KCNA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)6.28359578
2protein localization to synapse (GO:0035418)5.45576410
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42998674
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.33933005
5vocalization behavior (GO:0071625)5.21206262
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.20810585
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.04304385
8glutamate receptor signaling pathway (GO:0007215)4.99852998
9neuron cell-cell adhesion (GO:0007158)4.86125699
10positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.76395658
11regulation of glutamate receptor signaling pathway (GO:1900449)4.64413769
12locomotory exploration behavior (GO:0035641)4.62059062
13glucocorticoid receptor signaling pathway (GO:0042921)4.58384514
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.56393618
15neuron-neuron synaptic transmission (GO:0007270)4.56248850
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.54622912
17synaptic vesicle exocytosis (GO:0016079)4.52543735
18synaptic transmission, glutamatergic (GO:0035249)4.36468868
19nerve growth factor signaling pathway (GO:0038180)4.34650398
20behavioral response to cocaine (GO:0048148)4.31805592
21negative regulation of activin receptor signaling pathway (GO:0032926)4.30382118
22synaptic transmission, dopaminergic (GO:0001963)4.23790355
23G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.23768408
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21896488
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.20810916
26synaptic vesicle maturation (GO:0016188)4.20303173
27response to histamine (GO:0034776)4.19903320
28neurotransmitter-gated ion channel clustering (GO:0072578)4.18617626
29regulation of neuronal synaptic plasticity (GO:0048168)4.18501873
30negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.17242079
31glutamate secretion (GO:0014047)4.12949209
32exploration behavior (GO:0035640)4.12758179
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.11281345
34negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10199744
35negative regulation of response to food (GO:0032096)4.09177537
36negative regulation of appetite (GO:0032099)4.09177537
37regulation of synaptic vesicle exocytosis (GO:2000300)4.06163951
38neuronal action potential propagation (GO:0019227)4.04509894
39regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.04348363
40long-term memory (GO:0007616)3.99596550
41behavioral fear response (GO:0001662)3.97224731
42behavioral defense response (GO:0002209)3.97224731
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.95458446
44regulation of synapse structural plasticity (GO:0051823)3.93714522
45neuron recognition (GO:0008038)3.92565328
46regulation of glutamate secretion (GO:0014048)3.90788552
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88985934
48regulation of postsynaptic membrane potential (GO:0060078)3.87531492
49long-term synaptic potentiation (GO:0060291)3.81414639
50dendritic spine morphogenesis (GO:0060997)3.81340468
51cellular response to nerve growth factor stimulus (GO:1990090)3.79911634
52response to nerve growth factor (GO:1990089)3.79911634
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79492005
54transmission of nerve impulse (GO:0019226)3.78938720
55regulation of dendritic spine morphogenesis (GO:0061001)3.76373586
56regulation of synaptic vesicle transport (GO:1902803)3.73588000
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.72454960
58regulation of synaptic plasticity (GO:0048167)3.67377514
59protein insertion into membrane (GO:0051205)3.66877257
60cell communication involved in cardiac conduction (GO:0086065)3.65255021
61prepulse inhibition (GO:0060134)3.64724617
62fear response (GO:0042596)3.64200398
63corticosteroid receptor signaling pathway (GO:0031958)3.62273718
64proline transport (GO:0015824)3.62226491
65presynaptic membrane assembly (GO:0097105)3.61576453
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.61164841
67positive regulation of membrane potential (GO:0045838)3.61001499
68adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.59032805
69synaptic vesicle docking involved in exocytosis (GO:0016081)3.59006263
70axon extension (GO:0048675)3.58346943
71positive regulation of synapse maturation (GO:0090129)3.58041331
72neurotransmitter secretion (GO:0007269)3.55512290
73axonal fasciculation (GO:0007413)3.52105112
74atrial cardiac muscle cell action potential (GO:0086014)3.51688158
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.51639108
76striatum development (GO:0021756)3.51272396
77negative regulation of amino acid transport (GO:0051956)3.45342883
78response to amphetamine (GO:0001975)3.44497285
79regulation of female receptivity (GO:0045924)3.44197970
80layer formation in cerebral cortex (GO:0021819)3.41430370
81regulation of collateral sprouting (GO:0048670)3.39629316
82regulation of glycogen (starch) synthase activity (GO:2000465)3.38618411
83positive regulation of neurotransmitter secretion (GO:0001956)3.36613612
84behavioral response to nicotine (GO:0035095)3.35958143
85learning (GO:0007612)3.34453066
86neuronal action potential (GO:0019228)3.34174333
87long term synaptic depression (GO:0060292)3.33868699
88postsynaptic membrane organization (GO:0001941)3.29998264
89membrane depolarization (GO:0051899)3.29633531
90presynaptic membrane organization (GO:0097090)3.29490066
91cell communication by electrical coupling (GO:0010644)3.29437168
92regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28383820
93G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26769857
94mating behavior (GO:0007617)3.26124999
95sodium ion export (GO:0071436)3.25932518
96sleep (GO:0030431)3.25278305
97female mating behavior (GO:0060180)3.24834063
98dendritic spine organization (GO:0097061)3.23816227
99regulation of dendritic spine development (GO:0060998)3.23310606
100positive regulation of neurotransmitter transport (GO:0051590)3.21406250
101gamma-aminobutyric acid transport (GO:0015812)3.21286476
102dopaminergic neuron differentiation (GO:0071542)3.20669066
103cellular sodium ion homeostasis (GO:0006883)3.20079191
104glomerular visceral epithelial cell development (GO:0072015)3.18095258
105phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.17924375
106neuron projection extension (GO:1990138)3.17563629
107membrane depolarization during action potential (GO:0086010)3.17098992
108positive regulation of dendritic spine morphogenesis (GO:0061003)3.16644932
109dopamine receptor signaling pathway (GO:0007212)3.15167526
110multicellular organismal signaling (GO:0035637)3.15126540
111cellular potassium ion homeostasis (GO:0030007)3.14607876
112positive regulation of dendritic spine development (GO:0060999)3.13607379
113regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.12823101
114regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.12823101
115synaptic vesicle endocytosis (GO:0048488)3.12448650
116regulation of synaptic transmission, GABAergic (GO:0032228)3.12396012
117regulation of vesicle fusion (GO:0031338)3.11620573
118urinary tract smooth muscle contraction (GO:0014848)3.11614981
119innervation (GO:0060384)3.11610134
120serotonin receptor signaling pathway (GO:0007210)3.11036908
121pyrimidine nucleobase catabolic process (GO:0006208)3.10859314
122neurotransmitter transport (GO:0006836)3.08146745
123serotonin metabolic process (GO:0042428)3.07815307
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06847279
125auditory behavior (GO:0031223)3.05229945
126positive regulation of synaptic transmission (GO:0050806)3.04786730
127regulation of neurotransmitter secretion (GO:0046928)3.03747034
128membrane hyperpolarization (GO:0060081)3.02013840
129synapse assembly (GO:0007416)3.01187808
130response to auditory stimulus (GO:0010996)3.00650085
131startle response (GO:0001964)3.00048861
132detection of calcium ion (GO:0005513)2.98083391
133response to insecticide (GO:0017085)2.96428010
134positive regulation of sodium ion transport (GO:0010765)2.95282211
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.94305689
136protein localization to cilium (GO:0061512)2.92433088
137C4-dicarboxylate transport (GO:0015740)2.91828269
138positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.90164155
139regulation of sodium ion transmembrane transporter activity (GO:2000649)2.86549320
140negative regulation of cAMP metabolic process (GO:0030815)2.83256828
141glomerular epithelial cell development (GO:0072310)2.80758291
142action potential (GO:0001508)2.77881125
143dendrite morphogenesis (GO:0048813)2.77667866
144regulation of synapse maturation (GO:0090128)2.77304396
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.76149688
146regulation of amino acid transport (GO:0051955)2.74760350
147negative regulation of cyclic nucleotide metabolic process (GO:0030800)2.74173029
148ventricular cardiac muscle cell action potential (GO:0086005)2.73316973
149regulation of axon guidance (GO:1902667)2.73002947
150negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72188707
151cerebellar granule cell differentiation (GO:0021707)2.70293082
152regulation of response to food (GO:0032095)2.69411362
153phosphorelay signal transduction system (GO:0000160)2.68594595
154positive regulation of neuroblast proliferation (GO:0002052)2.68195113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.39161070
2GBX2_23144817_ChIP-Seq_PC3_Human4.08626557
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18331252
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15673791
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14042791
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69464343
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64333116
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64333116
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61037952
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.54652550
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53961822
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.53835188
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.53100846
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51492284
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42277177
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.37289129
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36304066
18DROSHA_22980978_ChIP-Seq_HELA_Human2.19024862
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.12921757
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12550017
21TAF15_26573619_Chip-Seq_HEK293_Human2.08938595
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.08216179
23* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01320668
24* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00772605
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99371967
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97349069
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.95308218
28* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85381435
29AR_21572438_ChIP-Seq_LNCaP_Human1.82538526
30* SMAD4_21799915_ChIP-Seq_A2780_Human1.81674105
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79590449
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78959348
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77768458
34* P300_19829295_ChIP-Seq_ESCs_Human1.73871561
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69421315
36* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67915113
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61879338
38ZNF274_21170338_ChIP-Seq_K562_Hela1.54833285
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53726110
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.52729623
41FUS_26573619_Chip-Seq_HEK293_Human1.52469035
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48930878
43* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48007051
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.47627886
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46923446
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46622453
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44845145
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41501003
49AR_25329375_ChIP-Seq_VCAP_Human1.41467212
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39171482
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39078578
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.36452606
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34486381
54* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33342854
55STAT3_23295773_ChIP-Seq_U87_Human1.32218509
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.32106731
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31534869
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.30837721
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.29963391
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28015218
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27782159
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23773759
63IGF1R_20145208_ChIP-Seq_DFB_Human1.23424007
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.22919882
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22005467
66* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20669617
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20559269
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18345157
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.18022798
70TCF4_23295773_ChIP-Seq_U87_Human1.17515993
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16970616
72RNF2_27304074_Chip-Seq_NSC_Mouse1.15952574
73* AR_19668381_ChIP-Seq_PC3_Human1.14760792
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12716020
75TP53_16413492_ChIP-PET_HCT116_Human1.12596515
76VDR_22108803_ChIP-Seq_LS180_Human1.12586100
77TP53_18474530_ChIP-ChIP_U2OS_Human1.12047281
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.11726914
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.11427353
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11257837
81RUNX2_22187159_ChIP-Seq_PCA_Human1.10869375
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10288380
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09024282
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.07653414
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07011080
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06671029
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.06338755
88* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06142198
89* JUN_21703547_ChIP-Seq_K562_Human1.05943134
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05771387
91AHR_22903824_ChIP-Seq_MCF-7_Human1.05728923
92* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05464738
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05365196
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05259837
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03262628
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03199063
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03184352
98* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02081961
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01726312
100BCAT_22108803_ChIP-Seq_LS180_Human1.01498611
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01405771
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01405771
103* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01148705
104TBL1_22424771_ChIP-Seq_293T_Human1.00088701
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98309457
106PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97906497
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94829118
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.94702496
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91314456
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91275155
111* ER_23166858_ChIP-Seq_MCF-7_Human0.90877009
112KDM2B_26808549_Chip-Seq_REH_Human0.89822131
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.89453193
114RXR_22108803_ChIP-Seq_LS180_Human0.89303601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.34522053
2MP0003880_abnormal_central_pattern5.43041321
3MP0003635_abnormal_synaptic_transmissio4.12715899
4MP0009745_abnormal_behavioral_response3.77332440
5MP0002822_catalepsy3.75193948
6MP0003950_abnormal_plasma_membrane3.62819201
7MP0004270_analgesia3.53878870
8MP0002063_abnormal_learning/memory/cond3.52065467
9MP0001968_abnormal_touch/_nociception3.28358887
10* MP0002064_seizures3.06121188
11MP0002572_abnormal_emotion/affect_behav2.94564005
12MP0002736_abnormal_nociception_after2.74568837
13MP0002272_abnormal_nervous_system2.74052623
14MP0002735_abnormal_chemical_nociception2.71042115
15MP0009046_muscle_twitch2.67220619
16MP0001486_abnormal_startle_reflex2.53524301
17MP0001501_abnormal_sleep_pattern2.47943037
18MP0002734_abnormal_mechanical_nocicepti2.35797467
19MP0001440_abnormal_grooming_behavior2.24720719
20MP0003567_abnormal_fetal_cardiomyocyte2.16712101
21MP0005423_abnormal_somatic_nervous2.16120485
22MP0001529_abnormal_vocalization2.15154571
23MP0002733_abnormal_thermal_nociception2.12631989
24MP0006276_abnormal_autonomic_nervous2.11627171
25MP0001188_hyperpigmentation2.01775880
26MP0002067_abnormal_sensory_capabilities2.00983713
27MP0001970_abnormal_pain_threshold1.98757134
28MP0004924_abnormal_behavior1.87181364
29MP0005386_behavior/neurological_phenoty1.87181364
30MP0002184_abnormal_innervation1.76704417
31MP0002557_abnormal_social/conspecific_i1.74841610
32MP0000778_abnormal_nervous_system1.74727288
33MP0003868_abnormal_feces_composition1.71245155
34MP0002909_abnormal_adrenal_gland1.67786542
35MP0001905_abnormal_dopamine_level1.62929862
36MP0005646_abnormal_pituitary_gland1.61793871
37MP0003329_amyloid_beta_deposits1.61091708
38MP0003879_abnormal_hair_cell1.56543233
39MP0004811_abnormal_neuron_physiology1.54419379
40MP0008569_lethality_at_weaning1.53294618
41MP0004130_abnormal_muscle_cell1.46155346
42MP0004858_abnormal_nervous_system1.44607856
43MP0001984_abnormal_olfaction1.37798005
44MP0009780_abnormal_chondrocyte_physiolo1.37149078
45MP0002066_abnormal_motor_capabilities/c1.34117007
46MP0003121_genomic_imprinting1.31842592
47MP0002882_abnormal_neuron_morphology1.31210434
48MP0000955_abnormal_spinal_cord1.28050617
49MP0001502_abnormal_circadian_rhythm1.27620961
50MP0005409_darkened_coat_color1.26174959
51MP0003787_abnormal_imprinting1.25294003
52MP0003633_abnormal_nervous_system1.22686664
53MP0004264_abnormal_extraembryonic_tissu1.22546372
54MP0002837_dystrophic_cardiac_calcinosis1.22011641
55MP0004142_abnormal_muscle_tone1.21860819
56MP0004885_abnormal_endolymph1.20614500
57MP0000639_abnormal_adrenal_gland1.09669067
58MP0004145_abnormal_muscle_electrophysio1.09440744
59MP0000566_synostosis1.09406965
60MP0004084_abnormal_cardiac_muscle1.07656607
61MP0005645_abnormal_hypothalamus_physiol1.05432748
62MP0005248_abnormal_Harderian_gland1.05348001
63MP0000751_myopathy1.03714806
64MP0005551_abnormal_eye_electrophysiolog1.03706012
65MP0003631_nervous_system_phenotype1.03499209
66MP0003045_fibrosis1.03197217
67MP0008874_decreased_physiological_sensi1.01856429
68MP0004742_abnormal_vestibular_system1.01527686
69MP0004085_abnormal_heartbeat1.00370201
70MP0002152_abnormal_brain_morphology0.96433641
71MP0002069_abnormal_eating/drinking_beha0.95800572
72MP0008872_abnormal_physiological_respon0.93838135
73MP0005535_abnormal_body_temperature0.91319976
74MP0005410_abnormal_fertilization0.91207895
75MP0002229_neurodegeneration0.90614526
76MP0002160_abnormal_reproductive_system0.89283057
77MP0004147_increased_porphyrin_level0.88764696
78MP0005253_abnormal_eye_physiology0.88219574
79MP0000462_abnormal_digestive_system0.87969644
80MP0005365_abnormal_bile_salt0.87880097
81MP0005171_absent_coat_pigmentation0.87281761
82MP0002876_abnormal_thyroid_physiology0.85319203
83MP0001919_abnormal_reproductive_system0.85006438
84MP0002106_abnormal_muscle_physiology0.83118337
85MP0001963_abnormal_hearing_physiology0.82994702
86MP0003890_abnormal_embryonic-extraembry0.81585098
87MP0010386_abnormal_urinary_bladder0.81289883
88MP0004510_myositis0.81131967
89MP0000647_abnormal_sebaceous_gland0.80312662
90MP0001485_abnormal_pinna_reflex0.78914741
91MP0001346_abnormal_lacrimal_gland0.77125393
92MP0002752_abnormal_somatic_nervous0.76010246
93MP0000569_abnormal_digit_pigmentation0.75496560
94MP0003122_maternal_imprinting0.74242549
95MP0008961_abnormal_basal_metabolism0.73820827
96MP0001664_abnormal_digestion0.73774861
97MP0004484_altered_response_of0.73226823
98MP0001177_atelectasis0.72626186
99MP0004215_abnormal_myocardial_fiber0.71737939
100MP0000631_abnormal_neuroendocrine_gland0.71459112
101MP0000013_abnormal_adipose_tissue0.68523451
102MP0006292_abnormal_olfactory_placode0.68234838
103MP0009278_abnormal_bone_marrow0.67919326
104MP0004233_abnormal_muscle_weight0.67671434
105MP0003698_abnormal_male_reproductive0.66910816
106MP0003634_abnormal_glial_cell0.66369712
107MP0000920_abnormal_myelination0.66039789
108MP0003137_abnormal_impulse_conducting0.65906086
109MP0005369_muscle_phenotype0.65815118
110MP0000604_amyloidosis0.65773265
111MP0000230_abnormal_systemic_arterial0.65604965
112MP0003632_abnormal_nervous_system0.64629722
113MP0005310_abnormal_salivary_gland0.64158455
114MP0003075_altered_response_to0.63733457
115MP0006072_abnormal_retinal_apoptosis0.62538094
116MP0005379_endocrine/exocrine_gland_phen0.62326669
117MP0002090_abnormal_vision0.61860933
118MP0008877_abnormal_DNA_methylation0.61679422
119MP0003690_abnormal_glial_cell0.59625050
120MP0000026_abnormal_inner_ear0.53722663
121MP0005499_abnormal_olfactory_system0.51308274
122MP0005394_taste/olfaction_phenotype0.51308274
123MP0002234_abnormal_pharynx_morphology0.51223317
124MP0002638_abnormal_pupillary_reflex0.51207957
125MP0005187_abnormal_penis_morphology0.49799978
126MP0001765_abnormal_ion_homeostasis0.48746839
127MP0005620_abnormal_muscle_contractility0.48634828
128MP0000015_abnormal_ear_pigmentation0.48450206
129MP0003956_abnormal_body_size0.46652011
130MP0001943_abnormal_respiration0.46156444

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.66263361
2Myokymia (HP:0002411)6.81264081
3Focal seizures (HP:0007359)6.16490803
4Visual hallucinations (HP:0002367)5.05027697
5Epileptic encephalopathy (HP:0200134)4.92356012
6Atonic seizures (HP:0010819)4.90420037
7Febrile seizures (HP:0002373)4.63634800
8Absence seizures (HP:0002121)4.57811690
9Hyperventilation (HP:0002883)4.53401466
10Dialeptic seizures (HP:0011146)4.46789655
11Generalized tonic-clonic seizures (HP:0002069)4.09755400
12Progressive cerebellar ataxia (HP:0002073)3.99255709
13Broad-based gait (HP:0002136)3.90823062
14Dysdiadochokinesis (HP:0002075)3.52481550
15Action tremor (HP:0002345)3.49194622
16Gaze-evoked nystagmus (HP:0000640)3.41073391
17Poor eye contact (HP:0000817)3.31336974
18Dysmetria (HP:0001310)3.20361380
19Truncal ataxia (HP:0002078)3.19239829
20Anxiety (HP:0000739)3.16823370
21Excessive salivation (HP:0003781)3.14389153
22Drooling (HP:0002307)3.14389153
23Amblyopia (HP:0000646)3.13618117
24Cerebral inclusion bodies (HP:0100314)3.06853734
25Abnormal social behavior (HP:0012433)2.97336190
26Impaired social interactions (HP:0000735)2.97336190
27Supranuclear gaze palsy (HP:0000605)2.91159522
28Impaired vibration sensation in the lower limbs (HP:0002166)2.87276586
29Primary atrial arrhythmia (HP:0001692)2.86855030
30Depression (HP:0000716)2.80976683
31Absent speech (HP:0001344)2.80478720
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.78278088
33Agitation (HP:0000713)2.77480363
34Epileptiform EEG discharges (HP:0011182)2.76345721
35B lymphocytopenia (HP:0010976)2.72037965
36Supraventricular tachycardia (HP:0004755)2.70571798
37Neurofibrillary tangles (HP:0002185)2.70013570
38Scanning speech (HP:0002168)2.69741420
39Urinary bladder sphincter dysfunction (HP:0002839)2.69338739
40Short tibia (HP:0005736)2.67722729
41Gait imbalance (HP:0002141)2.66596726
42Thyroiditis (HP:0100646)2.61558574
43Supraventricular arrhythmia (HP:0005115)2.61410372
44Abnormal eating behavior (HP:0100738)2.57780107
45Mutism (HP:0002300)2.54104250
46Stereotypic behavior (HP:0000733)2.53903985
47Insidious onset (HP:0003587)2.52210871
48Termporal pattern (HP:0011008)2.52210871
49EEG with generalized epileptiform discharges (HP:0011198)2.48381288
50Menstrual irregularities (HP:0000858)2.47014757
51Postural instability (HP:0002172)2.46814738
52Severe combined immunodeficiency (HP:0004430)2.46122981
53Torticollis (HP:0000473)2.45778966
54Atrial fibrillation (HP:0005110)2.45684870
55Impaired smooth pursuit (HP:0007772)2.44590870
56Protruding tongue (HP:0010808)2.42829879
57Bony spicule pigmentary retinopathy (HP:0007737)2.41870852
58Ankle clonus (HP:0011448)2.41762870
59Progressive inability to walk (HP:0002505)2.40681281
60Increased corneal curvature (HP:0100692)2.36354863
61Keratoconus (HP:0000563)2.36354863
62Absent/shortened dynein arms (HP:0200106)2.35675568
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.35675568
64Bundle branch block (HP:0011710)2.33237633
65Limb dystonia (HP:0002451)2.32733073
66Genetic anticipation (HP:0003743)2.29875674
67Dysmetric saccades (HP:0000641)2.29536505
68Vaginal atresia (HP:0000148)2.28805903
69Urinary urgency (HP:0000012)2.28581325
70Inability to walk (HP:0002540)2.26771212
71Abnormality of B cell number (HP:0010975)2.26525144
72Blue irides (HP:0000635)2.26358266
73Diplopia (HP:0000651)2.25711037
74Abnormality of binocular vision (HP:0011514)2.25711037
75Decreased circulating renin level (HP:0003351)2.25654025
76Hypoplasia of the thymus (HP:0000778)2.23530329
77Genital tract atresia (HP:0001827)2.23257275
78Hypsarrhythmia (HP:0002521)2.22360166
79Hemiparesis (HP:0001269)2.22014402
80Retinal dysplasia (HP:0007973)2.21062249
81Pheochromocytoma (HP:0002666)2.20518836
82Abnormality of the lower motor neuron (HP:0002366)2.20283058
83Hyperaldosteronism (HP:0000859)2.19383656
84Impulsivity (HP:0100710)2.19167077
85Bradykinesia (HP:0002067)2.18135439
86Focal dystonia (HP:0004373)2.16803636
87Status epilepticus (HP:0002133)2.15454253
88Papillary thyroid carcinoma (HP:0002895)2.15323289
89Abnormality of salivation (HP:0100755)2.14725386
90Spastic gait (HP:0002064)2.14268872
91Abnormality of the corticospinal tract (HP:0002492)2.13327007
92Congenital primary aphakia (HP:0007707)2.12568676
93Confusion (HP:0001289)2.11106501
94Generalized myoclonic seizures (HP:0002123)2.09671531
95Nephrogenic diabetes insipidus (HP:0009806)2.08805033
96Fetal akinesia sequence (HP:0001989)2.08296494
97Annular pancreas (HP:0001734)2.05857428
98Lower limb amyotrophy (HP:0007210)2.05589960
99Double outlet right ventricle (HP:0001719)2.04984816
100Congenital malformation of the right heart (HP:0011723)2.04984816
101Left ventricular hypertrophy (HP:0001712)2.04721656
102Bifid tongue (HP:0010297)2.03320771
103Abnormality of ocular smooth pursuit (HP:0000617)2.01583669
104Incomplete penetrance (HP:0003829)2.01153914
105Renal salt wasting (HP:0000127)2.01016540
106Delusions (HP:0000746)2.00782787
107Craniofacial dystonia (HP:0012179)2.00770539
108Hypoproteinemia (HP:0003075)2.00625730
109Widely spaced teeth (HP:0000687)1.99761361
110Poor coordination (HP:0002370)1.99218638
111Prolonged QT interval (HP:0001657)1.99114914
112Neuroendocrine neoplasm (HP:0100634)1.95730187
113Abnormal EKG (HP:0003115)1.94857422
114Type II lissencephaly (HP:0007260)1.94053219
115Aplasia/Hypoplasia of the lens (HP:0008063)1.93683890
116Impaired vibratory sensation (HP:0002495)1.93604701
117Combined immunodeficiency (HP:0005387)1.93322295
118Syncope (HP:0001279)1.92838320
119Aqueductal stenosis (HP:0002410)1.92602678
120Thickened helices (HP:0000391)1.92219275
121Intention tremor (HP:0002080)1.92157022
122Inappropriate behavior (HP:0000719)1.91434019
123Gait ataxia (HP:0002066)1.89855762
124Congenital sensorineural hearing impairment (HP:0008527)1.89273736
125Papilledema (HP:0001085)1.86229251
126Lower limb muscle weakness (HP:0007340)1.86100021
127Resting tremor (HP:0002322)1.85898447
128Psychosis (HP:0000709)1.85122636
129Sudden death (HP:0001699)1.84558575
130Oligodactyly (hands) (HP:0001180)1.84410460
131Midline defect of the nose (HP:0004122)1.83263883
132Esotropia (HP:0000565)1.82752253
133Fair hair (HP:0002286)1.79736979
134Broad metatarsal (HP:0001783)1.78936950
135Amyotrophic lateral sclerosis (HP:0007354)1.78897679
136Alacrima (HP:0000522)1.78728870
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77925110
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.77925110
139Polyphagia (HP:0002591)1.77211226
140Abnormal ciliary motility (HP:0012262)1.77182910
141Decreased central vision (HP:0007663)1.76312412
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75587617
143Generalized hypopigmentation of hair (HP:0011358)1.74547005
144Pendular nystagmus (HP:0012043)1.74508580
145Chronic otitis media (HP:0000389)1.73963513
146Ankyloglossia (HP:0010296)1.72968014
147Megalencephaly (HP:0001355)1.72919138
148Medial flaring of the eyebrow (HP:0010747)1.72504249
149Aplasia of the musculature (HP:0100854)1.68619270
150Abnormal drinking behavior (HP:0030082)1.68435420
151Polydipsia (HP:0001959)1.68435420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.63304418
2NTRK34.88160810
3RIPK43.45115683
4MAP3K93.15649812
5MAP3K42.78892202
6CASK2.56516827
7MINK12.51421585
8MAP2K72.38489586
9MARK12.26471817
10TNIK2.23965211
11DAPK21.97191391
12KSR21.96451240
13SIK21.86513808
14NTRK11.82019523
15KSR11.78772317
16PLK21.77587181
17ARAF1.77428036
18MAP3K131.70959313
19MAP2K41.67947669
20NTRK21.66851152
21EPHA31.64656195
22GRK51.62713979
23PAK61.58302335
24DAPK11.56507658
25MAP3K121.56205434
26FES1.53335756
27BMPR21.48542027
28PRPF4B1.46263585
29PNCK1.45926889
30CDK51.43358450
31FRK1.39925749
32INSRR1.34420503
33MAPK131.34055435
34SIK31.31989185
35CAMK2A1.29596697
36CAMKK11.28494972
37NME11.26624131
38DYRK21.24089965
39CAMK2B1.23076603
40PRKD31.20819507
41PTK2B1.17137474
42PRKCG1.16507163
43CAMKK21.10918818
44MAP3K20.98387241
45RAF10.98249803
46STK380.94327637
47CDK190.91246635
48STK390.88780121
49OBSCN0.87724668
50FGR0.86144584
51UHMK10.84120238
52WNK40.82756589
53CAMK10.81740984
54SGK4940.81257726
55SGK2230.81257726
56CDK140.76972530
57MARK20.76811066
58CDK180.76739313
59SGK10.76064807
60SGK20.74623826
61TAF10.73751363
62AKT30.73677280
63MAPK40.73500278
64ALK0.72789775
65CAMK2D0.72374742
66CDK150.70887858
67OXSR10.68878822
68DYRK1A0.66196476
69MAP4K20.64675756
70DDR20.64396203
71FER0.63964130
72CSNK1G20.63826850
73PRKCE0.62815854
74CDK11A0.62642624
75LATS20.62530579
76STK110.62321292
77NLK0.60031738
78PINK10.59800246
79PAK30.59497949
80RET0.59344206
81MAP3K70.59085824
82BRAF0.58991198
83TNK20.56326273
84PHKG20.55472672
85PHKG10.55472672
86PDPK10.55200502
87BCR0.52545358
88CAMK2G0.51781588
89MAP3K60.51056644
90PDK10.50794080
91TYRO30.50104375
92MKNK20.49993295
93GRK70.49868664
94NEK60.48550127
95FGFR20.48255553
96ZAK0.46992891
97DMPK0.46872279
98TAOK10.46554194
99PRKCZ0.46306058
100GRK10.45851672
101PRKCH0.45636164
102MAPK100.43694684
103FYN0.42704490
104RPS6KA30.42586064
105SGK30.42327581
106PKN10.42166569
107MAP3K10.41617503
108ADRBK20.41326428
109MAP2K10.40323508
110MUSK0.40004669
111TRIM280.39404702
112EPHB20.38806684
113GRK60.37414605
114* PRKACA0.36801941
115WNK30.35179912
116TLK10.35060049
117ROCK20.34694081
118PRKG10.34337380
119PRKCB0.34277181
120CSNK1E0.33971691
121PRKCQ0.33000415
122CAMK40.31568659
123PRKCA0.31088808
124GSK3B0.30578881
125ROCK10.30397603
126PRKACB0.25714589
127WNK10.24510426
128PRKACG0.22860363
129MAPK80.22751714
130MAP2K60.21811111

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25386056
2Long-term potentiation_Homo sapiens_hsa047202.95914819
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.95331754
4Morphine addiction_Homo sapiens_hsa050322.86209464
5Circadian entrainment_Homo sapiens_hsa047132.81046496
6GABAergic synapse_Homo sapiens_hsa047272.79727398
7Synaptic vesicle cycle_Homo sapiens_hsa047212.77996994
8Glutamatergic synapse_Homo sapiens_hsa047242.74520789
9Amphetamine addiction_Homo sapiens_hsa050312.73774470
10Olfactory transduction_Homo sapiens_hsa047402.67264761
11Dopaminergic synapse_Homo sapiens_hsa047282.36707834
12Taste transduction_Homo sapiens_hsa047422.20350087
13Salivary secretion_Homo sapiens_hsa049702.20311076
14Serotonergic synapse_Homo sapiens_hsa047262.11710598
15Regulation of autophagy_Homo sapiens_hsa041402.08945579
16Renin secretion_Homo sapiens_hsa049241.96434696
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94011783
18Protein export_Homo sapiens_hsa030601.93506875
19Cocaine addiction_Homo sapiens_hsa050301.91295235
20Cholinergic synapse_Homo sapiens_hsa047251.91190409
21Calcium signaling pathway_Homo sapiens_hsa040201.90286966
22Long-term depression_Homo sapiens_hsa047301.80833991
23Insulin secretion_Homo sapiens_hsa049111.80275715
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75406180
25Oxytocin signaling pathway_Homo sapiens_hsa049211.71459097
26Gastric acid secretion_Homo sapiens_hsa049711.66804657
27Collecting duct acid secretion_Homo sapiens_hsa049661.58353132
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55870929
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47312456
30GnRH signaling pathway_Homo sapiens_hsa049121.41209372
31Gap junction_Homo sapiens_hsa045401.38738598
32cAMP signaling pathway_Homo sapiens_hsa040241.38724302
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22389013
34Phototransduction_Homo sapiens_hsa047441.19282856
35Axon guidance_Homo sapiens_hsa043601.16616461
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16218837
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13895519
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09146595
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08950473
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07704886
41Cardiac muscle contraction_Homo sapiens_hsa042601.07367098
42Estrogen signaling pathway_Homo sapiens_hsa049151.05753573
43Ether lipid metabolism_Homo sapiens_hsa005651.00034907
44Glioma_Homo sapiens_hsa052140.97940653
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.97197381
46Melanogenesis_Homo sapiens_hsa049160.95645378
47Type II diabetes mellitus_Homo sapiens_hsa049300.93906674
48ErbB signaling pathway_Homo sapiens_hsa040120.90364917
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89481503
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89441027
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88207069
52Linoleic acid metabolism_Homo sapiens_hsa005910.87664226
53Vibrio cholerae infection_Homo sapiens_hsa051100.87658144
54Pancreatic secretion_Homo sapiens_hsa049720.84766606
55Selenocompound metabolism_Homo sapiens_hsa004500.83380078
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81304305
57Choline metabolism in cancer_Homo sapiens_hsa052310.81167598
58Oocyte meiosis_Homo sapiens_hsa041140.79586138
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.78157998
60Alzheimers disease_Homo sapiens_hsa050100.75895835
61Dorso-ventral axis formation_Homo sapiens_hsa043200.75610946
62Dilated cardiomyopathy_Homo sapiens_hsa054140.74783388
63Thyroid hormone synthesis_Homo sapiens_hsa049180.73046445
64Sulfur relay system_Homo sapiens_hsa041220.69366375
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68138187
66MAPK signaling pathway_Homo sapiens_hsa040100.64282584
67VEGF signaling pathway_Homo sapiens_hsa043700.63667057
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63245144
69African trypanosomiasis_Homo sapiens_hsa051430.60014984
70Ras signaling pathway_Homo sapiens_hsa040140.59132777
71Glucagon signaling pathway_Homo sapiens_hsa049220.57764617
72Oxidative phosphorylation_Homo sapiens_hsa001900.56341667
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54925371
74Rap1 signaling pathway_Homo sapiens_hsa040150.54733824
75Alcoholism_Homo sapiens_hsa050340.54284908
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.54051503
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54015642
78Circadian rhythm_Homo sapiens_hsa047100.53279829
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49425799
80Vitamin digestion and absorption_Homo sapiens_hsa049770.48797146
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48377899
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.45285774
83Tight junction_Homo sapiens_hsa045300.45255371
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44036381
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43924120
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43270687
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.42874346
88Parkinsons disease_Homo sapiens_hsa050120.42275623
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.42237214
90Inositol phosphate metabolism_Homo sapiens_hsa005620.41913479
91ABC transporters_Homo sapiens_hsa020100.39828158
92Folate biosynthesis_Homo sapiens_hsa007900.39107358
93Non-small cell lung cancer_Homo sapiens_hsa052230.38501285
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38408070
95Hippo signaling pathway_Homo sapiens_hsa043900.37988325
96Ovarian steroidogenesis_Homo sapiens_hsa049130.37917590
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37866028
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36895219
99Prion diseases_Homo sapiens_hsa050200.36351269
100Wnt signaling pathway_Homo sapiens_hsa043100.36296968
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35843288
102mTOR signaling pathway_Homo sapiens_hsa041500.34195755
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33396728
104Type I diabetes mellitus_Homo sapiens_hsa049400.32740716
105Bile secretion_Homo sapiens_hsa049760.31755467
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30848347
107Glycerolipid metabolism_Homo sapiens_hsa005610.28534553
108Insulin signaling pathway_Homo sapiens_hsa049100.27569793
109Renal cell carcinoma_Homo sapiens_hsa052110.27504039
110Rheumatoid arthritis_Homo sapiens_hsa053230.27225039
111Butanoate metabolism_Homo sapiens_hsa006500.26850500
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26456680
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26005696
114Chemokine signaling pathway_Homo sapiens_hsa040620.25478360
115Huntingtons disease_Homo sapiens_hsa050160.25346567
116Hedgehog signaling pathway_Homo sapiens_hsa043400.25174589
117Basal transcription factors_Homo sapiens_hsa030220.24557718
118Prolactin signaling pathway_Homo sapiens_hsa049170.24526790
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24049399
120Mineral absorption_Homo sapiens_hsa049780.23801790
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22817121
122Tryptophan metabolism_Homo sapiens_hsa003800.22609537
123Protein digestion and absorption_Homo sapiens_hsa049740.20864464
124Lysine degradation_Homo sapiens_hsa003100.17552086

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