KCNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)5.80720846
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66074912
3locomotory exploration behavior (GO:0035641)5.48186814
4synaptic vesicle maturation (GO:0016188)5.25140581
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21604715
6synaptic vesicle exocytosis (GO:0016079)5.17145770
7vocalization behavior (GO:0071625)5.13381873
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01303560
9glutamate secretion (GO:0014047)4.93643940
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79162277
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.73826566
12regulation of synaptic vesicle exocytosis (GO:2000300)4.70613367
13gamma-aminobutyric acid transport (GO:0015812)4.70549406
14neuron cell-cell adhesion (GO:0007158)4.55057363
15neurotransmitter secretion (GO:0007269)4.38974463
16regulation of glutamate receptor signaling pathway (GO:1900449)4.36967599
17cellular potassium ion homeostasis (GO:0030007)4.34784665
18glutamate receptor signaling pathway (GO:0007215)4.32942020
19protein localization to synapse (GO:0035418)4.28162566
20synaptic transmission, glutamatergic (GO:0035249)4.26942474
21central nervous system myelination (GO:0022010)4.17554105
22axon ensheathment in central nervous system (GO:0032291)4.17554105
23synaptic vesicle docking involved in exocytosis (GO:0016081)4.15809332
24regulation of synaptic vesicle transport (GO:1902803)4.14671556
25neuron-neuron synaptic transmission (GO:0007270)4.11228026
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.10614158
27exploration behavior (GO:0035640)4.07565326
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01152752
29cerebellar Purkinje cell differentiation (GO:0021702)3.97496340
30regulation of neuronal synaptic plasticity (GO:0048168)3.96963742
31cellular sodium ion homeostasis (GO:0006883)3.94340536
32transmission of nerve impulse (GO:0019226)3.94112840
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.85667105
34cerebellar granule cell differentiation (GO:0021707)3.81846408
35sodium ion export (GO:0071436)3.81470523
36L-amino acid import (GO:0043092)3.81040987
37long-term memory (GO:0007616)3.80534611
38neuromuscular process controlling posture (GO:0050884)3.79359725
39negative regulation of dendrite morphogenesis (GO:0050774)3.75463021
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.75076403
41neurotransmitter transport (GO:0006836)3.73511787
42layer formation in cerebral cortex (GO:0021819)3.70928614
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66823436
44regulation of synapse maturation (GO:0090128)3.66600249
45positive regulation of neurotransmitter secretion (GO:0001956)3.65973132
46G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.65905816
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64721983
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.64273619
49positive regulation of dendritic spine development (GO:0060999)3.61373876
50neurotransmitter-gated ion channel clustering (GO:0072578)3.60140759
51glycine transport (GO:0015816)3.59916483
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59069823
53positive regulation of membrane potential (GO:0045838)3.57898243
54regulation of ARF protein signal transduction (GO:0032012)3.54982278
55positive regulation of neurotransmitter transport (GO:0051590)3.52565361
56neurotransmitter uptake (GO:0001504)3.51403956
57regulation of postsynaptic membrane potential (GO:0060078)3.49905790
58dendritic spine morphogenesis (GO:0060997)3.47543252
59regulation of synapse structural plasticity (GO:0051823)3.46113348
60proline transport (GO:0015824)3.45756424
61serotonin metabolic process (GO:0042428)3.42513069
62membrane depolarization during action potential (GO:0086010)3.41524718
63regulation of neurotransmitter levels (GO:0001505)3.41220770
64positive regulation of dendritic spine morphogenesis (GO:0061003)3.41054460
65neuronal ion channel clustering (GO:0045161)3.39347823
66neuron recognition (GO:0008038)3.38084586
67presynaptic membrane assembly (GO:0097105)3.37334716
68acidic amino acid transport (GO:0015800)3.35329015
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.34546685
70presynaptic membrane organization (GO:0097090)3.34153466
71adult walking behavior (GO:0007628)3.33763234
72neuromuscular process controlling balance (GO:0050885)3.32328420
73regulation of neurotransmitter secretion (GO:0046928)3.31105781
74regulation of synaptic plasticity (GO:0048167)3.31040821
75long-term synaptic potentiation (GO:0060291)3.29342234
76membrane hyperpolarization (GO:0060081)3.29212099
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27309431
78synaptic vesicle endocytosis (GO:0048488)3.25894684
79regulation of dendritic spine development (GO:0060998)3.25169885
80cell communication involved in cardiac conduction (GO:0086065)3.23218233
81membrane depolarization (GO:0051899)3.21908658
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.20002982
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18892845
84auditory behavior (GO:0031223)3.17093309
85neuromuscular synaptic transmission (GO:0007274)3.14931586
86startle response (GO:0001964)3.14637170
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.14265225
88potassium ion import (GO:0010107)3.12915937
89vesicle docking involved in exocytosis (GO:0006904)3.12863944
90axonal fasciculation (GO:0007413)3.11343208
91detection of calcium ion (GO:0005513)3.11254362
92regulation of voltage-gated calcium channel activity (GO:1901385)3.11151954
93response to auditory stimulus (GO:0010996)3.10783416
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10663654
95regulation of dendritic spine morphogenesis (GO:0061001)3.10397457
96activation of protein kinase A activity (GO:0034199)3.10333211
97regulation of vesicle fusion (GO:0031338)3.09186647
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08515688
99regulation of neurotransmitter transport (GO:0051588)3.07914314
100dendrite morphogenesis (GO:0048813)3.07670213
101positive regulation of synapse maturation (GO:0090129)3.07174425
102postsynaptic membrane organization (GO:0001941)3.05931942
103amino acid import (GO:0043090)3.05263998
104cell differentiation in hindbrain (GO:0021533)3.03312502
105establishment of synaptic vesicle localization (GO:0097480)3.03036450
106synaptic vesicle transport (GO:0048489)3.03036450
107synapse assembly (GO:0007416)3.01221363
108potassium ion homeostasis (GO:0055075)3.00877513
109prepulse inhibition (GO:0060134)3.00104964
110cell communication by electrical coupling (GO:0010644)2.98812351
111neuromuscular process (GO:0050905)2.96101404
112* synaptic transmission (GO:0007268)2.95023672
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.93380893
114mating behavior (GO:0007617)2.92959017
115positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91948775
116learning (GO:0007612)2.90818085
117regulation of synaptic transmission (GO:0050804)2.87449472
118positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85221206
119mechanosensory behavior (GO:0007638)2.83452671
120positive regulation of synaptic transmission (GO:0050806)2.82743015
121synapse organization (GO:0050808)2.82676575
122response to histamine (GO:0034776)2.81860060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58313643
2GBX2_23144817_ChIP-Seq_PC3_Human3.63028777
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12369200
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11158261
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03243694
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73470354
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73470354
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57794369
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56313544
10REST_21632747_ChIP-Seq_MESCs_Mouse2.55832526
11DROSHA_22980978_ChIP-Seq_HELA_Human2.55805516
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52240360
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49230971
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47653991
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45643049
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.41880832
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.30800663
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.25775173
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.21902482
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19501023
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.15370008
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.04053242
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01463773
24AR_21572438_ChIP-Seq_LNCaP_Human1.92898800
25TAF15_26573619_Chip-Seq_HEK293_Human1.90588661
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88944447
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84725147
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74257132
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74129255
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72062355
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71282932
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68542656
33SMAD4_21799915_ChIP-Seq_A2780_Human1.67996975
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66863580
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65182535
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62954641
37* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59303414
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52193958
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48429697
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.45514038
41P300_19829295_ChIP-Seq_ESCs_Human1.41352421
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38197963
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37044362
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34564698
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.34278231
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.33106348
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32958324
48STAT3_23295773_ChIP-Seq_U87_Human1.30466887
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29719716
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.28518086
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.28354634
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26971912
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.26914597
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26377663
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25765087
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25553053
57ZNF274_21170338_ChIP-Seq_K562_Hela1.25476532
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.25424281
59AR_25329375_ChIP-Seq_VCAP_Human1.22005860
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21532323
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20335507
62AR_19668381_ChIP-Seq_PC3_Human1.20300367
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14746981
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14438401
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13932101
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13093280
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13051155
68TCF4_23295773_ChIP-Seq_U87_Human1.12897642
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11874941
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10447812
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.09868699
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09110487
73AHR_22903824_ChIP-Seq_MCF-7_Human1.08751688
74TP53_16413492_ChIP-PET_HCT116_Human1.05294259
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05150217
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.04740243
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04174878
78RNF2_27304074_Chip-Seq_NSC_Mouse1.04102838
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03819696
80TET1_21490601_ChIP-Seq_MESCs_Mouse1.02293015
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.01872545
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01552019
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00953282
84RUNX2_22187159_ChIP-Seq_PCA_Human1.00456372
85IGF1R_20145208_ChIP-Seq_DFB_Human0.99939409
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99765640
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99020746
88YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98231516
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97974628
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97270514
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97239575
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95522435
93* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94729556
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94599175
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94559567
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.93856782
97ER_23166858_ChIP-Seq_MCF-7_Human0.93106499
98NANOG_18555785_Chip-Seq_ESCs_Mouse0.93029082
99OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92992511
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92886281
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91819826
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91819826
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.91578048
104RXR_22108803_ChIP-Seq_LS180_Human0.88551829
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88274627
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.87772736
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87645790
108TP53_18474530_ChIP-ChIP_U2OS_Human0.87620475
109* KDM2B_26808549_Chip-Seq_K562_Human0.87412696
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86536182
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86412684
112SOX9_26525672_Chip-Seq_HEART_Mouse0.86011835
113VDR_22108803_ChIP-Seq_LS180_Human0.85951490
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85681126
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83860860
116CTCF_27219007_Chip-Seq_Bcells_Human0.83856055
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82025589
118KDM2B_26808549_Chip-Seq_REH_Human0.81359522
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81051816
120DPY_21335234_ChIP-Seq_ESCs_Mouse0.80860998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.91600843
2MP0003880_abnormal_central_pattern4.91080805
3* MP0003635_abnormal_synaptic_transmissio4.03293454
4MP0009046_muscle_twitch3.78495555
5MP0004270_analgesia3.74516707
6* MP0009745_abnormal_behavioral_response3.37634667
7* MP0002064_seizures3.29316961
8MP0001968_abnormal_touch/_nociception3.20649514
9MP0002063_abnormal_learning/memory/cond3.07361544
10* MP0002272_abnormal_nervous_system2.98166454
11MP0005423_abnormal_somatic_nervous2.88801899
12MP0002734_abnormal_mechanical_nocicepti2.80853490
13MP0001486_abnormal_startle_reflex2.80701273
14MP0002572_abnormal_emotion/affect_behav2.73294844
15MP0002736_abnormal_nociception_after2.51826553
16MP0002735_abnormal_chemical_nociception2.39245890
17MP0008569_lethality_at_weaning2.30837646
18* MP0002067_abnormal_sensory_capabilities2.24588701
19MP0001440_abnormal_grooming_behavior2.23224985
20MP0002822_catalepsy2.19821144
21MP0002733_abnormal_thermal_nociception2.12695917
22MP0001970_abnormal_pain_threshold2.06878870
23* MP0001501_abnormal_sleep_pattern1.99417062
24MP0003329_amyloid_beta_deposits1.96605481
25MP0002184_abnormal_innervation1.85697255
26MP0004142_abnormal_muscle_tone1.75809684
27MP0005386_behavior/neurological_phenoty1.75533855
28MP0004924_abnormal_behavior1.75533855
29MP0000778_abnormal_nervous_system1.74139755
30MP0004885_abnormal_endolymph1.70617897
31MP0002557_abnormal_social/conspecific_i1.70471344
32MP0004858_abnormal_nervous_system1.67385185
33MP0001984_abnormal_olfaction1.63784616
34MP0006276_abnormal_autonomic_nervous1.62653028
35MP0000955_abnormal_spinal_cord1.61336746
36MP0000920_abnormal_myelination1.60461701
37MP0004811_abnormal_neuron_physiology1.57261903
38MP0009780_abnormal_chondrocyte_physiolo1.55873852
39* MP0002066_abnormal_motor_capabilities/c1.49220789
40MP0003633_abnormal_nervous_system1.47194335
41MP0002882_abnormal_neuron_morphology1.46926173
42MP0003879_abnormal_hair_cell1.46615749
43MP0004145_abnormal_muscle_electrophysio1.44438537
44MP0005646_abnormal_pituitary_gland1.44314095
45MP0004742_abnormal_vestibular_system1.38511936
46MP0002909_abnormal_adrenal_gland1.37803154
47MP0003690_abnormal_glial_cell1.37591336
48MP0003631_nervous_system_phenotype1.30647288
49MP0001529_abnormal_vocalization1.28812777
50MP0003123_paternal_imprinting1.27977003
51MP0001905_abnormal_dopamine_level1.24048488
52MP0002229_neurodegeneration1.22632482
53MP0001502_abnormal_circadian_rhythm1.20332683
54MP0005645_abnormal_hypothalamus_physiol1.18511676
55MP0005551_abnormal_eye_electrophysiolog1.12793706
56MP0001485_abnormal_pinna_reflex1.12240575
57MP0003634_abnormal_glial_cell1.11465889
58MP0003632_abnormal_nervous_system1.11357149
59MP0002152_abnormal_brain_morphology1.06106759
60MP0001348_abnormal_lacrimal_gland1.05381110
61MP0003787_abnormal_imprinting1.05208368
62MP0008872_abnormal_physiological_respon1.00689840
63MP0001963_abnormal_hearing_physiology0.99563299
64MP0002638_abnormal_pupillary_reflex0.98154511
65MP0001188_hyperpigmentation0.93981243
66MP0000751_myopathy0.93765017
67MP0008874_decreased_physiological_sensi0.91926696
68MP0001177_atelectasis0.89404287
69MP0003122_maternal_imprinting0.89397266
70MP0000604_amyloidosis0.88114935
71MP0002752_abnormal_somatic_nervous0.87033351
72MP0001346_abnormal_lacrimal_gland0.85735269
73MP0002069_abnormal_eating/drinking_beha0.83920481
74MP0005409_darkened_coat_color0.80833965
75MP0000013_abnormal_adipose_tissue0.80252378
76MP0005623_abnormal_meninges_morphology0.80073470
77MP0004215_abnormal_myocardial_fiber0.78037126
78MP0005171_absent_coat_pigmentation0.76134522
79MP0005535_abnormal_body_temperature0.75930144
80MP0004085_abnormal_heartbeat0.75726500
81MP0010386_abnormal_urinary_bladder0.73802086
82MP0001299_abnormal_eye_distance/0.72724867
83MP0004043_abnormal_pH_regulation0.72269989
84MP0008877_abnormal_DNA_methylation0.70572642
85MP0002090_abnormal_vision0.69364142
86MP0003283_abnormal_digestive_organ0.69109238
87MP0003137_abnormal_impulse_conducting0.69094927
88MP0004484_altered_response_of0.67804635
89MP0005394_taste/olfaction_phenotype0.67754548
90MP0005499_abnormal_olfactory_system0.67754548
91MP0000569_abnormal_digit_pigmentation0.67733872
92MP0004130_abnormal_muscle_cell0.63180459
93MP0000631_abnormal_neuroendocrine_gland0.61746006
94MP0002837_dystrophic_cardiac_calcinosis0.59367198
95MP0003075_altered_response_to0.58885949
96MP0005167_abnormal_blood-brain_barrier0.56741176
97* MP0001943_abnormal_respiration0.55901378
98MP0004147_increased_porphyrin_level0.55351901
99MP0000747_muscle_weakness0.55332186
100MP0000026_abnormal_inner_ear0.54488301
101* MP0010769_abnormal_survival0.53957869
102MP0000579_abnormal_nail_morphology0.53949909
103MP0001664_abnormal_digestion0.51804351
104* MP0010770_preweaning_lethality0.51566274
105* MP0002082_postnatal_lethality0.51566274
106* MP0010768_mortality/aging0.50487024
107MP0001986_abnormal_taste_sensitivity0.50377026
108* MP0003956_abnormal_body_size0.49659020
109MP0003861_abnormal_nervous_system0.49316338
110MP0003172_abnormal_lysosome_physiology0.47180162
111MP0003121_genomic_imprinting0.46195035
112MP0004510_myositis0.45305542
113MP0003045_fibrosis0.43650615

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.92914903
2Myokymia (HP:0002411)6.49092381
3Focal seizures (HP:0007359)5.86897322
4Atonic seizures (HP:0010819)5.37748516
5Action tremor (HP:0002345)5.36211984
6Progressive cerebellar ataxia (HP:0002073)4.95553511
7Febrile seizures (HP:0002373)4.84235386
8Visual hallucinations (HP:0002367)4.80472439
9Epileptic encephalopathy (HP:0200134)4.68592218
10Absence seizures (HP:0002121)4.26768202
11Gaze-evoked nystagmus (HP:0000640)4.07010472
12Dialeptic seizures (HP:0011146)3.94987179
13Generalized tonic-clonic seizures (HP:0002069)3.92100934
14Supranuclear gaze palsy (HP:0000605)3.79640199
15Broad-based gait (HP:0002136)3.65082707
16Dysdiadochokinesis (HP:0002075)3.59229002
17Dysmetria (HP:0001310)3.57231466
18Scanning speech (HP:0002168)3.52229577
19Obstructive sleep apnea (HP:0002870)3.41095672
20Ankle clonus (HP:0011448)3.29806564
21Truncal ataxia (HP:0002078)3.26255839
22Poor eye contact (HP:0000817)3.18428127
23Termporal pattern (HP:0011008)3.16155743
24Insidious onset (HP:0003587)3.16155743
25Hyperventilation (HP:0002883)3.13729830
26Intention tremor (HP:0002080)3.10519784
27Cerebral hypomyelination (HP:0006808)3.06711186
28Impaired vibration sensation in the lower limbs (HP:0002166)3.02508272
29Urinary bladder sphincter dysfunction (HP:0002839)3.02480284
30Impaired social interactions (HP:0000735)2.99094420
31Abnormal social behavior (HP:0012433)2.99094420
32Hemiparesis (HP:0001269)2.98812359
33Spastic gait (HP:0002064)2.96743920
34Hemiplegia (HP:0002301)2.94147564
35Postural instability (HP:0002172)2.92152694
36Abnormal eating behavior (HP:0100738)2.91547197
37Abnormality of binocular vision (HP:0011514)2.87082667
38Diplopia (HP:0000651)2.87082667
39Depression (HP:0000716)2.86592254
40Neurofibrillary tangles (HP:0002185)2.81005630
41Anxiety (HP:0000739)2.79128926
42Impaired smooth pursuit (HP:0007772)2.78079847
43Abnormality of the corticospinal tract (HP:0002492)2.76672237
44Genetic anticipation (HP:0003743)2.74567324
45Peripheral hypomyelination (HP:0007182)2.68465795
46Akinesia (HP:0002304)2.60406066
47Pheochromocytoma (HP:0002666)2.58036051
48Dysmetric saccades (HP:0000641)2.57525121
49Urinary urgency (HP:0000012)2.56857284
50Amblyopia (HP:0000646)2.55045854
51Status epilepticus (HP:0002133)2.51902644
52Progressive inability to walk (HP:0002505)2.50882537
53Abnormality of ocular smooth pursuit (HP:0000617)2.45101402
54Delusions (HP:0000746)2.44048325
55Ulnar claw (HP:0001178)2.43240902
56Sleep apnea (HP:0010535)2.42932627
57Cerebral inclusion bodies (HP:0100314)2.41198031
58Fetal akinesia sequence (HP:0001989)2.34840500
59Drooling (HP:0002307)2.31871373
60Excessive salivation (HP:0003781)2.31871373
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.30255141
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30255141
63Absent speech (HP:0001344)2.28938450
64Postural tremor (HP:0002174)2.28923961
65Mutism (HP:0002300)2.27996992
66Papilledema (HP:0001085)2.27484143
67Stereotypic behavior (HP:0000733)2.26207807
68Ventricular fibrillation (HP:0001663)2.26127880
69Spastic tetraparesis (HP:0001285)2.26113900
70Neuroendocrine neoplasm (HP:0100634)2.24380603
71Lower limb muscle weakness (HP:0007340)2.23927672
72Abnormality of saccadic eye movements (HP:0000570)2.22981631
73Megalencephaly (HP:0001355)2.22950371
74Apathy (HP:0000741)2.19948505
75Bradykinesia (HP:0002067)2.19216627
76Onion bulb formation (HP:0003383)2.15263749
77Epileptiform EEG discharges (HP:0011182)2.13381059
78Impaired vibratory sensation (HP:0002495)2.13008817
79Gait ataxia (HP:0002066)2.12679711
80Generalized myoclonic seizures (HP:0002123)2.12417416
81Morphological abnormality of the pyramidal tract (HP:0002062)2.12327006
82Insomnia (HP:0100785)2.10847224
83Torticollis (HP:0000473)2.10258231
84Increased circulating renin level (HP:0000848)2.06731315
85Annular pancreas (HP:0001734)2.06466679
86Abnormality of the lower motor neuron (HP:0002366)2.05576383
87CNS hypomyelination (HP:0003429)2.05420156
88Aplasia involving bones of the extremities (HP:0009825)2.05413671
89Aplasia involving bones of the upper limbs (HP:0009823)2.05413671
90Aplasia of the phalanges of the hand (HP:0009802)2.05413671
91EEG with generalized epileptiform discharges (HP:0011198)2.04739398
92Choreoathetosis (HP:0001266)2.04442061
93Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02056413
94Rapidly progressive (HP:0003678)2.00971460
95Blue irides (HP:0000635)1.98882272
96Limb dystonia (HP:0002451)1.98876886
97Clonus (HP:0002169)1.98024625
98Bundle branch block (HP:0011710)1.96028452
99Focal dystonia (HP:0004373)1.94925965
100Diminished motivation (HP:0000745)1.94533442
101Inability to walk (HP:0002540)1.93155987
102Hypsarrhythmia (HP:0002521)1.91106114
103Neuronal loss in central nervous system (HP:0002529)1.88798158
104Psychosis (HP:0000709)1.85391273
105Hammertoe (HP:0001765)1.84315514
106Memory impairment (HP:0002354)1.82554420
107Incomplete penetrance (HP:0003829)1.79664345
108Tetraplegia (HP:0002445)1.78933048
109Retinal dysplasia (HP:0007973)1.77595916
110Polyphagia (HP:0002591)1.77413288
111Agitation (HP:0000713)1.76032747
112Spastic tetraplegia (HP:0002510)1.75781935
113Amyotrophic lateral sclerosis (HP:0007354)1.75005227
114Rigidity (HP:0002063)1.72008178
115Specific learning disability (HP:0001328)1.70865113
116Prolonged QT interval (HP:0001657)1.70167593
117Craniofacial dystonia (HP:0012179)1.69443666
118Slow saccadic eye movements (HP:0000514)1.67215442
119Lower limb asymmetry (HP:0100559)1.66625141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.29271821
2EPHA43.72322280
3MAP3K93.37774932
4MAP3K42.98220271
5MINK12.57824110
6TNIK2.53420956
7MAP2K72.49291171
8PAK62.22873197
9CASK2.20983430
10MARK12.16588375
11DAPK22.14790143
12NTRK22.09617361
13RIPK42.06674615
14NTRK12.04856838
15MAP2K41.97283145
16MAP3K121.80545674
17CDK191.78377623
18KSR21.77661185
19CAMKK11.75358261
20PNCK1.72855744
21CAMKK21.62526240
22OXSR11.61786368
23PRKD31.61359708
24CDK51.52201325
25WNK11.45728147
26STK391.44183365
27PRPF4B1.42480805
28STK381.40945318
29MAPK131.38476583
30GRK51.35416164
31UHMK11.33027085
32FES1.28708510
33PRKCG1.22663830
34TYRO31.21675328
35PLK21.20767557
36SGK4941.14822049
37SGK2231.14822049
38ARAF1.10569767
39KSR11.10374325
40MAP3K21.08881397
41MAP3K131.07306253
42PHKG11.05342320
43PHKG21.05342320
44DAPK11.05317811
45CAMK2A1.02976065
46CAMK2B0.96136611
47LMTK20.94209477
48SIK20.93560534
49NEK60.93340393
50STK110.93052806
51CAMK10.89685155
52PRKCH0.88884111
53PINK10.88367325
54SGK20.85194690
55RET0.85152194
56CDK150.84530047
57CDK180.84407971
58CDK140.83069916
59BMPR20.78821440
60TNK20.77656792
61MAPK120.75815131
62CSNK1G20.73541638
63SGK10.72748923
64CDK11A0.72593791
65PDPK10.71601617
66ROCK20.71282353
67PAK30.70906367
68CAMK2D0.70646147
69CAMK2G0.70565192
70SGK30.70564237
71PDK10.67641628
72CAMK1G0.65000093
73PTK2B0.64267543
74MARK20.64068325
75WNK40.62091237
76TAOK10.60624366
77PKN10.60144639
78CDC42BPA0.59180715
79PRKCE0.59087689
80BRSK10.58220282
81MAPKAPK50.58177480
82DYRK1A0.58074482
83LATS20.54410983
84ALK0.53364994
85FYN0.52947204
86RAF10.51912343
87RPS6KA30.51311007
88FGFR20.51208794
89FGR0.50350632
90MAP3K10.48935995
91CCNB10.48816094
92BRAF0.48588846
93MAPK100.47512712
94RIPK10.45336033
95BCR0.44295705
96MUSK0.42588681
97PRKCZ0.42200785
98LIMK10.41082523
99CAMK40.40083345
100IRAK20.38627906
101PRKG10.38029283
102PRKACA0.36585208
103DAPK30.36482596
104MAP3K70.36393136
105FER0.36256620
106PRKCA0.35685859
107ICK0.35219854
108ERBB20.33315083
109MAP3K110.32191556
110PRKCB0.31766744
111CSNK1D0.28622391
112MAP2K10.27495701
113ROCK10.27168329
114SRC0.25417756

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94007802
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20761073
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77710752
4GABAergic synapse_Homo sapiens_hsa047272.77346929
5Glutamatergic synapse_Homo sapiens_hsa047242.76936051
6Circadian entrainment_Homo sapiens_hsa047132.59864053
7Long-term potentiation_Homo sapiens_hsa047202.57267240
8Morphine addiction_Homo sapiens_hsa050322.50096994
9Olfactory transduction_Homo sapiens_hsa047402.47913218
10Salivary secretion_Homo sapiens_hsa049702.28441734
11Amphetamine addiction_Homo sapiens_hsa050312.23580822
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09874756
13Dopaminergic synapse_Homo sapiens_hsa047282.02881804
14Taste transduction_Homo sapiens_hsa047421.98542520
15Gastric acid secretion_Homo sapiens_hsa049711.95005798
16Insulin secretion_Homo sapiens_hsa049111.92315654
17Long-term depression_Homo sapiens_hsa047301.83851636
18Cholinergic synapse_Homo sapiens_hsa047251.81663983
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70931825
20Serotonergic synapse_Homo sapiens_hsa047261.68564158
21Renin secretion_Homo sapiens_hsa049241.62588093
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60466566
23Calcium signaling pathway_Homo sapiens_hsa040201.58462689
24Oxytocin signaling pathway_Homo sapiens_hsa049211.55307526
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55281338
26Collecting duct acid secretion_Homo sapiens_hsa049661.47746507
27Nitrogen metabolism_Homo sapiens_hsa009101.45188272
28Cocaine addiction_Homo sapiens_hsa050301.44179390
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40632698
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35271941
31GnRH signaling pathway_Homo sapiens_hsa049121.34895668
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32631149
33cAMP signaling pathway_Homo sapiens_hsa040241.28112697
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25365723
35Gap junction_Homo sapiens_hsa045401.24833055
36Type II diabetes mellitus_Homo sapiens_hsa049301.15557779
37Axon guidance_Homo sapiens_hsa043601.12570491
38Cardiac muscle contraction_Homo sapiens_hsa042601.11782652
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10491435
40Vitamin B6 metabolism_Homo sapiens_hsa007501.10479447
41Estrogen signaling pathway_Homo sapiens_hsa049151.07319739
42Pancreatic secretion_Homo sapiens_hsa049721.05136670
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99817590
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96950204
45Dorso-ventral axis formation_Homo sapiens_hsa043200.94617107
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.93640686
47ErbB signaling pathway_Homo sapiens_hsa040120.92922898
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92382872
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.91724856
50Phototransduction_Homo sapiens_hsa047440.91610966
51Melanogenesis_Homo sapiens_hsa049160.91263417
52Glioma_Homo sapiens_hsa052140.87858380
53Vibrio cholerae infection_Homo sapiens_hsa051100.86276835
54Thyroid hormone synthesis_Homo sapiens_hsa049180.84510985
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81469438
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.78088036
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75261772
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74509375
59Choline metabolism in cancer_Homo sapiens_hsa052310.73011029
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70998170
61Dilated cardiomyopathy_Homo sapiens_hsa054140.70121912
62MAPK signaling pathway_Homo sapiens_hsa040100.68363800
63Oocyte meiosis_Homo sapiens_hsa041140.67656767
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66912718
65Bile secretion_Homo sapiens_hsa049760.60723544
66Inositol phosphate metabolism_Homo sapiens_hsa005620.59453474
67Ras signaling pathway_Homo sapiens_hsa040140.56978753
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.55357933
69Alzheimers disease_Homo sapiens_hsa050100.54830041
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52429427
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52018069
72Rap1 signaling pathway_Homo sapiens_hsa040150.50058331
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47610458
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.46180845
75Endocytosis_Homo sapiens_hsa041440.45380606
76VEGF signaling pathway_Homo sapiens_hsa043700.45102160
77Circadian rhythm_Homo sapiens_hsa047100.43568064
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43518413
79Glucagon signaling pathway_Homo sapiens_hsa049220.41624094
80Fatty acid biosynthesis_Homo sapiens_hsa000610.41168699
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41142211
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40338422
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40222862
84Ovarian steroidogenesis_Homo sapiens_hsa049130.38027136
85Oxidative phosphorylation_Homo sapiens_hsa001900.37552260
86Alcoholism_Homo sapiens_hsa050340.37279101
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.36609479
88Type I diabetes mellitus_Homo sapiens_hsa049400.35275416
89African trypanosomiasis_Homo sapiens_hsa051430.34318852
90Wnt signaling pathway_Homo sapiens_hsa043100.34247060
91Renal cell carcinoma_Homo sapiens_hsa052110.33519049
92Mineral absorption_Homo sapiens_hsa049780.32631095
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32504027
94Prion diseases_Homo sapiens_hsa050200.30592049
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29548374
96Ether lipid metabolism_Homo sapiens_hsa005650.29393276
97Chemokine signaling pathway_Homo sapiens_hsa040620.28961192
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28878731
99mTOR signaling pathway_Homo sapiens_hsa041500.28799485
100Arginine and proline metabolism_Homo sapiens_hsa003300.28220933
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27917132
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27470869
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27117170
104Histidine metabolism_Homo sapiens_hsa003400.26456859
105Insulin signaling pathway_Homo sapiens_hsa049100.24130827
106Rheumatoid arthritis_Homo sapiens_hsa053230.23294434
107Tight junction_Homo sapiens_hsa045300.22985514
108Arginine biosynthesis_Homo sapiens_hsa002200.21751951
109Endometrial cancer_Homo sapiens_hsa052130.20705711
110AMPK signaling pathway_Homo sapiens_hsa041520.19770173
111beta-Alanine metabolism_Homo sapiens_hsa004100.17819302
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16453089

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »