KBTBD11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.74161904
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.74161904
3locomotory exploration behavior (GO:0035641)5.46111833
4synaptic vesicle maturation (GO:0016188)5.12836273
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06827653
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05858890
7postsynaptic membrane organization (GO:0001941)4.66647766
8vocalization behavior (GO:0071625)4.63336650
9axon ensheathment in central nervous system (GO:0032291)4.62909174
10central nervous system myelination (GO:0022010)4.62909174
11cerebellar granule cell differentiation (GO:0021707)4.58278218
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48631135
13negative T cell selection (GO:0043383)4.43632483
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.35120983
15negative thymic T cell selection (GO:0045060)4.32375328
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30868126
17synaptic vesicle exocytosis (GO:0016079)4.29246265
18sodium ion export (GO:0071436)4.28396418
19regulation of glutamate receptor signaling pathway (GO:1900449)4.27216847
20amino acid import (GO:0043090)4.21875194
21cellular potassium ion homeostasis (GO:0030007)4.21549427
22potassium ion homeostasis (GO:0055075)4.13126394
23glutamate secretion (GO:0014047)4.08822623
24positive T cell selection (GO:0043368)3.99857436
25presynaptic membrane organization (GO:0097090)3.98551758
26exploration behavior (GO:0035640)3.97650932
27regulation of synaptic vesicle exocytosis (GO:2000300)3.89302890
28regulation of neuronal synaptic plasticity (GO:0048168)3.87308360
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.87184375
30presynaptic membrane assembly (GO:0097105)3.85807886
31long-term memory (GO:0007616)3.84492193
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82776230
33glutamate receptor signaling pathway (GO:0007215)3.80942841
34neuronal ion channel clustering (GO:0045161)3.79528144
35protein localization to synapse (GO:0035418)3.75321153
36T cell selection (GO:0045058)3.70116838
37synaptic transmission, glutamatergic (GO:0035249)3.67704575
38thymic T cell selection (GO:0045061)3.64986913
39neuronal action potential propagation (GO:0019227)3.64035376
40regulation of neurotransmitter levels (GO:0001505)3.62700230
41positive regulation of dendritic spine development (GO:0060999)3.59092000
42regulation of neurotransmitter secretion (GO:0046928)3.58734862
43negative regulation of dendrite morphogenesis (GO:0050774)3.53805570
44cerebellar Purkinje cell differentiation (GO:0021702)3.53104883
45neurotransmitter secretion (GO:0007269)3.52992183
46regulation of ARF protein signal transduction (GO:0032012)3.52310636
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47613613
48regulation of synaptic vesicle transport (GO:1902803)3.44850120
49response to interleukin-15 (GO:0070672)3.44440222
50positive thymic T cell selection (GO:0045059)3.43625068
51regulation of synapse structural plasticity (GO:0051823)3.42768728
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42527898
53regulation of synapse maturation (GO:0090128)3.41690112
54layer formation in cerebral cortex (GO:0021819)3.40983842
55long-term synaptic potentiation (GO:0060291)3.38812019
56neurotransmitter-gated ion channel clustering (GO:0072578)3.37148262
57neuron-neuron synaptic transmission (GO:0007270)3.36607241
58regulation of isotype switching to IgG isotypes (GO:0048302)3.36387061
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.35951075
60establishment of mitochondrion localization (GO:0051654)3.35861528
61dendritic spine morphogenesis (GO:0060997)3.35677399
62auditory behavior (GO:0031223)3.35330150
63positive regulation of membrane potential (GO:0045838)3.31720129
64regulation of synaptic plasticity (GO:0048167)3.31632709
65neuron cell-cell adhesion (GO:0007158)3.30023116
66cellular response to interleukin-15 (GO:0071350)3.29589186
67neuron recognition (GO:0008038)3.26726739
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26494994
69cell migration in hindbrain (GO:0021535)3.22116914
70regulation of voltage-gated calcium channel activity (GO:1901385)3.21643277
71regulation of postsynaptic membrane potential (GO:0060078)3.19131400
72neurotransmitter uptake (GO:0001504)3.18193275
73regulation of neurotransmitter transport (GO:0051588)3.18023476
74axonal fasciculation (GO:0007413)3.16775427
75membrane depolarization during action potential (GO:0086010)3.15206719
76activation of protein kinase A activity (GO:0034199)3.14139294
77signal complex assembly (GO:0007172)3.14033042
78regulation of vesicle fusion (GO:0031338)3.13583901
79regulation of dendritic spine morphogenesis (GO:0061001)3.12061555
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.11419974
81positive regulation of synapse maturation (GO:0090129)3.09782527
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09278283
83acidic amino acid transport (GO:0015800)3.05412913
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04592283
85response to auditory stimulus (GO:0010996)3.04461085
86gamma-aminobutyric acid transport (GO:0015812)3.02868257
87gamma-aminobutyric acid signaling pathway (GO:0007214)3.02699626
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02408762
89regulation of Rap GTPase activity (GO:0032317)3.01825262
90proline transport (GO:0015824)3.01003976
91neuromuscular process (GO:0050905)2.99881651
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98132213
93glycosphingolipid biosynthetic process (GO:0006688)2.97168782
94cellular sodium ion homeostasis (GO:0006883)2.96740915
95interferon-gamma production (GO:0032609)2.96473013
96regulation of dendritic spine development (GO:0060998)2.95768864
97response to histamine (GO:0034776)2.95483654
98adult walking behavior (GO:0007628)2.94945696
99transmission of nerve impulse (GO:0019226)2.94299465
100neuromuscular process controlling balance (GO:0050885)2.94289986
101behavioral defense response (GO:0002209)2.93539968
102behavioral fear response (GO:0001662)2.93539968
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93449114
104positive regulation of gamma-delta T cell activation (GO:0046645)2.93150318
105mating behavior (GO:0007617)2.91675339
106activated T cell proliferation (GO:0050798)2.91480294
107startle response (GO:0001964)2.91456408
108regulation of regulatory T cell differentiation (GO:0045589)2.91159380
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90233857
110potassium ion import (GO:0010107)2.90024128
111mechanosensory behavior (GO:0007638)2.89582472
112regulation of synaptic transmission (GO:0050804)2.88580460
113nerve growth factor signaling pathway (GO:0038180)2.87527882
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.86819658
115mitochondrion transport along microtubule (GO:0047497)2.86819658
116synaptic vesicle endocytosis (GO:0048488)2.86497410
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85893507
118cell differentiation in hindbrain (GO:0021533)2.84450852
119positive regulation of Rap GTPase activity (GO:0032854)2.84008865
120prepulse inhibition (GO:0060134)2.83951688
121mast cell degranulation (GO:0043303)2.83249689
122mast cell activation involved in immune response (GO:0002279)2.83249689
123establishment of nucleus localization (GO:0040023)2.83214304
124G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.82208145
125T cell receptor signaling pathway (GO:0050852)2.82131963
126regulation of gamma-delta T cell differentiation (GO:0045586)2.80611381
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79834710
128innervation (GO:0060384)2.79218796
129L-amino acid import (GO:0043092)2.79141204
130regulation of synaptic transmission, glutamatergic (GO:0051966)2.79082816
131neurotransmitter transport (GO:0006836)2.77548886
132negative regulation of synaptic transmission, GABAergic (GO:0032229)2.76328818
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.74135931
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70951566
135cell communication by electrical coupling (GO:0010644)2.68461564
136membrane depolarization (GO:0051899)2.68297012
137fear response (GO:0042596)2.67493565
138vesicle transport along microtubule (GO:0047496)2.67093908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92714482
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.40928352
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24779456
4DROSHA_22980978_ChIP-Seq_HELA_Human2.94135489
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.93546351
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.73817062
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60911308
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56575517
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47982453
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.47888417
11REST_21632747_ChIP-Seq_MESCs_Mouse2.44415842
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29986146
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29986146
14GBX2_23144817_ChIP-Seq_PC3_Human2.19637096
15RUNX_20019798_ChIP-Seq_JUKART_Human2.15406550
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14537532
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12290033
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09475474
19AR_21572438_ChIP-Seq_LNCaP_Human2.08222186
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08194794
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05293094
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04595269
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.99646700
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.93347919
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93119977
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92393090
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89829566
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87120426
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80404103
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.78547181
31* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78356835
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74720012
33* KDM2B_26808549_Chip-Seq_DND41_Human1.68537950
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65548124
35* EZH2_27304074_Chip-Seq_ESCs_Mouse1.64298616
36KDM2B_26808549_Chip-Seq_JURKAT_Human1.54474504
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53838515
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52152506
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50755417
40GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49788043
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49666528
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45970129
43KDM2B_26808549_Chip-Seq_K562_Human1.45510303
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.44335443
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.42335646
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42074983
47MYC_22102868_ChIP-Seq_BL_Human1.39043004
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38181738
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37889542
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34316979
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32803077
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30670633
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29077629
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27867810
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27434283
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26468983
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26276959
58SMAD4_21799915_ChIP-Seq_A2780_Human1.26226454
59* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25986021
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19574414
61TCF7_22412390_ChIP-Seq_EML_Mouse1.19445661
62* AR_19668381_ChIP-Seq_PC3_Human1.18185442
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17966585
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17420923
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16104731
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14762338
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14543924
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12292389
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.12176536
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10635581
71* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10019306
72* PRDM14_20953172_ChIP-Seq_ESCs_Human1.09286514
73* RNF2_27304074_Chip-Seq_NSC_Mouse1.08874158
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08036191
75RXR_22108803_ChIP-Seq_LS180_Human1.07672542
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06497124
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05762515
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.04846508
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04351143
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03950635
81STAT3_23295773_ChIP-Seq_U87_Human1.03695795
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00008009
83ARNT_22903824_ChIP-Seq_MCF-7_Human0.99686830
84AR_25329375_ChIP-Seq_VCAP_Human0.99595273
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99289408
86CTCF_27219007_Chip-Seq_Bcells_Human0.98955038
87TP53_16413492_ChIP-PET_HCT116_Human0.98705616
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98036291
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97826846
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.97447817
91MYB_26560356_Chip-Seq_TH2_Human0.96641203
92MAF_26560356_Chip-Seq_TH1_Human0.95799835
93AHR_22903824_ChIP-Seq_MCF-7_Human0.95630055
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95320096
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94856825
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94769501
97SPI1_23127762_ChIP-Seq_K562_Human0.94455411
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93827312
99UTX_26944678_Chip-Seq_JUKART_Human0.91158896
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90453178
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90133383
102TCF4_23295773_ChIP-Seq_U87_Human0.89817805
103* RING1B_27294783_Chip-Seq_NPCs_Mouse0.89684878
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89324688
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88937350
106SMAD3_21741376_ChIP-Seq_EPCs_Human0.88314473
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87959652
108LXR_22292898_ChIP-Seq_THP-1_Human0.87685188
109IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87612092
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87568204
111WDR5_24793694_ChIP-Seq_LNCAP_Human0.87351462
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.87206216
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.87049037
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.86659900
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86341417
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86341417
117TAF15_26573619_Chip-Seq_HEK293_Human0.85650386
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85256129
119P300_19829295_ChIP-Seq_ESCs_Human0.84985586
120DPY_21335234_ChIP-Seq_ESCs_Mouse0.84222544
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83224698
122TP53_20018659_ChIP-ChIP_R1E_Mouse0.83121321
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.82564803
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82518263
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82301163
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81335545
127GATA3_27048872_Chip-Seq_THYMUS_Human0.80580629
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.78445944
129KLF4_19829295_ChIP-Seq_ESCs_Human0.78372869
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77882110
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76205016
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76139638
133TRIM28_21343339_ChIP-Seq_HEK293_Human0.75992034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09367957
2MP0003880_abnormal_central_pattern4.18782265
3MP0003635_abnormal_synaptic_transmissio4.11105815
4MP0002822_catalepsy3.39258966
5MP0009745_abnormal_behavioral_response3.35557296
6MP0002063_abnormal_learning/memory/cond3.23408767
7MP0004270_analgesia3.08971154
8MP0002064_seizures2.99315961
9MP0005423_abnormal_somatic_nervous2.85239280
10MP0001968_abnormal_touch/_nociception2.80781540
11MP0002572_abnormal_emotion/affect_behav2.67186069
12MP0009046_muscle_twitch2.61434742
13MP0008569_lethality_at_weaning2.53505066
14MP0003763_abnormal_thymus_physiology2.45558268
15MP0002272_abnormal_nervous_system2.41836333
16MP0001486_abnormal_startle_reflex2.34833663
17MP0002735_abnormal_chemical_nociception2.31642383
18MP0001501_abnormal_sleep_pattern2.15014895
19MP0002736_abnormal_nociception_after2.13686485
20MP0003787_abnormal_imprinting2.04588423
21MP0002734_abnormal_mechanical_nocicepti1.94911231
22MP0008961_abnormal_basal_metabolism1.90737119
23MP0001440_abnormal_grooming_behavior1.88927044
24MP0004510_myositis1.79971106
25MP0002067_abnormal_sensory_capabilities1.76977926
26MP0001970_abnormal_pain_threshold1.70598131
27MP0003329_amyloid_beta_deposits1.69139609
28MP0004811_abnormal_neuron_physiology1.68940292
29MP0005386_behavior/neurological_phenoty1.61661022
30MP0004924_abnormal_behavior1.61661022
31MP0002733_abnormal_thermal_nociception1.61060218
32MP0002557_abnormal_social/conspecific_i1.59468843
33MP0009780_abnormal_chondrocyte_physiolo1.59436266
34MP0004885_abnormal_endolymph1.56988341
35MP0009379_abnormal_foot_pigmentation1.55482284
36MP0000778_abnormal_nervous_system1.52356994
37MP0003122_maternal_imprinting1.51983099
38MP0002184_abnormal_innervation1.50262845
39MP0003633_abnormal_nervous_system1.47999556
40MP0004858_abnormal_nervous_system1.45873435
41MP0010234_abnormal_vibrissa_follicle1.36119332
42MP0003866_abnormal_defecation1.35084378
43MP0000955_abnormal_spinal_cord1.34590937
44MP0002909_abnormal_adrenal_gland1.33210622
45MP0004147_increased_porphyrin_level1.28687332
46MP0002066_abnormal_motor_capabilities/c1.23625205
47MP0001502_abnormal_circadian_rhythm1.19381758
48MP0002882_abnormal_neuron_morphology1.18588415
49MP0008874_decreased_physiological_sensi1.16986238
50MP0005671_abnormal_response_to1.15089140
51MP0003631_nervous_system_phenotype1.11800585
52MP0003879_abnormal_hair_cell1.10399694
53MP0005646_abnormal_pituitary_gland1.08895473
54MP0000703_abnormal_thymus_morphology1.07536575
55MP0008872_abnormal_physiological_respon1.06648387
56MP0000569_abnormal_digit_pigmentation1.05296894
57MP0004742_abnormal_vestibular_system1.04160258
58MP0003183_abnormal_peptide_metabolism1.03315142
59MP0003045_fibrosis1.02810217
60MP0003283_abnormal_digestive_organ1.01975006
61MP0002152_abnormal_brain_morphology1.01341170
62MP0003123_paternal_imprinting1.00281312
63MP0005310_abnormal_salivary_gland1.00266978
64MP0005645_abnormal_hypothalamus_physiol0.98883248
65MP0001873_stomach_inflammation0.97918675
66MP0003300_gastrointestinal_ulcer0.97182066
67MP0000920_abnormal_myelination0.95488422
68MP0001984_abnormal_olfaction0.94206181
69MP0002638_abnormal_pupillary_reflex0.93242416
70MP0003303_peritoneal_inflammation0.93071322
71MP0000604_amyloidosis0.90878398
72MP0002069_abnormal_eating/drinking_beha0.90107516
73MP0002398_abnormal_bone_marrow0.89048642
74MP0004142_abnormal_muscle_tone0.88376036
75MP0003075_altered_response_to0.88139109
76MP0004130_abnormal_muscle_cell0.85462602
77MP0001905_abnormal_dopamine_level0.84667118
78MP0001188_hyperpigmentation0.84513277
79MP0001986_abnormal_taste_sensitivity0.84132116
80MP0001800_abnormal_humoral_immune0.84079874
81MP0003690_abnormal_glial_cell0.83127548
82MP0000685_abnormal_immune_system0.83046785
83MP0002420_abnormal_adaptive_immunity0.82699542
84MP0001819_abnormal_immune_cell0.80346021
85MP0003172_abnormal_lysosome_physiology0.77583966
86MP0003121_genomic_imprinting0.76909902
87MP0003938_abnormal_ear_development0.75839512
88MP0002006_tumorigenesis0.75779081
89MP0005535_abnormal_body_temperature0.75571272
90MP0002166_altered_tumor_susceptibility0.74212957
91MP0002229_neurodegeneration0.71964463
92MP0002752_abnormal_somatic_nervous0.70583878
93MP0001790_abnormal_immune_system0.70567655
94MP0005387_immune_system_phenotype0.70567655
95MP0002723_abnormal_immune_serum0.69776404
96MP0000716_abnormal_immune_system0.69536816
97MP0001529_abnormal_vocalization0.68563558
98MP0000026_abnormal_inner_ear0.68142375
99MP0003634_abnormal_glial_cell0.66854239
100MP0004484_altered_response_of0.65446967
101MP0005551_abnormal_eye_electrophysiolog0.65271242
102MP0001963_abnormal_hearing_physiology0.63487071
103MP0006276_abnormal_autonomic_nervous0.63124826
104MP0003861_abnormal_nervous_system0.62477516
105MP0005394_taste/olfaction_phenotype0.60464750
106MP0005499_abnormal_olfactory_system0.60464750
107MP0003632_abnormal_nervous_system0.60455534
108MP0005409_darkened_coat_color0.60023976
109MP0001765_abnormal_ion_homeostasis0.59986020
110MP0001943_abnormal_respiration0.59464747
111MP0002082_postnatal_lethality0.59448888
112MP0010770_preweaning_lethality0.59448888
113MP0010769_abnormal_survival0.59330371
114MP0001485_abnormal_pinna_reflex0.59119985
115MP0005000_abnormal_immune_tolerance0.57976281
116MP0002249_abnormal_larynx_morphology0.56090470
117MP0010768_mortality/aging0.55888279
118MP0005167_abnormal_blood-brain_barrier0.55204929
119MP0002722_abnormal_immune_system0.54086481
120MP0000631_abnormal_neuroendocrine_gland0.53525400
121MP0000566_synostosis0.53454251
122MP0001177_atelectasis0.53012791
123MP0005166_decreased_susceptibility_to0.52909414
124MP0002653_abnormal_ependyma_morphology0.49810778
125MP0003956_abnormal_body_size0.47760055
126MP0005174_abnormal_tail_pigmentation0.46783259
127MP0005388_respiratory_system_phenotype0.46562650
128MP0002133_abnormal_respiratory_system0.46562650
129MP0001664_abnormal_digestion0.45447274

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.27239374
2Myokymia (HP:0002411)5.78035880
3Focal seizures (HP:0007359)4.96540398
4Visual hallucinations (HP:0002367)4.36292589
5Neurofibrillary tangles (HP:0002185)4.22956371
6Action tremor (HP:0002345)3.90293988
7Progressive cerebellar ataxia (HP:0002073)3.86029579
8Atonic seizures (HP:0010819)3.82779135
9Febrile seizures (HP:0002373)3.78425709
10Epileptic encephalopathy (HP:0200134)3.77148914
11Absence seizures (HP:0002121)3.48009293
12T lymphocytopenia (HP:0005403)3.47401563
13Limb dystonia (HP:0002451)3.38115338
14Dysmetric saccades (HP:0000641)3.31638134
15Truncal ataxia (HP:0002078)3.27584982
16Broad-based gait (HP:0002136)3.26527629
17Abnormality of T cell number (HP:0011839)3.22423543
18Dysmetria (HP:0001310)3.19511916
19Dialeptic seizures (HP:0011146)3.18995708
20Impaired smooth pursuit (HP:0007772)3.17342804
21Gaze-evoked nystagmus (HP:0000640)3.17042220
22Impaired vibration sensation in the lower limbs (HP:0002166)3.13595353
23Annular pancreas (HP:0001734)3.13542818
24Diplopia (HP:0000651)3.13509404
25Abnormality of binocular vision (HP:0011514)3.13509404
26Hemiplegia (HP:0002301)3.13283389
27Urinary urgency (HP:0000012)3.06191368
28Genetic anticipation (HP:0003743)2.87248506
29Abnormality of the lower motor neuron (HP:0002366)2.85664949
30Supranuclear gaze palsy (HP:0000605)2.83395811
31Abnormality of ocular smooth pursuit (HP:0000617)2.82965937
32Abnormal social behavior (HP:0012433)2.82592700
33Impaired social interactions (HP:0000735)2.82592700
34Scanning speech (HP:0002168)2.81679109
35Dysdiadochokinesis (HP:0002075)2.78976419
36Depression (HP:0000716)2.73615976
37Poor eye contact (HP:0000817)2.73160867
38Stereotypic behavior (HP:0000733)2.71295254
39Urinary bladder sphincter dysfunction (HP:0002839)2.70401990
40Polyphagia (HP:0002591)2.69669069
41Papilledema (HP:0001085)2.69617943
42Tetraplegia (HP:0002445)2.68564745
43Chronic otitis media (HP:0000389)2.68128391
44Torticollis (HP:0000473)2.66579429
45Akinesia (HP:0002304)2.65982859
46Generalized tonic-clonic seizures (HP:0002069)2.65699236
47Peripheral hypomyelination (HP:0007182)2.64809671
48Pointed chin (HP:0000307)2.63040092
49Increased circulating renin level (HP:0000848)2.57725932
50Abnormal eating behavior (HP:0100738)2.57725761
51Neuronal loss in central nervous system (HP:0002529)2.56561888
52Ankle clonus (HP:0011448)2.54601386
53Hyperventilation (HP:0002883)2.54372604
54Spastic gait (HP:0002064)2.52219568
55Epileptiform EEG discharges (HP:0011182)2.51977424
56Lower limb muscle weakness (HP:0007340)2.51924715
57Sleep apnea (HP:0010535)2.47130071
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41809655
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.41809655
60Abnormality of the fingertips (HP:0001211)2.41650187
61Megalencephaly (HP:0001355)2.41318452
62Amblyopia (HP:0000646)2.36938474
63Clonus (HP:0002169)2.35741376
64Intention tremor (HP:0002080)2.34425623
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.31523308
66Nasal polyposis (HP:0100582)2.31324588
67Abnormality of oral frenula (HP:0000190)2.28044464
68Drooling (HP:0002307)2.27587336
69Excessive salivation (HP:0003781)2.27587336
70Panhypogammaglobulinemia (HP:0003139)2.23552473
71Postural instability (HP:0002172)2.23353459
72Anxiety (HP:0000739)2.19410766
73Stomatitis (HP:0010280)2.19064370
74Spinal canal stenosis (HP:0003416)2.18910889
75Lower limb asymmetry (HP:0100559)2.16392783
76Progressive inability to walk (HP:0002505)2.15965011
77Metabolic alkalosis (HP:0200114)2.15744009
78Deep palmar crease (HP:0006191)2.15173707
79EEG with generalized epileptiform discharges (HP:0011198)2.14493721
80Apathy (HP:0000741)2.13105050
81Spastic tetraparesis (HP:0001285)2.12033461
82Macroorchidism (HP:0000053)2.08048631
83Impaired vibratory sensation (HP:0002495)2.07106241
84Amyotrophic lateral sclerosis (HP:0007354)2.07034172
85Abnormality of saccadic eye movements (HP:0000570)2.04020261
86Recurrent bronchitis (HP:0002837)2.03664865
87Focal dystonia (HP:0004373)2.02683996
88Hemiparesis (HP:0001269)2.02448769
89Hypsarrhythmia (HP:0002521)2.01938594
90Rapidly progressive (HP:0003678)2.00456001
91Fetal akinesia sequence (HP:0001989)1.98874266
92Abnormality of T cells (HP:0002843)1.98683844
93Morphological abnormality of the pyramidal tract (HP:0002062)1.97256358
94Termporal pattern (HP:0011008)1.94409951
95Insidious onset (HP:0003587)1.94409951
96Mutism (HP:0002300)1.93144292
97Split foot (HP:0001839)1.92016323
98Diminished motivation (HP:0000745)1.91099443
99Cerebral inclusion bodies (HP:0100314)1.90455828
100Turricephaly (HP:0000262)1.89874675
101Abnormality of the corticospinal tract (HP:0002492)1.88803539
102Ankyloglossia (HP:0010296)1.88659085
103Craniofacial dystonia (HP:0012179)1.87952703
104Hyperacusis (HP:0010780)1.87420177
105Insomnia (HP:0100785)1.87158521
106Bronchomalacia (HP:0002780)1.86205793
107Thickened helices (HP:0000391)1.83715647
108Basal cell carcinoma (HP:0002671)1.83182064
109Rigidity (HP:0002063)1.83084171
110Gait ataxia (HP:0002066)1.82549296
111Chronic sinusitis (HP:0011109)1.82442633
112Bradykinesia (HP:0002067)1.81772708
113Aqueductal stenosis (HP:0002410)1.79959878
114Abnormality of the nasal mucosa (HP:0000433)1.78972801
115Cerebral hypomyelination (HP:0006808)1.78555353
116Obstructive sleep apnea (HP:0002870)1.76368473
117Status epilepticus (HP:0002133)1.75140937
118Obsessive-compulsive behavior (HP:0000722)1.74181308
119Recurrent cutaneous fungal infections (HP:0011370)1.73697560
120Chronic mucocutaneous candidiasis (HP:0002728)1.73697560
121Aplasia involving bones of the extremities (HP:0009825)1.73257592
122Aplasia involving bones of the upper limbs (HP:0009823)1.73257592
123Aplasia of the phalanges of the hand (HP:0009802)1.73257592
124Memory impairment (HP:0002354)1.73106269
125Deeply set eye (HP:0000490)1.73058101
126Papilloma (HP:0012740)1.72029074
127Verrucae (HP:0200043)1.72029074
128Ocular albinism (HP:0001107)1.71915840
129Narrow palate (HP:0000189)1.71805414
130Severe combined immunodeficiency (HP:0004430)1.71312139
131Autism (HP:0000717)1.70842870
132Bundle branch block (HP:0011710)1.70565802
133Mild short stature (HP:0003502)1.70432621
134Inappropriate behavior (HP:0000719)1.69985811
135Delusions (HP:0000746)1.69605413
136Ventricular fibrillation (HP:0001663)1.69462320
137Blue irides (HP:0000635)1.68698582
138Absent speech (HP:0001344)1.68546205
139Iris hypopigmentation (HP:0007730)1.67678797
140Hypoplasia of the corpus callosum (HP:0002079)1.67645782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.84249611
2EPHA43.51451683
3CASK3.42978672
4MAP3K93.28643937
5MAP3K132.66816357
6MAP4K12.46021660
7NTRK22.42499162
8SIK22.06170915
9TXK2.02245416
10TYRO31.99989980
11MAP3K41.99027434
12KSR21.98047450
13GRK61.96926908
14MINK11.86733388
15RIPK41.85827596
16PAK61.78374710
17FES1.70659112
18PRKCH1.66828338
19PRPF4B1.64152470
20PRKD31.59079198
21KSR11.58518574
22STK381.57815186
23DAPK21.54931306
24CAMKK11.53658244
25ITK1.46137549
26LATS21.45894751
27MARK11.34122626
28MAP3K71.32869992
29TAOK11.32734628
30TNIK1.31383030
31FGFR31.30143173
32CDK51.28266037
33EEF2K1.25821842
34TNK21.23870099
35MARK21.23754110
36SGK31.22129893
37PDK11.19569258
38DAPK11.18153163
39MAP2K71.15804170
40ALK1.10400262
41FGFR41.09698009
42SGK21.08497456
43STK111.05747444
44NTRK11.02918103
45JAK11.00733711
46PRKCQ1.00627878
47MAP3K121.00355390
48MAP2K40.99110286
49RET0.98390582
50PRKD20.94516606
51FGFR20.94439402
52PNCK0.92938999
53MAP3K20.92746417
54RAF10.92598773
55CAMK1G0.91546602
56PINK10.91436907
57SGK2230.90086201
58SGK4940.90086201
59CDK11A0.88552816
60JAK30.88512621
61CDK190.88347391
62CAMK10.87008065
63RIPK10.84996780
64DMPK0.84377128
65CDK140.83551335
66PHKG10.82430664
67PHKG20.82430664
68GRK50.79514370
69HCK0.79188635
70UHMK10.77931189
71OXSR10.77162749
72CAMKK20.76748915
73PRKCG0.76532032
74LMTK20.74832213
75ZAP700.73502763
76PKN20.72873416
77CAMK2B0.72751734
78SIK30.72170153
79PKN10.71413122
80PRKCZ0.70659380
81PDPK10.69614783
82IKBKE0.69584672
83SGK10.67932387
84NEK60.67581927
85SYK0.67318245
86MAP3K100.67241592
87BMPR20.66464226
88CAMK2G0.66003855
89LCK0.65695559
90DYRK1A0.65188631
91PTK2B0.63625656
92MARK30.63555109
93PAK30.62964011
94FYN0.62811371
95MOS0.62105511
96STK100.60377226
97CAMK40.59158339
98CAMK2A0.59135973
99WNK10.58629899
100CAMK2D0.57726774
101MAP3K110.57555153
102PDGFRB0.55351102
103PLK20.55107644
104JAK20.52789127
105STK390.52780353
106HIPK20.51471358
107CDK180.50931852
108CDK150.49990984
109MAPK120.49052987
110MAPK130.48713517
111FGR0.48666407
112CAMK1D0.48443988
113TRIB30.47742434
114IRAK20.47148586
115ARAF0.46788348
116ROCK20.46094011
117MAPK100.45729618
118NLK0.45388036
119RPS6KA30.45206351
120ERBB20.44963529
121MAPK40.38486244
122DYRK1B0.36506762
123DYRK20.36420825
124BRAF0.34600676
125RPS6KB10.31957499
126MAP3K10.30840311
127MAPK80.30633005
128PRKCA0.30010487
129RPS6KA20.29769893
130EPHB20.29625031
131PRKG10.27988253

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.83322931
2Long-term potentiation_Homo sapiens_hsa047202.65055326
3Olfactory transduction_Homo sapiens_hsa047402.29432890
4Circadian entrainment_Homo sapiens_hsa047132.24966505
5Glutamatergic synapse_Homo sapiens_hsa047242.20886433
6Morphine addiction_Homo sapiens_hsa050322.12051276
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11223894
8Salivary secretion_Homo sapiens_hsa049702.06136899
9Amphetamine addiction_Homo sapiens_hsa050311.99865800
10GABAergic synapse_Homo sapiens_hsa047271.94972281
11Synaptic vesicle cycle_Homo sapiens_hsa047211.93975859
12Gastric acid secretion_Homo sapiens_hsa049711.89016999
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82905888
14T cell receptor signaling pathway_Homo sapiens_hsa046601.79288422
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75332314
16Dopaminergic synapse_Homo sapiens_hsa047281.73680204
17Cholinergic synapse_Homo sapiens_hsa047251.67370649
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.63759587
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63647021
20Renin secretion_Homo sapiens_hsa049241.58646655
21Insulin secretion_Homo sapiens_hsa049111.57425596
22Oxytocin signaling pathway_Homo sapiens_hsa049211.54424041
23Primary immunodeficiency_Homo sapiens_hsa053401.49184004
24Long-term depression_Homo sapiens_hsa047301.49001700
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43352078
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39214873
27Calcium signaling pathway_Homo sapiens_hsa040201.38518520
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37111183
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37004465
30GnRH signaling pathway_Homo sapiens_hsa049121.34990278
31Taste transduction_Homo sapiens_hsa047421.27598266
32Type II diabetes mellitus_Homo sapiens_hsa049301.22026382
33cAMP signaling pathway_Homo sapiens_hsa040241.20693760
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20188204
35Glioma_Homo sapiens_hsa052141.18516235
36Cocaine addiction_Homo sapiens_hsa050301.16534952
37Dorso-ventral axis formation_Homo sapiens_hsa043201.15431043
38Estrogen signaling pathway_Homo sapiens_hsa049151.13502946
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07834475
40ErbB signaling pathway_Homo sapiens_hsa040121.07566540
41VEGF signaling pathway_Homo sapiens_hsa043701.07327927
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.06339272
43Serotonergic synapse_Homo sapiens_hsa047261.04298040
44Choline metabolism in cancer_Homo sapiens_hsa052311.03569310
45Gap junction_Homo sapiens_hsa045401.03324873
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.97097467
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95949389
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94935128
49Melanogenesis_Homo sapiens_hsa049160.93962223
50Chemokine signaling pathway_Homo sapiens_hsa040620.92810306
51MAPK signaling pathway_Homo sapiens_hsa040100.92733875
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91239994
53Non-small cell lung cancer_Homo sapiens_hsa052230.91121599
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90203248
55Nitrogen metabolism_Homo sapiens_hsa009100.90201330
56mTOR signaling pathway_Homo sapiens_hsa041500.90055766
57B cell receptor signaling pathway_Homo sapiens_hsa046620.89028150
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88599331
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.87846391
60Axon guidance_Homo sapiens_hsa043600.86273504
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85681345
62Inositol phosphate metabolism_Homo sapiens_hsa005620.84091459
63Pancreatic secretion_Homo sapiens_hsa049720.82326465
64Rap1 signaling pathway_Homo sapiens_hsa040150.79997314
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79537834
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79019740
67Colorectal cancer_Homo sapiens_hsa052100.78840828
68Endometrial cancer_Homo sapiens_hsa052130.77441415
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76963681
70Osteoclast differentiation_Homo sapiens_hsa043800.74266978
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74258247
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73599654
73Thyroid hormone synthesis_Homo sapiens_hsa049180.73492676
74Prion diseases_Homo sapiens_hsa050200.73068957
75Histidine metabolism_Homo sapiens_hsa003400.70615548
76Renal cell carcinoma_Homo sapiens_hsa052110.69749046
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.68777972
78Platelet activation_Homo sapiens_hsa046110.67625171
79Oocyte meiosis_Homo sapiens_hsa041140.66982488
80Endocytosis_Homo sapiens_hsa041440.65853976
81Ras signaling pathway_Homo sapiens_hsa040140.65183889
82Prolactin signaling pathway_Homo sapiens_hsa049170.63742687
83Vitamin B6 metabolism_Homo sapiens_hsa007500.62487273
84Protein digestion and absorption_Homo sapiens_hsa049740.62004834
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61810304
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61137571
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60468413
88Cardiac muscle contraction_Homo sapiens_hsa042600.59471363
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58128766
90Arginine biosynthesis_Homo sapiens_hsa002200.57449389
91Alcoholism_Homo sapiens_hsa050340.57070258
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55071073
93Pancreatic cancer_Homo sapiens_hsa052120.54684024
94Type I diabetes mellitus_Homo sapiens_hsa049400.53606317
95Glucagon signaling pathway_Homo sapiens_hsa049220.53235875
96Acute myeloid leukemia_Homo sapiens_hsa052210.52986541
97Chronic myeloid leukemia_Homo sapiens_hsa052200.52514419
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50557142
99Dilated cardiomyopathy_Homo sapiens_hsa054140.50510266
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49714258
101Wnt signaling pathway_Homo sapiens_hsa043100.49244406
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48964078
103Mineral absorption_Homo sapiens_hsa049780.48700752
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47137463
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46643641
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45257458
107African trypanosomiasis_Homo sapiens_hsa051430.42784846
108Renin-angiotensin system_Homo sapiens_hsa046140.42234743
109Insulin signaling pathway_Homo sapiens_hsa049100.41403608
110FoxO signaling pathway_Homo sapiens_hsa040680.41116797
111Bile secretion_Homo sapiens_hsa049760.40694985
112Collecting duct acid secretion_Homo sapiens_hsa049660.40343153
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37900949
114Notch signaling pathway_Homo sapiens_hsa043300.29235445
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.27917942
116AMPK signaling pathway_Homo sapiens_hsa041520.27303371
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.26376467
118Arginine and proline metabolism_Homo sapiens_hsa003300.25421731
119HIF-1 signaling pathway_Homo sapiens_hsa040660.25127892

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