hsa050121.53795886
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49390300
38Nitrogen metabolism_Homo sapiens_hsa009101.45321423
39mRNA surveillance pathway_Homo sapiens_hsa030151.44527183
40Steroid biosynthesis_Homo sapiens_hsa001001.40611513
41Linoleic acid metabolism_Homo sapiens_hsa005911.40286433
42Epstein-Barr virus infection_Homo sapiens_hsa051691.38735163
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36024006
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35383606
45Morphine addiction_Homo sapiens_hsa050321.33804747
46Ether lipid metabolism_Homo sapiens_hsa005651.33412549
47Herpes simplex infection_Homo sapiens_hsa051681.32510367
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29718107
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21765746
50Selenocompound metabolism_Homo sapiens_hsa004501.21280190
51Glutamatergic synapse_Homo sapiens_hsa047241.20753433
52GABAergic synapse_Homo sapiens_hsa047271.20595899
53Olfactory transduction_Homo sapiens_hsa047401.19996513
54Peroxisome_Homo sapiens_hsa041461.17879953
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15549240
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14866435
57Purine metabolism_Homo sapiens_hsa002301.14043652
58Legionellosis_Homo sapiens_hsa051341.12783413
59Viral carcinogenesis_Homo sapiens_hsa052031.11525302
60TGF-beta signaling pathway_Homo sapiens_hsa043501.11386102
61Circadian entrainment_Homo sapiens_hsa047131.10589535
62Allograft rejection_Homo sapiens_hsa053301.09283490
63MicroRNAs in cancer_Homo sapiens_hsa052061.08959990
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08651064
65Caffeine metabolism_Homo sapiens_hsa002321.05280518
66Huntingtons disease_Homo sapiens_hsa050161.04341398
67NF-kappa B signaling pathway_Homo sapiens_hsa040641.03547529
68Dopaminergic synapse_Homo sapiens_hsa047281.01618561
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.97878474
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97663053
71Antigen processing and presentation_Homo sapiens_hsa046120.94843176
72Small cell lung cancer_Homo sapiens_hsa052220.94038220
73Alzheimers disease_Homo sapiens_hsa050100.93046621
74Systemic lupus erythematosus_Homo sapiens_hsa053220.90894286
75Measles_Homo sapiens_hsa051620.90869908
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90616630
77Apoptosis_Homo sapiens_hsa042100.89855461
78HTLV-I infection_Homo sapiens_hsa051660.89801736
79ABC transporters_Homo sapiens_hsa020100.89327057
80Oocyte meiosis_Homo sapiens_hsa041140.88787746
81Graft-versus-host disease_Homo sapiens_hsa053320.87909742
82Tryptophan metabolism_Homo sapiens_hsa003800.84814682
83Serotonergic synapse_Homo sapiens_hsa047260.84615594
84Axon guidance_Homo sapiens_hsa043600.83562531
85Shigellosis_Homo sapiens_hsa051310.80974611
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80621304
87Hepatitis B_Homo sapiens_hsa051610.80380670
88Protein export_Homo sapiens_hsa030600.76426474
89Leishmaniasis_Homo sapiens_hsa051400.76208414
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75163347
91Insulin secretion_Homo sapiens_hsa049110.74184889
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73762949
93Hippo signaling pathway_Homo sapiens_hsa043900.73305822
94Influenza A_Homo sapiens_hsa051640.72506880
95TNF signaling pathway_Homo sapiens_hsa046680.72394858
96Malaria_Homo sapiens_hsa051440.71564579
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71461981
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.69898548
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68882441
100Asthma_Homo sapiens_hsa053100.68230694
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68200221
102Hematopoietic cell lineage_Homo sapiens_hsa046400.68017435
103Thyroid cancer_Homo sapiens_hsa052160.66454301
104Colorectal cancer_Homo sapiens_hsa052100.65692863
105Pancreatic cancer_Homo sapiens_hsa052120.64829466
106Salivary secretion_Homo sapiens_hsa049700.63494877
107Chemical carcinogenesis_Homo sapiens_hsa052040.62979173
108Hedgehog signaling pathway_Homo sapiens_hsa043400.60268291
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59503140
110N-Glycan biosynthesis_Homo sapiens_hsa005100.59350748
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59062212
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58774733
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.57642499
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.57141493
115Adherens junction_Homo sapiens_hsa045200.57052659
116Collecting duct acid secretion_Homo sapiens_hsa049660.56953238
117Folate biosynthesis_Homo sapiens_hsa007900.56873227
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.56483718
119Viral myocarditis_Homo sapiens_hsa054160.56261231
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55975184
121Autoimmune thyroid disease_Homo sapiens_hsa053200.55300488
122Metabolic pathways_Homo sapiens_hsa011000.54653398
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54458790
124Phagosome_Homo sapiens_hsa041450.52319841
125Rheumatoid arthritis_Homo sapiens_hsa053230.51343027
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51011355
127Prostate cancer_Homo sapiens_hsa052150.50914159
128Calcium signaling pathway_Homo sapiens_hsa040200.50755871
129beta-Alanine metabolism_Homo sapiens_hsa004100.50639109
130Chronic myeloid leukemia_Homo sapiens_hsa052200.50202538
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.49881237
132Notch signaling pathway_Homo sapiens_hsa043300.49505886
133Amphetamine addiction_Homo sapiens_hsa050310.48739063
134Renin secretion_Homo sapiens_hsa049240.48702021
135Retinol metabolism_Homo sapiens_hsa008300.48607797
136Long-term depression_Homo sapiens_hsa047300.48578523
137Melanoma_Homo sapiens_hsa052180.48037398
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47409278
139Type I diabetes mellitus_Homo sapiens_hsa049400.46571358
140Vitamin B6 metabolism_Homo sapiens_hsa007500.45269177
141Other glycan degradation_Homo sapiens_hsa005110.45050731
142Cardiac muscle contraction_Homo sapiens_hsa042600.43452304
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42811253
144Toxoplasmosis_Homo sapiens_hsa051450.41344069
145Bladder cancer_Homo sapiens_hsa052190.40999690
146Pathways in cancer_Homo sapiens_hsa052000.40089469
147Tuberculosis_Homo sapiens_hsa051520.39220364
148Fatty acid metabolism_Homo sapiens_hsa012120.39203052
149Sphingolipid metabolism_Homo sapiens_hsa006000.39148303
150Basal cell carcinoma_Homo sapiens_hsa052170.38918633
151Fatty acid elongation_Homo sapiens_hsa000620.38568910
152Arachidonic acid metabolism_Homo sapiens_hsa005900.38018851
153FoxO signaling pathway_Homo sapiens_hsa040680.35885931
154Dorso-ventral axis formation_Homo sapiens_hsa043200.35799084
155Sulfur metabolism_Homo sapiens_hsa009200.34875518
156Cholinergic synapse_Homo sapiens_hsa047250.33630384
157cAMP signaling pathway_Homo sapiens_hsa040240.33123060
158Salmonella infection_Homo sapiens_hsa051320.32718117
159Cocaine addiction_Homo sapiens_hsa050300.31976227
160Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30750943
161Primary immunodeficiency_Homo sapiens_hsa053400.30414148
162Endometrial cancer_Homo sapiens_hsa052130.30068482
163Hepatitis C_Homo sapiens_hsa051600.28953337
164Pertussis_Homo sapiens_hsa051330.28873998
165Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28368786
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.27504091
167Ovarian steroidogenesis_Homo sapiens_hsa049130.27364120
168HIF-1 signaling pathway_Homo sapiens_hsa040660.27112629
169Acute myeloid leukemia_Homo sapiens_hsa052210.27001676
170Pentose phosphate pathway_Homo sapiens_hsa000300.26847610
171Proteoglycans in cancer_Homo sapiens_hsa052050.25432411
172Osteoclast differentiation_Homo sapiens_hsa043800.25321359
173Circadian rhythm_Homo sapiens_hsa047100.25284846
174Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24887585

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