KCNA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of neurological system process (GO:0031646)8.59430632
2auditory receptor cell differentiation (GO:0042491)6.77352132
3sulfate transmembrane transport (GO:1902358)6.68858455
4negative regulation of DNA recombination (GO:0045910)6.11203956
5protein localization to cilium (GO:0061512)5.76789410
6sulfate transport (GO:0008272)5.34026986
7regulation of transmission of nerve impulse (GO:0051969)5.25271725
8pentose metabolic process (GO:0019321)5.00109159
9regulation of double-strand break repair via homologous recombination (GO:0010569)4.96311682
10synaptic vesicle exocytosis (GO:0016079)4.93562905
11platelet dense granule organization (GO:0060155)4.83594529
12positive regulation of neurotransmitter secretion (GO:0001956)4.78491003
13sensory perception of sound (GO:0007605)4.71289350
14sensory perception of mechanical stimulus (GO:0050954)4.66579146
15carnitine shuttle (GO:0006853)4.39781028
16righting reflex (GO:0060013)4.39363268
17diterpenoid biosynthetic process (GO:0016102)4.35642673
18adult feeding behavior (GO:0008343)4.33494467
19positive regulation of catecholamine secretion (GO:0033605)4.29494127
20inner ear receptor cell differentiation (GO:0060113)4.22625451
21respiratory chain complex IV assembly (GO:0008535)4.22489642
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.96933773
23cardiac muscle cell proliferation (GO:0060038)3.92423532
24glycogen catabolic process (GO:0005980)3.80790967
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.80434346
26regulation of meiosis I (GO:0060631)3.77858068
27hair cell differentiation (GO:0035315)3.77209829
28neuron remodeling (GO:0016322)3.73713256
29positive regulation of neurotransmitter transport (GO:0051590)3.73607482
30modulation by virus of host process (GO:0019054)3.69555274
31negative regulation of appetite (GO:0032099)3.69065874
32negative regulation of response to food (GO:0032096)3.69065874
33inner ear morphogenesis (GO:0042472)3.63928191
34fatty acid transmembrane transport (GO:1902001)3.60181841
35glucan catabolic process (GO:0009251)3.55392655
36glomerular filtration (GO:0003094)3.54302716
37negative regulation of bone remodeling (GO:0046851)3.53704848
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.53465176
39negative regulation of bone resorption (GO:0045779)3.51050252
40positive regulation of gastrulation (GO:2000543)3.48422780
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.46373397
42glutamate secretion (GO:0014047)3.46213940
43ADP metabolic process (GO:0046031)3.45569910
44mechanoreceptor differentiation (GO:0042490)3.41813546
45genitalia morphogenesis (GO:0035112)3.40554835
46type B pancreatic cell proliferation (GO:0044342)3.35143153
47regulation of hippo signaling (GO:0035330)3.31790809
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30068614
49terpenoid biosynthetic process (GO:0016114)3.27870030
50striated muscle cell proliferation (GO:0014855)3.26614639
51alpha-linolenic acid metabolic process (GO:0036109)3.26377227
52cytochrome complex assembly (GO:0017004)3.22348922
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.18034296
54cellular polysaccharide catabolic process (GO:0044247)3.16679193
55muscle cell proliferation (GO:0033002)3.15573995
56renal filtration (GO:0097205)3.13633933
57regulation of catecholamine secretion (GO:0050433)3.09615811
58reflex (GO:0060004)3.09049348
59carnitine transmembrane transport (GO:1902603)3.00623303
60positive regulation of oligodendrocyte differentiation (GO:0048714)2.99685483
61negative regulation of tissue remodeling (GO:0034104)2.99346718
62protein localization to synapse (GO:0035418)2.97855859
63cell aggregation (GO:0098743)2.96209392
64cartilage condensation (GO:0001502)2.96209392
65polysaccharide catabolic process (GO:0000272)2.96083297
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.93254103
67dopamine transport (GO:0015872)2.91086205
68tRNA methylation (GO:0030488)2.90742455
69secretory granule organization (GO:0033363)2.86209059
70positive regulation of meiosis (GO:0045836)2.85981987
71anterograde synaptic vesicle transport (GO:0048490)2.85092414
72transmission of nerve impulse (GO:0019226)2.82099444
73regulation of non-canonical Wnt signaling pathway (GO:2000050)2.80400233
74negative regulation of sodium ion transport (GO:0010766)2.80388880
75regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.79711169
76positive regulation of B cell differentiation (GO:0045579)2.78375449
77modulation by symbiont of host cellular process (GO:0044068)2.75542550
78short-term memory (GO:0007614)2.73682325
79carnitine transport (GO:0015879)2.73378009
80amino-acid betaine transport (GO:0015838)2.73378009
81regulation of feeding behavior (GO:0060259)2.72063855
82regulation of dopamine secretion (GO:0014059)2.71984577
83non-canonical Wnt signaling pathway (GO:0035567)2.70893232
84catecholamine transport (GO:0051937)2.69558782
85calcium-mediated signaling using intracellular calcium source (GO:0035584)2.66689349
86biotin metabolic process (GO:0006768)2.66525371
87cerebellar Purkinje cell differentiation (GO:0021702)2.66403406
88ribonucleoside diphosphate metabolic process (GO:0009185)2.65680780
89outer ear morphogenesis (GO:0042473)2.65451619
90glutamate receptor signaling pathway (GO:0007215)2.62384250
91response to gravity (GO:0009629)2.60879300
92retinal metabolic process (GO:0042574)2.59960130
93positive regulation of synapse assembly (GO:0051965)2.59390811
94positive regulation of meiotic cell cycle (GO:0051446)2.58991829
95cellular carbohydrate catabolic process (GO:0044275)2.58934945
96calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.56516171
97Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55408128
98positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52243213
99postsynaptic membrane organization (GO:0001941)2.51949311
100negative regulation of DNA repair (GO:0045738)10.7794347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.52962288
2EZH2_22144423_ChIP-Seq_EOC_Human3.31458993
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08063459
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05161993
5SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.00682169
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00093707
7GBX2_23144817_ChIP-Seq_PC3_Human2.99334805
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.89377403
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78192276
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78192276
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63320185
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44258050
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36524951
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.27860149
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25182078
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22104523
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.15405270
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.09519099
19TAF15_26573619_Chip-Seq_HEK293_Human2.07030711
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05570878
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02474633
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.00998049
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.99395061
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.98799601
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86839914
26REST_21632747_ChIP-Seq_MESCs_Mouse1.84141240
27WT1_19549856_ChIP-ChIP_CCG9911_Human1.78039768
28BCAT_22108803_ChIP-Seq_LS180_Human1.71107580
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69890926
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69165110
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66858475
32IGF1R_20145208_ChIP-Seq_DFB_Human1.64931516
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62923609
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.60934638
35TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60610918
36POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60610918
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54796836
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53567661
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.52382560
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51246212
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.44702887
42P300_19829295_ChIP-Seq_ESCs_Human1.42874895
43SMAD4_21799915_ChIP-Seq_A2780_Human1.40196903
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37278206
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36665142
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.36216106
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35397361
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35289300
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33845957
50VDR_24787735_ChIP-Seq_THP-1_Human1.33706289
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.29867988
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28858525
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28656683
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27970840
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27192770
56DROSHA_22980978_ChIP-Seq_HELA_Human1.26379739
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25004882
58JUN_21703547_ChIP-Seq_K562_Human1.23202377
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22587918
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.21675918
61AR_21572438_ChIP-Seq_LNCaP_Human1.20328551
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.20245742
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17745887
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16964942
65EWS_26573619_Chip-Seq_HEK293_Human1.16477012
66TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16443175
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15426154
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14899967
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14899967
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14899967
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.14779814
72TP53_20018659_ChIP-ChIP_R1E_Mouse1.14556072
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14542476
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12756246
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11783706
76FUS_26573619_Chip-Seq_HEK293_Human1.11547175
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.10568375
78AHR_22903824_ChIP-Seq_MCF-7_Human1.09396872
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06773645
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06695702
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.05933355
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05180896
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05060727
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.04103287
85* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02600111
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01002319
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00904171
88ER_23166858_ChIP-Seq_MCF-7_Human1.00349404
89RUNX2_22187159_ChIP-Seq_PCA_Human0.99981714
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.97754668
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97434177
92TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97334652
93TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96075770
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.95425354
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94536638
96CTCF_27219007_Chip-Seq_Bcells_Human0.93835245
97RARB_27405468_Chip-Seq_BRAIN_Mouse0.93759692
98CJUN_26792858_Chip-Seq_BT549_Human0.93299129
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90982234
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90601161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001485_abnormal_pinna_reflex5.57486233
2MP0005377_hearing/vestibular/ear_phenot5.06799669
3MP0003878_abnormal_ear_physiology5.06799669
4MP0000026_abnormal_inner_ear3.61505488
5MP0001963_abnormal_hearing_physiology3.45323242
6MP0006276_abnormal_autonomic_nervous2.96203045
7MP0001486_abnormal_startle_reflex2.83857543
8MP0010030_abnormal_orbit_morphology2.57731831
9MP0001348_abnormal_lacrimal_gland2.57712616
10MP0005423_abnormal_somatic_nervous2.23141466
11MP0000751_myopathy2.16350432
12MP0004859_abnormal_synaptic_plasticity2.10985141
13MP0004742_abnormal_vestibular_system2.08149143
14MP0002272_abnormal_nervous_system2.01359604
15MP0003879_abnormal_hair_cell10.4292094
16MP0005248_abnormal_Harderian_gland1.97636017
17MP0003880_abnormal_central_pattern1.84171346
18MP0003635_abnormal_synaptic_transmissio1.79444290
19MP0004270_analgesia1.77683088
20MP0005187_abnormal_penis_morphology1.62809687
21MP0003959_abnormal_lean_body1.55689557
22MP0004233_abnormal_muscle_weight1.49826339
23MP0004885_abnormal_endolymph1.48438158
24MP0004130_abnormal_muscle_cell1.48164525
25MP0002009_preneoplasia1.38325052
26MP0005623_abnormal_meninges_morphology1.33461512
27MP0003646_muscle_fatigue1.33408699
28MP0001502_abnormal_circadian_rhythm1.32023890
29MP0004272_abnormal_basement_membrane1.29917727
30MP0002063_abnormal_learning/memory/cond1.29572377
31MP0002332_abnormal_exercise_endurance1.25066323
32MP0002064_seizures1.20062552
33MP0003119_abnormal_digestive_system1.15849930
34MP0003191_abnormal_cellular_cholesterol1.15420760
35MP0002184_abnormal_innervation1.13373215
36MP0009745_abnormal_behavioral_response1.13195547
37MP0000049_abnormal_middle_ear1.12081307
38MP0005448_abnormal_energy_balance1.08214096
39MP0000639_abnormal_adrenal_gland1.07884122
40MP0002229_neurodegeneration1.07390311
41MP0002102_abnormal_ear_morphology1.04075884
42MP0003938_abnormal_ear_development1.03786108
43MP0009780_abnormal_chondrocyte_physiolo1.03685874
44MP0002752_abnormal_somatic_nervous1.02130103
45MP0005535_abnormal_body_temperature1.00078501
46MP0003942_abnormal_urinary_system0.97856678
47MP0001346_abnormal_lacrimal_gland0.95357868
48MP0002233_abnormal_nose_morphology0.93823024
49MP0002572_abnormal_emotion/affect_behav0.91889098
50MP0004145_abnormal_muscle_electrophysio0.88399009
51MP0002882_abnormal_neuron_morphology0.85970594
52MP0002971_abnormal_brown_adipose0.84570402
53MP0009053_abnormal_anal_canal0.83119797
54MP0003122_maternal_imprinting0.81817810
55MP0002933_joint_inflammation0.81210403
56MP0009046_muscle_twitch0.76813951
57MP0002067_abnormal_sensory_capabilities0.74908980
58MP0005167_abnormal_blood-brain_barrier0.73388067
59MP0000778_abnormal_nervous_system0.72261124
60MP0003941_abnormal_skin_development0.71050443
61MP0004381_abnormal_hair_follicle0.63577410
62MP0000955_abnormal_spinal_cord0.61191696
63MP0002066_abnormal_motor_capabilities/c0.61121600
64MP0003948_abnormal_gas_homeostasis0.59992049
65MP0001905_abnormal_dopamine_level0.59758966
66MP0004484_altered_response_of0.59582983
67MP0002932_abnormal_joint_morphology0.58995267
68MP0005452_abnormal_adipose_tissue0.58559760
69MP0008874_decreased_physiological_sensi0.58126447
70MP0002733_abnormal_thermal_nociception0.57122004
71MP0001661_extended_life_span0.56967219
72MP0002282_abnormal_trachea_morphology0.55494897
73MP0001943_abnormal_respiration0.50352071
74MP0003633_abnormal_nervous_system0.50078758
75MP0001968_abnormal_touch/_nociception0.49537553
76MP0003638_abnormal_response/metabolism_0.48728241
77MP0001440_abnormal_grooming_behavior0.48567718
78MP0002909_abnormal_adrenal_gland0.48199974
79MP0000534_abnormal_ureter_morphology0.47131044
80MP0002114_abnormal_axial_skeleton0.46433068
81MP0004142_abnormal_muscle_tone0.43799799
82MP0000631_abnormal_neuroendocrine_gland0.42480641
83MP0010329_abnormal_lipoprotein_level0.42064341
84MP0009384_cardiac_valve_regurgitation0.42030748
85MP0003631_nervous_system_phenotype0.41801912
86MP0002069_abnormal_eating/drinking_beha0.40759084
87MP0001970_abnormal_pain_threshold0.40634897
88MP0002751_abnormal_autonomic_nervous0.40573192
89MP0002116_abnormal_craniofacial_bone0.40569726
90MP0002734_abnormal_mechanical_nocicepti0.40427517
91MP0005197_abnormal_uvea_morphology0.40065748
92MP0002638_abnormal_pupillary_reflex0.38869407
93MP0005646_abnormal_pituitary_gland0.38641720
94MP0005551_abnormal_eye_electrophysiolog0.38598280
95MP0001501_abnormal_sleep_pattern0.37619617
96MP0003195_calcinosis0.37556941
97MP0005083_abnormal_biliary_tract0.37003083
98MP0002152_abnormal_brain_morphology0.36663500
99MP0002837_dystrophic_cardiac_calcinosis0.36365901
100MP0002111_abnormal_tail_morphology0.35704675

Predicted human phenotypes

RankGene SetZ-score
1Rectal prolapse (HP:0002035)5.42073708
2Short middle phalanx of the 5th finger (HP:0004220)5.39678597
3Epiphyseal dysplasia (HP:0002656)5.32082867
4Atonic seizures (HP:0010819)4.88492455
5Urinary bladder sphincter dysfunction (HP:0002839)4.29855406
6Ankyloglossia (HP:0010296)4.09544152
7Increased number of teeth (HP:0011069)4.08240323
8Mesomelia (HP:0003027)4.07813181
9Vitreoretinal degeneration (HP:0000655)3.95667342
10Severe Myopia (HP:0011003)3.95360783
11Thoracolumbar scoliosis (HP:0002944)3.78806762
12Rib fusion (HP:0000902)3.52137226
13Abnormality of the right ventricle (HP:0001707)3.48948715
14Abnormal auditory evoked potentials (HP:0006958)3.40410536
15Cutaneous finger syndactyly (HP:0010554)3.38077210
16Abnormality of the tricuspid valve (HP:0001702)3.37495204
17Renal duplication (HP:0000075)3.35121913
18Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.28536449
19Bifid tongue (HP:0010297)3.20318850
20Febrile seizures (HP:0002373)3.17221522
21Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.16934440
22Thyroid-stimulating hormone excess (HP:0002925)3.14466536
23Hepatocellular necrosis (HP:0001404)3.14436560
24Aplasia/Hypoplasia of the sacrum (HP:0008517)3.11463460
25Epileptic encephalopathy (HP:0200134)3.11250848
26Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.04776221
27Abnormality of oral frenula (HP:0000190)3.03518919
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02923338
29Progressive cerebellar ataxia (HP:0002073)2.99034955
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.97917941
31Synostosis of carpal bones (HP:0005048)2.97674498
32Impaired platelet aggregation (HP:0003540)2.97233416
33Abnormal platelet function (HP:0011869)2.97233416
34Myokymia (HP:0002411)2.96976996
35Absence seizures (HP:0002121)2.95553955
36Focal motor seizures (HP:0011153)2.88018075
37Enlarged epiphyses (HP:0010580)2.86528705
38Hypoplastic labia majora (HP:0000059)2.81976918
39Action tremor (HP:0002345)2.79983519
40Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.74566969
41Abnormality of the nasal septum (HP:0000419)2.73943585
42Abnormality of the distal phalanges of the toes (HP:0010182)2.73216227
43Irregular epiphyses (HP:0010582)2.72315094
44Hypercholesterolemia (HP:0003124)2.70237747
45Symphalangism affecting the phalanges of the hand (HP:0009773)2.68552315
46Abnormality of the phalanges of the 5th finger (HP:0004213)2.68477353
47Cutaneous syndactyly (HP:0012725)2.67801191
48Abnormality of the lumbar spine (HP:0100712)2.64669962
49Abnormality of the labia majora (HP:0012881)2.64015502
50Missing ribs (HP:0000921)2.62699856
51Mixed hearing impairment (HP:0000410)2.60246170
52Mild short stature (HP:0003502)2.59893043
53Tubular atrophy (HP:0000092)2.56406211
54Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.53746352
55Sensorimotor neuropathy (HP:0007141)2.53510175
56Lip pit (HP:0100267)2.51934263
57Short 5th finger (HP:0009237)2.50595028
58Tented upper lip vermilion (HP:0010804)2.46673879
59Dialeptic seizures (HP:0011146)2.45719511
60Labial hypoplasia (HP:0000066)2.44271542
61Abnormality of the vitreous humor (HP:0004327)2.42668162
62Hypoplastic ischia (HP:0003175)2.41342241
63Albinism (HP:0001022)2.36024506
64Truncal ataxia (HP:0002078)2.35260043
65Long palpebral fissure (HP:0000637)2.34642018
66Morphological abnormality of the middle ear (HP:0008609)2.28244635
67Dysmetric saccades (HP:0000641)2.26558318
68Progressive hearing impairment (HP:0001730)2.25584537
69Erectile abnormalities (HP:0100639)2.22999883
70Lipid accumulation in hepatocytes (HP:0006561)2.22935662
71Absent epiphyses (HP:0010577)2.20605334
72Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.20605334
73Focal seizures (HP:0007359)2.19724914
74Humeroradial synostosis (HP:0003041)2.14237051
75Synostosis involving the elbow (HP:0003938)2.14237051
76Hepatic necrosis (HP:0002605)2.12755698
77Hypoplastic female external genitalia (HP:0012815)2.11672477
78Abnormality of the ischium (HP:0003174)2.05349024
79Postural tremor (HP:0002174)2.03915829
80Broad palm (HP:0001169)2.02971797
81Progressive external ophthalmoplegia (HP:0000590)2.02955932
82Abnormal ciliary motility (HP:0012262)2.02488716
83Loss of speech (HP:0002371)2.02248165
84Ketosis (HP:0001946)2.02173228
85Osteoarthritis (HP:0002758)2.00280868
86Narrow palate (HP:0000189)2.00275407
87Polyphagia (HP:0002591)1.98688179
88Hypertriglyceridemia (HP:0002155)1.97588686
89Hypophosphatemic rickets (HP:0004912)1.97348778
90Small hand (HP:0200055)1.96526494
91Mitochondrial inheritance (HP:0001427)1.95554945
92Autoamputation (HP:0001218)1.94442233
93Limb ataxia (HP:0002070)1.93701506
94Abnormality of incisor morphology (HP:0011063)1.93454536
95Status epilepticus (HP:0002133)1.90700487
96Congenital sensorineural hearing impairment (HP:0008527)1.87043232
97Short palm (HP:0004279)1.85882906
98Acute necrotizing encephalopathy (HP:0006965)1.85818845
99Increased hepatocellular lipid droplets (HP:0006565)1.85698690
100Genetic anticipation (HP:0003743)1.81795239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.37461964
2ARAF5.04931034
3MAP3K134.74563847
4DDR23.69222279
5PIM23.23397172
6TAOK13.16497234
7NTRK32.40092438
8MAP3K112.35987587
9CASK2.27037050
10RAF12.23446013
11MAP3K32.09008873
12CDK192.01926977
13EPHB11.83956364
14TAOK21.73973044
15PLK41.73831929
16BRAF1.59586758
17MKNK21.56696590
18MARK21.55366272
19PTK61.51431443
20GRK71.36676152
21PLK21.36269319
22MAP2K31.33892708
23MAP3K91.22459793
24FGFR31.20371821
25NTRK21.20021258
26RPS6KC11.16442654
27RPS6KL11.16442654
28MAP3K41.15618369
29PNCK1.07425552
30LATS21.06684387
31RPS6KA61.01418714
32MAP3K11.01177847
33MUSK1.00490375
34SCYL20.98291716
35UHMK10.94932168
36EPHA40.93584180
37DAPK20.90279088
38MAP3K120.81275444
39KSR20.79867492
40MAP3K140.79538357
41MAPK110.77395235
42MAP2K40.76402203
43TIE10.76218641
44MAP3K70.75633916
45LATS10.75163719
46MKNK10.72567918
47TRPM70.70261513
48WNK10.69488634
49MAPK130.67064224
50TNK20.65907554
51RPS6KB10.60772998
52IRAK20.59147804
53EPHA30.58404502
54MAP2K70.57638531
55MAP3K50.56877116
56MAP3K20.56671014
57NTRK10.51846284
58AKT30.51448284
59GRK50.51023139
60PDPK10.49407424
61FGFR10.49309545
62EPHB20.48799292
63CAMK2D0.48247297
64PTK2B0.47968162
65GRK10.47704429
66MINK10.46672484
67RPS6KA10.45543962
68PDK10.45297352
69PRKCQ0.44659160
70PHKG10.43735245
71PHKG20.43735245
72ERBB40.43553829
73OXSR10.43289209
74PRKCE0.41968372
75ROCK20.40529050
76IRAK10.40082528
77RET0.39997775
78BMPR20.38364856
79LMTK20.38356694
80CSNK1G30.37644951
81MARK10.36753932
82EIF2AK20.34562158
83FER0.34284254
84RIPK40.33810204
85STK380.33225744
86FYN0.30742373
87FES0.30704540
88CSNK1G20.29024698
89CAMK10.28201522
90PAK30.28152099
91CDK50.27892580
92ALK0.27127443
93PASK0.26839668
94TGFBR10.26090191
95PAK60.26018248
96NEK20.25339142
97JAK20.25153386
98ROCK10.25070683
99STK160.24707351
100AKT20.21748886

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38885893
2Long-term potentiation_Homo sapiens_hsa047202.42062977
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.16625670
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08213441
5Olfactory transduction_Homo sapiens_hsa047402.07969114
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02413871
7Phenylalanine metabolism_Homo sapiens_hsa003602.01477535
8GABAergic synapse_Homo sapiens_hsa047271.99395846
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.93556619
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.93251843
11Calcium signaling pathway_Homo sapiens_hsa040201.90258077
12Taste transduction_Homo sapiens_hsa047421.87639445
13Synaptic vesicle cycle_Homo sapiens_hsa047211.83696648
14Amphetamine addiction_Homo sapiens_hsa050311.70764968
15Dopaminergic synapse_Homo sapiens_hsa047281.63844490
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62160165
17Oxidative phosphorylation_Homo sapiens_hsa001901.55517398
18Parkinsons disease_Homo sapiens_hsa050121.54298819
19Morphine addiction_Homo sapiens_hsa050321.53733686
20Circadian entrainment_Homo sapiens_hsa047131.52841917
21Glutamatergic synapse_Homo sapiens_hsa047241.52545770
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48886987
23Cardiac muscle contraction_Homo sapiens_hsa042601.46468156
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.46396902
25Long-term depression_Homo sapiens_hsa047301.42977490
26Glucagon signaling pathway_Homo sapiens_hsa049221.41071177
27Gastric acid secretion_Homo sapiens_hsa049711.39053575
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38933267
29Alzheimers disease_Homo sapiens_hsa050101.38116787
30Melanogenesis_Homo sapiens_hsa049161.30127492
31Dilated cardiomyopathy_Homo sapiens_hsa054141.26690953
32Type II diabetes mellitus_Homo sapiens_hsa049301.24672827
33Renin secretion_Homo sapiens_hsa049241.22696688
34Fatty acid metabolism_Homo sapiens_hsa012121.22430931
35Prion diseases_Homo sapiens_hsa050201.20860523
36ECM-receptor interaction_Homo sapiens_hsa045121.20513701
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19229674
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16980441
39Salivary secretion_Homo sapiens_hsa049701.13827694
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13558063
41Insulin signaling pathway_Homo sapiens_hsa049101.11009285
42Cholinergic synapse_Homo sapiens_hsa047251.06252152
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.05321405
44Oxytocin signaling pathway_Homo sapiens_hsa049211.05229980
45Collecting duct acid secretion_Homo sapiens_hsa049661.01585280
46Protein digestion and absorption_Homo sapiens_hsa049741.00897571
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00284741
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.97664958
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95651091
50Vibrio cholerae infection_Homo sapiens_hsa051100.94614048
51Serotonergic synapse_Homo sapiens_hsa047260.93697756
52Insulin secretion_Homo sapiens_hsa049110.93676716
53Tyrosine metabolism_Homo sapiens_hsa003500.92812402
54mTOR signaling pathway_Homo sapiens_hsa041500.92528246
55Fatty acid degradation_Homo sapiens_hsa000710.88405592
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87709435
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85239204
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82830175
59Axon guidance_Homo sapiens_hsa043600.82049860
60Cocaine addiction_Homo sapiens_hsa050300.82007775
61Basal cell carcinoma_Homo sapiens_hsa052170.79986525
62Hippo signaling pathway_Homo sapiens_hsa043900.77897751
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77841764
64Wnt signaling pathway_Homo sapiens_hsa043100.77306505
65Oocyte meiosis_Homo sapiens_hsa041140.70557381
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69557497
67PPAR signaling pathway_Homo sapiens_hsa033200.68780496
68Dorso-ventral axis formation_Homo sapiens_hsa043200.67001810
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66613739
70Focal adhesion_Homo sapiens_hsa045100.66398023
71MAPK signaling pathway_Homo sapiens_hsa040100.65652741
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64037382
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62653415
74cAMP signaling pathway_Homo sapiens_hsa040240.61699463
75GnRH signaling pathway_Homo sapiens_hsa049120.61507912
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60508069
77Melanoma_Homo sapiens_hsa052180.60274341
78Histidine metabolism_Homo sapiens_hsa003400.59684681
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58970755
80Sulfur metabolism_Homo sapiens_hsa009200.58834244
81Tight junction_Homo sapiens_hsa045300.58246940
82Bile secretion_Homo sapiens_hsa049760.56854990
83Rap1 signaling pathway_Homo sapiens_hsa040150.56699210
84ABC transporters_Homo sapiens_hsa020100.55307968
85Starch and sucrose metabolism_Homo sapiens_hsa005000.53468783
86Hepatitis C_Homo sapiens_hsa051600.51574486
87Huntingtons disease_Homo sapiens_hsa050160.49845147
88Glioma_Homo sapiens_hsa052140.48362756
89Thyroid hormone synthesis_Homo sapiens_hsa049180.47695396
90AMPK signaling pathway_Homo sapiens_hsa041520.47675839
91ErbB signaling pathway_Homo sapiens_hsa040120.47454454
92Peroxisome_Homo sapiens_hsa041460.46239040
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45848497
94Gap junction_Homo sapiens_hsa045400.44240999
95Thyroid cancer_Homo sapiens_hsa052160.44010168
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43928845
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41089996
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.38140816
99Butanoate metabolism_Homo sapiens_hsa006500.38026475
100Fatty acid biosynthesis_Homo sapiens_hsa000610.37692551

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