KBTBD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)5.66526393
2negative regulation of cell aging (GO:0090344)4.76281683
3meiotic chromosome segregation (GO:0045132)4.67035286
4NADH metabolic process (GO:0006734)4.46754956
5nucleobase biosynthetic process (GO:0046112)4.40404319
6mitotic metaphase plate congression (GO:0007080)4.37689873
7N-acetylneuraminate metabolic process (GO:0006054)4.30930946
8proteasome assembly (GO:0043248)4.22277669
9purine nucleobase biosynthetic process (GO:0009113)4.17919756
10GDP-mannose metabolic process (GO:0019673)4.16508253
11DNA deamination (GO:0045006)4.15128797
12rRNA methylation (GO:0031167)4.14016159
13rRNA modification (GO:0000154)4.11706241
14tricarboxylic acid cycle (GO:0006099)4.06200798
15oxaloacetate metabolic process (GO:0006107)4.02416234
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.93797764
17cullin deneddylation (GO:0010388)3.93057554
18regulation of protein heterodimerization activity (GO:0043497)3.92194150
19regulation of cytokine production involved in inflammatory response (GO:1900015)3.90797177
20protein deneddylation (GO:0000338)3.87151011
21ribosomal small subunit assembly (GO:0000028)3.86719223
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.86403484
23regulation of skeletal muscle contraction (GO:0014819)3.78020733
24respiratory chain complex IV assembly (GO:0008535)3.75160509
25regulation of oxidative phosphorylation (GO:0002082)3.73061338
26metaphase plate congression (GO:0051310)3.70911328
27DNA strand elongation involved in DNA replication (GO:0006271)3.68180060
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.66743711
29NADH dehydrogenase complex assembly (GO:0010257)3.66743711
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66743711
31protein complex biogenesis (GO:0070271)3.65773852
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65461547
33DNA catabolic process, exonucleolytic (GO:0000738)3.62453962
34regulation of cellular amino acid metabolic process (GO:0006521)3.60911061
35regulation of RIG-I signaling pathway (GO:0039535)3.60806169
36regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.60789475
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52459161
38positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51860834
39DNA strand elongation (GO:0022616)3.48228931
40purine-containing compound salvage (GO:0043101)3.47594471
41DNA synthesis involved in DNA repair (GO:0000731)3.45464659
42mitochondrial respiratory chain complex assembly (GO:0033108)3.45209906
43spliceosomal tri-snRNP complex assembly (GO:0000244)3.44323746
44telomere maintenance via semi-conservative replication (GO:0032201)3.44234453
45amino acid salvage (GO:0043102)3.42669272
46L-methionine salvage (GO:0071267)3.42669272
47L-methionine biosynthetic process (GO:0071265)3.42669272
48cytochrome complex assembly (GO:0017004)3.42633486
49protein localization to chromosome, centromeric region (GO:0071459)3.39814624
50peptidyl-arginine N-methylation (GO:0035246)3.39548562
51peptidyl-arginine methylation (GO:0018216)3.39548562
52inositol phosphate dephosphorylation (GO:0046855)3.38323206
53phosphorylated carbohydrate dephosphorylation (GO:0046838)3.38323206
54DNA replication checkpoint (GO:0000076)3.37542813
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.34284883
56establishment of viral latency (GO:0019043)3.33499856
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33242309
58maturation of 5.8S rRNA (GO:0000460)3.32298486
59inositol phosphate catabolic process (GO:0071545)3.30269187
60purine nucleotide salvage (GO:0032261)3.29897092
61establishment of chromosome localization (GO:0051303)3.28140294
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27760106
63DNA replication initiation (GO:0006270)3.24937161
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24659412
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24659412
66negative regulation of ligase activity (GO:0051352)3.24614527
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24614527
68mitotic sister chromatid segregation (GO:0000070)3.23632450
69oxidative phosphorylation (GO:0006119)3.22945036
70formation of translation preinitiation complex (GO:0001731)3.22925393
71DNA double-strand break processing (GO:0000729)3.20984646
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19576900
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19576900
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19576900
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.19085897
76nuclear envelope organization (GO:0006998)3.17272376
77IMP biosynthetic process (GO:0006188)3.17184631
78mitotic cell cycle arrest (GO:0071850)3.17176676
79DNA ligation (GO:0006266)3.16505931
80establishment of integrated proviral latency (GO:0075713)3.16500401
81proline biosynthetic process (GO:0006561)3.15513493
82ribosome assembly (GO:0042255)3.14593920
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.10584159
84telomere maintenance via recombination (GO:0000722)3.09797239
85pyrimidine dimer repair (GO:0006290)3.09219263
86DNA duplex unwinding (GO:0032508)3.09203373
87purine ribonucleotide transport (GO:0015868)3.09084237
88base-excision repair (GO:0006284)3.07832718
89signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07448847
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.07448847
91protein K11-linked ubiquitination (GO:0070979)3.07018416
92adenosine receptor signaling pathway (GO:0001973)3.04660465
93signal transduction involved in cell cycle checkpoint (GO:0072395)3.03947740
94snRNA metabolic process (GO:0016073)3.03038267
95histone H2A acetylation (GO:0043968)3.02141190
96positive regulation of interferon-alpha production (GO:0032727)3.01015938
97mismatch repair (GO:0006298)3.00869240
98negative regulation of myeloid cell apoptotic process (GO:0033033)3.00757804
99DNA geometric change (GO:0032392)2.99053343
100protein-cofactor linkage (GO:0018065)2.98170399
101succinate metabolic process (GO:0006105)2.97988532
102purinergic nucleotide receptor signaling pathway (GO:0035590)2.97854002
103mitotic nuclear envelope disassembly (GO:0007077)2.97275987
104nucleotide transmembrane transport (GO:1901679)2.96369628
105mitochondrial fusion (GO:0008053)2.96202796
106adenine nucleotide transport (GO:0051503)2.93973477
1077-methylguanosine mRNA capping (GO:0006370)2.93181961
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.92950257
109mitotic recombination (GO:0006312)2.92470908
110RNA capping (GO:0036260)2.90088788
1117-methylguanosine RNA capping (GO:0009452)2.90088788
112deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90014320
113protein localization to chromosome (GO:0034502)2.89262097
114negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.87039993
115type B pancreatic cell proliferation (GO:0044342)2.86533638
116nuclear envelope disassembly (GO:0051081)2.86179364
117membrane disassembly (GO:0030397)2.86179364
118DNA unwinding involved in DNA replication (GO:0006268)2.85445233
119guanosine-containing compound biosynthetic process (GO:1901070)2.85432601
120CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.84849250
121mRNA cleavage (GO:0006379)2.83618489
122sister chromatid segregation (GO:0000819)2.82441406
123mitochondrial DNA metabolic process (GO:0032042)2.82118024
124nuclear pore complex assembly (GO:0051292)2.81767079
125UV protection (GO:0009650)2.81702845
126mitotic sister chromatid cohesion (GO:0007064)2.80700524
127DNA replication-dependent nucleosome assembly (GO:0006335)2.79359720
128DNA replication-dependent nucleosome organization (GO:0034723)2.79359720
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79254520
130deoxyribonucleotide biosynthetic process (GO:0009263)2.78566396
131snRNA processing (GO:0016180)2.76772675
132positive regulation of ligase activity (GO:0051351)2.76049857
133aerobic respiration (GO:0009060)2.75678045
134regulation of interferon-alpha production (GO:0032647)2.75441988
135IMP metabolic process (GO:0046040)2.72631024
136mitochondrial DNA replication (GO:0006264)2.72555609
137nucleotide-sugar biosynthetic process (GO:0009226)2.70347375
138quinone biosynthetic process (GO:1901663)2.69652881
139ubiquinone biosynthetic process (GO:0006744)2.69652881
140deoxyribose phosphate biosynthetic process (GO:0046385)2.69048904
1412-deoxyribonucleotide biosynthetic process (GO:0009265)2.69048904
142ATP synthesis coupled proton transport (GO:0015986)2.68675575
143energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68675575
144synapsis (GO:0007129)2.68300912
145metallo-sulfur cluster assembly (GO:0031163)2.68264067
146iron-sulfur cluster assembly (GO:0016226)2.68264067
147branched-chain amino acid catabolic process (GO:0009083)2.68147581
148lipid particle organization (GO:0034389)2.67976702
149regulation of acyl-CoA biosynthetic process (GO:0050812)2.67832079
150Golgi transport vesicle coating (GO:0048200)2.67545181
151COPI coating of Golgi vesicle (GO:0048205)2.67545181
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.66075279
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66075279
154negative regulation of bone mineralization (GO:0030502)2.65773106
155intra-S DNA damage checkpoint (GO:0031573)2.65704197
156tRNA aminoacylation for protein translation (GO:0006418)2.65390151
157regulation of spindle organization (GO:0090224)2.65298282
158purine nucleobase metabolic process (GO:0006144)2.64955286
159positive regulation of mitochondrial fission (GO:0090141)2.64754427
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.63641483
161termination of RNA polymerase III transcription (GO:0006386)2.63641483
162lens fiber cell differentiation (GO:0070306)2.63628712
163chaperone-mediated protein transport (GO:0072321)2.63246117
164ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.62883843
165nucleoside bisphosphate biosynthetic process (GO:0033866)2.62883843
166purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.62883843
167glycolytic process (GO:0006096)2.61617608
168amino acid activation (GO:0043038)2.61386057
169tRNA aminoacylation (GO:0043039)2.61386057
170DNA integration (GO:0015074)2.61378912
171CENP-A containing nucleosome assembly (GO:0034080)2.61145832
172nucleoside salvage (GO:0043174)2.60318592
173spindle checkpoint (GO:0031577)2.59879406
174negative regulation of DNA recombination (GO:0045910)2.59807025
175pore complex assembly (GO:0046931)2.59115586
176microtubule depolymerization (GO:0007019)2.57860201
177dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.56283020
178sialylation (GO:0097503)2.55828410
179mitotic spindle checkpoint (GO:0071174)2.55108852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13289428
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.26072662
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09717475
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.99836389
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.67583210
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60809032
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.52781973
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.50179075
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.37805386
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.32110250
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31622593
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.29024894
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00990669
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.87952932
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86642875
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.68240202
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.51159098
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46295605
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43963358
20VDR_21846776_ChIP-Seq_THP-1_Human2.42742056
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.35276112
22* VDR_23849224_ChIP-Seq_CD4+_Human2.34471155
23* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.34352754
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.30146845
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23628275
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22465260
27* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.21541996
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18242993
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16852713
30* GABP_19822575_ChIP-Seq_HepG2_Human2.06406069
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06210861
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05692129
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.03628600
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97798901
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97115536
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96415560
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.96193753
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90867928
39* DCP1A_22483619_ChIP-Seq_HELA_Human1.89214067
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86673206
41* XRN2_22483619_ChIP-Seq_HELA_Human1.85690240
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82957212
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81968243
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81853938
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81759615
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79795252
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78548829
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75405570
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.74452631
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74191106
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72947555
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70512751
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66112767
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66102483
55DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64535466
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.61920430
57MAF_26560356_Chip-Seq_TH2_Human1.60714136
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58406172
59ELK1_19687146_ChIP-ChIP_HELA_Human1.57995381
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.54800279
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54500370
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53625219
63MAF_26560356_Chip-Seq_TH1_Human1.49688610
64CIITA_25753668_ChIP-Seq_RAJI_Human1.43578313
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42772356
66ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41893041
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41054236
68* TTF2_22483619_ChIP-Seq_HELA_Human1.40199903
69P68_20966046_ChIP-Seq_HELA_Human1.39814091
70FOXP1_21924763_ChIP-Seq_HESCs_Human1.38034002
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.35296262
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34664715
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.31982443
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30301559
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28581309
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28057176
77* E2F1_21310950_ChIP-Seq_MCF-7_Human1.27611007
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27142762
79AR_21909140_ChIP-Seq_LNCAP_Human1.26210165
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20889803
81* RARB_24833708_ChIP-Seq_LIVER_Mouse1.20331941
82UTX_26944678_Chip-Seq_JUKART_Human1.19771238
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19082689
84BCOR_27268052_Chip-Seq_Bcells_Human1.18516161
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18476505
86MYC_18940864_ChIP-ChIP_HL60_Human1.16892780
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16715652
88* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16521529
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13762946
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.13027423
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11952368
92RACK7_27058665_Chip-Seq_MCF-7_Human1.06338241
93E2F1_20622854_ChIP-Seq_HELA_Human1.05311680
94PHF8_20622854_ChIP-Seq_HELA_Human1.05079345
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04080098
96PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03869667
97TET1_21451524_ChIP-Seq_MESCs_Mouse1.03707336
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.02875631
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02301727
100CTCF_21964334_Chip-Seq_Bcells_Human0.99948537
101* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99853988
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.99193731
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98862996
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98502232
105SPI1_23547873_ChIP-Seq_NB4_Human0.98493931
106ETS1_21867929_ChIP-Seq_TH2_Mouse0.98326634
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98268919
108LXR_22292898_ChIP-Seq_THP-1_Human0.96563879
109* RARA_24833708_ChIP-Seq_LIVER_Mouse0.96140477
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94486219
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94411356
112* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88570283
113TFEB_21752829_ChIP-Seq_HELA_Human0.88191986
114CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87611578
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87029092
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86766236
117KDM5A_27292631_Chip-Seq_BREAST_Human0.86737937
118YY1_22570637_ChIP-Seq_MALME-3M_Human0.86365921
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86362369
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86159549
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85692777
122RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84716243
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84496324
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81203726
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81158014
126BCL6_27268052_Chip-Seq_Bcells_Human0.79969349
127MYC_22102868_ChIP-Seq_BL_Human0.79099845
128IRF1_19129219_ChIP-ChIP_H3396_Human0.77227066
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73918300
130ERG_20517297_ChIP-Seq_VCAP_Human0.73274861
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.73068548
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69680785
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.68788351
134PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68541124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation4.15752656
2MP0005423_abnormal_somatic_nervous3.37184732
3MP0000751_myopathy3.30411433
4MP0000372_irregular_coat_pigmentation3.04689754
5MP0005083_abnormal_biliary_tract2.93775158
6MP0001986_abnormal_taste_sensitivity2.81905859
7MP0003123_paternal_imprinting2.81031673
8MP0005174_abnormal_tail_pigmentation2.80434306
9MP0003136_yellow_coat_color2.66768392
10MP0005075_abnormal_melanosome_morpholog2.64704264
11MP0003879_abnormal_hair_cell2.64443063
12MP0002876_abnormal_thyroid_physiology2.54835468
13MP0008057_abnormal_DNA_replication2.42185451
14MP0004147_increased_porphyrin_level2.39307468
15MP0009333_abnormal_splenocyte_physiolog2.28724487
16MP0001348_abnormal_lacrimal_gland2.24488774
17MP0008877_abnormal_DNA_methylation2.22411511
18MP0006036_abnormal_mitochondrial_physio2.20460610
19MP0005408_hypopigmentation2.14773438
20MP0010094_abnormal_chromosome_stability2.14036386
21MP0003693_abnormal_embryo_hatching2.13101884
22MP0008058_abnormal_DNA_repair2.11587616
23MP0005671_abnormal_response_to2.10487050
24MP0001346_abnormal_lacrimal_gland2.03210163
25MP0005085_abnormal_gallbladder_physiolo2.00760258
26MP0005365_abnormal_bile_salt2.00611184
27MP0004957_abnormal_blastocyst_morpholog1.98647087
28MP0003646_muscle_fatigue1.97970380
29MP0001764_abnormal_homeostasis1.95046964
30MP0003806_abnormal_nucleotide_metabolis1.89587503
31MP0003186_abnormal_redox_activity1.89476177
32MP0001661_extended_life_span1.86303101
33MP0006035_abnormal_mitochondrial_morpho1.81688342
34MP0002736_abnormal_nociception_after1.81456823
35MP0002139_abnormal_hepatobiliary_system1.80200190
36MP0008007_abnormal_cellular_replicative1.77858929
37MP0005397_hematopoietic_system_phenotyp1.75529084
38MP0001545_abnormal_hematopoietic_system1.75529084
39MP0002396_abnormal_hematopoietic_system1.72521082
40MP0008260_abnormal_autophagy1.69047493
41MP0002822_catalepsy1.66797868
42MP0000750_abnormal_muscle_regeneration1.64636650
43MP0008875_abnormal_xenobiotic_pharmacok1.63888214
44MP0000747_muscle_weakness1.63634520
45MP0003077_abnormal_cell_cycle1.63195410
46MP0003221_abnormal_cardiomyocyte_apopto1.60786072
47MP0003787_abnormal_imprinting1.57206080
48MP0003011_delayed_dark_adaptation1.56133743
49MP0005501_abnormal_skin_physiology1.54733976
50MP0005360_urolithiasis1.51338630
51MP0003718_maternal_effect1.47951643
52MP0004142_abnormal_muscle_tone1.47163743
53MP0003453_abnormal_keratinocyte_physiol1.46809203
54MP0002160_abnormal_reproductive_system1.46248216
55MP0005623_abnormal_meninges_morphology1.45182618
56MP0009046_muscle_twitch1.43185725
57MP0000013_abnormal_adipose_tissue1.42882853
58MP0001968_abnormal_touch/_nociception1.42286470
59MP0001529_abnormal_vocalization1.40290270
60MP0003656_abnormal_erythrocyte_physiolo1.39575299
61MP0009785_altered_susceptibility_to1.37240942
62MP0004197_abnormal_fetal_growth/weight/1.32083233
63MP0004782_abnormal_surfactant_physiolog1.32061045
64MP0000015_abnormal_ear_pigmentation1.32043938
65MP0009840_abnormal_foam_cell1.31208731
66MP0002080_prenatal_lethality1.28942652
67MP0002132_abnormal_respiratory_system1.28381266
68MP0005451_abnormal_body_composition1.27994644
69MP0005330_cardiomyopathy1.27930240
70MP0001835_abnormal_antigen_presentation1.27679048
71MP0003122_maternal_imprinting1.26502791
72MP0010329_abnormal_lipoprotein_level1.26436329
73MP0000689_abnormal_spleen_morphology1.26192562
74MP0003763_abnormal_thymus_physiology1.25383262
75MP0000681_abnormal_thyroid_gland1.24959433
76MP0000490_abnormal_crypts_of1.23488781
77MP0003111_abnormal_nucleus_morphology1.19558649
78MP0000313_abnormal_cell_death1.19063973
79MP0000350_abnormal_cell_proliferation1.18243999
80MP0003183_abnormal_peptide_metabolism1.17432321
81MP0006292_abnormal_olfactory_placode1.16750529
82MP0001905_abnormal_dopamine_level1.15180744
83MP0002398_abnormal_bone_marrow1.12110768
84MP0001672_abnormal_embryogenesis/_devel1.10128672
85MP0005380_embryogenesis_phenotype1.10128672
86MP0005584_abnormal_enzyme/coenzyme_acti1.09892179
87MP0003121_genomic_imprinting1.09742471
88MP0006054_spinal_hemorrhage1.09118692
89MP0005646_abnormal_pituitary_gland1.08299738
90MP0005636_abnormal_mineral_homeostasis1.07214500
91MP0004233_abnormal_muscle_weight1.07046680
92MP0002722_abnormal_immune_system1.05701586
93MP0005389_reproductive_system_phenotype1.05568408
94MP0003786_premature_aging1.03367158
95MP0008995_early_reproductive_senescence1.03142668
96MP0000749_muscle_degeneration1.00930949
97MP0001697_abnormal_embryo_size1.00607194
98MP0005332_abnormal_amino_acid1.00352991
99MP0003880_abnormal_central_pattern0.99446662
100MP0001243_abnormal_dermal_layer0.98769114
101MP0003984_embryonic_growth_retardation0.98387812
102MP0001188_hyperpigmentation0.98190090
103MP0002638_abnormal_pupillary_reflex0.97587832
104MP0001502_abnormal_circadian_rhythm0.96856884
105MP0005384_cellular_phenotype0.96240664
106MP0008789_abnormal_olfactory_epithelium0.96177515
107MP0005319_abnormal_enzyme/_coenzyme0.96084588
108MP0005621_abnormal_cell_physiology0.94066878
109MP0005266_abnormal_metabolism0.94058806
110MP0002088_abnormal_embryonic_growth/wei0.92654989
111MP0008932_abnormal_embryonic_tissue0.91186085
112MP0002075_abnormal_coat/hair_pigmentati0.90312057
113MP0004381_abnormal_hair_follicle0.89322532
114MP0002095_abnormal_skin_pigmentation0.88626371
115MP0000371_diluted_coat_color0.88412608
116MP0000685_abnormal_immune_system0.88193238
117MP0005076_abnormal_cell_differentiation0.87801116
118MP0002210_abnormal_sex_determination0.87216726
119MP0008872_abnormal_physiological_respon0.86870248
120MP0005367_renal/urinary_system_phenotyp0.86821341
121MP0000516_abnormal_urinary_system0.86821341
122MP0001730_embryonic_growth_arrest0.85198953
123MP0005025_abnormal_response_to0.84242734
124MP0000358_abnormal_cell_content/0.84034792
125MP0002653_abnormal_ependyma_morphology0.83381708
126MP0002429_abnormal_blood_cell0.82153385
127MP0000716_abnormal_immune_system0.78543057
128MP0003635_abnormal_synaptic_transmissio0.77761532
129MP0001191_abnormal_skin_condition0.76747552
130MP0002085_abnormal_embryonic_tissue0.76704056
131MP0003943_abnormal_hepatobiliary_system0.76680378
132MP0001919_abnormal_reproductive_system0.75579734
133MP0005376_homeostasis/metabolism_phenot0.73865494
134MP0001819_abnormal_immune_cell0.73507611
135MP0008469_abnormal_protein_level0.72962692
136MP0001756_abnormal_urination0.72380130
137MP0001929_abnormal_gametogenesis0.72061803
138MP0002420_abnormal_adaptive_immunity0.71516015
139MP0010771_integument_phenotype0.71426401
140MP0001145_abnormal_male_reproductive0.71175178
141MP0000598_abnormal_liver_morphology0.71075196
142MP0002419_abnormal_innate_immunity0.70609896
143MP0002166_altered_tumor_susceptibility0.70415501
144MP0005410_abnormal_fertilization0.70320167
145MP0003448_altered_tumor_morphology0.70072890
146MP0004215_abnormal_myocardial_fiber0.70069064
147MP0000703_abnormal_thymus_morphology0.69882547
148MP0002086_abnormal_extraembryonic_tissu0.69587986
149MP0003698_abnormal_male_reproductive0.69461783
150MP0005171_absent_coat_pigmentation0.69383899
151MP0009278_abnormal_bone_marrow0.69112386
152MP0002019_abnormal_tumor_incidence0.68851503
153MP0005394_taste/olfaction_phenotype0.68371726
154MP0005499_abnormal_olfactory_system0.68371726
155MP0004808_abnormal_hematopoietic_stem0.68096580
156MP0001984_abnormal_olfaction0.67323103
157MP0000465_gastrointestinal_hemorrhage0.67081046
158MP0004270_analgesia0.65658254
159MP0005058_abnormal_lysosome_morphology0.65147529
160MP0000759_abnormal_skeletal_muscle0.65056045
161MP0002277_abnormal_respiratory_mucosa0.64304735
162MP0000003_abnormal_adipose_tissue0.61310003
163MP0008873_increased_physiological_sensi0.60095988
164MP0009931_abnormal_skin_appearance0.59517280
165MP0001293_anophthalmia0.58678482
166MP0000653_abnormal_sex_gland0.58084997
167MP0005409_darkened_coat_color0.56156757
168MP0004264_abnormal_extraembryonic_tissu0.55854520
169MP0001216_abnormal_epidermal_layer0.55546471
170MP0002735_abnormal_chemical_nociception0.55054920

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)5.50491498
2Poikiloderma (HP:0001029)5.49121017
3Dyschromatopsia (HP:0007641)4.91408540
4Hepatocellular necrosis (HP:0001404)4.87317673
5Hepatic necrosis (HP:0002605)4.46964127
6Facial hemangioma (HP:0000329)4.45458350
7Selective tooth agenesis (HP:0001592)4.32527707
8Squamous cell carcinoma (HP:0002860)4.27065145
9Increased CSF lactate (HP:0002490)4.12950036
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.05673360
11Abnormality of glycolysis (HP:0004366)4.04260578
12Increased serum pyruvate (HP:0003542)4.04260578
13Abnormal mitochondria in muscle tissue (HP:0008316)3.86634397
14Mitochondrial inheritance (HP:0001427)3.76127879
15Increased serum lactate (HP:0002151)3.73487779
16Basal cell carcinoma (HP:0002671)3.67981928
173-Methylglutaconic aciduria (HP:0003535)3.65290181
18Ragged-red muscle fibers (HP:0003200)3.60636089
19Reduced antithrombin III activity (HP:0001976)3.53671175
20Popliteal pterygium (HP:0009756)3.46779331
21Rectovaginal fistula (HP:0000143)3.45133327
22Rectal fistula (HP:0100590)3.45133327
23Attenuation of retinal blood vessels (HP:0007843)3.42779016
24Acute necrotizing encephalopathy (HP:0006965)3.41612491
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40744454
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40744454
27Akinesia (HP:0002304)3.39036474
28Hypothermia (HP:0002045)3.38614754
29Progressive macrocephaly (HP:0004481)3.32407039
30Abnormality of alanine metabolism (HP:0010916)3.30306554
31Hyperalaninemia (HP:0003348)3.30306554
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.30306554
33Abnormality of the heme biosynthetic pathway (HP:0010472)3.29297793
34Lactic acidosis (HP:0003128)3.28156289
35Rib fusion (HP:0000902)3.26596462
36Vaginal fistula (HP:0004320)3.26579581
37Type I transferrin isoform profile (HP:0003642)3.25158033
38Ulnar bowing (HP:0003031)3.23776432
39Amniotic constriction ring (HP:0009775)3.19131395
40Abnormality of placental membranes (HP:0011409)3.19131395
41Neonatal respiratory distress (HP:0002643)3.16378753
42Facial diplegia (HP:0001349)3.15751918
43Anteriorly placed anus (HP:0001545)3.15674114
44Acute encephalopathy (HP:0006846)3.14375559
45Fetal akinesia sequence (HP:0001989)3.05519223
46Intestinal fistula (HP:0100819)3.04088098
47Cholelithiasis (HP:0001081)2.98205388
48Microvesicular hepatic steatosis (HP:0001414)2.94090703
49Increased intramyocellular lipid droplets (HP:0012240)2.93336621
50Cutaneous melanoma (HP:0012056)2.92439431
51Progressive external ophthalmoplegia (HP:0000590)2.89728080
52Aplastic anemia (HP:0001915)2.86231917
53Choroideremia (HP:0001139)2.77061952
54Neoplasm of the adrenal gland (HP:0100631)2.75314854
55Poor suck (HP:0002033)2.75133276
56Abnormality of the intrinsic pathway (HP:0010989)2.73461397
57Aplasia of the musculature (HP:0100854)2.73088649
58Entropion (HP:0000621)2.69313712
59Increased muscle lipid content (HP:0009058)2.67083853
60Thin bony cortex (HP:0002753)2.65123253
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64967028
62Long clavicles (HP:0000890)2.63857004
63Thyroid-stimulating hormone excess (HP:0002925)2.60450817
64Increased hepatocellular lipid droplets (HP:0006565)2.59244389
65Abnormal gallbladder morphology (HP:0012437)2.59178722
66Exercise intolerance (HP:0003546)2.57812666
67Shoulder girdle muscle weakness (HP:0003547)2.56222689
68Lipid accumulation in hepatocytes (HP:0006561)2.55391680
69Cerebral edema (HP:0002181)2.54114895
70Conjunctival hamartoma (HP:0100780)2.53497119
71Patellar aplasia (HP:0006443)2.50828587
72Capillary hemangiomas (HP:0005306)2.44742925
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40834025
74Abnormal number of erythroid precursors (HP:0012131)2.39411725
75Annular pancreas (HP:0001734)2.39218028
76CNS demyelination (HP:0007305)2.38676644
77Respiratory failure (HP:0002878)2.37419158
78Respiratory difficulties (HP:0002880)2.35051174
79Poor head control (HP:0002421)2.35000612
80Epiphyseal stippling (HP:0010655)2.34840445
81Premature graying of hair (HP:0002216)2.30909341
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.28342221
83Abnormal protein N-linked glycosylation (HP:0012347)2.28342221
84Abnormal protein glycosylation (HP:0012346)2.28342221
85Abnormal glycosylation (HP:0012345)2.28342221
86Elevated erythrocyte sedimentation rate (HP:0003565)2.28247039
87Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28146577
88Hypoplastic pelvis (HP:0008839)2.27814999
89Hemorrhage of the eye (HP:0011885)2.27131726
90Myotonia (HP:0002486)2.27063531
91Opisthotonus (HP:0002179)2.26358603
92Emotional lability (HP:0000712)2.25965867
93Thrombocytosis (HP:0001894)2.25709009
94Type 2 muscle fiber atrophy (HP:0003554)2.24340693
95IgM deficiency (HP:0002850)2.24003388
96Aplasia/Hypoplasia involving the musculature (HP:0001460)2.22031516
97Myopathic facies (HP:0002058)2.21423426
98Unsteady gait (HP:0002317)2.21016320
99Aplasia/Hypoplasia of the patella (HP:0006498)2.18444978
100Mesangial abnormality (HP:0001966)2.15311271
101Pulmonary fibrosis (HP:0002206)2.14952705
102Tubulointerstitial nephritis (HP:0001970)2.14295739
103Diminished movement (HP:0002374)2.14106197
104Metabolic acidosis (HP:0001942)2.13954170
105Neuroendocrine neoplasm (HP:0100634)2.12254444
106Abnormal epiphyseal ossification (HP:0010656)2.11008213
107Turricephaly (HP:0000262)2.10991618
108Bony spicule pigmentary retinopathy (HP:0007737)2.10885571
109Postnatal microcephaly (HP:0005484)2.10872024
110Oral leukoplakia (HP:0002745)2.08788267
111Lethargy (HP:0001254)2.07571158
112Gliosis (HP:0002171)2.07139895
113Absent radius (HP:0003974)2.06059671
114Abnormality of cells of the erythroid lineage (HP:0012130)2.05602370
115Abnormal spermatogenesis (HP:0008669)2.05263846
116Abnormality of pyrimidine metabolism (HP:0004353)2.04058651
117Abnormalities of placenta or umbilical cord (HP:0001194)2.03252893
118Medulloblastoma (HP:0002885)2.01214654
119Hyperbilirubinemia (HP:0002904)1.98717670
120Malignant hyperthermia (HP:0002047)1.98025323
121Absent forearm bone (HP:0003953)1.97488308
122Aplasia involving forearm bones (HP:0009822)1.97488308
123Dicarboxylic aciduria (HP:0003215)1.96912872
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96912872
125Ependymoma (HP:0002888)1.95649561
126Cortical visual impairment (HP:0100704)1.95496641
127Exertional dyspnea (HP:0002875)1.92499958
128Pheochromocytoma (HP:0002666)1.91794165
129Muscle fiber atrophy (HP:0100295)1.91745781
130Hyperammonemia (HP:0001987)1.91165080
131Abnormality of serum amino acid levels (HP:0003112)1.90989410
132Prolonged partial thromboplastin time (HP:0003645)1.89942192
133Progressive muscle weakness (HP:0003323)1.89817630
134Birth length less than 3rd percentile (HP:0003561)1.89078307
135Hypoplasia of the thymus (HP:0000778)1.88870810
136Abnormal gallbladder physiology (HP:0012438)1.88231398
137Cholecystitis (HP:0001082)1.88231398
138Hypobetalipoproteinemia (HP:0003563)1.88004125
139Joint hemorrhage (HP:0005261)1.87959086
140Rimmed vacuoles (HP:0003805)1.86891352
141Progressive microcephaly (HP:0000253)1.86364532
142Horizontal nystagmus (HP:0000666)1.85451021
143Neoplasm of head and neck (HP:0012288)1.85357782
144Esophageal neoplasm (HP:0100751)1.85357782
145Chromsome breakage (HP:0040012)1.84955914
146Pelvic girdle muscle weakness (HP:0003749)1.84563483
147Renal Fanconi syndrome (HP:0001994)1.84492082
148Rhabdomyolysis (HP:0003201)1.84443129
149Abnormal trabecular bone morphology (HP:0100671)1.84261750
150Atrioventricular block (HP:0001678)1.84163679
151Hyperglycinemia (HP:0002154)1.83172876
152Myelodysplasia (HP:0002863)1.82924446
153Cortical dysplasia (HP:0002539)1.82840680
154Abnormality of the basal ganglia (HP:0002134)1.82279974
155Thin ribs (HP:0000883)1.81642873
156Optic nerve coloboma (HP:0000588)1.81397183
157Agnosia (HP:0010524)1.80865613
15811 pairs of ribs (HP:0000878)1.78989288
159Exercise-induced muscle cramps (HP:0003710)1.78896685
160Mediastinal lymphadenopathy (HP:0100721)1.78262515
161Thyroiditis (HP:0100646)1.77980578
162Failure to thrive in infancy (HP:0001531)1.77748383
163Pancytopenia (HP:0001876)1.77105133
164B lymphocytopenia (HP:0010976)1.76929568
165Abnormality of B cell number (HP:0010975)1.76929568
166Vertebral compression fractures (HP:0002953)1.75785013
167Delayed epiphyseal ossification (HP:0002663)1.74868539
168Abnormal hair whorl (HP:0010721)1.74514962
169Abnormality of fatty-acid metabolism (HP:0004359)1.72769915
170Cystic hygroma (HP:0000476)1.70480221
171Optic disc pallor (HP:0000543)1.69408087
172Abnormality of monocarboxylic acid metabolism (HP:0010996)1.66348553
173Muscular hypotonia of the trunk (HP:0008936)1.66250785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.53300120
2TRIM283.70659797
3TESK23.35861576
4STK163.23848347
5CCNB13.22478804
6FRK3.00729534
7TTK2.91206924
8PRPF4B2.90120791
9TNIK2.89958778
10CDK192.89315250
11WEE12.83911178
12EIF2AK12.78632286
13MAP3K122.75831165
14BCKDK2.59867942
15TSSK62.29283683
16PBK2.29083571
17BUB12.26162786
18BRSK22.15314353
19CASK2.13295229
20MAP2K72.04005423
21CDC71.92335160
22PDK41.92028875
23PDK31.92028875
24SRPK11.88631589
25VRK11.78768447
26DAPK11.78457978
27BCR1.77433141
28EIF2AK31.74264907
29FES1.67930297
30BRSK11.64512575
31NEK11.63798699
32TAOK21.61455574
33SCYL21.44679741
34SIK31.42580807
35NUAK11.36337104
36FLT31.35930845
37STK101.33871565
38CDK61.33003397
39KIT1.28678478
40CAMKK21.25173988
41TLK11.24965303
42PLK31.23076319
43ACVR1B1.20494996
44EPHB11.17290522
45MUSK1.16723266
46DYRK1B1.16577709
47YES11.16010131
48BLK1.12012846
49TESK11.10509488
50NME21.07620400
51NEK91.07480572
52EPHA21.05032781
53CDK81.01295138
54IRAK21.00422052
55MST40.98416753
56TGFBR10.98107743
57PIM20.97978177
58TEC0.97701379
59AURKA0.93101644
60MAP2K60.92607052
61CDK140.89475660
62SYK0.88755319
63NTRK30.86468193
64MAP2K40.85961528
65EPHA30.85059739
66MAP2K30.83674392
67GRK60.83541633
68PAK40.83276116
69PLK10.81360793
70MAP4K10.80833251
71ATR0.80409053
72MAP4K20.80320067
73AURKB0.78989280
74CLK10.77068911
75NEK60.76223763
76MAP3K40.75213044
77ERBB30.74379529
78MAP3K110.71842152
79ABL20.70195129
80TXK0.70070543
81PAK60.69421163
82ZAK0.68888309
83CSNK1G10.68678198
84VRK20.67987351
85CSNK1G30.67653490
86KDR0.66601516
87FGFR20.66226635
88ADRBK20.65486474
89MAPK40.64441798
90MAPK130.64378540
91BTK0.63774133
92MKNK10.62896489
93PRKD30.59836518
94PLK40.59751515
95NME10.58650890
96LYN0.56576442
97SIK20.56122398
98MYLK0.55518752
99CHEK10.54535736
100RPS6KA50.54208160
101CSNK1A1L0.53859719
102PAK10.52585449
103BMPR1B0.51845685
104DYRK30.51162579
105ZAP700.49249477
106CHEK20.48643400
107RAF10.46988700
108CSNK2A10.46973315
109EIF2AK20.46737473
110AKT20.45797252
111PLK20.44093730
112MELK0.43445170
113SMG10.43004273
114ERN10.43001680
115PINK10.42669924
116CSF1R0.41849357
117BMX0.41652258
118BRD40.41451552
119PRKD10.41389473
120PRKCG0.41292657
121ERBB40.40777068
122CDK70.40457429
123TAOK30.39891647
124TRIB30.39795555
125CSNK1G20.39776375
126LMTK20.39366050
127CDK40.39259284
128UHMK10.39040891
129CSNK2A20.38412430
130PASK0.38379982
131LATS10.38348240
132WNK30.38102873
133PIM10.37277954
134TBK10.36880446
135ATM0.36844580
136IKBKE0.36220559
137CDK10.35761911
138PRKCI0.35385321
139LIMK10.34999164
140CDK20.34516084
141MKNK20.32869989
142CDK180.32401315
143IRAK40.31998990
144BRAF0.30672120
145MAPK110.29478597
146PDK20.28109550
147RPS6KB10.27686067
148DAPK20.27330595
149ADRBK10.25972671
150TYK20.25533780
151CDK150.23405097
152CDK11A0.22745516
153PRKCD0.22001161

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.01221175
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.71379971
3DNA replication_Homo sapiens_hsa030303.64790230
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.92529232
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.90855262
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.67235920
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50505043
8RNA polymerase_Homo sapiens_hsa030202.36661903
9Base excision repair_Homo sapiens_hsa034102.29122930
10Pyrimidine metabolism_Homo sapiens_hsa002402.23845224
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20150593
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16768990
13Mismatch repair_Homo sapiens_hsa034302.16671875
14Oxidative phosphorylation_Homo sapiens_hsa001902.07617300
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.07078424
16Ribosome_Homo sapiens_hsa030102.06612634
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94578778
18Parkinsons disease_Homo sapiens_hsa050121.93143054
19Nucleotide excision repair_Homo sapiens_hsa034201.92364830
20Pyruvate metabolism_Homo sapiens_hsa006201.90288417
21Spliceosome_Homo sapiens_hsa030401.87259335
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.87257288
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83479844
24Homologous recombination_Homo sapiens_hsa034401.81215071
25Carbon metabolism_Homo sapiens_hsa012001.81043672
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73398037
27Biosynthesis of amino acids_Homo sapiens_hsa012301.71027058
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57978859
29One carbon pool by folate_Homo sapiens_hsa006701.54400898
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53199361
31Propanoate metabolism_Homo sapiens_hsa006401.46428534
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.41382279
33Purine metabolism_Homo sapiens_hsa002301.39558757
34Vitamin B6 metabolism_Homo sapiens_hsa007501.37891111
35Huntingtons disease_Homo sapiens_hsa050161.37008499
36Protein export_Homo sapiens_hsa030601.34526180
37Basal transcription factors_Homo sapiens_hsa030221.32879767
38Steroid biosynthesis_Homo sapiens_hsa001001.30612052
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29540211
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.29259860
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24444145
42Circadian rhythm_Homo sapiens_hsa047101.21949952
43RNA degradation_Homo sapiens_hsa030181.21601973
44Selenocompound metabolism_Homo sapiens_hsa004501.18368442
45Nicotine addiction_Homo sapiens_hsa050331.16515171
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15875509
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.14995999
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14986773
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14246852
50RNA transport_Homo sapiens_hsa030131.11791737
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10262152
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.09404978
53Pentose phosphate pathway_Homo sapiens_hsa000301.05562897
54Alzheimers disease_Homo sapiens_hsa050101.03950909
55Fatty acid elongation_Homo sapiens_hsa000621.01141965
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00433283
57Cell cycle_Homo sapiens_hsa041100.98595013
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94999131
59Sphingolipid metabolism_Homo sapiens_hsa006000.94699165
60Non-homologous end-joining_Homo sapiens_hsa034500.92352318
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.90915339
62Synaptic vesicle cycle_Homo sapiens_hsa047210.90208713
63Peroxisome_Homo sapiens_hsa041460.88754480
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86116468
65Inositol phosphate metabolism_Homo sapiens_hsa005620.84286126
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84020864
67Fanconi anemia pathway_Homo sapiens_hsa034600.82494991
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81056619
69N-Glycan biosynthesis_Homo sapiens_hsa005100.80134766
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79436622
71Metabolic pathways_Homo sapiens_hsa011000.79392321
72Fatty acid degradation_Homo sapiens_hsa000710.77947717
73Viral carcinogenesis_Homo sapiens_hsa052030.76651060
74Hedgehog signaling pathway_Homo sapiens_hsa043400.75042576
75Primary immunodeficiency_Homo sapiens_hsa053400.75039583
76Oocyte meiosis_Homo sapiens_hsa041140.74829916
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.74355466
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73634393
79Herpes simplex infection_Homo sapiens_hsa051680.72163192
80Colorectal cancer_Homo sapiens_hsa052100.71156169
81Collecting duct acid secretion_Homo sapiens_hsa049660.70594616
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70491178
83Alcoholism_Homo sapiens_hsa050340.70484135
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68286748
85Epstein-Barr virus infection_Homo sapiens_hsa051690.66592311
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66341741
87Endometrial cancer_Homo sapiens_hsa052130.64399213
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64129517
89Folate biosynthesis_Homo sapiens_hsa007900.64055689
90Caffeine metabolism_Homo sapiens_hsa002320.63011844
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62935673
92Butanoate metabolism_Homo sapiens_hsa006500.61844305
93Endocytosis_Homo sapiens_hsa041440.60321214
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59232379
95Apoptosis_Homo sapiens_hsa042100.54959912
96Vibrio cholerae infection_Homo sapiens_hsa051100.54765612
97Fructose and mannose metabolism_Homo sapiens_hsa000510.54388750
98mTOR signaling pathway_Homo sapiens_hsa041500.54288097
99Lysine degradation_Homo sapiens_hsa003100.53648622
100Hepatitis B_Homo sapiens_hsa051610.52706112
101Regulation of autophagy_Homo sapiens_hsa041400.51386706
102Sulfur relay system_Homo sapiens_hsa041220.51252255
103Shigellosis_Homo sapiens_hsa051310.49500684
104beta-Alanine metabolism_Homo sapiens_hsa004100.48592442
105Galactose metabolism_Homo sapiens_hsa000520.44311703
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.44263909
107Phenylalanine metabolism_Homo sapiens_hsa003600.41973092
108Arginine biosynthesis_Homo sapiens_hsa002200.40942713
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37608639
110HTLV-I infection_Homo sapiens_hsa051660.35280985
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35278435
112Tryptophan metabolism_Homo sapiens_hsa003800.34945489
113Acute myeloid leukemia_Homo sapiens_hsa052210.34145747
114p53 signaling pathway_Homo sapiens_hsa041150.33850204
115AMPK signaling pathway_Homo sapiens_hsa041520.33799701
116Lysosome_Homo sapiens_hsa041420.33282671
117Hippo signaling pathway_Homo sapiens_hsa043900.32801705
118Hepatitis C_Homo sapiens_hsa051600.32331885
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31815269
120Other glycan degradation_Homo sapiens_hsa005110.31241219
121Fatty acid metabolism_Homo sapiens_hsa012120.30863636
122Legionellosis_Homo sapiens_hsa051340.29895682
123Pancreatic cancer_Homo sapiens_hsa052120.29434379
124Taste transduction_Homo sapiens_hsa047420.28819815
125Phototransduction_Homo sapiens_hsa047440.28225307
126Glutathione metabolism_Homo sapiens_hsa004800.25828743
127Systemic lupus erythematosus_Homo sapiens_hsa053220.24365035
128Non-small cell lung cancer_Homo sapiens_hsa052230.24261727
129Chronic myeloid leukemia_Homo sapiens_hsa052200.24212166
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24186263
131Measles_Homo sapiens_hsa051620.23706928
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22304377
133Basal cell carcinoma_Homo sapiens_hsa052170.22088379
134Antigen processing and presentation_Homo sapiens_hsa046120.19798902
135Tyrosine metabolism_Homo sapiens_hsa003500.19482109
136Cardiac muscle contraction_Homo sapiens_hsa042600.18323561
137Retinol metabolism_Homo sapiens_hsa008300.16169968
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.16074699
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12874593
140Phagosome_Homo sapiens_hsa041450.11008740
141Fat digestion and absorption_Homo sapiens_hsa049750.10757974
142mRNA surveillance pathway_Homo sapiens_hsa030150.10249232

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