KCNA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.70474528
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.64943668
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20859502
4synaptic vesicle exocytosis (GO:0016079)5.06553266
5locomotory exploration behavior (GO:0035641)5.02124411
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94268823
7glutamate secretion (GO:0014047)4.90729522
8vocalization behavior (GO:0071625)4.82571767
9regulation of synaptic vesicle exocytosis (GO:2000300)4.80445827
10thalamus development (GO:0021794)4.72792209
11neuron cell-cell adhesion (GO:0007158)4.63892057
12neuronal action potential propagation (GO:0019227)4.61040332
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.54036716
14protein localization to synapse (GO:0035418)4.31425735
15layer formation in cerebral cortex (GO:0021819)4.20810692
16generation of neurons (GO:0048699)4.19730782
17regulation of synaptic vesicle transport (GO:1902803)4.15966686
18central nervous system myelination (GO:0022010)4.15600836
19axon ensheathment in central nervous system (GO:0032291)4.15600836
20regulation of glutamate receptor signaling pathway (GO:1900449)4.12785772
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.09512327
22cilium movement (GO:0003341)4.08409016
23cilium or flagellum-dependent cell motility (GO:0001539)4.08376425
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.08024784
25positive regulation of dendritic spine morphogenesis (GO:0061003)4.07685462
26gamma-aminobutyric acid transport (GO:0015812)4.07065683
27neurotransmitter secretion (GO:0007269)4.05493170
28regulation of neuronal synaptic plasticity (GO:0048168)3.95978967
29exploration behavior (GO:0035640)3.94403359
30pyrimidine nucleobase catabolic process (GO:0006208)3.85255750
31urinary tract smooth muscle contraction (GO:0014848)3.82027179
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.81237838
33cellular potassium ion homeostasis (GO:0030007)3.80435459
34cellular response to cholesterol (GO:0071397)3.76960330
35synaptic transmission, glutamatergic (GO:0035249)3.75947857
36regulation of synapse structural plasticity (GO:0051823)3.73463288
37glutamate receptor signaling pathway (GO:0007215)3.66859275
38ribosomal small subunit assembly (GO:0000028)3.65684850
39neuron-neuron synaptic transmission (GO:0007270)3.63518458
40proline transport (GO:0015824)3.61467088
41neurotransmitter-gated ion channel clustering (GO:0072578)3.60141512
42glycine transport (GO:0015816)3.59984372
43dendritic spine morphogenesis (GO:0060997)3.58635339
44sodium ion export (GO:0071436)3.58330310
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58081858
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.57797681
47short-term memory (GO:0007614)3.57089879
48regulation of histone H3-K9 methylation (GO:0051570)3.54123002
49motile cilium assembly (GO:0044458)3.53420975
50neuron recognition (GO:0008038)3.51582304
51transmission of nerve impulse (GO:0019226)3.50990723
52retina layer formation (GO:0010842)3.49954528
53presynaptic membrane organization (GO:0097090)3.49776237
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48356392
55neurotransmitter transport (GO:0006836)3.48176333
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46844703
57genitalia morphogenesis (GO:0035112)3.45843699
58axonemal dynein complex assembly (GO:0070286)3.45639567
59positive regulation of dendritic spine development (GO:0060999)3.42872879
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41992539
61positive regulation of membrane potential (GO:0045838)3.41480795
62L-amino acid import (GO:0043092)3.40770339
63cellular response to sterol (GO:0036315)3.40030038
64presynaptic membrane assembly (GO:0097105)3.39725513
65long-term memory (GO:0007616)3.39660135
66histone H2A acetylation (GO:0043968)3.36858123
67nucleobase catabolic process (GO:0046113)3.35437362
68cerebellar Purkinje cell differentiation (GO:0021702)3.34315444
69dendrite morphogenesis (GO:0048813)3.32735874
70regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31024327
71adult walking behavior (GO:0007628)3.29327094
72postsynaptic membrane organization (GO:0001941)3.27054671
73establishment of mitotic spindle orientation (GO:0000132)3.26740270
74neuromuscular process controlling posture (GO:0050884)3.26224186
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26193269
76positive regulation of synapse assembly (GO:0051965)3.26040067
77central nervous system projection neuron axonogenesis (GO:0021952)3.25643049
78epithelial cilium movement (GO:0003351)3.25544784
79neuronal ion channel clustering (GO:0045161)3.24826372
80regulation of neurotransmitter secretion (GO:0046928)3.24595983
81neuromuscular process controlling balance (GO:0050885)3.24235756
82establishment of spindle orientation (GO:0051294)3.22210973
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.19979069
84positive regulation of protein export from nucleus (GO:0046827)3.19668360
85synaptic vesicle endocytosis (GO:0048488)3.19458121
86activation of protein kinase A activity (GO:0034199)3.19046257
87regulation of synaptic plasticity (GO:0048167)3.18384484
88forebrain neuron development (GO:0021884)3.17480928
89regulation of postsynaptic membrane potential (GO:0060078)3.17267249
90cell migration in hindbrain (GO:0021535)3.16591755
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15265109
92cerebellum development (GO:0021549)3.15045827
93auditory behavior (GO:0031223)3.14942323
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.13941950
95regulation of neurotransmitter levels (GO:0001505)3.13912702
96membrane hyperpolarization (GO:0060081)3.12079727
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10932416
98single strand break repair (GO:0000012)3.08773031
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08431236
100regulation of dendritic spine morphogenesis (GO:0061001)3.08170978
101cerebellar granule cell differentiation (GO:0021707)3.08040862
102axonal fasciculation (GO:0007413)3.08017930
103membrane depolarization during action potential (GO:0086010)3.06137167
104regulation of neurotransmitter transport (GO:0051588)3.05370928
105prepulse inhibition (GO:0060134)3.04008359
106long-term synaptic potentiation (GO:0060291)3.04003585
107cytoplasmic mRNA processing body assembly (GO:0033962)3.03577675
108negative regulation of neurotransmitter secretion (GO:0046929)3.03245917
109negative regulation of Rho protein signal transduction (GO:0035024)3.02264025
110response to auditory stimulus (GO:0010996)3.00670478
111establishment of mitotic spindle localization (GO:0040001)2.99367093
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99119973
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98887485
114synapse assembly (GO:0007416)2.97630015
115calcium ion import (GO:0070509)2.97371509
116establishment of spindle localization (GO:0051293)2.95982837
117positive regulation of synapse maturation (GO:0090129)2.93810219
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.93574128
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93574128
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93182793
121mating behavior (GO:0007617)2.92508416
122regulation of voltage-gated calcium channel activity (GO:1901385)2.92123561
123vesicle transport along microtubule (GO:0047496)2.92088445
124establishment of mitochondrion localization (GO:0051654)2.91912132
125membrane depolarization (GO:0051899)2.90705107
126nerve growth factor signaling pathway (GO:0038180)2.89667155
127cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88887065
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87372427
129potassium ion import (GO:0010107)2.86079625
130behavioral response to cocaine (GO:0048148)2.85301406
131potassium ion homeostasis (GO:0055075)2.84784567
132organelle transport along microtubule (GO:0072384)2.84698304
133learning (GO:0007612)2.84647972
134regulation of ARF protein signal transduction (GO:0032012)2.84027493
135regulation of vesicle fusion (GO:0031338)2.83870214
136spinal cord motor neuron differentiation (GO:0021522)2.83619967
137neuromuscular process (GO:0050905)2.83196060
138heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.81368848
139positive regulation of potassium ion transmembrane transport (GO:1901381)2.80245071
140regulation of synaptic transmission (GO:0050804)2.79877537
141neuron fate determination (GO:0048664)2.79211786
142attachment of spindle microtubules to kinetochore (GO:0008608)2.78598075
143regulation of oligodendrocyte differentiation (GO:0048713)2.78475335
144protein localization to cilium (GO:0061512)2.76397912
145negative regulation of neurotransmitter transport (GO:0051589)2.76275339
146axon cargo transport (GO:0008088)2.76010504
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75960980
148neurogenesis (GO:0022008)2.71710511
149ventricular system development (GO:0021591)2.69632283
150neural tube formation (GO:0001841)2.68493237
151regulation of centrosome duplication (GO:0010824)2.67821102
152centriole assembly (GO:0098534)2.67373505
153positive regulation of dendrite morphogenesis (GO:0050775)2.67096584
154regulation of cilium movement (GO:0003352)2.65811163
155intra-S DNA damage checkpoint (GO:0031573)2.64972668
156neuronal stem cell maintenance (GO:0097150)2.64587914
157cellular sodium ion homeostasis (GO:0006883)2.64059952
158microtubule depolymerization (GO:0007019)2.62870397
159protein localization to cytoskeleton (GO:0044380)2.62833661
160positive regulation of neurotransmitter secretion (GO:0001956)2.62409062
161G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62150942
162mitotic sister chromatid cohesion (GO:0007064)2.60492801
163mechanosensory behavior (GO:0007638)2.60102996
164epithelial cell differentiation involved in kidney development (GO:0035850)2.59619227
165regulation of centriole replication (GO:0046599)2.59068762
166central nervous system neuron axonogenesis (GO:0021955)2.55108950
167cAMP catabolic process (GO:0006198)2.52527052
168establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51495799
169mitochondrion transport along microtubule (GO:0047497)2.51495799
170pre-miRNA processing (GO:0031054)2.51328503
171microtubule anchoring (GO:0034453)2.49164591
172protein localization to microtubule (GO:0035372)2.49116386

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.26462767
2EZH2_22144423_ChIP-Seq_EOC_Human5.19094657
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.72734877
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.61042796
5GBX2_23144817_ChIP-Seq_PC3_Human3.44024515
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07907641
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01246203
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95902489
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72410348
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72410348
11FUS_26573619_Chip-Seq_HEK293_Human2.69570451
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59705367
13REST_21632747_ChIP-Seq_MESCs_Mouse2.54541507
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53073886
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52700760
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52380071
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.51209819
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50097968
19DROSHA_22980978_ChIP-Seq_HELA_Human2.49640494
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46605859
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44754424
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.42377689
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.33798886
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.28841095
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27681776
26* EED_16625203_ChIP-ChIP_MESCs_Mouse2.23916070
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21001975
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.21001975
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17686981
30E2F7_22180533_ChIP-Seq_HELA_Human2.16247892
31* RNF2_27304074_Chip-Seq_ESCs_Mouse2.12917016
32AR_21572438_ChIP-Seq_LNCaP_Human2.12900693
33REST_18959480_ChIP-ChIP_MESCs_Mouse2.11967180
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95743249
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94413486
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88737627
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86686137
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83339114
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80769507
40TAF15_26573619_Chip-Seq_HEK293_Human1.73808556
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71347045
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67218123
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66517821
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.65727623
45CBP_20019798_ChIP-Seq_JUKART_Human1.64922883
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64922883
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54577863
48SMAD4_21799915_ChIP-Seq_A2780_Human1.53353623
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51735545
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49383249
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.48901087
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47227373
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47110022
54* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45929482
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45312029
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42514272
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42339334
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40958823
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40304494
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.40295753
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.39213130
62EWS_26573619_Chip-Seq_HEK293_Human1.37914076
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37544773
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36790844
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36681815
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36668647
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33718777
68* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33581247
69* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29631800
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29596230
71P300_19829295_ChIP-Seq_ESCs_Human1.29477244
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27502721
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.26054111
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24288484
75SOX9_26525672_Chip-Seq_HEART_Mouse1.23826210
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23799897
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.23256275
78STAT3_23295773_ChIP-Seq_U87_Human1.21161996
79ZNF274_21170338_ChIP-Seq_K562_Hela1.20289333
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19458451
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18809265
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18586053
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17852027
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17243624
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.16133040
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15166176
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13983474
88AR_19668381_ChIP-Seq_PC3_Human1.13306808
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12694958
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12241970
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.11320344
92AR_25329375_ChIP-Seq_VCAP_Human1.11073461
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11020259
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.10596224
95BCAT_22108803_ChIP-Seq_LS180_Human1.10293851
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09032627
97AHR_22903824_ChIP-Seq_MCF-7_Human1.07513974
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.07275365
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06711314
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06464488
101RNF2_27304074_Chip-Seq_NSC_Mouse1.03984520
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03618872
103KDM2B_26808549_Chip-Seq_K562_Human1.03326532
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02688608
105* TCF4_23295773_ChIP-Seq_U87_Human1.02355164
106* RUNX_20019798_ChIP-Seq_JUKART_Human1.01878647
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.01731106
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00710616
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00448243
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00163629
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99905009
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98868663
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98579513
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98319351
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97664215
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.96389968
117TP53_16413492_ChIP-PET_HCT116_Human0.96308568
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.95412905
119SMAD3_21741376_ChIP-Seq_ESCs_Human0.95260408
120GF1B_26923725_Chip-Seq_HPCs_Mouse0.93972481
121IGF1R_20145208_ChIP-Seq_DFB_Human0.93655156
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.93500162
123ER_23166858_ChIP-Seq_MCF-7_Human0.93067628
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92252672
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.91808897
126RUNX2_22187159_ChIP-Seq_PCA_Human0.91744132
127* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90438824
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90324017
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89648484
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89542845
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89182274
132TP53_22573176_ChIP-Seq_HFKS_Human0.88904840
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86607589
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86409882
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.85225927
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.85102713
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84584253
138* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84293761
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83933418
140CTCF_27219007_Chip-Seq_Bcells_Human0.82122115
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80676249
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80613108
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.80076539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75846490
2MP0003880_abnormal_central_pattern4.71071644
3MP0004270_analgesia4.04524938
4MP0008057_abnormal_DNA_replication3.99392288
5MP0006292_abnormal_olfactory_placode3.86795208
6MP0003635_abnormal_synaptic_transmissio3.85508955
7MP0009046_muscle_twitch3.20128369
8MP0002064_seizures3.17707283
9MP0009745_abnormal_behavioral_response3.15563875
10MP0001968_abnormal_touch/_nociception3.14009658
11MP0005423_abnormal_somatic_nervous3.04439207
12MP0002063_abnormal_learning/memory/cond2.95852070
13MP0002734_abnormal_mechanical_nocicepti2.92799414
14MP0002653_abnormal_ependyma_morphology2.88845099
15MP0002272_abnormal_nervous_system2.84691601
16MP0001486_abnormal_startle_reflex2.67294213
17MP0002572_abnormal_emotion/affect_behav2.56841969
18MP0002735_abnormal_chemical_nociception2.43748356
19MP0002736_abnormal_nociception_after2.36073798
20MP0002822_catalepsy2.15653443
21* MP0002733_abnormal_thermal_nociception2.14499089
22MP0003329_amyloid_beta_deposits2.11774609
23* MP0001970_abnormal_pain_threshold2.09347189
24MP0000920_abnormal_myelination2.04938435
25MP0002067_abnormal_sensory_capabilities2.03765397
26MP0008569_lethality_at_weaning2.03398041
27MP0000778_abnormal_nervous_system2.01137285
28MP0001440_abnormal_grooming_behavior1.93526738
29MP0004858_abnormal_nervous_system1.92824767
30MP0001501_abnormal_sleep_pattern1.91724056
31MP0002638_abnormal_pupillary_reflex1.87385687
32MP0002184_abnormal_innervation1.83790054
33MP0000955_abnormal_spinal_cord1.77407427
34MP0004885_abnormal_endolymph1.75978510
35MP0004811_abnormal_neuron_physiology1.75562935
36MP0005386_behavior/neurological_phenoty1.70556086
37MP0004924_abnormal_behavior1.70556086
38MP0009780_abnormal_chondrocyte_physiolo1.70545169
39MP0004142_abnormal_muscle_tone1.66879912
40MP0004510_myositis1.66696805
41MP0006276_abnormal_autonomic_nervous1.65178928
42MP0002009_preneoplasia1.60814043
43MP0002557_abnormal_social/conspecific_i1.58789764
44MP0002882_abnormal_neuron_morphology1.57631478
45MP0001529_abnormal_vocalization1.50356824
46MP0002066_abnormal_motor_capabilities/c1.50256128
47MP0005646_abnormal_pituitary_gland1.49148073
48MP0010386_abnormal_urinary_bladder1.48579210
49MP0001984_abnormal_olfaction1.48101195
50MP0003121_genomic_imprinting1.47850981
51MP0003633_abnormal_nervous_system1.42340700
52MP0003690_abnormal_glial_cell1.41247137
53MP0003634_abnormal_glial_cell1.41180643
54MP0001873_stomach_inflammation1.40915006
55MP0001905_abnormal_dopamine_level1.40393808
56MP0003631_nervous_system_phenotype1.33115674
57MP0002229_neurodegeneration1.31355443
58MP0004742_abnormal_vestibular_system1.31244482
59MP0005645_abnormal_hypothalamus_physiol1.29509432
60MP0003938_abnormal_ear_development1.27371914
61MP0002396_abnormal_hematopoietic_system1.26825471
62MP0008877_abnormal_DNA_methylation1.26547864
63MP0002909_abnormal_adrenal_gland1.21936897
64MP0003632_abnormal_nervous_system1.20860644
65MP0001502_abnormal_circadian_rhythm1.19611069
66MP0003879_abnormal_hair_cell1.18752597
67MP0005551_abnormal_eye_electrophysiolog1.16638174
68MP0003122_maternal_imprinting1.14552473
69MP0006035_abnormal_mitochondrial_morpho1.14439770
70MP0000026_abnormal_inner_ear1.13066426
71MP0000383_abnormal_hair_follicle1.12020249
72MP0002152_abnormal_brain_morphology1.10788516
73MP0001346_abnormal_lacrimal_gland1.10322428
74MP0003787_abnormal_imprinting1.09786878
75MP0004145_abnormal_muscle_electrophysio1.09684062
76MP0000751_myopathy1.09057771
77MP0002102_abnormal_ear_morphology1.05590565
78MP0003077_abnormal_cell_cycle1.02875884
79MP0001286_abnormal_eye_development1.00517560
80MP0002127_abnormal_cardiovascular_syste0.98558166
81MP0005171_absent_coat_pigmentation0.96596951
82MP0002752_abnormal_somatic_nervous0.96324695
83MP0001177_atelectasis0.96131189
84MP0000604_amyloidosis0.94501636
85MP0001299_abnormal_eye_distance/0.93813682
86MP0001963_abnormal_hearing_physiology0.92516214
87MP0008058_abnormal_DNA_repair0.91751189
88MP0005310_abnormal_salivary_gland0.91583340
89MP0009697_abnormal_copulation0.91542146
90MP0001485_abnormal_pinna_reflex0.90248387
91MP0003890_abnormal_embryonic-extraembry0.89958378
92MP0005623_abnormal_meninges_morphology0.89910483
93MP0005266_abnormal_metabolism0.89514960
94MP0004808_abnormal_hematopoietic_stem0.87955201
95MP0002069_abnormal_eating/drinking_beha0.84124343
96MP0003698_abnormal_male_reproductive0.84026782
97MP0002405_respiratory_system_inflammati0.83669193
98MP0001188_hyperpigmentation0.83519393
99MP0003937_abnormal_limbs/digits/tail_de0.83215851
100MP0000013_abnormal_adipose_tissue0.82126853
101MP0008961_abnormal_basal_metabolism0.81917525
102MP0008874_decreased_physiological_sensi0.81449879
103MP0003935_abnormal_craniofacial_develop0.78802262
104MP0000747_muscle_weakness0.78785638
105MP0004043_abnormal_pH_regulation0.77830596
106MP0008872_abnormal_physiological_respon0.77013709
107MP0000049_abnormal_middle_ear0.76775833
108MP0005409_darkened_coat_color0.76502522
109MP0000703_abnormal_thymus_morphology0.76215142
110MP0002090_abnormal_vision0.75740907
111MP0002083_premature_death0.75447740
112MP0004085_abnormal_heartbeat0.73364727
113MP0010094_abnormal_chromosome_stability0.72672628
114MP0003283_abnormal_digestive_organ0.70160363
115MP0003137_abnormal_impulse_conducting0.69707632
116MP0003868_abnormal_feces_composition0.69601727
117MP0000631_abnormal_neuroendocrine_gland0.68240130
118MP0002332_abnormal_exercise_endurance0.66885173
119MP0001348_abnormal_lacrimal_gland0.66134822
120MP0005499_abnormal_olfactory_system0.65668061
121MP0005394_taste/olfaction_phenotype0.65668061
122MP0003075_altered_response_to0.65467762
123MP0003763_abnormal_thymus_physiology0.65175219
124MP0001943_abnormal_respiration0.63575909
125MP0002081_perinatal_lethality0.61914937
126MP0001929_abnormal_gametogenesis0.61832738
127MP0005535_abnormal_body_temperature0.61634513
128MP0004233_abnormal_muscle_weight0.61186154
129MP0000569_abnormal_digit_pigmentation0.60509129
130MP0003861_abnormal_nervous_system0.57718265
131MP0001664_abnormal_digestion0.56988156
132MP0010769_abnormal_survival0.55082404
133MP0003172_abnormal_lysosome_physiology0.54872787
134MP0005410_abnormal_fertilization0.54119391
135MP0010770_preweaning_lethality0.53534924
136MP0002082_postnatal_lethality0.53534924
137MP0006072_abnormal_retinal_apoptosis0.52995292
138MP0010768_mortality/aging0.50976725
139MP0002751_abnormal_autonomic_nervous0.50702870
140MP0005253_abnormal_eye_physiology0.48177257

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.83792308
2Myokymia (HP:0002411)6.72956970
3Focal motor seizures (HP:0011153)6.20052269
4Focal seizures (HP:0007359)5.01444733
5Abnormal respiratory motile cilium physiology (HP:0012261)4.77756542
6Action tremor (HP:0002345)4.76346680
7Chronic bronchitis (HP:0004469)4.33693928
8Visual hallucinations (HP:0002367)4.24482238
9Rhinitis (HP:0012384)4.23470322
10Epileptic encephalopathy (HP:0200134)4.20133327
11Ankle clonus (HP:0011448)4.14957546
12Supranuclear gaze palsy (HP:0000605)4.14740501
13Atonic seizures (HP:0010819)4.07079061
14Progressive cerebellar ataxia (HP:0002073)4.03191035
15Abnormal ciliary motility (HP:0012262)3.79061974
16Peripheral hypomyelination (HP:0007182)3.65653946
17Termporal pattern (HP:0011008)3.63669699
18Insidious onset (HP:0003587)3.63669699
19Febrile seizures (HP:0002373)3.61005807
20Medulloblastoma (HP:0002885)3.60576849
21Colon cancer (HP:0003003)3.55737071
22Neurofibrillary tangles (HP:0002185)3.51355759
23Abnormality of the corticospinal tract (HP:0002492)3.46243389
24Absence seizures (HP:0002121)3.42476906
25Recurrent sinusitis (HP:0011108)3.41509356
26Dysmetric saccades (HP:0000641)3.37989717
27Dysmetria (HP:0001310)3.33356908
28Dialeptic seizures (HP:0011146)3.28227479
29Generalized tonic-clonic seizures (HP:0002069)3.27429960
30Spastic gait (HP:0002064)3.25018273
31Broad-based gait (HP:0002136)3.13355888
32Gaze-evoked nystagmus (HP:0000640)3.03935768
33Mutism (HP:0002300)3.03226702
34Pheochromocytoma (HP:0002666)3.02685248
35Urinary bladder sphincter dysfunction (HP:0002839)3.01527282
36Dysdiadochokinesis (HP:0002075)2.99434896
37Dynein arm defect of respiratory motile cilia (HP:0012255)2.97231360
38Absent/shortened dynein arms (HP:0200106)2.97231360
39Depression (HP:0000716)2.95706348
40Cerebral inclusion bodies (HP:0100314)2.94818648
41Recurrent otitis media (HP:0000403)2.91714153
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.91594982
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.91594982
44Postural instability (HP:0002172)2.90882220
45Impaired vibration sensation in the lower limbs (HP:0002166)2.89752169
46IgM deficiency (HP:0002850)2.89610266
47Intention tremor (HP:0002080)2.87846386
48Abnormal eating behavior (HP:0100738)2.86420116
49Pancreatic cysts (HP:0001737)2.84019184
50Urinary urgency (HP:0000012)2.82909071
51Truncal ataxia (HP:0002078)2.81929538
52Cerebellar dysplasia (HP:0007033)2.81668784
53Scanning speech (HP:0002168)2.81566841
54Limb dystonia (HP:0002451)2.79831060
55Nephronophthisis (HP:0000090)2.72112335
56Anxiety (HP:0000739)2.70836229
57Onion bulb formation (HP:0003383)2.70496000
58Volvulus (HP:0002580)2.67217903
59Torticollis (HP:0000473)2.66689275
60Poor eye contact (HP:0000817)2.66353482
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65907729
62Short 4th metacarpal (HP:0010044)2.65907729
63Megalencephaly (HP:0001355)2.61433632
64Hyperventilation (HP:0002883)2.60787265
65Progressive inability to walk (HP:0002505)2.60004366
66Heterotopia (HP:0002282)2.59185350
67Abnormal number of erythroid precursors (HP:0012131)2.56289865
68Lower limb muscle weakness (HP:0007340)2.55847277
69Chronic hepatic failure (HP:0100626)2.55500699
70Neuroendocrine neoplasm (HP:0100634)2.54470579
71Akinesia (HP:0002304)2.53886046
72Abnormality of cells of the erythroid lineage (HP:0012130)2.52611422
73Neoplasm of striated muscle (HP:0009728)2.51135924
74Abnormality of the renal cortex (HP:0011035)2.50176559
75Acute lymphatic leukemia (HP:0006721)2.49103646
76Impaired social interactions (HP:0000735)2.47028953
77Abnormal social behavior (HP:0012433)2.47028953
78True hermaphroditism (HP:0010459)2.46896186
79Papillary thyroid carcinoma (HP:0002895)2.46839208
80Abnormality of binocular vision (HP:0011514)2.46044270
81Diplopia (HP:0000651)2.46044270
82Bronchitis (HP:0012387)2.44261623
83Ulnar claw (HP:0001178)2.40534938
84Genetic anticipation (HP:0003743)2.40206404
85Focal dystonia (HP:0004373)2.38254920
86Neoplasm of the heart (HP:0100544)2.37354989
87Papilledema (HP:0001085)2.36425324
88Submucous cleft hard palate (HP:0000176)2.34534838
89Supernumerary bones of the axial skeleton (HP:0009144)2.34199709
90Bronchiectasis (HP:0002110)2.33690787
91Hemiparesis (HP:0001269)2.33043247
92Rhabdomyosarcoma (HP:0002859)2.28505438
93Drooling (HP:0002307)2.27658781
94Excessive salivation (HP:0003781)2.27658781
95Molar tooth sign on MRI (HP:0002419)2.27483801
96Abnormality of midbrain morphology (HP:0002418)2.27483801
97Supernumerary ribs (HP:0005815)2.24584174
98Craniofacial dystonia (HP:0012179)2.21352117
99Bradykinesia (HP:0002067)2.20490089
100Hammertoe (HP:0001765)2.18529465
101Clonus (HP:0002169)2.18269211
102Abnormality of the parietal bone (HP:0002696)2.17798156
103Neoplasm of the oral cavity (HP:0100649)2.17093398
104Abnormality of the renal medulla (HP:0100957)2.16644504
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.15044818
106Hemiplegia (HP:0002301)2.12874526
107Tubular atrophy (HP:0000092)2.12128991
108Amblyopia (HP:0000646)2.11875760
109Postural tremor (HP:0002174)2.10208716
110Fetal akinesia sequence (HP:0001989)2.08615890
111Neuronal loss in central nervous system (HP:0002529)2.07669667
112Abnormal drinking behavior (HP:0030082)2.05302917
113Polydipsia (HP:0001959)2.05302917
114Polyphagia (HP:0002591)2.05055646
115Abnormality of the lower motor neuron (HP:0002366)2.02803263
116Nasal polyposis (HP:0100582)2.02261869
117Smooth philtrum (HP:0000319)2.01223467
118Epileptiform EEG discharges (HP:0011182)1.98744309
119Bony spicule pigmentary retinopathy (HP:0007737)1.98136719
120Impaired smooth pursuit (HP:0007772)1.97746710
121Absent speech (HP:0001344)1.97645906
122Decreased motor nerve conduction velocity (HP:0003431)1.96430940
123Medial flaring of the eyebrow (HP:0010747)1.96190267
124EEG with generalized epileptiform discharges (HP:0011198)1.96149737
125Generalized myoclonic seizures (HP:0002123)1.95833349
126Abnormality of saccadic eye movements (HP:0000570)1.95705632
127Intellectual disability, moderate (HP:0002342)1.94583019
128Pancreatic fibrosis (HP:0100732)1.94251307
129Blue irides (HP:0000635)1.94186375
130Rigidity (HP:0002063)1.93552339
131Cerebral hypomyelination (HP:0006808)1.93074499
132Ventricular fibrillation (HP:0001663)1.92743429
133Obsessive-compulsive behavior (HP:0000722)1.92502391
134Retinal dysplasia (HP:0007973)1.92141502
135Abnormal respiratory epithelium morphology (HP:0012253)1.91578476
136Abnormal respiratory motile cilium morphology (HP:0005938)1.91578476
137Impaired vibratory sensation (HP:0002495)1.90951601
138Insomnia (HP:0100785)1.89885842
139Hypsarrhythmia (HP:0002521)1.89304854
140Gait ataxia (HP:0002066)1.89286908
141Gait imbalance (HP:0002141)1.89214094
142Segmental peripheral demyelination/remyelination (HP:0003481)1.87893151
143Neoplasm of the peripheral nervous system (HP:0100007)1.87741969
144Autoimmune hemolytic anemia (HP:0001890)1.87733870
145Morphological abnormality of the pyramidal tract (HP:0002062)1.87065494
146Aplasia involving bones of the extremities (HP:0009825)1.85500324
147Aplasia involving bones of the upper limbs (HP:0009823)1.85500324
148Aplasia of the phalanges of the hand (HP:0009802)1.85500324
149Midline defect of the nose (HP:0004122)1.85198048
150Reticulocytopenia (HP:0001896)1.84509790
151Agitation (HP:0000713)1.84388993
152Sensory axonal neuropathy (HP:0003390)1.83655428
153Stereotypic behavior (HP:0000733)1.83181129
154Abnormality of the 4th metacarpal (HP:0010012)1.82645325
155Cutaneous finger syndactyly (HP:0010554)1.81498486
156Abnormality of ocular smooth pursuit (HP:0000617)1.79298568
157Inability to walk (HP:0002540)1.78854188
158Aplasia/Hypoplasia of the uvula (HP:0010293)1.78842665
159Slow saccadic eye movements (HP:0000514)1.78068504
160Optic nerve coloboma (HP:0000588)1.76497543
161Protruding tongue (HP:0010808)1.76202397
162Cystic liver disease (HP:0006706)1.73546972
163Tracheomalacia (HP:0002779)1.72629520
164Basal cell carcinoma (HP:0002671)1.64529290
165Highly arched eyebrow (HP:0002553)1.62907089
166Trigonocephaly (HP:0000243)1.62703140
167Round face (HP:0000311)1.58792991
168Abnormality of the sella turcica (HP:0002679)1.58211275
169Tubulointerstitial nephritis (HP:0001970)1.56119313
170Partial agenesis of the corpus callosum (HP:0001338)1.56062279
171Congenital primary aphakia (HP:0007707)1.55420288
172Cutaneous syndactyly (HP:0012725)1.54276966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.34804820
2NLK3.69812489
3NTRK33.68721833
4MAP3K93.53052196
5MARK13.25256645
6PBK3.12231892
7EPHA42.98246620
8MAP3K42.63623034
9PAK62.59199763
10MINK12.50469101
11CAMK1D2.49403581
12NTRK12.38696306
13KSR22.10079636
14CASK2.07054773
15DAPK22.06312585
16MAP2K72.03663860
17CDK192.02631341
18NTRK21.98463825
19OXSR11.90869708
20STK391.87266093
21PRKD31.82017042
22TNIK1.76002475
23BRD41.68984931
24KIT1.67383206
25NEK21.61035286
26CDK51.59158085
27PRPF4B1.58499948
28PLK41.56410288
29UHMK11.53035935
30PHKG11.52650174
31PHKG21.52650174
32CAMKK11.50307025
33TRIM281.44916115
34MAP2K41.44316942
35MAP3K101.36271407
36TAF11.35485712
37MAPK131.35356167
38GRK51.35339289
39CAMK41.33873163
40PNCK1.32237321
41MAP3K121.30313876
42CCNB11.28891208
43SGK4941.28474181
44SGK2231.28474181
45MAP3K21.25866011
46ARAF1.23112736
47PLK21.22710665
48TYRO31.21351539
49BMPR1B1.21115560
50TAOK31.20388816
51LIMK11.16909911
52WNK11.11808685
53PKN11.11359227
54KSR11.10554889
55CDK121.09094986
56DYRK21.08191252
57CDK141.08126163
58ZAK1.07827565
59PRKCG1.05015684
60RIPK41.04737147
61CSNK1G21.04689997
62CDK151.03162059
63CDK181.02918771
64CAMK2B1.02283321
65CAMK2A0.99657551
66DYRK30.97478963
67YES10.97355280
68PRKCH0.96445348
69PASK0.94894033
70PAK30.94511618
71RET0.94443673
72CAMKK20.94034366
73FES0.92223324
74MAP3K130.91381355
75STK380.90458074
76TLK10.90107175
77CDK11A0.89677140
78LMTK20.89035522
79FGFR20.88586033
80ADRBK20.88583947
81LATS20.87252731
82PINK10.86314324
83MARK20.85385557
84STK110.84482534
85VRK10.82714719
86ROCK20.82000284
87MAPKAPK50.80946565
88BCR0.80116153
89CAMK2D0.78338093
90WNK40.76352774
91NEK60.75488805
92EPHA30.74826179
93DAPK10.74785305
94ACVR1B0.74162104
95MAP4K10.73347717
96CSNK1G30.72050548
97CAMK2G0.71651070
98CAMK10.71360233
99SIK20.70449010
100PTK2B0.69775334
101ALK0.65541180
102PDPK10.64982235
103CDC70.64829911
104CSNK1A1L0.63274548
105DYRK1A0.62122336
106TAOK10.62106463
107SYK0.61737985
108ICK0.60702605
109PRKCE0.60239027
110PDK10.57867889
111SGK10.57002169
112CHEK20.56778708
113FYN0.56353749
114TNK20.56153556
115SGK20.54841062
116MAP3K10.54466059
117CAMK1G0.53981977
118WNK30.53608556
119SGK30.52099153
120TGFBR10.50471213
121DDR20.49734078
122FGR0.49249499
123CDC42BPA0.48816303
124CDK30.47298743
125PRKCZ0.46956879
126MAPK100.45129547
127RPS6KA30.44944288
128TYK20.44766972
129MAP3K70.44473658
130DAPK30.42664540
131RAF10.42018232
132RPS6KA50.41969937
133CSNK1G10.40257616
134ATR0.38169186
135MAPK150.38028109
136PRKG10.36381292
137ROCK10.35862440
138PRKCQ0.34639262
139MAPK40.33205247
140EPHB20.32194581
141CSNK1D0.30059786
142CSF1R0.29341142
143TXK0.27540717
144MAPK70.27483164
145GSK3B0.27184135
146ATM0.26211392
147CDK40.25499269
148NEK90.24349484
149CSNK1A10.22245991
150MKNK20.21985211
151PRKDC0.21145536
152CDK10.21102054
153RPS6KA60.20652761
154BTK0.19940887

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.42572913
2Nicotine addiction_Homo sapiens_hsa050333.30526216
3Systemic lupus erythematosus_Homo sapiens_hsa053223.29889393
4GABAergic synapse_Homo sapiens_hsa047272.78075349
5Olfactory transduction_Homo sapiens_hsa047402.58452742
6Basal cell carcinoma_Homo sapiens_hsa052172.53583086
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51533437
8Circadian entrainment_Homo sapiens_hsa047132.49164387
9Glutamatergic synapse_Homo sapiens_hsa047242.48899085
10Morphine addiction_Homo sapiens_hsa050322.44411658
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26470069
12Long-term potentiation_Homo sapiens_hsa047202.17352816
13Amphetamine addiction_Homo sapiens_hsa050312.04933152
14Salivary secretion_Homo sapiens_hsa049702.04495935
15Dopaminergic synapse_Homo sapiens_hsa047282.01887506
16Insulin secretion_Homo sapiens_hsa049111.87480572
17Colorectal cancer_Homo sapiens_hsa052101.83702471
18Cholinergic synapse_Homo sapiens_hsa047251.83234076
19Gastric acid secretion_Homo sapiens_hsa049711.82522235
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71577313
21Long-term depression_Homo sapiens_hsa047301.68546537
22Taste transduction_Homo sapiens_hsa047421.68213518
23Serotonergic synapse_Homo sapiens_hsa047261.67963369
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66184156
25Cocaine addiction_Homo sapiens_hsa050301.61508810
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60362510
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58726140
28Collecting duct acid secretion_Homo sapiens_hsa049661.58430762
29Fanconi anemia pathway_Homo sapiens_hsa034601.56963621
30Renin secretion_Homo sapiens_hsa049241.49564541
31Axon guidance_Homo sapiens_hsa043601.46025167
32Oxytocin signaling pathway_Homo sapiens_hsa049211.43525083
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40979084
34Calcium signaling pathway_Homo sapiens_hsa040201.36896306
35Nitrogen metabolism_Homo sapiens_hsa009101.35399016
36Gap junction_Homo sapiens_hsa045401.35146060
37Viral carcinogenesis_Homo sapiens_hsa052031.30104292
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30023678
39One carbon pool by folate_Homo sapiens_hsa006701.28745097
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28337863
41GnRH signaling pathway_Homo sapiens_hsa049121.27795986
42Huntingtons disease_Homo sapiens_hsa050161.20950841
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16979345
44cAMP signaling pathway_Homo sapiens_hsa040241.16698953
45Oxidative phosphorylation_Homo sapiens_hsa001901.12636707
46Vibrio cholerae infection_Homo sapiens_hsa051101.08826731
47Type II diabetes mellitus_Homo sapiens_hsa049301.08453299
48Parkinsons disease_Homo sapiens_hsa050121.07107445
49ErbB signaling pathway_Homo sapiens_hsa040121.06800933
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04337599
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04006195
52Estrogen signaling pathway_Homo sapiens_hsa049151.03300340
53Cardiac muscle contraction_Homo sapiens_hsa042601.02981168
54mRNA surveillance pathway_Homo sapiens_hsa030151.01053432
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98208431
56Dorso-ventral axis formation_Homo sapiens_hsa043200.97154368
57Glioma_Homo sapiens_hsa052140.96601120
58RNA polymerase_Homo sapiens_hsa030200.95976278
59Circadian rhythm_Homo sapiens_hsa047100.95248063
60Melanogenesis_Homo sapiens_hsa049160.95160954
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.93991952
62Mismatch repair_Homo sapiens_hsa034300.92938942
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.90651940
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90504594
65Phototransduction_Homo sapiens_hsa047440.90177752
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89361407
67Primary immunodeficiency_Homo sapiens_hsa053400.87933104
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87910905
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85212032
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84160454
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81819328
72Pancreatic secretion_Homo sapiens_hsa049720.81785797
73RNA degradation_Homo sapiens_hsa030180.79638183
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79101799
75B cell receptor signaling pathway_Homo sapiens_hsa046620.78729862
76Acute myeloid leukemia_Homo sapiens_hsa052210.75220064
77Prolactin signaling pathway_Homo sapiens_hsa049170.75146006
78Cell cycle_Homo sapiens_hsa041100.74871095
79Dilated cardiomyopathy_Homo sapiens_hsa054140.73263945
80Endocytosis_Homo sapiens_hsa041440.72284909
81Thyroid hormone synthesis_Homo sapiens_hsa049180.72020274
82Basal transcription factors_Homo sapiens_hsa030220.70985457
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70487330
84MAPK signaling pathway_Homo sapiens_hsa040100.70299794
85T cell receptor signaling pathway_Homo sapiens_hsa046600.69605818
86Oocyte meiosis_Homo sapiens_hsa041140.68438081
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.68267891
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68123461
89MicroRNAs in cancer_Homo sapiens_hsa052060.67094257
90Ras signaling pathway_Homo sapiens_hsa040140.67017393
91Choline metabolism in cancer_Homo sapiens_hsa052310.66682880
92Prostate cancer_Homo sapiens_hsa052150.66635967
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.66554886
94Thyroid cancer_Homo sapiens_hsa052160.66369032
95Renal cell carcinoma_Homo sapiens_hsa052110.62955865
96Selenocompound metabolism_Homo sapiens_hsa004500.62579560
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59990577
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59694197
99Spliceosome_Homo sapiens_hsa030400.59500992
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58925726
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58526822
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57560562
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56394122
104Ribosome_Homo sapiens_hsa030100.56225188
105Bile secretion_Homo sapiens_hsa049760.52419594
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.52338112
107Rap1 signaling pathway_Homo sapiens_hsa040150.51785859
108Alcoholism_Homo sapiens_hsa050340.50607165
109Ether lipid metabolism_Homo sapiens_hsa005650.49306662
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49154145
111Epstein-Barr virus infection_Homo sapiens_hsa051690.49095137
112VEGF signaling pathway_Homo sapiens_hsa043700.48038605
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47567719
114FoxO signaling pathway_Homo sapiens_hsa040680.46545122
115Ovarian steroidogenesis_Homo sapiens_hsa049130.45275299
116Inositol phosphate metabolism_Homo sapiens_hsa005620.44758717
117Chronic myeloid leukemia_Homo sapiens_hsa052200.43073321
118Prion diseases_Homo sapiens_hsa050200.42901800
119Hippo signaling pathway_Homo sapiens_hsa043900.42757558
120Purine metabolism_Homo sapiens_hsa002300.42548014
121Hepatitis B_Homo sapiens_hsa051610.41427519
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41109183
123Butanoate metabolism_Homo sapiens_hsa006500.40728578
124Homologous recombination_Homo sapiens_hsa034400.39730495
125Alzheimers disease_Homo sapiens_hsa050100.39393796
126Non-homologous end-joining_Homo sapiens_hsa034500.39323784
127Tight junction_Homo sapiens_hsa045300.38424309
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38413322
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38302522
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37652090
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37572266
132Wnt signaling pathway_Homo sapiens_hsa043100.36533389
133Endometrial cancer_Homo sapiens_hsa052130.35969136
134Chemokine signaling pathway_Homo sapiens_hsa040620.33579926
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33550444
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.33389591
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32316278
138Hedgehog signaling pathway_Homo sapiens_hsa043400.30799335
139Type I diabetes mellitus_Homo sapiens_hsa049400.30518559
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30070250
141Rheumatoid arthritis_Homo sapiens_hsa053230.29580685
142Insulin signaling pathway_Homo sapiens_hsa049100.28554026
143Glucagon signaling pathway_Homo sapiens_hsa049220.27553490

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