ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sarcomere organization (GO:0045214)	8.69109840
2	muscle filament sliding (GO:0030049)	8.49035684
3	actin-myosin filament sliding (GO:0033275)	8.49035684
4	cardiac myofibril assembly (GO:0055003)	7.94469887
5	myofibril assembly (GO:0030239)	7.91829094
6	regulation of skeletal muscle contraction (GO:0014819)	7.72965986
7	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	7.51661080
8	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	7.18902986
9	actin-mediated cell contraction (GO:0070252)	7.09119384
10	regulation of relaxation of muscle (GO:1901077)	6.84795849
11	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	6.82769589
12	tricarboxylic acid cycle (GO:0006099)	6.59481529
13	sarcoplasmic reticulum calcium ion transport (GO:0070296)	6.46626941
14	cardiac muscle contraction (GO:0060048)	6.40552200
15	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	6.18398531
16	regulation of cell communication by electrical coupling (GO:0010649)	6.16940219
17	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	5.98186861
18	regulation of actin filament-based movement (GO:1903115)	5.94512404
19	negative regulation of potassium ion transmembrane transport (GO:1901380)	5.93227097
20	striated muscle contraction (GO:0006941)	5.90147392
21	actomyosin structure organization (GO:0031032)	5.68081196
22	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	5.63453376
23	cardiac muscle hypertrophy (GO:0003300)	5.56129447
24	cardiac muscle cell development (GO:0055013)	5.53429376
25	plasma membrane repair (GO:0001778)	5.52781891
26	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	5.52077052
27	regulation of acyl-CoA biosynthetic process (GO:0050812)	5.50491563
28	regulation of sarcomere organization (GO:0060297)	5.47115695
29	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	5.42315421
30	skeletal muscle contraction (GO:0003009)	5.39533290
31	striated muscle hypertrophy (GO:0014897)	5.34284985
32	heart process (GO:0003015)	5.29870523
33	heart contraction (GO:0060047)	5.29870523
34	carnitine shuttle (GO:0006853)	5.29058039
35	cardiac cell development (GO:0055006)	5.17096779
36	skeletal muscle fiber development (GO:0048741)	5.16146989
37	actin filament-based movement (GO:0030048)	5.15563061
38	cardiac muscle tissue morphogenesis (GO:0055008)	5.12154733
39	regulation of striated muscle contraction (GO:0006942)	4.99648017
40	myotube cell development (GO:0014904)	4.98747164
41	adult heart development (GO:0007512)	4.98402902
42	regulation of coenzyme metabolic process (GO:0051196)	4.91915756
43	regulation of cofactor metabolic process (GO:0051193)	4.91915756
44	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	4.87009027
45	muscle hypertrophy (GO:0014896)	4.82823806
46	ventricular cardiac muscle cell action potential (GO:0086005)	4.80871162
47	muscle tissue morphogenesis (GO:0060415)	4.64903545
48	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.56283615
49	NADH metabolic process (GO:0006734)	4.54786673
50	skeletal muscle adaptation (GO:0043501)	4.52157428
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.51785234
52	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	4.50389801
53	fatty acid transmembrane transport (GO:1902001)	4.49100218
54	muscle fiber development (GO:0048747)	4.39389136
55	regulation of membrane repolarization (GO:0060306)	4.37563018
56	oxidative phosphorylation (GO:0006119)	4.30257623
57	response to inactivity (GO:0014854)	4.18226127
58	glucan biosynthetic process (GO:0009250)	4.14305617
59	glycogen biosynthetic process (GO:0005978)	4.14305617
60	muscle contraction (GO:0006936)	4.09770058
61	respiratory electron transport chain (GO:0022904)	4.07787897
62	regulation of sulfur metabolic process (GO:0042762)	4.00876252
63	striated muscle adaptation (GO:0014888)	4.00689481
64	cardiac muscle cell action potential (GO:0086001)	3.96183350
65	electron transport chain (GO:0022900)	3.96087000
66	skeletal muscle tissue development (GO:0007519)	3.95716656
67	cardiac muscle adaptation (GO:0014887)	3.95485036
68	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.95485036
69	muscle hypertrophy in response to stress (GO:0003299)	3.95485036
70	heart trabecula formation (GO:0060347)	3.94665902
71	cardiac muscle cell action potential involved in contraction (GO:0086002)	3.92533646
72	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.91933688
73	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.91616349
74	creatine metabolic process (GO:0006600)	3.89975794
75	regulation of cardiac muscle contraction (GO:0055117)	3.89176258
76	cellular polysaccharide catabolic process (GO:0044247)	3.86479638
77	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	3.85188442
78	muscle system process (GO:0003012)	3.84610102
79	carnitine transmembrane transport (GO:1902603)	3.81539931
80	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.80397845
81	glycogen catabolic process (GO:0005980)	3.77589260
82	regulation of cardiac muscle cell contraction (GO:0086004)	3.76002917
83	regulation of the force of heart contraction (GO:0002026)	3.71664808
84	quinone biosynthetic process (GO:1901663)	3.68513970
85	ubiquinone biosynthetic process (GO:0006744)	3.68513970
86	regulation of heart rate (GO:0002027)	3.66015135
87	skeletal muscle tissue regeneration (GO:0043403)	3.65316907
88	striated muscle cell development (GO:0055002)	3.63252413
89	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.62853095
90	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.61604246
91	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.61604246
92	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.60867997
93	ATP synthesis coupled proton transport (GO:0015986)	3.60867997
94	succinate metabolic process (GO:0006105)	3.58456203
95	cell communication involved in cardiac conduction (GO:0086065)	3.57203668
96	regulation of sequestering of triglyceride (GO:0010889)	3.56597562
97	positive regulation of cation channel activity (GO:2001259)	3.56391085
98	response to muscle activity (GO:0014850)	3.53989402
99	oxaloacetate metabolic process (GO:0006107)	3.53264436
100	striated muscle atrophy (GO:0014891)	3.52738261
101	2-oxoglutarate metabolic process (GO:0006103)	3.52079212
102	positive regulation of heart rate (GO:0010460)	3.50995626
103	glucan catabolic process (GO:0009251)	3.49693810
104	neuronal action potential propagation (GO:0019227)	3.49036532
105	ubiquinone metabolic process (GO:0006743)	3.48770406
106	cytidine metabolic process (GO:0046087)	3.48437258
107	cytidine catabolic process (GO:0006216)	3.48437258
108	cytidine deamination (GO:0009972)	3.48437258
109	polysaccharide catabolic process (GO:0000272)	3.46595787
110	regulation of calcium ion transmembrane transport (GO:1903169)	3.46386144
111	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.46386144
112	negative regulation of protein localization to cell surface (GO:2000009)	3.46090726
113	cardiac conduction (GO:0061337)	3.43647127
114	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.43298347
115	muscle adaptation (GO:0043500)	3.42793519
116	behavioral response to nicotine (GO:0035095)	3.36444393
117	neuromuscular synaptic transmission (GO:0007274)	3.33942447
118	muscle cell cellular homeostasis (GO:0046716)	3.32005978
119	response to caffeine (GO:0031000)	3.29447092
120	muscle structure development (GO:0061061)	3.26145494
121	muscle organ development (GO:0007517)	3.23317321
122	response to activity (GO:0014823)	3.20058731
123	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.19906354
124	glycogen metabolic process (GO:0005977)	3.14278399
125	relaxation of muscle (GO:0090075)	3.07989089
126	glucan metabolic process (GO:0044042)	3.06519861
127	cellular glucan metabolic process (GO:0006073)	3.06519861
128	otic vesicle formation (GO:0030916)	3.02985615
129	aspartate family amino acid catabolic process (GO:0009068)	3.02697503
130	muscle cell fate commitment (GO:0042693)	2.96376446
131	muscle organ morphogenesis (GO:0048644)	2.95912674
132	regulation of muscle system process (GO:0090257)	2.91945538
133	regulation of ATPase activity (GO:0043462)	2.87600404
134	regulation of ATP catabolic process (GO:1903289)	2.87600404
135	membrane depolarization during action potential (GO:0086010)	2.87522558

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.99194806
2	EP300_21415370_ChIP-Seq_HL-1_Mouse	4.73594138
3	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	4.39131141
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.31643246
5	TBX20_22080862_ChIP-Seq_HEART_Mouse	3.36494519
6	TBX20_22328084_ChIP-Seq_HEART_Mouse	3.36494519
7	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.32949755
8	EZH2_22144423_ChIP-Seq_EOC_Human	3.18075302
9	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.06150762
10	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	3.03002358
11	GATA4_21415370_ChIP-Seq_HL-1_Mouse	2.85793525
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.73301395
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59039542
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52548170
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.46134931
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.45065716
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41495432
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.31537521
19	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.30582108
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30158218
21	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.93463657
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80197147
23	GATA1_22025678_ChIP-Seq_K562_Human	1.77006236
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.73620250
25	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.71744795
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70430970
27	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.57727816
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.52169353
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.50273319
30	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.50070673
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49119169
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.47444084
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40223785
34	P300_19829295_ChIP-Seq_ESCs_Human	1.39148455
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38146363
36	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38146363
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34021595
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.33778506
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32783279
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30636325
41	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26318304
42	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.24693257
43	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.23403965
44	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.21623900
45	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21151991
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.19602148
47	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.19588200
48	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.19021478
49	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.16963560
50	AR_25329375_ChIP-Seq_VCAP_Human	1.16955111
51	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.16610054
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15291475
53	STAT3_23295773_ChIP-Seq_U87_Human	1.13979268
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.13949756
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.13337537
56	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.12805966
57	DROSHA_22980978_ChIP-Seq_HELA_Human	1.12527658
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12315879
59	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12206081
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12034121
61	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.10366665
62	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.09819972
63	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09417256
64	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09399145
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08321384
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07921665
67	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.07692918
68	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05316574
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05187456
70	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.05056028
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03607087
72	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.03396944
73	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.00760433
74	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99916321
75	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99510554
76	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99478604
77	BCAT_22108803_ChIP-Seq_LS180_Human	0.99459685
78	NCOR_22424771_ChIP-Seq_293T_Human	0.99287309
79	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.99043379
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98003320
81	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97948142
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97897168
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.97197787
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97143975
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.96799051
86	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.96186489
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95725753
88	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95714651
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95527478
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94249999
91	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.94026207
92	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94022714
93	CDX2_22108803_ChIP-Seq_LS180_Human	0.92842976
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92795191
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.92543927
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.92496902
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92413039
98	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.92292145
99	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.92022810
100	HTT_18923047_ChIP-ChIP_STHdh_Human	0.91736887
101	ZNF274_21170338_ChIP-Seq_K562_Hela	0.91460244
102	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.91094885
103	* MYC_19829295_ChIP-Seq_ESCs_Human	0.90313667
104	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89603639
105	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89074500
106	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.88261443
107	TBL1_22424771_ChIP-Seq_293T_Human	0.88068171
108	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.87976080
109	TCF4_23295773_ChIP-Seq_U87_Human	0.86562568
110	VDR_22108803_ChIP-Seq_LS180_Human	0.86276586
111	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.86009525
112	CJUN_26792858_Chip-Seq_BT549_Human	0.85758653
113	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.84963149
114	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.84200078
115	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.83416127
116	ETV1_20927104_ChIP-Seq_GIST48_Human	0.82895855
117	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.82633407
118	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.82633407
119	TAF15_26573619_Chip-Seq_HEK293_Human	0.81884891
120	FUS_26573619_Chip-Seq_HEK293_Human	0.81860898
121	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.81740827
122	CTCF_27219007_Chip-Seq_Bcells_Human	0.81672746
123	PHF8_20622853_ChIP-Seq_HELA_Human	0.81369681
124	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.80503634
125	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.80281164
126	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.79821920
127	NFYA_21822215_ChIP-Seq_K562_Human	0.79524619
128	CBP_21632823_ChIP-Seq_H3396_Human	0.79227627
129	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.78293973
130	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.78153418
131	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.78010071
132	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77578395
133	CBP_20019798_ChIP-Seq_JUKART_Human	0.77578395
134	NFYB_21822215_ChIP-Seq_K562_Human	0.77305416
135	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.77100187

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	6.44024095
2	MP0002837_dystrophic_cardiac_calcinosis	6.31749696
3	MP0000751_myopathy	5.24918651
4	MP0004084_abnormal_cardiac_muscle	4.96771737
5	MP0000749_muscle_degeneration	4.91474586
6	MP0004215_abnormal_myocardial_fiber	4.51103899
7	MP0004036_abnormal_muscle_relaxation	4.45162806
8	MP0004145_abnormal_muscle_electrophysio	3.91566138
9	MP0005330_cardiomyopathy	3.55749550
10	MP0004087_abnormal_muscle_fiber	3.13109455
11	MP0005620_abnormal_muscle_contractility	3.08561234
12	MP0002106_abnormal_muscle_physiology	3.08294140
13	MP0004130_abnormal_muscle_cell	3.07901612
14	MP0002972_abnormal_cardiac_muscle	2.95652005
15	MP0000750_abnormal_muscle_regeneration	2.81732249
16	MP0002269_muscular_atrophy	2.61852575
17	MP0003137_abnormal_impulse_conducting	2.60274356
18	MP0008775_abnormal_heart_ventricle	2.58775905
19	MP0004484_altered_response_of	2.56563352
20	MP0005369_muscle_phenotype	2.55233665
21	MP0000759_abnormal_skeletal_muscle	2.42419306
22	MP0000747_muscle_weakness	2.38263584
23	MP0001544_abnormal_cardiovascular_syste	2.28353435
24	MP0005385_cardiovascular_system_phenoty	2.28353435
25	MP0010630_abnormal_cardiac_muscle	2.23787282
26	MP0006036_abnormal_mitochondrial_physio	2.11283733
27	MP0006138_congestive_heart_failure	2.00679458
28	MP0004233_abnormal_muscle_weight	1.96807118
29	MP0004085_abnormal_heartbeat	1.92267482
30	MP0003828_pulmonary_edema	1.82144268
31	MP0003221_abnormal_cardiomyocyte_apopto	1.79977233
32	MP0002127_abnormal_cardiovascular_syste	1.78519812
33	MP0004270_analgesia	1.75508796
34	MP0004510_myositis	1.70358057
35	MP0002332_abnormal_exercise_endurance	1.69840922
36	MP0003950_abnormal_plasma_membrane	1.36206611
37	MP0005670_abnormal_white_adipose	1.33096474
38	MP0005666_abnormal_adipose_tissue	1.22204570
39	MP0006035_abnormal_mitochondrial_morpho	1.19391498
40	MP0002108_abnormal_muscle_morphology	1.19041909
41	MP0004147_increased_porphyrin_level	1.13196071
42	MP0001661_extended_life_span	1.00882060
43	MP0000343_altered_response_to	1.00822860
44	MP0003567_abnormal_fetal_cardiomyocyte	0.98639151
45	MP0000266_abnormal_heart_morphology	0.97521968
46	MP0003045_fibrosis	0.93892233
47	MP0003806_abnormal_nucleotide_metabolis	0.92858761
48	MP0005266_abnormal_metabolism	0.90841990
49	MP0006276_abnormal_autonomic_nervous	0.89727746
50	MP0005165_increased_susceptibility_to	0.85442804
51	MP0004043_abnormal_pH_regulation	0.85291296
52	MP0001984_abnormal_olfaction	0.84043628
53	MP0000230_abnormal_systemic_arterial	0.82345894
54	MP0002234_abnormal_pharynx_morphology	0.81520317
55	MP0004185_abnormal_adipocyte_glucose	0.80489019
56	MP0005375_adipose_tissue_phenotype	0.75153908
57	MP0008872_abnormal_physiological_respon	0.74855003
58	MP0005167_abnormal_blood-brain_barrier	0.74533113
59	MP0002876_abnormal_thyroid_physiology	0.73495682
60	MP0002734_abnormal_mechanical_nocicepti	0.69431678
61	MP0003279_aneurysm	0.69403594
62	MP0010368_abnormal_lymphatic_system	0.69277877
63	MP0005645_abnormal_hypothalamus_physiol	0.68992467
64	MP0009745_abnormal_behavioral_response	0.66970350
65	MP0003136_yellow_coat_color	0.66392248
66	MP0002822_catalepsy	0.64895359
67	MP0002272_abnormal_nervous_system	0.64167059
68	MP0002971_abnormal_brown_adipose	0.63666243
69	MP0005551_abnormal_eye_electrophysiolog	0.63549362
70	MP0005423_abnormal_somatic_nervous	0.63484551
71	MP0000733_abnormal_muscle_development	0.63319271
72	MP0008877_abnormal_DNA_methylation	0.60806790
73	MP0001485_abnormal_pinna_reflex	0.60199335
74	MP0002078_abnormal_glucose_homeostasis	0.60082737
75	MP0003879_abnormal_hair_cell	0.58888417
76	MP0002128_abnormal_blood_circulation	0.57760199
77	MP0009046_muscle_twitch	0.56539146
78	MP0001486_abnormal_startle_reflex	0.55522967
79	MP0002067_abnormal_sensory_capabilities	0.54110389
80	MP0005332_abnormal_amino_acid	0.52187477
81	MP0000013_abnormal_adipose_tissue	0.51971826
82	MP0005253_abnormal_eye_physiology	0.50032296
83	MP0001501_abnormal_sleep_pattern	0.49772160
84	MP0004885_abnormal_endolymph	0.49130737
85	MP0009780_abnormal_chondrocyte_physiolo	0.48661806
86	MP0003195_calcinosis	0.47570909
87	MP0001986_abnormal_taste_sensitivity	0.45395912
88	MP0002064_seizures	0.44934475
89	MP0005451_abnormal_body_composition	0.44284319
90	MP0000372_irregular_coat_pigmentation	0.43999915
91	MP0005334_abnormal_fat_pad	0.43422907
92	MP0009697_abnormal_copulation	0.43309049
93	MP0005083_abnormal_biliary_tract	0.42641774
94	MP0004134_abnormal_chest_morphology	0.42548778
95	MP0003011_delayed_dark_adaptation	0.41382709
96	MP0001440_abnormal_grooming_behavior	0.41184113
97	MP0001529_abnormal_vocalization	0.40616061
98	MP0002066_abnormal_motor_capabilities/c	0.40022134
99	MP0000767_abnormal_smooth_muscle	0.39951597
100	MP0006072_abnormal_retinal_apoptosis	0.39912881
101	MP0002733_abnormal_thermal_nociception	0.38704012
102	MP0005646_abnormal_pituitary_gland	0.38523578
103	MP0005319_abnormal_enzyme/_coenzyme	0.37660227
104	MP0001968_abnormal_touch/_nociception	0.37640172
105	MP0000003_abnormal_adipose_tissue	0.36201621
106	MP0002638_abnormal_pupillary_reflex	0.35862290
107	MP0005535_abnormal_body_temperature	0.35728291
108	MP0001879_abnormal_lymphatic_vessel	0.35579366
109	MP0004924_abnormal_behavior	0.34320687
110	MP0005386_behavior/neurological_phenoty	0.34320687
111	MP0005171_absent_coat_pigmentation	0.31987045
112	MP0003656_abnormal_erythrocyte_physiolo	0.30618440
113	MP0008569_lethality_at_weaning	0.29640484
114	MP0003948_abnormal_gas_homeostasis	0.29166172
115	MP0003566_abnormal_cell_adhesion	0.26916828
116	MP0005452_abnormal_adipose_tissue	0.26016910
117	MP0009115_abnormal_fat_cell	0.25826782
118	MP0005595_abnormal_vascular_smooth	0.25787824
119	MP0004142_abnormal_muscle_tone	0.23386490
120	MP0005376_homeostasis/metabolism_phenot	0.23156402
121	MP0002909_abnormal_adrenal_gland	0.22901527
122	MP0001853_heart_inflammation	0.22774179
123	MP0002925_abnormal_cardiovascular_devel	0.21422298
124	MP0005584_abnormal_enzyme/coenzyme_acti	0.19938170
125	MP0008961_abnormal_basal_metabolism	0.19088376
126	MP0005085_abnormal_gallbladder_physiolo	0.17997931
127	MP0005623_abnormal_meninges_morphology	0.17407465
128	MP0003984_embryonic_growth_retardation	0.16229244
129	MP0002118_abnormal_lipid_homeostasis	0.14634166
130	MP0000678_abnormal_parathyroid_gland	0.14309465
131	MP0002088_abnormal_embryonic_growth/wei	0.14249731
132	MP0009384_cardiac_valve_regurgitation	0.13781337
133	MP0003953_abnormal_hormone_level	0.13746542
134	MP0005187_abnormal_penis_morphology	0.12930902
135	MP0001614_abnormal_blood_vessel	0.12747009

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Exercise-induced myalgia (HP:0003738)	7.25528190
2	Calf muscle hypertrophy (HP:0008981)	6.98165481
3	Sudden death (HP:0001699)	6.97130136
4	Exercise-induced muscle cramps (HP:0003710)	6.97076415
5	Muscle hypertrophy of the lower extremities (HP:0008968)	6.84654341
6	Ventricular tachycardia (HP:0004756)	5.80802146
7	Muscle fiber splitting (HP:0003555)	5.46959335
8	Myoglobinuria (HP:0002913)	5.27287925
9	Abnormality of the calf musculature (HP:0001430)	5.24621112
10	Atrial fibrillation (HP:0005110)	5.16252382
11	Subaortic stenosis (HP:0001682)	5.09615462
12	Abnormality of the left ventricular outflow tract (HP:0011103)	5.09615462
13	Hyporeflexia of lower limbs (HP:0002600)	4.81363152
14	Primary atrial arrhythmia (HP:0001692)	4.78708105
15	Muscle fiber inclusion bodies (HP:0100299)	4.67594191
16	Supraventricular tachycardia (HP:0004755)	4.61870785
17	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	4.61146222
18	Lipoatrophy (HP:0100578)	4.57536011
19	EMG: myopathic abnormalities (HP:0003458)	4.52958931
20	Supraventricular arrhythmia (HP:0005115)	4.49389978
21	Rhabdomyolysis (HP:0003201)	4.25285290
22	Nemaline bodies (HP:0003798)	3.99352696
23	Syncope (HP:0001279)	3.96997835
24	Increased connective tissue (HP:0009025)	3.96361981
25	Right ventricular cardiomyopathy (HP:0011663)	3.96266561
26	Dilated cardiomyopathy (HP:0001644)	3.91134701
27	Palpitations (HP:0001962)	3.82898258
28	Myotonia (HP:0002486)	3.80027369
29	Difficulty running (HP:0009046)	3.79550648
30	Bundle branch block (HP:0011710)	3.75648682
31	Asymmetric septal hypertrophy (HP:0001670)	3.68784011
32	Absent phalangeal crease (HP:0006109)	3.62862527
33	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.60625009
34	Type 1 muscle fiber predominance (HP:0003803)	3.55563672
35	Prolonged QT interval (HP:0001657)	3.55491093
36	Calcaneovalgus deformity (HP:0001848)	3.47866084
37	Abnormal mitochondria in muscle tissue (HP:0008316)	3.40674157
38	Acute necrotizing encephalopathy (HP:0006965)	3.39936098
39	Ventricular arrhythmia (HP:0004308)	3.33637789
40	Heart block (HP:0012722)	3.30128339
41	Frequent falls (HP:0002359)	3.25036907
42	Hepatic necrosis (HP:0002605)	3.24832848
43	Muscle stiffness (HP:0003552)	3.21711054
44	Distal lower limb muscle weakness (HP:0009053)	3.15397309
45	Deformed tarsal bones (HP:0008119)	3.12548830
46	Abnormal atrioventricular conduction (HP:0005150)	3.10169260
47	Abnormal finger flexion creases (HP:0006143)	3.04095681
48	Hepatocellular necrosis (HP:0001404)	3.03283292
49	Areflexia of lower limbs (HP:0002522)	3.02458649
50	Distal arthrogryposis (HP:0005684)	2.99616280
51	Atrioventricular block (HP:0001678)	2.94430184
52	Left ventricular hypertrophy (HP:0001712)	2.88896313
53	Progressive macrocephaly (HP:0004481)	2.85640603
54	Malignant hyperthermia (HP:0002047)	2.84199888
55	Acute encephalopathy (HP:0006846)	2.84159853
56	Neck muscle weakness (HP:0000467)	2.84107906
57	Mitochondrial inheritance (HP:0001427)	2.81869044
58	Difficulty climbing stairs (HP:0003551)	2.77649622
59	Increased CSF lactate (HP:0002490)	2.71161471
60	Rimmed vacuoles (HP:0003805)	2.67914470
61	Abnormal EKG (HP:0003115)	2.67835887
62	Round ear (HP:0100830)	2.65574559
63	Ventricular fibrillation (HP:0001663)	2.61387408
64	Myopathic facies (HP:0002058)	2.57837883
65	Exercise intolerance (HP:0003546)	2.57579294
66	Fetal akinesia sequence (HP:0001989)	2.54307468
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54186613
68	Abnormality of alanine metabolism (HP:0010916)	2.54186613
69	Hyperalaninemia (HP:0003348)	2.54186613
70	Abnormality of skeletal muscle fiber size (HP:0012084)	2.50710079
71	Cerebral edema (HP:0002181)	2.46793658
72	Weak cry (HP:0001612)	2.44574774
73	Increased variability in muscle fiber diameter (HP:0003557)	2.43736298
74	Lactic acidosis (HP:0003128)	2.36962196
75	Muscular dystrophy (HP:0003560)	2.29955773
76	Ketoacidosis (HP:0001993)	2.26979638
77	Palmoplantar keratoderma (HP:0000982)	2.25122469
78	Bulbar palsy (HP:0001283)	2.16495709
79	Ulnar deviation of the wrist (HP:0003049)	2.16476799
80	Respiratory failure (HP:0002878)	2.15651233
81	Increased muscle lipid content (HP:0009058)	2.15542086
82	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.15039285
83	Dicarboxylic aciduria (HP:0003215)	2.15039285
84	Limb-girdle muscle atrophy (HP:0003797)	2.12606490
85	Abnormality of fatty-acid metabolism (HP:0004359)	2.11761337
86	Generalized muscle weakness (HP:0003324)	2.09909481
87	Mildly elevated creatine phosphokinase (HP:0008180)	2.09049894
88	Hypoglycemic coma (HP:0001325)	2.05082734
89	Type 2 muscle fiber atrophy (HP:0003554)	2.02836252
90	Hip contracture (HP:0003273)	2.01638301
91	EMG: neuropathic changes (HP:0003445)	2.01067679
92	Progressive muscle weakness (HP:0003323)	1.99192201
93	Slender build (HP:0001533)	1.97657182
94	Pheochromocytoma (HP:0002666)	1.96851958
95	Increased intramyocellular lipid droplets (HP:0012240)	1.96258554
96	Ragged-red muscle fibers (HP:0003200)	1.93788166
97	Toxemia of pregnancy (HP:0100603)	1.93178258
98	Gowers sign (HP:0003391)	1.92431934
99	Insulin-resistant diabetes mellitus (HP:0000831)	1.92359529
100	Conjunctival hamartoma (HP:0100780)	1.91492312
101	Scapular winging (HP:0003691)	1.90747058
102	Facial diplegia (HP:0001349)	1.90385528
103	Hypoplastic ischia (HP:0003175)	1.89035380
104	Distal lower limb amyotrophy (HP:0008944)	1.88971772
105	Testicular atrophy (HP:0000029)	1.87617426
106	Proximal amyotrophy (HP:0007126)	1.85564460
107	Abnormality of glycolysis (HP:0004366)	1.85543238
108	Increased serum pyruvate (HP:0003542)	1.85543238
109	Neoplasm of the adrenal gland (HP:0100631)	1.84018628
110	Waddling gait (HP:0002515)	1.83600700
111	Esophageal neoplasm (HP:0100751)	1.83427455
112	Neoplasm of head and neck (HP:0012288)	1.83427455
113	Increased serum lactate (HP:0002151)	1.80931371
114	Fatigable weakness (HP:0003473)	1.78049156
115	Abnormality of the neuromuscular junction (HP:0003398)	1.78049156
116	Neuroendocrine neoplasm (HP:0100634)	1.77549487
117	Hyperkalemia (HP:0002153)	1.77504254
118	Nonprogressive disorder (HP:0003680)	1.77052584
119	Congestive heart failure (HP:0001635)	1.75942949
120	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.75831232
121	Abnormality of the shoulder girdle musculature (HP:0001435)	1.74206915
122	Muscle fiber atrophy (HP:0100295)	1.69950707
123	Abnormality of the foot musculature (HP:0001436)	1.67750570
124	Paralysis (HP:0003470)	1.64899223
125	Abnormality of the calcaneus (HP:0008364)	1.63515314
126	Long clavicles (HP:0000890)	1.54528492
127	Large for gestational age (HP:0001520)	1.53400634
128	Hyperglycinuria (HP:0003108)	1.51150592
129	Oligomenorrhea (HP:0000876)	1.47482852
130	Abnormality of potassium homeostasis (HP:0011042)	1.47250320
131	Steppage gait (HP:0003376)	1.45951827

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	6.16952184
2	TTN	5.41489873
3	PHKG2	4.58068383
4	PHKG1	4.58068383
5	PDK3	3.37069798
6	PDK4	3.37069798
7	MYLK	3.16578142
8	LMTK2	2.78892694
9	ZAK	2.57942697
10	MUSK	2.54393759
11	BCKDK	2.52140878
12	PINK1	2.46547582
13	PIK3CA	2.45909698
14	NEK1	2.43517319
15	DMPK	2.30150640
16	PDK2	2.06912325
17	STK24	2.00160796
18	NME1	1.82523065
19	CASK	1.79780204
20	FRK	1.73631612
21	TIE1	1.67957918
22	GRK7	1.67747349
23	MARK1	1.50489066
24	INSRR	1.43065189
25	PIK3CG	1.42444436
26	STK38L	1.34927895
27	PKN2	1.32336620
28	MAP2K3	1.28175992
29	MAP3K7	1.25967518
30	MAPK12	1.23655439
31	TRPM7	1.11963027
32	CAMK2D	1.05477914
33	PRKAA1	1.02879119
34	PRKAA2	0.94356658
35	SGK2	0.85733856
36	FLT3	0.84647377
37	BMPR1B	0.82789615
38	PKN1	0.81824170
39	ADRBK2	0.81389391
40	WNK3	0.80114863
41	ILK	0.80101879
42	DAPK2	0.78321685
43	MAP2K4	0.76815766
44	PRKD1	0.75824914
45	MAP2K7	0.73423084
46	LIMK1	0.72981403
47	STK4	0.72713716
48	OXSR1	0.70279584
49	PNCK	0.69440316
50	ROCK1	0.69385499
51	GRK1	0.68587183
52	CAMK4	0.68294501
53	TAOK2	0.64527798
54	CDC42BPA	0.64493280
55	SGK3	0.64207628
56	TRIB3	0.62375714
57	NLK	0.61867674
58	TNIK	0.61402225
59	MAP4K2	0.59487360
60	CAMK2A	0.57888981
61	PAK3	0.57713140
62	MAP3K5	0.56777289
63	NEK9	0.55308481
64	CCNB1	0.54000151
65	STK39	0.53414867
66	MAP2K6	0.52923133
67	PRKCE	0.52479523
68	CAMK1	0.52448882
69	PRKACB	0.51154189
70	CAMK2G	0.50038082
71	ACVR1B	0.49272278
72	AKT3	0.48880686
73	RPS6KC1	0.48295789
74	RPS6KL1	0.48295789
75	PRKACA	0.48106769
76	MAP2K1	0.48068473
77	MAPK7	0.46126595
78	MAP3K3	0.45649637
79	DAPK3	0.43527252
80	NUAK1	0.42665197
81	SGK1	0.38980505
82	CAMK2B	0.38940425
83	RPS6KA6	0.38589558
84	WNK1	0.38233530
85	TLK1	0.37458096
86	MAP3K4	0.36301384
87	STK38	0.35910560
88	PRKG1	0.35846268
89	AKT2	0.35685577
90	DYRK1B	0.35240308
91	IRAK3	0.34949122
92	SGK494	0.34659697
93	SGK223	0.34659697
94	PRPF4B	0.34620899
95	MAPKAPK3	0.33433973
96	CAMKK2	0.32976564
97	MAPK4	0.32820845
98	PRKACG	0.32348743
99	TAOK3	0.31659472
100	PTK2B	0.30969024
101	EPHA3	0.30107410
102	STK11	0.29994930
103	TGFBR2	0.29865853
104	WNK4	0.28939131
105	STK16	0.28882299
106	MAPK11	0.28396033
107	ERBB3	0.27952154
108	RPS6KB1	0.21836413
109	KDR	0.21519808
110	TNK2	0.19705895
111	EIF2AK2	0.19033052
112	PRKCQ	0.18396734
113	MOS	0.17206049
114	RIPK1	0.16253739
115	ROCK2	0.16162048
116	MKNK2	0.16123874
117	MAP3K12	0.15865291
118	DYRK2	0.15234284
119	RPS6KA3	0.15203677
120	NME2	0.13301488
121	LATS1	0.13295905
122	ADRBK1	0.12973164
123	RPS6KA2	0.12948683
124	PRKCH	0.12577128
125	TTK	0.12244427
126	PRKG2	0.12145526
127	MAPK15	0.12138540
128	TSSK6	0.11836454
129	PRKCG	0.11809854
130	CSNK1G1	0.11776546
131	MAPK13	0.09859924
132	RPS6KA1	0.09026728
133	PDK1	0.08334688
134	PRKCA	0.07634263
135	PLK2	0.06915595
136	CDK8	0.06310231

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	6.17343457
2	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	4.22806700
3	Cardiac muscle contraction_Homo sapiens_hsa04260	4.16624165
4	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	3.84589381
5	Dilated cardiomyopathy_Homo sapiens_hsa05414	3.63343473
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.54079315
7	Propanoate metabolism_Homo sapiens_hsa00640	3.42172084
8	Parkinsons disease_Homo sapiens_hsa05012	3.37311104
9	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.11102615
10	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.71155319
11	Fatty acid degradation_Homo sapiens_hsa00071	2.58398917
12	Alzheimers disease_Homo sapiens_hsa05010	2.53743660
13	Carbon metabolism_Homo sapiens_hsa01200	2.48285557
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.27762988
15	Huntingtons disease_Homo sapiens_hsa05016	2.17077260
16	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.13834687
17	Nitrogen metabolism_Homo sapiens_hsa00910	2.13797320
18	Pyruvate metabolism_Homo sapiens_hsa00620	1.98635846
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.95583126
20	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.50999980
21	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.49146488
22	Phototransduction_Homo sapiens_hsa04744	1.40816093
23	Fatty acid elongation_Homo sapiens_hsa00062	1.39773526
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35257006
25	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.34935946
26	Viral myocarditis_Homo sapiens_hsa05416	1.28580102
27	Glucagon signaling pathway_Homo sapiens_hsa04922	1.25086985
28	Circadian rhythm_Homo sapiens_hsa04710	1.22533418
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.16603773
30	Butanoate metabolism_Homo sapiens_hsa00650	1.16505145
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14598342
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.12173165
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.08758234
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.07960161
35	Insulin signaling pathway_Homo sapiens_hsa04910	1.04644697
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.03029605
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99192879
38	Insulin resistance_Homo sapiens_hsa04931	0.99091155
39	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98280826
40	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.93986403
41	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.92505816
42	Galactose metabolism_Homo sapiens_hsa00052	0.89853923
43	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.84248220
44	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.79694281
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79524365
46	PPAR signaling pathway_Homo sapiens_hsa03320	0.76071507
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74990819
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.74505587
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71217390
50	Salivary secretion_Homo sapiens_hsa04970	0.70038948
51	AMPK signaling pathway_Homo sapiens_hsa04152	0.68230335
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.66924248
53	GABAergic synapse_Homo sapiens_hsa04727	0.65670370
54	Peroxisome_Homo sapiens_hsa04146	0.65577437
55	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.63512306
56	Phenylalanine metabolism_Homo sapiens_hsa00360	0.59096708
57	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58267067
58	Arginine biosynthesis_Homo sapiens_hsa00220	0.57878724
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56832480
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53332855
61	Insulin secretion_Homo sapiens_hsa04911	0.52884141
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50689076
63	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.49732487
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.48506115
65	Serotonergic synapse_Homo sapiens_hsa04726	0.47730801
66	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.47151380
67	Metabolic pathways_Homo sapiens_hsa01100	0.46340512
68	Type II diabetes mellitus_Homo sapiens_hsa04930	0.45073328
69	Long-term depression_Homo sapiens_hsa04730	0.44404250
70	Renin secretion_Homo sapiens_hsa04924	0.43863830
71	Focal adhesion_Homo sapiens_hsa04510	0.43223358
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42638662
73	Histidine metabolism_Homo sapiens_hsa00340	0.41755179
74	Pancreatic secretion_Homo sapiens_hsa04972	0.41484146
75	Lysine degradation_Homo sapiens_hsa00310	0.40677083
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36775247
77	Nicotine addiction_Homo sapiens_hsa05033	0.36045993
78	Circadian entrainment_Homo sapiens_hsa04713	0.35836295
79	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.35591407
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34780381
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.33895975
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33398535
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.32509149
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.31571517
85	Tight junction_Homo sapiens_hsa04530	0.30764305
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30114290
87	Sulfur relay system_Homo sapiens_hsa04122	0.29931150
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29573672
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.29168892
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.28511552
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.28135337
92	Protein export_Homo sapiens_hsa03060	0.27896477
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.25131330
94	RNA polymerase_Homo sapiens_hsa03020	0.24538976
95	Taste transduction_Homo sapiens_hsa04742	0.22157757
96	Purine metabolism_Homo sapiens_hsa00230	0.21875216
97	Gastric acid secretion_Homo sapiens_hsa04971	0.20394314
98	FoxO signaling pathway_Homo sapiens_hsa04068	0.19033557
99	Olfactory transduction_Homo sapiens_hsa04740	0.17479979
100	Pentose phosphate pathway_Homo sapiens_hsa00030	0.17438757
101	Sulfur metabolism_Homo sapiens_hsa00920	0.17021389
102	Regulation of autophagy_Homo sapiens_hsa04140	0.15912697
103	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.15244889
104	Collecting duct acid secretion_Homo sapiens_hsa04966	0.12694603
105	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.11380849
106	ECM-receptor interaction_Homo sapiens_hsa04512	0.11097068
107	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.10050873
108	Morphine addiction_Homo sapiens_hsa05032	0.09277910
109	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.09240521
110	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.08613550
111	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.07026281
112	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.06742455
113	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.04079046
114	Caffeine metabolism_Homo sapiens_hsa00232	0.03665789
115	ABC transporters_Homo sapiens_hsa02010	0.03021479
116	Adherens junction_Homo sapiens_hsa04520	0.02611760
117	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.02584589
118	MAPK signaling pathway_Homo sapiens_hsa04010	0.01681513
119	GnRH signaling pathway_Homo sapiens_hsa04912	0.01038027
120	Amphetamine addiction_Homo sapiens_hsa05031	-0.1053421
121	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	-0.0802428
122	Inositol phosphate metabolism_Homo sapiens_hsa00562	-0.0680625
123	RNA degradation_Homo sapiens_hsa03018	-0.0536283
124	Cholinergic synapse_Homo sapiens_hsa04725	-0.0520412
125	Proteasome_Homo sapiens_hsa03050	-0.0391185
126	Amoebiasis_Homo sapiens_hsa05146	-0.0245060
127	Platelet activation_Homo sapiens_hsa04611	-0.0235725

KBTBD12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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