KCNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)8.43966430
2central nervous system myelination (GO:0022010)7.46145382
3axon ensheathment in central nervous system (GO:0032291)7.46145382
4sodium ion export (GO:0071436)6.28821362
5neuronal action potential propagation (GO:0019227)5.37174131
6positive regulation of synapse maturation (GO:0090129)5.20824010
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.81353023
8neurotransmitter transport (GO:0006836)4.71854793
9ensheathment of neurons (GO:0007272)4.69514010
10axon ensheathment (GO:0008366)4.69514010
11myelination (GO:0042552)4.67382582
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.63720621
13fatty acid elongation (GO:0030497)4.53388468
14regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.41188465
15potassium ion homeostasis (GO:0055075)4.38235112
16long-chain fatty acid biosynthetic process (GO:0042759)4.29245696
17postsynaptic membrane organization (GO:0001941)4.27139564
18potassium ion import (GO:0010107)4.26857221
19regulation of neurotransmitter levels (GO:0001505)4.21270483
20neuron cell-cell adhesion (GO:0007158)4.20009682
21establishment of mitochondrion localization (GO:0051654)4.16876090
22neurotransmitter-gated ion channel clustering (GO:0072578)4.14139010
23neurofilament cytoskeleton organization (GO:0060052)4.08729494
24regulation of synapse maturation (GO:0090128)4.08380078
25cellular sodium ion homeostasis (GO:0006883)4.07364081
26regulation of neurotransmitter secretion (GO:0046928)4.07203720
27presynaptic membrane organization (GO:0097090)4.07089992
28cell communication by electrical coupling (GO:0010644)4.06533688
29proline transport (GO:0015824)4.06507458
30synaptic vesicle maturation (GO:0016188)3.96412534
31synaptic vesicle endocytosis (GO:0048488)3.94911675
32regulation of vesicle fusion (GO:0031338)3.93562715
33synaptic vesicle exocytosis (GO:0016079)3.88622096
34presynaptic membrane assembly (GO:0097105)3.87417465
35L-amino acid import (GO:0043092)3.83385860
36transmission of nerve impulse (GO:0019226)3.79742808
37negative regulation of neurotransmitter transport (GO:0051589)3.79700316
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77377409
39negative regulation of neurotransmitter secretion (GO:0046929)3.75321405
40regulation of neurotransmitter transport (GO:0051588)3.70958737
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70465967
42adult walking behavior (GO:0007628)3.66767098
43regulation of ARF protein signal transduction (GO:0032012)3.64610403
44glutamate secretion (GO:0014047)3.55097497
45vocalization behavior (GO:0071625)3.54128488
46positive regulation of dendritic spine development (GO:0060999)3.53414445
47layer formation in cerebral cortex (GO:0021819)3.51774904
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.50027141
49positive regulation of neurotransmitter secretion (GO:0001956)3.47707512
50neurotransmitter uptake (GO:0001504)3.47060925
51regulation of synapse structural plasticity (GO:0051823)3.47030853
52auditory behavior (GO:0031223)3.44206897
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43156543
54locomotory exploration behavior (GO:0035641)3.42593763
55serotonin metabolic process (GO:0042428)3.41269889
56cell differentiation in hindbrain (GO:0021533)3.40836177
57protein localization to synapse (GO:0035418)3.40173353
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.39159056
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35665166
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35203456
61positive regulation of neurotransmitter transport (GO:0051590)3.34649637
62regulation of synaptic vesicle exocytosis (GO:2000300)3.34331723
63apical protein localization (GO:0045176)3.33937520
64myelin maintenance (GO:0043217)3.33490982
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.30752631
66cell communication involved in cardiac conduction (GO:0086065)3.29201334
67neuron recognition (GO:0008038)3.28454187
68glutamate receptor signaling pathway (GO:0007215)3.28304830
69negative regulation of protein localization to cell surface (GO:2000009)3.27971757
70neuronal ion channel clustering (GO:0045161)3.27715708
71neuromuscular process controlling posture (GO:0050884)3.26546242
72* synaptic transmission (GO:0007268)3.25552675
73regulation of neuronal synaptic plasticity (GO:0048168)3.24291185
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.23553894
75regulation of synaptic transmission (GO:0050804)3.23316040
76neuromuscular process (GO:0050905)3.22683584
77long-term synaptic potentiation (GO:0060291)3.21444486
78cerebellar granule cell differentiation (GO:0021707)3.20807817
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20436895
80neuron-neuron synaptic transmission (GO:0007270)3.18870022
81gamma-aminobutyric acid transport (GO:0015812)3.18824306
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.18569373
83synaptic transmission, glutamatergic (GO:0035249)3.18447700
84detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.17868109
85detection of temperature stimulus involved in sensory perception (GO:0050961)3.17868109
86cell migration in hindbrain (GO:0021535)3.17542739
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.17470787
88neuromuscular synaptic transmission (GO:0007274)3.14906945
89response to auditory stimulus (GO:0010996)3.12968918
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12079548
91signal release (GO:0023061)3.11977876
92establishment of synaptic vesicle localization (GO:0097480)3.08712324
93synaptic vesicle transport (GO:0048489)3.08712324
94axon development (GO:0061564)3.07107262
95acidic amino acid transport (GO:0015800)3.07080114
96regulation of dendritic spine morphogenesis (GO:0061001)3.05092082
97axonal fasciculation (GO:0007413)3.04593979
98detection of calcium ion (GO:0005513)3.04298862
99nerve growth factor signaling pathway (GO:0038180)3.00456427
100vesicle docking involved in exocytosis (GO:0006904)2.99930509
101detection of temperature stimulus (GO:0016048)2.99908108
102cellular potassium ion homeostasis (GO:0030007)2.99742816
103oligodendrocyte differentiation (GO:0048709)2.99463960
104negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.98906750
105mitochondrion transport along microtubule (GO:0047497)2.96625840
106establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.96625840
107response to methylmercury (GO:0051597)2.94964676
108glycerophospholipid catabolic process (GO:0046475)2.91976363
109asymmetric protein localization (GO:0008105)2.91518222
110regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91477382
111dendritic spine morphogenesis (GO:0060997)2.90436288
112positive regulation of potassium ion transport (GO:0043268)2.88617125
113exploration behavior (GO:0035640)2.88589794
114glycine transport (GO:0015816)2.88257782
115regulation of voltage-gated calcium channel activity (GO:1901385)2.87582645
116amino acid import (GO:0043090)2.84921495
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84693707
118regulation of long-term neuronal synaptic plasticity (GO:0048169)2.84681834
119negative regulation of axonogenesis (GO:0050771)2.84651532
120neuromuscular process controlling balance (GO:0050885)2.84642088
121peptidyl-tyrosine autophosphorylation (GO:0038083)2.84557279
122regulation of synaptic vesicle transport (GO:1902803)2.84276563
123regulation of glutamate receptor signaling pathway (GO:1900449)2.82703188
124dendrite morphogenesis (GO:0048813)2.78405642
125membrane depolarization during action potential (GO:0086010)2.76131921
126positive regulation of membrane potential (GO:0045838)2.75743027
127organelle transport along microtubule (GO:0072384)2.74795767
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72890408
129regulation of postsynaptic membrane potential (GO:0060078)2.72319808
130regulation of dendritic spine development (GO:0060998)2.71367737
131membrane hyperpolarization (GO:0060081)2.71284992
132regulation of collateral sprouting (GO:0048670)2.70228515
133cerebellar Purkinje cell differentiation (GO:0021702)2.69891388
134calcium-mediated signaling using intracellular calcium source (GO:0035584)2.68925688
135regulation of synaptic plasticity (GO:0048167)2.68150900
136neurotransmitter secretion (GO:0007269)2.67091061
137eye photoreceptor cell differentiation (GO:0001754)2.65653781
138photoreceptor cell differentiation (GO:0046530)2.65653781
139membrane depolarization (GO:0051899)2.65477844
140positive regulation of potassium ion transmembrane transport (GO:1901381)2.65039207
141astrocyte development (GO:0014002)2.65038103
142negative regulation of dendrite morphogenesis (GO:0050774)2.61184839
143cerebral cortex radially oriented cell migration (GO:0021799)2.61119287
144neuron remodeling (GO:0016322)2.61027042
145neuronal action potential (GO:0019228)2.60907412
146long-term memory (GO:0007616)2.60508731
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60084754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61310006
2GBX2_23144817_ChIP-Seq_PC3_Human3.77722922
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99785732
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97230395
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93955887
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62513327
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62513327
8* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47456633
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42738630
10TAF15_26573619_Chip-Seq_HEK293_Human2.40885018
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39872013
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38755183
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35087366
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.34059632
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32137533
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.18575858
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.15708778
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11917598
19DROSHA_22980978_ChIP-Seq_HELA_Human2.09659474
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.03897645
21REST_21632747_ChIP-Seq_MESCs_Mouse2.02772396
22AR_21572438_ChIP-Seq_LNCaP_Human1.96610367
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95760174
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.95610639
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88723244
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78413543
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76693068
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73255909
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66589153
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.64023675
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63564959
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61263725
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56906537
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55481078
35SMAD4_21799915_ChIP-Seq_A2780_Human1.53302324
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50566144
37* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49295971
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49208644
39* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48097869
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.47920766
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47337562
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46018342
43* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42034383
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41371307
45P300_19829295_ChIP-Seq_ESCs_Human1.41289871
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40802464
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.35935000
48STAT3_23295773_ChIP-Seq_U87_Human1.31652525
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30373898
50GATA1_22025678_ChIP-Seq_K562_Human1.28481807
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28159490
52* CBX2_27304074_Chip-Seq_ESCs_Mouse1.27960683
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27289344
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27024555
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26989826
56KDM2B_26808549_Chip-Seq_K562_Human1.26319502
57ER_23166858_ChIP-Seq_MCF-7_Human1.23748785
58IGF1R_20145208_ChIP-Seq_DFB_Human1.23101928
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21702805
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20687739
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19841407
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17607954
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17347553
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16732002
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.14639438
66RNF2_27304074_Chip-Seq_NSC_Mouse1.13993365
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13861059
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.13423881
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12756247
70VDR_22108803_ChIP-Seq_LS180_Human1.12701035
71AHR_22903824_ChIP-Seq_MCF-7_Human1.12006215
72EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11105446
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.10847719
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09884475
75* TCF4_23295773_ChIP-Seq_U87_Human1.09814827
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09628135
77* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08308993
78TP53_16413492_ChIP-PET_HCT116_Human1.08134933
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07846963
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.07649818
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07236946
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07067677
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07056541
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06908213
85AR_25329375_ChIP-Seq_VCAP_Human1.05921938
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.05648934
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05434743
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04597764
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04275165
90* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03466605
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02559843
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02237531
93* ERG_21242973_ChIP-ChIP_JURKAT_Human1.02041877
94FUS_26573619_Chip-Seq_HEK293_Human1.00862028
95* RING1B_27294783_Chip-Seq_NPCs_Mouse1.00004452
96ZNF274_21170338_ChIP-Seq_K562_Hela0.99589256
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.98091298
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96803817
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96803817
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96780675
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96046964
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95872750
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95754848
104AR_19668381_ChIP-Seq_PC3_Human0.95733576
105* RUNX2_22187159_ChIP-Seq_PCA_Human0.94000990
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93639437
107ESR2_21235772_ChIP-Seq_MCF-7_Human0.93400242
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92466998
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.91497819
110* SMAD4_21741376_ChIP-Seq_EPCs_Human0.91159659
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90966313
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90911613
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90247227
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90247227
115TP53_18474530_ChIP-ChIP_U2OS_Human0.90242917
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.89688632
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88128875
118* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87946533
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.87655487
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86971085
121KDM2B_26808549_Chip-Seq_REH_Human0.86853281
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86807344
123DPY_21335234_ChIP-Seq_ESCs_Mouse0.84656287
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.84014009
125* CTCF_27219007_Chip-Seq_Bcells_Human0.83613444
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.83463530
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82767054
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82664330
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81622822
130* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80419616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.85412256
2MP0003880_abnormal_central_pattern4.82474341
3MP0004270_analgesia4.38606336
4MP0000920_abnormal_myelination3.55232165
5* MP0003635_abnormal_synaptic_transmissio3.27710036
6* MP0002272_abnormal_nervous_system3.00618377
7* MP0002064_seizures2.91655325
8* MP0009046_muscle_twitch2.87575617
9* MP0009745_abnormal_behavioral_response2.74740666
10MP0002734_abnormal_mechanical_nocicepti2.73044703
11* MP0001486_abnormal_startle_reflex2.67868157
12MP0003329_amyloid_beta_deposits2.64996867
13MP0001968_abnormal_touch/_nociception2.54609419
14MP0002063_abnormal_learning/memory/cond2.52229032
15MP0002572_abnormal_emotion/affect_behav2.27812439
16* MP0002735_abnormal_chemical_nociception2.26178310
17MP0005423_abnormal_somatic_nervous2.24890605
18MP0002736_abnormal_nociception_after2.13861380
19MP0003690_abnormal_glial_cell2.12178825
20MP0008569_lethality_at_weaning2.09664433
21MP0000778_abnormal_nervous_system2.07359583
22MP0004142_abnormal_muscle_tone2.05349280
23MP0001440_abnormal_grooming_behavior2.01826425
24* MP0002067_abnormal_sensory_capabilities2.01430715
25MP0001529_abnormal_vocalization2.01162493
26MP0004885_abnormal_endolymph2.00837274
27MP0004742_abnormal_vestibular_system1.92831893
28* MP0001970_abnormal_pain_threshold1.89125787
29MP0000955_abnormal_spinal_cord1.88641524
30* MP0002733_abnormal_thermal_nociception1.78173570
31MP0002229_neurodegeneration1.76436701
32MP0001485_abnormal_pinna_reflex1.74145355
33MP0005171_absent_coat_pigmentation1.73157061
34MP0002184_abnormal_innervation1.72153289
35* MP0003634_abnormal_glial_cell1.71408651
36MP0001501_abnormal_sleep_pattern1.68342406
37MP0005409_darkened_coat_color1.67659954
38MP0001905_abnormal_dopamine_level1.67000348
39MP0003787_abnormal_imprinting1.65314843
40MP0002882_abnormal_neuron_morphology1.61963213
41MP0003632_abnormal_nervous_system1.57987070
42MP0002822_catalepsy1.55955003
43MP0006276_abnormal_autonomic_nervous1.53471471
44MP0004858_abnormal_nervous_system1.52519761
45MP0004145_abnormal_muscle_electrophysio1.52245813
46* MP0002066_abnormal_motor_capabilities/c1.51921727
47MP0003950_abnormal_plasma_membrane1.50857820
48MP0003631_nervous_system_phenotype1.49451293
49MP0003633_abnormal_nervous_system1.48413130
50* MP0004924_abnormal_behavior1.39712871
51* MP0005386_behavior/neurological_phenoty1.39712871
52MP0004811_abnormal_neuron_physiology1.37847679
53MP0000604_amyloidosis1.29298548
54MP0003136_yellow_coat_color1.27546542
55MP0005167_abnormal_blood-brain_barrier1.26411267
56MP0003123_paternal_imprinting1.24450190
57MP0005410_abnormal_fertilization1.21360103
58* MP0002557_abnormal_social/conspecific_i1.20086049
59* MP0001963_abnormal_hearing_physiology1.19817218
60MP0002752_abnormal_somatic_nervous1.19733049
61MP0003122_maternal_imprinting1.18882113
62MP0001299_abnormal_eye_distance/1.15154018
63MP0005551_abnormal_eye_electrophysiolog1.12834589
64MP0004043_abnormal_pH_regulation1.10860157
65MP0009780_abnormal_chondrocyte_physiolo1.10857918
66MP0000747_muscle_weakness1.08031899
67MP0000751_myopathy1.01317854
68* MP0002152_abnormal_brain_morphology1.00720219
69MP0005646_abnormal_pituitary_gland0.98597064
70MP0001188_hyperpigmentation0.97637252
71MP0001502_abnormal_circadian_rhythm0.97521402
72MP0005623_abnormal_meninges_morphology0.96155187
73MP0003879_abnormal_hair_cell0.88900233
74MP0001177_atelectasis0.86740607
75MP0002638_abnormal_pupillary_reflex0.83937191
76MP0010386_abnormal_urinary_bladder0.83929635
77MP0000462_abnormal_digestive_system0.83764058
78MP0001346_abnormal_lacrimal_gland0.83348379
79MP0005645_abnormal_hypothalamus_physiol0.81012484
80MP0008260_abnormal_autophagy0.80917394
81MP0003075_altered_response_to0.80136907
82MP0001984_abnormal_olfaction0.79908455
83MP0008877_abnormal_DNA_methylation0.78527360
84MP0001986_abnormal_taste_sensitivity0.78305329
85MP0000026_abnormal_inner_ear0.78191880
86MP0008874_decreased_physiological_sensi0.74744717
87MP0003045_fibrosis0.73669139
88MP0003938_abnormal_ear_development0.70606678
89MP0002069_abnormal_eating/drinking_beha0.68497011
90MP0002909_abnormal_adrenal_gland0.68441323
91MP0004134_abnormal_chest_morphology0.65843960
92MP0000569_abnormal_digit_pigmentation0.65555580
93MP0000749_muscle_degeneration0.64240517
94* MP0004085_abnormal_heartbeat0.63905681
95MP0004130_abnormal_muscle_cell0.62401940
96MP0005195_abnormal_posterior_eye0.60877543
97MP0002751_abnormal_autonomic_nervous0.60253559
98MP0001943_abnormal_respiration0.59380484
99MP0002090_abnormal_vision0.58453449
100MP0000579_abnormal_nail_morphology0.58099027
101MP0004036_abnormal_muscle_relaxation0.57827300
102MP0001664_abnormal_digestion0.56348806
103* MP0010768_mortality/aging0.55941629
104MP0010678_abnormal_skin_adnexa0.55888839
105* MP0002082_postnatal_lethality0.54732992
106MP0008872_abnormal_physiological_respon0.53901710
107MP0004381_abnormal_hair_follicle0.53158741
108MP0000631_abnormal_neuroendocrine_gland0.52840127
109* MP0003956_abnormal_body_size0.51600709
110* MP0003861_abnormal_nervous_system0.51544637
111MP0005535_abnormal_body_temperature0.51356826
112MP0001765_abnormal_ion_homeostasis0.51184933
113MP0002295_abnormal_pulmonary_circulatio0.50224428
114MP0004215_abnormal_myocardial_fiber0.50200120
115MP0004510_myositis0.50151715
116* MP0010769_abnormal_survival0.49536559
117* MP0003137_abnormal_impulse_conducting0.48822762
118MP0004484_altered_response_of0.46776180
119* MP0010770_preweaning_lethality0.46559249
120MP0000639_abnormal_adrenal_gland0.44285862
121MP0002873_normal_phenotype0.42280716
122MP0003283_abnormal_digestive_organ0.41077785
123MP0003172_abnormal_lysosome_physiology0.40469048
124MP0002169_no_abnormal_phenotype0.40459765

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.72142157
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.21121240
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.21121240
4Action tremor (HP:0002345)4.58030569
5Neurofibrillary tangles (HP:0002185)4.55112431
6Abnormality of the corticospinal tract (HP:0002492)4.46731668
7Supranuclear gaze palsy (HP:0000605)4.40343291
8* Myokymia (HP:0002411)4.37583148
9Insidious onset (HP:0003587)4.15031804
10Termporal pattern (HP:0011008)4.15031804
11Papilledema (HP:0001085)4.10342159
12Scanning speech (HP:0002168)4.06603947
13Peripheral hypomyelination (HP:0007182)4.03534459
14Focal seizures (HP:0007359)3.98858411
15Onion bulb formation (HP:0003383)3.93318019
16Atonic seizures (HP:0010819)3.86089324
17Ulnar claw (HP:0001178)3.85899196
18Dysmetria (HP:0001310)3.84216342
19Hemiplegia (HP:0002301)3.82937576
20Obstructive sleep apnea (HP:0002870)3.77928426
21Ankle clonus (HP:0011448)3.55367623
22Cerebral inclusion bodies (HP:0100314)3.49899181
23Epileptic encephalopathy (HP:0200134)3.43255015
24Status epilepticus (HP:0002133)3.40647177
25Sensory axonal neuropathy (HP:0003390)3.38413537
26Intention tremor (HP:0002080)3.35665054
27Annular pancreas (HP:0001734)3.35532371
28Progressive cerebellar ataxia (HP:0002073)3.35043318
29Segmental peripheral demyelination/remyelination (HP:0003481)3.31650969
30* Spastic gait (HP:0002064)3.23780918
31Tetraplegia (HP:0002445)3.19253376
32Gaze-evoked nystagmus (HP:0000640)3.14863293
33Epileptiform EEG discharges (HP:0011182)3.10660384
34Parakeratosis (HP:0001036)3.04299163
35Focal dystonia (HP:0004373)3.03142844
36Impaired smooth pursuit (HP:0007772)3.02385909
37Febrile seizures (HP:0002373)2.99222548
38Limb dystonia (HP:0002451)2.99152852
39Pheochromocytoma (HP:0002666)2.98094238
40Craniofacial dystonia (HP:0012179)2.89728862
41Bradykinesia (HP:0002067)2.87987322
42Dialeptic seizures (HP:0011146)2.87519660
43Genetic anticipation (HP:0003743)2.83478529
44Dysdiadochokinesis (HP:0002075)2.82045989
45Hammertoe (HP:0001765)2.80973196
46Absence seizures (HP:0002121)2.78815459
47Foot dorsiflexor weakness (HP:0009027)2.76803566
48Broad-based gait (HP:0002136)2.76796141
49Dysmetric saccades (HP:0000641)2.72820774
50Slow saccadic eye movements (HP:0000514)2.71952394
51Truncal ataxia (HP:0002078)2.68320654
52Decreased motor nerve conduction velocity (HP:0003431)2.68152545
53Visual hallucinations (HP:0002367)2.66638380
54Urinary urgency (HP:0000012)2.65374151
55Retinal dysplasia (HP:0007973)2.64441647
56Abnormality of ocular smooth pursuit (HP:0000617)2.63352645
57EEG with generalized epileptiform discharges (HP:0011198)2.63272730
58Neuroendocrine neoplasm (HP:0100634)2.63209672
59Sleep apnea (HP:0010535)2.62996968
60Generalized tonic-clonic seizures (HP:0002069)2.57778063
61Akinesia (HP:0002304)2.55636370
62Steppage gait (HP:0003376)2.55360586
63Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.52436670
64Lower limb muscle weakness (HP:0007340)2.52146786
65Abnormal social behavior (HP:0012433)2.50694325
66Impaired social interactions (HP:0000735)2.50694325
67Abnormality of the foot musculature (HP:0001436)2.49803089
68Abnormal auditory evoked potentials (HP:0006958)2.46034545
69Hypsarrhythmia (HP:0002521)2.42911401
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.42277118
71Urinary bladder sphincter dysfunction (HP:0002839)2.41834202
72Cerebral hypomyelination (HP:0006808)2.39356617
73Abnormality of the lower motor neuron (HP:0002366)2.36243457
74Amblyopia (HP:0000646)2.35078135
75Impaired vibration sensation in the lower limbs (HP:0002166)2.34214334
76Rigidity (HP:0002063)2.32226007
77Progressive inability to walk (HP:0002505)2.30924501
78Distal sensory impairment (HP:0002936)2.29559543
79Impaired vibratory sensation (HP:0002495)2.29477761
80Stereotypic behavior (HP:0000733)2.28624918
81Thickened helices (HP:0000391)2.24659661
82Hyperventilation (HP:0002883)2.22668321
83Choreoathetosis (HP:0001266)2.21632878
84Alacrima (HP:0000522)2.20969150
85Anxiety (HP:0000739)2.20038646
86Generalized myoclonic seizures (HP:0002123)2.18558945
87Increased circulating renin level (HP:0000848)2.17814202
88Birth length less than 3rd percentile (HP:0003561)2.17198180
89Cerebral hemorrhage (HP:0001342)2.13718271
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13358095
91Insomnia (HP:0100785)2.10997593
92Ventricular fibrillation (HP:0001663)2.10831059
93Hemiparesis (HP:0001269)2.10054620
94Clumsiness (HP:0002312)2.09939005
95Postural instability (HP:0002172)2.09435409
96Abnormality of saccadic eye movements (HP:0000570)2.09311760
97Bundle branch block (HP:0011710)2.08660722
98Clonus (HP:0002169)2.08564244
99Megalencephaly (HP:0001355)2.06844155
100Aplasia involving bones of the upper limbs (HP:0009823)2.04149297
101Aplasia of the phalanges of the hand (HP:0009802)2.04149297
102Aplasia involving bones of the extremities (HP:0009825)2.04149297
103Abnormal eating behavior (HP:0100738)2.03405791
104Incomplete penetrance (HP:0003829)2.02552953
105Depression (HP:0000716)2.01938056
106Apathy (HP:0000741)2.01220159
107CNS hypomyelination (HP:0003429)1.99702234
108Rapidly progressive (HP:0003678)1.95198734
109Morphological abnormality of the pyramidal tract (HP:0002062)1.94820243
110Leukodystrophy (HP:0002415)1.94343867
111Lower limb asymmetry (HP:0100559)1.93992261
112Autoamputation (HP:0001218)1.93988325
113Spastic tetraparesis (HP:0001285)1.92204651
114Synostosis involving the elbow (HP:0003938)1.89984564
115Humeroradial synostosis (HP:0003041)1.89984564
116Hypomagnesemia (HP:0002917)1.86378999
117Delusions (HP:0000746)1.85569531
118Bronchomalacia (HP:0002780)1.85507798
119Diplopia (HP:0000651)1.85013114
120Abnormality of binocular vision (HP:0011514)1.85013114
121Absent speech (HP:0001344)1.84898895
122Gait ataxia (HP:0002066)1.80718245
123Split foot (HP:0001839)1.80142086
124Memory impairment (HP:0002354)1.79221080
125Neuronal loss in central nervous system (HP:0002529)1.78606493
126Slow progression (HP:0003677)1.76012189
127Diminished motivation (HP:0000745)1.75574938
128Heart block (HP:0012722)1.75443354
129Poor speech (HP:0002465)1.73868703
130Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71865473
131Anteriorly placed anus (HP:0001545)1.71776512
132Excessive salivation (HP:0003781)1.71133329
133Drooling (HP:0002307)1.71133329
134Torticollis (HP:0000473)1.71026869
135Fetal akinesia sequence (HP:0001989)1.70830428
136Absent septum pellucidum (HP:0001331)1.70678579
137Poor eye contact (HP:0000817)1.70224957
138Mutism (HP:0002300)1.69586944
139Paraplegia (HP:0010550)1.69298355
140Prolonged QT interval (HP:0001657)1.69152144
141Spastic paraplegia (HP:0001258)1.69086092
142Protruding tongue (HP:0010808)1.67652655
143Spinal canal stenosis (HP:0003416)1.61285990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.72430534
2OXSR13.40073303
3NTRK33.33859204
4EPHA43.12227187
5CDK192.45886255
6CASK2.30025870
7WNK12.28910651
8MAP3K92.23418890
9NTRK12.21226413
10WNK42.12180055
11EPHB12.04715655
12LATS21.94089354
13MINK11.91738936
14PNCK1.87828184
15PAK61.84218929
16MAP3K41.81894019
17TNIK1.80884623
18PRPF4B1.80732290
19MARK11.70142133
20BCR1.67647014
21PKN11.65616545
22SIK21.64815690
23RIPK11.62990261
24LIMK11.50064393
25DAPK11.48898986
26CAMK2B1.48615965
27MAP2K71.46738442
28UHMK11.46206608
29SGK4941.40822065
30SGK2231.40822065
31KSR21.40449058
32MAPKAPK51.40367062
33CDK51.34538443
34NEK61.30225636
35NTRK21.26933165
36ROCK21.23070832
37STK381.16446983
38PHKG11.16166802
39PHKG21.16166802
40FGFR21.14270186
41CAMK2A1.12937766
42MARK21.12895660
43CAMK2D1.11695471
44MUSK1.08035002
45ARAF1.07676787
46FGR1.07005831
47CSNK1G21.06874704
48MAPK131.05067303
49SGK21.04977148
50CAMK2G1.04932726
51ALK1.02361065
52MET0.99817344
53MAP2K40.99392292
54CSNK1G30.99255913
55CAMK40.96828024
56CSNK1A1L0.96374686
57PDPK10.94418634
58LMTK20.93167985
59CDK140.91376019
60PAK30.90365858
61CAMKK20.90135382
62MAP3K130.88096506
63CDK150.86203007
64DAPK20.85144836
65CDK180.84684606
66SGK30.82411414
67PRKCG0.81750896
68FES0.80709055
69MAP3K20.76536439
70TESK20.76127152
71TYRO30.75876780
72CDK11A0.74925357
73MAPK120.74131041
74ICK0.73568693
75PRKD30.71936188
76GRK50.70968600
77PRKCH0.69469502
78CAMKK10.69175822
79PDK10.68008474
80CSNK1G10.67280909
81PRKCE0.66412418
82RPS6KA30.64695527
83PBK0.64438197
84PLK20.64367250
85KSR10.63916682
86RIPK40.63415698
87PTK2B0.62560287
88GRK70.62203093
89STK110.62045799
90CAMK10.60965409
91ACVR1B0.60413040
92CLK10.57822552
93PRKCQ0.57254600
94FYN0.55673771
95CAMK1G0.53033850
96MAP3K120.51580303
97RET0.51491053
98PRKD10.50847114
99DYRK1A0.50805856
100PINK10.48972207
101CSNK1A10.48110589
102SGK10.48028413
103PRKG10.47624987
104BRSK10.47353862
105BRAF0.47218730
106PRKACB0.46802564
107ERBB40.46211002
108BMPR20.43317290
109MAP2K10.42475973
110CAMK1D0.42448720
111MAP2K60.41873383
112RAF10.41329166
113MAPK100.40868856
114CSNK1E0.39849881
115PRKCZ0.39481409
116TNK20.39412592
117TRPM70.37473850
118PRKACA0.36805960
119DYRK20.36344782
120DAPK30.35586416
121PRKCA0.32843900
122MAP3K110.31130574
123MAP3K10.29164498
124PRKCB0.28737009
125BMPR1B0.26831658
126CCNB10.26063693
127PRKG20.25835875
128CSNK1D0.25171243
129GSK3B0.24695711

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.90525931
2Glutamatergic synapse_Homo sapiens_hsa047242.48348753
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43659575
4GABAergic synapse_Homo sapiens_hsa047272.39852044
5Synaptic vesicle cycle_Homo sapiens_hsa047212.39255486
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37013786
7Circadian entrainment_Homo sapiens_hsa047132.24590773
8Morphine addiction_Homo sapiens_hsa050322.19607062
9Fatty acid elongation_Homo sapiens_hsa000622.06773597
10Olfactory transduction_Homo sapiens_hsa047402.05261104
11Long-term potentiation_Homo sapiens_hsa047202.03438592
12Salivary secretion_Homo sapiens_hsa049701.92993892
13Steroid biosynthesis_Homo sapiens_hsa001001.91199069
14Amphetamine addiction_Homo sapiens_hsa050311.83582942
15Dopaminergic synapse_Homo sapiens_hsa047281.80955943
16Serotonergic synapse_Homo sapiens_hsa047261.79693366
17Axon guidance_Homo sapiens_hsa043601.74714133
18Long-term depression_Homo sapiens_hsa047301.72023530
19Gastric acid secretion_Homo sapiens_hsa049711.67381310
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67269564
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65733745
22Taste transduction_Homo sapiens_hsa047421.62997187
23Cholinergic synapse_Homo sapiens_hsa047251.60909269
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58452875
25Ether lipid metabolism_Homo sapiens_hsa005651.56217596
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42819192
27Insulin secretion_Homo sapiens_hsa049111.39738864
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37828269
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37538020
30Renin secretion_Homo sapiens_hsa049241.36338411
31Cocaine addiction_Homo sapiens_hsa050301.35140551
32Calcium signaling pathway_Homo sapiens_hsa040201.32112431
33Collecting duct acid secretion_Homo sapiens_hsa049661.28615323
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27015159
35Oxytocin signaling pathway_Homo sapiens_hsa049211.24626721
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19101314
37Cardiac muscle contraction_Homo sapiens_hsa042601.18343745
38Oxidative phosphorylation_Homo sapiens_hsa001901.18196116
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16081955
40Nitrogen metabolism_Homo sapiens_hsa009101.13416724
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12046887
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10972388
43cAMP signaling pathway_Homo sapiens_hsa040241.10918235
44Gap junction_Homo sapiens_hsa045401.08725165
45Alzheimers disease_Homo sapiens_hsa050101.06187293
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.06027474
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04111914
48ErbB signaling pathway_Homo sapiens_hsa040121.04094015
49Dorso-ventral axis formation_Homo sapiens_hsa043201.03743730
50Vibrio cholerae infection_Homo sapiens_hsa051101.03245400
51GnRH signaling pathway_Homo sapiens_hsa049121.01290295
52Sphingolipid metabolism_Homo sapiens_hsa006000.99246171
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99053805
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97481981
55Pancreatic secretion_Homo sapiens_hsa049720.94715057
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93412976
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.92922050
58Phototransduction_Homo sapiens_hsa047440.88398822
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.86642104
60Parkinsons disease_Homo sapiens_hsa050120.83904702
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81485016
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78563479
63Melanogenesis_Homo sapiens_hsa049160.78469343
64Ras signaling pathway_Homo sapiens_hsa040140.78241726
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72877340
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72819814
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72292182
68Endocytosis_Homo sapiens_hsa041440.71641432
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70644964
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67997031
71Estrogen signaling pathway_Homo sapiens_hsa049150.67479972
72Renal cell carcinoma_Homo sapiens_hsa052110.67135165
73Sulfur metabolism_Homo sapiens_hsa009200.65967842
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65780689
75VEGF signaling pathway_Homo sapiens_hsa043700.65710683
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.65647009
77Choline metabolism in cancer_Homo sapiens_hsa052310.64454658
78MAPK signaling pathway_Homo sapiens_hsa040100.64255812
79Tight junction_Homo sapiens_hsa045300.64113424
80Vitamin B6 metabolism_Homo sapiens_hsa007500.61921675
81Thyroid hormone synthesis_Homo sapiens_hsa049180.61253167
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60374388
83Butanoate metabolism_Homo sapiens_hsa006500.60340109
84Dilated cardiomyopathy_Homo sapiens_hsa054140.59886067
85Type II diabetes mellitus_Homo sapiens_hsa049300.59205270
86Ovarian steroidogenesis_Homo sapiens_hsa049130.59200994
87Circadian rhythm_Homo sapiens_hsa047100.58960393
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.57290906
89Arginine biosynthesis_Homo sapiens_hsa002200.56337379
90Glucagon signaling pathway_Homo sapiens_hsa049220.55621183
91Inositol phosphate metabolism_Homo sapiens_hsa005620.54620298
92Fatty acid biosynthesis_Homo sapiens_hsa000610.52467835
93Prion diseases_Homo sapiens_hsa050200.51756783
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50411003
95Glioma_Homo sapiens_hsa052140.50366221
96Mineral absorption_Homo sapiens_hsa049780.48307840
97Rap1 signaling pathway_Homo sapiens_hsa040150.47665032
98Linoleic acid metabolism_Homo sapiens_hsa005910.47374586
99Oocyte meiosis_Homo sapiens_hsa041140.42962213
100Bile secretion_Homo sapiens_hsa049760.41594599
101Histidine metabolism_Homo sapiens_hsa003400.41068572
102Arginine and proline metabolism_Homo sapiens_hsa003300.40420676
103Wnt signaling pathway_Homo sapiens_hsa043100.40086043
104Rheumatoid arthritis_Homo sapiens_hsa053230.39264977
105Huntingtons disease_Homo sapiens_hsa050160.39179654
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38996052
107Hedgehog signaling pathway_Homo sapiens_hsa043400.38740052
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38715013
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37558952
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36017542
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35414877
112Alcoholism_Homo sapiens_hsa050340.34478541
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34182194
114mTOR signaling pathway_Homo sapiens_hsa041500.31338205
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27088222
116ABC transporters_Homo sapiens_hsa020100.26730910
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24721515
118beta-Alanine metabolism_Homo sapiens_hsa004100.22960299
119Insulin signaling pathway_Homo sapiens_hsa049100.21359952
120HIF-1 signaling pathway_Homo sapiens_hsa040660.19627892
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17222039
122Hippo signaling pathway_Homo sapiens_hsa043900.17200376
123AMPK signaling pathway_Homo sapiens_hsa041520.16738474

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