KCMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.98684982
2mitotic metaphase plate congression (GO:0007080)4.48006992
3production of molecular mediator involved in inflammatory response (GO:0002532)4.23153176
4intestinal epithelial cell development (GO:0060576)4.22169511
5mitotic sister chromatid cohesion (GO:0007064)4.12374423
6desmosome organization (GO:0002934)3.94465523
7histone H2A monoubiquitination (GO:0035518)3.86729375
8cellular protein complex localization (GO:0034629)3.77607198
9interferon-gamma secretion (GO:0072643)3.72635974
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71694436
11synaptonemal complex assembly (GO:0007130)3.70884769
12cell-substrate adherens junction assembly (GO:0007045)3.66652567
13focal adhesion assembly (GO:0048041)3.66652567
14positive regulation of mitotic sister chromatid separation (GO:1901970)3.65624255
15positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.65624255
16positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.65624255
17mitotic chromosome condensation (GO:0007076)3.63248286
18synaptonemal complex organization (GO:0070193)3.53482044
19positive regulation of chromosome segregation (GO:0051984)3.49552063
20regulation of sister chromatid cohesion (GO:0007063)3.47157787
21protein K6-linked ubiquitination (GO:0085020)3.45832417
22skeletal muscle contraction (GO:0003009)3.43474705
23histone H2A ubiquitination (GO:0033522)3.43467245
24sarcoplasmic reticulum calcium ion transport (GO:0070296)3.43317117
25metaphase plate congression (GO:0051310)3.42879652
26embryonic process involved in female pregnancy (GO:0060136)3.40580600
27muscle filament sliding (GO:0030049)3.39617187
28actin-myosin filament sliding (GO:0033275)3.39617187
29mRNA transcription (GO:0009299)3.38143574
30gene silencing by RNA (GO:0031047)3.38027610
31hypotonic response (GO:0006971)3.36203307
32regulation of spindle organization (GO:0090224)3.35610873
33carnitine shuttle (GO:0006853)3.34563791
34protein complex localization (GO:0031503)3.34428558
35monoubiquitinated protein deubiquitination (GO:0035520)3.30755500
36adherens junction assembly (GO:0034333)3.28795507
37sarcomere organization (GO:0045214)3.28645600
38plasma membrane repair (GO:0001778)3.24771847
39histone H3-K36 demethylation (GO:0070544)3.24137262
40nuclear pore complex assembly (GO:0051292)3.18406306
41protein localization to chromosome, centromeric region (GO:0071459)3.16972741
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.16252193
43paraxial mesoderm development (GO:0048339)3.15975449
44positive regulation of macroautophagy (GO:0016239)3.15022319
45fatty acid transmembrane transport (GO:1902001)3.14699970
46regulation of RNA export from nucleus (GO:0046831)3.14496781
47skeletal muscle fiber development (GO:0048741)3.14130320
48regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13726496
49regulation of cardioblast differentiation (GO:0051890)3.10102348
50cell-substrate junction assembly (GO:0007044)3.09036712
51response to muscle activity (GO:0014850)3.07833462
52male meiosis (GO:0007140)3.06693927
53cytoplasmic mRNA processing body assembly (GO:0033962)3.06333194
54negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.05939898
55nuclear pore organization (GO:0006999)3.03301532
56regulation of skeletal muscle contraction (GO:0014819)3.03110922
57mitotic nuclear envelope disassembly (GO:0007077)3.02732840
58negative regulation of fatty acid biosynthetic process (GO:0045717)3.00618536
59SMAD protein complex assembly (GO:0007183)2.96487638
60regulation of tight junction assembly (GO:2000810)2.96415811
61negative regulation of necroptotic process (GO:0060546)2.95741304
62actin-mediated cell contraction (GO:0070252)2.94312274
63nuclear envelope disassembly (GO:0051081)2.94280013
64membrane disassembly (GO:0030397)2.94280013
65stress fiber assembly (GO:0043149)2.92457290
66heterochromatin organization (GO:0070828)2.92041188
67cardiac muscle cell development (GO:0055013)2.91478381
68regulation of meiosis I (GO:0060631)2.90094543
69regulation of hippo signaling (GO:0035330)2.89081245
70NLS-bearing protein import into nucleus (GO:0006607)2.88435771
71negative regulation of smooth muscle cell differentiation (GO:0051151)2.88226239
72notochord development (GO:0030903)2.86555698
73labyrinthine layer development (GO:0060711)2.84690778
74carnitine transmembrane transport (GO:1902603)2.83222975
75regulation of mitotic spindle organization (GO:0060236)2.82986633
76regulation of histone H3-K9 methylation (GO:0051570)2.82235856
77establishment of chromosome localization (GO:0051303)2.79964009
78epithelial cell-cell adhesion (GO:0090136)2.78697898
79nuclear envelope organization (GO:0006998)2.77581852
80negative regulation of skeletal muscle tissue development (GO:0048642)2.77442201
81positive regulation of p38MAPK cascade (GO:1900745)2.77041726
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.74937008
83RNA stabilization (GO:0043489)2.74230498
84mRNA stabilization (GO:0048255)2.74230498
85regulation of sequestering of triglyceride (GO:0010889)2.74229986
86amino-acid betaine transport (GO:0015838)2.73717802
87carnitine transport (GO:0015879)2.73717802
88cardiac cell development (GO:0055006)2.72918555
89sister chromatid cohesion (GO:0007062)2.70841974
90hippo signaling (GO:0035329)2.70612392
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69727684
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.69727684
93regulation of translation, ncRNA-mediated (GO:0045974)2.69727684
94regulation of transforming growth factor beta2 production (GO:0032909)2.69557938
95peptidyl-threonine modification (GO:0018210)2.69538512
96positive regulation of SMAD protein import into nucleus (GO:0060391)2.68882186
97protein localization to chromosome (GO:0034502)2.68764056
98regulation of translational termination (GO:0006449)2.68529706
99protein localization to endosome (GO:0036010)2.68260809
100regulation of gene silencing by RNA (GO:0060966)2.68118536
101regulation of posttranscriptional gene silencing (GO:0060147)2.68118536
102regulation of gene silencing by miRNA (GO:0060964)2.68118536
103DNA methylation involved in gamete generation (GO:0043046)2.67748665
104skeletal muscle adaptation (GO:0043501)2.67620889
105regulation of vitamin D biosynthetic process (GO:0060556)2.67119070
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.66098742
107trophectodermal cell differentiation (GO:0001829)2.64998982
108ribosome assembly (GO:0042255)2.64705308
109peptidyl-threonine phosphorylation (GO:0018107)2.63387268
110cellular response to arsenic-containing substance (GO:0071243)2.62118218
111negative regulation of DNA repair (GO:0045738)2.61269370
112meiotic cell cycle (GO:0051321)2.61102292
113folic acid-containing compound biosynthetic process (GO:0009396)2.60093734
114regulation of stem cell maintenance (GO:2000036)2.60016166
115protein localization to kinetochore (GO:0034501)2.59802463
116pinocytosis (GO:0006907)2.59794722
117male meiosis I (GO:0007141)2.58943260
118regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.58406950
119ribosomal small subunit biogenesis (GO:0042274)2.58302870
120regulation of early endosome to late endosome transport (GO:2000641)2.57989664
121cysteine metabolic process (GO:0006534)2.57070443
122regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.56054788
123pre-miRNA processing (GO:0031054)2.55966809
124regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55612668
125skeletal muscle tissue regeneration (GO:0043403)2.55596161
126mRNA transcription from RNA polymerase II promoter (GO:0042789)2.55116716
127chromosome condensation (GO:0030261)2.54680757
128folic acid metabolic process (GO:0046655)2.53882855
129positive regulation of cellular response to insulin stimulus (GO:1900078)2.53645994
130negative regulation of inclusion body assembly (GO:0090084)2.53466099
131negative regulation of anoikis (GO:2000811)2.51389101
132microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.50547985
133regulation of catenin import into nucleus (GO:0035412)2.49726552
134regulation of necroptotic process (GO:0060544)2.49678855
135regulation of SMAD protein import into nucleus (GO:0060390)2.49418050
136intracellular lipid transport (GO:0032365)2.49256517
137positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.49050284
1383-UTR-mediated mRNA stabilization (GO:0070935)2.47493592
139ventricular cardiac muscle cell development (GO:0055015)2.46205465
140protein hydroxylation (GO:0018126)2.45089196
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44331310
142positive regulation of protein oligomerization (GO:0032461)2.44243908
143regulation of p38MAPK cascade (GO:1900744)2.44108469
144meiotic nuclear division (GO:0007126)2.42791553
145regulation of glucose import in response to insulin stimulus (GO:2001273)2.42249176
146negative regulation of protein localization to plasma membrane (GO:1903077)2.41862065
147negative regulation of cardiac muscle tissue growth (GO:0055022)2.41857261
148negative regulation of heart growth (GO:0061117)2.41857261
149meiosis I (GO:0007127)2.41573924
150peptidyl-lysine dimethylation (GO:0018027)2.39483682
1514-hydroxyproline metabolic process (GO:0019471)2.39112146
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.39030653
153DNA damage induced protein phosphorylation (GO:0006975)2.38766435
154endocytic recycling (GO:0032456)2.38718134
155actin filament-based movement (GO:0030048)2.38610926
156gene silencing (GO:0016458)2.38341766
157attachment of spindle microtubules to kinetochore (GO:0008608)2.35899550
158negative regulation of histone methylation (GO:0031061)2.33596533
159histone H3-K9 demethylation (GO:0033169)2.33522388
160regulation of nucleobase-containing compound transport (GO:0032239)2.33196569
161regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.32215503
162hemidesmosome assembly (GO:0031581)2.30201446
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30149293
164myofibril assembly (GO:0030239)2.29991789
165response to inactivity (GO:0014854)2.29504293
166entrainment of circadian clock by photoperiod (GO:0043153)2.29473245
167positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.29347625
168regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.29347625
169regulation of NFAT protein import into nucleus (GO:0051532)2.28152119
170L-alpha-amino acid transmembrane transport (GO:1902475)2.26860364
171positive regulation of response to nutrient levels (GO:0032109)2.26310206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.46514913
2ZNF263_19887448_ChIP-Seq_K562_Human3.41918711
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01676905
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.83751928
5AR_21909140_ChIP-Seq_LNCAP_Human2.62972521
6E2F7_22180533_ChIP-Seq_HELA_Human2.53070092
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51896120
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.42342634
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.37179046
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30149909
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28945887
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.15580406
13ATF3_27146783_Chip-Seq_COLON_Human2.14087885
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.10887090
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05037308
16* RXR_22158963_ChIP-Seq_LIVER_Mouse2.02071804
17STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00388321
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93552272
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89466317
20* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79834287
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79759234
22KLF4_18555785_ChIP-Seq_MESCs_Mouse1.77383319
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.77303712
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76967517
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.74686912
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70939500
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70939500
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68560938
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66294882
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62430400
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60987200
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.58018963
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57718560
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55894389
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54196105
36CLOCK_20551151_ChIP-Seq_293T_Human1.53827748
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53605917
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52887979
39KDM2B_26808549_Chip-Seq_K562_Human1.51783508
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51471892
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50028539
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47379384
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46898059
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43784663
45GATA6_25053715_ChIP-Seq_YYC3_Human1.43496159
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43379690
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.42905847
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41969961
49VDR_21846776_ChIP-Seq_THP-1_Human1.41613648
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38719677
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38044542
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.37791390
53* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35126715
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35014077
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34844637
56MYC_22102868_ChIP-Seq_BL_Human1.34722275
57* NANOG_21062744_ChIP-ChIP_HESCs_Human1.33011765
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32479283
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32461080
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32316582
61* CHD1_26751641_Chip-Seq_LNCaP_Human1.30328361
62* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30113874
63RACK7_27058665_Chip-Seq_MCF-7_Human1.29023766
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29011768
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28773390
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27982892
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27545510
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26943625
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26583531
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.25830165
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.25830165
72* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24784510
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24038928
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22827252
75* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22599780
76* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22376030
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21026620
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20908530
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20695419
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.20651359
81KDM5A_27292631_Chip-Seq_BREAST_Human1.20344330
82VDR_24763502_ChIP-Seq_THP-1_Human1.18140734
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16342211
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15619614
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13733711
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.13170538
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12118464
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12089157
89GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11062040
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.10799526
91TFEB_21752829_ChIP-Seq_HELA_Human1.10020448
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09487142
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08778130
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08735766
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08533680
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.07990546
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.07979810
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07426100
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07397719
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07397719
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07397719
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06882667
103KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06625948
104* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04744555
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03699056
106KDM2B_26808549_Chip-Seq_DND41_Human1.03634685
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03615682
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.03557043
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03525818
110* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.03442667
111RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02961364
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02845895
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02813612
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02486169
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00885077
116* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00499816
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.00489834
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99447591
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.98820411
120* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98542599
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98382907
122PU_27001747_Chip-Seq_BMDM_Mouse0.98379998
123* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98273773
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97445906
125* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.94734161
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94484806
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94192829
128CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93993894
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.93734294
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93732849
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92942592
132* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92870534
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92307787
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92181376
135NCOR1_26117541_ChIP-Seq_K562_Human0.91754750
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91280311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.16850630
2MP0003705_abnormal_hypodermis_morpholog2.88288316
3MP0004185_abnormal_adipocyte_glucose2.75509692
4MP0000750_abnormal_muscle_regeneration2.32758891
5MP0003718_maternal_effect2.29095154
6MP0002877_abnormal_melanocyte_morpholog2.17085786
7MP0003693_abnormal_embryo_hatching2.15765633
8MP0004957_abnormal_blastocyst_morpholog2.13660546
9MP0004087_abnormal_muscle_fiber2.08778076
10MP0004145_abnormal_muscle_electrophysio2.02285886
11MP0003221_abnormal_cardiomyocyte_apopto1.93174815
12MP0005076_abnormal_cell_differentiation1.92740885
13MP0004510_myositis1.91325610
14MP0010352_gastrointestinal_tract_polyps1.89216596
15MP0002106_abnormal_muscle_physiology1.88888147
16MP0000733_abnormal_muscle_development1.88764377
17MP0000749_muscle_degeneration1.86765955
18MP0005666_abnormal_adipose_tissue1.84982463
19MP0002269_muscular_atrophy1.81861292
20MP0005409_darkened_coat_color1.81031269
21MP0003091_abnormal_cell_migration1.78529436
22MP0009379_abnormal_foot_pigmentation1.78146518
23MP0004130_abnormal_muscle_cell1.77903605
24MP0002837_dystrophic_cardiac_calcinosis1.73317443
25MP0000751_myopathy1.72265900
26MP0010234_abnormal_vibrissa_follicle1.72140685
27MP0003111_abnormal_nucleus_morphology1.69299182
28MP0004036_abnormal_muscle_relaxation1.67675614
29MP0004233_abnormal_muscle_weight1.64365707
30MP0005451_abnormal_body_composition1.64303489
31MP0001730_embryonic_growth_arrest1.56542851
32MP0000759_abnormal_skeletal_muscle1.54744053
33MP0004084_abnormal_cardiac_muscle1.53682345
34MP0000747_muscle_weakness1.53587564
35MP0003077_abnormal_cell_cycle1.50186491
36MP0010630_abnormal_cardiac_muscle1.48749573
37MP0002139_abnormal_hepatobiliary_system1.46469022
38MP0005330_cardiomyopathy1.42402083
39MP0003567_abnormal_fetal_cardiomyocyte1.41924692
40MP0005369_muscle_phenotype1.41359685
41MP0005380_embryogenesis_phenotype1.37378790
42MP0001672_abnormal_embryogenesis/_devel1.37378790
43MP0003566_abnormal_cell_adhesion1.33844300
44MP0010094_abnormal_chromosome_stability1.31216284
45MP0003984_embryonic_growth_retardation1.30563889
46MP0002088_abnormal_embryonic_growth/wei1.29680319
47MP0005257_abnormal_intraocular_pressure1.28851083
48MP0001697_abnormal_embryo_size1.28312556
49MP0009840_abnormal_foam_cell1.25196974
50MP0005395_other_phenotype1.23230868
51MP0000858_altered_metastatic_potential1.22562225
52MP0002086_abnormal_extraembryonic_tissu1.20485095
53MP0002084_abnormal_developmental_patter1.20146541
54MP0003806_abnormal_nucleotide_metabolis1.18815320
55MP0000350_abnormal_cell_proliferation1.18273570
56MP0005620_abnormal_muscle_contractility1.17250668
57MP0002396_abnormal_hematopoietic_system1.17114343
58MP0004947_skin_inflammation1.12329938
59MP0010307_abnormal_tumor_latency1.12323918
60MP0000678_abnormal_parathyroid_gland1.11977486
61MP0002085_abnormal_embryonic_tissue1.11877836
62MP0005375_adipose_tissue_phenotype1.11535101
63MP0004197_abnormal_fetal_growth/weight/1.10867449
64MP0000490_abnormal_crypts_of1.10146419
65MP0002332_abnormal_exercise_endurance1.09876020
66MP0000762_abnormal_tongue_morphology1.09866213
67MP0001849_ear_inflammation1.09748191
68MP0004484_altered_response_of1.07147225
69MP0008260_abnormal_autophagy1.06931495
70MP0010030_abnormal_orbit_morphology1.05728237
71MP0008877_abnormal_DNA_methylation1.05235566
72MP0001216_abnormal_epidermal_layer1.04989840
73MP0002060_abnormal_skin_morphology1.03943489
74MP0002254_reproductive_system_inflammat1.03848886
75MP0004264_abnormal_extraembryonic_tissu1.02902131
76MP0003828_pulmonary_edema1.02161509
77MP0002971_abnormal_brown_adipose1.01652964
78MP0008057_abnormal_DNA_replication1.01579779
79MP0002998_abnormal_bone_remodeling1.01334749
80MP0001929_abnormal_gametogenesis0.99723106
81MP0003303_peritoneal_inflammation0.96283899
82MP0001544_abnormal_cardiovascular_syste0.96214120
83MP0005385_cardiovascular_system_phenoty0.96214120
84MP0003453_abnormal_keratinocyte_physiol0.96159638
85MP0002796_impaired_skin_barrier0.96012822
86MP0000003_abnormal_adipose_tissue0.95669968
87MP0003950_abnormal_plasma_membrane0.95446834
88MP0003656_abnormal_erythrocyte_physiolo0.95192551
89MP0004808_abnormal_hematopoietic_stem0.94418711
90MP0005248_abnormal_Harderian_gland0.92163715
91MP0000579_abnormal_nail_morphology0.91540331
92MP0002089_abnormal_postnatal_growth/wei0.91497136
93MP0002080_prenatal_lethality0.90083276
94MP0005365_abnormal_bile_salt0.89817090
95MP0004215_abnormal_myocardial_fiber0.89138051
96MP0005085_abnormal_gallbladder_physiolo0.88271409
97MP0008932_abnormal_embryonic_tissue0.88234803
98MP0002210_abnormal_sex_determination0.88033955
99MP0000266_abnormal_heart_morphology0.87992276
100MP0006036_abnormal_mitochondrial_physio0.85773903
101MP0001851_eye_inflammation0.85699208
102MP0000627_abnormal_mammary_gland0.85543066
103MP0009672_abnormal_birth_weight0.85371097
104MP0001348_abnormal_lacrimal_gland0.85080693
105MP0005621_abnormal_cell_physiology0.84439486
106MP0005187_abnormal_penis_morphology0.82362282
107MP0005623_abnormal_meninges_morphology0.82332236
108MP0003699_abnormal_female_reproductive0.82006237
109MP0003937_abnormal_limbs/digits/tail_de0.81053853
110MP0006138_congestive_heart_failure0.80833443
111MP0002972_abnormal_cardiac_muscle0.80286836
112MP0002163_abnormal_gland_morphology0.80059475
113MP0005023_abnormal_wound_healing0.79462915
114MP0001299_abnormal_eye_distance/0.78812272
115MP0005360_urolithiasis0.78616442
116MP0002896_abnormal_bone_mineralization0.77507206
117MP0000653_abnormal_sex_gland0.77472338
118MP0001915_intracranial_hemorrhage0.76993789
119MP0008775_abnormal_heart_ventricle0.74876611
120MP0001340_abnormal_eyelid_morphology0.74395227
121MP0000609_abnormal_liver_physiology0.74072232
122MP0009053_abnormal_anal_canal0.73556523
123MP0001145_abnormal_male_reproductive0.72988647
124MP0003300_gastrointestinal_ulcer0.71393163
125MP0005670_abnormal_white_adipose0.70359412
126MP0001853_heart_inflammation0.70233994
127MP0003123_paternal_imprinting0.68903343
128MP0003941_abnormal_skin_development0.68706679
129MP0002925_abnormal_cardiovascular_devel0.67254717
130MP0005501_abnormal_skin_physiology0.65703267
131MP0001881_abnormal_mammary_gland0.63035577

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.18397029
2Muscle fiber inclusion bodies (HP:0100299)5.13678688
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.00991474
4Exercise-induced muscle cramps (HP:0003710)4.68336948
5Nemaline bodies (HP:0003798)4.37413025
6Exercise-induced myalgia (HP:0003738)4.36686332
7Hyporeflexia of lower limbs (HP:0002600)4.28549487
8Increased connective tissue (HP:0009025)4.19682217
9Difficulty climbing stairs (HP:0003551)3.96681517
10Difficulty running (HP:0009046)3.95405190
11Male infertility (HP:0003251)3.92042713
12Type 1 muscle fiber predominance (HP:0003803)3.84677655
13Myopathic facies (HP:0002058)3.74401260
14Muscle hypertrophy of the lower extremities (HP:0008968)3.61366741
15Ulnar deviation of the wrist (HP:0003049)3.61038485
16Distal lower limb amyotrophy (HP:0008944)3.48219500
17Centrally nucleated skeletal muscle fibers (HP:0003687)3.43165399
18Calf muscle hypertrophy (HP:0008981)3.41069503
19Distal arthrogryposis (HP:0005684)3.36806541
20Round ear (HP:0100830)3.35910404
21Abnormality of the left ventricular outflow tract (HP:0011103)3.29734734
22Subaortic stenosis (HP:0001682)3.29734734
23Myoglobinuria (HP:0002913)3.24636583
24Sudden death (HP:0001699)3.20717789
25Hyperglycemia (HP:0003074)3.20230047
26Rhabdomyolysis (HP:0003201)3.09730450
27Areflexia of lower limbs (HP:0002522)2.94767008
28Lower limb amyotrophy (HP:0007210)2.93411352
29Calcaneovalgus deformity (HP:0001848)2.82973233
30Right ventricular cardiomyopathy (HP:0011663)2.80615891
31EMG: myopathic abnormalities (HP:0003458)2.73125061
32Deformed tarsal bones (HP:0008119)2.70971944
33Asymmetric septal hypertrophy (HP:0001670)2.69129170
34Hypoplastic ischia (HP:0003175)2.67580390
35Bundle branch block (HP:0011710)2.65597068
36Ventricular tachycardia (HP:0004756)2.65256739
37Rectal prolapse (HP:0002035)2.65199542
38Achilles tendon contracture (HP:0001771)2.64682333
39Abnormality of the Achilles tendon (HP:0005109)2.57398549
40Multiple enchondromatosis (HP:0005701)2.56462629
41Increased variability in muscle fiber diameter (HP:0003557)2.55789402
42Abnormality of the calf musculature (HP:0001430)2.49506179
43EMG: neuropathic changes (HP:0003445)2.49452100
44Insulin-resistant diabetes mellitus (HP:0000831)2.46196705
45Cortical dysplasia (HP:0002539)2.44590375
46Neonatal hypoglycemia (HP:0001998)2.43818684
47Muscle stiffness (HP:0003552)2.40703468
48Hypoalphalipoproteinemia (HP:0003233)2.36385477
49Atrioventricular block (HP:0001678)2.30646348
50Abnormality of the ischium (HP:0003174)2.28866840
51Pelvic girdle muscle weakness (HP:0003749)2.28829068
52Absent phalangeal crease (HP:0006109)2.27366265
53Rimmed vacuoles (HP:0003805)2.25086120
54Premature ovarian failure (HP:0008209)2.24313336
55Frequent falls (HP:0002359)2.20420367
56Polycythemia (HP:0001901)2.18451836
57Syringomyelia (HP:0003396)2.17596054
58Spinal cord lesions (HP:0100561)2.17596054
59Weak cry (HP:0001612)2.15733046
60Progressive muscle weakness (HP:0003323)2.12082635
61Facial hemangioma (HP:0000329)2.11504283
62Neck muscle weakness (HP:0000467)2.10237734
63Myotonia (HP:0002486)2.07224220
64Myocardial infarction (HP:0001658)2.05782658
65Dysmetric saccades (HP:0000641)2.04985935
66Abnormality of the hip-girdle musculature (HP:0001445)2.04829998
67Abnormality of the musculature of the pelvis (HP:0001469)2.04829998
68Abnormality of lateral ventricle (HP:0030047)2.04005949
69Biliary tract neoplasm (HP:0100574)2.03700722
70Abnormal atrioventricular conduction (HP:0005150)2.00248090
71Hyperacusis (HP:0010780)1.98358693
72Abnormality of the calcaneus (HP:0008364)1.96681092
73Abnormality of the salivary glands (HP:0010286)1.96039980
74Osteolytic defects of the phalanges of the hand (HP:0009771)1.95358346
75Osteolytic defects of the hand bones (HP:0009699)1.95358346
76Fatigue (HP:0012378)1.94796259
77Arterial tortuosity (HP:0005116)1.94063544
78Malignant hyperthermia (HP:0002047)1.93808863
79Lipoatrophy (HP:0100578)1.93298405
80Distal lower limb muscle weakness (HP:0009053)1.92951271
81Nausea (HP:0002018)1.92900574
82Heart block (HP:0012722)1.91768970
83Selective tooth agenesis (HP:0001592)1.91616930
84Foot dorsiflexor weakness (HP:0009027)1.90633201
85Breast hypoplasia (HP:0003187)1.90449304
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89928983
87Slender build (HP:0001533)1.88752280
88Shoulder girdle muscle weakness (HP:0003547)1.88435143
89Popliteal pterygium (HP:0009756)1.88020822
90Gout (HP:0001997)1.87692055
91Lip pit (HP:0100267)1.86754177
92Genu recurvatum (HP:0002816)1.84982910
93Hyperglycinemia (HP:0002154)1.84223557
94Protrusio acetabuli (HP:0003179)1.83848914
95Abnormal finger flexion creases (HP:0006143)1.82990407
96Hip contracture (HP:0003273)1.81305590
97Global brain atrophy (HP:0002283)1.80550070
98Reduced subcutaneous adipose tissue (HP:0003758)1.80268958
99Generalized muscle weakness (HP:0003324)1.80160945
100Hyperkalemia (HP:0002153)1.79759468
101Amniotic constriction ring (HP:0009775)1.79362622
102Abnormality of placental membranes (HP:0011409)1.79362622
103Bulbar palsy (HP:0001283)1.78380842
104Secondary amenorrhea (HP:0000869)1.76704906
105Hypoglycemic coma (HP:0001325)1.76220541
106Flat acetabular roof (HP:0003180)1.76134351
107Ankle contracture (HP:0006466)1.76080905
108Abnormal cartilage morphology (HP:0002763)1.75680710
109Progressive external ophthalmoplegia (HP:0000590)1.75581506
110Hyperglycinuria (HP:0003108)1.75279892
111Limb-girdle muscle atrophy (HP:0003797)1.73345552
112Increased purine levels (HP:0004368)1.73186065
113Hyperuricemia (HP:0002149)1.73186065
114Abnormality of skeletal muscle fiber size (HP:0012084)1.73174849
115Asymmetry of the thorax (HP:0001555)1.72624757
116Abnormality of the foot musculature (HP:0001436)1.72204001
117Proximal amyotrophy (HP:0007126)1.72071068
118Tetraparesis (HP:0002273)1.71777179
119Metaphyseal cupping (HP:0003021)1.71249765
120Mildly elevated creatine phosphokinase (HP:0008180)1.70661755
121Segmental peripheral demyelination/remyelination (HP:0003481)1.70598888
122Infertility (HP:0000789)1.68937095
123Hypolipoproteinemia (HP:0010981)1.68927223
124Vertebral arch anomaly (HP:0008438)1.68720904
125Scapular winging (HP:0003691)1.68554230
126Fatigable weakness (HP:0003473)1.68173547
127Abnormality of the neuromuscular junction (HP:0003398)1.68173547
128Deep palmar crease (HP:0006191)1.66492310
129Papillary thyroid carcinoma (HP:0002895)1.66447845
130Wrist flexion contracture (HP:0001239)1.65337569
131Ankyloglossia (HP:0010296)1.65030603
132Short nail (HP:0001799)1.64876577
133Spinal rigidity (HP:0003306)1.64741329
134Deep venous thrombosis (HP:0002625)1.63720877
135Premature rupture of membranes (HP:0001788)1.63240708
136Axonal loss (HP:0003447)1.62564561
137Vascular tortuosity (HP:0004948)1.62322635
138Overgrowth (HP:0001548)1.61056552
139Obstructive sleep apnea (HP:0002870)1.60899273
140Facial diplegia (HP:0001349)1.60674225
141Trismus (HP:0000211)1.60209550
142Subacute progressive viral hepatitis (HP:0006572)1.56492168
143Vertebral compression fractures (HP:0002953)1.56156827
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56055064
145Pterygium (HP:0001059)1.55305330
146Arnold-Chiari malformation (HP:0002308)1.55246426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.40065295
2IRAK33.46366206
3TRIB33.29684299
4LATS23.28861758
5TTN2.84449142
6STK38L2.72648728
7MAP3K132.72540005
8PDK32.64296272
9PDK42.64296272
10STK32.49163107
11PRPF4B2.35992083
12MAP3K62.33924133
13OBSCN2.20249297
14DMPK2.14348981
15SIK12.12150590
16PKN22.05497513
17CDK122.00161839
18EPHA22.00119292
19SMG12.00059252
20NEK21.82877418
21PDK21.76610436
22ERBB41.76446053
23TTK1.75948725
24TAOK11.57279383
25EEF2K1.55696761
26NEK11.48101474
27MAP3K141.47809684
28RIPK11.42352128
29IRAK21.36948482
30KSR21.35760698
31BRAF1.33607544
32CDK61.31477446
33STK241.30500522
34ARAF1.30125351
35WEE11.29123531
36STK101.27910550
37PAK41.25474800
38PRKD31.25293243
39ICK1.24986153
40NEK91.22511784
41MAP3K31.21225293
42CDK41.19172039
43MAP3K51.17112936
44CDC71.16279963
45MAP3K11.12471171
46BCKDK1.12351688
47MST1R1.11311377
48SGK31.10287210
49NME21.10198238
50IRAK41.09562449
51PHKG21.09230303
52PHKG11.09230303
53VRK21.08248286
54MAP3K21.06412734
55ABL21.05959929
56MAP2K31.04846944
57MAP3K81.02125601
58MTOR1.01149527
59MARK20.98941369
60CHEK20.98555996
61PLK40.97019841
62CDK190.96870121
63STK380.95349155
64PDGFRA0.93275260
65KSR10.90077194
66MST40.89165045
67NME10.87927611
68PNCK0.87597416
69PRKAA10.86316804
70TAOK20.86075331
71TYRO30.84403718
72BMX0.83873187
73PINK10.83579329
74MELK0.83066022
75RIPK40.82806238
76CDK90.82782304
77WNK10.82643238
78ACVR1B0.81581162
79MOS0.80846399
80TAF10.79123312
81TAOK30.79087141
82ALK0.78653731
83RPS6KA40.78630222
84MAP3K110.77930241
85IRAK10.75979496
86DYRK30.75205521
87ERN10.75018946
88PTK60.71607700
89PDPK10.69409146
90AURKB0.68858693
91LRRK20.68752346
92PRKAA20.68398574
93MUSK0.67964618
94SIK30.67200358
95PLK10.66669271
96CDK80.66316159
97MAPK120.65855352
98FGFR40.64828843
99RPS6KB20.64785543
100PRKG20.60534370
101TRPM70.58518707
102MAP2K40.57760977
103PIM10.57533860
104AKT30.56967384
105MAPKAPK30.56713317
106JAK30.56684149
107BRSK20.56137020
108DDR20.53618170
109CDK70.53078471
110TGFBR20.52025542
111ILK0.51018262
112PTK20.50665344
113MAP3K70.48467502
114CHEK10.48123979
115PIK3CG0.48033048
116MAP3K90.46097410
117MARK30.45892850
118PDGFRB0.45868073
119FGR0.44814512
120PAK20.44665808
121FRK0.44051550
122RET0.43550054
123CAMK1D0.41825369
124RAF10.41365804
125PIK3CA0.41356199
126MAPK110.40275938
127AURKA0.40097816
128EIF2AK10.39667971
129PDK10.39491926
130MAP3K120.39138391
131DYRK1B0.39031466
132MAP3K100.38770535
133RPS6KA10.38613932
134HIPK20.38278130
135STK40.38047251
136CAMK1G0.36682377
137MET0.36214007
138EIF2AK30.35665956
139SGK20.35347366
140PRKCI0.35224142
141FGFR30.35052144
142ATM0.34729415
143PRKD20.34079427
144YES10.33736783
145CDK20.33660541
146RPS6KB10.33244566
147GSK3A0.32045100
148AKT20.30031041
149CSNK1E0.29328669

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007502.17106091
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06379804
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01559210
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96135529
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94699360
6RNA transport_Homo sapiens_hsa030131.91318117
7mTOR signaling pathway_Homo sapiens_hsa041501.89912964
8Cell cycle_Homo sapiens_hsa041101.86305650
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85853079
10Dorso-ventral axis formation_Homo sapiens_hsa043201.84836580
11Propanoate metabolism_Homo sapiens_hsa006401.83954750
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76911681
13B cell receptor signaling pathway_Homo sapiens_hsa046621.71825864
14Arginine biosynthesis_Homo sapiens_hsa002201.59904313
15Carbon metabolism_Homo sapiens_hsa012001.54373955
16Adherens junction_Homo sapiens_hsa045201.50961329
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49172222
18AMPK signaling pathway_Homo sapiens_hsa041521.48368939
19Fatty acid degradation_Homo sapiens_hsa000711.44047480
20ErbB signaling pathway_Homo sapiens_hsa040121.43496419
21Insulin resistance_Homo sapiens_hsa049311.39093603
22Fatty acid biosynthesis_Homo sapiens_hsa000611.38364159
23TGF-beta signaling pathway_Homo sapiens_hsa043501.37912610
24Neurotrophin signaling pathway_Homo sapiens_hsa047221.37673156
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36959831
26Long-term potentiation_Homo sapiens_hsa047201.36198800
27Nitrogen metabolism_Homo sapiens_hsa009101.33374848
28Renal cell carcinoma_Homo sapiens_hsa052111.32795306
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31601800
30Insulin signaling pathway_Homo sapiens_hsa049101.31193461
31Biosynthesis of amino acids_Homo sapiens_hsa012301.30847390
32p53 signaling pathway_Homo sapiens_hsa041151.30738273
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.28930218
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28717887
35Basal transcription factors_Homo sapiens_hsa030221.26204042
36Bladder cancer_Homo sapiens_hsa052191.25680278
37Small cell lung cancer_Homo sapiens_hsa052221.25292424
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20599953
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18745259
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.17561862
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16168517
42MicroRNAs in cancer_Homo sapiens_hsa052061.16111911
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15669968
44Osteoclast differentiation_Homo sapiens_hsa043801.15518839
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.14896520
46Circadian rhythm_Homo sapiens_hsa047101.14498989
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11508606
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10801742
49Glucagon signaling pathway_Homo sapiens_hsa049221.10741409
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10534691
51Hippo signaling pathway_Homo sapiens_hsa043901.08651684
52MAPK signaling pathway_Homo sapiens_hsa040101.08498155
53Tight junction_Homo sapiens_hsa045301.08030992
54Fatty acid metabolism_Homo sapiens_hsa012121.06408603
55Hepatitis C_Homo sapiens_hsa051601.06121333
56Thyroid cancer_Homo sapiens_hsa052161.05810465
57TNF signaling pathway_Homo sapiens_hsa046681.05683297
58Chronic myeloid leukemia_Homo sapiens_hsa052201.05507956
59Selenocompound metabolism_Homo sapiens_hsa004501.05253766
60Shigellosis_Homo sapiens_hsa051311.04324325
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03368557
62FoxO signaling pathway_Homo sapiens_hsa040681.03159077
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02201938
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02184767
65PPAR signaling pathway_Homo sapiens_hsa033201.01399586
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00823550
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00487846
68Pentose phosphate pathway_Homo sapiens_hsa000301.00134512
69Pyruvate metabolism_Homo sapiens_hsa006200.99191679
70Pancreatic cancer_Homo sapiens_hsa052120.98517218
71Influenza A_Homo sapiens_hsa051640.98387925
72Sulfur relay system_Homo sapiens_hsa041220.96857217
73GnRH signaling pathway_Homo sapiens_hsa049120.95085096
74VEGF signaling pathway_Homo sapiens_hsa043700.94969391
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94653534
76RNA degradation_Homo sapiens_hsa030180.93795396
77Prostate cancer_Homo sapiens_hsa052150.93215455
78Viral myocarditis_Homo sapiens_hsa054160.92869997
79Oocyte meiosis_Homo sapiens_hsa041140.92297656
80mRNA surveillance pathway_Homo sapiens_hsa030150.91809061
81Lysine degradation_Homo sapiens_hsa003100.91498143
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.91289882
83Hepatitis B_Homo sapiens_hsa051610.90674969
84Focal adhesion_Homo sapiens_hsa045100.90289583
85Colorectal cancer_Homo sapiens_hsa052100.90082574
86Dilated cardiomyopathy_Homo sapiens_hsa054140.88117741
87T cell receptor signaling pathway_Homo sapiens_hsa046600.86874602
88Fat digestion and absorption_Homo sapiens_hsa049750.86837655
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85116056
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84528011
91Apoptosis_Homo sapiens_hsa042100.83971012
92Proteoglycans in cancer_Homo sapiens_hsa052050.83873961
93Folate biosynthesis_Homo sapiens_hsa007900.82992750
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82754384
95Melanoma_Homo sapiens_hsa052180.81828508
96Toxoplasmosis_Homo sapiens_hsa051450.80466478
97HIF-1 signaling pathway_Homo sapiens_hsa040660.80106956
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80039510
99Galactose metabolism_Homo sapiens_hsa000520.78958719
100Notch signaling pathway_Homo sapiens_hsa043300.78891346
101Prolactin signaling pathway_Homo sapiens_hsa049170.76263178
102Endocytosis_Homo sapiens_hsa041440.72858463
103Arginine and proline metabolism_Homo sapiens_hsa003300.72157378
104Pathways in cancer_Homo sapiens_hsa052000.71971768
105Endometrial cancer_Homo sapiens_hsa052130.71308539
106Estrogen signaling pathway_Homo sapiens_hsa049150.70955757
107Acute myeloid leukemia_Homo sapiens_hsa052210.69958135
108Prion diseases_Homo sapiens_hsa050200.69238398
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.68110245
110Tuberculosis_Homo sapiens_hsa051520.67981643
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67564059
112One carbon pool by folate_Homo sapiens_hsa006700.67288713
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.66843278
114Measles_Homo sapiens_hsa051620.65535372
115Viral carcinogenesis_Homo sapiens_hsa052030.65221683
116Starch and sucrose metabolism_Homo sapiens_hsa005000.64956887
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64294257
118Legionellosis_Homo sapiens_hsa051340.64146637
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63886783
120Amoebiasis_Homo sapiens_hsa051460.63396658
121Leishmaniasis_Homo sapiens_hsa051400.63326979
122Wnt signaling pathway_Homo sapiens_hsa043100.61787810
123Inositol phosphate metabolism_Homo sapiens_hsa005620.61106915
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61105400
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61022471
126Non-small cell lung cancer_Homo sapiens_hsa052230.60760810
127Salmonella infection_Homo sapiens_hsa051320.60041391
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59132905
129Linoleic acid metabolism_Homo sapiens_hsa005910.57300005
130Tryptophan metabolism_Homo sapiens_hsa003800.57172346
131RNA polymerase_Homo sapiens_hsa030200.56829864
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56052097
133Chemokine signaling pathway_Homo sapiens_hsa040620.55885540
134Fructose and mannose metabolism_Homo sapiens_hsa000510.55370325
135Glycerolipid metabolism_Homo sapiens_hsa005610.55111126
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.53466593
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53405501
138ECM-receptor interaction_Homo sapiens_hsa045120.53321464
139HTLV-I infection_Homo sapiens_hsa051660.53303485
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52445628
141Glioma_Homo sapiens_hsa052140.48593545
142Ovarian steroidogenesis_Homo sapiens_hsa049130.47757407
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.47223033
144Hedgehog signaling pathway_Homo sapiens_hsa043400.46154891
145Choline metabolism in cancer_Homo sapiens_hsa052310.46105755
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46018065
147Epstein-Barr virus infection_Homo sapiens_hsa051690.44703261

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