KBTBD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.49165237
2central nervous system myelination (GO:0022010)7.49165237
3fatty acid elongation (GO:0030497)5.31941743
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.25358094
5long-chain fatty acid biosynthetic process (GO:0042759)4.68609708
6presynaptic membrane assembly (GO:0097105)4.65438692
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56504077
8presynaptic membrane organization (GO:0097090)4.47529798
9ATP synthesis coupled proton transport (GO:0015986)4.42217176
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42217176
11respiratory electron transport chain (GO:0022904)4.25593739
12inositol phosphate catabolic process (GO:0071545)4.22797752
13inositol phosphate dephosphorylation (GO:0046855)4.19804832
14phosphorylated carbohydrate dephosphorylation (GO:0046838)4.19804832
15electron transport chain (GO:0022900)4.15283992
16chaperone-mediated protein transport (GO:0072321)4.06149967
17protein neddylation (GO:0045116)3.93508064
18myelination (GO:0042552)3.83060111
19ensheathment of neurons (GO:0007272)3.79976110
20axon ensheathment (GO:0008366)3.79976110
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.79370050
22negative regulation of neurotransmitter transport (GO:0051589)3.78040446
23negative regulation of neurotransmitter secretion (GO:0046929)3.74849282
24regulation of hexokinase activity (GO:1903299)3.71499570
25regulation of glucokinase activity (GO:0033131)3.71499570
26platelet dense granule organization (GO:0060155)3.70215222
27water-soluble vitamin biosynthetic process (GO:0042364)3.69094131
28protein complex biogenesis (GO:0070271)3.66525082
29signal peptide processing (GO:0006465)3.61374794
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.49234791
31NADH dehydrogenase complex assembly (GO:0010257)3.49234791
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49234791
33cellular ketone body metabolic process (GO:0046950)3.49199180
34substantia nigra development (GO:0021762)3.48768047
35GPI anchor biosynthetic process (GO:0006506)3.47444923
36neuronal action potential propagation (GO:0019227)3.38132643
37response to redox state (GO:0051775)3.37604778
38photoreceptor cell differentiation (GO:0046530)3.36818855
39eye photoreceptor cell differentiation (GO:0001754)3.36818855
40neuron cell-cell adhesion (GO:0007158)3.36248172
41DNA double-strand break processing (GO:0000729)3.27404214
42cholesterol biosynthetic process (GO:0006695)3.24869614
43mannosylation (GO:0097502)3.23947316
44GPI anchor metabolic process (GO:0006505)3.23157345
45respiratory chain complex IV assembly (GO:0008535)3.21741698
46response to pheromone (GO:0019236)3.19367742
47negative regulation of execution phase of apoptosis (GO:1900118)3.18935282
48positive regulation of oligodendrocyte differentiation (GO:0048714)3.18003740
49anterograde synaptic vesicle transport (GO:0048490)3.15448251
50polyol catabolic process (GO:0046174)3.14409196
51mitochondrial respiratory chain complex assembly (GO:0033108)3.13873562
52negative regulation of protein localization to cell surface (GO:2000009)3.12966974
53ketone body metabolic process (GO:1902224)3.09626725
54nucleotide transmembrane transport (GO:1901679)3.09063202
55proteasome assembly (GO:0043248)3.04342408
56regulation of collateral sprouting (GO:0048670)3.02562413
57ER overload response (GO:0006983)3.01311562
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.00070631
59nonmotile primary cilium assembly (GO:0035058)2.99429497
60sterol biosynthetic process (GO:0016126)2.97146348
61protein localization to cilium (GO:0061512)2.96536571
62regulation of cilium movement (GO:0003352)2.95396459
63maturation of 5.8S rRNA (GO:0000460)2.94628516
64insulin secretion (GO:0030073)2.93165253
65amyloid precursor protein metabolic process (GO:0042982)2.91680579
66C-terminal protein lipidation (GO:0006501)2.91670909
67oligodendrocyte differentiation (GO:0048709)2.90647167
68establishment of mitochondrion localization (GO:0051654)2.89022500
69C-terminal protein amino acid modification (GO:0018410)2.86060478
70preassembly of GPI anchor in ER membrane (GO:0016254)2.84835670
71hydrogen ion transmembrane transport (GO:1902600)2.83331415
72transmission of nerve impulse (GO:0019226)2.83044429
73epithelial cilium movement (GO:0003351)2.82970001
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81687415
75isoprenoid biosynthetic process (GO:0008299)2.81271583
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76875911
77limb bud formation (GO:0060174)2.75898482
78lactate metabolic process (GO:0006089)2.74864873
79intracellular protein transmembrane import (GO:0044743)2.74583309
80prenylation (GO:0097354)2.74257622
81protein prenylation (GO:0018342)2.74257622
82regulation of neuron projection regeneration (GO:0070570)2.74104867
83regulation of axon regeneration (GO:0048679)2.74104867
84regulation of dopamine metabolic process (GO:0042053)2.72380294
85regulation of catecholamine metabolic process (GO:0042069)2.72380294
86neurotransmitter uptake (GO:0001504)2.72284068
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72279151
88postsynaptic membrane organization (GO:0001941)2.71955956
89cellular response to epinephrine stimulus (GO:0071872)2.71704105
90proton transport (GO:0015992)2.71518464
91negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70903411
92positive regulation of action potential (GO:0045760)2.70806455
93regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.68833688
94response to methylmercury (GO:0051597)2.68772015
95cytochrome complex assembly (GO:0017004)2.68555551
96hydrogen transport (GO:0006818)2.67506207
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66746720
98peptidyl-cysteine modification (GO:0018198)2.66470371
99ATP hydrolysis coupled proton transport (GO:0015991)2.66232717
100energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.66232717
101magnesium ion transport (GO:0015693)2.65426278
102apical protein localization (GO:0045176)2.65321253
103DNA deamination (GO:0045006)2.65158139
104regulation of protein glycosylation (GO:0060049)2.63391922
105negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62334674
106protein localization to Golgi apparatus (GO:0034067)2.61966379
107endocrine pancreas development (GO:0031018)2.61623894
108glycerophospholipid catabolic process (GO:0046475)2.61382066
109indole-containing compound catabolic process (GO:0042436)2.60827005
110indolalkylamine catabolic process (GO:0046218)2.60827005
111tryptophan catabolic process (GO:0006569)2.60827005
112negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.59161794
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58184969
114regulation of mitotic spindle checkpoint (GO:1903504)2.58184969
115regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57467898
116branched-chain amino acid catabolic process (GO:0009083)2.56336144
117rhodopsin mediated signaling pathway (GO:0016056)2.55775346
118cilium morphogenesis (GO:0060271)2.55269356
119peroxisome fission (GO:0016559)2.54946234
120regulation of type B pancreatic cell apoptotic process (GO:2000674)2.54849098
121xenobiotic catabolic process (GO:0042178)2.54469088
122protein localization to synapse (GO:0035418)2.53496985
123membrane assembly (GO:0071709)2.52238301
124single strand break repair (GO:0000012)2.51676690
125calcium-mediated signaling using intracellular calcium source (GO:0035584)2.51520900
126cranial nerve development (GO:0021545)2.51174513
127myelin maintenance (GO:0043217)2.51103085
128peptidyl-histidine modification (GO:0018202)2.50100735
129termination of RNA polymerase III transcription (GO:0006386)2.49456297
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.49456297
131neural nucleus development (GO:0048857)2.49303263
132regulation of feeding behavior (GO:0060259)2.48465090
133adult walking behavior (GO:0007628)2.48204560
134cullin deneddylation (GO:0010388)2.47739717
135positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.46565294
136positive regulation of histone H3-K4 methylation (GO:0051571)2.45514940
137synaptic vesicle exocytosis (GO:0016079)2.45425416
138mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.45147092
139negative regulation of JUN kinase activity (GO:0043508)2.44777383
140protein polyglutamylation (GO:0018095)2.44715153
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43791477
142tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43791477
143ribonucleoprotein complex disassembly (GO:0032988)2.43579263
144response to epinephrine (GO:0071871)2.43356418
145detection of light stimulus involved in sensory perception (GO:0050962)2.43310469
146detection of light stimulus involved in visual perception (GO:0050908)2.43310469
147glycolipid biosynthetic process (GO:0009247)2.41553624
148positive regulation of insulin secretion (GO:0032024)2.41454800
149organelle disassembly (GO:1903008)2.40423072
150amyloid precursor protein catabolic process (GO:0042987)2.40067369
151aromatic amino acid family catabolic process (GO:0009074)2.39708418
152positive regulation of mitochondrial fission (GO:0090141)2.39631892
153dopamine biosynthetic process (GO:0042416)2.39213333
154protein targeting to Golgi (GO:0000042)2.38622244
155photoreceptor cell maintenance (GO:0045494)2.38588436
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38077189
157positive regulation of amino acid transport (GO:0051957)2.37877389
158negative regulation of membrane potential (GO:0045837)2.37072395
159neuron remodeling (GO:0016322)2.36624620
160DNA integration (GO:0015074)2.36315872
161transferrin transport (GO:0033572)2.35993865
162cilium organization (GO:0044782)2.35644877
163aldehyde catabolic process (GO:0046185)2.35492567
164inner mitochondrial membrane organization (GO:0007007)2.35143253
165establishment of protein localization to Golgi (GO:0072600)2.33890643
166intraciliary transport (GO:0042073)2.33631433
167long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.32956846
168cerebral cortex radially oriented cell migration (GO:0021799)2.32137322
169retina layer formation (GO:0010842)2.30491292
170GTP biosynthetic process (GO:0006183)2.30477903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.72745891
2TAF15_26573619_Chip-Seq_HEK293_Human3.15065281
3EZH2_22144423_ChIP-Seq_EOC_Human3.12393304
4EST1_17652178_ChIP-ChIP_JURKAT_Human2.67155259
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58726451
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47269085
7ZNF274_21170338_ChIP-Seq_K562_Hela2.45192990
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40367608
9ELK1_19687146_ChIP-ChIP_HELA_Human2.20883993
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19075820
11VDR_22108803_ChIP-Seq_LS180_Human2.15926553
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14697570
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12889074
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.12007554
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06597637
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04727767
17IGF1R_20145208_ChIP-Seq_DFB_Human2.01168017
18FUS_26573619_Chip-Seq_HEK293_Human1.98026971
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.96359779
20P300_19829295_ChIP-Seq_ESCs_Human1.91565734
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.90945413
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89146353
23ER_23166858_ChIP-Seq_MCF-7_Human1.88830964
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83121692
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.81664036
26VDR_23849224_ChIP-Seq_CD4+_Human1.81505019
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.80326907
28AR_21572438_ChIP-Seq_LNCaP_Human1.79845641
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78482302
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77528574
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74442960
32* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72302964
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68996544
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67919659
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64960087
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64708602
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.61957491
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61209147
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60985299
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60985299
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.60825274
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57893845
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56654359
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56186501
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54669017
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52884931
47* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50119307
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.48126001
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47325706
50BCAT_22108803_ChIP-Seq_LS180_Human1.46541966
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.46340449
52* AR_25329375_ChIP-Seq_VCAP_Human1.45417666
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44918301
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44893584
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44674448
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44653397
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44619229
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.42911252
59* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42295907
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.40410300
61SMAD4_21799915_ChIP-Seq_A2780_Human1.40120514
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39214405
63CBP_20019798_ChIP-Seq_JUKART_Human1.39214405
64RNF2_27304074_Chip-Seq_NSC_Mouse1.39167457
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.39023569
66TP53_22573176_ChIP-Seq_HFKS_Human1.38947028
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.38705074
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36911094
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33881816
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33625502
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33463719
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33251570
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.33210419
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32630137
75MYC_18940864_ChIP-ChIP_HL60_Human1.31697149
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30998136
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30759854
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30351494
79* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29751511
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.29079058
81REST_21632747_ChIP-Seq_MESCs_Mouse1.29004272
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28595946
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28322047
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.27862850
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.27186598
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26310957
87* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26235568
88P300_18555785_Chip-Seq_ESCs_Mouse1.25985690
89FOXP3_21729870_ChIP-Seq_TREG_Human1.25860697
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.25676664
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25676664
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25298369
93P53_22387025_ChIP-Seq_ESCs_Mouse1.24968550
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24179748
95TCF4_22108803_ChIP-Seq_LS180_Human1.23861162
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.23009786
97GABP_17652178_ChIP-ChIP_JURKAT_Human1.21652279
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21519997
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.21370759
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20761151
101STAT3_18555785_Chip-Seq_ESCs_Mouse1.20654087
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18861741
103EWS_26573619_Chip-Seq_HEK293_Human1.18283560
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17605242
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.16150817
106IRF1_19129219_ChIP-ChIP_H3396_Human1.15681575
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14914676
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14835597
109NANOG_19829295_ChIP-Seq_ESCs_Human1.14742405
110SOX2_19829295_ChIP-Seq_ESCs_Human1.14742405
111HTT_18923047_ChIP-ChIP_STHdh_Human1.14469093
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13956230
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12582788
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12220306
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.11985629
116CDX2_22108803_ChIP-Seq_LS180_Human1.11847866
117AR_20517297_ChIP-Seq_VCAP_Human1.10978035
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10569925
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10131915
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09603273
121NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09603273
122STAT3_23295773_ChIP-Seq_U87_Human1.09394496
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.09028814
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08179551
125JUN_21703547_ChIP-Seq_K562_Human1.06997178
126NMYC_18555785_Chip-Seq_ESCs_Mouse1.06488347
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05704635
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05418435
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04686462
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.04601000
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.04312676
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02985864
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02548376
134SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02472547
135RUNX2_22187159_ChIP-Seq_PCA_Human1.02322971
136TCF4_23295773_ChIP-Seq_U87_Human1.02070694
137KDM2B_26808549_Chip-Seq_REH_Human1.01539045
138KLF4_18555785_Chip-Seq_ESCs_Mouse1.01030926
139WT1_19549856_ChIP-ChIP_CCG9911_Human1.00766132
140OCT4_18555785_Chip-Seq_ESCs_Mouse1.00539696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.51321077
2MP0000920_abnormal_myelination3.14584893
3MP0009780_abnormal_chondrocyte_physiolo3.08706239
4MP0003011_delayed_dark_adaptation3.03684955
5MP0001529_abnormal_vocalization3.00811087
6MP0004270_analgesia2.84492126
7MP0008877_abnormal_DNA_methylation2.70922012
8MP0001986_abnormal_taste_sensitivity2.63012999
9MP0002272_abnormal_nervous_system2.60908524
10MP0001905_abnormal_dopamine_level2.51340303
11MP0003136_yellow_coat_color2.45172254
12MP0002734_abnormal_mechanical_nocicepti2.29072901
13MP0002064_seizures2.24655989
14MP0001486_abnormal_startle_reflex2.21426215
15MP0005084_abnormal_gallbladder_morpholo2.17834134
16MP0004142_abnormal_muscle_tone2.17760059
17MP0005171_absent_coat_pigmentation2.15060781
18MP0005379_endocrine/exocrine_gland_phen2.13869558
19MP0001968_abnormal_touch/_nociception2.11392125
20MP0002909_abnormal_adrenal_gland2.11331173
21MP0009745_abnormal_behavioral_response2.10498175
22MP0005551_abnormal_eye_electrophysiolog2.09976672
23MP0005409_darkened_coat_color1.99889982
24MP0009046_muscle_twitch1.99489996
25MP0006072_abnormal_retinal_apoptosis1.96447555
26MP0003635_abnormal_synaptic_transmissio1.94043523
27MP0009379_abnormal_foot_pigmentation1.86202988
28MP0010386_abnormal_urinary_bladder1.83752649
29MP0005423_abnormal_somatic_nervous1.83061885
30MP0002736_abnormal_nociception_after1.82826038
31MP0006276_abnormal_autonomic_nervous1.81335058
32MP0004742_abnormal_vestibular_system1.81193636
33MP0003950_abnormal_plasma_membrane1.80477058
34MP0004147_increased_porphyrin_level1.79749672
35MP0001984_abnormal_olfaction1.79510288
36MP0001188_hyperpigmentation1.71712385
37MP0002572_abnormal_emotion/affect_behav1.70860704
38MP0002638_abnormal_pupillary_reflex1.68416896
39MP0002067_abnormal_sensory_capabilities1.66149661
40MP0001970_abnormal_pain_threshold1.64607019
41MP0000778_abnormal_nervous_system1.62618154
42MP0001440_abnormal_grooming_behavior1.62168650
43MP0002163_abnormal_gland_morphology1.60718717
44MP0002229_neurodegeneration1.60288103
45MP0002735_abnormal_chemical_nociception1.59296944
46MP0002254_reproductive_system_inflammat1.58403061
47MP0004859_abnormal_synaptic_plasticity1.58024673
48MP0008058_abnormal_DNA_repair1.57132384
49MP0002063_abnormal_learning/memory/cond1.53189608
50MP0005645_abnormal_hypothalamus_physiol1.51652845
51MP0008875_abnormal_xenobiotic_pharmacok1.50286402
52MP0005253_abnormal_eye_physiology1.48662207
53MP0004043_abnormal_pH_regulation1.48286573
54MP0001485_abnormal_pinna_reflex1.47893534
55MP0003634_abnormal_glial_cell1.46416069
56MP0002837_dystrophic_cardiac_calcinosis1.44209750
57MP0001944_abnormal_pancreas_morphology1.42091244
58MP0002733_abnormal_thermal_nociception1.41941978
59MP0001502_abnormal_circadian_rhythm1.38934315
60MP0003329_amyloid_beta_deposits1.37626781
61MP0003121_genomic_imprinting1.37562001
62MP0000372_irregular_coat_pigmentation1.37310579
63MP0000427_abnormal_hair_cycle1.34384804
64MP0002693_abnormal_pancreas_physiology1.32959177
65MP0005332_abnormal_amino_acid1.30774474
66MP0005646_abnormal_pituitary_gland1.30307735
67MP0006035_abnormal_mitochondrial_morpho1.29091889
68MP0005410_abnormal_fertilization1.28170227
69MP0008569_lethality_at_weaning1.27835098
70MP0008872_abnormal_physiological_respon1.27436356
71MP0008260_abnormal_autophagy1.26086156
72MP0003690_abnormal_glial_cell1.25183344
73MP0001963_abnormal_hearing_physiology1.24763851
74MP0003787_abnormal_imprinting1.24418236
75MP0002822_catalepsy1.23831512
76MP0002882_abnormal_neuron_morphology1.23604721
77MP0005220_abnormal_exocrine_pancreas1.23275838
78MP0004924_abnormal_behavior1.22822825
79MP0005386_behavior/neurological_phenoty1.22822825
80MP0005367_renal/urinary_system_phenotyp1.22150184
81MP0000516_abnormal_urinary_system1.22150184
82MP0002184_abnormal_innervation1.21326068
83MP0006292_abnormal_olfactory_placode1.19694607
84MP0002102_abnormal_ear_morphology1.19003306
85MP0002876_abnormal_thyroid_physiology1.18661450
86MP0000955_abnormal_spinal_cord1.17590405
87MP0004145_abnormal_muscle_electrophysio1.15951369
88MP0002752_abnormal_somatic_nervous1.15786466
89MP0002139_abnormal_hepatobiliary_system1.13924984
90MP0006054_spinal_hemorrhage1.12167155
91MP0002557_abnormal_social/conspecific_i1.09580903
92MP0003806_abnormal_nucleotide_metabolis1.09213181
93MP0005167_abnormal_blood-brain_barrier1.09202985
94MP0000013_abnormal_adipose_tissue1.08762138
95MP0002066_abnormal_motor_capabilities/c1.07375389
96MP0004381_abnormal_hair_follicle1.07075629
97MP0004019_abnormal_vitamin_homeostasis1.06925568
98MP0005636_abnormal_mineral_homeostasis1.05277690
99MP0002078_abnormal_glucose_homeostasis1.04755149
100MP0000566_synostosis1.01931223
101MP0005195_abnormal_posterior_eye1.01320151
102MP0002928_abnormal_bile_duct1.00347798
103MP0010234_abnormal_vibrissa_follicle0.99879916
104MP0004134_abnormal_chest_morphology0.98968626
105MP0003186_abnormal_redox_activity0.95038259
106MP0002090_abnormal_vision0.94094867
107MP0005389_reproductive_system_phenotype0.93575797
108MP0001501_abnormal_sleep_pattern0.93288222
109MP0003631_nervous_system_phenotype0.93283247
110MP0003633_abnormal_nervous_system0.92754961
111MP0008789_abnormal_olfactory_epithelium0.91154508
112MP0000026_abnormal_inner_ear0.90898194
113MP0003632_abnormal_nervous_system0.89802929
114MP0002160_abnormal_reproductive_system0.89791024
115MP0000015_abnormal_ear_pigmentation0.89221396
116MP0004885_abnormal_endolymph0.88769451
117MP0001756_abnormal_urination0.87558176
118MP0003122_maternal_imprinting0.87057572
119MP0004215_abnormal_myocardial_fiber0.86938774
120MP0010329_abnormal_lipoprotein_level0.86811598
121MP0003718_maternal_effect0.85708879
122MP0005408_hypopigmentation0.85452592
123MP0003195_calcinosis0.84710425
124MP0008995_early_reproductive_senescence0.83219637
125MP0001919_abnormal_reproductive_system0.82384543
126MP0000631_abnormal_neuroendocrine_gland0.81673780
127MP0000639_abnormal_adrenal_gland0.79132807
128MP0009697_abnormal_copulation0.78785014
129MP0001764_abnormal_homeostasis0.78755747
130MP0003953_abnormal_hormone_level0.77740061
131MP0001664_abnormal_digestion0.77523324
132MP0003137_abnormal_impulse_conducting0.73579463
133MP0006036_abnormal_mitochondrial_physio0.73247595
134MP0004036_abnormal_muscle_relaxation0.69687324
135MP0002938_white_spotting0.66343970
136MP0005310_abnormal_salivary_gland0.64083816
137MP0002277_abnormal_respiratory_mucosa0.62749436
138MP0004085_abnormal_heartbeat0.62219066
139MP0005394_taste/olfaction_phenotype0.62077407
140MP0005499_abnormal_olfactory_system0.62077407
141MP0000230_abnormal_systemic_arterial0.59328115
142MP0004484_altered_response_of0.59236055

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87673627
2Abnormal mitochondria in muscle tissue (HP:0008316)4.40433246
3Mitochondrial inheritance (HP:0001427)4.36057991
4Progressive macrocephaly (HP:0004481)4.10769598
5Increased hepatocellular lipid droplets (HP:0006565)3.96374052
6Hyperinsulinemic hypoglycemia (HP:0000825)3.90451278
7Acute encephalopathy (HP:0006846)3.88923211
8Renal Fanconi syndrome (HP:0001994)3.84927242
9Neurofibrillary tangles (HP:0002185)3.75797406
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.74609366
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.74609366
12Hypoglycemic coma (HP:0001325)3.69065766
13Hepatocellular necrosis (HP:0001404)3.67411751
14Increased CSF lactate (HP:0002490)3.57108888
15Lipid accumulation in hepatocytes (HP:0006561)3.51109207
16Parakeratosis (HP:0001036)3.48919168
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.41845524
18Hypoglycemic seizures (HP:0002173)3.30650814
19Sensory axonal neuropathy (HP:0003390)3.29423161
20Leukodystrophy (HP:0002415)3.25743736
21Renal cortical cysts (HP:0000803)3.20513254
22Ketoacidosis (HP:0001993)3.19890944
23Abnormality of glycolysis (HP:0004366)3.14622478
24Increased serum pyruvate (HP:0003542)3.14622478
25Medial flaring of the eyebrow (HP:0010747)3.06027673
26Methylmalonic aciduria (HP:0012120)3.04949850
27Hepatic necrosis (HP:0002605)2.99387309
28Focal motor seizures (HP:0011153)2.98746619
29Abnormality of vitamin B metabolism (HP:0004340)2.98659739
30Atonic seizures (HP:0010819)2.95593704
31Retinal dysplasia (HP:0007973)2.92300361
32Gait imbalance (HP:0002141)2.91558168
33Optic disc pallor (HP:0000543)2.90224016
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.88188623
35Neuroendocrine neoplasm (HP:0100634)2.88174102
36Pancreatic cysts (HP:0001737)2.82860416
37Vaginal atresia (HP:0000148)2.80726253
38Pancreatic fibrosis (HP:0100732)2.80630376
39Congenital primary aphakia (HP:0007707)2.78547768
40Nephrogenic diabetes insipidus (HP:0009806)2.78326238
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77611194
42Genital tract atresia (HP:0001827)2.77097292
43Hyperglycemia (HP:0003074)2.73181709
44Increased intramyocellular lipid droplets (HP:0012240)2.73003738
45Abnormality of urine glucose concentration (HP:0011016)2.70616516
46Glycosuria (HP:0003076)2.70616516
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70092704
48Abnormality of renal resorption (HP:0011038)2.67173555
49Pheochromocytoma (HP:0002666)2.64282161
50Hypothermia (HP:0002045)2.64163634
51Abnormality of midbrain morphology (HP:0002418)2.62843669
52Molar tooth sign on MRI (HP:0002419)2.62843669
533-Methylglutaconic aciduria (HP:0003535)2.60170309
54Large for gestational age (HP:0001520)2.56429171
55Abnormality of the renal cortex (HP:0011035)2.56314269
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56287575
57True hermaphroditism (HP:0010459)2.55206466
58Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54492521
59Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54492521
60Abnormality of methionine metabolism (HP:0010901)2.48761903
61Cerebral hypomyelination (HP:0006808)2.45286073
62Intestinal atresia (HP:0011100)2.43717094
63Peripheral hypomyelination (HP:0007182)2.42353671
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.41322606
65Respiratory failure (HP:0002878)2.40399063
66Abnormality of the corticospinal tract (HP:0002492)2.38582827
67Cerebral inclusion bodies (HP:0100314)2.38465678
68Nephronophthisis (HP:0000090)2.35783955
69Exertional dyspnea (HP:0002875)2.32126318
70Epileptic encephalopathy (HP:0200134)2.31451957
71Exercise intolerance (HP:0003546)2.30632078
72Cerebral edema (HP:0002181)2.23124727
73Aplasia/hypoplasia of the uterus (HP:0008684)2.22687377
74Abnormality of the pancreatic islet cells (HP:0006476)2.21986618
75Abnormality of endocrine pancreas physiology (HP:0012093)2.21986618
76Prominent metopic ridge (HP:0005487)2.20972116
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20745359
78Methylmalonic acidemia (HP:0002912)2.20413380
79X-linked dominant inheritance (HP:0001423)2.18821621
80Ketosis (HP:0001946)2.18013306
81Hypomagnesemia (HP:0002917)2.16353621
82Increased muscle lipid content (HP:0009058)2.15535095
83Congenital ichthyosiform erythroderma (HP:0007431)2.15109866
84Pancreatic islet-cell hyperplasia (HP:0004510)2.13978841
85Abnormality of the metopic suture (HP:0005556)2.13536087
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11977560
87Abnormal hair whorl (HP:0010721)2.11796548
88Muscular hypotonia of the trunk (HP:0008936)2.11343988
89Abnormal ciliary motility (HP:0012262)2.10032311
90Supranuclear gaze palsy (HP:0000605)2.08573982
91Dysmetria (HP:0001310)2.08398350
92Lactic acidosis (HP:0003128)2.08200468
93Symptomatic seizures (HP:0011145)2.05582664
94Hyperphosphaturia (HP:0003109)2.04990971
95Scanning speech (HP:0002168)2.04135932
96Increased serum lactate (HP:0002151)2.03262952
97Congenital, generalized hypertrichosis (HP:0004540)2.02932879
98Abnormality of the renal medulla (HP:0100957)2.02510970
99Alacrima (HP:0000522)2.01735600
100Hypoplastic pelvis (HP:0008839)2.01633464
101EEG with generalized epileptiform discharges (HP:0011198)1.99893202
102Abnormality of vitamin metabolism (HP:0100508)1.99643327
103Abnormal pupillary function (HP:0007686)1.99617915
104Absent/shortened dynein arms (HP:0200106)1.99459137
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.99459137
106Split foot (HP:0001839)1.98806076
107Tubulointerstitial nephritis (HP:0001970)1.98502675
108Hemiparesis (HP:0001269)1.98219097
109Epileptiform EEG discharges (HP:0011182)1.98062808
110Lethargy (HP:0001254)1.95280533
111Respiratory difficulties (HP:0002880)1.95125900
112Cerebral hemorrhage (HP:0001342)1.93742609
113Abnormal respiratory motile cilium physiology (HP:0012261)1.93534751
114Patchy hypopigmentation of hair (HP:0011365)1.93041436
115Thickened helices (HP:0000391)1.92796503
116Neoplasm of the adrenal gland (HP:0100631)1.92352594
117Abnormality of macular pigmentation (HP:0008002)1.91463601
118Hyperventilation (HP:0002883)1.90839846
119Hypsarrhythmia (HP:0002521)1.90627102
120Insulin-resistant diabetes mellitus (HP:0000831)1.90609705
121Clumsiness (HP:0002312)1.89808965
122Congenital sensorineural hearing impairment (HP:0008527)1.89654190
123Dicarboxylic aciduria (HP:0003215)1.88145506
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88145506
125Attenuation of retinal blood vessels (HP:0007843)1.87247192
126Poor coordination (HP:0002370)1.86811435
127Myokymia (HP:0002411)1.85395535
128Type II lissencephaly (HP:0007260)1.84519093
129Spastic gait (HP:0002064)1.84307506
130Furrowed tongue (HP:0000221)1.83570397
131Poor suck (HP:0002033)1.82868931
132Decreased lacrimation (HP:0000633)1.82611775
133Dialeptic seizures (HP:0011146)1.82165104
134Renal tubular dysfunction (HP:0000124)1.82109714
135Febrile seizures (HP:0002373)1.81924236
136Generalized aminoaciduria (HP:0002909)1.81432562
137Palpitations (HP:0001962)1.80051363
138Progressive inability to walk (HP:0002505)1.78471584
139Absent septum pellucidum (HP:0001331)1.78257998
140Aplasia/Hypoplasia of the lens (HP:0008063)1.77925002
141Intention tremor (HP:0002080)1.77256895
142Gaze-evoked nystagmus (HP:0000640)1.76174944
143Autoamputation (HP:0001218)1.75461156
144Short tibia (HP:0005736)1.74192316
145Adrenal hypoplasia (HP:0000835)1.73560984
146Polydipsia (HP:0001959)1.73556850
147Abnormal drinking behavior (HP:0030082)1.73556850
148Abnormal rod and cone electroretinograms (HP:0008323)1.73236015
149Disproportionate short-trunk short stature (HP:0003521)1.72318790
150Limb dystonia (HP:0002451)1.72207541
151Congenital stationary night blindness (HP:0007642)1.71182420
152Cupped ear (HP:0000378)1.71150760
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.69746221
154Metaphyseal dysplasia (HP:0100255)1.69677259
155Absence seizures (HP:0002121)1.66819754
156Anxiety (HP:0000739)1.66575963
157White forelock (HP:0002211)1.65972707
158Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65147574
159CNS hypomyelination (HP:0003429)1.63546242
160Humeroradial synostosis (HP:0003041)1.62813336
161Synostosis involving the elbow (HP:0003938)1.62813336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.31308481
2MAP4K23.98245276
3CASK3.86815541
4PBK3.27851705
5OXSR13.21312088
6TRIM282.61156131
7BCR2.60724265
8TNIK2.51137548
9PINK12.47156810
10CDK192.14568568
11ERBB32.13848782
12MAPKAPK52.10932495
13PRPF4B2.00070890
14WNK41.99675810
15MUSK1.97301695
16MAP2K71.96574401
17NUAK11.84899013
18BMPR1B1.84705237
19EPHA41.79939034
20NEK61.74952876
21MAP3K121.74364296
22MST41.71584544
23PKN11.67396511
24EIF2AK11.65355869
25BMPR21.64015490
26STK161.54329926
27CAMK2B1.48176574
28PASK1.47411276
29UHMK11.40253762
30CAMK2D1.34897110
31STK38L1.32812843
32LIMK11.31482356
33DAPK21.27841890
34GRK71.26246841
35IRAK21.25594591
36ARAF1.24015653
37FGR1.23669940
38VRK21.23532978
39NME11.22766187
40MAPK151.22277188
41ADRBK21.19293510
42WNK11.19192328
43TAF11.18194719
44NTRK31.16883919
45ACVR1B1.16094959
46CSNK1G31.16038563
47PNCK1.13514671
48PRKCE1.12611720
49SGK4941.12155760
50SGK2231.12155760
51CAMK2A1.10597969
52IRAK11.09685048
53DYRK21.08097180
54MAPK131.07893403
55MAP3K41.05453348
56PLK31.03829297
57FES1.00240706
58CAMK2G0.99632598
59NTRK10.99397047
60EPHB10.95477424
61FGFR20.93289697
62MET0.92844807
63ROCK20.92313293
64CSNK1A1L0.88819837
65AKT30.88339737
66MYLK0.87675867
67BRSK20.86727644
68FER0.84506491
69PIK3CA0.81759553
70PRKCQ0.81759127
71CSNK1G20.79549350
72PLK20.79043515
73CSNK1G10.78469468
74DAPK10.77160795
75MKNK10.75470576
76IRAK40.75046781
77NLK0.72875140
78INSRR0.72534402
79EPHA30.72067085
80PHKG10.71891256
81PHKG20.71891256
82MAP3K90.69850357
83TXK0.69757050
84STK30.69140122
85TAOK30.69019312
86MARK10.67397021
87CLK10.66311098
88TSSK60.65866444
89TEC0.64075137
90BCKDK0.64004366
91SRPK10.63713996
92GRK50.61860421
93CDK50.61473536
94OBSCN0.61279099
95CDK140.59929428
96CDK30.59186304
97MINK10.58121584
98EIF2AK30.58078313
99GRK10.57959950
100DYRK1A0.56386128
101MKNK20.55942618
102VRK10.55545080
103HIPK20.54507994
104MARK20.53794696
105WNK30.53317071
106RPS6KA50.52558200
107PRKACA0.52547277
108CDK180.51540840
109RIPK40.50857258
110NEK10.49600466
111CCNB10.49283591
112ADRBK10.48476915
113YES10.47986869
114TRPM70.47565465
115CDK150.47327942
116STK240.47289520
117MAP3K20.46530564
118PLK40.46139929
119PRKG10.46098685
120DYRK30.45197131
121CDK80.44343824
122MAP2K60.44019449
123RPS6KA40.42146930
124ZAK0.41347763
125CDK11A0.41331331
126TLK10.40245514
127PRKCG0.38669629
128SIK30.37818286
129PAK30.37697946
130EIF2AK20.37690402
131TESK20.36563904
132IKBKE0.36542239
133PRKCI0.34919369
134MAP3K130.34824981
135CSNK1A10.34254773
136TNK20.33905100
137MAP3K140.32635123
138TIE10.32464278
139ATM0.31261261
140CSNK2A20.31218080
141ITK0.30959080
142CSNK1D0.30698020
143CAMKK20.28956742
144PRKCA0.27972624
145FRK0.27591303
146PDK20.26384879

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.60015292
2Protein export_Homo sapiens_hsa030603.81071013
3Parkinsons disease_Homo sapiens_hsa050123.53330702
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.25215652
5Alzheimers disease_Homo sapiens_hsa050103.07182883
6Fatty acid elongation_Homo sapiens_hsa000622.92652289
7Caffeine metabolism_Homo sapiens_hsa002322.65429657
8Steroid biosynthesis_Homo sapiens_hsa001002.49522282
9Collecting duct acid secretion_Homo sapiens_hsa049662.48075844
10Huntingtons disease_Homo sapiens_hsa050162.45498999
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35253786
12Ether lipid metabolism_Homo sapiens_hsa005652.24663731
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12715489
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04910879
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02606865
16Nicotine addiction_Homo sapiens_hsa050332.01985151
17Vibrio cholerae infection_Homo sapiens_hsa051101.97941042
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85651263
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.83763549
20Phototransduction_Homo sapiens_hsa047441.82205942
21Serotonergic synapse_Homo sapiens_hsa047261.80312745
22Sulfur metabolism_Homo sapiens_hsa009201.80139935
23GABAergic synapse_Homo sapiens_hsa047271.77642313
24Cardiac muscle contraction_Homo sapiens_hsa042601.75354077
25Synaptic vesicle cycle_Homo sapiens_hsa047211.70275973
26Sphingolipid metabolism_Homo sapiens_hsa006001.70161365
27Morphine addiction_Homo sapiens_hsa050321.62144093
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53661695
29Peroxisome_Homo sapiens_hsa041461.45239756
30Glutamatergic synapse_Homo sapiens_hsa047241.39120386
31RNA degradation_Homo sapiens_hsa030181.39116823
32Taste transduction_Homo sapiens_hsa047421.35931688
33Rheumatoid arthritis_Homo sapiens_hsa053231.30423443
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28199821
35Circadian entrainment_Homo sapiens_hsa047131.25219524
36Proteasome_Homo sapiens_hsa030501.23936472
37Nitrogen metabolism_Homo sapiens_hsa009101.22970853
38Tryptophan metabolism_Homo sapiens_hsa003801.20113292
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18465601
40Homologous recombination_Homo sapiens_hsa034401.16106660
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11684950
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10692669
43Insulin secretion_Homo sapiens_hsa049111.09808547
44Circadian rhythm_Homo sapiens_hsa047101.09470154
45Linoleic acid metabolism_Homo sapiens_hsa005911.08622880
46Selenocompound metabolism_Homo sapiens_hsa004501.07714468
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.07288516
48Dopaminergic synapse_Homo sapiens_hsa047281.03965241
49RNA polymerase_Homo sapiens_hsa030201.02803384
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.98481356
51Ribosome_Homo sapiens_hsa030100.96574351
52Arachidonic acid metabolism_Homo sapiens_hsa005900.96408651
53Chemical carcinogenesis_Homo sapiens_hsa052040.95678779
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94217897
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94047952
56Cholinergic synapse_Homo sapiens_hsa047250.91671937
57Long-term depression_Homo sapiens_hsa047300.90084470
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89519789
59Renin secretion_Homo sapiens_hsa049240.86044063
60Retinol metabolism_Homo sapiens_hsa008300.85959580
61Cocaine addiction_Homo sapiens_hsa050300.84575746
62Fatty acid metabolism_Homo sapiens_hsa012120.82291990
63Phagosome_Homo sapiens_hsa041450.81643405
64Vitamin B6 metabolism_Homo sapiens_hsa007500.81433051
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80838588
66Amphetamine addiction_Homo sapiens_hsa050310.80702135
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80043887
68Fatty acid degradation_Homo sapiens_hsa000710.79782747
69Histidine metabolism_Homo sapiens_hsa003400.79476976
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78634577
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78060731
72Axon guidance_Homo sapiens_hsa043600.77195851
73Olfactory transduction_Homo sapiens_hsa047400.76405670
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76044652
75beta-Alanine metabolism_Homo sapiens_hsa004100.76043430
76Salivary secretion_Homo sapiens_hsa049700.73668917
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73236531
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73100416
79Nucleotide excision repair_Homo sapiens_hsa034200.70059923
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69493301
81Regulation of autophagy_Homo sapiens_hsa041400.68423640
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68212669
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65351318
84Long-term potentiation_Homo sapiens_hsa047200.62314215
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.62033944
86Metabolic pathways_Homo sapiens_hsa011000.61463318
87Folate biosynthesis_Homo sapiens_hsa007900.61090483
88Pancreatic secretion_Homo sapiens_hsa049720.60522423
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58799266
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.58709997
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58485064
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.58347237
93Calcium signaling pathway_Homo sapiens_hsa040200.57888904
94Other glycan degradation_Homo sapiens_hsa005110.56151444
95Butanoate metabolism_Homo sapiens_hsa006500.54712657
96Fanconi anemia pathway_Homo sapiens_hsa034600.53645488
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.52148442
98Autoimmune thyroid disease_Homo sapiens_hsa053200.50847843
99Mismatch repair_Homo sapiens_hsa034300.50549587
100Oocyte meiosis_Homo sapiens_hsa041140.50545538
101Pyrimidine metabolism_Homo sapiens_hsa002400.50388512
102Gastric acid secretion_Homo sapiens_hsa049710.48633664
103N-Glycan biosynthesis_Homo sapiens_hsa005100.46003719
104Basal transcription factors_Homo sapiens_hsa030220.44154714
105ABC transporters_Homo sapiens_hsa020100.43663114
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43089487
107Lysosome_Homo sapiens_hsa041420.42743355
108Pyruvate metabolism_Homo sapiens_hsa006200.42519728
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42426173
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.41339782
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40778679
112cAMP signaling pathway_Homo sapiens_hsa040240.38348964
113Arginine and proline metabolism_Homo sapiens_hsa003300.36430511
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36319961
115Ras signaling pathway_Homo sapiens_hsa040140.36119046
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34628638
117Purine metabolism_Homo sapiens_hsa002300.34606956
118Alcoholism_Homo sapiens_hsa050340.33980163
119Propanoate metabolism_Homo sapiens_hsa006400.32133909
120Type I diabetes mellitus_Homo sapiens_hsa049400.31913082
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31677218
122Mineral absorption_Homo sapiens_hsa049780.31202904
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.30827819
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.29661414
125Oxytocin signaling pathway_Homo sapiens_hsa049210.29173205
126Non-homologous end-joining_Homo sapiens_hsa034500.28210875
127Tyrosine metabolism_Homo sapiens_hsa003500.26051036
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23149442
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.22818477
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22791338
131Glutathione metabolism_Homo sapiens_hsa004800.22752672
132Ovarian steroidogenesis_Homo sapiens_hsa049130.21337387
133Gap junction_Homo sapiens_hsa045400.18272664
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16891962
135GnRH signaling pathway_Homo sapiens_hsa049120.16764973
136Thyroid hormone synthesis_Homo sapiens_hsa049180.14753812
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14403281

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